spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1039": 0.23556606471538544, "1040": 0.12384103983640671, "1046": 0.49626702070236206, "1048": 0.15023678541183472, "1049": 0.18492233753204346, "1055": 0.3012613356113434, "2003": 0.4974553883075714, "2004": 0.1751343309879303, "2007": 0.29109421372413635, "2012": 0.8500841856002808, "2013": 0.32270604372024536, "201... | 4399268 | Spinal muscular atrophy is one of the most common inherited forms of neurological disease leading to infant mortality. Patients have selective loss of lower motor neurons resulting in muscle weakness, paralysis and often death. Although patient fibroblasts have been used extensively to study spinal muscular atrophy, mo... | Induced pluripotent stem cells from a spinal muscular atrophy patient |
{"1017": 0.5871354341506958, "1040": 0.32905077934265137, "1048": 0.20660123229026794, "1050": 0.11517547070980072, "1996": 0.21293537318706512, "1999": 0.6773988008499146, "2004": 0.42608439922332764, "2006": 0.06612417846918106, "2011": 0.28890204429626465, "2015": 0.7665573358535767, "2019": 0.18411032855510712, "20... | 4399311 | An inflammatory response initiated by the NLRP3 inflammasome is triggered by a variety of situations of host ‘danger’, including infection and metabolic dysregulation. Previous studies suggested that NLRP3 inflammasome activity is negatively regulated by autophagy and positively regulated by reactive oxygen species (RO... | A role for mitochondria in NLRP3 inflammasome activation |
{"1011": 0.34715715050697327, "1158": 0.6075552701950073, "2003": 0.11951763927936554, "2005": 0.1602703034877777, "2011": 0.5139457583427429, "2012": 0.255429208278656, "2029": 0.0038986403960734606, "2075": 0.11778303235769272, "2076": 0.09850110858678818, "2079": 0.15023678541183472, "2083": 0.319873183965683, "2094... | 4401289 | Homology-directed DNA repair is essential for genome maintenance through templated DNA synthesis. Alternative lengthening of telomeres (ALT) necessitates homology-directed DNA repair to maintain telomeres in about 10–15% of human cancers. How DNA damage induces assembly and execution of a DNA replication complex (break... | Break-induced telomere synthesis underlies alternative telomere maintenance |
{"1011": 0.42353010177612305, "1015": 0.15359249711036682, "1017": 0.08692999184131622, "1039": 0.9900637865066528, "1044": 0.17840765416622162, "1045": 0.6363908052444458, "1155": 0.10026945173740387, "1156": 0.0354953333735466, "2002": 1.072225570678711, "2003": 0.2160874605178833, "2004": 0.08782484382390976, "2005"... | 4402497 | Innate immune defences are essential for the control of virus infection and are triggered through host recognition of viral macromolecular motifs known as pathogen-associated molecular patterns (PAMPs). Hepatitis C virus (HCV) is an RNA virus that replicates in the liver, and infects 200 million people worldwide. Infec... | Innate immunity induced by composition-dependent RIG-I recognition of hepatitis C virus RNA |
{"1037": 0.0842406153678894, "1038": 0.14264501631259918, "1996": 0.01934296265244484, "2003": 0.18492233753204346, "2005": 0.2719337046146393, "2008": 0.15023678541183472, "2011": 0.03360854089260101, "2015": 0.04860413447022438, "2024": 0.043007105588912964, "2038": 0.15359249711036682, "2042": 0.025073638185858727, ... | 4404433 | The common marmoset (Callithrix jacchus) is increasingly attractive for use as a non-human primate animal model in biomedical research. It has a relatively high reproduction rate for a primate, making it potentially suitable for transgenic modification. Although several attempts have been made to produce non-human tran... | Generation of transgenic non-human primates with germline transmission |
{"1011": 0.1212492436170578, "1017": 0.4400174915790558, "1999": 0.5104349255561829, "2000": 0.029824240133166313, "2004": 0.5557019114494324, "2005": 0.022212404757738113, "2007": 0.12038381397724152, "2011": 0.40285754203796387, "2013": 0.3269403576850891, "2022": 0.02412080205976963, "2026": 0.6244332790374756, "203... | 4405194 | Somatic cell nuclear transfer, cell fusion, or expression of lineage-specific factors have been shown to induce cell-fate changes in diverse somatic cell types. We recently observed that forced expression of a combination of three transcription factors, Brn2 (also known as Pou3f2), Ascl1 and Myt1l, can efficiently conv... | Induction of human neuronal cells by defined transcription factors |
{"1011": 0.36967599391937256, "1020": 0.8748174905776978, "1052": 0.04207121208310127, "1055": 0.3012613356113434, "1056": 1.0382318496704102, "1058": 0.8091925978660583, "1996": 0.16359257698059082, "2003": 0.2837681770324707, "2005": 0.09761575609445572, "2008": 0.016465263441205025, "2011": 0.31489628553390503, "201... | 4406819 | The bacterial type VI secretion system (T6SS) is a large multicomponent, dynamic macromolecular machine that has an important role in the ecology of many Gram-negative bacteria. T6SS is responsible for translocation of a wide range of toxic effector molecules, allowing predatory cells to kill both prokaryotic as well a... | PAAR-repeat proteins sharpen and diversify the Type VI secretion system spike |
{"1009": 0.5370414853096008, "1011": 0.176772341132164, "1017": 0.1913948506116867, "1022": 0.24248650670051575, "1039": 0.1889725625514984, "1055": 0.2786078155040741, "2006": 0.8091925978660583, "2012": 0.12556517124176025, "2013": 0.20421554148197174, "2015": 0.9333322048187256, "2063": 0.5244048833847046, "2071": 0... | 4407318 | Oncogene-induced DNA replication stress has been implicated as a driver of tumorigenesis. Many chromosomal rearrangements characteristic of human cancers originate from specific regions of the genome called common fragile sites (CFSs). CFSs are difficult-to-replicate loci that manifest as gaps or breaks on metaphase ch... | Replication stress activates DNA repair synthesis in mitosis |
{"1008": 0.2231435477733612, "1011": 0.0913962796330452, "1017": 0.17020416259765625, "1020": 0.5461324453353882, "1047": 0.7683706283569336, "1056": 0.77198725938797, "1156": 0.8400169610977173, "2007": 0.014542185701429844, "2013": 0.15943801403045654, "2015": 0.10026945173740387, "2029": 0.0842406153678894, "2043": ... | 4407385 | Memory function often declines with age, and is believed to deteriorate initially because of changes in synaptic function rather than loss of neurons. Some individuals then go on to develop Alzheimer's disease with neurodegeneration. Here we use Tg2576 mice, which express a human amyloid-β precursor protein (APP) varia... | A specific amyloid-β protein assembly in the brain impairs memory |
{"1011": 0.2689530849456787, "1015": 0.6043586730957031, "1018": 0.37371641397476196, "1019": 0.18411032855510712, "1039": 0.37371641397476196, "1040": 0.33605360984802246, "1043": 0.28963330388069153, "1050": 0.3127557039260864, "1052": 0.6160298585891724, "1597": 0.15359249711036682, "1999": 0.401551216840744, "2005"... | 4407455 | Inflammatory caspases (caspase-1, -4, -5 and -11) are critical for innate defences. Caspase-1 is activated by ligands of various canonical inflammasomes, and caspase-4, -5 and -11 directly recognize bacterial lipopolysaccharide, both of which trigger pyroptosis. Despite the crucial role in immunity and endotoxic shock,... | Cleavage of GSDMD by inflammatory caspases determines pyroptotic cell death |
{"1011": 0.025073638185858727, "2005": 0.14179791510105133, "2007": 0.1619328260421753, "2012": 0.4002431631088257, "2019": 0.8400169610977173, "2029": 0.05970508232712746, "2036": 0.39893341064453125, "2075": 0.41065993905067444, "2076": 0.17020416259765625, "2077": 0.1510767638683319, "2079": 0.09672962874174118, "20... | 4409524 | In pregnancy, trophoblast invasion and uterine spiral artery remodelling are important for lowering maternal vascular resistance and increasing uteroplacental blood flow. Impaired spiral artery remodelling has been implicated in pre-eclampsia, a major complication of pregnancy, for a long time but the underlying mechan... | Role of corin in trophoblast invasion and uterine spiral artery remodelling in pregnancy |
{"1011": 0.14939609169960022, "1015": 0.025073638185858727, "1017": 0.2034190446138382, "1028": 0.15442965924739838, "1040": 0.4190443754196167, "1042": 0.09672962874174118, "1043": 0.36426326632499695, "1051": 0.46914875507354736, "1999": 0.0842406153678894, "2011": 0.21765978634357452, "2013": 0.037378571927547455, "... | 4410181 | Mitochondria have a major role in energy production via oxidative phosphorylation, which is dependent on the expression of critical genes encoded by mitochondrial (mt)DNA. Mutations in mtDNA can cause fatal or severely debilitating disorders with limited treatment options. Clinical manifestations vary based on mutation... | Metabolic rescue in pluripotent cells from patients with mtDNA disease |
{"1015": 0.34508460760116577, "1052": 0.3903779089450836, "1996": 0.176772341132164, "1997": 0.14264501631259918, "1999": 0.021256839856505394, "2002": 0.7295845746994019, "2003": 0.07341018319129944, "2006": 0.10291612148284912, "2007": 0.1401015669107437, "2008": 0.29109421372413635, "2011": 0.40546512603759766, "201... | 4411655 | Telomeres are the physical ends of eukaryotic chromosomes. Genetic studies have established that the baker's yeast Pif1p DNA helicase is a negative regulator of telomerase, the specialized reverse transcriptase that maintains telomeric DNA, but the biochemical basis for this inhibition was unknown. Here we show that in... | The yeast Pif1p helicase removes telomerase from telomeric DNA |
