spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1041": 0.46117570996284485, "1060": 0.5751199722290039, "1998": 0.10026945173740387, "2003": 0.09850110858678818, "2005": 0.11430477350950241, "2024": 0.32341301441192627, "2029": 0.06977381557226181, "2054": 0.026976587250828743, "2064": 0.1930064558982849, "2071": 0.0797421783208847, "2075": 0.29036402702331543, "2... | 39801095 | Embryonic stem cells (ESCs) are pluripotent, self-renewing cells. These cells can be used in applications such as cell therapy, drug development, disease modeling, and the study of cellular differentiation. Investigating the interplay of epigenetics, genetics, and gene expression in control of pluripotence and differen... | DNA methylation in embryonic stem cells. |
{"1011": 0.07159364968538284, "1021": 0.0770333781838417, "1038": 1.0868242979049683, "1050": 0.12038381397724152, "1056": 0.2501201331615448, "1999": 0.009718249551951885, "2002": 0.07431721687316895, "2013": 0.0317181795835495, "2015": 0.7845434546470642, "2025": 0.5255602598190308, "2026": 0.7067264318466187, "2029"... | 39851630 | Defective hematopoiesis supporting capacity of bone marrow (BM) stroma has been implicated in the pathophysiology of myelodysplastic syndromes (MDS). The aim of this study is to explore whether the BM stroma progenitors, namely the mesenchymal stem cells (MSCs), are primarily affected in MDS by evaluating the reserves,... | Reserves, functional, immunoregulatory, and cytogenetic properties of bone marrow mesenchymal stem cells in patients with myelodysplastic syndromes. |
{"1011": 0.17922431230545044, "1052": 0.22157983481884003, "1996": 0.16690383851528168, "2002": 0.1930064558982849, "2004": 0.25467249751091003, "2007": 0.1064341589808464, "2008": 0.05694137513637543, "2010": 0.9425065517425537, "2011": 0.018384648486971855, "2029": 0.24859806895256042, "2049": 0.0058422754518687725, ... | 39859981 | Virulence in Staphylococcus aureus is largely under control of the accessory gene regulator (agr) quorum-sensing system. The AgrC receptor histidine kinase detects its autoinducing peptide (AIP) ligand and generates an intracellular signal resulting in secretion of virulence factors. Although agr is a well-studied quor... | Symmetric signalling within asymmetric dimers of the Staphylococcus aureus receptor histidine kinase AgrC. |
{"1011": 0.2719337046146393, "1015": 0.7500885725021362, "1041": 0.4425300657749176, "1057": 0.9886114001274109, "1997": 0.0009760859538801014, "2000": 0.15023678541183472, "2003": 0.2026219218969345, "2004": 0.01934296265244484, "2005": 0.1889725625514984, "2007": 0.15526613593101501, "2008": 0.17922431230545044, "201... | 39863735 | Urm1p is a ubiquitin-related protein that serves as a posttranslational modification of other proteins. Urm1p conjugation has been implicated in the budding process and in nutrient sensing. Here, we have identified the first in vivo target for the urmylation pathway as the antioxidant protein Ahp1p. The attachment of U... | Attachment of the ubiquitin-related protein Urm1p to the antioxidant protein Ahp1p. |
{"1019": 0.11168810725212097, "1020": 0.176772341132164, "1055": 0.19782574474811554, "1062": 0.5057345628738403, "1999": 0.2561853528022766, "2000": 0.2501201331615448, "2004": 0.0842406153678894, "2005": 0.36494144797325134, "2006": 0.2409527748823166, "2007": 0.21765978634357452, "2020": 0.06795065850019455, "2029":... | 39892135 | OBJECTIVE To assess the efficacy and tolerability of sulfasalazine (SSZ) in the treatment of spondylarthropathy. METHODS We conducted a 6-month randomized, placebo-controlled, double-blind, multicenter study of patients with spondylarthropathy whose disease had remained active despite treatment with nonsteroidal antiin... | Sulfasalazine in the treatment of spondylarthropathy. A randomized, multicenter, double-blind, placebo-controlled study. |
{"1009": 0.3127557039260864, "1014": 0.42735910415649414, "1052": 0.5635144114494324, "2004": 0.9194108247756958, "2034": 0.3949938118457794, "2043": 0.1229778528213501, "2044": 0.4574742913246155, "2047": 0.013579257763922215, "2051": 0.49686139822006226, "2058": 0.0174254160374403, "2062": 0.23092569410800934, "2076"... | 39903312 | BACKGROUND Experimental studies in animals and observational studies in humans suggest that regular aspirin use may decrease the risk of colorectal adenomas, the precursors to most colorectal cancers. METHODS We conducted a randomized, double-blind trial to determine the effect of aspirin on the incidence of colorectal... | A randomized trial of aspirin to prevent colorectal adenomas in patients with previous colorectal cancer. |
{"1009": 0.5984715819358826, "1011": 0.29328158497810364, "1015": 0.5016035437583923, "1017": 0.040196798741817474, "1047": 0.9820492267608643, "1056": 0.36494144797325134, "1059": 1.2655161619186401, "1062": 0.4537591338157654, "2007": 0.5174443125724792, "2008": 0.14349138736724854, "2012": 0.09228714555501938, "2013... | 39929509 | Mutations in WT1 are associated with developmental syndromes that affect the urogenital system and neoplasms, including Wilms tumour, acute myeloid leukemia, and breast and prostate cancers. The WT1 protein belongs to the early growth response family of zinc-finger transcription factors. Uniquely to WT1, an evolutionar... | The Wilms tumour suppressor protein WT1 (+KTS isoform) binds alpha-actinin 1 mRNA via its zinc-finger domain. |
{"1003": 0.25694093108177185, "1998": 0.2317005842924118, "1999": 0.040196798741817474, "2001": 0.15777134895324707, "2005": 0.2501201331615448, "2007": 0.39367714524269104, "2015": 0.18004031479358673, "2020": 0.3127557039260864, "2035": 0.11691460013389587, "2043": 0.0009760859538801014, "2045": 0.14686977863311768, ... | 39970500 | PURPOSE This study assessed psychiatric medications and their potential lethality in a representative sample of suicide attempts. MATERIALS AND METHODS During 1996-98, 563 suicide attempts were studied in a general hospital in Madrid (Spain). Medication overdose was used in 456 suicide attempts (81%). The ratio between... | How safe are psychiatric medications after a voluntary overdose? |
{"1018": 0.4196864068508148, "1039": 0.10203468054533005, "1085": 0.5116065740585327, "2000": 0.1358480453491211, "2005": 0.07793712615966797, "2022": 0.21214580535888672, "2035": 0.006812678650021553, "2040": 0.8764448165893555, "2047": 0.6112717390060425, "2057": 0.015504186972975731, "2065": 0.10203468054533005, "20... | 39984099 | BACKGROUND New WHO guidelines recommend ART initiation for HIV-positive persons with CD4 cell counts ≤500 cells/µL, a higher threshold than was previously recommended. Country decision makers must consider whether to further expand ART eligibility accordingly. METHODS We used multiple independent mathematical models in... | Health benefits, costs, and cost-effectiveness of earlier eligibility for adult antiretroviral therapy and expanded treatment coverage: a combined analysis of 12 mathematical models. |
{"1021": 0.17840765416622162, "1023": 0.14686977863311768, "1040": 0.5784112811088562, "1056": 0.6808650493621826, "1999": 0.28963330388069153, "2004": 0.757441520690918, "2005": 0.2696990668773651, "2006": 0.35128939151763916, "2007": 0.10906458646059036, "2012": 0.0317181795835495, "2018": 0.08064348995685577, "2020"... | 39985001 | We retrospectively studied the long-term (2-year) outcome of 50 consecutive patients admitted to our inpatient headache program because of chronic daily headache (CDH) associated with the overuse of analgesics, ergotamine, or both. They had been detoxified, given repetitive intravenous dihydroergotamine (IV DHE) and pr... | Chronic daily headache: long-term prognosis following inpatient treatment with repetitive IV DHE. |
{"1044": 0.06520967930555344, "1052": 0.5045560002326965, "1053": 0.09495500475168228, "2000": 0.05417001247406006, "2001": 0.0354953333735466, "2002": 0.5404602885246277, "2005": 0.13755162060260773, "2044": 0.021256839856505394, "2063": 0.16690383851528168, "2064": 0.10467668622732162, "2065": 0.03831886500120163, "2... | 40005757 | Serious exposure to the herbicide paraquat usually results in death, either due to gastrointestinal caustic lesions, shock, and acute respiratory distress syndrome or related to the progressive development of pulmonary fibrosis associated with refractory hypoxemia. We report a case of suicidal paraquat ingestion in a 5... | Survival in a case of massive paraquat ingestion. |
{"1011": 0.1685553640127182, "1039": 1.049919843673706, "1043": 0.02316705882549286, "1045": 0.23015019297599792, "1156": 0.5528968572616577, "1996": 0.1693800985813141, "1999": 0.28155985474586487, "2008": 0.1710275560617447, "2011": 0.4374985992908478, "2029": 0.2539152204990387, "2058": 0.2637155055999756, "2063": 0... | 40044800 | The presence of DNA in the cytoplasm of mammalian cells is a danger signal that triggers host immune responses such as the production of type I interferons. Cytosolic DNA induces interferons through the production of cyclic guanosine monophosphate-adenosine monophosphate (cyclic GMP-AMP, or cGAMP), which binds to and a... | Cyclic GMP-AMP synthase is a cytosolic DNA sensor that activates the type I interferon pathway. |
