spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1041": 0.37304413318634033, "1050": 0.49626702070236206, "1051": 0.8281423449516296, "1059": 0.7546905279159546, "2002": 0.6704301834106445, "2003": 0.15943801403045654, "2005": 0.23710809648036957, "2011": 0.021256839856505394, "2012": 0.2018241584300995, "2035": 0.8091925978660583, "2050": 0.500420093536377, "2094"... | 4641348 | BACKGROUND/OBJECTIVES Non-alcoholic fatty liver disease (NAFLD) is a leading cause of chronic liver disease and is closely associated with metabolic syndrome. In the present study, we observed the effect of ethanol extract of Allium fistulosum (EAF) on NAFLD and have suggested the possibility of using EAF as a natural ... | Ethanol extract of Allium fistulosum inhibits development of non-alcoholic fatty liver disease |
{"1023": 0.03831886500120163, "1026": 0.1734936386346817, "1039": 0.5601736903190613, "1052": 0.5662899017333984, "2012": 0.5404602885246277, "2020": 0.052318159490823746, "2043": 0.14686977863311768, "2044": 0.1808556467294693, "2076": 0.4113073945045471, "2080": 0.3027053773403168, "2086": 0.4196864068508148, "2089":... | 4647303 | CONTEXT Exposure to cardiovascular risk factors during childhood and adolescence may be associated with the development of atherosclerosis later in life. OBJECTIVE To study the relationship between cardiovascular risk factors measured in childhood and adolescence and common carotid artery intima-media thickness (IMT), ... | Cardiovascular risk factors in childhood and carotid artery intima-media thickness in adulthood: the Cardiovascular Risk in Young Finns Study. |
{"1011": 0.36358460783958435, "1015": 0.3810817003250122, "1038": 0.5557019114494324, "1045": 0.8433839678764343, "1052": 0.436867892742157, "1053": 0.6487176418304443, "1059": 0.6244332790374756, "1156": 0.4412745535373688, "2011": 0.2637155055999756, "2012": 0.6107416749000549, "2026": 1.0815403461456299, "2029": 0.2... | 4653837 | The mechanisms underlying the development of aging-induced muscle atrophy are unclear. By microRNA array and individual qPCR analyses, we found significant up-regulation of miR-29 in muscles of aged rodents vs. results in young. With aging, p85α, IGF-1 and B-myb muscle levels were lower while the expression of certain ... | MicroRNA-29 induces cellular senescence in aging muscle through multiple signaling pathways |
{"1011": 0.23864774405956268, "1039": 0.13670019805431366, "1052": 0.4431571960449219, "1055": 0.304147332906723, "1996": 0.2247048318386078, "2003": 0.2105647772550583, "2007": 0.28963330388069153, "2008": 0.14179791510105133, "2011": 0.23247487843036652, "2029": 0.259204238653183, "2079": 0.1734936386346817, "2080": ... | 4658268 | The mammalian TOR (mTOR) pathway integrates nutrient- and growth factor-derived signals to regulate growth, the process whereby cells accumulate mass and increase in size. mTOR is a large protein kinase and the target of rapamycin, an immunosuppressant that also blocks vessel restenosis and has potential anticancer app... | Rictor, a Novel Binding Partner of mTOR, Defines a Rapamycin-Insensitive and Raptor-Independent Pathway that Regulates the Cytoskeleton |
{"1011": 0.18248429894447327, "1015": 0.3297532796859741, "1041": 0.7755908370018005, "1045": 0.6764062643051147, "1047": 0.05139094591140747, "1996": 0.0354953333735466, "1997": 0.09228714555501938, "2005": 0.2089812457561493, "2008": 0.07793712615966797, "2011": 0.4950772523880005, "2012": 0.17840765416622162, "2029"... | 4662264 | The phosphorylation of the human estrogen receptor (ER) serine residue at position 118 is required for full activity of the ER activation function 1 (AF-1). This Ser118 is phosphorylated by mitogen-activated protein kinase (MAPK) in vitro and in cells treated with epidermal growth factor (EGF) and insulin-like growth f... | Activation of the estrogen receptor through phosphorylation by mitogen-activated protein kinase. |
{"1011": 0.2786078155040741, "1048": 0.2786078155040741, "1050": 0.18573370575904846, "1054": 0.22704219818115234, "1997": 0.0174254160374403, "2003": 0.22001366317272186, "2008": 0.06795065850019455, "2011": 0.2689530849456787, "2024": 0.22626367211341858, "2066": 0.39433568716049194, "2079": 0.23864774405956268, "209... | 4664540 | Nucleotide-binding, oligomerization domain (NOD)-like receptor (NLR) proteins are a family of innate immune receptors that play a pivotal role in microbial sensing, leading to the initiation of antimicrobial immune responses. Dysregulation of the function of multiple NLR family members has been linked, both in mice and... | Regulation of the antimicrobial response by NLR proteins. |
{"1013": 0.02792670577764511, "1022": 0.030771657824516296, "1048": 0.28082266449928284, "1052": 0.09938567131757736, "2005": 0.0354953333735466, "2039": 0.0009760859538801014, "2043": 0.07341018319129944, "2044": 0.6096806526184082, "2051": 0.3464667797088623, "2063": 0.5301685929298401, "2076": 0.40285754203796387, "... | 4678846 | CONTEXT The antioxidant acetylcysteine prevents acute contrast nephrotoxicity in patients with impaired renal function who undergo computed tomography scanning. However, its role in coronary angiography is unclear. OBJECTIVE To determine whether oral acetylcysteine prevents acute deterioration in renal function in pati... | Acetylcysteine for prevention of acute deterioration of renal function following elective coronary angiography and intervention: a randomized controlled trial. |
{"1022": 0.11865071207284927, "1040": 0.23402166366577148, "2011": 0.07250232994556427, "2012": 0.1718502640724182, "2020": 0.02792670577764511, "2033": 0.176772341132164, "2034": 0.09050461649894714, "2043": 0.176772341132164, "2044": 0.3297532796859741, "2075": 0.15943801403045654, "2076": 0.5495203733444214, "2078":... | 4679264 | The role of DNA cytosine methylation, an epigenetic regulator of chromatin structure and function, during normal and pathological brain development and aging remains unclear. Here, we examined by MethyLight PCR the DNA methylation status at 50 loci, encompassing primarily 5′ CpG islands of genes related to CNS growth a... | DNA Methylation in the Human Cerebral Cortex Is Dynamically Regulated throughout the Life Span and Involves Differentiated Neurons |
{"1016": 0.4450363218784332, "1018": 0.21135559678077698, "1042": 0.11256109178066254, "1043": 0.1734936386346817, "1044": 0.6466736793518066, "1048": 0.28670501708984375, "1155": 0.1994270235300064, "1999": 0.08154398202896118, "2002": 0.75193190574646, "2003": 0.08244366943836212, "2005": 0.3903779089450836, "2007": ... | 4680262 | Obesity is associated with chronic diseases such as fatty liver, type 2 diabetes, cardiovascular disease, and severe metabolic syndrome. Obesity causes metabolic impairment including excessive lipid accumulation and fibrosis in the hepatic tissue as well as the increase in oxidative stress. In order to investigate the ... | Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice |
{"1011": 0.25694093108177185, "1014": 0.4158279001712799, "1017": 0.43244171142578125, "1037": 0.3883931338787079, "1051": 0.06429435312747955, "2004": 0.23787821829319, "2005": 0.259204238653183, "2043": 0.12814582884311676, "2044": 0.6833335757255554, "2050": 0.3318578004837036, "2051": 0.11691460013389587, "2053": 0... | 4687948 | CONTEXT Recent animal studies have found that 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) lipid-lowering drugs (statins) substantially increase bone formation, but whether statin use in humans results in clinically meaningful bone formation or a reduction in the risk of osteoporotic fractures is not known. OBJECTIV... | HMG-CoA reductase inhibitors and the risk of hip fractures in elderly patients. |
{"1003": 0.1332872211933136, "1020": 0.08154398202896118, "1041": 0.27934664487838745, "2001": 0.0058422754518687725, "2022": 0.012615402229130268, "2043": 0.25694093108177185, "2045": 0.018384648486971855, "2087": 0.045809537172317505, "2092": 0.3283478021621704, "2095": 0.06520967930555344, "2109": 0.5968599319458008... | 4688277 | The ecologic study design is routinely used by epidemiologists in spite of its limitations. It is presently unknown how well the challenges of the design are dealt with in epidemiologic research. The purpose of this bibliometric review was to critically evaluate the characteristics, statistical methods, and reporting o... | The quality of modern cross-sectional ecologic studies: a bibliometric review. |
{"1011": 0.17267228662967682, "1020": 0.1808556467294693, "1038": 0.4574742913246155, "1041": 0.7220231294631958, "1043": 0.6265231370925903, "1044": 0.5168620347976685, "1060": 0.4419025182723999, "1156": 0.6793810129165649, "1998": 0.05046287178993225, "2000": 0.15693697333335876, "2004": 0.1905880719423294, "2005": ... | 4688340 | BACKGROUND Resistance to radiotherapy continues to be a limiting factor in the treatment of cancer including head and neck squamous cell carcinoma (HNSCC). Simultaneous targeting of β1 integrin and EGFR was shown to have a higher radiosensitizing potential than mono-targeting in the majority of tested HNSCC cancer mode... | Efficacy of Beta1 Integrin and EGFR Targeting in Sphere-Forming Human Head and Neck Cancer Cells |