{"1011": 0.30558720231056213, "1016": 0.07250232994556427, "1017": 0.3012613356113434, "1050": 0.10026945173740387, "1051": 0.056018441915512085, "1997": 0.09406650811433792, "1999": 0.08603433519601822, "2008": 0.056018441915512085, "2011": 0.33675122261047363, "2012": 0.19220098853111267, "2015": 0.4909018874168396, ... | 4411760 | Eukaryotic cells express a wide variety of endogenous small regulatory RNAs that regulate heterochromatin formation, developmental timing, defence against parasitic nucleic acids and genome rearrangement. Many small regulatory RNAs are thought to function in nuclei. For instance, in plants and fungi, short interfering ... | Small regulatory RNAs inhibit RNA Polymerase II during the elongation phase of transcription |
{"1015": 0.22782009840011597, "1017": 0.0770333781838417, "1018": 0.1751343309879303, "1020": 0.14349138736724854, "1039": 0.34922540187835693, "1041": 0.3318578004837036, "1047": 0.4067663550376892, "1999": 0.06886265426874161, "2004": 0.06337817758321762, "2005": 0.11517547070980072, "2006": 0.0317181795835495, "2008... | 4412772 | Unicellular organisms such as yeasts require a single cyclin-dependent kinase, Cdk1, to drive cell division. In contrast, mammalian cells are thought to require the sequential activation of at least four different cyclin-dependent kinases, Cdk2, Cdk3, Cdk4 and Cdk6, to drive cells through interphase, as well as Cdk1 to... | Cdk1 is sufficient to drive the mammalian cell cycle |
{"1052": 0.823009729385376, "2000": 0.09761575609445572, "2003": 0.08961215615272522, "2005": 0.045809537172317505, "2011": 0.2105647772550583, "2029": 0.15777134895324707, "2054": 0.2786078155040741, "2063": 0.29619070887565613, "2064": 0.2969166338443756, "2069": 0.3622259199619293, "2076": 0.26446542143821716, "2078... | 4414481 | Calorie restriction (CR) extends lifespan in a wide spectrum of organisms and is the only regimen known to lengthen the lifespan of mammals. We established a model of CR in budding yeast Saccharomyces cerevisiae. In this system, lifespan can be extended by limiting glucose or by reducing the activity of the glucose-sen... | Calorie restriction extends Saccharomyces cerevisiae lifespan by increasing respiration |
{"1011": 0.10379679501056671, "1015": 0.17759032547473907, "1048": 0.4879087805747986, "1051": 0.5313173532485962, "1052": 0.7791815400123596, "1997": 0.0019512200960889459, "2020": 0.13925230503082275, "2029": 0.18492233753204346, "2035": 0.33115679025650024, "2041": 0.1946154683828354, "2047": 0.129004567861557, "207... | 4414547 | Improved sequencing technologies offer unprecedented opportunities for investigating the role of rare genetic variation in common disease. However, there are considerable challenges with respect to study design, data analysis and replication. Using pooled next-generation sequencing of 507 genes implicated in the repair... | Mosaic PPM1D mutations are associated with predisposition to breast and ovarian cancer |
{"1011": 0.12986256182193756, "1020": 0.6139179468154907, "1038": 0.6970458030700684, "1039": 0.08244366943836212, "1041": 0.6317287683486938, "1056": 0.5086748600006104, "1999": 0.2231435477733612, "2005": 0.1221139207482338, "2011": 0.36426326632499695, "2013": 0.42353010177612305, "2015": 0.5795059204101562, "2020":... | 4416964 | Induced pluripotent stem cells (iPSCs), reprogrammed from somatic cells with defined factors, hold great promise for regenerative medicine as the renewable source of autologous cells. Whereas it has been generally assumed that these autologous cells should be immune-tolerated by the recipient from whom the iPSCs are de... | Immunogenicity of induced pluripotent stem cells |
{"1011": 0.020300358533859253, "2005": 0.11604541540145874, "2013": 0.2478361576795578, "2029": 0.0354953333735466, "2036": 0.24631060659885406, "2064": 0.23633737862110138, "2075": 0.06337817758321762, "2079": 0.045809537172317505, "2109": 0.20580662786960602, "2110": 0.2160874605178833, "2128": 0.21922965347766876, "... | 4417177 | As is the case for embryo-derived stem cells, application of reprogrammed human induced pluripotent stem cells is limited by our understanding of lineage specification. Here we demonstrate the ability to generate progenitors and mature cells of the haematopoietic fate directly from human dermal fibroblasts without esta... | Direct conversion of human fibroblasts to multilineage blood progenitors |
{"1011": 0.18654440343379974, "1042": 0.7537717819213867, "2003": 0.016465263441205025, "2008": 0.0174254160374403, "2015": 0.29619070887565613, "2024": 0.2696990668773651, "2029": 0.03360854089260101, "2031": 0.0058422754518687725, "2037": 0.17020416259765625, "2057": 0.016465263441205025, "2061": 0.09406650811433792,... | 4417558 | How instructive cues present on the cell surface have their precise effects on the actin cytoskeleton is poorly understood. Semaphorins are one of the largest families of these instructive cues and are widely studied for their effects on cell movement, navigation, angiogenesis, immunology and cancer. Semaphorins/collap... | Mical links semaphorins to F-actin disassembly |
{"1011": 0.1485546976327896, "1017": 0.36358460783958435, "1051": 0.018384648486971855, "1052": 0.5255602598190308, "1056": 0.7934166193008423, "2008": 0.08154398202896118, "2011": 0.4196864068508148, "2029": 0.2145126610994339, "2065": 0.09584271162748337, "2079": 0.19541899859905243, "2080": 0.9915141463279724, "2102... | 4418070 | Regulatory T (Treg) cells, characterized by expression of the transcription factor forkhead box P3 (Foxp3), maintain immune homeostasis by suppressing self-destructive immune responses. Foxp3 operates as a late-acting differentiation factor controlling Treg cell homeostasis and function, whereas the early Treg-cell-lin... | Novel Foxo1-dependent transcriptional programs control Treg cell function |
{"1011": 0.11430477350950241, "1999": 0.1212492436170578, "2005": 0.27712854743003845, "2011": 0.12384103983640671, "2015": 0.040196798741817474, "2026": 0.7565253376960754, "2029": 0.13071982562541962, "2043": 0.07341018319129944, "2044": 0.5232481360435486, "2050": 0.6522845029830933, "2076": 0.5562619566917419, "207... | 4418112 | In mammals, enlargement of the heart during embryonic development is primarily dependent on the increase in cardiomyocyte numbers. Shortly after birth, however, cardiomyocytes stop proliferating and further growth of the myocardium occurs through hypertrophic enlargement of the existing myocytes. As a consequence of th... | Functional screening identifies miRNAs inducing cardiac regeneration |
{"1011": 0.09228714555501938, "1017": 0.3163207769393921, "1040": 0.6451379656791687, "1996": 0.04113444685935974, "1998": 0.2223619967699051, "2007": 0.5393219590187073, "2008": 0.0038986403960734606, "2011": 0.40285754203796387, "2029": 0.16607704758644104, "2031": 0.00875066313892603, "2048": 0.07884006202220917, "2... | 4418269 | Spinal reflexes are mediated by synaptic connections between sensory afferents and motor neurons. The organization of these circuits shows several levels of specificity. Only certain classes of proprioceptive sensory neurons make direct, monosynaptic connections with motor neurons. Those that do are bound by rules of m... | Specificity of sensory–motor connections encoded by Sema3e–Plxnd1 recognition |
{"1011": 0.09672962874174118, "1055": 0.7248653769493103, "1996": 0.06795065850019455, "1997": 0.043007105588912964, "1999": 0.6482070088386536, "2002": 0.7239188551902771, "2008": 0.011650617234408855, "2011": 0.3499138653278351, "2015": 0.08961215615272522, "2029": 0.18411032855510712, "2048": 0.28597161173820496, "2... | 4418582 | The packaging of the eukaryotic genome in chromatin presents barriers that restrict the access of enzymes that process DNA. To overcome these barriers, cells possess a number of multi-protein, ATP-dependent chromatin remodelling complexes, each containing an ATPase subunit from the SNF2/SWI2 superfamily. Chromatin remo... | A chromatin remodelling complex involved in transcription and DNA processing. |
{"2003": 0.32553088665008545, "2006": 1.0688776969909668, "2007": 0.0019512200960889459, "2019": 0.28670501708984375, "2064": 0.18329764902591705, "2075": 0.5421652793884277, "2079": 0.14349138736724854, "2090": 0.055094651877880096, "2104": 0.11865071207284927, "2109": 0.18248429894447327, "2110": 0.7047978043556213, ... | 4418878 | The development of an oncogenic state is a complex process involving the accumulation of multiple independent mutations that lead to deregulation of cell signalling pathways central to the control of cell growth and cell fate. The ability to define cancer subtypes, recurrence of disease and response to specific therapi... | Oncogenic pathway signatures in human cancers as a guide to targeted therapies |