{"1011": 0.26296505331993103, "1038": 0.7172679901123047, "1041": 0.7737906575202942, "1043": 0.1229778528213501, "1053": 0.4770587682723999, "1998": 0.1734936386346817, "2001": 0.03831886500120163, "2007": 0.34577593207359314, "2015": 0.6212902665138245, "2020": 0.129004567861557, "2058": 0.9363996982574463, "2063": 0... | 40078758 | OBJECTIVE The purpose of the current study was to examine the relationship among emotional regulation, emotional overeating, and general eating pathology in a treatment seeking sample of adults with Binge Eating Disorder (BED). METHOD The sample was composed of 326 adults (248 women, 78 men) who were obese and met DSM-... | Eating pathology, emotion regulation, and emotional overeating in obese adults with Binge Eating Disorder. |
{"1011": 0.1212492436170578, "1017": 0.056018441915512085, "1018": 0.010684899985790253, "1019": 0.06703783571720123, "1022": 0.32553088665008545, "1041": 0.7067264318466187, "1044": 0.26820653676986694, "1045": 0.4512746334075928, "1055": 0.3784096837043762, "2003": 0.3027053773403168, "2013": 0.09406650811433792, "20... | 40087494 | Imprinting is an epigenetic modification leading to monoallelic expression of some genes, and disrupted imprinting is believed to be a barrier to human stem cell transplantation, based on studies that suggest that epigenetic marks are unstable in mouse embryonic germ (EG) and embryonic stem (ES) cells. However, stem ce... | Monoallelic expression and methylation of imprinted genes in human and mouse embryonic germ cell lineages. |
{"1009": 0.02316705882549286, "1011": 0.39433568716049194, "1015": 0.026025565341114998, "1039": 0.8780695199966431, "1046": 1.254435658454895, "1047": 0.3177432417869568, "1050": 0.7276995778083801, "2003": 0.12038381397724152, "2008": 0.01934296265244484, "2015": 0.24171993136405945, "2024": 0.22157983481884003, "202... | 40090058 | The c-Jun N-terminal kinases (JNKs) are key regulators of inflammation and interfere with insulin action in cultured cells and whole animals. Obesity increases total JNK activity, and JNK1, but not JNK2, deficiency results in reduced adiposity and improved insulin sensitivity. Interestingly, a higher-than-normal level ... | Functional in vivo interactions between JNK1 and JNK2 isoforms in obesity and insulin resistance. |
{"1011": 0.06703783571720123, "1039": 0.36494144797325134, "1048": 0.7018978595733643, "1056": 0.9485763907432556, "1999": 0.10291612148284912, "2007": 0.10993985831737518, "2029": 0.06703783571720123, "2037": 0.20739519596099854, "2043": 0.17431432008743286, "2051": 0.1734936386346817, "2066": 0.12470348179340363, "20... | 40094786 | Cytotoxic T lymphocytes (CTL) rapidly destroy their targets. Here we show that although target cell death occurs within 5 min of CTL-target cell contact, an immunological synapse similar to that seen in CD4 cells rapidly forms in CTL, with a ring of adhesion proteins surrounding an inner signaling molecule domain. Lyti... | The immunological synapse of CTL contains a secretory domain and membrane bridges. |
{"1009": 0.46486347913742065, "1011": 0.43053874373435974, "1015": 0.417115718126297, "1037": 0.5033760666847229, "1042": 0.6563454270362854, "1045": 0.8091925978660583, "1048": 0.2394166737794876, "1056": 0.680370569229126, "1156": 0.5640701055526733, "1999": 0.010684899985790253, "2011": 0.19622190296649933, "2025": ... | 40096222 | Mice lacking junctional adhesion molecule A (JAM-A, encoded by F11r) exhibit enhanced intestinal epithelial permeability, bacterial translocation, and elevated colonic lymphocyte numbers, yet do not develop colitis. To investigate the contribution of adaptive immune compensation in response to increased intestinal epit... | Compromised intestinal epithelial barrier induces adaptive immune compensation that protects from colitis. |
{"1041": 0.3850763738155365, "1048": 0.2969166338443756, "1049": 0.5341835021972656, "2006": 0.35745587944984436, "2011": 0.1229778528213501, "2042": 0.04113444685935974, "2064": 0.4067663550376892, "2071": 0.1677299439907074, "2077": 0.24631060659885406, "2079": 0.0038986403960734606, "2106": 0.11256109178066254, "210... | 40127292 | Multidrug resistance remains an unresolved problem in clinical oncology. Over a decade ago genes encoding cellular efflux pumps were shown to confer resistance to a broad spectrum of biochemically unrelated anticancer drugs even before the compounds reached their intracellular targets. More recently it has become appar... | Apoptosis and chemoresistance in transgenic cancer models |
{"1011": 0.025073638185858727, "1043": 0.15693697333335876, "1054": 1.0464962720870972, "1999": 0.015504186972975731, "2000": 0.06795065850019455, "2005": 0.03266380727291107, "2007": 0.5145297050476074, "2011": 0.14179791510105133, "2015": 0.05970508232712746, "2029": 0.19622190296649933, "2076": 0.3824150264263153, "... | 40145839 | Targeting the molecular pathways associated with angiogenesis offers great potential in detecting disease pathology using in vivo imaging technologies. Initiation of angiogenesis requires activation and migration of endothelial cells in order for neovascularization to proceed. Endothelial cells associate with the extra... | NC-100717: a versatile RGD peptide scaffold for angiogenesis imaging. |
{"1014": 0.2478361576795578, "1043": 0.24018502235412598, "1052": 0.4926934838294983, "1058": 0.1332872211933136, "1609": 0.23710809648036957, "2007": 0.07431721687316895, "2025": 0.21214580535888672, "2035": 0.03266380727291107, "2044": 0.8893690705299377, "2051": 0.5272908806800842, "2053": 0.5816917419433594, "2072"... | 40156901 | BACKGROUND Acute kidney injury (AKI) after cardiac surgery is associated with increased morbidity and mortality. METHODS We assessed whether statin treatment is associated with a lower incidence of postoperative AKI in 2,104 consecutive patients who underwent coronary artery bypass graft or valve surgery at the Minneap... | Dose-dependent effect of statins on the incidence of acute kidney injury after cardiac surgery. |
{"1011": 0.14518201351165771, "1018": 0.14602625370025635, "1020": 0.29400965571403503, "1041": 0.3923587501049042, "1048": 0.6275664567947388, "1050": 0.22782009840011597, "1052": 0.03831886500120163, "1999": 0.22859740257263184, "2004": 0.1994270235300064, "2005": 0.21687394380569458, "2007": 0.1064341589808464, "201... | 40164383 | CONTEXT Mesenchymal stem cells (MSCs) are under evaluation as a therapy for ischemic cardiomyopathy (ICM). Both autologous and allogeneic MSC therapies are possible; however, their safety and efficacy have not been compared. OBJECTIVE To test whether allogeneic MSCs are as safe and effective as autologous MSCs in patie... | Comparison of allogeneic vs autologous bone marrow–derived mesenchymal stem cells delivered by transendocardial injection in patients with ischemic cardiomyopathy: the POSEIDON randomized trial. |
{"1017": 0.23479416966438293, "1037": 0.07793712615966797, "1996": 0.10026945173740387, "1997": 0.21214580535888672, "2002": 0.24171993136405945, "2005": 0.19220098853111267, "2011": 0.1946154683828354, "2015": 0.026025565341114998, "2037": 0.09938567131757736, "2054": 0.11691460013389587, "2064": 0.33953672647476196, ... | 40212412 | Life forms that have low body mass can hunt for food on the undersurface of branches or along shear cliff faces quite unperturbed by gravity. For larger animals, the hunt for dinner and the struggle to avoid becoming someone else's meal require rapid movement against gravity. This need is met by the lever function of l... | Periosteal bone formation--a neglected determinant of bone strength. |
{"1039": 0.5640701055526733, "1999": 0.1510767638683319, "2004": 0.037378571927547455, "2011": 0.10993985831737518, "2025": 0.004870930220931768, "2029": 0.05046287178993225, "2042": 0.03831886500120163, "2053": 0.5914691090583801, "2079": 0.24325250089168549, "2092": 0.14349138736724854, "2109": 0.13670019805431366, "... | 40232172 | The research on mitochondrial functions in adipocytes has increasingly evidenced that mitochondria plays an important role in the onset and/or progression of obesity and related pathologies. Mitochondrial function in brown adipose tissue (BAT) has been classically assessed by measuring either the levels/activity of mit... | Triglyceride depletion of brown adipose tissue enables analysis of mitochondrial respiratory function in permeabilized biopsies. |
{"1009": 0.5404602885246277, "1011": 0.32058215141296387, "1015": 0.3127557039260864, "1017": 0.1229778528213501, "1021": 0.12642613053321838, "1022": 0.2478361576795578, "1039": 0.6911921501159668, "1044": 0.1619328260421753, "1047": 0.22704219818115234, "1999": 0.15526613593101501, "2002": 1.0305955410003662, "2005":... | 40234452 | Mouse long-term hematopoietic reconstituting cells exist in the c-Kit+Sca-1+Lin- (KSL) cell population; among them, CD34(low/-) cells represent the most highly purified population of hematopoietic stem cells in the adult bone marrow. Here, we demonstrate that retrovirus-mediated transduction of CD34(low/-)c-Kit+Sca-1+L... | HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo. |
{"1022": 0.12728634476661682, "1053": 0.40806588530540466, "1060": 0.7500885725021362, "2003": 0.06246116757392883, "2015": 0.5145297050476074, "2043": 0.25995752215385437, "2051": 0.10026945173740387, "2057": 0.034552380442619324, "2064": 0.2317005842924118, "2075": 0.15777134895324707, "2076": 0.4196864068508148, "20... | 40254495 | Transcript regulation is essential for cell function, and misregulation can lead to disease. Despite technologies to survey the transcriptome, we lack a comprehensive understanding of transcript kinetics, which limits quantitative biology. This is an acute challenge in embryonic development, where rapid changes in gene... | Measuring Absolute RNA Copy Numbers at High Temporal Resolution Reveals Transcriptome Kinetics in Development. |
