spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1005": 0.06703783571720123, "1011": 0.12470348179340363, "1017": 0.3005385100841522, "1018": 0.2749055027961731, "1019": 0.401551216840744, "1052": 0.25845035910606384, "1060": 0.791648268699646, "1997": 0.016465263441205025, "1998": 0.1946154683828354, "2005": 0.13925230503082275, "2007": 0.1212492436170578, "2008":... | 41403996 | DNA double strand breaks (DSBs) can be rejoined directly by the nonhomologous end-joining (NHEJ) pathway of repair. Nucleases and polymerases are required to promote accurate NHEJ when the terminal bases of the DSB are damaged. The same enzymes also participate in imprecise rejoining and joining of incompatible ends, i... | DNA joint dependence of pol X family polymerase action in nonhomologous end joining. |
{"1037": 0.016465263441205025, "1998": 0.09228714555501938, "2012": 0.2160874605178833, "2035": 0.23556606471538544, "2054": 0.5255602598190308, "2055": 0.0009760859538801014, "2057": 0.10203468054533005, "2064": 0.24631060659885406, "2079": 0.15442965924739838, "2087": 0.0029254043474793434, "2088": 0.2081885337829589... | 41493639 | Burns are one of the most devastating conditions encountered in medicine. The injury represents an assault on all aspects of the patient, from the physical to the psychological. It affects all ages, from babies to elderly people, and is a problem in both the developed and developing world. All of us have experienced th... | ABC of burns. Introduction. |
{"1017": 0.4337083101272583, "1019": 0.009718249551951885, "1041": 0.32553088665008545, "1043": 0.8989537954330444, "1996": 0.02792670577764511, "1999": 0.0009760859538801014, "2008": 0.018384648486971855, "2011": 0.15777134895324707, "2013": 0.1401015669107437, "2025": 0.24171993136405945, "2029": 0.3339579105377197, ... | 41496215 | Astrocyte differentiation, which occurs late in brain development, is largely dependent on the activation of a transcription factor, STAT3. We show that astrocytes, as judged by glial fibrillary acidic protein (GFAP) expression, never emerge from neuroepithelial cells on embryonic day (E) 11.5 even when STAT3 is activa... | DNA methylation is a critical cell-intrinsic determinant of astrocyte differentiation in the fetal brain. |
{"1011": 0.026976587250828743, "1039": 0.4145384132862091, "1040": 0.3622259199619293, "1052": 0.21293537318706512, "1998": 0.13925230503082275, "2004": 0.030771657824516296, "2005": 0.015504186972975731, "2012": 0.21530038118362427, "2029": 0.08064348995685577, "2033": 0.45251765847206116, "2048": 0.20977331697940826,... | 41548287 | Pancreatic ductal adenocarcinoma (PDAC) and other carcinomas are hierarchically organized, with cancer stem cells (CSC) residing at the top of the hierarchy, where they drive tumor progression, metastasis, and chemoresistance. As CSC and non-CSC share an identical genetic background, we hypothesize that differences in ... | DNMT1 Inhibition Reprograms Pancreatic Cancer Stem Cells via Upregulation of the miR-17-92 Cluster. |
{"1015": 0.2954642176628113, "1039": 0.05046287178993225, "1042": 0.2160874605178833, "1043": 0.29981520771980286, "1050": 0.1510767638683319, "2003": 0.25995752215385437, "2011": 0.04487626627087593, "2013": 0.2786078155040741, "2015": 0.2852376699447632, "2028": 0.02792670577764511, "2053": 0.013579257763922215, "207... | 41599676 | Congenital nephrotic syndrome, Finnish type (CNF or NPHS1), is an autosomal recessive disease characterized by massive proteinuria and development of nephrotic syndrome shortly after birth. The disease is most common in Finland, but many patients have been identified in other populations. The disease is caused by mutat... | Mutation spectrum in the nephrin gene (NPHS1) in congenital nephrotic syndrome. |
{"1011": 0.39762192964553833, "1055": 0.6389714479446411, "1999": 0.3615458607673645, "2002": 0.8550800085067749, "2005": 0.14095009863376617, "2006": 0.12642613053321838, "2008": 0.0354953333735466, "2029": 0.2659635543823242, "2047": 0.0797421783208847, "2048": 0.3106105625629425, "2050": 1.109619140625, "2072": 0.22... | 41620295 | We identify the helicase-SANT–associated (HSA) domain as the primary binding platform for nuclear actin-related proteins (ARPs) and actin. Individual HSA domains from chromatin remodelers (RSC, yeast SWI-SNF, human SWI-SNF, SWR1 and INO80) or modifiers (NuA4) reconstitute their respective ARP–ARP or ARP–actin modules. ... | The HSA domain binds nuclear actin-related proteins to regulate chromatin-remodeling ATPases |
{"1016": 0.006812678650021553, "1049": 0.38041436672210693, "1054": 0.5278670787811279, "1055": 0.22704219818115234, "1056": 0.0770333781838417, "1997": 0.1734936386346817, "2003": 0.013579257763922215, "2011": 0.14433705806732178, "2015": 0.42799583077430725, "2026": 0.17020416259765625, "2029": 0.129004567861557, "20... | 41644178 | Rett syndrome is caused by loss-of-function mutations in the gene encoding the methyl DNA-binding factor MeCP2. As brain mass and neuronal complexity tend to be diminished in Rett patients, we tested whether MeCP2 directly influences the morphological complexity of developing neurons. Our results show that cultured mou... | Increased dendritic complexity and axonal length in cultured mouse cortical neurons overexpressing methyl-CpG-binding protein MeCP2 |
{"1017": 0.1602703034877777, "1042": 1.0587663650512695, "1052": 0.043007105588912964, "2025": 0.10291612148284912, "2029": 0.16442140936851501, "2044": 0.5324648022651672, "2064": 0.10379679501056671, "2084": 0.2659635543823242, "2093": 0.16110190749168396, "2172": 0.11168810725212097, "2184": 0.06977381557226181, "22... | 41646286 | Effects of folate deficiency on the rate of apoptosis in human cytotrophoblastic cells has been investigated. Apoptosis was determined in cytotrophoblastic cells after culture in 1. control medium, 2. folate-free medium and 3. folate-free medium plus 10% fetal calf serum. Apoptosis rates in cells cultured in mediums 2 ... | Folate affects apoptosis in human trophoblastic cells. |
{"1011": 0.04860413447022438, "1014": 0.1751343309879303, "1041": 0.8633513450622559, "1047": 1.022197961807251, "1052": 0.5668440461158752, "1999": 0.10467668622732162, "2005": 0.0019512200960889459, "2011": 0.06703783571720123, "2029": 0.05139094591140747, "2099": 0.7791815400123596, "2116": 0.21687394380569458, "212... | 41650417 | PURPOSE To evaluate the effect of KRAS and epidermal growth factor receptor (EGFR) genotype on the response to erlotinib treatment in the BR.21, placebo-controlled trial. PATIENTS AND METHODS We analyzed 206 tumors for KRAS mutation, 204 tumors for EGFR mutation, and 159 tumors for EGFR gene copy by fluorescent in situ... | Role of KRAS and EGFR as biomarkers of response to erlotinib in National Cancer Institute of Canada Clinical Trials Group Study BR.21. |
{"1040": 0.5723689198493958, "1048": 0.21214580535888672, "1049": 0.06154331564903259, "1998": 0.0038986403960734606, "2007": 0.10026945173740387, "2035": 0.07431721687316895, "2090": 0.026025565341114998, "2092": 0.014542185701429844, "2124": 0.025073638185858727, "2139": 0.2711893916130066, "2174": 0.1134333088994026... | 41707539 | It is now well established that depression is associated with immune dysregulation. It is not, however, known whether this immune dysregulation plays a role in the pathophysiology of major depression or whether it increases the susceptibility of the depressed patient to immune-related disorders. This article presents a... | Immune dysregulation in major depression: a critical review of existing evidence. |
{"1013": 0.07250232994556427, "1016": 0.5197699069976807, "1041": 0.791648268699646, "1048": 0.18004031479358673, "1052": 0.5979346632957458, "1996": 0.040196798741817474, "2008": 0.0797421783208847, "2011": 0.4067663550376892, "2029": 0.23556606471538544, "2039": 0.052318159490823746, "2048": 0.2763880789279938, "2076... | 41710132 | The tumor suppressor PML (promyelocytic leukemia protein) regulates cellular senescence and terminal differentiation, two processes that implicate a permanent exit from the cell cycle. Here, we show that the mechanism by which PML induces a permanent cell cycle exit and activates p53 and senescence involves a recruitme... | Regulation of E2Fs and senescence by PML nuclear bodies. |
{"1040": 0.12556517124176025, "1045": 0.11691460013389587, "1996": 0.02316705882549286, "2001": 0.14518201351165771, "2003": 0.2607102394104004, "2028": 0.06886265426874161, "2034": 0.20660123229026794, "2035": 0.29328158497810364, "2042": 0.0797421783208847, "2054": 0.05139094591140747, "2060": 0.014542185701429844, "... | 41735503 | A set of related medical disorders that lack a proper classification system and diagnostic criteria is like a society without laws. The result is incoherence at best, chaos at worst. For this reason, the International Classification of Headache Disorders (ICHD) is arguably the single most important breakthrough in head... | The International Classification of Headache Disorders. |
{"1998": 0.08603433519601822, "2000": 0.025073638185858727, "2001": 0.35060185194015503, "2003": 0.19862671196460724, "2004": 0.16607704758644104, "2005": 0.04207121208310127, "2020": 0.06612417846918106, "2025": 0.03831886500120163, "2039": 0.09761575609445572, "2043": 0.2231435477733612, "2045": 0.25467249751091003, ... | 41774099 | We propose a Medicare Demonstration Project to develop a standard acquisition charge for kidney paired donation. A new payment strategy is required because Medicare and commercial insurance companies may not directly pay living donor costs intended to lead to transplantation of a beneficiary of a different insurance pr... | Call to Develop a Standard Acquisition Charge Model for Kidney Paired Donation |
