spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1044": 0.1485546976327896, "1056": 0.1685553640127182, "2001": 0.35677260160446167, "2008": 0.013579257763922215, "2009": 0.16524957120418549, "2013": 0.36426326632499695, "2020": 0.31132611632347107, "2022": 0.2493593990802765, "2025": 0.37035053968429565, "2034": 0.1873544454574585, "2038": 0.18654440343379974, "20... | 5293024 | Our attitude towards candy—“if it tastes that good, it can't be healthy”—betrays society's puritanical stance towards pleasure. Candy has been blamed for various ills, including hyperactivity in children; however, clinical trials have not supported this.1 Candy—sugar confectionery and chocolate—is not a recent inventi... | Life is sweet: candy consumption and longevity. |
{"1011": 0.11517547070980072, "1020": 0.34508460760116577, "1053": 0.8633513450622559, "1055": 0.5827828645706177, "2007": 0.19541899859905243, "2008": 0.018384648486971855, "2011": 0.3339579105377197, "2013": 0.26146242022514343, "2015": 0.1685553640127182, "2020": 0.14602625370025635, "2029": 0.1946154683828354, "205... | 5304891 | Little is known about the inter-individual variation of cytokine responses to different pathogens in healthy individuals. To systematically describe cytokine responses elicited by distinct pathogens and to determine the effect of genetic variation on cytokine production, we profiled cytokines produced by peripheral blo... | Inter-individual variability and genetic influences on cytokine responses to bacteria and fungi |
{"1011": 0.026976587250828743, "1047": 0.10555581003427505, "1052": 0.34023189544677734, "1055": 0.3464667797088623, "1156": 0.32270604372024536, "2007": 0.05694137513637543, "2011": 0.4196864068508148, "2029": 0.27044451236724854, "2050": 0.29255300760269165, "2064": 0.2231435477733612, "2076": 0.15693697333335876, "2... | 5321708 | Cytokinesis is the final stage in cell division. Although integrins can regulate cytokinesis, the mechanisms involved are not fully understood. In this study, we demonstrate that integrin-regulated ERK (extracellular signal-related kinase) and RSK (p90 ribosomal S6 kinase) signaling promotes successful cytokinesis. Inh... | Integrins promote cytokinesis through the RSK signaling axis. |
{"1009": 0.1930064558982849, "1014": 0.19782574474811554, "1020": 0.3283478021621704, "1026": 0.040196798741817474, "1044": 0.3464667797088623, "1050": 0.7710843086242676, "1052": 0.5069117546081543, "1055": 0.53589928150177, "2007": 0.034552380442619324, "2015": 0.32270604372024536, "2022": 0.06246116757392883, "2029"... | 5323845 | BACKGROUND Direct recordings from peripheral sympathetic nerves have shown an increased sympathetic drive in pregnancy-induced hypertension (PIH) and preeclampsia (PE). It is unknown whether sympathetic drive is altered in normal pregnancy, when arterial blood pressure can be normal or relatively low. The aim of this s... | Sympathetic neural mechanisms in normal and hypertensive pregnancy in humans. |
{"1018": 0.24631060659885406, "1049": 0.01934296265244484, "2000": 0.3381449282169342, "2014": 0.09938567131757736, "2020": 0.00875066313892603, "2055": 0.00875066313892603, "2062": 0.04207121208310127, "2064": 0.06977381557226181, "2071": 0.2561853528022766, "2093": 0.27712854743003845, "2111": 0.1011524572968483, "21... | 5339554 | This qualitative study identified barriers to African American women's participation in a community-based behavioral intervention trial to increase mammography screening. Four themes emerged from focus group discussions with community agency providers and research team members. These themes were (1) going to the gateke... | Barriers to recruiting urban African American women into research studies in community settings. |
{"1023": 0.1358480453491211, "1051": 0.3170322775840759, "1053": 0.151916041970253, "1998": 0.25845035910606384, "2001": 0.22937409579753876, "2004": 0.2447827309370041, "2007": 0.17020416259765625, "2012": 0.791648268699646, "2013": 0.12642613053321838, "2020": 0.11343330889940262, "2022": 0.20501139760017395, "2042":... | 5372432 | BACKGROUND There is some previous evidence that diagnosis of cancer at death, recorded as registry death certificate only records, is associated with problems of access to care. METHODS Records from the Northern and Yorkshire Cancer Registry for patients registered with breast, colorectal, lung, ovarian or prostate can... | Geographical access to healthcare in Northern England and post-mortem diagnosis of cancer. |
{"1011": 0.3304552733898163, "1044": 0.520350456237793, "1045": 0.29109421372413635, "1049": 0.259204238653183, "2002": 0.20022670924663544, "2006": 0.06977381557226181, "2008": 0.07431721687316895, "2011": 0.32553088665008545, "2012": 0.026976587250828743, "2026": 0.5990082025527954, "2029": 0.35060185194015503, "2038... | 5372773 | Human cytomegalovirus (HCMV) expresses several homologues of human interleukin 10 (hIL-10) possessing immunomodulatory properties which may promote viral infection by modulating the function of myeloid cells. We examined the phenotype and phagocytic capability of human monocytes exposed to hIL-10, an HCMV-encoded hIL-1... | Enhanced monocyte Fc phagocytosis by a homologue of interleukin-10 encoded by human cytomegalovirus. |