{"1011": 0.24401791393756866, "1016": 0.2749055027961731, "1019": 0.2689530849456787, "1020": 0.3297532796859741, "1044": 0.7220231294631958, "1045": 0.8525851964950562, "1062": 0.18004031479358673, "2005": 0.11430477350950241, "2006": 0.2089812457561493, "2007": 0.13755162060260773, "2008": 0.07250232994556427, "2011"... | 4421547 | The Insulin-like growth factor 2 (Igf2) and H19 genes are imprinted, resulting in silencing of the maternal and paternal alleles, respectively. This event is dependent upon an imprinted-control region two kilobases upstream of H19 (refs 1, 2). On the paternal chromosome this element is methylated and required for the s... | CTCF mediates methylation-sensitive enhancer-blocking activity at the H19/Igf2 locus. |
{"1011": 0.22392450273036957, "1015": 0.7018978595733643, "1022": 0.41195443272590637, "1043": 0.49030399322509766, "1048": 0.13414156436920166, "1999": 0.0029254043474793434, "2005": 0.011650617234408855, "2025": 0.0019512200960889459, "2028": 0.15442965924739838, "2029": 0.36086538434028625, "2063": 0.770180583000183... | 4421578 | Characterization of human monoclonal antibodies is providing considerable insight into mechanisms of broad HIV-1 neutralization. Here we report an HIV-1 gp41 membrane-proximal external region (MPER)-specific antibody, named 10E8, which neutralizes ∼98% of tested viruses. An analysis of sera from 78 healthy HIV-1-infect... | Broad and potent neutralization of HIV-1 by a gp41-specific human antibody |
{"1018": 0.6482070088386536, "1020": 0.052318159490823746, "1039": 0.18654440343379974, "1052": 0.3283478021621704, "2002": 0.01934296265244484, "2015": 0.0038986403960734606, "2029": 0.08782484382390976, "2058": 0.36967599391937256, "2176": 0.31845372915267944, "2179": 0.13670019805431366, "2182": 0.11430477350950241,... | 4421742 | Emerging evidence suggests that pulmonary iron accumulation is implicated in a spectrum of chronic lung diseases. However, the mechanism(s) involved in pulmonary iron deposition and its role in the in vivo pathogenesis of lung diseases remains unknown. Here we show that a point mutation in the murine ferroportin gene, ... | Disruption of the Hepcidin/Ferroportin Regulatory System Causes Pulmonary Iron Overload and Restrictive Lung Disease |
{"1011": 0.04953393340110779, "1052": 0.3106105625629425, "2004": 0.0029254043474793434, "2011": 0.19862671196460724, "2025": 0.09317722171545029, "2043": 0.14095009863376617, "2064": 0.05786345899105072, "2076": 0.32058215141296387, "2089": 0.1889725625514984, "2100": 0.7258110046386719, "2110": 0.022212404757738113, ... | 4421746 | Polyploidy, increased sets of chromosomes, occurs during development, cellular stress, disease and evolution. Despite its prevalence, little is known about the physiological alterations that accompany polyploidy. We previously described ‘ploidy-specific lethality’, where a gene deletion that is not lethal in haploid or... | Genome-wide genetic analysis of polyploidy in yeast |
{"1011": 0.10379679501056671, "1048": 0.732405424118042, "1998": 0.13157635927200317, "2008": 0.13670019805431366, "2013": 0.34023189544677734, "2014": 0.4673144817352295, "2026": 0.8039615154266357, "2029": 0.31132611632347107, "2035": 0.4574742913246155, "2037": 0.030771657824516296, "2044": 0.18492233753204346, "204... | 4421787 | Haematopoietic stem cells (HSCs) and their subsequent progenitors produce blood cells, but the precise nature and kinetics of this production is a contentious issue. In one model, lymphoid and myeloid production branch after the lymphoid-primed multipotent progenitor (LMPP), with both branches subsequently producing de... | Diverse and heritable lineage imprinting of early haematopoietic progenitors |
{"1054": 0.5313173532485962, "2011": 0.29473719000816345, "2026": 0.5104349255561829, "2041": 0.1905880719423294, "2058": 0.9333322048187256, "2064": 0.22704219818115234, "2071": 0.22782009840011597, "2075": 0.5336109399795532, "2076": 0.43623676896095276, "2078": 0.25239890813827515, "2079": 0.09850110858678818, "2083... | 4422723 | For an epithelium to provide a protective barrier, it must maintain homeostatic cell numbers by matching the number of dividing cells with the number of dying cells. Although compensatory cell division can be triggered by dying cells, it is unknown how cell death might relieve overcrowding due to proliferation. When we... | Crowding induces live cell extrusion to maintain homeostatic cell numbers in epithelia |
{"1011": 0.3106105625629425, "1016": 0.23092569410800934, "1018": 0.0913962796330452, "1045": 0.2317005842924118, "1049": 1.0628231763839722, "1056": 1.2421036958694458, "1999": 0.06795065850019455, "2002": 0.17759032547473907, "2005": 0.026025565341114998, "2006": 0.12642613053321838, "2007": 0.34922540187835693, "201... | 4422734 | The activation of T cells through interaction of their T-cell receptors with antigenic peptide bound to major histocompatibility complex (MHC) on the surface of antigen presenting cells (APCs) is a crucial step in adaptive immunity. Here we use three-dimensional fluorescence microscopy to visualize individual peptide–I... | Direct observation of ligand recognition by T cells |
{"1019": 0.3560888469219208, "1043": 0.3757305145263672, "1048": 0.5139457583427429, "1059": 0.6512666940689087, "2003": 0.11343330889940262, "2011": 0.29109421372413635, "2015": 0.016465263441205025, "2029": 0.07341018319129944, "2043": 0.05139094591140747, "2046": 0.22626367211341858, "2063": 0.8957691192626953, "207... | 4422868 | Intestinal cancer is initiated by Wnt-pathway-activating mutations in genes such as adenomatous polyposis coli (APC). As in most cancers, the cell of origin has remained elusive. In a previously established Lgr5 (leucine-rich-repeat containing G-protein-coupled receptor 5) knockin mouse model, a tamoxifen-inducible Cre... | Crypt stem cells as the cells-of-origin of intestinal cancer |
{"1037": 0.06337817758321762, "1038": 0.18329764902591705, "2000": 0.3070250153541565, "2003": 0.06795065850019455, "2011": 0.36086538434028625, "2013": 0.18004031479358673, "2022": 0.083342544734478, "2028": 0.24018502235412598, "2064": 0.42353010177612305, "2066": 0.004870930220931768, "2070": 0.016465263441205025, "... | 4423203 | Advanced biofuels produced by microorganisms have similar properties to petroleum-based fuels, and can 'drop in' to the existing transportation infrastructure. However, producing these biofuels in yields high enough to be useful requires the engineering of the microorganism's metabolism. Such engineering is not based o... | Microbial engineering for the production of advanced biofuels |
{"1011": 0.06886265426874161, "1021": 0.20739519596099854, "1023": 0.0354953333735466, "1039": 0.32129061222076416, "1051": 0.06977381557226181, "1999": 0.46424978971481323, "2002": 0.10993985831737518, "2003": 0.1221139207482338, "2005": 0.2105647772550583, "2007": 0.0913962796330452, "2010": 0.02412080205976963, "201... | 4423220 | Male infertility is a long-standing enigma of significant medical concern. The integrity of sperm chromatin is a clinical indicator of male fertility and in vitro fertilization potential: chromosome aneuploidy and DNA decondensation or damage are correlated with reproductive failure. Identifying conserved proteins impo... | Sperm chromatin proteomics identifies evolutionarily conserved fertility factors |
{"1011": 0.00875066313892603, "1043": 0.848413348197937, "1050": 0.4734157919883728, "1999": 0.03831886500120163, "2003": 0.40220460295677185, "2005": 0.11951763927936554, "2008": 0.06795065850019455, "2011": 0.2409527748823166, "2024": 0.02316705882549286, "2029": 0.10026945173740387, "2035": 0.05139094591140747, "205... | 4423327 | Nanog is a divergent homeodomain protein found in mammalian pluripotent cells and developing germ cells. Deletion of Nanog causes early embryonic lethality, whereas constitutive expression enables autonomous self-renewal of embryonic stem cells. Nanog is accordingly considered a core element of the pluripotent transcri... | Nanog safeguards pluripotency and mediates germline development |
{"1011": 0.10467668622732162, "1015": 0.19541899859905243, "1043": 0.5860490798950195, "1044": 0.2711893916130066, "1155": 0.5495203733444214, "1157": 0.23787821829319, "1999": 0.0842406153678894, "2004": 0.08961215615272522, "2007": 0.0770333781838417, "2008": 0.052318159490823746, "2011": 0.5156965255737305, "2019": ... | 4423401 | Macrophages activated by the Gram-negative bacterial product lipopolysaccharide switch their core metabolism from oxidative phosphorylation to glycolysis. Here we show that inhibition of glycolysis with 2-deoxyglucose suppresses lipopolysaccharide-induced interleukin-1β but not tumour-necrosis factor-α in mouse macroph... | Succinate is an inflammatory signal that induces IL-1β through HIF-1α |
{"1050": 0.29473719000816345, "1059": 0.5393219590187073, "2011": 0.07793712615966797, "2012": 0.1619328260421753, "2029": 0.12384103983640671, "2036": 0.5104349255561829, "2043": 0.014542185701429844, "2046": 0.4002431631088257, "2063": 0.45994341373443604, "2066": 0.2409527748823166, "2076": 0.6128603219985962, "2094... | 4423559 | Environmental and genetic aberrations lead to neural tube closure defects (NTDs) in 1 out of every 1,000 births. Mouse and frog models for these birth defects have indicated that Van Gogh-like 2 (Vangl2, also known as Strabismus) and other components of planar cell polarity (PCP) signalling might control neurulation by... | Planar cell polarity signalling couples cell division and morphogenesis during neurulation |