{"1005": 0.040196798741817474, "1011": 0.41065993905067444, "1051": 0.43812891840934753, "1997": 0.004870930220931768, "1999": 0.018384648486971855, "2003": 0.3526630103588104, "2005": 0.13670019805431366, "2008": 0.06703783571720123, "2011": 0.4330752193927765, "2029": 0.27044451236724854, "2072": 1.0868242979049683, ... | 41781905 | CaMKII is activated by oxidation of methionine residues residing in the regulatory domain. Oxidized CaMKII (ox-CaMKII) is now thought to participate in cardiovascular and pulmonary diseases and cancer. This invited review summarizes current evidence for the role of ox-CaMKII in disease, considers critical knowledge gap... | Oxidant stress promotes disease by activating CaMKII. |
{"1005": 0.0174254160374403, "1055": 0.35677260160446167, "2003": 0.11517547070980072, "2029": 0.013579257763922215, "2038": 0.08244366943836212, "2054": 0.5051454305648804, "2083": 0.5540198087692261, "2087": 0.3757305145263672, "2094": 0.2749055027961731, "2104": 0.5220900774002075, "2106": 0.06520967930555344, "2109... | 41782935 | Alzheimer's disease (AD), the most common form of dementia in western societies, is a pathologically and clinically heterogeneous disease with a strong genetic component. The recent advances in high-throughput genome technologies allowing for the rapid analysis of millions of polymorphisms in thousands of subjects has ... | Genetic diagnosis and prognosis of Alzheimer's disease: challenges and opportunities. |
{"1011": 0.3019835948944092, "1014": 0.27786844968795776, "1019": 0.8022117614746094, "1026": 0.2667117714881897, "1038": 0.18492233753204346, "1044": 0.07159364968538284, "1052": 0.1751343309879303, "1054": 0.18329764902591705, "1058": 0.35950297117233276, "1059": 0.8796916007995605, "1081": 0.804835319519043, "2004":... | 41790911 | Experimental studies have suggested that Wingless-related integration site 5A (WNT5A) is a proinflammatory secreted protein that is associated with metabolic dysfunction in obesity. Impaired angiogenesis in fat depots has been implicated in the development of adipose tissue capillary rarefaction, hypoxia, inflammation,... | WNT5A regulates adipose tissue angiogenesis via antiangiogenic VEGF-A165b in obese humans. |
{"1013": 0.015504186972975731, "1015": 0.17922431230545044, "1051": 0.16276304423809052, "1055": 0.009718249551951885, "1997": 0.016465263441205025, "2000": 0.013579257763922215, "2005": 0.3416208028793335, "2011": 0.23710809648036957, "2012": 0.0770333781838417, "2015": 0.619189441204071, "2029": 0.18816383183002472, ... | 41811327 | Homothallic yeast cells undergo a specific pattern of mating-type switching initiated by an endonuclease encoded by the HO gene. HO transcription is affected by cell type (a, alpha, and a/alpha), by cell age (mother or daughter), and by the cell cycle. This paper investigates the sequences involved in HO transcription ... | At least 1400 base pairs of 5'-flanking DNA is required for the correct expression of the HO gene in yeast. |
{"1011": 0.08692999184131622, "1039": 0.10906458646059036, "1996": 0.011650617234408855, "2005": 0.20739519596099854, "2015": 0.30917787551879883, "2044": 0.6139179468154907, "2045": 0.21765978634357452, "2054": 0.0009760859538801014, "2064": 0.1212492436170578, "2067": 0.11343330889940262, "2078": 0.0913962796330452, ... | 41822527 | Trauma to the central nervous system (CNS) triggers intraparenchymal inflammation and activation of systemic immunity with the capacity to exacerbate neuropathology and stimulate mechanisms of tissue repair. Despite our incomplete understanding of the mechanisms that control these divergent functions, immune-based ther... | Inflammation and its role in neuroprotection, axonal regeneration and functional recovery after spinal cord injury. |
{"1011": 0.2184450328350067, "1015": 0.6527929902076721, "1018": 0.2145126610994339, "1019": 0.4356052577495575, "1020": 0.4093637466430664, "1040": 0.037378571927547455, "1041": 0.46608972549438477, "1044": 0.3864043951034546, "1045": 0.8845420479774475, "1050": 0.30989447236061096, "1055": 0.2749055027961731, "1058":... | 41852733 | Ehlers-Danlos syndrome (EDS) type I (the classical variety) is a dominantly inherited, genetically heterogeneous connective-tissue disorder. Mutations in the COL5A1 and COL5A2 genes, which encode type V collagen, have been identified in several individuals. Most mutations affect either the triple-helical domain of the ... | Order of intron removal influences multiple splice outcomes, including a two-exon skip, in a COL5A1 acceptor-site mutation that results in abnormal pro-alpha1(V) N-propeptides and Ehlers-Danlos syndrome type I. |
{"1009": 0.7969439625740051, "1011": 0.22937409579753876, "1017": 0.06246116757392883, "1018": 0.3070250153541565, "1039": 0.07250232994556427, "1047": 0.8981585502624512, "1056": 0.9485763907432556, "1999": 0.04767346754670143, "2007": 0.1693800985813141, "2011": 0.35334911942481995, "2012": 0.34370049834251404, "2015... | 41877386 | CD4(+)CD25(+) regulatory T cells (T regs) play a major role in the maintenance of self-tolerance and immune suppression, although the mechanisms controlling T reg development and suppressor function remain incompletely understood. Herein, we provide evidence that Kruppel-like factor 10 (KLF10/TIEG1) constitutes an impo... | Kruppel-like factor KLF10 targets transforming growth factor-beta1 to regulate CD4(+)CD25(-) T cells and T regulatory cells. |
{"1021": 0.28082266449928284, "1052": 0.8567397594451904, "1997": 0.45870962738990784, "1999": 0.0797421783208847, "2012": 0.22704219818115234, "2013": 0.07159364968538284, "2029": 0.19541899859905243, "2043": 0.058784693479537964, "2052": 0.22937409579753876, "2064": 0.026025565341114998, "2071": 0.07612881064414978, ... | 41900731 | The pH dependence of the quaternary structure of pyruvate decarboxylase from yeast was studied in the range 6.2 less than pH less than 8.4. There is an equilibrium with a midpoint around pH 7.5 between tetramers and dimers, and the catalytic activity of the enzyme depends on the volume fraction of tetramer. This equili... | Synchrotron radiation solution X-ray scattering study of the pH dependence of the quaternary structure of yeast pyruvate decarboxylase. |
{"1011": 0.38374659419059753, "1022": 0.38574060797691345, "1044": 0.052318159490823746, "1999": 0.012615402229130268, "2011": 0.058784693479537964, "2019": 0.6639154553413391, "2029": 0.3012613356113434, "2051": 0.10467668622732162, "2064": 0.4938860833644867, "2066": 0.49864232540130615, "2080": 0.09938567131757736, ... | 41911192 | The effect that chronic unpredictable stress had on the anxiety-like response elicited by the cannabinoid receptor agonist HU-210 [3-(1,1-dimethylheptyl)-(-)-11-hydroxy-delta 8-tetrahydrocannabinol] in the elevated plus maze was investigated here. Male Long-Evans rats were either unstressed or were subjected to a 21-da... | Enhancement of anxiety-like responsiveness to the cannabinoid CB(1) receptor agonist HU-210 following chronic stress. |
{"1015": 0.25845035910606384, "1043": 0.5387523174285889, "1050": 0.7764897346496582, "1155": 0.5069117546081543, "1164": 0.5209306478500366, "1997": 0.021256839856505394, "1998": 0.13755162060260773, "2002": 0.7809720039367676, "2005": 0.12728634476661682, "2007": 0.0606246218085289, "2029": 0.16524957120418549, "2064... | 41913714 | Digitoxin and structurally related cardiac glycoside drugs potently block activation of the TNF-α/NF-κB signaling pathway. We have hypothesized that the mechanism might be discovered by searching systematically for selective inhibitory action through the entire pathway. We report that the common action of these drugs i... | Cardiac glycosides inhibit TNF-α/NF-κB signaling by blocking recruitment of TNF receptor-associated death domain to the TNF receptor |
{"1040": 0.1358480453491211, "1062": 0.9348671436309814, "1999": 0.0029254043474793434, "2015": 0.6471850275993347, "2044": 0.1401015669107437, "2076": 0.16607704758644104, "2092": 0.12728634476661682, "2116": 0.09850110858678818, "2146": 0.11604541540145874, "2154": 0.23247487843036652, "2172": 0.5712664127349854, "21... | 41915616 | The effects of a zinc supplement on maternal zinc status and milk zinc concentrations through > or = 7 mo of lactation were examined. Seventy-one lactating women received either a daily 15-mg zinc supplement (ZS, n = 40) or placebo (NZS, n = 31) started by 2 wk postpartum in a double-blind, randomized design. Overall m... | Zinc supplementation during lactation: effects on maternal status and milk zinc concentrations. |
{"1003": 0.29400965571403503, "1014": 0.11430477350950241, "1040": 0.8682814836502075, "1999": 0.012615402229130268, "2003": 0.0354953333735466, "2004": 0.22704219818115234, "2005": 0.2607102394104004, "2011": 0.0770333781838417, "2029": 0.17840765416622162, "2046": 0.3601844012737274, "2058": 0.08064348995685577, "206... | 41925568 | Dimethyl sulfoxide (DMSO) is becoming increasingly popular as a vehicle in studies employing central injections. The aim of the present study was to determine whether the vehicle required for solubilization of substances for central injection [75% DMSO and 25% artificial CSF (aCSF)] would alter the well-characterized s... | DMSO as a vehicle for central injections: tests with feeding elicited by norepinephrine injected into the paraventricular nucleus. |