{"1014": 0.3547199070453644, "1018": 0.07068414986133575, "1053": 0.045809537172317505, "1054": 0.026025565341114998, "1997": 0.11343330889940262, "2000": 0.007782140281051397, "2004": 0.4041621685028076, "2007": 0.0038986403960734606, "2009": 0.020300358533859253, "2011": 0.016465263441205025, "2015": 0.25542920827865... | 4695046 | OBJECTIVES To examine the effect of routinely administered psychiatric questionnaires on the recognition, management, and outcome of psychiatric disorders in non-psychiatric settings. DATA SOURCES Embase, Medline, PsycLIT, Cinahl, Cochrane Controlled Trials Register, and hand searches of key journals. METHODS A systema... | Anxiety |
{"1041": 0.3750596046447754, "1049": 0.11168810725212097, "1997": 0.3601844012737274, "2000": 0.07341018319129944, "2003": 0.16110190749168396, "2004": 0.06429435312747955, "2007": 0.3923587501049042, "2011": 0.23402166366577148, "2013": 0.06703783571720123, "2024": 0.0029254043474793434, "2026": 0.5404602885246277, "2... | 4695107 | The problem of antibiotic resistance, which has limited the use of cheap and old antibiotics, has necessitated the need for a continued search for new antimicrobial compounds. Understanding the mechanisms of resistance is important in the development of strategies to solving the problem. Active efflux of drugs, alterat... | The challenges of overcoming antibiotic resistance: Plant extracts as potential sources of antimicrobial and resistance modifying agents |
{"1011": 0.006812678650021553, "1017": 0.2837681770324707, "1019": 0.33115679025650024, "1043": 0.5914691090583801, "1050": 0.21214580535888672, "1052": 0.5404602885246277, "1999": 0.07793712615966797, "2000": 0.1930064558982849, "2007": 0.15943801403045654, "2011": 0.15610189735889435, "2029": 0.19862671196460724, "20... | 4700428 | BACKGROUND Relapse to cocaine seeking has been linked with low glutamate in the nucleus accumbens core (NAcore) causing potentiation of synaptic glutamate transmission from prefrontal cortex (PFC) afferents. Systemic N-acetylcysteine (NAC) has been shown to restore glutamate homeostasis, reduce relapse to cocaine seeki... | The effect of N-acetylcysteine in the nucleus accumbens on neurotransmission and relapse to cocaine. |
{"1011": 0.3084607720375061, "1043": 0.1485546976327896, "1052": 0.3949938118457794, "1996": 0.37640097737312317, "1998": 0.12470348179340363, "1999": 0.21765978634357452, "2000": 0.21214580535888672, "2004": 0.18004031479358673, "2005": 0.06429435312747955, "2007": 0.05046287178993225, "2013": 0.2749055027961731, "201... | 4701662 | As phospholipids are synthesized mainly in the endoplasmic reticulum (ER) and mitochondrial inner membranes, how cells properly distribute specific phospholipids to diverse cellular membranes is a crucial problem for maintenance of organelle-specific phospholipid compositions. Although the ER-mitochondria encounter str... | A phospholipid transfer function of ER-mitochondria encounter structure revealed in vitro |
{"1017": 0.3423145115375519, "1047": 0.7592713832855225, "1050": 0.5607312321662903, "1058": 0.04207121208310127, "1060": 0.3526630103588104, "1155": 0.8861536383628845, "1164": 0.7248653769493103, "2004": 0.13414156436920166, "2005": 0.2145126610994339, "2007": 0.1873544454574585, "2008": 0.04394211992621422, "2029": ... | 4702639 | Tumour cells, with stem-like properties, are highly aggressive and often show drug resistance. Here, we reveal that integrin αvβ3 serves as a marker of breast, lung and pancreatic carcinomas with stem-like properties that are highly resistant to receptor tyrosine kinase inhibitors such as erlotinib. This was observed i... | An integrin β3–KRAS–RalB complex drives tumour stemness and resistance to EGFR inhibition |
{"1011": 0.1751343309879303, "1017": 0.07793712615966797, "1018": 0.23787821829319, "1037": 0.39696553349494934, "1041": 0.7352184057235718, "1156": 0.3656192123889923, "2005": 0.4311734735965729, "2008": 0.07250232994556427, "2011": 0.15275461971759796, "2013": 0.2674594223499298, "2029": 0.3019835948944092, "2080": 0... | 4709641 | Efforts to develop drugs for Alzheimer's disease (AD) have shown promise in animal studies, only to fail in human trials, suggesting a pressing need to study AD in human model systems. Using human neurons derived from induced pluripotent stem cells that expressed apolipoprotein E4 (ApoE4), a variant of the APOE gene pr... | Gain of toxic Apolipoprotein E4 effects in Human iPSC-Derived Neurons Is Ameliorated by a Small-Molecule Structure Corrector |
{"1011": 0.3588210940361023, "1015": 0.32764431834220886, "1019": 0.5562619566917419, "1021": 0.6950984001159668, "1038": 0.05786345899105072, "1052": 0.41647201776504517, "1053": 0.5952457785606384, "1060": 0.5313173532485962, "1061": 0.38374659419059753, "1999": 0.014542185701429844, "2004": 0.10467668622732162, "200... | 4729644 | The long non-coding RNA nuclear paraspeckle assembly transcript 1 (NEAT1) was reported to be upregulated and be involved in oncogenic growth and drug resistance in nasopharyngeal carcinoma (NPC). However, the exact roles of NEAT1 and its underlying mechanisms in the drug resistance of NPC remain largely unclear. In thi... | LncRNA NEAT1/let-7a-5p axis regulates the cisplatin resistance in nasopharyngeal carcinoma by targeting Rsf-1 and modulating the Ras-MAPK pathway. |
{"1011": 0.10993985831737518, "1046": 0.9500881433486938, "1050": 0.17759032547473907, "1999": 0.10555581003427505, "2004": 0.06520967930555344, "2008": 0.040196798741817474, "2011": 0.42990362644195557, "2012": 0.16690383851528168, "2029": 0.2184450328350067, "2036": 0.30558720231056213, "2039": 0.5506471395492554, "2... | 4740447 | The antibacterial peptide microcin J25 (MccJ25) inhibits transcription by bacterial RNA polymerase (RNAP). Biochemical results indicate that inhibition of transcription occurs at the level of NTP uptake or NTP binding by RNAP. Genetic results indicate that inhibition of transcription requires an extensive determinant, ... | Antibacterial peptide microcin J25 inhibits transcription by binding within and obstructing the RNA polymerase secondary channel. |
{"1020": 0.43434104323387146, "1996": 0.09495500475168228, "2003": 0.16110190749168396, "2005": 0.07250232994556427, "2033": 0.49982786178588867, "2075": 0.06154331564903259, "2079": 0.17840765416622162, "2092": 0.16110190749168396, "2109": 0.1485546976327896, "2128": 0.3601844012737274, "2173": 0.5751199722290039, "22... | 4767806 | Maintenance and accurate propagation of the genetic material are key features for physiological development and wellbeing. The replication licensing machinery is crucial for replication precision as it ensures that replication takes place once per cell cycle. Thus, the expression status of the components comprising the... | Exploring and exploiting the systemic effects of deregulated replication licensing. |
{"1011": 0.006812678650021553, "1041": 0.29473719000816345, "1052": 0.14686977863311768, "2003": 0.23633737862110138, "2028": 0.4580921530723572, "2035": 0.5063233375549316, "2054": 0.2105647772550583, "2064": 0.09584271162748337, "2075": 0.05046287178993225, "2110": 0.34370049834251404, "2121": 0.4450363218784332, "21... | 4784069 | Pluripotency is the remarkable capacity of a single cell to engender all the specialized cell types of an adult organism. This property can be captured indefinitely through derivation of self-renewing embryonic stem cells (ESCs), which represent an invaluable platform to investigate cell fate decisions and disease. Rec... | Regulatory principles of pluripotency: from the ground state up. |
{"1003": 0.30989447236061096, "1014": 0.2184450328350067, "1019": 0.2852376699447632, "1997": 0.055094651877880096, "2001": 0.018384648486971855, "2035": 0.32129061222076416, "2042": 0.28450319170951843, "2043": 0.1751343309879303, "2057": 0.004870930220931768, "2058": 0.04860413447022438, "2065": 0.1221139207482338, "... | 4791384 | BACKGROUND Historically, the main focus of studies of childhood mortality has been the infant and under-five mortality rates. Neonatal mortality (deaths <28 days of age) has received limited attention, although such deaths account for about 41% of all child deaths. To better assess progress, we developed annual estimat... | Neonatal Mortality Levels for 193 Countries in 2009 with Trends since 1990: A Systematic Analysis of Progress, Projections, and Priorities |
{"1011": 0.1677299439907074, "1016": 0.5789587497711182, "1042": 0.2018241584300995, "1043": 0.4734157919883728, "1044": 0.03266380727291107, "1050": 0.45994341373443604, "1052": 0.26296505331993103, "1062": 0.6674286723136902, "2003": 0.1685553640127182, "2005": 0.176772341132164, "2007": 0.1358480453491211, "2029": 0... | 4795303 | Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor against oxidative stress and neurodegenerative disorders. Phenylethanoid glycosides (PhGs; salidroside, acteoside, isoacteoside, and echinacoside) exhibit antioxidant and neuroprotective bioactivities. This study was performed to investiga... | Neuroprotective Effects of Four Phenylethanoid Glycosides on H2O2-Induced Apoptosis on PC12 Cells via the Nrf2/ARE Pathway |
{"1003": 0.18573370575904846, "1014": 0.45499902963638306, "1021": 0.06977381557226181, "1997": 0.09228714555501938, "1998": 0.14518201351165771, "2001": 0.040196798741817474, "2011": 0.1011524572968483, "2012": 0.6348392367362976, "2020": 0.07612881064414978, "2043": 0.036437395960092545, "2051": 0.17922431230545044, ... | 4810810 | BACKGROUND Although studies have provided estimates of premature deaths attributable to either heat or cold in selected countries, none has so far offered a systematic assessment across the whole temperature range in populations exposed to different climates. We aimed to quantify the total mortality burden attributable... | Mortality risk attributable to high and low ambient temperature: a multicountry observational study |