{"1038": 0.021256839856505394, "1049": 0.5450005531311035, "2000": 0.21922965347766876, "2001": 0.006812678650021553, "2003": 0.11865071207284927, "2005": 0.00875066313892603, "2026": 0.9084475636482239, "2033": 0.129004567861557, "2045": 0.0797421783208847, "2047": 0.6218147873878479, "2052": 0.0354953333735466, "2054... | 4424888 | Tuberculosis (TB) is more prevalent in the world today than at any other time in human history. Mycobacterium tuberculosis, the pathogen responsible for TB, uses diverse strategies to survive in a variety of host lesions and to evade immune surveillance. A key question is how robust are our approaches to discovering ne... | The challenge of new drug discovery for tuberculosis |
{"1011": 0.02792670577764511, "1040": 0.3615458607673645, "1043": 0.8161250352859497, "1050": 0.2034190446138382, "1060": 0.3304552733898163, "1999": 0.10906458646059036, "2004": 0.4709797203540802, "2005": 0.3554046154022217, "2011": 0.43244171142578125, "2012": 0.7352184057235718, "2029": 0.056018441915512085, "2035"... | 4425507 | Since it was discovered that the anti-hypertensive agent ifenprodil has neuroprotective activity through its effects on NMDA (N-methyl-D-aspartate) receptors, a determined effort has been made to understand the mechanism of action and to develop improved therapeutic compounds on the basis of this knowledge. Neurotransm... | Subunit Arrangement and Phenylethanolamine Binding in GluN1/GluN2B NMDA Receptors |
{"1005": 0.11081436276435852, "1011": 0.21687394380569458, "1016": 0.31560876965522766, "1039": 0.28670501708984375, "1044": 0.07068414986133575, "1050": 0.7463917136192322, "1055": 0.4624064862728119, "1998": 0.371698260307312, "2002": 0.11430477350950241, "2003": 0.06246116757392883, "2011": 0.3269403576850891, "2015... | 4427060 | Crohn's disease and ulcerative colitis, the two main types of chronic inflammatory bowel disease, are multifactorial conditions of unknown aetiology. A susceptibility locus for Crohn's disease has been mapped to chromosome 16. Here we have used a positional-cloning strategy, based on linkage analysis followed by linkag... | Association of NOD2 leucine-rich repeat variants with susceptibility to Crohn's disease. |
{"1006": 0.1011524572968483, "1009": 0.35403475165367126, "1011": 0.27564704418182373, "1013": 0.053244512528181076, "1017": 0.4177590310573578, "1018": 0.034552380442619324, "1038": 0.4374985992908478, "1039": 0.8567397594451904, "1040": 0.57457035779953, "1042": 0.5174443125724792, "1047": 0.9864287376403809, "1996":... | 4427392 | The functional heart is comprised of distinct mesoderm-derived lineages including cardiomyocytes, endothelial cells and vascular smooth muscle cells. Studies in the mouse embryo and the mouse embryonic stem cell differentiation model have provided evidence indicating that these three lineages develop from a common Flk-... | Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population |
{"1055": 0.026025565341114998, "1997": 0.13414156436920166, "1998": 0.02887592278420925, "1999": 0.0009760859538801014, "2006": 0.8517522215843201, "2019": 0.21372433006763458, "2054": 0.21922965347766876, "2060": 0.3339579105377197, "2070": 0.2160874605178833, "2071": 0.2317005842924118, "2075": 0.6064908504486084, "2... | 4429118 | The mediators and cellular effectors of inflammation are important constituents of the local environment of tumours. In some types of cancer, inflammatory conditions are present before a malignant change occurs. Conversely, in other types of cancer, an oncogenic change induces an inflammatory microenvironment that prom... | Cancer-related inflammation |
{"1011": 0.04953393340110779, "1017": 0.1229778528213501, "1018": 0.3141832649707794, "1041": 0.2800849378108978, "1056": 0.8039615154266357, "1996": 0.12728634476661682, "2002": 0.33115679025650024, "2003": 0.06246116757392883, "2005": 0.2954642176628113, "2007": 0.04674193635582924, "2008": 0.06977381557226181, "2011... | 4429388 | The ESCRT (endosomal sorting complex required for transport) pathway is required for terminal membrane fission events in several important biological processes, including endosomal intraluminal vesicle formation, HIV budding and cytokinesis. VPS4 ATPases perform a key function in this pathway by recognizing membrane-as... | ESCRT-III recognition by VPS4 ATPases |
{"1011": 0.39696553349494934, "1015": 0.6286086440086365, "1042": 0.22704219818115234, "1043": 0.7239188551902771, "1044": 0.17840765416622162, "1052": 0.7454653382301331, "1996": 0.2837681770324707, "2002": 1.0087559223175049, "2003": 0.2763880789279938, "2008": 0.16442140936851501, "2011": 0.10555581003427505, "2013"... | 4429668 | The Saccharomyces cerevisiae Pif1 helicase is the prototypical member of the Pif1 DNA helicase family, which is conserved from bacteria to humans. Here we show that exceptionally potent G-quadruplex unwinding is conserved among Pif1 helicases. Moreover, Pif1 helicases from organisms separated by more than 3 billion yea... | Pif1 family helicases suppress genome instability at G-quadruplex motifs |
{"1011": 0.07159364968538284, "1044": 0.4356052577495575, "1048": 0.5562619566917419, "1051": 0.09228714555501938, "1060": 0.10026945173740387, "2003": 0.21135559678077698, "2005": 0.08692999184131622, "2011": 0.19541899859905243, "2030": 0.06795065850019455, "2033": 0.7134475708007812, "2083": 0.015504186972975731, "2... | 4429932 | Metastasis is a multistep process responsible for most cancer deaths, and it can be influenced by both the immediate microenvironment (cell–cell or cell–matrix interactions) and the extended tumour microenvironment (for example vascularization). Hypoxia (low oxygen) is clinically associated with metastasis and poor pat... | Lysyl oxidase is essential for hypoxia-induced metastasis |
{"1009": 0.6425731778144836, "1011": 0.15777134895324707, "1017": 0.151916041970253, "1039": 0.7500885725021362, "1060": 0.20580662786960602, "1999": 0.01934296265244484, "2004": 0.10467668622732162, "2005": 0.04767346754670143, "2008": 0.04394211992621422, "2011": 0.26146242022514343, "2013": 0.23479416966438293, "202... | 4430962 | The cancer stem cell (CSC) hypothesis suggests that neoplastic clones are maintained exclusively by a rare fraction of cells with stem cell properties. Although the existence of CSCs in human leukaemia is established, little evidence exists for CSCs in solid tumours, except for breast cancer. Recently, we prospectively... | Identification of human brain tumour initiating cells |
{"1038": 0.8805016279220581, "1050": 0.17267228662967682, "1061": 0.053244512528181076, "2000": 0.026025565341114998, "2004": 0.15275461971759796, "2005": 0.175953671336174, "2012": 0.10818854719400406, "2015": 0.020300358533859253, "2022": 0.1685553640127182, "2040": 0.8949713706970215, "2043": 0.034552380442619324, "... | 4432763 | The World Health Organization (WHO) convened an Expert Committee to reevaluate the use of anthropometry at different ages for assessing health, nutrition, and social wellbeing. The Committee's task included identifying reference data for anthropometric indexes when appropriate, and providing guidelines on how the data ... | Anthropometric reference data for international use: recommendations from a World Health Organization Expert Committee. |
{"1013": 0.021256839856505394, "1040": 0.32129061222076416, "1044": 0.19782574474811554, "2002": 0.05046287178993225, "2010": 0.7380234599113464, "2033": 0.14939609169960022, "2061": 0.0752234235405922, "2064": 0.2622140049934387, "2071": 0.04487626627087593, "2075": 0.11081436276435852, "2080": 0.2786078155040741, "21... | 4434951 | BACKGROUND Age-associated epigenetic changes are implicated in aging. Notably, age-associated DNA methylation changes comprise a so-called aging "clock", a robust biomarker of aging. However, while genetic, dietary and drug interventions can extend lifespan, their impact on the epigenome is uncharacterised. To fill thi... | Diverse interventions that extend mouse lifespan suppress shared age-associated epigenetic changes at critical gene regulatory regions |
{"1041": 0.5461324453353882, "1051": 0.03925827145576477, "1058": 0.18329764902591705, "2003": 0.15526613593101501, "2004": 0.14518201351165771, "2015": 0.9531047344207764, "2024": 0.32905077934265137, "2054": 0.2105647772550583, "2079": 0.11430477350950241, "2089": 0.04860413447022438, "2109": 0.4770587682723999, "213... | 4435369 | Extracellular vesicles (EVs) are cell-derived membrane vesicles, and represent an endogenous mechanism for intercellular communication. Since the discovery that EVs are capable of functionally transferring biological information, the potential use of EVs as drug delivery vehicles has gained considerable scientific inte... | Extracellular vesicles for drug delivery. |
{"1014": 0.4158279001712799, "1038": 0.6400018334388733, "1039": 0.4067663550376892, "1040": 0.03266380727291107, "1042": 0.018384648486971855, "1050": 0.4400174915790558, "1052": 0.38041436672210693, "1054": 0.6522845029830933, "1061": 0.4974553883075714, "2005": 0.056018441915512085, "2007": 0.10993985831737518, "201... | 4442799 | BACKGROUND Soy protein or its components may protect against the atherosclerotic cardiovascular disease (CVD) risk factors total homocysteine (tHcy), C-reactive protein (CRP), and excess body iron, which generally increase with menopause. OBJECTIVE The primary objective of this study was to determine the independent ef... | Effects of soy isoflavones and phytate on homocysteine, C-reactive protein, and iron status in postmenopausal women. |