{"1009": 0.32905077934265137, "1011": 0.3601844012737274, "1015": 0.41195443272590637, "1038": 0.4158279001712799, "1045": 0.1994270235300064, "1056": 0.4196864068508148, "1999": 0.8091925978660583, "2008": 0.026025565341114998, "2011": 0.3353555500507355, "2029": 0.2145126610994339, "2050": 0.5849615335464478, "2063":... | 40312663 | Inflammasome-mediated IL-1beta production is central to the innate immune defects that give rise to certain autoinflammatory diseases and may also be associated with the generation of IL-17-producing CD4(+) T (Th17) cells that mediate autoimmunity. However, the role of the inflammasome in driving adaptive immunity to i... | Inflammasome activation by adenylate cyclase toxin directs Th17 responses and protection against Bordetella pertussis. |
{"1056": 0.1510767638683319, "1998": 0.16276304423809052, "2029": 0.1064341589808464, "2042": 0.05786345899105072, "2043": 0.0797421783208847, "2048": 0.18573370575904846, "2066": 0.44753631949424744, "2075": 0.09495500475168228, "2076": 0.6553317308425903, "2079": 0.043007105588912964, "2129": 0.013579257763922215, "2... | 40323148 | While inflammatory phagocytosis of microbial pathogens and non-inflammatory phagocytosis of apoptotic cells have each been studied extensively, the consequences of innate immune recognition of host cells undergoing apoptosis as a direct result of infection are unclear. In this situation, the innate immune system is con... | Infection and apoptosis as a combined inflammatory trigger. |
{"1006": 0.007782140281051397, "1011": 0.1970241367816925, "1017": 0.3381449282169342, "1018": 0.11865071207284927, "1021": 0.22001366317272186, "1023": 0.23402166366577148, "1030": 0.34508460760116577, "1038": 0.4980490207672119, "1045": 0.7881022095680237, "1048": 0.6487176418304443, "1053": 0.8893690705299377, "1056... | 40323454 | The t(14;19)(q32;q13) involving the IGH@ and BCL3 loci is an infrequent cytogenetic abnormality detected in B-cell malignancies. We describe the clinicopathologic, cytogenetic, and molecular genetic characteristics of 14 cases of chronic lymphocytic leukemia/small lymphocytic lymphoma (CLL/SLL) with t(14;19)(q32;q13). ... | Chronic lymphocytic leukemia with t(14;19)(q32;q13) is characterized by atypical morphologic and immunophenotypic features and distinctive genetic features. |
{"1020": 0.030771657824516296, "2000": 0.09761575609445572, "2005": 0.11778303235769272, "2007": 0.007782140281051397, "2039": 0.39433568716049194, "2043": 0.15359249711036682, "2044": 0.5404602885246277, "2051": 0.5080875158309937, "2053": 0.19220098853111267, "2067": 0.1221139207482338, "2076": 0.3318578004837036, "2... | 40343416 | OBJECTIVE To assess risk factors for gallstone recurrence following non-surgical treatment. DESIGN A prospective follow-up of a multicentre cohort of post-dissolution gallstone patients. SETTING Six gastroenterology units in the UK and Italy. PARTICIPANTS One hundred and sixty-three patients with confirmed gallstone di... | Risk factors for the development of gallstone recurrence following medical dissolution. The British-Italian Gallstone Study Group. |
{"1054": 0.06977381557226181, "1999": 0.12814582884311676, "2010": 0.27044451236724854, "2012": 0.997294545173645, "2053": 0.06703783571720123, "2075": 0.5925496220588684, "2099": 1.094698429107666, "2106": 0.04860413447022438, "2135": 0.03831886500120163, "2188": 0.6291293501853943, "2214": 0.0029254043474793434, "222... | 40349336 | Developmental abnormalities, cancer, and premature aging each have been linked to defects in the DNA damage response (DDR). Mutations in the ATR checkpoint regulator cause developmental defects in mice (pregastrulation lethality) and humans (Seckel syndrome). Here we show that eliminating ATR in adult mice leads to def... | Deletion of the developmentally essential gene ATR in adult mice leads to age-related phenotypes and stem cell loss. |
{"1009": 0.6563454270362854, "1011": 0.04767346754670143, "1048": 0.4709797203540802, "1056": 0.35950297117233276, "1999": 0.0354953333735466, "2004": 0.009718249551951885, "2005": 0.3134697377681732, "2008": 0.0606246218085289, "2015": 0.8731874823570251, "2024": 0.014542185701429844, "2029": 0.3554046154022217, "2035... | 40365566 | Dendritic cells (DCs) are crucial for mounting allergic airway inflammation, but it is unclear which subset of DCs performs this task. By using CD64 and MAR-1 staining, we reliably separated CD11b(+) monocyte-derived DCs (moDCs) from conventional DCs (cDCs) and studied antigen uptake, migration, and presentation assays... | Conventional and monocyte-derived CD11b(+) dendritic cells initiate and maintain T helper 2 cell-mediated immunity to house dust mite allergen. |
{"1011": 0.1889725625514984, "1013": 0.15860503911972046, "1016": 0.06154331564903259, "1017": 0.1685553640127182, "1046": 0.01934296265244484, "1996": 0.24631060659885406, "1997": 0.018384648486971855, "2004": 0.1485546976327896, "2007": 0.13755162060260773, "2011": 0.07431721687316895, "2015": 0.5822374224662781, "20... | 40367499 | How adherens junctions (AJs) are formed upon cell division is largely unexplored. Here, we found that AJ formation is coordinated with cytokinesis and relies on an interplay between the dividing cell and its neighbors. During contraction of the cytokinetic ring, the neighboring cells locally accumulate Myosin II and pr... | Interplay between the dividing cell and its neighbors regulates adherens junction formation during cytokinesis in epithelial tissue. |
{"1039": 0.7370892763137817, "1996": 0.037378571927547455, "2003": 0.08603433519601822, "2011": 0.1602703034877777, "2013": 0.14433705806732178, "2015": 0.052318159490823746, "2024": 0.014542185701429844, "2029": 0.05786345899105072, "2045": 0.17759032547473907, "2135": 0.18329764902591705, "2179": 0.026025565341114998... | 40382183 | Solid tumours are an enormous cancer burden and a major therapeutic challenge. The cancer stem cell (CSC) hypothesis provides an attractive cellular mechanism to account for the therapeutic refractoriness and dormant behaviour exhibited by many of these tumours. There is increasing evidence that diverse solid tumours a... | Cancer stem cells in solid tumours: accumulating evidence and unresolved questions |
{"1011": 0.32905077934265137, "1015": 0.35745587944984436, "1037": 0.4855078160762787, "1038": 0.5584990978240967, "1042": 0.791648268699646, "1045": 0.6533012986183167, "1050": 0.018384648486971855, "1056": 0.9783848524093628, "1156": 0.06703783571720123, "1999": 0.014542185701429844, "2005": 0.09850110858678818, "200... | 40383969 | TGF-beta ligands stimulate diverse cellular differentiation and growth responses by signaling through type I and II receptors. Ligand antagonists, such as follistatin, block signaling and are essential regulators of physiological responses. Here we report the structure of activin A, a TGF-beta ligand, bound to the high... | The structure of the follistatin:activin complex reveals antagonism of both type I and type II receptor binding. |
{"1011": 0.17840765416622162, "1014": 0.4709797203540802, "1015": 0.09050461649894714, "1028": 0.1718502640724182, "1997": 0.16690383851528168, "2004": 0.77198725938797, "2007": 0.07341018319129944, "2011": 0.18492233753204346, "2012": 0.3027053773403168, "2022": 0.018384648486971855, "2029": 0.10467668622732162, "2048... | 40412980 | The biological activity of siRNA seems to be influenced by local characteristics of the target RNA, including local RNA folding. Here, we investigated quantitatively the relationship between local target accessibility and the extent of inhibition of the target gene by siRNA. Target accessibility was assessed by a compu... | The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides. |
{"1011": 0.4002431631088257, "1015": 0.5947071313858032, "1020": 0.09938567131757736, "1043": 0.5472630262374878, "1049": 0.037378571927547455, "1053": 0.23556606471538544, "2004": 0.07159364968538284, "2005": 0.0354953333735466, "2012": 0.052318159490823746, "2028": 0.32764431834220886, "2029": 0.043007105588912964, "... | 40429879 | During the many cell divisions that precede formation of plant gametes, their apical-meristem and floral antecedents are continually exposed to endogenous and environmental mutagenic threats. Although some deleterious recessive mutations may be eliminated during growth of haploid gametophytes and functionally haploid e... | Rapid accumulation of mutations during seed-to-seed propagation of mismatch-repair-defective Arabidopsis. |
{"1011": 0.28890204429626465, "1048": 0.469759464263916, "1056": 0.8517522215843201, "2007": 0.3615458607673645, "2008": 0.1212492436170578, "2010": 0.8238670229911804, "2011": 0.46486347913742065, "2012": 0.42096930742263794, "2015": 0.08513788133859634, "2025": 0.07341018319129944, "2027": 0.08244366943836212, "2029"... | 40447899 | Archaea contain a variety of sequence-independent DNA binding proteins consistent with the evolution of several different, sometimes overlapping and exchangeable solutions to the problem of genome compaction. Some of these proteins undergo residue-specific post-translational lysine acetylation or methylation, hinting a... | Archaeal chromatin and transcription. |