{"1009": 0.006812678650021553, "1011": 0.2105647772550583, "1013": 0.018384648486971855, "1052": 0.5914691090583801, "1999": 0.0797421783208847, "2003": 0.4950772523880005, "2005": 0.3982778787612915, "2008": 0.0913962796330452, "2011": 0.058784693479537964, "2025": 0.030771657824516296, "2029": 0.23324857652187347, "2... | 4816339 | Survivin is a member of the chromosome passenger complex, which plays an important role in chromosome alignment, separation, and cytokinesis. Although survivin is required for the proliferation and survival of hematopoietic stem and progenitor cells, the extent to which it is necessary for endomitosis of megakaryocytes... | Survivin is not required for the endomitotic cell cycle of megakaryocytes. |
{"1011": 0.09850110858678818, "1015": 0.053244512528181076, "1016": 0.21530038118362427, "1017": 0.0019512200960889459, "1041": 0.4067663550376892, "1048": 0.3683255612850189, "1056": 0.503966212272644, "1156": 0.791648268699646, "2004": 0.11081436276435852, "2005": 0.08154398202896118, "2006": 0.009718249551951885, "2... | 4820792 | INTRODUCTION The overexpression of human epidermal growth factor receptor (HER)-2 in 20% of human breast cancers and its association with aggressive growth has led to widespread use of HER2-targeted therapies, such as trastuzumab (T) and lapatinib (L). Despite the success of these drugs, their efficacy is limited in pa... | β1 integrin mediates an alternative survival pathway in breast cancer cells resistant to lapatinib |
{"1003": 0.21135559678077698, "1014": 0.29328158497810364, "1017": 0.02412080205976963, "1020": 0.16607704758644104, "1041": 0.10906458646059036, "1052": 0.3676496744155884, "1057": 0.21372433006763458, "1061": 0.7201237678527832, "1997": 0.16690383851528168, "2001": 0.10026945173740387, "2015": 0.11256109178066254, "2... | 4824840 | Importance Estimates from claims-based analyses suggest that the incidence of sepsis is increasing and mortality rates from sepsis are decreasing. However, estimates from claims data may lack clinical fidelity and can be affected by changing diagnosis and coding practices over time. Objective To estimate the US nationa... | Incidence and Trends of Sepsis in US Hospitals Using Clinical vs Claims Data, 2009-2014 |
{"1014": 0.39893341064453125, "1023": 0.10203468054533005, "1038": 0.9776504039764404, "1044": 0.013579257763922215, "1051": 0.23092569410800934, "1052": 0.3241194784641266, "2011": 0.07068414986133575, "2035": 0.2089812457561493, "2062": 0.022212404757738113, "2072": 0.07884006202220917, "2087": 0.3995884954929352, "2... | 4828631 | BACKGROUND High body-mass index (BMI) predisposes to several site-specific cancers, but a large-scale systematic and detailed characterisation of patterns of risk across all common cancers adjusted for potential confounders has not previously been undertaken. We aimed to investigate the links between BMI and the most c... | Body-mass index and risk of 22 specific cancers: a population-based cohort study of 5·24 million UK adults |
{"1011": 0.42608439922332764, "1016": 0.5629584193229675, "1017": 0.4286321699619293, "1044": 0.20739519596099854, "1996": 0.1384023278951645, "1997": 0.35950297117233276, "1999": 0.0317181795835495, "2002": 1.0492360591888428, "2007": 0.04953393340110779, "2010": 0.012615402229130268, "2012": 0.03360854089260101, "201... | 4828984 | Structurally and genetically, human herpesviruses are among the largest and most complex of viruses. Using cryo–electron microscopy (cryo-EM) with an optimized image reconstruction strategy, we report the herpes simplex virus type 2 (HSV-2) capsid structure at 3.1 angstroms, which is built up of about 3000 proteins org... | Cryo-EM structure of a herpesvirus capsid at 3.1 Å |
{"1017": 0.22392450273036957, "1044": 0.1889725625514984, "1998": 0.009718249551951885, "2000": 0.18654440343379974, "2028": 0.3297532796859741, "2043": 0.25995752215385437, "2045": 0.06977381557226181, "2048": 0.5662899017333984, "2054": 0.07431721687316895, "2062": 0.5381823778152466, "2064": 0.38174858689308167, "20... | 4833016 | Hypotheses involving mediation are common in the behavioral sciences. Mediation exists when a predictor affects a dependent variable indirectly through at least one intervening variable, or mediator. Methods to assess mediation involving multiple simultaneous mediators have received little attention in the methodologic... | Asymptotic and resampling strategies for assessing and comparing indirect effects in multiple mediator models. |
{"1997": 0.09406650811433792, "1998": 0.0009760859538801014, "1999": 0.1332872211933136, "2004": 0.1485546976327896, "2022": 0.01934296265244484, "2025": 0.083342544734478, "2029": 0.32553088665008545, "2035": 0.09938567131757736, "2057": 0.0317181795835495, "2062": 0.15693697333335876, "2065": 0.0019512200960889459, "... | 4841908 | Alterations in metabolism influence lifespan in experimental models, but data in humans are lacking. Here we use liquid chromatography/mass spectrometry to quantify 217 plasma metabolites and examine their relation to longevity in a large cohort of men and women followed for up to 20 years. We find that, higher concent... | Distinct Metabolomic Signatures Are Associated with Longevity in Humans |
{"1040": 0.08782484382390976, "2029": 0.0770333781838417, "2045": 0.004870930220931768, "2058": 0.10203468054533005, "2062": 0.0606246218085289, "2064": 0.3134697377681732, "2076": 0.19541899859905243, "2079": 0.11256109178066254, "2109": 0.07884006202220917, "2129": 0.036437395960092545, "2139": 0.9425065517425537, "2... | 4854076 | The rising incidence of obesity and associated metabolic diseases has increased the urgency in understanding all aspects of adipose tissue biology. This includes the function of adipocytes, how adipose tissue expands in obesity, and how expanded adipose tissues in adults can impact physiology. Here, we highlight the gr... | The expanding problem of adipose depot remodeling and postnatal adipocyte progenitor recruitment. |
{"1020": 0.0770333781838417, "1048": 0.15943801403045654, "1157": 0.5232481360435486, "2003": 0.10379679501056671, "2006": 0.46117570996284485, "2048": 0.5882205963134766, "2060": 0.06886265426874161, "2090": 0.10026945173740387, "2092": 0.0606246218085289, "2104": 0.38308101892471313, "2114": 0.04394211992621422, "212... | 4856149 | BACKGROUND Clonal competition in cancer describes the process in which the progeny of a cell clone supersedes or succumbs to other competing clones due to differences in their functional characteristics, mostly based on subsequently acquired mutations. Even though the patterns of those mutations are well explored in ma... | Clonal competition in BcrAbl-driven leukemia: how transplantations can accelerate clonal conversion |
{"1012": 0.18411032855510712, "1013": 0.33115679025650024, "1014": 0.8161250352859497, "1016": 0.791648268699646, "1017": 0.23864774405956268, "1039": 0.11430477350950241, "1045": 0.1358480453491211, "1046": 0.03360854089260101, "2003": 0.13925230503082275, "2015": 0.06795065850019455, "2048": 0.6254787445068359, "2054... | 4857085 | BACKGROUND A frequent problem in computational modeling is the interconversion of chemical structures between different formats. While standard interchange formats exist (for example, Chemical Markup Language) and de facto standards have arisen (for example, SMILES format) , the need to interconvert formats is a contin... | Open Babel: An open chemical toolbox |
{"1011": 0.4311734735965729, "1014": 0.24631060659885406, "1039": 0.803087055683136, "1044": 0.15943801403045654, "1050": 0.1946154683828354, "1061": 0.31845372915267944, "1164": 0.5104349255561829, "1999": 0.25694093108177185, "2007": 0.21765978634357452, "2020": 0.09850110858678818, "2029": 0.04674193635582924, "2050... | 4857093 | Objective:To assess the relative validity and acceptability of the computerised 24-h recall ‘Young Adolescent's Nutrition Assessment on Computer (YANA-C)’.Design:Food and nutrient intakes assessed with YANA-C were compared with food records (study 1) and 24-h dietary recall interviews (study 2).Main outcome measures:In... | Young adolescents' nutrition assessment on computer (YANA-C) |
{"1003": 0.009718249551951885, "1013": 0.0029254043474793434, "1014": 0.6624060273170471, "1018": 0.42608439922332764, "1020": 0.021256839856505394, "1039": 0.23247487843036652, "1052": 0.48610860109329224, "1085": 0.36358460783958435, "1997": 0.009718249551951885, "2001": 0.022212404757738113, "2007": 0.18329764902591... | 4883040 | BACKGROUND Human immunodeficiency virus (HIV) infection is the strongest risk factor for developing tuberculosis and has fuelled its resurgence, especially in sub-Saharan Africa. In 2010, there were an estimated 1.1 million incident cases of tuberculosis among the 34 million people living with HIV worldwide. Antiretrov... | Antiretroviral Therapy for Prevention of Tuberculosis in Adults with HIV: A Systematic Review and Meta-Analysis |
{"1016": 0.7951818704605103, "1998": 0.18411032855510712, "2007": 0.09317722171545029, "2015": 0.053244512528181076, "2038": 0.1485546976327896, "2048": 0.43244171142578125, "2058": 0.07612881064414978, "2064": 0.10906458646059036, "2071": 0.045809537172317505, "2084": 0.07159364968538284, "2089": 0.22001366317272186, ... | 4886637 | Incidences of breast cancer, type 2 diabetes, and metabolic syndrome have increased over the past decades with the obesity epidemic, especially in industrialized countries. Insulin resistance, hyperinsulinemia, and changes in the signaling of growth hormones and steroid hormones associated with diabetes may affect the ... | Diabetes, metabolic syndrome, and breast cancer: a review of the current evidence. |