{"1011": 0.016465263441205025, "1013": 0.2539152204990387, "1015": 0.11778303235769272, "1016": 0.4770587682723999, "1017": 0.17267228662967682, "1018": 0.5255602598190308, "2011": 0.3547199070453644, "2025": 0.010684899985790253, "2029": 0.2674594223499298, "2048": 0.28670501708984375, "2063": 0.2539152204990387, "207... | 4444861 | Cells deficient in the Brca1 and Brca2 genes have reduced capacity to repair DNA double-strand breaks by homologous recombination and consequently are hypersensitive to DNA-damaging agents, including cisplatin and poly(ADP-ribose) polymerase (PARP) inhibitors. Here we show that loss of the MLL3/4 complex protein, PTIP,... | Replication Fork Stability Confers Chemoresistance in BRCA-deficient Cells |
{"1014": 0.3683255612850189, "1038": 0.10906458646059036, "1039": 0.08513788133859634, "1041": 0.6603899002075195, "1043": 0.27044451236724854, "1048": 0.4067663550376892, "1050": 0.13243216276168823, "1052": 0.32058215141296387, "1055": 0.3554046154022217, "2007": 0.012615402229130268, "2090": 0.15777134895324707, "20... | 4445629 | OBJECTIVES The aim of this study was to determine the prognostic value of plasma corin in patients with chronic heart failure (CHF). BACKGROUND In recent years, accumulating evidence has indicated that corin plays a critical role in regulating blood pressure and cardiac function. METHODS We enrolled 1,148 consecutive C... | Plasma Corin as a Predictor of Cardiovascular Events in Patients With Chronic Heart Failure. |
{"1011": 0.5168620347976685, "1055": 0.2659635543823242, "1156": 0.7389566898345947, "1996": 0.07431721687316895, "1997": 0.0606246218085289, "2002": 0.8264343738555908, "2003": 0.21530038118362427, "2011": 0.02316705882549286, "2024": 0.12814582884311676, "2029": 0.12642613053321838, "2045": 0.43244171142578125, "2048... | 4446814 | Alzheimer's disease is the most common neurodegenerative disease, and there are no mechanism-based therapies. The disease is defined by the presence of abundant neurofibrillary lesions and neuritic plaques in the cerebral cortex. Neurofibrillary lesions comprise paired helical and straight tau filaments, whereas tau fi... | Cryo-EM structures of Tau filaments from Alzheimer’s disease brain |
{"1011": 0.053244512528181076, "1039": 0.26146242022514343, "1040": 0.16359257698059082, "1043": 0.6144463419914246, "1048": 0.04860413447022438, "1052": 0.19782574474811554, "1173": 0.1946154683828354, "2005": 0.04207121208310127, "2008": 0.006812678650021553, "2011": 0.46608972549438477, "2015": 0.23556606471538544, ... | 4447055 | Contusive spinal cord injury leads to a variety of disabilities owing to limited neuronal regeneration and functional plasticity. It is well established that an upregulation of glial-derived chondroitin sulphate proteoglycans (CSPGs) within the glial scar and perineuronal net creates a barrier to axonal regrowth and sp... | Modulation of the proteoglycan receptor PTPσ promotes recovery after spinal cord injury |
{"1011": 0.0038986403960734606, "1020": 0.6265231370925903, "1043": 0.1212492436170578, "1061": 0.2561853528022766, "2008": 0.14433705806732178, "2029": 0.25845035910606384, "2076": 0.10379679501056671, "2078": 0.20501139760017395, "2079": 0.3757305145263672, "2083": 0.18573370575904846, "2128": 0.29109421372413635, "2... | 4447785 | Inflammation promotes regeneration of injured tissues through poorly understood mechanisms, some of which involve interleukin (IL)-6 family members, the expression of which is elevated in many diseases including inflammatory bowel diseases and colorectal cancer. Here we show in mice and human cells that gp130, a co-rec... | A gp130–Src–YAP module links inflammation to epithelial regeneration |
{"1013": 0.10555581003427505, "1014": 0.6149744987487793, "1019": 0.39367714524269104, "1039": 0.19862671196460724, "1043": 0.42926809191703796, "1044": 0.9613537192344666, "1052": 0.2976420819759369, "1055": 0.3824150264263153, "1997": 0.06154331564903259, "1999": 0.2696990668773651, "2001": 0.04674193635582924, "2002... | 4449524 | The concentration of hemoglobin in blacks was found to be 0.5 to 1.0 g/dl lower than that of income-matched whites in several large surveys. This difference could be a racial characteristic of blacks, or it might be due to a higher frequency of genetic traits such as thalassemia minor and hemoglobinopathies, or to envi... | Hemoglobin concentration in white, black, and Oriental children: is there a need for separate criteria in screening for anemia? |
{"1017": 0.21922965347766876, "1052": 0.14686977863311768, "2003": 0.1946154683828354, "2011": 0.0038986403960734606, "2029": 0.05139094591140747, "2033": 0.5370414853096008, "2035": 0.06429435312747955, "2054": 0.013579257763922215, "2061": 0.9131608605384827, "2064": 0.2493593990802765, "2083": 0.24631060659885406, "... | 4452318 | Pluripotency is defined by the ability of a cell to differentiate to the derivatives of all the three embryonic germ layers: ectoderm, mesoderm and endoderm. Pluripotent cells can be captured via the archetypal derivation of embryonic stem cells or via somatic cell reprogramming. Somatic cells are induced to acquire a ... | Divergent reprogramming routes lead to alternative stem-cell states |
{"1017": 0.0606246218085289, "1038": 0.319873183965683, "1048": 0.34508460760116577, "2003": 0.36358460783958435, "2006": 0.2089812457561493, "2011": 0.3560888469219208, "2012": 0.619189441204071, "2075": 0.053244512528181076, "2076": 0.33325836062431335, "2079": 0.23247487843036652, "2091": 0.010684899985790253, "2135... | 4452659 | Macroautophagy (hereafter referred to as autophagy) is a catabolic membrane trafficking process that degrades a variety of cellular constituents and is associated with human diseases. Although extensive studies have focused on autophagic turnover of cytoplasmic materials, little is known about the role of autophagy in ... | Autophagy mediates degradation of nuclear lamina |
{"1011": 0.2689530849456787, "1017": 0.0174254160374403, "1052": 0.14179791510105133, "1997": 0.03925827145576477, "1999": 0.10993985831737518, "2003": 0.17431432008743286, "2005": 0.09406650811433792, "2007": 0.03925827145576477, "2008": 0.1685553640127182, "2024": 0.38441169261932373, "2029": 0.28890204429626465, "20... | 4454788 | Advances in our understanding of the mechanisms that bring about the resolution of acute inflammation have uncovered a new genus of pro-resolving lipid mediators that include the lipoxin, resolvin, protectin and maresin families, collectively called specialized pro-resolving mediators. Synthetic versions of these media... | Pro-resolving lipid mediators are leads for resolution physiology |
{"1011": 0.27564704418182373, "1016": 0.045809537172317505, "1017": 0.49982786178588867, "1044": 0.6086184978485107, "1047": 0.08692999184131622, "1048": 0.29981520771980286, "1051": 0.20660123229026794, "1052": 0.4879087805747986, "1062": 1.0326838493347168, "1999": 0.09406650811433792, "2004": 0.009718249551951885, "... | 4455466 | Recognition of modified histones by ‘reader’ proteins plays a critical role in the regulation of chromatin. H3K36 trimethylation (H3K36me3) is deposited onto the nucleosomes in the transcribed regions after RNA polymerase II elongation. In yeast, this mark in turn recruits epigenetic regulators to reset the chromatin t... | ZMYND11 links histone H3.3K36me3 to transcription elongation and tumour suppression |
{"1011": 0.01934296265244484, "1038": 0.8699195384979248, "1040": 0.10467668622732162, "1043": 0.2719337046146393, "1047": 0.06703783571720123, "2004": 0.46853771805763245, "2005": 0.27044451236724854, "2008": 0.036437395960092545, "2029": 0.27342069149017334, "2043": 0.1401015669107437, "2049": 0.11865071207284927, "2... | 4456756 | Brain-derived neurotrophic factor (BDNF) and its receptor TrkB are crucial for many forms of neuronal plasticity, including structural long-term potentiation (sLTP), which is a correlate of an animal’s learning. However, it is unknown whether BDNF release and TrkB activation occur during sLTP, and if so, when and where... | Autocrine BDNF–TrkB signalling within a single dendritic spine |
{"1017": 0.25239890813827515, "1020": 0.17922431230545044, "1040": 0.06977381557226181, "1042": 0.5618454217910767, "1047": 0.6649205088615417, "1052": 0.151916041970253, "1056": 0.4518963396549225, "2006": 0.4914994537830353, "2007": 0.009718249551951885, "2015": 0.3615458607673645, "2029": 0.05046287178993225, "2046"... | 4457160 | Pancreatic cancer remains one of the most lethal of malignancies and a major health burden. We performed whole-genome sequencing and copy number variation (CNV) analysis of 100 pancreatic ductal adenocarcinomas (PDACs). Chromosomal rearrangements leading to gene disruption were prevalent, affecting genes known to be im... | Whole genomes redefine the mutational landscape of pancreatic cancer |