{"1006": 0.0019512200960889459, "1011": 0.35745587944984436, "1018": 0.7592713832855225, "1022": 0.5421652793884277, "1038": 0.5098485946655273, "1039": 0.16276304423809052, "1040": 0.6011518239974976, "1056": 0.8658194541931152, "2011": 0.1889725625514984, "2029": 0.3339579105377197, "2076": 0.35745587944984436, "2084... | 40473317 | In this report, we demonstrate that CD28(-/-) mice are severely impaired in the initial expansion of D(b)/NP366-374-specific CD8 T cells in response to influenza virus infection, whereas 4-1BB ligand (4-1BBL)(-/-) mice show no defect in primary T cell expansion to influenza virus. In contrast, 4-1BBL(-/-) mice show a d... | Temporal segregation of 4-1BB versus CD28-mediated costimulation: 4-1BB ligand influences T cell numbers late in the primary response and regulates the size of the T cell memory response following influenza infection. |
{"1011": 0.06520967930555344, "1049": 0.1401015669107437, "1050": 0.6358738541603088, "2003": 0.4574742913246155, "2008": 0.0019512200960889459, "2011": 0.43244171142578125, "2013": 0.4203280806541443, "2024": 0.11081436276435852, "2029": 0.11778303235769272, "2043": 0.06612417846918106, "2046": 0.30558720231056213, "2... | 40476126 | Anandamide, an endogenous ligand for central cannabinoid receptors, is released from neurons on depolarization and rapidly inactivated. Anandamide inactivation is not completely understood, but it may occur by transport into cells or by enzymatic hydrolysis. The compound N-(4-hydroxyphenyl)arachidonylamide (AM404) was ... | Functional role of high-affinity anandamide transport, as revealed by selective inhibition. |
{"1011": 0.1677299439907074, "1015": 0.030771657824516296, "1016": 0.18167030811309814, "1020": 0.25467249751091003, "1046": 0.0174254160374403, "1055": 0.08064348995685577, "1062": 0.20977331697940826, "2003": 0.4794800877571106, "2005": 0.27564704418182373, "2007": 0.04953393340110779, "2008": 0.02887592278420925, "2... | 40500438 | Silibinin is a flavonoid with antihepatotoxic properties and pleiotropic anticancer capabilities. This study investigated silibinin inhibition of cell invasion by down-regulating matrix metalloproteinase-2 (MMP-2) expression, via attenuation of activator protein-1 (AP-1) in IL-6-stimulated LoVo colon cancer cells. West... | Silibinin inhibits the invasion of IL-6-stimulated colon cancer cells via selective JNK/AP-1/MMP-2 modulation in vitro. |
{"1016": 0.11951763927936554, "1037": 0.16524957120418549, "1057": 0.1485546976327896, "1997": 0.04953393340110779, "2000": 0.004870930220931768, "2007": 0.0606246218085289, "2015": 0.09672962874174118, "2037": 0.15526613593101501, "2046": 0.04674193635582924, "2047": 0.01934296265244484, "2048": 0.49626702070236206, "... | 40500723 | To what degree do immigrants reduce their high rates of residential overcrowding with increasing length of residence in the United States? This question is addressed through the application of a “double cohort” method that nests birth cohorts within immigration cohorts. This method enables duration of immigration effec... | Immigration cohorts and residential overcrowding in southern California |
{"1042": 0.23864774405956268, "1043": 0.9546096324920654, "1057": 0.17020416259765625, "1996": 0.5021947622299194, "1997": 0.1332872211933136, "1998": 0.04767346754670143, "2003": 0.15359249711036682, "2049": 0.2786078155040741, "2064": 0.20102575421333313, "2079": 0.15693697333335876, "2093": 0.2409527748823166, "2129... | 40558887 | The growth and branching of the ureteric bud is a complex process that is ultimately responsible for the organization of the collecting duct system as well as the number of nephrons in the metanephric kidney. While the genes involved in the regulation of this process have begun to be elucidated, our understanding of th... | Expression of green fluorescent protein in the ureteric bud of transgenic mice: a new tool for the analysis of ureteric bud morphogenesis. |
{"1009": 0.5811457633972168, "1011": 0.2741633653640747, "1015": 0.07793712615966797, "1016": 0.7863243818283081, "1019": 0.1477125883102417, "1020": 0.2145126610994339, "1052": 0.5255602598190308, "1056": 0.7163142561912537, "1058": 0.11256109178066254, "1059": 1.020087480545044, "1999": 0.4673144817352295, "2002": 0.... | 40584205 | We used a mouse nasal model of herpes simplex virus 2 (HSV-2) infection to examine the biological properties of HSV-2 wild-type (wt), TK-negative, and replication-defective strains in vivo. Nasal septa tissue is the major site of wt viral replication post intranasal (i.n.) inoculation. The HSV-2 strain 186 syn(+)-1 wt ... | Biological properties of herpes simplex virus 2 replication-defective mutant strains in a murine nasal infection model. |
{"1011": 0.18004031479358673, "1015": 0.012615402229130268, "1017": 0.11343330889940262, "1021": 0.1930064558982849, "1038": 0.05786345899105072, "1041": 0.015504186972975731, "1043": 0.28963330388069153, "1044": 0.09584271162748337, "1048": 0.41389304399490356, "1052": 0.20818853378295898, "1055": 0.6327666640281677, ... | 40590358 | The pro-drug FTY720 is undergoing phase III clinical trials for prevention of allograft rejection. After phosphorylation, FTY720 targets the G protein-coupled-sphingosine-1-phosphate receptor 1 (S1PR1) on lymphocytes, thereby inhibiting their egress from lymphoid organs and their recirculation to inflammatory sites. Po... | The sphingosine-1-phosphate receptor agonist FTY720 modulates dendritic cell trafficking in vivo. |
{"1011": 0.036437395960092545, "1017": 0.255429208278656, "1043": 0.2394166737794876, "1052": 0.5010119676589966, "1055": 0.30486753582954407, "1056": 1.0144377946853638, "2005": 0.23092569410800934, "2008": 0.045809537172317505, "2011": 0.3084607720375061, "2029": 0.26820653676986694, "2044": 0.3084607720375061, "2058... | 40608679 | Sustained signaling from the T cell receptor (TCR) and costimulatory molecules is thought necessary for generating high numbers of effector T cells. Here, we show that Survivin is controlled in peripheral T cells by OX40 cosignaling via sustained PI3k and PKB activation. Survivin is induced by OX40 independent of mitot... | Sustained survivin expression from OX40 costimulatory signals drives T cell clonal expansion. |
{"1014": 0.022212404757738113, "1020": 0.4734157919883728, "1040": 0.46608972549438477, "1044": 0.3910386264324188, "1047": 0.5947071313858032, "1049": 0.04674193635582924, "1052": 0.5860490798950195, "1056": 0.5534584522247314, "1081": 0.8780695199966431, "1998": 0.13755162060260773, "2000": 0.0029254043474793434, "20... | 40631095 | Increased dyspnea and reduced exercise capacity in pulmonary arterial hypertension (PAH) can be partly attributed to impaired respiratory muscle function. This prospective study was designed to assess the impact of exercise and respiratory training on respiratory muscle strength and 6-min walking distance (6MWD) in PAH... | The Combination of Exercise and Respiratory Training Improves Respiratory Muscle Function in Pulmonary Hypertension |
{"1009": 0.5495203733444214, "1011": 0.4425300657749176, "1015": 0.3777405619621277, "1018": 0.46302130818367004, "1045": 0.052318159490823746, "1056": 0.49030399322509766, "1157": 0.33115679025650024, "1998": 0.3416208028793335, "2005": 0.10467668622732162, "2007": 0.06246116757392883, "2011": 0.3381449282169342, "202... | 40632104 | IL-12 and IFN-gamma positively regulate each other and type 1 inflammatory responses, which are believed to cause tissue damage in autoimmune diseases. We investigated the role of the IL-12/IFN-gamma (Th1) axis in the development of autoimmune myocarditis. IL-12p40-deficient mice on a susceptible background resisted my... | Dual role of the IL-12/IFN-gamma axis in the development of autoimmune myocarditis: induction by IL-12 and protection by IFN-gamma. |
{"1040": 0.4938860833644867, "2003": 0.33325836062431335, "2008": 0.034552380442619324, "2011": 0.33675122261047363, "2013": 0.006812678650021553, "2029": 0.083342544734478, "2061": 0.41647201776504517, "2075": 0.3127557039260864, "2076": 0.16607704758644104, "2079": 0.013579257763922215, "2091": 1.3372600078582764, "2... | 40655970 | Arthropod Dscam, the homologue of the human Down Syndrome cell adhesion molecule, is a receptor used by the nervous and immune systems. Unlike in vertebrates, evolutionary pressure has selected and maintained a vast Dscam diversity of isoforms, known to specifying neuronal identity during the nervous system differentia... | Somatic and Germline Diversification of a Putative Immunoreceptor within One Phylum: Dscam in Arthropods. |
{"1053": 0.36697331070899963, "1997": 0.4500300884246826, "2063": 0.34370049834251404, "2100": 0.15359249711036682, "2116": 0.011650617234408855, "2140": 0.43623676896095276, "2149": 0.11517547070980072, "2166": 0.7951818704605103, "2172": 0.45932671427726746, "2213": 0.6410312056541443, "2236": 0.39762192964553833, "2... | 40666943 | PURPOSE To perform a systematic review on the epidemiology, the health-related quality of life (HRQoL) and economic burden of binge eating disorder (BED). METHODS A systematic literature search of English-language articles was conducted using Medline, Embase, PsycINFO, PsycARTICLES, Academic Search Complete, CINAHL Plu... | Epidemiology, health-related quality of life and economic burden of binge eating disorder: a systematic literature review |
{"1011": 0.23864774405956268, "1013": 0.1693800985813141, "1040": 0.8315495252609253, "1043": 0.7665573358535767, "1996": 0.06977381557226181, "1998": 0.16607704758644104, "2007": 0.2493593990802765, "2011": 0.08782484382390976, "2024": 0.11256109178066254, "2029": 0.25239890813827515, "2035": 0.04767346754670143, "203... | 40667066 | Steroid hormones, thyroid hormones, retinoic acids, and vitamin D bind to their receptors, which are now called steroid/nuclear receptors, and liganded receptors translocate either intracellularly or intranuclearly and form large protein complexes with cofactors to induce or repress gene transcription. Therefore, stero... | Subcellular steroid/nuclear receptor dynamics. |