{"1011": 0.129004567861557, "1017": 0.3027053773403168, "1040": 0.24631060659885406, "1056": 0.41195443272590637, "2005": 0.11168810725212097, "2007": 0.13670019805431366, "2011": 0.29981520771980286, "2029": 0.33953672647476196, "2058": 0.3903779089450836, "2075": 0.5712664127349854, "2087": 0.14264501631259918, "2091... | 4889228 | Aberrant alternative splicing has been highlighted as a potential hallmark of cancer. Here, we identify TDP43 (TAR DNA-binding protein 43) as an important splicing regulator responsible for the unique splicing profile in triple-negative breast cancer (TNBC). Clinical data demonstrate that TDP43 is highly expressed in T... | Loss of TDP43 inhibits progression of triple-negative breast cancer in coordination with SRSF3 |
{"1009": 0.08244366943836212, "1018": 0.12556517124176025, "1019": 0.25467249751091003, "1020": 0.4770587682723999, "1021": 0.004870930220931768, "1039": 0.3615458607673645, "1051": 0.6369074583053589, "1999": 0.15526613593101501, "2004": 0.06337817758321762, "2006": 0.016465263441205025, "2011": 0.021256839856505394, ... | 4890578 | Time for primary reveiw 27 days Atherosclerosis continues to be one of the main subjects in pathology research. The intriguing complexity of its pathogenesis as well as the importance of its clinical sequelae provide a rationale for this [1]. A large number of diseases with totally different clinical presentations ar... | Atherosclerotic plaque rupture--pathologic basis of plaque stability and instability. |
{"1021": 0.7295845746994019, "1052": 0.6553317308425903, "1060": 0.46670228242874146, "2005": 0.2837681770324707, "2011": 0.37371641397476196, "2012": 0.20102575421333313, "2028": 0.23402166366577148, "2029": 0.3269403576850891, "2034": 0.0354953333735466, "2043": 0.03831886500120163, "2044": 0.1602703034877777, "2047"... | 4896726 | Pioneer transcription factors establish new cell-fate competence by triggering chromatin remodeling. However, many features of pioneer action, such as their kinetics and stability, remain poorly defined. Here, we show that Pax7, by opening a unique repertoire of enhancers, is necessary and sufficient for specification ... | Pioneer factor Pax7 deploys a stable enhancer repertoire for specification of cell fate |
{"1011": 0.034552380442619324, "1022": 0.09228714555501938, "2008": 0.06246116757392883, "2011": 0.19782574474811554, "2012": 0.25088030099868774, "2015": 0.5596157908439636, "2025": 0.13414156436920166, "2029": 0.25467249751091003, "2033": 0.4286321699619293, "2043": 0.13071982562541962, "2050": 0.06612417846918106, "... | 4899981 | Telomeres resemble common fragile sites (CFSs) in that they are difficult-to-replicate and exhibit fragility in mitosis in response to DNA replication stress. At CFSs, this fragility is associated with a delay in the completion of DNA replication until early mitosis, whereupon cells are proposed to switch to a RAD52-de... | Human cancer cells utilize mitotic DNA synthesis to resist replication stress at telomeres regardless of their telomere maintenance mechanism |
{"1014": 0.18816383183002472, "1017": 0.18167030811309814, "1019": 0.1477125883102417, "1020": 0.2689530849456787, "1039": 0.6754127144813538, "1040": 0.27564704418182373, "2007": 0.07793712615966797, "2012": 0.401551216840744, "2015": 0.32129061222076416, "2029": 0.013579257763922215, "2043": 0.016465263441205025, "20... | 4910408 | Essentials Direct oral anticoagulants (DOACs) do not require laboratory monitoring currently. DOAC specific measurements were performed at trough in patients with atrial fibrillation. Patients who developed thromboembolic events showed lower DOAC plasma levels. This study supports the concept of measuring DOAC levels a... | Low drug levels and thrombotic complications in high‐risk atrial fibrillation patients treated with direct oral anticoagulants |
{"2000": 0.24018502235412598, "2003": 0.02316705882549286, "2004": 0.022212404757738113, "2005": 0.08603433519601822, "2015": 0.1384023278951645, "2042": 0.04674193635582924, "2046": 0.12986256182193756, "2064": 0.28963330388069153, "2079": 0.0752234235405922, "2083": 0.7124901413917542, "2094": 1.02149498462677, "2099... | 4911006 | Apoptotic cells have long been considered as intrinsically tolerogenic or unable to elicit immune responses specific for dead cell-associated antigens. However, multiple stimuli can trigger a functionally peculiar type of apoptotic demise that does not go unnoticed by the adaptive arm of the immune system, which we nam... | Consensus guidelines for the detection of immunogenic cell death. |
{"1011": 0.037378571927547455, "1017": 0.3676496744155884, "1047": 0.9052929878234863, "1049": 0.0019512200960889459, "1054": 0.07612881064414978, "2007": 0.0019512200960889459, "2011": 0.30558720231056213, "2012": 0.10026945173740387, "2020": 0.034552380442619324, "2026": 0.6970458030700684, "2029": 0.1800403147935867... | 4920376 | Induction of compensatory mechanisms and ERK reactivation has limited the effectiveness of Raf and MEK inhibitors in RAS-mutant cancers. We determined that direct pharmacologic inhibition of ERK suppressed the growth of a subset of KRAS-mutant pancreatic cancer cell lines and that concurrent phosphatidylinositol 3-kina... | Long-Term ERK Inhibition in KRAS-Mutant Pancreatic Cancer Is Associated with MYC Degradation and Senescence-like Growth Suppression. |
{"1011": 0.35745587944984436, "1015": 0.27934664487838745, "1039": 0.0752234235405922, "1044": 0.3163207769393921, "1045": 0.25845035910606384, "1054": 0.4818955361843109, "1055": 0.6734226942062378, "1056": 0.7191727757453918, "1996": 0.129004567861557, "2002": 0.7701805830001831, "2007": 0.24018502235412598, "2011": ... | 4926049 | The helicase RTEL1 promotes t-loop unwinding and suppresses telomere fragility to maintain the integrity of vertebrate telomeres. An interaction between RTEL1 and PCNA is important to prevent telomere fragility, but how RTEL1 engages with the telomere to promote t-loop unwinding is unclear. Here, we establish that the ... | TRF2 Recruits RTEL1 to Telomeres in S Phase to Promote T-Loop Unwinding |
{"1011": 0.11865071207284927, "1996": 0.24171993136405945, "1999": 0.01934296265244484, "2007": 0.19622190296649933, "2011": 0.025073638185858727, "2012": 0.5313173532485962, "2029": 0.3070250153541565, "2031": 0.32905077934265137, "2038": 0.19220098853111267, "2079": 0.2786078155040741, "2083": 0.27786844968795776, "2... | 4928057 | Organ-specific functions of tissue-resident macrophages in the steady-state heart are unknown. Here, we show that cardiac macrophages facilitate electrical conduction through the distal atrioventricular node, where conducting cells densely intersperse with elongated macrophages expressing connexin 43. When coupled to s... | Macrophages Facilitate Electrical Conduction in the Heart |
{"1004": 0.08961215615272522, "1025": 0.11168810725212097, "1049": 0.14433705806732178, "2011": 0.23787821829319, "2015": 0.02887592278420925, "2058": 0.562402069568634, "2075": 0.3656192123889923, "2076": 0.3325583338737488, "2079": 0.11081436276435852, "2090": 0.5584990978240967, "2099": 0.4709797203540802, "2105": 0... | 4928282 | &NA; Immune cells communicate by exchanging cytokines to achieve a context‐appropriate response, but the distances over which such communication happens are not known. Here, we used theoretical considerations and experimental models of immune responses in vitro and in vivo to quantify the spatial extent of cytokine com... | A Tunable Diffusion‐Consumption Mechanism of Cytokine Propagation Enables Plasticity in Cell‐to‐Cell Communication in the Immune System |
{"1011": 0.011650617234408855, "1017": 0.06886265426874161, "1049": 0.5080875158309937, "1996": 0.3676496744155884, "1998": 0.04860413447022438, "1999": 0.012615402229130268, "2003": 0.15943801403045654, "2004": 0.10203468054533005, "2005": 0.3241194784641266, "2012": 0.28670501708984375, "2013": 0.3416208028793335, "2... | 4932668 | In birds and mammals, cardiac neural crest is essential for heart development and contributes to conotruncal cushion formation and outflow tract septation. The zebrafish prototypical heart lacks outflow tract septation, raising the question of whether cardiac neural crest exists in zebrafish. Here, results from three d... | Cardiac neural crest contributes to cardiomyogenesis in zebrafish. |
{"1011": 0.1477125883102417, "1051": 0.022212404757738113, "2000": 0.29255300760269165, "2005": 0.21372433006763458, "2013": 0.09406650811433792, "2039": 0.2409527748823166, "2046": 0.018384648486971855, "2064": 0.3897167444229126, "2071": 0.06795065850019455, "2076": 0.013579257763922215, "2077": 0.10379679501056671, ... | 4939312 | The ability to increase pH is a crucial need for desalination pretreatment (especially in reverse osmosis) and for other industries, but processes used to raise pH often incur significant emissions and nonrenewable resource use. Alternatively, waste brine from desalination can be used to create sodium hydroxide, via ap... | Sodium Hydroxide Production from Seawater Desalination Brine: Process Design and Energy Efficiency. |