{"1015": 0.25995752215385437, "1016": 0.04953393340110779, "1051": 1.001607894897461, "2000": 0.1619328260421753, "2005": 0.20739519596099854, "2010": 0.7934166193008423, "2011": 0.19541899859905243, "2013": 0.48068851232528687, "2029": 0.11430477350950241, "2034": 0.2247048318386078, "2046": 0.5186077356338501, "2061"... | 4457834 | The transfer of somatic cell nuclei into oocytes can give rise to pluripotent stem cells that are consistently equivalent to embryonic stem cells, holding promise for autologous cell replacement therapy. Although methods to induce pluripotent stem cells from somatic cells by transcription factors are widely used in bas... | Human oocytes reprogram adult somatic nuclei of a type 1 diabetic to diploid pluripotent stem cells |
{"1011": 0.2763880789279938, "1017": 0.22937409579753876, "1042": 0.2105647772550583, "1043": 0.3683255612850189, "1055": 0.18004031479358673, "1155": 0.0913962796330452, "1156": 1.1115491390228271, "1157": 0.4462870955467224, "1998": 0.09672962874174118, "2003": 0.16359257698059082, "2004": 0.05694137513637543, "2011"... | 4459491 | Alzheimer’s disease is the most common form of dementia, characterized by two pathological hallmarks: amyloid-β plaques and neurofibrillary tangles. The amyloid hypothesis of Alzheimer’s disease posits that the excessive accumulation of amyloid-β peptide leads to neurofibrillary tangles composed of aggregated hyperphos... | A three-dimensional human neural cell culture model of Alzheimer’s disease |
{"1011": 0.1384023278951645, "1041": 0.24325250089168549, "1052": 0.6070231795310974, "2000": 0.32553088665008545, "2011": 0.24018502235412598, "2029": 0.055094651877880096, "2033": 0.8374842405319214, "2044": 0.684319257736206, "2064": 0.34715715050697327, "2066": 0.3923587501049042, "2076": 0.13670019805431366, "2079... | 4460880 | Endothelial cells contribute to a subset of cardiac fibroblasts by undergoing endothelial-to-mesenchymal transition, but whether cardiac fibroblasts can adopt an endothelial cell fate and directly contribute to neovascularization after cardiac injury is not known. Here, using genetic fate map techniques, we demonstrate... | Mesenchymal-endothelial-transition contributes to cardiac neovascularization |
{"1013": 0.14095009863376617, "1038": 0.6149744987487793, "1040": 1.3387973308563232, "1045": 0.6389714479446411, "1048": 0.4286321699619293, "1999": 0.0797421783208847, "2005": 0.25845035910606384, "2012": 0.24325250089168549, "2022": 0.3464667797088623, "2035": 0.2317005842924118, "2085": 0.012615402229130268, "2087"... | 4462079 | Recent evidence suggests that vitamin D intakes above current recommendations may be associated with better health outcomes. However, optimal serum concentrations of 25-hydroxyvitamin D [25(OH)D] have not been defined. This review summarizes evidence from studies that evaluated thresholds for serum 25(OH)D concentratio... | Estimation of optimal serum concentrations of 25-hydroxyvitamin D for multiple health outcomes. |
{"1011": 0.151916041970253, "1017": 0.2145126610994339, "1039": 0.5584990978240967, "1043": 0.6112717390060425, "1997": 0.07159364968538284, "2005": 0.04487626627087593, "2006": 0.011650617234408855, "2011": 0.16690383851528168, "2012": 0.3601844012737274, "2015": 0.14518201351165771, "2029": 0.05694137513637543, "2046... | 4462139 | Eukaryotic genomes are folded into three-dimensional structures, such as self-associating topological domains, the borders of which are enriched in cohesin and CCCTC-binding factor (CTCF) required for long-range interactions. How local chromatin interactions govern higher-order folding of chromatin fibres and the funct... | Cohesin-dependent globules and heterochromatin shape 3D genome architecture in S. pombe |
{"1042": 0.1930064558982849, "1052": 0.1619328260421753, "1056": 0.013579257763922215, "1996": 0.37907835841178894, "2005": 0.07793712615966797, "2012": 0.37304413318634033, "2029": 0.1477125883102417, "2037": 0.0029254043474793434, "2043": 0.28597161173820496, "2044": 0.7105726003646851, "2046": 0.12038381397724152, "... | 4462155 | Fear memories allow animals to avoid danger, thereby increasing their chances of survival. Fear memories can be retrieved long after learning, but little is known about how retrieval circuits change with time. Here we show that the dorsal midline thalamus of rats is required for the retrieval of auditory conditioned fe... | A temporal shift in the circuits mediating retrieval of fear memory |
{"1017": 0.10291612148284912, "1041": 0.3554046154022217, "1044": 0.23402166366577148, "1060": 0.5139457583427429, "2003": 0.03831886500120163, "2011": 0.10467668622732162, "2013": 0.32553088665008545, "2015": 0.5596157908439636, "2024": 0.28597161173820496, "2029": 0.02316705882549286, "2036": 0.2822965085506439, "204... | 4462419 | Mouse embryonic stem (ES) cells are isolated from the inner cell mass of blastocysts, and can be preserved in vitro in a naive inner-cell-mass-like configuration by providing exogenous stimulation with leukaemia inhibitory factor (LIF) and small molecule inhibition of ERK1/ERK2 and GSK3β signalling (termed 2i/LIF condi... | Derivation of novel human ground state naive pluripotent stem cells |
{"1011": 0.37304413318634033, "1015": 0.09938567131757736, "1045": 0.5483922958374023, "1048": 0.3106105625629425, "1049": 0.9769153594970703, "1056": 0.8780695199966431, "1999": 0.255429208278656, "2002": 0.06429435312747955, "2004": 0.2786078155040741, "2010": 0.7827593088150024, "2011": 0.1384023278951645, "2015": 0... | 4462777 | Human tumours typically harbour a remarkable number of somatic mutations. If presented on major histocompatibility complex class I molecules (MHCI), peptides containing these mutations could potentially be immunogenic as they should be recognized as ‘non-self’ neo-antigens by the adaptive immune system. Recent work has... | Predicting immunogenic tumour mutations by combining mass spectrometry and exome sequencing |
{"1011": 0.18004031479358673, "1023": 0.8691008687019348, "1052": 0.5466978549957275, "2003": 0.11691460013389587, "2005": 0.22001366317272186, "2008": 0.030771657824516296, "2011": 0.010684899985790253, "2013": 0.5045560002326965, "2029": 0.1751343309879303, "2030": 0.2830325961112976, "2038": 0.05694137513637543, "20... | 4462919 | The RNA-guided endonuclease Cas9 has emerged as a versatile genome-editing platform. However, the size of the commonly used Cas9 from Streptococcus pyogenes (SpCas9) limits its utility for basic research and therapeutic applications that use the highly versatile adeno-associated virus (AAV) delivery vehicle. Here, we c... | In vivo genome editing using Staphylococcus aureus Cas9 |
{"1003": 0.19622190296649933, "1009": 0.3949938118457794, "1013": 0.11081436276435852, "1014": 0.31560876965522766, "1040": 0.2689530849456787, "1047": 0.6950984001159668, "1048": 0.8074519634246826, "1052": 0.2659635543823242, "1059": 0.5860490798950195, "1060": 0.5080875158309937, "1061": 0.2160874605178833, "1997": ... | 4463588 | BACKGROUND Little is known about how the intensity of exercise influences cardiovascular fitness and body composition, especially in obese adolescents. OBJECTIVE Our goal was to determine the effects of physical training intensity on the cardiovascular fitness, percentage of body fat (%BF), and visceral adipose tissue ... | Effects of exercise intensity on cardiovascular fitness, total body composition, and visceral adiposity of obese adolescents. |
{"1003": 0.29619070887565613, "1011": 0.0038986403960734606, "1014": 0.40351006388664246, "1048": 0.6833335757255554, "1999": 0.06429435312747955, "2001": 0.012615402229130268, "2003": 0.1401015669107437, "2005": 0.040196798741817474, "2025": 0.08064348995685577, "2086": 0.055094651877880096, "2092": 0.2478361576795578... | 4463811 | Dietary energy restriction has been a widely used means of experimentally extending mammalian life span. We report here that lifelong reduction in the concentration of a single dietary component, the essential amino acid L-methionine, from 0.86 to 0.17% of the diet results in a 30% longer life span of male Fischer 344 ... | Low methionine ingestion by rats extends life span. |
{"1011": 0.02316705882549286, "1015": 0.03360854089260101, "1038": 0.39762192964553833, "1039": 0.38041436672210693, "1041": 0.5051454305648804, "1060": 0.6038249135017395, "1999": 0.1221139207482338, "2005": 0.08782484382390976, "2007": 0.28450319170951843, "2011": 0.18492233753204346, "2012": 0.151916041970253, "2020... | 4464565 | We performed a functional genomic analysis to study the effect of epicatechin and polyphenolic cocoa extract in the human colon adenocarcinoma cell line Caco-2. The specific Human Hematology/Immunology cDNA arrays by Clontech, containing 406 genes in duplicate, were used. The differentially expressed genes were classif... | Epicatechin and a cocoa polyphenolic extract modulate gene expression in human Caco-2 cells. |
{"1011": 0.13243216276168823, "1019": 0.4067663550376892, "1042": 0.2231435477733612, "2003": 0.12384103983640671, "2007": 0.31132611632347107, "2015": 0.1693800985813141, "2024": 0.043007105588912964, "2029": 0.129004567861557, "2037": 0.1011524572968483, "2054": 0.034552380442619324, "2057": 0.34370049834251404, "207... | 4465608 | Enhancers control the correct temporal and cell-type-specific activation of gene expression in multicellular eukaryotes. Knowing their properties, regulatory activity and targets is crucial to understand the regulation of differentiation and homeostasis. Here we use the FANTOM5 panel of samples, covering the majority o... | An atlas of active enhancers across human cell types and tissues |