{"1011": 0.37102460861206055, "1041": 0.2852376699447632, "1056": 0.10291612148284912, "1999": 0.3191637098789215, "2003": 0.176772341132164, "2013": 0.0009760859538801014, "2033": 0.7647408246994019, "2054": 0.06520967930555344, "2060": 0.17759032547473907, "2076": 0.12986256182193756, "2079": 0.129004567861557, "2102... | 40667577 | The metastatic process, i.e. the dissemination of cancer cells throughout the body to seed secondary tumors at distant sites, requires cancer cells to leave the primary tumor and to acquire migratory and invasive capabilities. In a process of epithelial-mesenchymal transition (EMT), besides changing their adhesive repe... | EMT, the cytoskeleton, and cancer cell invasion |
{"1011": 0.10993985831737518, "1021": 0.5844172835350037, "1041": 0.7333439588546753, "1043": 0.8989537954330444, "2007": 0.20739519596099854, "2020": 0.021256839856505394, "2029": 0.1889725625514984, "2037": 0.05046287178993225, "2051": 0.025073638185858727, "2057": 0.34023189544677734, "2087": 0.05046287178993225, "2... | 40710501 | Because a subpopulation of cancer stem cells (tumor-initiating cells, TICs) is believed to be responsible for the development, progression, and recurrence of many tumors, we evaluated the in vitro sensitivity of human glioma TICs to epidermal growth factor receptor (EGFR) kinase inhibitors (erlotinib and gefitinib) and... | Different response of human glioma tumor-initiating cells to epidermal growth factor receptor kinase inhibitors. |
{"1011": 0.5495203733444214, "1015": 0.7426811456680298, "1017": 0.41001203656196594, "1055": 0.3910386264324188, "1061": 1.360074758529663, "1997": 0.3012613356113434, "1999": 0.04767346754670143, "2002": 0.8117979168891907, "2007": 0.5871354341506958, "2008": 0.11168810725212097, "2011": 0.2786078155040741, "2013": 0... | 40721190 | We have previously shown that YB-1 is the only protein of the HEK293 cell cytoplasmic (S100) extract that specifically interacts with RNA hairpins each containing one of the motifs ACCAGCCU (1), CAGUGAGC (2) and UAAUCCCA (3), which had been identified as often found in exosomal RNA and proposed as potential cis-acting ... | Structural features of the interaction of the 3'-untranslated region of mRNA containing exosomal RNA-specific motifs with YB-1, a potential mediator of mRNA sorting. |
{"1998": 0.0029254043474793434, "2001": 0.5364705324172974, "2018": 0.06612417846918106, "2020": 0.37102460861206055, "2022": 0.01934296265244484, "2034": 0.7987030148506165, "2040": 0.0058422754518687725, "2042": 0.020300358533859253, "2043": 0.5393219590187073, "2051": 0.3526630103588104, "2077": 0.015504186972975731... | 40735046 | This paper summarizes the findings of the first breast cancer screening trial, which was initiated in December 1963 to explore the efficacy of screening. Women aged 40-64 years were selected from enrollees in the Health Insurance Plan (HIP) of Greater New York and were randomly assigned to study and control groups. Stu... | Periodic screening for breast cancer: the HIP Randomized Controlled Trial. Health Insurance Plan. |
{"1052": 0.7086513638496399, "2001": 0.45870962738990784, "2003": 0.052318159490823746, "2020": 0.0842406153678894, "2029": 0.06246116757392883, "2034": 0.2531573474407196, "2040": 0.15610189735889435, "2042": 0.05139094591140747, "2043": 0.3269403576850891, "2049": 0.043007105588912964, "2086": 0.004870930220931768, "... | 40754510 | Micrococcus, which, when limited in its extent and activity, causes acute suppurative inflammation (phlegmon), produces, when more extensive and intense in its action on the human system, the most virulent forms of septicaemia and pyaemia.1 In an elegant series of clinical observations and laboratory studies published ... | Staphylococcus aureus infections. |
{"1011": 0.01934296265244484, "2004": 0.022212404757738113, "2005": 0.013579257763922215, "2008": 0.0038986403960734606, "2011": 0.018384648486971855, "2015": 0.2576959431171417, "2024": 0.06703783571720123, "2028": 0.14602625370025635, "2052": 0.007782140281051397, "2064": 0.1064341589808464, "2066": 0.156936973333358... | 40760684 | As ligand-regulated transcription factors, the nuclear hormone receptors are nearly ideal drug targets, with internal pockets that bind to hydrophobic, drug-like molecules and well-characterized ligand-induced conformational changes that recruit transcriptional coregulators to promoter elements. Yet, due to the multitu... | Structural overview of the nuclear receptor superfamily: insights into physiology and therapeutics. |
{"1009": 0.7638313174247742, "1011": 0.20421554148197174, "1015": 0.3443928062915802, "1019": 0.34715715050697327, "1043": 0.3656192123889923, "1046": 0.07159364968538284, "1047": 1.057410478591919, "1054": 0.04394211992621422, "1996": 0.0770333781838417, "1997": 0.0009760859538801014, "1999": 0.16276304423809052, "200... | 40769868 | The inwardly rectifying K+ channel subunit Kir5.1 is expressed abundantly in the brain, but its precise distribution and function are still largely unknown. Because Kir5.1 is co-expressed with Kir4.1 in retinal glial Muller cells, we have compared the biochemical and immunological properties of Kir5.1 and Kir4.1 in the... | Differential assembly of inwardly rectifying K+ channel subunits, Kir4.1 and Kir5.1, in brain astrocytes. |
{"1003": 0.07068414986133575, "1011": 0.06520967930555344, "1051": 0.7389566898345947, "2003": 0.09495500475168228, "2024": 0.026976587250828743, "2031": 0.0019512200960889459, "2053": 0.055094651877880096, "2062": 0.04674193635582924, "2080": 0.08513788133859634, "2084": 0.1332872211933136, "2090": 0.00487093022093176... | 40781557 | Low-grade serous carcinomas represent approximately 10% of all serous ovarian carcinomas. A growing body of research has demonstrated several important differences between the clinical and molecular characteristics of these tumors and those of high-grade serous ovarian carcinomas. Patients with low-grade serous ovarian... | Low-grade serous ovarian cancer: a unique disease. |
{"1009": 0.08064348995685577, "1014": 0.15359249711036682, "1019": 0.1905880719423294, "1043": 0.17020416259765625, "1044": 0.4450363218784332, "1050": 0.5827828645706177, "1062": 0.2493593990802765, "1998": 0.15860503911972046, "2001": 0.02887592278420925, "2002": 0.10906458646059036, "2005": 0.09761575609445572, "200... | 40790033 | BACKGROUND The Avoiding Cardiovascular Events through Combination Therapy in Patients Living with Systolic Hypertension (ACCOMPLISH) trial showed that initial antihypertensive therapy with benazepril plus amlodipine was superior to benazepril plus hydrochlorothiazide in reducing cardiovascular morbidity and mortality. ... | Renal outcomes with different fixed-dose combination therapies in patients with hypertension at high risk for cardiovascular events (ACCOMPLISH): a prespecified secondary analysis of a randomised controlled trial. |
{"1014": 0.417115718126297, "1017": 0.09317722171545029, "1039": 0.151916041970253, "1041": 0.1212492436170578, "1047": 0.6102113127708435, "1053": 0.20818853378295898, "2001": 0.06703783571720123, "2007": 0.06977381557226181, "2041": 0.2822965085506439, "2042": 0.04860413447022438, "2051": 0.3353555500507355, "2076": ... | 40817021 | CONTEXT Findings from previous studies of the effects of exercise training on patient-reported health status have been inconsistent. OBJECTIVE To test the effects of exercise training on health status among patients with heart failure. DESIGN, SETTING, AND PATIENTS Multicenter, randomized controlled trial among 2331 me... | Effects of exercise training on health status in patients with chronic heart failure: HF-ACTION randomized controlled trial. |
{"1014": 0.11256109178066254, "1052": 0.2674594223499298, "1058": 0.27712854743003845, "1081": 0.6674286723136902, "2000": 0.05046287178993225, "2001": 0.06520967930555344, "2005": 0.11604541540145874, "2007": 0.28155985474586487, "2011": 0.2539152204990387, "2029": 0.016465263441205025, "2044": 0.02316705882549286, "2... | 40867854 | In uncontrolled studies, noninvasive positive pressure ventilation (NPPV) was found useful in avoiding endotracheal intubation in patients with acute respiratory failure (ARF) caused by severe community-acquired pneumonia (CAP). We conducted a prospective, randomized study comparing standard treatment plus NPPV deliver... | Acute respiratory failure in patients with severe community-acquired pneumonia: a prospective randomized evaluation of noninvasive ventilation. |
{"1011": 0.3346569836139679, "1015": 0.2539152204990387, "1017": 0.006812678650021553, "1039": 0.8264343738555908, "1041": 0.5021947622299194, "1043": 0.5301685929298401, "1050": 0.5197699069976807, "1997": 0.17431432008743286, "2002": 0.09584271162748337, "2010": 0.7809720039367676, "2013": 0.11865071207284927, "2028"... | 40900242 | Nuclear holoploid genome sizes (C-values) have been estimated to vary about 800-fold in angiosperms, with the smallest established 1C-value of 157 Mbp recorded in Arabidopsis thaliana. In the highly specialized carnivorous family Lentibulariaceae now three taxa have been found that exhibit significantly lower values: G... | Smallest angiosperm genomes found in lentibulariaceae, with chromosomes of bacterial size. |