{"1011": 0.4400174915790558, "1039": 0.3877306580543518, "1042": 0.12814582884311676, "1996": 0.22392450273036957, "1998": 0.04394211992621422, "2015": 0.22548456490039825, "2029": 0.10379679501056671, "2050": 0.012615402229130268, "2076": 0.40871503949165344, "2079": 0.04674193635582924, "2090": 0.43938836455345154, "... | 5373138 | In this study, we describe the 3D chromosome regulatory landscape of human naive and primed embryonic stem cells. To devise this map, we identified transcriptional enhancers and insulators in these cells and placed them within the context of cohesin-associated CTCF-CTCF loops using cohesin ChIA-PET data. The CTCF-CTCF ... | 3D Chromosome Regulatory Landscape of Human Pluripotent Cells. |
{"1011": 0.1685553640127182, "1017": 0.10026945173740387, "1018": 0.12038381397724152, "1056": 0.6558387279510498, "2003": 0.04487626627087593, "2005": 0.1332872211933136, "2011": 0.2749055027961731, "2029": 0.006812678650021553, "2057": 0.17267228662967682, "2063": 0.15526613593101501, "2064": 0.28597161173820496, "20... | 5377059 | Standardization of immunophenotyping procedures has become a high priority. We have developed a suite of whole-blood, syringe-based assay systems that can be used to reproducibly assess induced innate or adaptive immune responses. By eliminating preanalytical errors associated with immune monitoring, we have defined th... | Functional analysis via standardized whole-blood stimulation systems defines the boundaries of a healthy immune response to complex stimuli. |
{"1009": 0.35813871026039124, "1015": 0.5290185213088989, "1035": 0.06612417846918106, "1038": 0.5290185213088989, "1040": 0.10291612148284912, "1048": 0.3910386264324188, "1052": 0.29255300760269165, "1056": 0.9147270321846008, "1513": 0.15943801403045654, "2007": 0.3409265875816345, "2011": 0.3560888469219208, "2012"... | 5377642 | &NA; Despite the importance of programmed cell death‐1 (PD‐1) in inhibiting T cell effector activity, the mechanisms regulating its expression remain poorly defined. We found that the chromatin organizer special AT‐rich sequence‐binding protein‐1 (Satb1) restrains PD‐1 expression induced upon T cell activation by recru... | SATB1 Expression Governs Epigenetic Repression of PD‐1 in Tumor‐Reactive T Cells |
{"1011": 0.12986256182193756, "1015": 0.19541899859905243, "1017": 0.04860413447022438, "1021": 0.02792670577764511, "1048": 0.3297532796859741, "1052": 0.6853039860725403, "1056": 0.6343214511871338, "1157": 0.5844172835350037, "1597": 0.17431432008743286, "1999": 0.4512746334075928, "2005": 0.036437395960092545, "200... | 5386514 | The therapeutic efficacy of anticancer chemotherapies may depend on dendritic cells (DCs), which present antigens from dying cancer cells to prime tumor-specific interferon-γ (IFN-γ)–producing T lymphocytes. Here we show that dying tumor cells release ATP, which then acts on P2X7 purinergic receptors from DCs and trigg... | Activation of the NLRP3 inflammasome in dendritic cells induces IL-1β–dependent adaptive immunity against tumors |
{"1011": 0.026976587250828743, "1017": 0.015504186972975731, "1022": 0.5393219590187073, "1042": 0.1619328260421753, "1043": 0.27342069149017334, "1049": 0.8091925978660583, "1155": 0.11168810725212097, "1999": 0.16442140936851501, "2004": 0.11778303235769272, "2005": 0.09050461649894714, "2008": 0.045809537172317505, ... | 5389095 | Fatty acids are integral mediators of energy storage, membrane formation and cell signaling. The pathways that orchestrate uptake of fatty acids remain incompletely understood. Expression of the integrin ligand Mfge8 is increased in human obesity and in mice on a high-fat diet, but its role in obesity is unknown. We sh... | Mfge8 promotes obesity by mediating the uptake of dietary fats and serum fatty acids |
{"1011": 0.2018241584300995, "1017": 0.01934296265244484, "1022": 0.0770333781838417, "2000": 0.12986256182193756, "2005": 0.16110190749168396, "2012": 0.42799583077430725, "2015": 0.7191727757453918, "2029": 0.09672962874174118, "2033": 0.5290185213088989, "2043": 0.0058422754518687725, "2050": 0.24631060659885406, "2... | 5389523 | Homologous recombination (HR) is necessary to counteract DNA replication stress. Common fragile site (CFS) loci are particularly sensitive to replication stress and undergo pathological rearrangements in tumors. At these loci, replication stress frequently activates DNA repair synthesis in mitosis. This mitotic DNA syn... | RAD52 Facilitates Mitotic DNA Synthesis Following Replication Stress. |
{"1043": 0.6634125709533691, "1053": 0.3241194784641266, "1999": 0.11256109178066254, "2003": 0.272677481174469, "2005": 0.3388410806655884, "2008": 0.11517547070980072, "2014": 0.6603899002075195, "2038": 0.0019512200960889459, "2042": 0.05970508232712746, "2044": 0.7898768186569214, "2047": 0.5290185213088989, "2050"... | 5395426 | Zebrafish maintain a greater capacity than mammals for central nervous system repair after injury. Understanding differences in regenerative responses between different vertebrate species may shed light on mechanisms to improve repair in humans. Quinolinic acid is an excitotoxin that has been used to induce brain injur... | Excitotoxic brain injury in adult zebrafish stimulates neurogenesis and long-distance neuronal integration. |
{"1006": 0.09228714555501938, "1009": 0.9092346429824829, "1011": 0.30917787551879883, "1015": 0.7692760229110718, "1019": 0.08154398202896118, "1038": 0.57457035779953, "1039": 0.817850649356842, "1041": 0.5827828645706177, "1042": 0.5232481360435486, "1043": 0.7746911644935608, "1045": 0.0174254160374403, "1048": 0.5... | 5398179 | HIV-1 replication is concentrated within CD4(+) T cells in B cell follicles of secondary lymphoid tissues during asymptomatic disease. Limited data suggest that a subset of T follicular helper cells (TFH) within germinal centers (GC) is highly permissive to HIV-1. Whether GC TFH are the major HIV-1 virus-producing cell... | Germinal Center T Follicular Helper Cells Are Highly Permissive to HIV-1 and Alter Their Phenotype during Virus Replication. |