{"1011": 0.3012613356113434, "1038": 0.38308101892471313, "1173": 0.41647201776504517, "2000": 0.09938567131757736, "2003": 0.040196798741817474, "2004": 0.16607704758644104, "2005": 0.0009760859538801014, "2013": 0.025073638185858727, "2015": 0.0009760859538801014, "2020": 0.09672962874174118, "2022": 0.02030035853385... | 4942718 | The differentiation of the bacterium Bacillus subtilis into a dormant spore is among the most well-characterized developmental pathways in biology. Classical genetic screens performed over the past half century identified scores of factors involved in every step of this morphological process. More recently, transcripti... | High-Throughput Genetic Screens Identify a Large and Diverse Collection of New Sporulation Genes in Bacillus subtilis |
{"1011": 0.27934664487838745, "1044": 0.151916041970253, "2015": 0.043007105588912964, "2042": 0.1384023278951645, "2050": 0.8600510358810425, "2064": 0.07341018319129944, "2075": 1.059443712234497, "2091": 0.010684899985790253, "2098": 0.36426326632499695, "2101": 0.22937409579753876, "2111": 0.06795065850019455, "216... | 4951831 | Discovering the stress-buffering effects of social relationships has been one of the major findings in psychobiology in the last century. However, an understanding of the underlying neurobiological and psychological mechanisms of this buffering is only beginning to emerge. An important avenue of this research concerns ... | Psychobiological mechanisms underlying the social buffering of the hypothalamic-pituitary-adrenocortical axis: a review of animal models and human studies across development. |
{"1040": 0.2539152204990387, "1047": 0.9531047344207764, "1052": 0.4158279001712799, "2007": 0.1734936386346817, "2015": 0.3070250153541565, "2039": 0.04860413447022438, "2042": 0.01934296265244484, "2043": 0.12038381397724152, "2046": 0.42353010177612305, "2050": 0.4938860833644867, "2051": 0.010684899985790253, "2060... | 4959368 | Most patients with pancreatic ductal adenocarcinoma (PDAC) are diagnosed with advanced disease and survive less than 12 months. PDAC has been linked with obesity and glucose intolerance, but whether changes in circulating metabolites are associated with early cancer progression is unknown. To better understand metaboli... | Elevation of circulating branched-chain amino acids is an early event in human pancreatic adenocarcinoma development |
{"1011": 0.25694093108177185, "1017": 0.5483922958374023, "1041": 0.0038986403960734606, "1044": 0.14602625370025635, "1047": 0.983511209487915, "1050": 0.5920094847679138, "1052": 0.9209672808647156, "2002": 0.6322478652000427, "2006": 0.22157983481884003, "2007": 0.3897167444229126, "2008": 0.20660123229026794, "2011... | 4961038 | Somatic mutations that activate phosphoinositide 3-kinase (PI3K) have been identified in the p110-alpha catalytic subunit (encoded by PIK3CA). They are most frequently observed in two hotspots: the helical domain (E545K and E542K) and the kinase domain (H1047R). Although the p110-alpha mutants are transforming in vitro... | Effective Use of PI3K and MEK Inhibitors to Treat Mutant K-Ras G12D and PIK3CA H1047R Murine Lung Cancers |
{"1009": 0.3353555500507355, "1011": 0.07884006202220917, "1043": 1.0560526847839355, "1052": 0.2837681770324707, "1058": 0.08782484382390976, "1060": 0.5045560002326965, "2003": 0.2516399025917053, "2006": 0.1889725625514984, "2007": 0.0752234235405922, "2011": 0.036437395960092545, "2013": 0.10203468054533005, "2015"... | 4979184 | Glioblastoma (GBM) is the most malignant brain tumor and is highly resistant to intensive combination therapies and anti-VEGF therapies. To assess the resistance mechanism to anti-VEGF therapy, we examined the vessels of GBMs in tumors that were induced by the transduction of p53(+/-) heterozygous mice with lentiviral ... | Transdifferentiation of glioblastoma cells into vascular endothelial cells. |
{"1011": 0.058784693479537964, "1039": 0.7028654217720032, "1044": 0.09406650811433792, "1045": 0.4512746334075928, "1054": 0.38041436672210693, "1060": 0.6286086440086365, "2004": 0.0009760859538801014, "2007": 0.503966212272644, "2010": 0.8057082891464233, "2011": 0.21922965347766876, "2012": 1.0802149772644043, "202... | 4993011 | ATRX (alpha thalassemia/mental retardation X-linked) complexes with DAXX to deposit histone variant H3.3 into repetitive heterochromatin. Recent genome sequencing studies in cancers have revealed mutations in ATRX and their association with ALT (alternative lengthening of telomeres) activation. Here we report depletion... | Ribosomal DNA copy loss and repeat instability in ATRX-mutated cancers |
{"1013": 0.015504186972975731, "1041": 0.39367714524269104, "1043": 0.05970508232712746, "1045": 0.011650617234408855, "1052": 0.29981520771980286, "1998": 0.0913962796330452, "2000": 0.2786078155040741, "2003": 0.09584271162748337, "2004": 0.11430477350950241, "2005": 0.3743882179260254, "2007": 0.27044451236724854, "... | 4999387 | Insecticide-treated nets (ITNs) and indoor residual spraying (IRS) are currently the preferred methods of malaria vector control. In many cases, these methods are used together in the same households, especially to suppress transmission in holoendemic and hyperendemic scenarios. Though widespread, there has been limite... | Combining indoor residual spraying and insecticide-treated nets for malaria control in Africa: a review of possible outcomes and an outline of suggestions for the future |
{"1011": 0.13755162060260773, "1013": 0.07159364968538284, "1018": 0.1477125883102417, "1021": 0.5662899017333984, "1022": 0.23015019297599792, "1041": 1.0655186176300049, "1044": 0.26446542143821716, "1048": 0.15860503911972046, "1155": 0.38308101892471313, "1999": 0.029824240133166313, "2005": 0.11081436276435852, "2... | 4999633 | 17β-estradiol (E2) can rapidly induce cAMP production, but the conditions under which these cAMP levels are best measured and the signaling pathways responsible for the consequent proliferative effects on breast cancer cells are not fully understood. To help resolve these issues, we compared cAMP mechanistic responses ... | Membrane estrogen receptor-α levels in MCF-7 breast cancer cells predict cAMP and proliferation responses |
{"1039": 0.0770333781838417, "1041": 0.22392450273036957, "1062": 0.672426164150238, "1996": 0.30486753582954407, "1997": 0.06429435312747955, "2011": 0.2447827309370041, "2013": 0.42225050926208496, "2014": 0.7426811456680298, "2015": 0.2576959431171417, "2029": 0.11691460013389587, "2033": 0.6823468804359436, "2038":... | 5002665 | The embryonic cell lineage of Caenorhabditis elegans has been traced from zygote to newly hatched larva, with the result that the entire cell lineage of this organism is now known. During embryogenesis 671 cells are generated; in the hermaphrodite 113 of these (in the male 111) undergo programmed death and the remainde... | The embryonic cell lineage of the nematode Caenorhabditis elegans. |
{"1011": 0.13157635927200317, "1038": 1.0285027027130127, "1039": 0.0752234235405922, "1043": 0.960606575012207, "1048": 0.5255602598190308, "1056": 0.5104349255561829, "2011": 0.347847044467926, "2029": 0.12986256182193756, "2046": 0.15442965924739838, "2061": 0.672426164150238, "2064": 0.23787821829319, "2076": 0.274... | 5003144 | Maintenance of immunological self-tolerance requires lymphocytes carrying self-reactive antigen receptors to be selectively prevented from mounting destructive or inflammatory effector responses. Classically, self-tolerance is viewed in terms of the removal, editing, or silencing of B and T cells that have formed self-... | Self-Reactive B Cells in the Germinal Center Reaction. |
{"1999": 0.8853482007980347, "2001": 0.011650617234408855, "2003": 0.26446542143821716, "2035": 0.30989447236061096, "2043": 0.0797421783208847, "2054": 0.32129061222076416, "2055": 0.043007105588912964, "2057": 0.09050461649894714, "2075": 0.0770333781838417, "2087": 0.004870930220931768, "2098": 0.036437395960092545,... | 5035827 | Human aging is characterized by a chronic, low-grade inflammation, and this phenomenon has been termed as "inflammaging. " Inflammaging is a highly significant risk factor for both morbidity and mortality in the elderly people, as most if not all age-related diseases share an inflammatory pathogenesis. Nevertheless, th... | Chronic inflammation (inflammaging) and its potential contribution to age-associated diseases. |
{"1011": 0.12728634476661682, "1996": 0.1221139207482338, "1999": 0.10379679501056671, "2003": 0.3409265875816345, "2008": 0.2659635543823242, "2011": 0.011650617234408855, "2024": 0.5092619061470032, "2029": 0.41840189695358276, "2063": 0.42225050926208496, "2073": 0.21214580535888672, "2076": 0.09850110858678818, "20... | 5035851 | Cryptochromes are flavin-containing blue light photoreceptors related to photolyases-they are found in both plants and animals and have recently been described for bacteria. In plants, cryptochromes perform a variety of functions including the entrainment of circadian rhythms. They serve a similar role in Drosophila an... | Cryptochromes Enabling Plants and Animals to Determine Circadian Time |