{"1003": 0.23479416966438293, "1015": 0.0317181795835495, "1042": 0.3423145115375519, "1050": 0.2478361576795578, "1052": 0.7295845746994019, "1999": 0.034552380442619324, "2007": 0.28450319170951843, "2012": 0.39893341064453125, "2013": 0.49864232540130615, "2020": 0.11430477350950241, "2029": 0.175953671336174, "2058... | 40900567 | The multiplication rates and invasiveness of Plasmodium falciparum parasites isolated from adult Thai patients hospitalized with uncomplicated malaria (n=34) were compared with those from persons with severe malaria (n=42). To simulate severe malaria and control for host effects, the in vitro cultures were adjusted to ... | Parasite multiplication potential and the severity of Falciparum malaria. |
{"1040": 0.08064348995685577, "1044": 0.2674594223499298, "1052": 0.5455666780471802, "2003": 0.255429208278656, "2005": 0.06429435312747955, "2011": 0.13925230503082275, "2012": 0.8731874823570251, "2029": 0.09850110858678818, "2044": 0.06520967930555344, "2076": 0.1011524572968483, "2079": 0.053244512528181076, "2083... | 40901687 | The DNA damage response (DDR) is a complex regulatory network that is critical for maintaining genome integrity. Posttranslational modifications are widely used to ensure strict spatiotemporal control of signal flow, but how the DDR responds to environmental cues, such as changes in ambient oxygen tension, remains poor... | PHD3-dependent hydroxylation of HCLK2 promotes the DNA damage response. |
{"1017": 0.10731173306703568, "1021": 0.44566190242767334, "1053": 0.011650617234408855, "1061": 0.45499902963638306, "1997": 0.025073638185858727, "1999": 0.2696990668773651, "2000": 0.1734936386346817, "2006": 0.2954642176628113, "2012": 0.3850763738155365, "2043": 0.1384023278951645, "2044": 0.3824150264263153, "205... | 40905302 | OBJECTIVE Our objective was to assess the cost implications of changing the intensive care unit staffing model from on-demand presence to mandatory 24-hr in-house critical care specialist presence. DESIGN A pre-post comparison was undertaken among the prospectively assessed cohorts of patients admitted to our medical i... | Economic implications of nighttime attending intensivist coverage in a medical intensive care unit. |
{"1011": 0.3547199070453644, "1014": 0.2696990668773651, "1016": 0.06612417846918106, "1017": 0.2983669638633728, "1018": 0.49626702070236206, "1021": 0.14264501631259918, "1023": 0.0913962796330452, "1026": 0.07341018319129944, "1044": 0.4926934838294983, "1045": 0.13071982562541962, "1047": 0.42353010177612305, "1052... | 40913091 | Objective: To evaluate the frequency of α -gene, s-gene, and hemoglobin variant numbers in subjects with Microcytic hypochromic anemia. Methodology: In total out of 850, 340 subjects with microcytic hypochromic anemia [MCV<80fl; MCH<27pg] from Southwest part of Iran, were studied in Research Center of Thalassemia and H... | GENOTYPING OF THALASSEMIA IN MICROCYTIC HYPOCHROMIC ANEMIA PATIENTS FROM SOUTHWEST REGION OF IRAN |
{"1017": 0.0770333781838417, "1019": 0.010684899985790253, "1039": 0.2409527748823166, "1041": 0.6482070088386536, "1051": 0.10555581003427505, "2007": 0.022212404757738113, "2020": 0.03360854089260101, "2028": 0.06795065850019455, "2042": 0.18248429894447327, "2045": 0.08513788133859634, "2062": 0.006812678650021553, ... | 40935722 | BACKGROUND Exacerbations of COPD (ECOPD) remain a major cause of mortality and morbidity. Despite advances in the understanding of their pathophysiology, their assessment relies primarily on clinical presentation, which can be variable and difficult to predict. A large number of biomarkers already have been assessed in... | Systemic biomarkers in exacerbations of COPD: the evolving clinical challenge. |
{"1003": 0.1677299439907074, "1038": 0.6911921501159668, "1041": 0.5180262327194214, "1998": 0.029824240133166313, "2007": 0.0009760859538801014, "2041": 0.31560876965522766, "2044": 0.8837352395057678, "2058": 0.2394166737794876, "2063": 0.14602625370025635, "2064": 0.20102575421333313, "2076": 0.01934296265244484, "2... | 40949706 | Obesity affects 32% of adults in the USA. Surgery generates substantial weight loss, but 20–30% fails to achieve successful weight loss. Our objective was to identify preoperative psychosocial factors associated with weight loss following bariatric surgery. We performed a literature search of PubMed® and the Cochrane D... | Preoperative Predictors of Weight Loss Following Bariatric Surgery: Systematic Review |
{"1011": 0.20977331697940826, "1042": 0.21765978634357452, "1050": 0.1212492436170578, "1056": 0.0354953333735466, "1996": 0.03925827145576477, "1998": 0.0354953333735466, "2003": 0.05786345899105072, "2008": 0.06795065850019455, "2015": 0.3177432417869568, "2024": 0.02316705882549286, "2029": 0.22548456490039825, "203... | 40963697 | The family of tumor necrosis factor receptors (TNFRs) and their ligands form a regulatory signaling network that controls immune responses. Various members of this receptor family respond differently to the soluble and membrane-bound forms of their respective ligands. However, the determining factors and underlying mol... | The tumor necrosis factor receptor stalk regions define responsiveness to soluble versus membrane-bound ligand. |
{"1011": 0.09672962874174118, "1013": 0.0752234235405922, "1059": 0.0317181795835495, "1060": 1.0151457786560059, "1061": 0.3283478021621704, "1062": 1.0423725843429565, "2029": 0.1477125883102417, "2037": 0.010684899985790253, "2038": 0.0913962796330452, "2075": 0.0174254160374403, "2079": 0.23787821829319, "2090": 0.... | 40971746 | Intensive study of a few genetically tractable species with XX/XY sex chromosomes has produced generalizations about the process of sex chromosome dosage compensation that do not fare well when applied to ZZ/ZW sex chromosome systems, such as those in birds. The inherent sexual imbalance in dose of sex chromosome genes... | A bird's-eye view of sex chromosome dosage compensation. |
{"1011": 0.34508460760116577, "1016": 0.7047978043556213, "1017": 0.3346569836139679, "1038": 0.07793712615966797, "1039": 0.08603433519601822, "1048": 0.3019835948944092, "2003": 0.04113444685935974, "2005": 0.09228714555501938, "2014": 0.49982786178588867, "2015": 0.495672345161438, "2029": 0.14602625370025635, "2048... | 40987633 | Charged multivesicular body protein 2B (CHMP2B) - a component of the endosomal complex required for transport-III (ESCRT-III) - is responsible for the vital membrane deformation functions in autophagy and endolysosomal trafficking. A dominant mutation in CHMP2B (CHMP2BIntron5) is associated with a subset of heritable f... | The role of CHMP2BIntron5 in autophagy and frontotemporal dementia. |
{"1048": 0.026025565341114998, "1054": 1.2215901613235474, "1998": 0.3127557039260864, "2005": 0.07159364968538284, "2007": 0.5324648022651672, "2015": 0.14264501631259918, "2031": 0.07341018319129944, "2058": 0.347847044467926, "2064": 0.26446542143821716, "2071": 0.18573370575904846, "2079": 0.45870962738990784, "208... | 40996863 | STUDY OBJECTIVE To review evidence on the association between restless legs syndrome (RLS) and attention-deficit/hyperactivity disorder (ADHD), to discuss the hypothetical mechanisms underlying this association, and to consider the potential interest for common pharmacologic treatments of RLS and ADHD when co-occurring... | Restless legs syndrome and attention-deficit/hyperactivity disorder: a review of the literature. |
{"1011": 0.29473719000816345, "1022": 0.012615402229130268, "1045": 0.6634125709533691, "1047": 0.28670501708984375, "1997": 0.040196798741817474, "2029": 0.24554696679115295, "2046": 0.18816383183002472, "2062": 0.5092619061470032, "2064": 0.15359249711036682, "2075": 0.48670899868011475, "2084": 0.5995445251464844, "... | 41022628 | Using a substrate measuring deletion or inversion of an I-SceI-excised fragment and both accurate and inaccurate rejoining, we determined the impact of non-homologous end-joining (NHEJ) on mammalian chromosome rearrangements. Deletion is 2- to 8-fold more efficient than inversion, independent of the DNA ends structure.... | Impact of the KU80 pathway on NHEJ-induced genome rearrangements in mammalian cells. |
{"1011": 0.11343330889940262, "1016": 0.4462870955467224, "1017": 0.757441520690918, "1020": 0.06429435312747955, "1021": 0.058784693479537964, "1022": 0.058784693479537964, "1041": 0.1011524572968483, "1049": 0.1221139207482338, "1050": 0.025073638185858727, "1056": 0.6916812658309937, "1062": 1.12938392162323, "1997"... | 41024260 | Classical C2H2 zinc finger proteins are among the most abundant transcription factors found in eukaryotes, and the mechanisms through which they recognize their target genes have been extensively investigated. In general, a tandem array of three fingers separated by characteristic TGERP links is required for sequence-s... | The multi-zinc finger protein ZNF217 contacts DNA through a two-finger domain. |
{"1016": 0.4568560719490051, "2000": 0.03925827145576477, "2001": 0.08064348995685577, "2006": 0.1221139207482338, "2018": 0.03831886500120163, "2020": 0.11778303235769272, "2041": 0.06429435312747955, "2048": 0.49686139822006226, "2055": 0.28963330388069153, "2090": 0.2105647772550583, "2106": 0.16607704758644104, "21... | 41074251 | BACKGROUND Knowledge, attitudes, and risk perception in relation to second primary cancer (SPC) screening and their impact on screening practices in cancer survivors are largely unknown. METHODS A total of 326 cancer survivors who had completed primary treatment for cancer >1 year previously were recruited from 6 oncol... | Knowledge, attitudes, risk perception, and cancer screening behaviors among cancer survivors. |