{"1014": 0.4624064862728119, "1050": 0.08961215615272522, "1052": 0.2719337046146393, "1053": 0.2145126610994339, "1062": 0.16524957120418549, "2001": 0.016465263441205025, "2003": 0.014542185701429844, "2005": 0.3519764244556427, "2007": 0.06246116757392883, "2012": 0.7473171949386597, "2020": 0.16607704758644104, "20... | 5402581 | CONTEXT Atypical antipsychotic medications are widely used to treat delusions, aggression, and agitation in people with Alzheimer disease and other dementia; however, concerns have arisen about the increased risk for cerebrovascular adverse events, rapid cognitive decline, and mortality with their use. OBJECTIVE To ass... | Risk of death with atypical antipsychotic drug treatment for dementia: meta-analysis of randomized placebo-controlled trials. |
{"1011": 0.2576959431171417, "1017": 0.7473171949386597, "1047": 0.7038320899009705, "1052": 0.822151780128479, "1170": 0.029824240133166313, "2003": 0.15359249711036682, "2006": 0.3191637098789215, "2008": 0.12470348179340363, "2015": 0.3339579105377197, "2024": 0.3325583338737488, "2029": 0.23092569410800934, "2039":... | 5403286 | Phosphatidylinositol 3-kinases (PI3Ks) are crucial coordinators of intracellular signalling in response to extracellular stimuli. Hyperactivation of PI3K signalling cascades is one of the most common events in human cancers. In this Review, we discuss recent advances in our knowledge of the roles of specific PI3K isofo... | PI3K in cancer: divergent roles of isoforms, modes of activation and therapeutic targeting |
{"1009": 0.5903874635696411, "1017": 0.17431432008743286, "1041": 1.004473328590393, "1043": 0.11951763927936554, "1056": 0.5209306478500366, "2003": 0.05970508232712746, "2005": 0.11081436276435852, "2007": 0.1064341589808464, "2008": 0.016465263441205025, "2020": 0.47036975622177124, "2022": 0.38174858689308167, "202... | 5406411 | Epidermal growth factor receptor (EGFR) is known to be critically involved in tissue development and homeostasis as well as in the pathogenesis of cancer. Here we showed that Foxp3(+) regulatory T (Treg) cells express EGFR under inflammatory conditions. Stimulation with the EGF-like growth factor Amphiregulin (AREG) ma... | Amphiregulin enhances regulatory T cell-suppressive function via the epidermal growth factor receptor. |
{"1011": 0.23864774405956268, "1040": 0.13755162060260773, "1042": 0.6588751673698425, "1043": 0.5063233375549316, "1044": 0.3374483287334442, "1156": 0.7426811456680298, "1998": 0.10291612148284912, "1999": 0.11517547070980072, "2005": 0.022212404757738113, "2008": 0.007782140281051397, "2011": 0.3134697377681732, "20... | 5409325 | Pituitary gonadotropins follicle-stimulating hormone and luteinizing hormone are heterodimeric glycoproteins expressed in gonadotropes. They act on gonads and promote their development and functions including steroidogenesis and gametogenesis. Although transcriptional regulation of gonadotropin subunits has been well s... | Gonadotrope-specific deletion of Dicer results in severely suppressed gonadotropins and fertility defects. |
{"1011": 0.3547199070453644, "1015": 0.10555581003427505, "1017": 0.49626702070236206, "1044": 0.38441169261932373, "1046": 1.0001721382141113, "2007": 0.06429435312747955, "2010": 0.7408206462860107, "2029": 0.32905077934265137, "2033": 0.6848117709159851, "2046": 0.38041436672210693, "2061": 0.9194108247756958, "2070... | 5409905 | Natural interconversions between distinct somatic cell types have been reported in species as diverse as jellyfish and mice. The efficiency and reproducibility of some reprogramming events represent unexploited avenues in which to probe mechanisms that ensure robust cell conversion. We report that a conserved H3K27me3/... | Sequential histone-modifying activities determine the robustness of transdifferentiation |
{"1011": 0.15359249711036682, "1038": 0.8925741910934448, "1044": 0.10291612148284912, "1048": 0.8861536383628845, "1996": 0.11778303235769272, "2002": 0.1889725625514984, "2013": 0.052318159490823746, "2015": 0.42735910415649414, "2029": 0.10555581003427505, "2037": 0.23015019297599792, "2064": 0.1946154683828354, "20... | 5415832 | Hematopoietic stem cells (HSCs) rely on instructive cues from the bone marrow (BM) niche to maintain their quiescence and adapt blood production to the organism's needs. Alterations in the BM niche are commonly observed in blood malignancies and directly contribute to the aberrant function of disease-initiating leukemi... | Normal and leukemic stem cell niches: insights and therapeutic opportunities. |
{"1014": 0.32129061222076416, "1017": 0.13755162060260773, "1051": 0.4196864068508148, "1052": 0.45251765847206116, "1062": 0.8323994874954224, "2005": 0.034552380442619324, "2007": 0.151916041970253, "2015": 0.24325250089168549, "2021": 0.013579257763922215, "2025": 0.27934664487838745, "2050": 0.7248653769493103, "20... | 5431268 | Hypnotics are contraindicated in obstructive sleep apnoea (OSA) because of concerns of pharyngeal muscle relaxation and delayed arousal worsening hypoxaemia. However, human data are lacking. This study aimed to determine the effects of three common hypnotics on the respiratory arousal threshold, genioglossus muscle res... | Role of common hypnotics on the phenotypic causes of obstructive sleep apnoea: paradoxical effects of zolpidem. |