{"1009": 0.7978238463401794, "1011": 0.28450319170951843, "1020": 0.02887592278420925, "1039": 0.38905516266822815, "1997": 0.013579257763922215, "1998": 0.1970241367816925, "2002": 0.5893046259880066, "2003": 0.24631060659885406, "2005": 0.11343330889940262, "2008": 0.09050461649894714, "2011": 0.18167030811309814, "2... | 41928290 | TIP48 and TIP49 are two related and highly conserved eukaryotic AAA(+) proteins with an essential biological function and a critical role in major pathways that are closely linked to cancer. They are found together as components of several highly conserved chromatin-modifying complexes. Both proteins show sequence homo... | Dodecameric structure and ATPase activity of the human TIP48/TIP49 complex. |
{"1014": 0.23556606471538544, "1018": 0.01934296265244484, "1023": 0.06795065850019455, "1028": 0.17431432008743286, "1053": 0.006812678650021553, "2004": 0.2317005842924118, "2006": 0.022212404757738113, "2007": 0.3027053773403168, "2012": 0.3683255612850189, "2028": 0.43812891840934753, "2043": 0.004870930220931768, ... | 41976370 | OBJECTIVE Our aim was to provide a quantitative assessment of the exposure-response relationships between work-related physical and psychosocial factors and the occurrence of specific shoulder disorders in occupational populations. METHODS A systematic review of the literature was conducted on the associations between ... | Associations between work-related factors and specific disorders of the shoulder--a systematic review of the literature. |
{"1011": 0.32270604372024536, "1056": 0.8298473954200745, "1996": 0.40285754203796387, "2003": 0.28155985474586487, "2024": 0.036437395960092545, "2029": 0.03360854089260101, "2054": 0.05046287178993225, "2063": 0.2231435477733612, "2090": 0.5021947622299194, "2099": 0.9348671436309814, "2109": 0.20421554148197174, "21... | 41982985 | The immunological synapse is a specialized cell-cell junction that is defined by large-scale spatial patterns of receptors and signaling molecules yet remains largely enigmatic in terms of formation and function. We used supported bilayer membranes and nanometer-scale structures fabricated onto the underlying substrate... | Altered TCR signaling from geometrically repatterned immunological synapses. |
{"1011": 0.13071982562541962, "1015": 0.3784096837043762, "1017": 0.08154398202896118, "1044": 0.6296497583389282, "1047": 0.5455666780471802, "1048": 0.3923587501049042, "1996": 0.07341018319129944, "1997": 0.16442140936851501, "1999": 0.2786078155040741, "2005": 0.4450363218784332, "2007": 0.025073638185858727, "2008... | 42009630 | The Set1-containing complex COMPASS, which is the yeast homolog of the human MLL complex, is required for mono-, di-, and trimethylation of lysine 4 of histone H3. We have performed a comparative global proteomic screen to better define the role of COMPASS in histone trimethylation. We report that both Cps60 and Cps40 ... | Molecular regulation of histone H3 trimethylation by COMPASS and the regulation of gene expression. |
{"1011": 0.05139094591140747, "1017": 0.2105647772550583, "1043": 0.4974553883075714, "1060": 0.4831010699272156, "1157": 0.09317722171545029, "1996": 0.021256839856505394, "2004": 0.6332852244377136, "2008": 0.1011524572968483, "2011": 0.42544642090797424, "2012": 0.24171993136405945, "2015": 0.22859740257263184, "202... | 42035464 | Microtubule nucleation is the best known function of centrosomes. Centrosomal microtubule nucleation is mediated primarily by gamma tubulin ring complexes (gamma TuRCs). However, little is known about the molecules that anchor these complexes to centrosomes. In this study, we show that the centrosomal coiled-coil prote... | Mitosis-specific anchoring of gamma tubulin complexes by pericentrin controls spindle organization and mitotic entry. |
{"1006": 0.056018441915512085, "1009": 0.7267557382583618, "1011": 0.08064348995685577, "1015": 0.2659635543823242, "1018": 0.28155985474586487, "1019": 0.05139094591140747, "1020": 0.3339579105377197, "1022": 0.47584590315818787, "1039": 0.1384023278951645, "1045": 0.36358460783958435, "1048": 0.5450005531311035, "105... | 42065070 | Early events during human immunodeficiency virus infections are considered to reflect the capacity of the host to control infection. We have studied early virus and host parameters during the early phase of simian immunodeficiency virus SIVmnd-1 nonpathogenic infection in its natural host, Mandrillus sphinx. Four mandr... | High levels of viral replication contrast with only transient changes in CD4(+) and CD8(+) cell numbers during the early phase of experimental infection with simian immunodeficiency virus SIVmnd-1 in Mandrillus sphinx. |
{"1043": 0.3269403576850891, "1058": 0.757441520690918, "2005": 0.35060185194015503, "2012": 0.016465263441205025, "2029": 0.11951763927936554, "2038": 0.0752234235405922, "2043": 0.0058422754518687725, "2051": 0.12038381397724152, "2076": 0.637939989566803, "2079": 0.05139094591140747, "2104": 0.46486347913742065, "21... | 42080024 | Several growth factors are expressed in distinct temporal and spatial patterns during fracture repair. Of these, vascular endothelial growth factor, VEGF, is of particular interest because of its ability to induce neovascularization (angiogenesis). To determine whether VEGF is required for bone repair, we inhibited VEG... | Vascular endothelial growth factor stimulates bone repair by promoting angiogenesis and bone turnover. |
{"1039": 0.29400965571403503, "1040": 0.058784693479537964, "1998": 0.20580662786960602, "2003": 0.02792670577764511, "2007": 0.2409527748823166, "2051": 0.2184450328350067, "2086": 0.5063233375549316, "2087": 0.18329764902591705, "2095": 0.055094651877880096, "2099": 0.06977381557226181, "2111": 0.42353010177612305, "... | 42095718 | Clinical evidence suggests that chronic daily headache (CDH) occurs in association with psychopathologies: previous studies have focused particularly on migraine. To evaluate this association, we studied, using the DSM-IIIR criteria, a population of 88 patients (18M, 70F) affected by CDH (mean duration 7.4 +/- 8.7 year... | Psychiatric comorbidity in chronic daily headache. |
{"1011": 0.24401791393756866, "1018": 0.6583697199821472, "1051": 0.03925827145576477, "1999": 0.0797421783208847, "2003": 0.11430477350950241, "2005": 0.11865071207284927, "2007": 0.37707099318504333, "2008": 0.043007105588912964, "2011": 0.35745587944984436, "2029": 0.34370049834251404, "2030": 0.10555581003427505, "... | 42106119 | The transcription factor Oct4 is key in embryonic stem cell identity and reprogramming. Insight into its partners should illuminate how the pluripotent state is established and regulated. Here, we identify a considerably expanded set of Oct4-binding proteins in mouse embryonic stem cells. We find that Oct4 associates w... | An Expanded Oct4 Interaction Network: Implications for Stem Cell Biology, Development, and Disease |
{"1003": 0.06977381557226181, "1011": 0.030771657824516296, "1039": 0.32058215141296387, "1044": 0.04487626627087593, "1049": 0.5607312321662903, "1051": 0.8022117614746094, "1052": 0.2247048318386078, "2003": 0.20580662786960602, "2020": 0.015504186972975731, "2025": 0.09584271162748337, "2033": 0.1913948506116867, "2... | 42150015 | CONTEXT Anti-müllerian hormone (AMH) is an ovarian reserve marker that is increasingly applied in clinical practice as a prognostic and diagnostic tool. Despite increased use of AMH in clinical practice, large-scale studies addressing the influence of possible determinants on AMH levels are scarce. OBJECTIVE We aimed t... | Reproductive and lifestyle determinants of anti-Müllerian hormone in a large population-based study. |
{"1003": 0.2501201331615448, "1050": 0.036437395960092545, "1998": 0.4891071021556854, "2001": 0.1677299439907074, "2005": 0.1212492436170578, "2007": 0.12814582884311676, "2020": 0.04674193635582924, "2041": 0.009718249551951885, "2043": 0.06612417846918106, "2044": 0.23015019297599792, "2062": 0.35677260160446167, "2... | 42185082 | Factors associated with primary care utilization and health insurance coverage were examined among 511 women leaving jail in New York City from 1997-2001. One year after release, roughly half of the sample reported primary care utilization (47%) and health insurance coverage (56%). Neither outcome was more likely among... | Primary care and health insurance among women released from New York City jails. |
{"1011": 0.0913962796330452, "1017": 0.0038986403960734606, "1043": 0.13670019805431366, "1047": 0.5393219590187073, "1050": 0.48670899868011475, "1997": 0.030771657824516296, "1999": 0.3949938118457794, "2011": 0.3269403576850891, "2013": 0.22937409579753876, "2020": 0.04860413447022438, "2029": 0.0606246218085289, "2... | 42240424 | Native mammalian prions exist in self-propagating strains that exhibit distinctive clinical, pathological and biochemical characteristics. Prion strain diversity is associated with variations in PrP(Sc) conformation, but it remains unknown precisely which physical properties of the PrP(Sc) molecules are required to enc... | The effects of prion protein proteolysis and disaggregation on the strain properties of hamster scrapie. |