{"1039": 0.3084607720375061, "1054": 0.47827014327049255, "1061": 0.8600510358810425, "2003": 0.29036402702331543, "2008": 0.16359257698059082, "2011": 0.08961215615272522, "2029": 0.2317005842924118, "2035": 0.06154331564903259, "2050": 0.46914875507354736, "2128": 0.1677299439907074, "2139": 0.176772341132164, "2179"... | 41087952 | RIA1 (YNL163c) is a quasi-essential gene that encodes a protein with strong similarities to elongation factors 2. Small C-terminal deletions in the protein lead to a severe growth defect. In the case of a 22-residue C-terminal deletion this can be suppressed by intragenic mutations in the RIA1 gene or dominant extragen... | Ria1p (Ynl163c), a protein similar to elongation factors 2, is involved in the biogenesis of the 60S subunit of the ribosome in Saccharomyces cerevisiae |
{"1998": 0.3241194784641266, "2002": 0.0009760859538801014, "2003": 0.040196798741817474, "2058": 0.3676496744155884, "2089": 0.07884006202220917, "2114": 0.06246116757392883, "2291": 0.8534175157546997, "2303": 0.1994270235300064, "2339": 0.3683255612850189, "2492": 0.13755162060260773, "2515": 0.14939609169960022, "2... | 41120293 | Obesity and insulin resistance are associated with chronic inflammation in metabolic tissues such as adipose tissue and the liver. Recently, growing evidence has implicated the intestinal immune system as an important contributor to metabolic disease. Obesity predisposes to altered intestinal immunity and is associated... | The Intestinal Immune System in Obesity and Insulin Resistance. |
{"1022": 0.12470348179340363, "1048": 0.2659635543823242, "1050": 0.5209306478500366, "1998": 0.1873544454574585, "1999": 0.13414156436920166, "2005": 0.27934664487838745, "2007": 0.006812678650021553, "2012": 0.1619328260421753, "2028": 0.04767346754670143, "2029": 0.319873183965683, "2043": 0.2247048318386078, "2044"... | 41131087 | Human placental lactogen and unconjugated estriol concentrations in maternal serum were evaluated in 100 uneventful twin pregnancies, and these values were compared with those observed in 16 twin pregnancies associated with intrauterine growth retardation or single intrauterine fetal death. In pregnancies associated wi... | Human placental lactogen and unconjugated estriol concentrations in twin pregnancy: monitoring of fetal development in intrauterine growth retardation and single intrauterine fetal death. |
{"1003": 0.053244512528181076, "1038": 0.2652147710323334, "1043": 0.5092619061470032, "1051": 0.41840189695358276, "1055": 0.22782009840011597, "1062": 0.630689799785614, "1999": 0.08603433519601822, "2006": 0.016465263441205025, "2008": 0.007782140281051397, "2011": 0.08871890604496002, "2012": 0.026976587250828743, ... | 41133176 | Using a sensitive Northern blot hybridization technique, gene expression of superoxide dismutase (SOD), catalase, and glutathione peroxidase was studied in pancreatic islets and for comparison in various other mouse tissues (liver, kidney, brain, lung, skeletal muscle, heart muscle, adrenal gland, and pituitary gland).... | Low antioxidant enzyme gene expression in pancreatic islets compared with various other mouse tissues. |
{"1011": 0.14518201351165771, "1015": 0.04953393340110779, "1039": 0.5973974466323853, "1040": 0.38041436672210693, "1052": 0.436867892742157, "1999": 0.11168810725212097, "2012": 0.13499516248703003, "2029": 0.30558720231056213, "2060": 0.04113444685935974, "2063": 1.2364475727081299, "2099": 0.371698260307312, "2110"... | 41159361 | To understand changes in cyclic nucleotide metabolism in muscle disease states, the expression of phosphodiesterase (PDE) isozymes in normal mouse leg muscle was examined. Four subcellular fractions were generated by differential centrifugation at 10,000 x g and 100,000 x g. cAMP PDE activity was found predominately in... | Cyclic nucleotide phosphodiesterase isozymes expressed in mouse skeletal muscle. |
{"1015": 0.4709797203540802, "1044": 0.4518963396549225, "1058": 0.11343330889940262, "1998": 0.30989447236061096, "2007": 0.1677299439907074, "2011": 0.3676496744155884, "2012": 0.38174858689308167, "2028": 0.175953671336174, "2029": 0.08782484382390976, "2035": 0.0058422754518687725, "2044": 0.6139179468154907, "2076... | 41161366 | The effect of exercise on ventilatory function was studied in 7 patients with asthma. Three showed appreciable decrease in forced expiratory volume in one second (FEV 1) after exercise. The degree of hyperventilation produced by exercise correlated with the postexercise decrease in FEV 1. Voluntary hyperventilation at ... | Exercise-induced asthma. |
{"1011": 0.018384648486971855, "1015": 0.1734936386346817, "1038": 0.35060185194015503, "2003": 0.38308101892471313, "2005": 0.10291612148284912, "2008": 0.10291612148284912, "2011": 0.27044451236724854, "2013": 0.08782484382390976, "2024": 0.5318912267684937, "2034": 0.27342069149017334, "2037": 0.056018441915512085, ... | 41165286 | Bacteroidales are the most abundant Gram-negative bacteria of the human intestinal microbiota comprising more than half of the bacteria in many individuals. Some of the factors that these bacteria use to establish and maintain themselves in this ecosystem are beginning to be identified. However, ecological competition,... | An antimicrobial protein of the gut symbiont Bacteroides fragilis with a MACPF domain of host immune proteins. |
{"1017": 0.11604541540145874, "1021": 0.1905880719423294, "1997": 0.11168810725212097, "2001": 0.16607704758644104, "2012": 0.25845035910606384, "2014": 0.0317181795835495, "2019": 0.3963087201118469, "2020": 0.2852376699447632, "2034": 0.623910129070282, "2035": 0.12556517124176025, "2037": 0.10555581003427505, "2048"... | 41182002 | The perception of spatially distributed sound sources was investigated by conducting two listening experiments in anechoic conditions with 13 loudspeakers evenly distributed in the frontal horizontal plane emitting incoherent noise signals. In the first experiment, widely distributed sound sources with gaps in their di... | Directional perception of distributed sound sources. |
{"1011": 0.12728634476661682, "1048": 0.49030399322509766, "1056": 1.2134976387023926, "2000": 0.020300358533859253, "2003": 0.3416208028793335, "2005": 0.3339579105377197, "2064": 0.33115679025650024, "2071": 0.06520967930555344, "2079": 0.025073638185858727, "2102": 0.35745587944984436, "2109": 0.1477125883102417, "2... | 41226276 | Adoptive T cell transfer for cancer and chronic infection is an emerging field that shows promise in recent trials. Synthetic-biology-based engineering of T lymphocytes to express high-affinity antigen receptors can overcome immune tolerance, which has been a major limitation of immunotherapy-based strategies. Advances... | Adoptive T cell transfer for cancer immunotherapy in the era of synthetic biology. |
{"1018": 0.4537591338157654, "1019": 0.5871354341506958, "2005": 0.037378571927547455, "2022": 0.22704219818115234, "2039": 0.0770333781838417, "2043": 0.3949938118457794, "2051": 0.9317949414253235, "2086": 0.45499902963638306, "2095": 0.16607704758644104, "2109": 0.36900100111961365, "2116": 0.2539152204990387, "2146... | 41233511 | The Bruce treadmill protocol is suitable for children as young as age 4 years. Maximal endurance time may be used as the sole criterion of exercise capacity, and normal values were established with 327 children having an innocent heart murmur. Mean endurance time in boys increased from 10.4 minutes at age 4 to 5 years,... | Bruce treadmill test in children: normal values in a clinic population. |
{"1048": 0.8600510358810425, "1054": 0.7342816591262817, "1999": 0.15442965924739838, "2006": 0.18816383183002472, "2007": 0.319873183965683, "2012": 0.24859806895256042, "2025": 0.0009760859538801014, "2029": 0.3810817003250122, "2049": 0.20818853378295898, "2062": 0.12814582884311676, "2066": 0.1751343309879303, "207... | 41239107 | In this study, we investigated the presence and role of immunoproteasome and its LMP2 subunit polymorphism at codon 60 in Alzheimer's disease (AD). Immunoproteasome was present in brain areas such as hippocampus and cerebellum and localized in neurons, astrocytes and endothelial cells. A higher expression of immunoprot... | Immunoproteasome and LMP2 polymorphism in aged and Alzheimer's disease brains. |
{"1011": 0.07068414986133575, "1017": 0.151916041970253, "1051": 0.6543170213699341, "1062": 0.6848117709159851, "1157": 0.026976587250828743, "1996": 0.30558720231056213, "1997": 0.14939609169960022, "1999": 0.18978065252304077, "2005": 0.17759032547473907, "2011": 0.3012613356113434, "2012": 0.25845035910606384, "201... | 41256402 | Neither the restoration of the centrosome during fertilization nor its reduction during gametogenesis is fully understood, but both are pivotal events in development. During each somatic cell cycle, the chromosomes, cytoplasm, and centrosomes duplicate in interphase, and all three split in two during each cell division... | The centrosome and its mode of inheritance: the reduction of the centrosome during gametogenesis and its restoration during fertilization. |