{"1009": 0.5540198087692261, "1014": 0.1510767638683319, "1017": 0.23556606471538544, "1052": 0.23402166366577148, "1058": 0.011650617234408855, "1609": 0.5080875158309937, "2004": 0.5517725944519043, "2005": 0.14602625370025635, "2007": 0.030771657824516296, "2012": 0.22782009840011597, "2020": 0.007782140281051397, "... | 5433667 | PURPOSE To describe the long-term (≥ 10 years) benefits of clinical human papillomavirus (HPV) DNA testing for cervical precancer and cancer risk prediction. METHODS Cervicovaginal lavages collected from 19,512 women attending a health maintenance program were retrospectively tested for HPV using a clinical test. HPV p... | Clinical human papillomavirus detection forecasts cervical cancer risk in women over 18 years of follow-up. |
{"1009": 0.2637155055999756, "1011": 0.1229778528213501, "1043": 0.0606246218085289, "1049": 0.1913948506116867, "1058": 0.11081436276435852, "2003": 0.3297532796859741, "2007": 0.08961215615272522, "2008": 0.02792670577764511, "2026": 0.5191890001296997, "2029": 0.1401015669107437, "2044": 0.05694137513637543, "2075":... | 5436081 | Dynamic membrane repair and remodelling is an elemental process that maintains cell integrity and mediates efficient cellular function. Here we report that MG53, a muscle-specific tripartite motif family protein (TRIM72), is a component of the sarcolemmal membrane-repair machinery. MG53 interacts with phosphatidylserin... | MG53 nucleates assembly of cell membrane repair machinery |
{"1014": 0.0842406153678894, "1026": 0.1485546976327896, "1048": 0.04207121208310127, "1052": 0.3177432417869568, "1055": 0.5162794589996338, "2005": 0.11691460013389587, "2007": 0.176772341132164, "2029": 0.27786844968795776, "2035": 0.2447827309370041, "2038": 0.004870930220931768, "2047": 0.41001203656196594, "2060"... | 5448119 | Genome-wide association studies have recently identified at least 15 susceptibility loci for systemic lupus erythematosus (SLE). To confirm additional risk loci, we selected SNPs from 2,466 regions that showed nominal evidence of association to SLE (P < 0.05) in a genome-wide study and genotyped them in an independent ... | A large-scale replication study identifies TNIP1, PRDM1, JAZF1, UHRF1BP1 and IL10 as risk loci for systemic lupus erythematosus |
{"1011": 0.18004031479358673, "1015": 0.1229778528213501, "1020": 0.3443928062915802, "1048": 0.16524957120418549, "1051": 0.319873183965683, "1052": 0.5860490798950195, "1055": 0.46363574266433716, "1056": 0.619189441204071, "1998": 0.06246116757392883, "2003": 0.15943801403045654, "2005": 0.007782140281051397, "2011"... | 5468807 | ARID1A, encoding a subunit of the SWI/SNF chromatin-remodelling complex, is the most frequently mutated epigenetic regulator across all human cancers. ARID1A and TP53 mutations are typically mutually exclusive. Therapeutic approaches that correlate with this genetic characteristic remain to be explored. Here, we show t... | ARID1A-mutated ovarian cancers depend on HDAC6 activity |
{"1006": 0.09761575609445572, "1011": 0.3519764244556427, "1040": 0.6070231795310974, "1048": 0.055094651877880096, "1056": 0.4093637466430664, "1518": 0.25088030099868774, "1996": 0.37907835841178894, "1997": 0.18411032855510712, "1999": 0.11430477350950241, "2003": 0.1221139207482338, "2011": 0.3622259199619293, "201... | 5473074 | The twin-arginine transport (Tat) system translocates folded proteins across the bacterial cytoplasmic or chloroplast thylakoid membrane of plants. The Tat system in most Gram-positive bacteria consists of two essential components, the TatA and TatC proteins. TatA is considered to be a bifunctional subunit, which can f... | Solution NMR structure of the TatA component of the twin-arginine protein transport system from gram-positive bacterium Bacillus subtilis. |
{"1011": 0.08154398202896118, "1015": 0.2089812457561493, "1020": 0.012615402229130268, "1023": 0.12470348179340363, "1043": 0.5472630262374878, "1044": 0.5016035437583923, "1048": 0.006812678650021553, "1056": 0.3662964701652527, "1999": 0.05970508232712746, "2003": 0.09228714555501938, "2007": 0.35334911942481995, "2... | 5476778 | One hypothesis that couples infection with autoimmune disease is molecular mimicry. Molecular mimicry is characterized by an immune response to an environmental agent that cross-reacts with a host antigen, resulting in disease. This hypothesis has been implicated in the pathogenesis of diabetes, lupus and multiple scle... | Autoimmunity due to molecular mimicry as a cause of neurological disease |
{"1009": 0.7737906575202942, "1011": 0.41647201776504517, "1022": 0.7258110046386719, "1039": 0.14602625370025635, "1056": 0.956112265586853, "2003": 0.0009760859538801014, "2007": 0.16607704758644104, "2010": 0.8135309815406799, "2011": 0.33115679025650024, "2015": 0.30558720231056213, "2026": 0.7692760229110718, "202... | 5483793 | Antigen-specific CD8+ T-cell tolerance, induced by myeloid-derived suppressor cells (MDSCs), is one of the main mechanisms of tumor escape. Using in vivo models, we show here that MDSCs directly disrupt the binding of specific peptide–major histocompatibility complex (pMHC) dimers to CD8-expressing T cells through nitr... | Altered recognition of antigen is a mechanism of CD8+ T cell tolerance in cancer |