{"1011": 0.3177432417869568, "1015": 0.07884006202220917, "1017": 0.07159364968538284, "1023": 0.020300358533859253, "1043": 0.43053874373435974, "1044": 0.6699305176734924, "1048": 0.7629209756851196, "1997": 0.03925827145576477, "1999": 0.1229778528213501, "2005": 0.036437395960092545, "2008": 0.0009760859538801014, ... | 42267740 | Various proteins have been found to play roles in both the repair of UV damaged DNA and heterochromatin-mediated silencing in the yeast Saccharomyces cerevisiae. In particular, factors that are involved in the methylation of lysine-79 of histone H3 by Dot1p have been implicated in both processes, suggesting a bipartite... | Methylation of histone H3 lysine-79 by Dot1p plays multiple roles in the response to UV damage in Saccharomyces cerevisiae. |
{"1003": 0.10379679501056671, "1997": 0.2749055027961731, "2007": 0.058784693479537964, "2043": 0.21765978634357452, "2062": 0.16690383851528168, "2086": 0.22704219818115234, "2095": 0.1913948506116867, "2096": 0.16442140936851501, "2108": 0.1602703034877777, "2111": 0.6054253578186035, "2116": 0.5551415085792542, "212... | 42278130 | PURPOSE This study examined the prevalence, correlates, and negative consequences of unmet need for personal assistance with activities of daily living (ADLs) among older adults. DESIGN AND METHODS The authors analyzed cross-sectional data from the 1994 National Health Interview Survey's Supplement on Aging. Data were ... | Unmet need for personal assistance with activities of daily living among older adults. |
{"1011": 0.053244512528181076, "1016": 0.7710843086242676, "2000": 0.1619328260421753, "2003": 0.0038986403960734606, "2022": 0.11604541540145874, "2042": 0.13071982562541962, "2043": 0.22001366317272186, "2048": 0.890972912311554, "2051": 0.5827828645706177, "2064": 0.10379679501056671, "2075": 0.08244366943836212, "2... | 42279414 | For more than 60 years, the chemical induction of tumors in mouse skin has been used to study mechanisms of epithelial carcinogenesis and evaluate modifying factors. In the traditional two-stage skin carcinogenesis model, the initiation phase is accomplished by the application of a sub-carcinogenic dose of a carcinogen... | Multi-stage chemical carcinogenesis in mouse skin: Fundamentals and applications |
{"1023": 0.5871354341506958, "2001": 0.24248650670051575, "2015": 0.2969166338443756, "2018": 0.09050461649894714, "2020": 0.12038381397724152, "2038": 0.0019512200960889459, "2042": 0.3027053773403168, "2043": 0.24248650670051575, "2045": 0.1751343309879303, "2055": 0.08782484382390976, "2073": 0.09761575609445572, "2... | 42291761 | Detailed information on drowning in children is not routinely collected by offices of national statistics. Few studies have been carried out in the United Kingdom, and none has been done on British children abroad. In 1988-9, two of the authors (AMK and JRS) combined information from national statistical offices, polic... | Preventing deaths by drowning in children in the United Kingdom: have we made progress in 10 years? Population based incidence study. |
{"1019": 0.38174858689308167, "1041": 0.75193190574646, "1044": 0.7028654217720032, "1997": 0.1510767638683319, "1998": 0.04113444685935974, "1999": 0.11343330889940262, "2007": 0.04394211992621422, "2029": 0.14686977863311768, "2048": 0.10026945173740387, "2060": 0.3416208028793335, "2075": 0.04394211992621422, "2080"... | 42298280 | We evaluated the levels and distribution of hypoxia in 31 human tumors using fluorescent immunohistochemical detection of binding by the 2-nitroimidazole, EF5. Hypoxia was found to be a heterogeneous property of human tumors. Necrosis was usually found adjacent to the highest level of binding in an individual patient's... | Hypoxic heterogeneity in human tumors: EF5 binding, vasculature, necrosis, and proliferation. |
{"1011": 0.33115679025650024, "1015": 0.5712664127349854, "1017": 0.1913948506116867, "1039": 0.3683255612850189, "1043": 0.7925328612327576, "1050": 0.29400965571403503, "1051": 0.2145126610994339, "1062": 0.24325250089168549, "2003": 0.011650617234408855, "2004": 0.22626367211341858, "2005": 0.025073638185858727, "20... | 42314147 | Sp1-like proteins are characterized by three conserved C-terminal zinc finger motifs that bind GC-rich sequences found in promoters of numerous genes essential for mammalian cell homeostasis. These proteins behave as transcriptional activators or repressors. Although significant information has been reported on the mol... | The Sp1-like protein BTEB3 inhibits transcription via the basic transcription element box by interacting with mSin3A and HDAC-1 co-repressors and competing with Sp1. |
{"1014": 0.4349733293056488, "1015": 0.1064341589808464, "1017": 0.21135559678077698, "1018": 0.2659635543823242, "1019": 0.4132472574710846, "1020": 0.28450319170951843, "1055": 0.3106105625629425, "1997": 0.1384023278951645, "2012": 0.20501139760017395, "2020": 0.09317722171545029, "2028": 0.3423145115375519, "2051":... | 42330403 | Numerosity judgments of simultaneous talkers were examined. Listeners were required to report the number of talkers heard when this number varied (1 to 13). Spatial location of talkers (1 or 6 locations), duration of talker voices (0.8 s, 5.0 s, and 15.0 s), and gender arrangement of talkers also were manipulated in fo... | Perceptual limits in a simulated "Cocktail party". |
{"1014": 0.3034266233444214, "1018": 0.5127768516540527, "1044": 0.08692999184131622, "2001": 0.08961215615272522, "2015": 0.9500881433486938, "2020": 0.03831886500120163, "2055": 0.08961215615272522, "2058": 0.08244366943836212, "2086": 0.18654440343379974, "2116": 0.2711893916130066, "2146": 0.28890204429626465, "217... | 42373087 | This paper describes the development and evaluation of a brief, multidimensional, self-administered, social support survey that was developed for patients in the Medical Outcomes Study (MOS), a two-year study of patients with chronic conditions. This survey was designed to be comprehensive in terms of recent thinking a... | The MOS social support survey. |
{"1013": 0.02316705882549286, "1044": 0.23247487843036652, "1048": 0.16690383851528168, "1055": 0.5381823778152466, "2002": 0.24248650670051575, "2003": 0.09317722171545029, "2004": 0.1994270235300064, "2007": 0.1693800985813141, "2019": 0.47036975622177124, "2042": 0.11951763927936554, "2063": 0.23864774405956268, "20... | 42373943 | BACKGROUND Malaria is considered as the main differential diagnosis of acute febrile illness in the tropics, and alteration of various hematological parameters has been observed in patients with malaria. AIM To ascertain if certain hematological parameters increase the probability of malaria in patients with acute febr... | Can hematological parameters discriminate malaria from nonmalarious acute febrile illness in the tropics? |
{"1011": 0.2145126610994339, "1014": 0.0174254160374403, "1015": 0.037378571927547455, "1020": 0.08603433519601822, "1038": 0.5646255612373352, "1045": 0.8091925978660583, "1048": 0.5936289429664612, "1052": 0.020300358533859253, "1053": 0.5318912267684937, "1055": 0.35060185194015503, "1056": 0.5756692886352539, "1997... | 42377686 | Deletions of the long arm of chromosome 14 [del(14q)] are rare but recurrently observed in mature B-cell neoplasms, particularly in chronic lymphocytic leukemia (CLL). To further characterize this aberration, we studied 81 cases with del(14q): 54 of CLL and 27 of small lymphocytic lymphoma (SLL), the largest reported s... | 14q deletions are associated with trisomy 12, NOTCH1 mutations and unmutated IGHV genes in chronic lymphocytic leukemia and small lymphocytic lymphoma. |
{"1014": 0.43812891840934753, "1015": 0.053244512528181076, "1019": 0.0770333781838417, "1021": 0.07068414986133575, "1044": 0.11168810725212097, "1052": 0.565735399723053, "1999": 0.0354953333735466, "2011": 0.06703783571720123, "2012": 0.2026219218969345, "2033": 0.05046287178993225, "2042": 0.15693697333335876, "204... | 42387637 | RATIONALE Exposure to particulate air pollution has been related to increased hospitalization and death, particularly from cardiovascular disease. Lower blood DNA methylation content is found in processes related to cardiovascular outcomes, such as oxidative stress, aging, and atherosclerosis. OBJECTIVES We evaluated w... | Rapid DNA methylation changes after exposure to traffic particles. |
{"1003": 0.14433705806732178, "1014": 0.11256109178066254, "1018": 0.043007105588912964, "1019": 0.07431721687316895, "1020": 0.1930064558982849, "1997": 0.02887592278420925, "1998": 0.17922431230545044, "2000": 0.129004567861557, "2001": 0.055094651877880096, "2012": 0.011650617234408855, "2020": 0.2696990668773651, "... | 42404093 | OBJECTIVES To assess incidence and preventability of adverse drug events (ADEs) and potential ADEs. To analyze preventable events to develop prevention strategies. DESIGN Prospective cohort study. PARTICIPANTS All 4031 adult admissions to a stratified random sample of 11 medical and surgical units in two tertiary care ... | Incidence of adverse drug events and potential adverse drug events. Implications for prevention. ADE Prevention Study Group. |
{"1014": 0.28670501708984375, "1040": 0.06154331564903259, "1997": 0.1930064558982849, "2000": 0.2918238639831543, "2004": 0.129004567861557, "2006": 0.16110190749168396, "2007": 0.15526613593101501, "2011": 0.35334911942481995, "2012": 0.007782140281051397, "2029": 0.2674594223499298, "2043": 0.12642613053321838, "204... | 42421723 | The induced synthesis of galactokinase and the repressing effects of glucose on this synthesis have been investigated in whole yeast cells rendered permeable by treatment with dimethyl sulfoxide. It was found that the induction response of uninduced cells to galactose is clearly dependent on the nature of the carbon so... | Induction of galactokinase in Saccharomyces cerevisiae: kinetics of induction and glucose effects. |