{"1009": 0.05786345899105072, "1018": 0.15610189735889435, "1019": 0.08871890604496002, "1022": 0.0038986403960734606, "1044": 0.2741633653640747, "1998": 0.11256109178066254, "2007": 0.5528968572616577, "2012": 0.011650617234408855, "2020": 0.06703783571720123, "2053": 0.053244512528181076, "2062": 0.3339579105377197,... | 41264017 | BACKGROUND The prevalence of Alzheimer disease (AD) is increasing in the elderly, and vascular risk factors may increase its risk. OBJECTIVE To explore the association of the aggregation of vascular risk factors with AD. METHODS The authors followed 1,138 individuals without dementia at baseline (mean age 76.2) for a m... | Aggregation of vascular risk factors and risk of incident Alzheimer disease. |
{"1017": 0.37035053968429565, "1038": 0.020300358533859253, "1043": 1.0437490940093994, "1044": 0.5151132941246033, "1047": 0.5244048833847046, "2003": 0.3683255612850189, "2008": 0.07068414986133575, "2010": 0.6312094330787659, "2024": 0.037378571927547455, "2029": 0.28743788599967957, "2048": 0.35813871026039124, "20... | 41293601 | Glioblastoma (GBM) is a brain tumor that carries a dismal prognosis and displays considerable heterogeneity. We have recently identified recurrent H3F3A mutations affecting two critical amino acids (K27 and G34) of histone H3.3 in one-third of pediatric GBM. Here, we show that each H3F3A mutation defines an epigenetic ... | Hotspot mutations in H3F3A and IDH1 define distinct epigenetic and biological subgroups of glioblastoma. |
{"1043": 0.5080875158309937, "1052": 0.4812922179698944, "1053": 0.20977331697940826, "2001": 0.17840765416622162, "2003": 0.4067663550376892, "2004": 0.013579257763922215, "2005": 0.07612881064414978, "2020": 0.16359257698059082, "2043": 0.151916041970253, "2072": 0.4926934838294983, "2095": 0.10906458646059036, "2102... | 41294031 | BACKGROUND Paraquat is an effective and widely used herbicide but is also a lethal poison. In many developing countries paraquat is widely available and inexpensive, making poisoning prevention difficult. However most of the people who become poisoned from paraquat have taken it as a means of suicide. Standard treatmen... | Glucocorticoid with cyclophosphamide for paraquat-induced lung fibrosis. |
{"1011": 0.17759032547473907, "1044": 0.5174443125724792, "1050": 0.08782484382390976, "2002": 1.4046790599822998, "2003": 0.1064341589808464, "2005": 0.21214580535888672, "2010": 0.3339579105377197, "2015": 1.0430610179901123, "2018": 0.13499516248703003, "2020": 0.0174254160374403, "2024": 0.20818853378295898, "2032"... | 41298619 | BACKGROUND Hydroxyethyl starches (HES) are synthetic colloids commonly used for fluid resuscitation, yet controversy exists about their impact on kidney function. OBJECTIVES To examine the effects of HES on kidney function compared to other fluid resuscitation therapies in different patient populations. SEARCH STRATEGY... | Hydroxyethyl starch (HES) versus other fluid therapies: effects on kidney function. |
{"1044": 0.13670019805431366, "1998": 0.1913948506116867, "2004": 0.2822965085506439, "2042": 0.026025565341114998, "2058": 0.03925827145576477, "2062": 0.02316705882549286, "2070": 0.036437395960092545, "2075": 0.3070250153541565, "2090": 0.13157635927200317, "2106": 0.015504186972975731, "2109": 0.24631060659885406, ... | 41310252 | The epidemiological evidence that a high-fat diet promotes the development of obesity is considered suggestive but not definitive. The purpose of this paper is to provide a review of various epidemiological methods that have been used to address this issue as well as an updated summary of the existing evidence. Ecologi... | Dietary fat and obesity: evidence from epidemiology. |
{"1011": 0.06246116757392883, "1041": 0.08244366943836212, "1048": 0.1212492436170578, "1997": 0.14939609169960022, "2015": 0.28082266449928284, "2028": 0.12642613053321838, "2029": 0.12038381397724152, "2039": 0.14179791510105133, "2048": 0.2607102394104004, "2079": 0.22937409579753876, "2083": 0.6233867406845093, "21... | 41314611 | Numerous agents attack DNA, forming lesions that impair normal replication. Specialized DNA polymerases transiently replace the replicative polymerase and copy past lesions, thus generating mutations, the major initiating cause of cancer. We monitored, in Escherichia coli, the kinetics of replication of both strands of... | Uncoupling of leading- and lagging-strand DNA replication during lesion bypass in vivo. |
{"1011": 0.28082266449928284, "1017": 0.8707374930381775, "1038": 0.3903779089450836, "1047": 0.6654226183891296, "1052": 0.7638313174247742, "1170": 0.06886265426874161, "2004": 0.014542185701429844, "2005": 0.401551216840744, "2008": 0.021256839856505394, "2011": 0.18492233753204346, "2015": 0.2830325961112976, "2024... | 41325555 | Abstract Phosphoinositide 3-kinases (PI3Ks) are central to the control of cell growth, proliferation and survival, and drive the progression of tumours by activating phosphoinositide-dependent kinase, protein kinase B and the target of rapamycin. Other downstream effectors link PI3K to cell motility and the control of ... | Phosphoinositide 3-kinase signalling--which way to target? |
{"1038": 0.7163142561912537, "1042": 0.4654768109321594, "1052": 0.27786844968795776, "1053": 0.4914994537830353, "1062": 0.7239188551902771, "1997": 0.09672962874174118, "2000": 0.08513788133859634, "2001": 0.09228714555501938, "2012": 0.08513788133859634, "2029": 0.0174254160374403, "2043": 0.14939609169960022, "2044... | 41329220 | The heads of mouse spermatozoa obtained 5 min after release from the excised caudae epididymides showed a characteristic fluorescence pattern in the presence of the fluorophore chlortetracycline (CTC). There was uniform fluorescence over the entire head with about half the sperm population showing a brighter line of fl... | Determination of the time course of capacitation in mouse spermatozoa using a chlortetracycline fluorescence assay. |
{"1011": 0.2674594223499298, "1015": 0.05786345899105072, "1017": 0.07341018319129944, "1018": 0.38174858689308167, "1040": 0.5584990978240967, "1047": 0.46486347913742065, "1054": 0.3723714053630829, "1055": 0.7942996621131897, "1999": 0.040196798741817474, "2001": 0.07793712615966797, "2005": 0.11081436276435852, "20... | 41329906 | OBJECTIVE To detect clustered regularly interspaced short palindromic repeats (CRISPR) in Shigella, and to analyze its relationship to drug resistance. METHODS Four pairs of primers were used for the detection of convincing CRISPR structures CRISPR-S2 and CRISPR-S4, questionable CRISPR structures CRISPR-S1 and CRISPR-S... | [Detection of CRISPR and its relationship to drug resistance in Shigella]. |
{"1011": 0.040196798741817474, "1040": 0.3883931338787079, "1045": 0.2145126610994339, "1050": 0.5110208988189697, "1060": 0.40351006388664246, "1164": 0.6064908504486084, "2002": 0.6420594453811646, "2004": 0.040196798741817474, "2005": 0.053244512528181076, "2007": 0.07612881064414978, "2008": 0.14686977863311768, "2... | 41337677 | The recognition of pathogenic DNA is important to the initiation of antiviral responses. Here we report the identification of DDX41, a member of the DEXDc family of helicases, as an intracellular DNA sensor in myeloid dendritic cells (mDCs). Knockdown of DDX41 expression by short hairpin RNA blocked the ability of mDCs... | The helicase DDX41 senses intracellular DNA mediated by the adaptor STING in dendritic cells |
{"1014": 0.03925827145576477, "1019": 0.0174254160374403, "1020": 0.1358480453491211, "1021": 0.13157635927200317, "1043": 0.8957691192626953, "1056": 0.06337817758321762, "2000": 0.16110190749168396, "2001": 0.06703783571720123, "2005": 0.18978065252304077, "2007": 0.06977381557226181, "2010": 0.52266925573349, "2034"... | 41340212 | BACKGROUND Glioblastoma, the most common primary brain tumor in adults, is usually rapidly fatal. The current standard of care for newly diagnosed glioblastoma is surgical resection to the extent feasible, followed by adjuvant radiotherapy. In this trial we compared radiotherapy alone with radiotherapy plus temozolomid... | Radiotherapy plus concomitant and adjuvant temozolomide for glioblastoma. |
{"1043": 0.083342544734478, "1051": 0.9820492267608643, "1998": 0.3409265875816345, "2006": 0.08692999184131622, "2007": 0.6317287683486938, "2015": 0.08692999184131622, "2025": 0.23247487843036652, "2040": 0.09495500475168228, "2042": 0.1913948506116867, "2060": 0.3588210940361023, "2064": 0.18167030811309814, "2071":... | 41354899 | OBJECTIVE To evaluate the evidence on possible drug interactions between antibiotics and oral contraceptives (OCs) that may lead to OC failure. DATA SOURCES MEDLINE and Lexis/Nexis Medical Library searches for 1966-1999 using the key word "oral contraceptives," cross-indexed with the terms "antibiotics," "adverse effec... | Drug interactions between oral contraceptives and antibiotics. |
{"1042": 0.6254787445068359, "1044": 0.3084607720375061, "1049": 0.6123310327529907, "1996": 0.10906458646059036, "1998": 0.7038320899009705, "2011": 0.1905880719423294, "2013": 0.26146242022514343, "2015": 0.058784693479537964, "2020": 0.2394166737794876, "2029": 0.13499516248703003, "2035": 0.23092569410800934, "2043... | 41380943 | During embryonic development, gonadal steroid hormones (androgens and estrogens) are thought to organize the sexual differentiation of the brain in the heterogametic sexes of higher vertebrates (males in mammals, females in birds). Brain differentiation of the homogametic sexes is thought to proceed by default, not req... | Male Japanese quails with female brains do not show male sexual behaviors. |
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