{"1012": 0.05139094591140747, "1021": 0.47584590315818787, "1039": 0.8332487344741821, "1040": 0.5116065740585327, "2003": 0.012615402229130268, "2004": 0.03831886500120163, "2005": 0.00875066313892603, "2007": 0.12814582884311676, "2011": 0.19541899859905243, "2015": 0.11691460013389587, "2037": 0.013579257763922215, ... | 4465735 | The gastrointestinal tracts of mammals are colonized by hundreds of microbial species that contribute to health, including colonization resistance against intestinal pathogens. Many antibiotics destroy intestinal microbial communities and increase susceptibility to intestinal pathogens. Among these, Clostridium diffici... | Precision microbiome reconstitution restores bile acid mediated resistance to Clostridium difficile |
{"1011": 0.26146242022514343, "1016": 0.4437839686870575, "1041": 0.036437395960092545, "1056": 0.8731874823570251, "1996": 0.1358480453491211, "1997": 0.056018441915512085, "2007": 0.0038986403960734606, "2011": 0.35403475165367126, "2012": 0.17759032547473907, "2029": 0.23787821829319, "2034": 0.272677481174469, "204... | 4465762 | Transcription of eukaryotic protein-coding genes begins with assembly of the RNA polymerase (Pol) II initiation complex and promoter DNA opening. Here we report cryo-electron microscopy (cryo-EM) structures of yeast initiation complexes containing closed and open DNA at resolutions of 8.8 Å and 3.6 Å, respectively. DNA... | Transcription initiation complex structures elucidate DNA opening |
{"1011": 0.32129061222076416, "1021": 0.6828403472900391, "1039": 0.12728634476661682, "1999": 0.0752234235405922, "2005": 0.056018441915512085, "2008": 0.02316705882549286, "2010": 0.19782574474811554, "2011": 0.20102575421333313, "2026": 1.2759300470352173, "2029": 0.26446542143821716, "2033": 0.16359257698059082, "2... | 4467129 | Poor prognosis in neuroblastoma is associated with genetic amplification of MYCN. MYCN is itself a target of let-7, a tumour suppressor family of microRNAs implicated in numerous cancers. LIN28B, an inhibitor of let-7 biogenesis, is overexpressed in neuroblastoma and has been reported to regulate MYCN. Here we show, ho... | Multiple mechanisms disrupt the let-7 microRNA family in neuroblastoma |
{"1011": 0.3269403576850891, "1015": 0.020300358533859253, "1018": 0.3601844012737274, "1022": 0.3656192123889923, "1048": 0.6931471824645996, "1056": 0.9493325352668762, "2005": 0.0354953333735466, "2007": 0.1946154683828354, "2029": 0.2026219218969345, "2060": 0.021256839856505394, "2090": 0.05046287178993225, "2099"... | 4468861 | Immune checkpoint inhibitors result in impressive clinical responses, but optimal results will require combination with each other and other therapies. This raises fundamental questions about mechanisms of non-redundancy and resistance. Here we report major tumour regressions in a subset of patients with metastatic mel... | Radiation and Dual Checkpoint Blockade Activates Non-Redundant Immune Mechanisms in Cancer |
{"1011": 0.15526613593101501, "1018": 0.3084607720375061, "1021": 0.2034190446138382, "1043": 0.6149744987487793, "1044": 0.13925230503082275, "1047": 0.06429435312747955, "1155": 0.7408206462860107, "2007": 0.10818854719400406, "2008": 0.11517547070980072, "2011": 0.4556184411048889, "2015": 0.17267228662967682, "2019... | 4469125 | The regulated release of anorexigenic α-melanocyte stimulating hormone (α-MSH) and orexigenic Agouti-related protein (AgRP) from discrete hypothalamic arcuate neurons onto common target sites in the central nervous system has a fundamental role in the regulation of energy homeostasis. Both peptides bind with high affin... | G-protein-independent coupling of MC4R to Kir7.1 in hypothalamic neurons |
{"1009": 0.25088030099868774, "1011": 0.23633737862110138, "1043": 0.987156867980957, "1044": 0.15610189735889435, "1054": 0.6022219061851501, "2003": 0.1718502640724182, "2007": 0.12728634476661682, "2011": 0.1212492436170578, "2025": 0.0797421783208847, "2029": 0.22937409579753876, "2038": 0.06429435312747955, "2075"... | 4474874 | BACKGROUND & AIMS Ghrelin is an orexigenic peptide with gastroprokinetic effects. Mice with streptozotocin (STZ)-induced diabetes exhibit hyperphagia, altered gastric emptying, and increased plasma ghrelin levels. We investigated the causative role of ghrelin herein by comparing changes in ghrelin receptor knockout (gr... | Role of ghrelin in the relationship between hyperphagia and accelerated gastric emptying in diabetic mice. |
{"1013": 0.26296505331993103, "1014": 0.08782484382390976, "1040": 0.7258110046386719, "1043": 0.37371641397476196, "1044": 0.04860413447022438, "1045": 0.39762192964553833, "1048": 0.21687394380569458, "1059": 0.0009760859538801014, "1997": 0.07250232994556427, "1999": 0.18978065252304077, "2000": 0.2034190446138382, ... | 4483571 | BACKGROUND The cholecalciferol inputs required to achieve or maintain any given serum 25-hydroxycholecalciferol concentration are not known, particularly within ranges comparable to the probable physiologic supply of the vitamin. OBJECTIVES The objectives were to establish the quantitative relation between steady state... | Human serum 25-hydroxycholecalciferol response to extended oral dosing with cholecalciferol. |
{"1011": 0.22001366317272186, "1045": 0.08603433519601822, "1047": 0.6027565002441406, "1055": 0.27342069149017334, "1999": 0.151916041970253, "2028": 0.10731173306703568, "2029": 0.018384648486971855, "2035": 0.15860503911972046, "2061": 0.4462870955467224, "2064": 0.06977381557226181, "2075": 0.0317181795835495, "208... | 4489217 | BACKGROUND Intratumor heterogeneity may foster tumor evolution and adaptation and hinder personalized-medicine strategies that depend on results from single tumor-biopsy samples. METHODS To examine intratumor heterogeneity, we performed exome sequencing, chromosome aberration analysis, and ploidy profiling on multiple ... | Intratumor heterogeneity and branched evolution revealed by multiregion sequencing. |
{"1060": 0.6317287683486938, "1061": 0.20818853378295898, "1997": 0.11951763927936554, "1999": 0.058784693479537964, "2001": 0.13157635927200317, "2011": 0.15777134895324707, "2013": 0.09584271162748337, "2020": 0.2539152204990387, "2038": 0.09228714555501938, "2042": 0.29400965571403503, "2058": 0.3750596046447754, "2... | 4492358 | The colonization process of the infant gut microbiome has been called chaotic, but this view could reflect insufficient documentation of the factors affecting the microbiome. We performed a 2.5-y case study of the assembly of the human infant gut microbiome, to relate life events to microbiome composition and function.... | Succession of microbial consortia in the developing infant gut microbiome. |
{"1011": 0.4145384132862091, "1020": 0.06246116757392883, "1021": 0.0009760859538801014, "1022": 0.18816383183002472, "1038": 0.037378571927547455, "1041": 0.9591107368469238, "1043": 0.7370892763137817, "1056": 0.10818854719400406, "1157": 0.6573580503463745, "1997": 0.1510767638683319, "1999": 0.3923587501049042, "20... | 4500832 | gamma-tocopherol is the major form of vitamin E in many plant seeds and in the US diet, but has drawn little attention compared with alpha-tocopherol, the predominant form of vitamin E in tissues and the primary form in supplements. However, recent studies indicate that gamma-tocopherol may be important to human health... | gamma-tocopherol, the major form of vitamin E in the US diet, deserves more attention. |
{"1011": 0.2470736801624298, "1014": 0.5528968572616577, "1018": 0.22001366317272186, "1019": 0.18978065252304077, "1020": 0.151916041970253, "1022": 0.22392450273036957, "1041": 0.8400169610977173, "1052": 0.5278670787811279, "1055": 0.11604541540145874, "1159": 0.3248254358768463, "2004": 0.4437839686870575, "2007": ... | 4505748 | BACKGROUND The apolipoprotein E (APOE) genotype provides information on the risk of Alzheimer's disease, but the genotyping of patients and their family members has been discouraged. We examined the effect of genotype disclosure in a prospective, randomized, controlled trial. METHODS We randomly assigned 162 asymptomat... | Disclosure of APOE genotype for risk of Alzheimer's disease. |
{"1014": 0.3191637098789215, "1019": 0.14518201351165771, "1041": 0.401551216840744, "1044": 0.6338034868240356, "1046": 0.27786844968795776, "1999": 0.0752234235405922, "2001": 0.03925827145576477, "2007": 0.33675122261047363, "2019": 0.5968599319458008, "2022": 0.4879087805747986, "2026": 0.3547199070453644, "2039": ... | 4506414 | BACKGROUND The associations of blood pressure with the different manifestations of incident cardiovascular disease in a contemporary population have not been compared. In this study, we aimed to analyse the associations of blood pressure with 12 different presentations of cardiovascular disease. METHODS We used linked ... | Blood pressure and incidence of twelve cardiovascular diseases: lifetime risks, healthy life-years lost, and age-specific associations in 1·25 million people |