{"1011": 0.009718249551951885, "1014": 0.2659635543823242, "1020": 0.1693800985813141, "1021": 0.24171993136405945, "1038": 0.3339579105377197, "1039": 0.6629094481468201, "1042": 0.8559102416038513, "1052": 0.19862671196460724, "1056": 0.1384023278951645, "2003": 0.08064348995685577, "2005": 0.03831886500120163, "2007... | 42441846 | INTRODUCTION Elevated plasma total homocysteine is a major risk for coronary artery disease (CAD). Methyltetrahydrofolate reductase (MTHFR) is a main regulatory enzyme in homocysteine metabolism; a common C677T mutation in the MTHFR gene results in decreased enzyme activity, and contributes to increased homocysteine le... | Gene--nutrition interactions in coronary artery disease: correlation between the MTHFR C677T polymorphism and folate and homocysteine status in a Korean population. |
{"1009": 0.43875885009765625, "1011": 0.22157983481884003, "1015": 0.21135559678077698, "1038": 0.9115922451019287, "1044": 0.09495500475168228, "2002": 0.2223619967699051, "2011": 0.2659635543823242, "2015": 0.07159364968538284, "2024": 0.22548456490039825, "2029": 0.2018241584300995, "2034": 0.17267228662967682, "203... | 42465769 | Adipocytes are part of hematopoietic microenvironment, even though up to now in humans, their role in hematopoiesis is still questioned. We have previously shown that accumulation of fat cells in femoral bone marrow (BM) coincides with increased expression of neuropilin-1 (NP-1), while it is weakly expressed in hematop... | Human bone marrow adipocytes block granulopoiesis through neuropilin-1-induced granulocyte colony-stimulating factor inhibition. |
{"1006": 0.009718249551951885, "1011": 0.13925230503082275, "1017": 0.12384103983640671, "1040": 0.3743882179260254, "1041": 0.679875910282135, "1044": 0.021256839856505394, "1998": 0.44753631949424744, "2002": 0.8715548515319824, "2004": 0.0058422754518687725, "2005": 0.10906458646059036, "2007": 0.009718249551951885,... | 42484543 | Human embryonic stem (ES) cell lines that have the ability to self-renew and differentiate into specific cell types have been established. The molecular mechanisms for self-renewal and differentiation, however, are poorly understood. We determined the transcriptome profiles for two proprietary human ES cell lines (HES3... | The transcriptome profile of human embryonic stem cells as defined by SAGE. |
{"1011": 0.10555581003427505, "1052": 1.1281205415725708, "1060": 0.6338034868240356, "2005": 0.18329764902591705, "2007": 0.06154331564903259, "2011": 0.3353555500507355, "2029": 0.2247048318386078, "2034": 0.1930064558982849, "2049": 0.05694137513637543, "2071": 0.2223619967699051, "2076": 0.09406650811433792, "2079"... | 42489926 | p53 regulates a key pathway which protects normal tissues from tumor development that may result from diverse forms of stress. In the absence of stress, growth suppressive and proapoptotic activity of p53 is inhibited by MDM2 which binds p53 and negatively regulates its activity and stability. MDM2 antagonists could ac... | Small-molecule antagonists of p53-MDM2 binding: research tools and potential therapeutics. |
{"1006": 0.034552380442619324, "1011": 0.30989447236061096, "1017": 0.28890204429626465, "1039": 0.13157635927200317, "1156": 0.6128603219985962, "1997": 0.06977381557226181, "2001": 0.06703783571720123, "2015": 0.15442965924739838, "2020": 0.12986256182193756, "2025": 0.10026945173740387, "2029": 0.04860413447022438, ... | 42520882 | Expansion of (CTG)•(CAG) repeats, the cause of 14 or more diseases, is presumed to arise through escaped repair of slipped DNAs. We report the fidelity of slipped-DNA repair using human cell extracts and DNAs with slip-outs of (CAG)20 or (CTG)20. Three outcomes occurred: correct repair, escaped repair and error-prone r... | Slipped (CTG)•(CAG) repeats can be correctly repaired, escape repair or undergo error-prone repair |
{"1011": 0.0606246218085289, "1013": 0.18492233753204346, "1015": 0.175953671336174, "1017": 0.41195443272590637, "1041": 0.12642613053321838, "1043": 0.7426811456680298, "1055": 0.8625272512435913, "2008": 0.13670019805431366, "2011": 0.1677299439907074, "2029": 0.3325583338737488, "2043": 0.08603433519601822, "2044":... | 42565477 | The molecular mechanism underlying G1/S checkpoint bypass in mouse embryonic stem cells (ESCs) remains unknown. DNA damage blocks S phase entry by inhibiting the CDK2 kinase through destruction of its activator, the Cdc25A phosphatase. We observed high Cdc25A levels in G1 that persist even after DNA damage in mouse ESC... | High Dub3 expression in mouse ESCs couples the G1/S checkpoint to pluripotency. |
{"1009": 0.29328158497810364, "1011": 0.1905880719423294, "1014": 0.33605360984802246, "1020": 0.255429208278656, "1022": 0.2719337046146393, "1026": 0.46363574266433716, "1038": 0.9621002674102783, "1040": 0.5197699069976807, "1052": 0.6249561905860901, "1054": 0.28450319170951843, "2000": 0.045809537172317505, "2003"... | 42601237 | OBJECTIVE To determine the optimal bone marrow (BM) cell types, and their potential mechanisms of action for neovascularization in chronic ischaemic myocardium. METHODS AND RESULTS The functional effects, angiogenic potential and cytokine expression of direct intramyocardial implantation of autologous BM CD31-positive ... | Paracrine effects of direct intramyocardial implantation of bone marrow derived cells to enhance neovascularization in chronic ischaemic myocardium. |
{"1011": 0.40220460295677185, "1041": 0.14939609169960022, "1054": 0.0606246218085289, "1056": 0.7934166193008423, "1996": 0.07612881064414978, "1998": 0.029824240133166313, "1999": 0.0009760859538801014, "2007": 0.23247487843036652, "2008": 0.05786345899105072, "2011": 0.304147332906723, "2015": 0.28082266449928284, "... | 42662816 | The embryonic stem cell (ESC) transcriptional and epigenetic networks are controlled by a multilayer regulatory circuitry, including core transcription factors (TFs), posttranscriptional modifier microRNAs (miRNAs), and some other regulators. However, the role of large intergenic noncoding RNAs (lincRNAs) in this regul... | Endogenous miRNA sponge lincRNA-RoR regulates Oct4, Nanog, and Sox2 in human embryonic stem cell self-renewal. |
{"1006": 0.014542185701429844, "1007": 0.2184450328350067, "1009": 1.0815403461456299, "1011": 0.16110190749168396, "1017": 0.6911921501159668, "1042": 0.030771657824516296, "1043": 0.6327666640281677, "1045": 0.5662899017333984, "1052": 0.1930064558982849, "1056": 1.1121915578842163, "1996": 0.04953393340110779, "2004... | 42693833 | Foxp3(+) T cells play a critical role for the maintenance of immune tolerance. Here we show that in mice, Foxp3(+) T cells contributed to diversification of gut microbiota, particularly of species belonging to Firmicutes. The control of indigenous bacteria by Foxp3(+) T cells involved regulatory functions both outside ... | Foxp3(+) T cells regulate immunoglobulin a selection and facilitate diversification of bacterial species responsible for immune homeostasis. |
{"1011": 0.31489628553390503, "1014": 0.2089812457561493, "1017": 0.42990362644195557, "1018": 0.6016870141029358, "1019": 0.9333322048187256, "1022": 0.36086538434028625, "1038": 0.57457035779953, "1039": 0.10818854719400406, "1040": 0.1751343309879303, "1043": 0.23092569410800934, "1047": 0.7086513638496399, "1049": ... | 42708716 | We report the cDNA cloning and characterization of a novel human inositol polyphosphate 5-phosphatase (5-phosphatase) that has substrate specificity unlike previously described members of this large gene family. All previously described members hydrolyze water soluble inositol phosphates. This enzyme hydrolyzes only li... | The isolation and characterization of a cDNA encoding phospholipid-specific inositol polyphosphate 5-phosphatase. |
{"1011": 0.07431721687316895, "1016": 0.3325583338737488, "1056": 0.09050461649894714, "2006": 0.24248650670051575, "2007": 0.037378571927547455, "2025": 0.1477125883102417, "2029": 0.0606246218085289, "2039": 0.47463157773017883, "2041": 0.09317722171545029, "2044": 0.0354953333735466, "2053": 0.004870930220931768, "2... | 42731834 | Functional studies on colorectal cancer cells indicated a protective role of the interferon-inducible dsDNA sensor Absent in Melanoma 2 (AIM2) in cancer progression. Given that a high mutation rate and lack of AIM2 expression was previously detected in a subset of colorectal cancers, we here investigated the associatio... | Lack of Absent in Melanoma 2 (AIM2) expression in tumor cells is closely associated with poor survival in colorectal cancer patients. |
{"1001": 0.42416930198669434, "1009": 0.31132611632347107, "1011": 0.09584271162748337, "1014": 0.18411032855510712, "1017": 0.5827828645706177, "1019": 0.0797421783208847, "1023": 0.0913962796330452, "1052": 0.36358460783958435, "1058": 0.21372433006763458, "1999": 0.16110190749168396, "2003": 0.16359257698059082, "20... | 42782688 | BACKGROUND Alkaline sphingomyelinase, an enzyme found exclusively in bile and the intestinal brush border, hydrolyzes sphingomyelin into ceramide, sphingosine and sphingosine-1-phosphate, thereby inducing epithelial apoptosis. Reduced levels of alkaline sphingomyelinase have been found in premalignant and malignant int... | VSL#3 probiotic upregulates intestinal mucosal alkaline sphingomyelinase and reduces inflammation. |