{"1038": 0.09495500475168228, "1039": 0.9317949414253235, "1052": 0.9131608605384827, "1054": 0.5805994272232056, "2007": 0.11343330889940262, "2010": 0.034552380442619324, "2011": 0.24325250089168549, "2029": 0.016465263441205025, "2076": 0.2561853528022766, "2094": 0.8949713706970215, "2184": 0.4624064862728119, "220... | 5484763 | Chronic granulomatous disease (CGD), an immunodeficiency with recurrent pyogenic infections and granulomatous inflammation, results from loss of phagocyte superoxide production by recessive mutations in any 1 of 4 genes encoding subunits of the phagocyte NADPH oxidase. These include gp91(phox) and p22(phox), which form... | A new genetic subgroup of chronic granulomatous disease with autosomal recessive mutations in p40 phox and selective defects in neutrophil NADPH oxidase activity. |
{"1003": 0.05417001247406006, "1014": 0.24554696679115295, "1023": 0.025073638185858727, "1052": 0.30558720231056213, "2007": 0.020300358533859253, "2022": 0.05786345899105072, "2071": 0.18573370575904846, "2084": 0.036437395960092545, "2109": 0.27044451236724854, "2124": 0.0842406153678894, "2132": 0.4909018874168396,... | 5487448 | Birth weight is a significant predictor of breast cancer risk in adult life and mammary gland mass could be an intermediate stage in this long process. We have studied the association of birth size measurements with mammographic density, a marker of mammary gland mass. For a population-based sample of 893 postmenopausa... | Birth weight and mammographic density among postmenopausal women in Sweden. |
{"1015": 0.04113444685935974, "1043": 0.058784693479537964, "1045": 0.1619328260421753, "2003": 0.46363574266433716, "2005": 0.1212492436170578, "2012": 0.23787821829319, "2026": 0.07159364968538284, "2033": 0.036437395960092545, "2034": 0.2837681770324707, "2038": 0.06703783571720123, "2051": 0.018384648486971855, "20... | 5492542 | The antimycotic ciclopirox olamine is an intracellular iron chelator that has anticancer activity in vitro and in vivo. We developed an oral formulation of ciclopirox olamine and conducted the first-in-human phase I study of this drug in patients with relapsed or refractory hematologic malignancies (Trial registration ... | Oral ciclopirox olamine displays biological activity in a phase I study in patients with advanced hematologic malignancies. |
{"1017": 0.20977331697940826, "1039": 0.574020504951477, "1045": 0.5151132941246033, "1056": 0.7314660549163818, "1060": 0.18004031479358673, "1155": 0.1011524572968483, "1156": 0.2160874605178833, "1999": 0.004870930220931768, "2011": 0.7182208299636841, "2029": 0.1994270235300064, "2044": 0.07159364968538284, "2065":... | 5500086 | Some of the anti-neoplastic effects of anthracyclines in mice originate from the induction of innate and T cell–mediated anticancer immune responses. Here we demonstrate that anthracyclines stimulate the rapid production of type I interferons (IFNs) by malignant cells after activation of the endosomal pattern recogniti... | Cancer cell–autonomous contribution of type I interferon signaling to the efficacy of chemotherapy |
{"1011": 0.39433568716049194, "1039": 0.16276304423809052, "1041": 0.13670019805431366, "1060": 0.10906458646059036, "1155": 0.4228905141353607, "1996": 0.0842406153678894, "2007": 0.20660123229026794, "2029": 0.18248429894447327, "2037": 0.04113444685935974, "2063": 0.8715548515319824, "2076": 0.5347557663917542, "207... | 5503194 | During development, cells monitor and adjust their rates of accumulation to produce organs of predetermined size. We show here that central nervous system-specific deletion of the essential adherens junction gene, alphaE-catenin, causes abnormal activation of the hedgehog pathway, resulting in shortening of the cell cy... | alphaE-catenin controls cerebral cortical size by regulating the hedgehog signaling pathway. |
{"1048": 0.6312094330787659, "1056": 1.190008521080017, "1998": 0.03925827145576477, "2003": 0.22859740257263184, "2015": 0.08154398202896118, "2054": 0.14349138736724854, "2076": 0.176772341132164, "2079": 0.10203468054533005, "2083": 0.006812678650021553, "2104": 0.0752234235405922, "2140": 0.2231435477733612, "2182"... | 5508750 | Immunological memory is a cardinal feature of adaptive immunity and an important goal of vaccination strategies. Here we highlight advances in the understanding of the diverse T lymphocyte subsets that provide acute and long-term protection from infection. These include new insights into the transcription factors, and ... | Molecular regulation of effector and memory T cell differentiation |
{"1011": 0.13499516248703003, "1015": 0.5057345628738403, "1016": 0.5045560002326965, "1018": 0.176772341132164, "1047": 0.672426164150238, "1702": 0.06612417846918106, "1996": 0.16690383851528168, "2002": 0.6011518239974976, "2003": 0.17840765416622162, "2008": 0.07884006202220917, "2011": 0.23092569410800934, "2024":... | 5511240 | Kupffer cells, the phagocytes of fetal origin that line the liver sinusoids, are key contributors of host defense against enteroinvasive bacteria. Here, we found that infection by Listeria monocytogenes induced the early necroptotic death of Kupffer cells, which was followed by monocyte recruitment and an anti-bacteria... | Liver-resident macrophage necroptosis orchestrates type 1 microbicidal inflammation and type-2-mediated tissue repair during bacterial infection. |