{"1011": 0.2918238639831543, "1014": 0.5718178153038025, "1015": 0.20977331697940826, "1038": 0.6960725784301758, "1050": 0.04113444685935974, "1999": 0.22937409579753876, "2006": 0.1889725625514984, "2011": 0.0606246218085289, "2012": 0.15359249711036682, "2013": 0.49626702070236206, "2015": 0.5957841277122498, "2020"... | 5085118 | OBJECTIVE We recently demonstrated that primitive neural crest-derived (NC) cells migrate from the cardiac neural crest during embryonic development and remain in the heart as dormant stem cells, with the capacity to differentiate into various cell types, including cardiomyocytes. Here, we examined the migration and di... | Neural crest-derived stem cells migrate and differentiate into cardiomyocytes after myocardial infarction. |
{"1009": 1.0628231763839722, "1039": 0.35334911942481995, "1996": 0.16276304423809052, "1999": 0.35403475165367126, "2005": 0.0029254043474793434, "2011": 0.175953671336174, "2029": 0.27712854743003845, "2038": 0.0009760859538801014, "2039": 0.7105726003646851, "2042": 0.0058422754518687725, "2046": 0.01261540222913026... | 5094468 | During the past two decades calcium (Ca2+) accumulation in energized mitochondria has emerged as a biological process of utmost physiological relevance. Mitochondrial Ca2+ uptake was shown to control intracellular Ca2+ signalling, cell metabolism, cell survival and other cell-type specific functions by buffering cytoso... | Mitochondria as sensors and regulators of calcium signalling |
{"1011": 0.39696553349494934, "1015": 0.5116065740585327, "1018": 0.4909018874168396, "1019": 0.2954642176628113, "1048": 0.6027565002441406, "1052": 0.6522845029830933, "1996": 0.26146242022514343, "1999": 0.9717550277709961, "2003": 0.1734936386346817, "2007": 0.02792670577764511, "2008": 0.09495500475168228, "2011":... | 5099266 | Inflammasomes are multiprotein complexes that include members of the NLR (nucleotide-binding domain leucine-rich repeat containing) family and caspase-1. Once bacterial molecules are sensed within the macrophage, the inflammasome is assembled, mediating the activation of caspase-1. Caspase-11 mediates caspase-1 activat... | Caspase-11 promotes the fusion of phagosomes harboring pathogenic bacteria with lysosomes by modulating actin polymerization. |
{"1996": 0.0038986403960734606, "1999": 0.08782484382390976, "2002": 0.7809720039367676, "2003": 0.012615402229130268, "2005": 0.11081436276435852, "2029": 0.05786345899105072, "2046": 0.20022670924663544, "2058": 0.026025565341114998, "2076": 0.011650617234408855, "2079": 0.18411032855510712, "2080": 0.055094651877880... | 5106691 | Chronic inflammation constitutes an important link between obesity and its pathophysiological sequelae. In contrast to the belief that inflammatory signals exert a fundamentally negative impact on metabolism, we show that proinflammatory signaling in the adipocyte is in fact required for proper adipose tissue remodelin... | Adipocyte inflammation is essential for healthy adipose tissue expansion and remodeling. |
{"1039": 0.5833279490470886, "1043": 0.304147332906723, "1044": 0.3409265875816345, "1156": 0.5341835021972656, "1998": 0.03266380727291107, "2002": 0.07884006202220917, "2007": 0.02412080205976963, "2012": 0.6892333030700684, "2026": 0.5584990978240967, "2029": 0.10379679501056671, "2076": 0.12642613053321838, "2080":... | 5107861 | Exposure to psychosocial stress is a risk factor for many diseases, including atherosclerosis. Although incompletely understood, interaction between the psyche and the immune system provides one potential mechanism linking stress and disease inception and progression. Known cross-talk between the brain and immune syste... | Chronic variable stress activates hematopoietic stem cells |
{"1011": 0.06977381557226181, "1020": 0.2837681770324707, "1039": 0.21135559678077698, "1044": 0.15023678541183472, "2002": 0.5662899017333984, "2003": 0.15442965924739838, "2005": 0.09938567131757736, "2011": 0.22937409579753876, "2029": 0.12038381397724152, "2058": 0.006812678650021553, "2079": 0.3262358605861664, "2... | 5108807 | Ciliary neurotrophic factor (CNTF) induces weight loss and improves glucose tolerance in humans and rodents. CNTF is thought to act centrally by inducing hypothalamic neurogenesis to modulate food intake and peripherally by altering hepatic gene expression, in a manner similar to that of leptin. Here, we show that CNTF... | CNTF reverses obesity-induced insulin resistance by activating skeletal muscle AMPK |
{"1015": 0.5381823778152466, "1019": 0.2231435477733612, "1039": 1.0512858629226685, "1041": 0.06795065850019455, "1044": 0.7510106563568115, "1058": 0.07068414986133575, "2001": 0.3956514894962311, "2002": 1.2916187047958374, "2010": 0.4487839937210083, "2013": 0.6254787445068359, "2020": 0.07159364968538284, "2028": ... | 5114282 | BACKGROUND Hepatitis C virus (HCV) is estimated to affect 130-180 million people worldwide. Although its origin is unknown, patterns of viral diversity suggest that HCV genotype 1 probably originated from West Africa. Previous attempts to estimate the spatiotemporal parameters of the virus, both globally and regionally... | The Global Spread of Hepatitis C Virus 1a and 1b: A Phylodynamic and Phylogeographic Analysis |
{"1020": 0.29473719000816345, "1998": 0.04860413447022438, "2005": 0.23864774405956268, "2007": 0.3824150264263153, "2015": 0.09317722171545029, "2033": 0.5957841277122498, "2041": 0.12986256182193756, "2042": 0.2696990668773651, "2045": 0.3106105625629425, "2057": 0.083342544734478, "2060": 0.45870962738990784, "2064"... | 5114940 | BACKGROUND Smoking is the leading preventable cause of illness and premature death worldwide. Some medications have been proven to help people to quit, with three licensed for this purpose in Europe and the USA: nicotine replacement therapy (NRT), bupropion, and varenicline. Cytisine (a treatment pharmacologically simi... | Pharmacological interventions for smoking cessation: an overview and network meta-analysis. |
{"1011": 0.29255300760269165, "1017": 0.417115718126297, "1039": 0.7473171949386597, "1043": 0.11343330889940262, "1054": 0.1064341589808464, "1997": 0.1011524572968483, "2003": 0.06795065850019455, "2011": 0.24631060659885406, "2012": 0.12038381397724152, "2029": 0.2622140049934387, "2116": 0.38174858689308167, "2179"... | 5116145 | The sequence specificity of DNA-binding proteins is the primary mechanism by which the cell recognizes genomic features. Here, we describe systematic determination of yeast transcription factor DNA-binding specificities. We obtained binding specificities for 112 DNA-binding proteins representing 19 distinct structural ... | A library of yeast transcription factor motifs reveals a widespread function for Rsc3 in targeting nucleosome exclusion at promoters. |
{"1017": 0.5751199722290039, "1041": 0.18004031479358673, "1043": 0.7445381283760071, "1047": 0.21922965347766876, "2004": 0.055094651877880096, "2005": 0.03925827145576477, "2011": 0.07431721687316895, "2029": 0.3084607720375061, "2033": 0.5882205963134766, "2058": 0.5629584193229675, "2087": 0.4374985992908478, "2091... | 5123516 | Significant endeavor has been applied to identify functional therapeutic targets in glioblastoma (GBM) to halt the growth of this aggressive cancer. We show that the receptor tyrosine kinase EphA3 is frequently overexpressed in GBM and, in particular, in the most aggressive mesenchymal subtype. Importantly, EphA3 is hi... | EphA3 maintains tumorigenicity and is a therapeutic target in glioblastoma multiforme. |
{"1011": 0.2478361576795578, "1018": 0.06795065850019455, "1023": 0.12556517124176025, "1038": 0.46363574266433716, "1039": 0.1485546976327896, "1048": 0.57457035779953, "1054": 0.1970241367816925, "1056": 0.9798521995544434, "1177": 0.12986256182193756, "2005": 0.24554696679115295, "2007": 0.2881702482700348, "2012": ... | 5132358 | Chimeric antigen receptor-modified T cells with specificity for CD19 have shown promise in the treatment of chronic lymphocytic leukemia (CLL). It remains to be established whether chimeric antigen receptor T cells have clinical activity in acute lymphoblastic leukemia (ALL). Two children with relapsed and refractory p... | Chimeric antigen receptor-modified T cells for acute lymphoid leukemia. |
{"1011": 0.19862671196460724, "1041": 0.7647408246994019, "1042": 0.25088030099868774, "2003": 0.29473719000816345, "2005": 0.0019512200960889459, "2015": 0.7333439588546753, "2020": 0.06337817758321762, "2024": 0.35677260160446167, "2075": 0.1011524572968483, "2109": 0.22626367211341858, "2224": 0.0770333781838417, "2... | 5132461 | Extended-connectivity fingerprints (ECFPs) are a novel class of topological fingerprints for molecular characterization. Historically, topological fingerprints were developed for substructure and similarity searching. ECFPs were developed specifically for structure-activity modeling. ECFPs are circular fingerprints wit... | Extended-connectivity fingerprints. |
{"1011": 0.3622259199619293, "1015": 0.6764062643051147, "1017": 0.4974553883075714, "1050": 0.272677481174469, "2004": 0.09672962874174118, "2007": 0.0797421783208847, "2011": 0.3423145115375519, "2012": 0.2026219218969345, "2015": 0.6275664567947388, "2018": 0.6960725784301758, "2028": 0.23710809648036957, "2029": 0.... | 5137019 | HIV-1 replication within macrophages of the CNS often results in cognitive and motor impairment, which is known as HIV-associated dementia (HAD) in its most severe form. IFN-beta suppresses viral replication within these cells during early CNS infection, but the effect is transient. HIV-1 eventually overcomes this prot... | Suppressor of cytokine signaling 3 inhibits antiviral IFN-beta signaling to enhance HIV-1 replication in macrophages. |