{"1011": 0.18978065252304077, "1044": 0.13157635927200317, "1998": 0.026025565341114998, "2002": 0.9271688461303711, "2007": 0.2954642176628113, "2015": 0.07341018319129944, "2025": 0.1358480453491211, "2029": 0.319873183965683, "2033": 0.6543170213699341, "2039": 0.3622259199619293, "2051": 0.10993985831737518, "2084"... | 42787108 | Lineage-specific differentiation potential varies among different human pluripotent stem cell (hPSC) lines, becoming therefore highly desirable to prospectively know which hPSC lines exhibit the highest differentiation potential for a certain lineage. We have compared the hematopoietic potential of 14 human embryonic s... | Nodal/Activin signaling predicts human pluripotent stem cell lines prone to differentiate toward the hematopoietic lineage. |
{"1014": 0.19862671196460724, "1016": 0.036437395960092545, "1017": 0.12470348179340363, "1020": 0.043007105588912964, "1021": 0.06703783571720123, "1022": 0.10467668622732162, "1023": 0.18816383183002472, "1040": 0.11430477350950241, "1041": 0.18329764902591705, "1045": 0.0019512200960889459, "1049": 0.080643489956855... | 42800527 | BACKGROUND Adverse effects of metformin are primarily related to gastrointestinal (GI) intolerance that could limit titration to an efficacious dose or cause discontinuation of the medication. Because some metformin side effects may be attributable to shifts in the GI microbiome, we tested whether a GI microbiome modul... | Addition of a Gastrointestinal Microbiome Modulator to Metformin Improves Metformin Tolerance and Fasting Glucose Levels. |
{"1011": 0.33675122261047363, "1015": 0.11256109178066254, "1019": 0.20501139760017395, "1022": 0.34023189544677734, "1047": 1.0437490940093994, "1051": 0.6970458030700684, "2000": 0.18329764902591705, "2029": 0.16442140936851501, "2035": 0.3956514894962311, "2046": 0.03266380727291107, "2048": 0.39762192964553833, "20... | 42836872 | This study was undertaken to analyze genetic alterations in 108 sporadic serous ovarian neoplasms to elucidate ovarian serous carcinogenesis. Our results demonstrate that K-ras mutations occur in approximately 50% of serous borderline tumors (SBTs), non-invasive micropapillary serous carcinomas (MPSCs), and invasive mi... | Diverse tumorigenic pathways in ovarian serous carcinoma. |
{"1011": 0.32905077934265137, "1041": 0.9100211262702942, "1043": 0.7201237678527832, "1999": 0.08782484382390976, "2008": 0.006812678650021553, "2010": 0.2539152204990387, "2013": 0.16276304423809052, "2029": 0.26146242022514343, "2046": 0.10731173306703568, "2072": 1.1281205415725708, "2098": 0.06154331564903259, "21... | 42855554 | To clarify the fate of glycosylphosphatidylinositol (GPI) in mammals, we developed GPI-anchored enhanced green fluorescent protein (EGFP-GPI) and transgenic mice carrying this fusion construct. When it was introduced to culture cells, the EGFP-GPI protein was correctly sorted to plasma membranes and microsomes dependin... | Tissue-inherent fate of GPI revealed by GPI-anchored GFP transgenesis. |
{"1011": 0.20739519596099854, "1016": 0.24171993136405945, "1017": 0.07612881064414978, "1022": 0.06429435312747955, "1039": 0.40546512603759766, "1040": 0.1212492436170578, "1043": 0.5301685929298401, "1050": 0.17431432008743286, "1055": 0.7710843086242676, "1996": 0.3077431619167328, "1999": 0.11256109178066254, "200... | 42865134 | The SANT domain is a novel motif found in a number of eukaryotic transcriptional regulatory proteins that was identified based on its homology to the DNA binding domain of c-myb. Here we show that the SANT domain is essential for the in vivo functions of yeast Swi3p, Ada2p, and Rsc8p, subunits of three distinct chromat... | Essential role for the SANT domain in the functioning of multiple chromatin remodeling enzymes. |
{"1011": 0.15526613593101501, "1015": 0.7463917136192322, "1016": 0.7665573358535767, "1017": 0.2822965085506439, "1050": 0.7629209756851196, "1156": 0.5313173532485962, "1164": 0.4151833653450012, "1998": 0.052318159490823746, "2011": 0.2719337046146393, "2015": 0.3005385100841522, "2028": 0.347847044467926, "2029": 0... | 42873134 | Type 1 and type 2 diabetes are characterized by progressive beta-cell failure. Apoptosis is probably the main form of beta-cell death in both forms of the disease. It has been suggested that the mechanisms leading to nutrient- and cytokine-induced beta-cell death in type 2 and type 1 diabetes, respectively, share the a... | Mechanisms of pancreatic beta-cell death in type 1 and type 2 diabetes: many differences, few similarities. |
{"1014": 0.4974553883075714, "1016": 0.1718502640724182, "1017": 0.28743788599967957, "1018": 0.16110190749168396, "1019": 0.3269403576850891, "1026": 0.01934296265244484, "1044": 0.05970508232712746, "1048": 0.6086184978485107, "1052": 0.259204238653183, "1053": 0.8691008687019348, "1997": 0.5903874635696411, "2001": ... | 42913391 | BACKGROUND The objective was to quantify the health-related quality of life (HRQL) of children treated for acute lymphoblastic leukemia (ALL) and identify specific disabilities for remediation. PROCEDURE Two types of subjects were included: ALL patients 5 plus years old in a multi-center clinical trial and general popu... | Health-related quality of life among children with acute lymphoblastic leukemia. |
{"1044": 0.4067663550376892, "2012": 0.20580662786960602, "2013": 0.03925827145576477, "2015": 0.24018502235412598, "2020": 0.05417001247406006, "2037": 0.034552380442619324, "2043": 0.06154331564903259, "2044": 0.39762192964553833, "2048": 0.083342544734478, "2051": 0.00875066313892603, "2071": 0.23402166366577148, "2... | 42944505 | The change in avian clutch size with latitude is a celebrated example of geographic variation in a vertebrate life-history trait. Alternative hypotheses for this pattern invoke nest predation, limited food for nestlings, or post-fledging juvenile mortality as selection pressures leading to small clutch size of tropical... | JUVENILE MORTALITY INCREASES WITH CLUTCH SIZE IN A NEOTROPICAL BIRD |
{"1003": 0.09495500475168228, "1017": 0.23479416966438293, "2005": 0.29473719000816345, "2007": 0.24018502235412598, "2029": 0.14602625370025635, "2031": 0.1734936386346817, "2043": 0.04860413447022438, "2048": 0.08603433519601822, "2064": 0.11604541540145874, "2065": 0.2711893916130066, "2093": 0.5914691090583801, "21... | 42950029 | Rotator cuff tears account for almost 50% of major shoulder injuries but are sometimes difficult to diagnose. To aid diagnosis, we did a prospective study, comparing results of 23 clinical tests from 400 patients with and without rotator cuff tears. Three simple tests were predictive for rotator cuff tear: supraspinatu... | Diagnosis of rotator cuff tears. |
{"1052": 0.36426326632499695, "1058": 0.018384648486971855, "1060": 0.8592242002487183, "2008": 0.10203468054533005, "2011": 0.2983669638633728, "2013": 0.0770333781838417, "2025": 0.3177432417869568, "2029": 0.04767346754670143, "2031": 0.037378571927547455, "2035": 0.012615402229130268, "2038": 0.055094651877880096, ... | 43014661 | Xeroderma pigmentosum variant (XPV) patients with mutations in the DNA polymerase eta (pol eta) gene are hypersensitive to sunlight and have greatly increased susceptibility to sunlight-induced skin cancer. Consistent with the ability of Pol eta to efficiently bypass UV light-induced cyclobutane pyrimidine dimers, XPV ... | Increased susceptibility to UV-induced skin carcinogenesis in polymerase eta-deficient mice. |
{"1006": 0.016465263441205025, "1009": 0.42990362644195557, "1011": 0.2719337046146393, "1016": 0.3241194784641266, "1017": 0.07341018319129944, "1039": 0.5232481360435486, "1041": 0.6128603219985962, "1043": 0.3163207769393921, "1044": 0.6312094330787659, "1047": 0.0174254160374403, "1048": 0.19782574474811554, "1050"... | 43048059 | AIMS The present study aims to investigate the interaction between nitric oxide (NO) and hydrogen sulfide (H(2)S), the two important gaseous mediators in rat hearts. METHODS AND RESULTS Intracellular calcium in isolated cardiomyocytes was measured with a spectrofluorometric method using Fura-2. Myocyte contractility wa... | Hydrogen sulfide interacts with nitric oxide in the heart: possible involvement of nitroxyl. |
{"1011": 0.18573370575904846, "1048": 0.5232481360435486, "1050": 0.09672962874174118, "1055": 0.25694093108177185, "1996": 0.018384648486971855, "1997": 0.14179791510105133, "1999": 0.026976587250828743, "2003": 0.2561853528022766, "2008": 0.026025565341114998, "2011": 0.06795065850019455, "2015": 0.13243216276168823,... | 43054703 | Neutrophil extracellular traps (NETs) are webs of DNA covered with antimicrobial molecules that constitute a newly described killing mechanism in innate immune defense. Previous publications reported that NETs take up to 3-4 h to form via an oxidant-dependent event that requires lytic death of neutrophils. In this stud... | A novel mechanism of rapid nuclear neutrophil extracellular trap formation in response to Staphylococcus aureus. |
{"1017": 0.02792670577764511, "1019": 0.2184450328350067, "1020": 0.23402166366577148, "1044": 0.41840189695358276, "1045": 0.5404602885246277, "1056": 0.045809537172317505, "2001": 0.18167030811309814, "2005": 0.39433568716049194, "2007": 0.06795065850019455, "2029": 0.011650617234408855, "2034": 0.15693697333335876, ... | 43122426 | We studied 201 consecutive patients who received a relatively fixed dose of radioiodine for the treatment of hyperthyroidism between the years 1981-6. Patients with Graves' disease (170) were initially treated with a mean (SE) dose of 369 (10) MBq 131-I with a remission rate of 94% at 6 months and a cumulative relapse ... | 131-I radioiodine therapy for hyperthyroidism in patients with Graves' disease, uninodular goitre and multinodular goitre. |