{"1011": 0.0058422754518687725, "1048": 1.0001721382141113, "2003": 0.0354953333735466, "2005": 0.09672962874174118, "2007": 0.11951763927936554, "2008": 0.0038986403960734606, "2011": 0.2089812457561493, "2015": 0.5756692886352539, "2024": 0.2501201331615448, "2029": 0.10993985831737518, "2050": 0.19622190296649933, "... | 5519177 | Long noncoding RNAs (lncRNAs) are emerging as critical regulators of gene expression in the immune system. Studies have shown that lncRNAs are expressed in a highly lineage-specific manner and control the differentiation and function of innate and adaptive cell types. In this Review, we focus on mechanisms used by lncR... | Gene regulation in the immune system by long noncoding RNAs |
{"1011": 0.1889725625514984, "1045": 0.5685047507286072, "1048": 0.8357921838760376, "1049": 0.6926587820053101, "1999": 0.23092569410800934, "2005": 0.11778303235769272, "2008": 0.0354953333735466, "2009": 0.21135559678077698, "2011": 0.3615458607673645, "2015": 0.03360854089260101, "2029": 0.28155985474586487, "2043"... | 5531479 | Neutrophils rapidly undergo polarization and directional movement to infiltrate the sites of infection and inflammation. Here, we show that an inhibitory MHC I receptor, Ly49Q, was crucial for the swift polarization of and tissue infiltration by neutrophils. During the steady state, Ly49Q inhibited neutrophil adhesion ... | The Ly49Q receptor plays a crucial role in neutrophil polarization and migration by regulating raft trafficking. |
{"1003": 0.15526613593101501, "1022": 0.03925827145576477, "1047": 0.2659635543823242, "1049": 0.5968599319458008, "1050": 0.3346569836139679, "1057": 0.1384023278951645, "1061": 1.0409941673278809, "2001": 0.3777405619621277, "2002": 0.09850110858678818, "2007": 0.23015019297599792, "2012": 0.09317722171545029, "2014"... | 5548081 | CONTEXT Some studies have inferred that an epidemic of Kaposi sarcoma-associated herpesvirus (KSHV) infection in homosexual men in the United States occurred concurrently with that of human immunodeficiency virus (HIV), but there have been no direct measurements of KSHV prevalence at the beginning of the HIV epidemic. ... | Prevalence of Kaposi sarcoma-associated herpesvirus infection in homosexual men at beginning of and during the HIV epidemic. |
{"1051": 0.0752234235405922, "2003": 0.12384103983640671, "2005": 0.6022219061851501, "2012": 0.11691460013389587, "2041": 0.016465263441205025, "2042": 0.07612881064414978, "2053": 0.018384648486971855, "2064": 0.17759032547473907, "2078": 0.1710275560617447, "2079": 0.2516399025917053, "2109": 0.07250232994556427, "2... | 5551138 | This article reviews the efficacy of nortriptyline for smoking cessation based on a meta-analysis of the Cochrane Library. Six placebo-controlled trials have shown nortriptyline (75-100 mg) doubles quit rates (OR = 2.1). Between 4% and 12% of smokers dropped out because of adverse events, but no serious adverse events ... | Nortriptyline for smoking cessation: a review. |
{"1017": 0.2674594223499298, "1040": 0.6176109313964844, "1041": 0.24018502235412598, "1998": 0.31560876965522766, "2003": 0.040196798741817474, "2007": 0.07431721687316895, "2013": 0.037378571927547455, "2029": 0.03266380727291107, "2064": 0.04674193635582924, "2071": 0.21687394380569458, "2075": 0.0029254043474793434... | 5556809 | Although it has long been recognized that many individuals with attention deficit hyperactivity disorder (ADHD) also have difficulties with emotion regulation, no consensus has been reached on how to conceptualize this clinically challenging domain. The authors examine the current literature using both quantitative and... | Emotion dysregulation in attention deficit hyperactivity disorder. |
{"1013": 0.07159364968538284, "1014": 0.5057345628738403, "1028": 0.08782484382390976, "1039": 0.7854343056678772, "1048": 0.24631060659885406, "1052": 0.6823468804359436, "1053": 0.1384023278951645, "1164": 0.6249561905860901, "1997": 0.08064348995685577, "2001": 0.08692999184131622, "2002": 0.11778303235769272, "2004... | 5558754 | OBJECTIVES To quantify the diagnostic accuracy of selected inflammatory markers in addition to symptoms and signs for predicting pneumonia and to derive a diagnostic tool. DESIGN Diagnostic study performed between 2007 and 2010. Participants had their history taken, underwent physical examination and measurement of C r... | Use of serum C reactive protein and procalcitonin concentrations in addition to symptoms and signs to predict pneumonia in patients presenting to primary care with acute cough: diagnostic study |
{"1011": 0.1930064558982849, "1015": 0.6892333030700684, "1038": 0.34023189544677734, "1042": 0.7220231294631958, "1045": 0.0317181795835495, "1999": 0.05970508232712746, "2003": 0.009718249551951885, "2005": 0.19782574474811554, "2011": 0.2223619967699051, "2015": 0.42096930742263794, "2024": 0.19862671196460724, "202... | 5560962 | Broadly neutralizing antibodies (bNAbs) to HIV-1 can prevent infection and are therefore of great importance for HIV-1 vaccine design. Notably, bNAbs are highly somatically mutated and generated by a fraction of HIV-1-infected individuals several years after infection. Antibodies typically accumulate mutations in the c... | Somatic Mutations of the Immunoglobulin Framework Are Generally Required for Broad and Potent HIV-1 Neutralization |