{"1011": 0.07884006202220917, "1055": 0.1602703034877777, "1996": 0.49864232540130615, "1997": 0.1332872211933136, "1999": 0.004870930220931768, "2015": 0.6186635494232178, "2029": 0.21687394380569458, "2033": 0.43244171142578125, "2076": 0.052318159490823746, "2079": 0.3877306580543518, "2109": 0.2881702482700348, "21... | 5144381 | The 26S proteasome plays a fundamental role in eukaryotic homeostasis by undertaking the highly controlled degradation of a wide range of proteins, including key cellular regulators such as those controlling cell-cycle progression and apoptosis. Here we report the structure of the human 26S proteasome determined by cry... | Molecular model of the human 26S proteasome. |
{"1013": 0.1602703034877777, "1017": 0.043007105588912964, "1018": 0.0354953333735466, "1037": 0.46424978971481323, "1038": 0.34508460760116577, "1041": 0.20022670924663544, "1042": 0.5461324453353882, "1048": 0.15359249711036682, "1051": 0.6527929902076721, "1052": 0.0752234235405922, "1085": 0.30989447236061096, "201... | 5145974 | STUDY QUESTION In women undergoing IVF, are urinary bisphenol A (BPA) concentrations associated with ovarian response and early reproductive outcomes, including oocyte maturation and fertilization, Day 3 embryo quality and blastocyst formation? SUMMARY ANSWER Higher urinary BPA concentrations were found to be associate... | Urinary bisphenol A concentrations and early reproductive health outcomes among women undergoing IVF. |
{"1014": 0.34715715050697327, "1044": 0.8117979168891907, "1053": 0.05694137513637543, "1069": 0.32553088665008545, "1998": 0.09406650811433792, "2000": 0.08603433519601822, "2001": 0.020300358533859253, "2021": 0.014542185701429844, "2035": 0.09672962874174118, "2042": 0.053244512528181076, "2044": 0.10555581003427505... | 5151024 | BACKGROUND The diagnosis of hypertension has traditionally been based on blood-pressure measurements in the clinic, but home and ambulatory measurements better correlate with cardiovascular outcome, and ambulatory monitoring is more accurate than both clinic and home monitoring in diagnosing hypertension. We aimed to c... | Cost-effectiveness of options for the diagnosis of high blood pressure in primary care: a modelling study. |
{"1018": 0.03266380727291107, "1019": 0.1905880719423294, "1020": 0.3248254358768463, "1022": 0.0797421783208847, "1023": 0.05694137513637543, "1042": 0.969535231590271, "1052": 0.3601844012737274, "2005": 0.29255300760269165, "2007": 0.15275461971759796, "2011": 0.10291612148284912, "2012": 0.1930064558982849, "2029":... | 5152028 | BACKGROUND Homocysteine is a risk factor for coronary artery disease (CAD), although a causal relation remains to be proven. The importance of determining direct causality rests in the fact that plasma homocysteine can be safely and inexpensively reduced by 25% with folic acid. This reduction is maximally achieved by d... | Folic acid improves endothelial function in coronary artery disease via mechanisms largely independent of homocysteine lowering. |
{"1011": 0.22079704701900482, "1015": 0.4132472574710846, "1042": 0.7201237678527832, "2003": 0.21687394380569458, "2004": 0.5914691090583801, "2011": 0.45623743534088135, "2012": 0.29981520771980286, "2028": 0.011650617234408855, "2029": 0.12986256182193756, "2033": 0.6139179468154907, "2044": 0.6613984704017639, "206... | 5172048 | Exuberant fibroproliferation is a common complication after injury for reasons that are not well understood. One key component of wound repair that is often overlooked is mechanical force, which regulates cell-matrix interactions through intracellular focal adhesion components, including focal adhesion kinase (FAK). He... | Focal adhesion kinase links mechanical force to skin fibrosis via inflammatory signaling |
{"1011": 0.42990362644195557, "1014": 0.49030399322509766, "1017": 0.9100211262702942, "1053": 0.8281423449516296, "2001": 0.09672962874174118, "2007": 0.055094651877880096, "2015": 0.7009293437004089, "2020": 0.02316705882549286, "2051": 0.09406650811433792, "2080": 0.18816383183002472, "2084": 0.08244366943836212, "2... | 5185871 | Importance The Sepsis-3 Criteria emphasized the value of a change of 2 or more points in the Sequential [Sepsis-related] Organ Failure Assessment (SOFA) score, introduced quick SOFA (qSOFA), and removed the systemic inflammatory response syndrome (SIRS) criteria from the sepsis definition. Objective Externally validate... | Prognostic Accuracy of the SOFA Score, SIRS Criteria, and qSOFA Score for In-Hospital Mortality Among Adults With Suspected Infection Admitted to the Intensive Care Unit |
{"1003": 0.25995752215385437, "1049": 0.04487626627087593, "1998": 0.11343330889940262, "2012": 0.2478361576795578, "2043": 0.14433705806732178, "2044": 0.28670501708984375, "2052": 0.018384648486971855, "2053": 0.20580662786960602, "2064": 0.1693800985813141, "2065": 0.015504186972975731, "2075": 0.28450319170951843, ... | 5222182 | Understanding which factors influence mammographically dense and nondense areas is important because percent mammographic density adjusted for age is a strong, continuously distributed risk factor for breast cancer, especially when adjusted for weight or body mass index. Using computer-assisted methods, we measured mam... | Predictors of mammographic density: insights gained from a novel regression analysis of a twin study. |
{"1011": 0.1677299439907074, "1041": 0.8366385698318481, "1998": 0.4855078160762787, "2006": 0.5010119676589966, "2007": 0.2837681770324707, "2011": 0.1685553640127182, "2038": 0.09584271162748337, "2048": 0.07068414986133575, "2051": 0.27712854743003845, "2058": 0.10379679501056671, "2064": 0.25467249751091003, "2071"... | 5223817 | Each cell division requires the unwinding of millions of DNA base pairs to allow chromosome duplication and gene transcription. As DNA replication and transcription share the same template, conflicts between both processes are unavoidable and head-on collisions are thought to be particularly problematic. Surprisingly, ... | Shaping the landscape of the Escherichia coli chromosome: replication-transcription encounters in cells with an ectopic replication origin |
{"1011": 0.4764525294303894, "1013": 0.16524957120418549, "1516": 0.007782140281051397, "1996": 0.1510767638683319, "1998": 0.3077431619167328, "2025": 0.012615402229130268, "2029": 0.1384023278951645, "2033": 0.9379299283027649, "2046": 0.3560888469219208, "2052": 0.5324648022651672, "2053": 0.04487626627087593, "2062... | 5236443 | Without epithelial–mesenchymal transitions, in which polarized epithelial cells are converted into motile cells, multicellular organisms would be incapable of getting past the blastula stage of embryonic development. However, this important developmental programme has a more sinister role in tumour progression. Epithel... | Epithelial–mesenchymal transitions in tumour progression |
{"1037": 0.11081436276435852, "1996": 0.026025565341114998, "2002": 0.1930064558982849, "2004": 0.026025565341114998, "2005": 0.021256839856505394, "2013": 0.2983669638633728, "2031": 0.00875066313892603, "2033": 0.46670228242874146, "2038": 0.021256839856505394, "2042": 0.05046287178993225, "2049": 0.22937409579753876... | 5238341 | Although once primarily recognized for its roles in hemostasis and thrombosis, the platelet has been increasingly recognized as a multipurpose cell. Indeed, circulating platelets have the ability to influence a wide range of seemingly unrelated pathophysiologic events. Here, we highlight some of the notable observation... | Platelets at the interface of thrombosis, inflammation, and cancer. |
{"2002": 0.5267143249511719, "2003": 0.38174858689308167, "2005": 0.05139094591140747, "2008": 0.23633737862110138, "2011": 0.10555581003427505, "2015": 0.4349733293056488, "2024": 0.5086748600006104, "2029": 0.25995752215385437, "2060": 0.13670019805431366, "2064": 0.31845372915267944, "2076": 0.058784693479537964, "2... | 5252837 | DNA topoisomerases are the magicians of the DNA world — by allowing DNA strands or double helices to pass through each other, they can solve all of the topological problems of DNA in replication, transcription and other cellular transactions. Extensive biochemical and structural studies over the past three decades have... | Cellular roles of DNA topoisomerases: a molecular perspective |
{"1037": 0.0058422754518687725, "2001": 0.08961215615272522, "2003": 0.15359249711036682, "2005": 0.026025565341114998, "2008": 0.010684899985790253, "2013": 0.3423145115375519, "2015": 0.23556606471538544, "2024": 0.1477125883102417, "2029": 0.09761575609445572, "2043": 0.10993985831737518, "2064": 0.16110190749168396... | 5253987 | The microRNA (miRNA) "sponge" method was introduced three years ago as a means to create continuous miRNA loss of function in cell lines and transgenic organisms. Sponge RNAs contain complementary binding sites to a miRNA of interest, and are produced from transgenes within cells. As with most miRNA target genes, a spo... | MicroRNA sponges: progress and possibilities. |
{"1011": 0.06612417846918106, "1015": 0.3601844012737274, "1052": 0.6369074583053589, "1059": 0.3903779089450836, "2008": 0.014542185701429844, "2011": 0.23247487843036652, "2028": 0.08244366943836212, "2029": 0.29981520771980286, "2046": 0.3683255612850189, "2079": 0.0797421783208847, "2106": 0.15442965924739838, "216... | 5254463 | Colorectal cancer is one of the major causes of cancer-related deaths. To gain further insights into the mechanisms underlying its development, we investigated the role of Wip1 phosphatase, which is highly expressed in intestinal stem cells, in the mouse model of APC(Min)-driven polyposis. We found that Wip1 removal in... | Wip1 phosphatase regulates p53-dependent apoptosis of stem cells and tumorigenesis in the mouse intestine. |