{"2000": 0.15693697333335876, "2005": 0.18654440343379974, "2012": 0.0752234235405922, "2034": 0.10379679501056671, "2043": 0.04394211992621422, "2044": 0.058784693479537964, "2051": 0.12814582884311676, "2064": 0.37371641397476196, "2076": 0.1970241367816925, "2077": 0.19782574474811554, "2079": 0.1718502640724182, "2... | 43128141 | Timing and route of nutrition provided to critically ill patients can affect their outcome. Early enteral nutrition has been shown to decrease specifically infectious morbidity in the critically ill patient. There is a small group of patients who are malnourished on arrival to the intensive care unit and in these patie... | Enteral nutrition in the critically ill patient. |
{"1011": 0.1710275560617447, "1016": 0.04113444685935974, "1017": 0.319873183965683, "1018": 0.06246116757392883, "1020": 0.1619328260421753, "1044": 0.46853771805763245, "1045": 0.15943801403045654, "2002": 0.19381128251552582, "2005": 0.025073638185858727, "2007": 0.48430517315864563, "2008": 0.05970508232712746, "20... | 43156471 | We have conducted a genomewide investigation into the enzymatic specificity, expression profiles, and binding locations of four histone deacetylases (HDACs), representing the three different phylogenetic classes in fission yeast (Schizosaccharomyces pombe). By directly comparing nucleosome density, histone acetylation ... | Genomewide analysis of nucleosome density histone acetylation and HDAC function in fission yeast. |
{"1019": 0.13499516248703003, "1020": 0.040196798741817474, "1038": 0.5410289764404297, "1041": 0.495672345161438, "1050": 0.5914691090583801, "1055": 0.5685047507286072, "1999": 0.11865071207284927, "2002": 0.817850649356842, "2005": 0.3923587501049042, "2007": 0.007782140281051397, "2011": 0.18654440343379974, "2013"... | 43165768 | OBJECTIVE To investigate the antimicrobial property of mangrove plant Sonneratia alba (S. alba). METHODS The antimicrobial activity was evaluated using disc diffusion and microdilution methods against six microorganisms. Soxhlet apparatus was used for extraction with a series of solvents, n-hexane, ethyl acetate and me... | In vitro antimicrobial activity of mangrove plant Sonneratia alba. |
{"1009": 0.2837681770324707, "1011": 0.04394211992621422, "1039": 0.2501201331615448, "1042": 0.5990082025527954, "1061": 0.6471850275993347, "1999": 0.0354953333735466, "2008": 0.03266380727291107, "2013": 0.20660123229026794, "2015": 0.803087055683136, "2029": 0.21765978634357452, "2043": 0.04674193635582924, "2046":... | 43192375 | Adipose tissue macrophages (ATMs) infiltrate adipose tissue during obesity and contribute to insulin resistance. We hypothesized that macrophages migrating to adipose tissue upon high-fat feeding may differ from those that reside there under normal diet conditions. To this end, we found a novel F4/80(+)CD11c(+) populat... | Obesity induces a phenotypic switch in adipose tissue macrophage polarization. |
{"1018": 0.3423145115375519, "1056": 0.5517725944519043, "1081": 0.1970241367816925, "2044": 0.9842413663864136, "2051": 0.09672962874174118, "2058": 0.3676496744155884, "2061": 0.5127768516540527, "2062": 0.014542185701429844, "2076": 0.20501139760017395, "2086": 0.6181373596191406, "2087": 0.20022670924663544, "2090"... | 43220289 | Extreme obesity is associated with severe psychiatric and somatic comorbidity and impairment of psychosocial functioning. Bariatric surgery is the most effective treatment not only with regard to weight loss but also with obesity-associated illnesses. Health-related psychological and psychosocial variables have been in... | Psychological Outcome 4 Years after Restrictive Bariatric Surgery |
{"1011": 0.4356052577495575, "1015": 0.6317287683486938, "1043": 0.6286086440086365, "1052": 1.004473328590393, "1166": 0.14518201351165771, "1997": 0.1358480453491211, "2006": 0.05694137513637543, "2007": 0.07250232994556427, "2012": 0.1384023278951645, "2028": 0.255429208278656, "2029": 0.22157983481884003, "2047": 0... | 43224840 | P-selectin glycoprotein ligand-1 (PSGL-1) binding to P-selectin mediates leukocyte rolling under conditions of flow. In human neutrophils, a type of leukocyte belonging to the innate immune system, PSGL-1 molecules are located on the neutrophil's surface ruffles, called microvilli. Each newly formed P-selectin-PSGL-1 b... | Dynamics of Microvillus Extension and Tether Formation in Rolling Leukocytes. |
{"1017": 0.1011524572968483, "1049": 0.4400174915790558, "1055": 0.02316705882549286, "2003": 0.040196798741817474, "2007": 0.014542185701429844, "2014": 0.19622190296649933, "2038": 0.08154398202896118, "2042": 0.21214580535888672, "2044": 0.20580662786960602, "2045": 0.3012613356113434, "2053": 0.06977381557226181, "... | 43226130 | Multiple sclerosis (MS), a chronic inflammatory demyelina-ting and degenerative disease of the central nervous system, is a frequent cause of neurological disability in young adults. Female predominance has increased over the last decades. Although female gender carries a higher risk of developing relapsing remitting M... | Female Gender and Reproductive Factors Affecting Risk, Relapses and Progression in Multiple Sclerosis |
{"1016": 0.014542185701429844, "1017": 0.15023678541183472, "1018": 0.1332872211933136, "1020": 0.5110208988189697, "1999": 0.08603433519601822, "2012": 0.04207121208310127, "2013": 0.3995884954929352, "2020": 0.03360854089260101, "2028": 0.18004031479358673, "2048": 0.5010119676589966, "2075": 0.8666408061981201, "209... | 43283375 | Spatial Release from Masking (SRM) was measured for identification of a female target word spoken in the presence of male masker words. Target words from a single loudspeaker located at midline were presented when two, four, or six masker words were presented either from the same source as the target or from spatially ... | Spatial release from masking based on binaural processing for up to six maskers. |
{"1015": 0.5104349255561829, "1043": 0.5461324453353882, "1999": 0.15777134895324707, "2007": 0.06795065850019455, "2015": 0.6000806093215942, "2020": 0.05139094591140747, "2028": 0.28963330388069153, "2042": 0.09938567131757736, "2071": 0.19782574474811554, "2077": 0.14602625370025635, "2080": 0.5909284353256226, "208... | 43311750 | Mutations in the NPHS1 gene cause congenital nephrotic syndrome of the Finnish type presenting before the first 3 months of life. Recently, NPHS1 mutations have also been identified in childhood-onset steroid-resistant nephrotic syndrome and milder courses of disease, but their role in adults with focal segmental glome... | Nephrin mutations cause childhood- and adult-onset focal segmental glomerulosclerosis. |
{"1044": 0.029824240133166313, "1051": 0.5444341897964478, "2003": 0.28082266449928284, "2005": 0.7755908370018005, "2007": 0.021256839856505394, "2019": 0.10291612148284912, "2044": 0.21687394380569458, "2063": 0.520350456237793, "2064": 0.14602625370025635, "2076": 0.16524957120418549, "2078": 0.48430517315864563, "2... | 43329366 | Clomifene is widely used for inducing ovulation.1 It is structurally related to diethylstilbestrol, which has been linked to vaginal and cervical clear cell adenocarcinoma in women exposed in utero. The adverse effect is less severe in sons, although links to testicular cancer and urogenital anomalies, such as epididym... | Use of clomifene during early pregnancy and risk of hypospadias: population based case-control study. |
{"1014": 0.14433705806732178, "1052": 0.4286321699619293, "1055": 0.46670228242874146, "1998": 0.10379679501056671, "2004": 0.9294845461845398, "2007": 0.20660123229026794, "2021": 0.05694137513637543, "2029": 0.10026945173740387, "2060": 0.4145384132862091, "2069": 0.1873544454574585, "2078": 0.09406650811433792, "208... | 43334921 | IMPORTANCE Use of aspirin and other nonsteroidal anti-inflammatory drugs (NSAIDs) is associated with lower risk of colorectal cancer. OBJECTIVE To identify common genetic markers that may confer differential benefit from aspirin or NSAID chemoprevention, we tested gene × environment interactions between regular use of ... | Association of aspirin and NSAID use with risk of colorectal cancer according to genetic variants. |
{"1013": 0.17922431230545044, "1015": 0.6027565002441406, "1018": 0.3012613356113434, "1020": 0.08513788133859634, "1050": 0.11604541540145874, "2004": 0.043007105588912964, "2005": 0.14686977863311768, "2007": 0.13670019805431366, "2028": 0.1946154683828354, "2038": 0.00875066313892603, "2042": 0.0770333781838417, "20... | 43378932 | Topical preexposure prophylaxis interrupts HIV transmission at the site of mucosal exposure. Intermittently dosed vaginal gels containing the HIV-1 reverse transcriptase inhibitor tenofovir protected pigtailed macaques depending on the timing of viral challenge relative to gel application. However, modest or no protect... | Intravaginal ring eluting tenofovir disoproxil fumarate completely protects macaques from multiple vaginal simian-HIV challenges. |
{"1009": 0.5092619061470032, "1011": 0.19862671196460724, "1017": 0.16607704758644104, "1041": 0.1905880719423294, "1999": 0.09938567131757736, "2004": 0.029824240133166313, "2007": 0.25239890813827515, "2008": 0.058784693479537964, "2011": 0.08513788133859634, "2015": 0.38308101892471313, "2026": 0.6000806093215942, "... | 43385013 | It has been proposed that epithelial-mesenchymal transition (EMT) in mammary epithelial cells and breast cancer cells generates stem cell features, and that the presence of EMT characteristics in claudin-low breast tumors reveals their origin in basal stem cells. It remains to be determined, however, whether EMT is an ... | Epithelial and mesenchymal subpopulations within normal basal breast cell lines exhibit distinct stem cell/progenitor properties. |