{"1011": 0.10203468054533005, "1015": 1.0815403461456299, "1038": 0.32905077934265137, "1044": 0.6107416749000549, "1045": 0.43434104323387146, "1056": 0.5640701055526733, "1997": 0.10203468054533005, "1998": 0.0038986403960734606, "2011": 0.15693697333335876, "2015": 0.08871890604496002, "2028": 0.6931471824645996, "2... | 5567005 | Recent genetic mapping and gene-phenotype studies have revealed the genetic architecture of type 1 diabetes. At least ten genes so far can be singled out as strong causal candidates. The known functions of these genes indicate the primary etiological pathways of this disease, including HLA class II and I molecules bind... | Etiology of type 1 diabetes. |
{"2005": 0.26820653676986694, "2006": 0.08064348995685577, "2013": 0.04767346754670143, "2029": 0.018384648486971855, "2037": 0.10818854719400406, "2043": 0.014542185701429844, "2044": 0.18492233753204346, "2049": 0.25239890813827515, "2064": 0.5255602598190308, "2071": 0.14264501631259918, "2076": 0.21530038118362427,... | 5567223 | Tissues rely upon stem cells for homeostasis and repair. Recent studies show that the fate and multilineage potential of epithelial stem cells can change depending on whether a stem cell exists within its resident niche and responds to normal tissue homeostasis, whether it is mobilized to repair a wound, or whether it ... | Plasticity of epithelial stem cells in tissue regeneration |
{"1009": 0.2478361576795578, "1011": 0.04953393340110779, "1022": 0.36967599391937256, "1050": 0.022212404757738113, "1056": 0.3870677351951599, "1999": 0.053244512528181076, "2004": 0.004870930220931768, "2007": 0.09228714555501938, "2011": 0.26820653676986694, "2015": 0.3034266233444214, "2020": 0.045809537172317505,... | 5572127 | The role of ataxia telangiectasia mutated (ATM), a DNA double-strand break recognition and response protein, in inflammation and inflammatory diseases is unclear. We have previously shown that high levels of systemic DNA damage are induced by intestinal inflammation in wild-type mice. To determine the effect of Atm def... | Atm-deficient mice exhibit increased sensitivity to dextran sulfate sodium-induced colitis characterized by elevated DNA damage and persistent immune activation. |
{"1011": 0.2711893916130066, "1017": 0.4624064862728119, "1038": 0.9754437208175659, "1056": 0.8973627090454102, "1156": 0.6759096384048462, "1999": 0.016465263441205025, "2004": 0.052318159490823746, "2005": 0.029824240133166313, "2007": 0.22782009840011597, "2008": 0.10818854719400406, "2011": 0.04487626627087593, "2... | 5573975 | Molecules associated with the transforming growth factor β (TGF-β) superfamily, such as bone morphogenic proteins (BMPs) and TGF-β, are key regulators of inflammation, apoptosis and cellular transitions. Here we show that the BMP receptor activin-like kinase 3 (Alk3) is elevated early in diseased kidneys after injury. ... | Activin–like kinase–3 activity is important for kidney regeneration and reversal of fibrosis |
{"1011": 0.11951763927936554, "1039": 0.2800849378108978, "1997": 0.32553088665008545, "2003": 0.3897167444229126, "2008": 0.08154398202896118, "2029": 0.0606246218085289, "2050": 0.36900100111961365, "2069": 0.176772341132164, "2103": 0.8699195384979248, "2109": 0.14686977863311768, "2232": 0.2247048318386078, "2240":... | 5579368 | COHCAP (City of Hope CpG Island Analysis Pipeline) is an algorithm to analyze single-nucleotide resolution DNA methylation data produced by either an Illumina methylation array or targeted bisulfite sequencing. The goal of the COHCAP algorithm is to identify CpG islands that show a consistent pattern of methylation amo... | COHCAP: an integrative genomic pipeline for single-nucleotide resolution DNA methylation analysis |
{"2007": 0.08244366943836212, "2034": 0.0913962796330452, "2047": 0.2800849378108978, "2052": 0.2516399025917053, "2064": 0.05417001247406006, "2065": 0.10818854719400406, "2071": 0.5063233375549316, "2075": 0.49626702070236206, "2079": 0.33675122261047363, "2109": 0.11430477350950241, "2129": 0.043007105588912964, "21... | 5586392 | BACKGROUND Patients with neuropathic pain present with various pain-related sensory abnormalities. These sensory features form different patterns or mosaics-the sensory profile-in individual patients. One hypothesis for the development of sensory profiles is that distinct pathophysiological mechanisms of pain generatio... | Subgrouping of patients with neuropathic pain according to pain-related sensory abnormalities: a first step to a stratified treatment approach. |
{"1040": 0.10379679501056671, "1044": 0.20977331697940826, "1998": 0.2652147710323334, "2001": 0.04394211992621422, "2004": 0.18004031479358673, "2022": 0.18004031479358673, "2043": 0.053244512528181076, "2064": 0.18329764902591705, "2084": 0.32905077934265137, "2109": 0.06977381557226181, "2128": 0.2247048318386078, "... | 5596332 | IMPORTANCE Definitions of sepsis and septic shock were last revised in 2001. Considerable advances have since been made into the pathobiology (changes in organ function, morphology, cell biology, biochemistry, immunology, and circulation), management, and epidemiology of sepsis, suggesting the need for reexamination. O... | The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3). |
{"1011": 0.16442140936851501, "1014": 0.3318578004837036, "1043": 0.42096930742263794, "1052": 0.5324648022651672, "2004": 0.9798521995544434, "2007": 0.672426164150238, "2012": 0.04394211992621422, "2019": 0.5033760666847229, "2044": 0.1913948506116867, "2051": 0.15359249711036682, "2053": 0.02792670577764511, "2064":... | 5597586 | OBJECTIVES Patients with AL amyloidosis can benefit from high-dose chemotherapy and autologous stem cell transplantation (ASCT). Transplantation can be challenging due to fluid shifts, sepsis, and cardiac dysrhythmias. Amyloidosis may present with autonomic neuropathy (AN) that renders peritransplant care problematic. ... | Stem cell transplantation in patients with autonomic neuropathy due to primary (AL) amyloidosis. |