{"1003": 0.11256109178066254, "1019": 0.029824240133166313, "1020": 0.030771657824516296, "1041": 0.17759032547473907, "1050": 0.45437926054000854, "1052": 0.28597161173820496, "1053": 0.259204238653183, "1062": 0.2837681770324707, "1998": 0.15023678541183472, "2005": 0.18004031479358673, "2006": 0.14602625370025635, "... | 4506702 | BACKGROUND Ongoing initiatives to filter online health searches exclude consumer-generated content from search returns, though its inferiority compared with professionally controlled content is not demonstrated. The antidepressant escitalopram and the antipsychotic quetiapine have ranked over the last 5 years as top-se... | Can Online Consumers Contribute to Drug Knowledge? A Mixed-Methods Comparison of Consumer-Generated and Professionally Controlled Psychotropic Medication Information on the Internet |
{"1014": 0.4158279001712799, "1020": 0.04674193635582924, "1062": 0.8981585502624512, "2053": 0.17267228662967682, "2104": 0.02792670577764511, "2120": 0.053244512528181076, "2152": 0.013579257763922215, "2214": 0.11430477350950241, "2229": 0.43053874373435974, "2287": 0.848413348197937, "2312": 0.29255300760269165, "2... | 4515975 | BACKGROUND Multiple studies have been carried out to assess the effect of zinc supplementation on children's growth. The results of these studies are inconsistent, and the factors responsible for these varied outcomes are unknown. OBJECTIVE Meta-analyses of randomized controlled intervention trials were therefore compl... | Effect of supplemental zinc on the growth and serum zinc concentrations of prepubertal children: a meta-analysis of randomized controlled trials. |
{"1016": 0.03360854089260101, "1049": 0.28597161173820496, "1051": 0.27712854743003845, "1998": 0.41389304399490356, "2003": 0.24631060659885406, "2033": 0.31845372915267944, "2045": 0.3560888469219208, "2048": 0.7380234599113464, "2053": 0.19782574474811554, "2054": 0.056018441915512085, "2060": 0.1946154683828354, "2... | 4530659 | Age-related macular degeneration (AMD), a progressive condition that is untreatable in up to 90% of patients, is a leading cause of blindness in the elderly worldwide. The two forms of AMD, wet and dry, are classified based on the presence or absence of blood vessels that have disruptively invaded the retina, respectiv... | Mechanisms of Age-Related Macular Degeneration |
{"1011": 0.21293537318706512, "1043": 0.3850763738155365, "1050": 0.8641747236251831, "1057": 0.8091925978660583, "1996": 0.3012613356113434, "2015": 0.12986256182193756, "2029": 0.07793712615966797, "2051": 0.04487626627087593, "2076": 0.08244366943836212, "2079": 0.3547199070453644, "2114": 0.567397952079773, "2124":... | 4544916 | To efficiently counteract pathogens, plants rely on a complex set of immune responses that are tightly regulated to allow the timely activation, appropriate duration and adequate amplitude of defense programs. The coordination of the plant immune response is known to require the activity of the ubiquitin/proteasome sys... | The N-end rule pathway regulates pathogen responses in plants. |
{"1011": 0.08064348995685577, "1017": 0.17840765416622162, "1018": 0.42926809191703796, "1022": 0.7629209756851196, "1023": 0.4855078160762787, "1041": 0.9394577741622925, "1044": 0.45870962738990784, "1047": 0.7951818704605103, "1048": 0.5080875158309937, "2005": 0.11168810725212097, "2010": 0.8022117614746094, "2012"... | 4547102 | Aberrant epigenetic reprogramming often results in developmental defects in somatic cell nuclear transfer (SCNT) embryos during embryonic genome activation (EGA). Bovine eight-cell SCNT embryos exhibit global hypermethylation of histone H3 lysine 9 tri- and di-methylation (H3K9me3/2), but the intrinsic reason for this ... | H3K9 demethylase KDM4E is an epigenetic regulator for bovine embryonic development and a defective factor for nuclear reprogramming. |
{"1020": 0.28670501708984375, "1042": 1.0855059623718262, "1044": 0.6543170213699341, "2005": 0.12986256182193756, "2007": 0.04113444685935974, "2029": 0.026976587250828743, "2039": 0.04674193635582924, "2043": 0.32270604372024536, "2044": 0.6911921501159668, "2050": 0.20739519596099854, "2051": 0.04674193635582924, "2... | 4550036 | The authors investigated the association between folic acid supplementation and gestational hypertension. The study population included women with nonmalformed infants in the United States and Canada who were participating in the Slone Epidemiology Center Birth Defects Study between 1993 and 2000. Women were interviewe... | Risk of gestational hypertension in relation to folic acid supplementation during pregnancy. |
{"1009": 0.32341301441192627, "1015": 1.0172666311264038, "1045": 0.24401791393756866, "1052": 0.4196864068508148, "1055": 0.3963087201118469, "1056": 0.5723689198493958, "2003": 0.3519764244556427, "2013": 0.10555581003427505, "2015": 0.6892333030700684, "2028": 0.5640701055526733, "2063": 1.036847710609436, "2080": 0... | 4561402 | Autoimmune polyendocrinopathy syndrome type 1 is a recessive Mendelian disorder resulting from mutations in a novel gene, AIRE, and is characterized by a spectrum of organ-specific autoimmune diseases. It is not known what tolerance mechanisms are defective as a result of AIRE mutation. By tracing the fate of autoreact... | Aire regulates negative selection of organ-specific T cells |
{"1020": 0.46853771805763245, "1022": 0.11865071207284927, "1038": 0.10026945173740387, "1044": 0.2763880789279938, "2011": 0.021256839856505394, "2029": 0.1485546976327896, "2063": 0.2231435477733612, "2076": 0.03831886500120163, "2155": 0.25239890813827515, "2182": 0.034552380442619324, "2266": 0.0038986403960734606,... | 4583180 | Conditions of the tumor microenvironment, such as hypoxia and nutrient starvation, play critical roles in cancer progression. However, the role of acidic extracellular pH in cancer progression is not studied as extensively as that of hypoxia. Here, we show that extracellular acidic pH (pH 6.8) triggered activation of s... | Extracellular Acidic pH Activates the Sterol Regulatory Element-Binding Protein 2 to Promote Tumor Progression. |
{"1014": 0.2969166338443756, "1038": 0.5635144114494324, "1040": 0.5092619061470032, "1997": 0.1994270235300064, "2003": 0.2667117714881897, "2011": 0.056018441915512085, "2033": 0.472198486328125, "2035": 0.11256109178066254, "2051": 0.3283478021621704, "2079": 0.06246116757392883, "2094": 0.1718502640724182, "2101": ... | 4587978 | Patterns of daily human activity are controlled by an intrinsic circadian clock that promotes ∼24 hr rhythms in many behavioral and physiological processes. This system is altered in delayed sleep phase disorder (DSPD), a common form of insomnia in which sleep episodes are shifted to later times misaligned with the soc... | Mutation of the Human Circadian Clock Gene CRY1 in Familial Delayed Sleep Phase Disorder |
{"1011": 0.3070250153541565, "1043": 0.7305257320404053, "1044": 0.09228714555501938, "1048": 0.7295845746994019, "1052": 0.23402166366577148, "1054": 0.7389566898345947, "1999": 0.2470736801624298, "2011": 0.4349733293056488, "2029": 0.2852376699447632, "2046": 0.3339579105377197, "2049": 0.06612417846918106, "2064": ... | 4611267 | In rats, feeding can be triggered experimentally using many approaches. Included among these are (1) food deprivation and (2) acute microinjection of the neurotransmitter l-glutamate (Glu) or its receptor agonist NMDA into the lateral hypothalamic area (LHA). Under both paradigms, the NMDA receptor (NMDA-R) within the ... | Lateral Hypothalamic Signaling Mechanisms Underlying Feeding Stimulation: Differential Contributions of Src Family Tyrosine Kinases to Feeding Triggered Either by NMDA Injection or by Food Deprivation |
{"1011": 0.0058422754518687725, "1014": 0.26446542143821716, "1043": 0.7191727757453918, "1052": 0.2026219218969345, "1081": 0.6911921501159668, "2072": 0.1485546976327896, "2086": 0.3269403576850891, "2090": 0.22001366317272186, "2109": 0.29981520771980286, "2111": 0.0842406153678894, "2116": 0.0019512200960889459, "2... | 4627816 | AIM The present study aimed to investigate the relationship between advanced glycation end-product accumulation and skeletal muscle mass among middle-aged and older Japanese men and women. METHODS A total of 132 participants enrolled in this cross-sectional study. Skin autofluorescence was assessed as a measure of adva... | Relationship between advanced glycation end‐product accumulation and low skeletal muscle mass in Japanese men and women |
{"1011": 0.06612417846918106, "1019": 0.006812678650021553, "1041": 0.841701865196228, "1053": 0.19622190296649933, "1060": 0.5415972471237183, "1998": 0.04674193635582924, "2008": 0.1212492436170578, "2013": 0.12986256182193756, "2015": 0.22548456490039825, "2020": 0.0606246218085289, "2029": 0.1734936386346817, "2057... | 4632921 | In this study, we used whole-genome sequencing and gene expression profiling of 215 human induced pluripotent stem cell (iPSC) lines from different donors to identify genetic variants associated with RNA expression for 5,746 genes. We were able to predict causal variants for these expression quantitative trait loci (eQ... | Large-Scale Profiling Reveals the Influence of Genetic Variation on Gene Expression in Human Induced Pluripotent Stem Cells. |
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