{"2000": 0.0842406153678894, "2003": 0.09317722171545029, "2064": 0.06154331564903259, "2079": 0.10555581003427505, "2089": 0.040196798741817474, "2114": 0.029824240133166313, "2129": 0.1011524572968483, "2334": 0.23710809648036957, "2339": 0.3304552733898163, "2389": 0.28670501708984375, "2401": 0.14433705806732178, "... | 5254741 | Networks of blood vessels in normal and tumour tissues have heterogeneous structures, with widely varying blood flow pathway lengths. To achieve efficient blood flow distribution, mechanisms for the structural adaptation of vessel diameters must be able to inhibit the formation of functional shunts (whereby short pathw... | The shunt problem: control of functional shunting in normal and tumour vasculature |
{"1011": 0.3923587501049042, "1043": 0.9805850982666016, "1058": 0.8666408061981201, "1999": 0.021256839856505394, "2003": 0.15359249711036682, "2004": 0.7755908370018005, "2005": 0.3910386264324188, "2006": 0.3269403576850891, "2011": 0.1734936386346817, "2029": 0.06429435312747955, "2034": 0.1602703034877777, "2038":... | 5256564 | The unique metabolic demands of cancer cells underscore potentially fruitful opportunities for drug discovery in the era of precision medicine. However, therapeutic targeting of cancer metabolism has led to surprisingly few new drugs to date. The neutral amino acid glutamine serves as a key intermediate in numerous met... | Pharmacological Blockade of ASCT2-dependent Glutamine Transport Leads To Anti-tumor Efficacy in Preclinical Models |
{"1037": 0.7067264318466187, "1039": 0.151916041970253, "1156": 0.6149744987487793, "1999": 0.14179791510105133, "2004": 0.03925827145576477, "2005": 0.3084607720375061, "2007": 0.12728634476661682, "2011": 0.05046287178993225, "2029": 0.2990913391113281, "2076": 0.3012613356113434, "2080": 0.03831886500120163, "2091":... | 5260382 | Serotonin signaling suppresses generation of amyloid-β (Aβ) in vitro and in animal models of Alzheimer’s disease (AD). We show that in an aged transgenic AD mouse model (APP/PS1 plaque-bearing mice), the antidepressant citalopram, a selective serotonin reuptake inhibitor, decreased Aβ in brain interstitial fluid in a d... | An Antidepressant Decreases CSF Aβ Production in Healthy Individuals and in Transgenic AD Mice |
{"1013": 0.06703783571720123, "1014": 0.1718502640724182, "1015": 0.7295845746994019, "1019": 0.14939609169960022, "1038": 0.4248080551624298, "1039": 0.7445381283760071, "1043": 0.5685047507286072, "1044": 0.8583967685699463, "1045": 0.13243216276168823, "1052": 0.2696990668773651, "1081": 0.7144040465354919, "1609": ... | 5262240 | AIMS To investigate the pattern of changes in HbA1c in people with Type 1 diabetes managed by long-term Continuous subcutaneous insulin infusion. METHODS We studied HbA1c changes using computerized clinic records in 35 adult people with Type 1 diabetes and an elevated HbA1c (≥ 64 mmol/mol, 8.0%) on multiple daily insul... | Variations in the quality and sustainability of long-term glycaemic control with continuous subcutaneous insulin infusion. |
{"1997": 0.3910386264324188, "1998": 0.15610189735889435, "2001": 0.2659635543823242, "2008": 0.006812678650021553, "2011": 0.15359249711036682, "2013": 0.06703783571720123, "2020": 0.3127557039260864, "2024": 0.043007105588912964, "2029": 0.20501139760017395, "2034": 0.25467249751091003, "2038": 0.05786345899105072, "... | 5266423 | The study of thrombopoiesis has evolved greatly since an era when platelets were termed "the dust of the blood," only about 100 years ago. During this time megakaryocytes were identified as the origin of blood platelets; marrow-derived megakaryocytic progenitor cells were functionally defined and then purified; and the... | Historical review: megakaryopoiesis and thrombopoiesis. |
{"1016": 0.45994341373443604, "1040": 0.4067663550376892, "2003": 0.02887592278420925, "2004": 0.06886265426874161, "2011": 0.08244366943836212, "2013": 0.2394166737794876, "2058": 0.2160874605178833, "2063": 0.13925230503082275, "2064": 0.07068414986133575, "2079": 0.02316705882549286, "2080": 0.04207121208310127, "20... | 5268462 | Accumulating evidence indicates that obesity is closely associated with an increased risk of metabolic diseases such as insulin resistance, type 2 diabetes, dyslipidemia and nonalcoholic fatty liver disease. Obesity results from an imbalance between food intake and energy expenditure, which leads to an excessive accumu... | Obesity and Its Metabolic Complications: The Role of Adipokines and the Relationship between Obesity, Inflammation, Insulin Resistance, Dyslipidemia and Nonalcoholic Fatty Liver Disease |
{"1011": 0.3423145115375519, "1039": 0.6911921501159668, "1062": 0.16524957120418549, "2003": 0.3325583338737488, "2005": 0.2317005842924118, "2007": 0.17431432008743286, "2011": 0.1808556467294693, "2029": 0.21372433006763458, "2058": 0.4400174915790558, "2109": 0.06429435312747955, "2114": 0.12038381397724152, "2135"... | 5270265 | Trastuzumab is a successful rationally designed ERBB2-targeted therapy. However, about half of individuals with ERBB2-overexpressing breast cancer do not respond to trastuzumab-based therapies, owing to various resistance mechanisms. Clinically applicable regimens for overcoming trastuzumab resistance of different mech... | Combating trastuzumab resistance by targeting SRC, a common node downstream of multiple resistance pathways |
{"1011": 0.05139094591140747, "1999": 0.0174254160374403, "2002": 0.3877306580543518, "2003": 0.21530038118362427, "2004": 0.23710809648036957, "2005": 0.08154398202896118, "2006": 0.37371641397476196, "2008": 0.08961215615272522, "2011": 0.10818854719400406, "2015": 0.4673144817352295, "2024": 0.4425300657749176, "202... | 5271210 | MicroRNAs (miRNAs) are evolutionarily conserved small noncoding RNAs involved in the regulation of gene expression and protein translation. Many studies have shown that they play a crucial role in driving organ and tissue differentiation during embryogenesis and in the fine-tuning of fundamental biological processes, s... | MicroRNAs: new tools for diagnosis, prognosis, and therapy in hepatocellular carcinoma? |
{"1011": 0.13499516248703003, "1013": 0.034552380442619324, "1015": 0.09584271162748337, "1017": 0.021256839856505394, "1043": 0.36426326632499695, "1049": 0.23787821829319, "1054": 0.13670019805431366, "1055": 0.05694137513637543, "1056": 0.16690383851528168, "2005": 0.12556517124176025, "2007": 0.22626367211341858, "... | 5273056 | Eukaryotes have numerous checkpoint pathways to protect genome fidelity during normal cell division and in response to DNA damage. Through a screen for G2/M checkpoint regulators in zebrafish, we identified ticrr (for TopBP1-interacting, checkpoint, and replication regulator), a previously uncharacterized gene that is ... | A vertebrate gene, ticrr, is an essential checkpoint and replication regulator. |
{"1011": 0.17922431230545044, "1015": 0.0009760859538801014, "1021": 0.14686977863311768, "1038": 0.841701865196228, "1044": 0.469759464263916, "1045": 0.7248653769493103, "1047": 0.20739519596099854, "1048": 0.18573370575904846, "2004": 0.0317181795835495, "2007": 0.02887592278420925, "2008": 0.0842406153678894, "2012... | 5278233 | Loss of imprinting at IGF2, generally through an H19-independent mechanism, is associated with a large percentage of patients with the overgrowth and cancer predisposition condition Beckwith-Wiedemann syndrome (BWS). Imprinting control elements are proposed to exist within the KvLQT1 locus, because multiple BWS-associa... | A maternally methylated CpG island in KvLQT1 is associated with an antisense paternal transcript and loss of imprinting in Beckwith-Wiedemann syndrome. |
{"1003": 0.22626367211341858, "1061": 0.33675122261047363, "1181": 0.010684899985790253, "2001": 0.08961215615272522, "2013": 0.055094651877880096, "2020": 0.09761575609445572, "2026": 0.7601850032806396, "2028": 0.13414156436920166, "2034": 0.1970241367816925, "2038": 0.0038986403960734606, "2042": 0.347847044467926, ... | 5284188 | Resistance to anti-tuberculosis (TB) medicines is a major public health threat in most countries of the former Soviet Union. As no representative and quality-assured information on the magnitude of this problem existed in Belarus, a survey was conducted in the capital city of Minsk. Between November 2009 and December 2... | Alarming levels of drug-resistant tuberculosis in Belarus: results of a survey in Minsk |
{"1999": 0.2719337046146393, "2007": 0.013579257763922215, "2051": 0.6916812658309937, "2058": 0.1477125883102417, "2064": 0.32270604372024536, "2071": 0.13670019805431366, "2076": 0.03266380727291107, "2079": 0.19220098853111267, "2083": 0.8941729068756104, "2106": 0.05046287178993225, "2109": 0.09761575609445572, "21... | 5289038 | Immune clearance and resource limitation (via red blood cell depletion) shape the peaks and troughs of malaria parasitemia, which in turn affect disease severity and transmission. Quantitatively partitioning the relative roles of these effects through time is challenging. Using data from rodent malaria, we estimated th... | Partitioning regulatory mechanisms of within-host malaria dynamics using the effective propagation number. |
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