{"1011": 0.09584271162748337, "1054": 0.38308101892471313, "2003": 0.2105647772550583, "2011": 0.38308101892471313, "2012": 0.4891071021556854, "2029": 0.12470348179340363, "2063": 0.1889725625514984, "2071": 0.10993985831737518, "2076": 0.306306391954422, "2124": 0.347847044467926, "2140": 0.32199856638908386, "2175":... | 43390777 | Macroautophagy, the process by which cytosolic components and organelles are engulfed and degraded by a double-membrane structure, could be viewed as a specialized, multistep membrane transport process. As such, it intersects with the exocytic and endocytic membrane trafficking pathways. A number of Rab GTPases which r... | Involvement of members of the Rab family and related small GTPases in autophagosome formation and maturation |
{"1044": 0.3743882179260254, "1156": 0.6410312056541443, "1998": 0.22548456490039825, "2003": 0.28963330388069153, "2004": 0.24018502235412598, "2007": 0.18492233753204346, "2024": 0.0058422754518687725, "2029": 0.05970508232712746, "2047": 0.8925741910934448, "2054": 0.3464667797088623, "2058": 0.22704219818115234, "2... | 43417006 | New-onset diabetes mellitus (NOD) refers to forms of diabetes mellitus that develop during the therapeutic processes of other diseases such as hypertension. This study has been conducted in a network meta-analysis to compare antihypertensive drugs by identifying both the advantages and disadvantages on NOD by focusing ... | Comparative risk of new-onset diabetes mellitus for antihypertensive drugs: A network meta-analysis. |
{"1011": 0.14433705806732178, "1042": 0.3601844012737274, "1047": 0.7987030148506165, "2003": 0.11256109178066254, "2006": 0.6223390698432922, "2008": 0.1619328260421753, "2011": 0.2786078155040741, "2015": 0.4145384132862091, "2029": 0.3106105625629425, "2033": 0.018384648486971855, "2072": 0.034552380442619324, "2076... | 43419566 | Mitogen-activated protein (MAP) kinase kinase (MAPKK) activates MAP kinase in a signal transduction pathway that mediates cellular responses to growth and differentiation factors. Oncogenes such as ras, src, raf, and mos have been proposed to transform cells by prolonging the activated state of MAPKK and of components ... | Transformation of mammalian cells by constitutively active MAP kinase kinase. |
{"2000": 0.05046287178993225, "2001": 0.0058422754518687725, "2004": 0.8187123537063599, "2005": 0.22079704701900482, "2007": 0.08782484382390976, "2009": 0.0174254160374403, "2015": 0.38574060797691345, "2018": 0.14264501631259918, "2038": 0.056018441915512085, "2040": 0.13499516248703003, "2051": 0.4041621685028076, ... | 43427621 | A 17-year-old boy with frequent faints due to blood-injury phobia was studied. During cardiovascular reflex investigation in our syncope unit, 50 seconds of asystole were recorded. He was treated using systematic desensitization with muscular tension and cognitive techniques by the Pediatric Psychosocial Department and... | Psychological treatment of malignant vasovagal syncope due to bloodphobia. |
{"1044": 0.015504186972975731, "1050": 0.2576959431171417, "1053": 1.286776065826416, "1056": 0.31560876965522766, "2007": 0.32058215141296387, "2013": 0.01934296265244484, "2025": 0.02887592278420925, "2031": 0.04860413447022438, "2043": 0.07250232994556427, "2047": 0.18248429894447327, "2053": 0.5438674688339233, "20... | 43483151 | Patients with non-insulin dependent diabetes mellitus have an excess risk of dying from cardiovascular disease. One small study suggested that a prolonged QT interval could predict cardiac death in patients with diabetic nephropathy who have received insulin treatment. The question now is whether the same is true in ne... | QT and QTc dispersion are accurate predictors of cardiac death in newly diagnosed non-insulin dependent diabetes: cohort study. |
{"1011": 0.4974553883075714, "1015": 0.09850110858678818, "1017": 0.0752234235405922, "1019": 0.1913948506116867, "1023": 0.14095009863376617, "1044": 0.07159364968538284, "1045": 0.07250232994556427, "1056": 0.49626702070236206, "1999": 0.06703783571720123, "2005": 0.14264501631259918, "2010": 0.6102113127708435, "201... | 43534665 | The role of IL-10 in the pathogenesis of autoimmune diabetes mellitus was assessed in the nonobese diabetic (NOD) mouse. In these studies the effect of IL-10 was determined on three parameters of diabetes: The development of hyperglycemia, the development of insulitis, and the production of insulin by beta cells. Initi... | Recombinant human IL-10 prevents the onset of diabetes in the nonobese diabetic mouse. |
{"1040": 0.020300358533859253, "1044": 0.8500841856002808, "1056": 0.1011524572968483, "2002": 0.1913948506116867, "2005": 0.14686977863311768, "2007": 0.27934664487838745, "2029": 0.1510767638683319, "2053": 0.18978065252304077, "2062": 0.25088030099868774, "2064": 0.034552380442619324, "2078": 0.966567873954773, "208... | 43557480 | The aim of this study was the long-term retrospective analysis of chronic kidney disease (CKD) progression in children, especially with regard to the presence of hypertension (HTN). The average rate of progression of CKD was higher in patients with HTN than without HTN. Hypertension treatment requires multidrug schemes... | Arterial hypertension and progression of chronic kidney disease in children during 10-year ambulatory observation. |
{"1011": 0.05139094591140747, "1013": 0.2184450328350067, "1019": 0.006812678650021553, "1038": 0.27342069149017334, "1042": 0.1358480453491211, "1044": 0.401551216840744, "1049": 0.2786078155040741, "1056": 0.7863243818283081, "1059": 0.7201237678527832, "1999": 0.040196798741817474, "2006": 0.18573370575904846, "2012... | 43566999 | This study was designed to determine the influence of a long-term, moderate-intensity treadmill training program on the distribution of blood flow within and among muscles of rats during exercise. One group (T) of male Sprague-Dawley rats trained for 1 h/day for 13-17 wk at 30 m/min on a motor-driven treadmill. A secon... | Exercise blood flow patterns within and among rat muscles after training. |
{"1014": 0.4950772523880005, "1016": 0.31845372915267944, "1022": 0.043007105588912964, "1038": 0.8748174905776978, "1050": 0.11604541540145874, "1052": 0.3297532796859741, "1056": 0.6374238729476929, "1057": 0.012615402229130268, "1998": 0.12814582884311676, "2007": 0.026025565341114998, "2020": 0.09050461649894714, "... | 43587663 | How the infection risks compare after umbilical cord blood (UCB) and bone marrow (BM) transplantation is not known. Therefore, we compared serious infections in the 2 years after pediatric myeloablative unrelated donor transplantation with unmanipulated BM (n = 52), T cell-depleted (TCD) BM (n = 24), or UCB (n = 60) fo... | Serious infections after unrelated donor transplantation in 136 children: impact of stem cell source. |
{"1015": 0.417115718126297, "1050": 1.0423725843429565, "1056": 0.15777134895324707, "1999": 0.22548456490039825, "2008": 0.15610189735889435, "2028": 0.06886265426874161, "2029": 0.1970241367816925, "2036": 0.46424978971481323, "2046": 0.5133614540100098, "2053": 0.07884006202220917, "2075": 0.18004031479358673, "2076... | 43602749 | Chromosome breakage elicits transient silencing of ribosomal RNA synthesis, but the mechanisms involved remained elusive. Here we discover an in trans signalling mechanism that triggers pan-nuclear silencing of rRNA transcription in response to DNA damage. This is associated with transient recruitment of the Nijmegen b... | The NBS1–Treacle complex controls ribosomal RNA transcription in response to DNA damage |
{"1051": 0.5540198087692261, "1054": 0.4286321699619293, "1056": 1.3054782152175903, "2011": 0.4512746334075928, "2029": 0.08871890604496002, "2039": 0.41065993905067444, "2063": 0.436867892742157, "2076": 0.39893341064453125, "2079": 0.2741633653640747, "2080": 0.10467668622732162, "2100": 0.27342069149017334, "2102":... | 43619625 | Activated T cells secrete multiple osteoclastogenic cytokines which play a major role in the bone destruction associated with rheumatoid arthritis. While the role of T cells in osteoclastogenesis has received much attention recently, the effect of T cells on osteoblast formation and activity is poorly defined. In this ... | Inflammatory T cells rapidly induce differentiation of human bone marrow stromal cells into mature osteoblasts. |
{"1009": 0.0009760859538801014, "1014": 0.19622190296649933, "1052": 0.45623743534088135, "1999": 0.2637155055999756, "2004": 0.3019835948944092, "2007": 0.3077431619167328, "2010": 0.03831886500120163, "2026": 0.7629209756851196, "2029": 0.06520967930555344, "2053": 0.4400174915790558, "2078": 0.018384648486971855, "2... | 43629704 | BACKGROUND Lowering the blood cholesterol level may reduce the risk of coronary heart disease. This double-blind study was designed to determine whether the administration of pravastatin to men with hypercholesterolemia and no history of myocardial infarction reduced the combined incidence of nonfatal myocardial infarc... | Prevention of coronary heart disease with pravastatin in men with hypercholesterolemia. West of Scotland Coronary Prevention Study Group. |
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