{"1011": 0.29328158497810364, "1013": 0.05417001247406006, "1039": 0.6394867897033691, "1044": 0.08513788133859634, "2002": 0.9576126337051392, "2003": 0.05417001247406006, "2004": 0.05694137513637543, "2005": 0.20022670924663544, "2008": 0.07793712615966797, "2029": 0.1751343309879303, "2044": 0.06520967930555344, "20... | 5612738 | The hepatic low-density lipoprotein receptor (LDLR) pathway is essential for clearing circulating LDL cholesterol (LDL-C). Whereas the transcriptional regulation of LDLR is well characterized, the post-transcriptional mechanisms that govern LDLR expression are just beginning to emerge. Here we develop a high-throughput... | MicroRNA-148a regulates LDL receptor and ABCA1 expression to control circulating lipoprotein levels |
{"1011": 0.1212492436170578, "1038": 1.1714173555374146, "1042": 0.6813592314720154, "2002": 0.8699195384979248, "2005": 0.014542185701429844, "2007": 0.33675122261047363, "2008": 0.036437395960092545, "2015": 0.15610189735889435, "2029": 0.29981520771980286, "2033": 0.8057082891464233, "2079": 0.2493593990802765, "208... | 5633876 | BMP is thought to induce hESC differentiation toward multiple lineages including mesoderm and trophoblast. The BMP-induced trophoblast phenotype is a long-standing paradox in stem cell biology. Here we readdressed BMP function in hESCs and mouse epiblast-derived cells. We found that BMP4 cooperates with FGF2 (via ERK) ... | BRACHYURY and CDX2 Mediate BMP-Induced Differentiation of Human and Mouse Pluripotent Stem Cells into Embryonic and Extraembryonic Lineages |
{"1011": 0.23479416966438293, "1013": 0.1332872211933136, "1017": 0.3423145115375519, "1020": 0.02316705882549286, "1038": 0.672426164150238, "1048": 0.6583697199821472, "1058": 0.014542185701429844, "2011": 0.4412745535373688, "2012": 0.3339579105377197, "2029": 0.2247048318386078, "2043": 0.052318159490823746, "2044"... | 5633957 | Cytomegaloviruses express large amounts of viral miRNAs during lytic infection, yet, they only modestly alter the cellular miRNA profile. The most prominent alteration upon lytic murine cytomegalovirus (MCMV) infection is the rapid degradation of the cellular miR-27a and miR-27b. Here, we report that this regulation is... | Degradation of Cellular miR-27 by a Novel, Highly Abundant Viral Transcript Is Important for Efficient Virus Replication In Vivo |
{"1014": 0.4938860833644867, "1018": 0.7105726003646851, "1020": 0.14179791510105133, "1023": 0.06520967930555344, "1052": 0.034552380442619324, "1053": 0.3127557039260864, "1997": 0.13499516248703003, "2000": 0.19622190296649933, "2001": 0.016465263441205025, "2012": 0.058784693479537964, "2020": 0.08244366943836212, ... | 5641851 | OBJECTIVE Cancer outcomes vary between and within countries with patients from deprived backgrounds known to have inferior survival. The authors set out to explore the effect of deprivation in relation to the accessibility of hospitals offering diagnostic and therapeutic services on stage at presentation and receipt of... | Social and geographical factors affecting access to treatment of colorectal cancer: a cancer registry study |
{"1011": 0.11604541540145874, "1014": 0.41840189695358276, "1015": 0.06520967930555344, "1016": 0.2689530849456787, "1017": 0.3601844012737274, "1040": 0.08513788133859634, "1045": 0.20818853378295898, "1050": 0.43244171142578125, "1052": 0.49626702070236206, "2029": 0.0752234235405922, "2064": 0.03925827145576477, "20... | 5649538 | Patient selection is important for targeted therapies, yet phase I/II trials are often underpowered for developing predictors of drug response. The goal of this research was to define genomic predictors for dasatinib that could be prospectively tested in early-phase clinical trials. Gene expression profiles of dasatini... | Development of candidate genomic markers to select breast cancer patients for dasatinib therapy. |
{"1009": 0.2652147710323334, "1013": 0.02412080205976963, "1039": 0.3995884954929352, "1041": 0.40546512603759766, "1043": 1.0257055759429932, "2000": 0.10379679501056671, "2003": 0.18004031479358673, "2005": 0.04953393340110779, "2007": 0.1930064558982849, "2015": 0.0317181795835495, "2064": 0.38905516266822815, "2075... | 5650232 | MOTIVATION Testing for correlations between different sets of genomic features is a fundamental task in genomics research. However, searching for overlaps between features with existing web-based methods is complicated by the massive datasets that are routinely produced with current sequencing technologies. Fast and fl... | BEDTools: a flexible suite of utilities for comparing genomic features |
{"1014": 0.503966212272644, "1016": 0.8247235417366028, "1019": 0.11865071207284927, "1026": 0.06246116757392883, "1039": 0.6613984704017639, "1043": 0.3283478021621704, "1052": 0.6212902665138245, "1997": 0.06977381557226181, "1998": 0.0174254160374403, "2001": 0.043007105588912964, "2007": 0.0029254043474793434, "202... | 5687200 | AIMS The aim of this study was to compare the effects of calorie-restricted vegetarian and conventional diabetic diets alone and in combination with exercise on insulin resistance, visceral fat and oxidative stress markers in subjects with Type 2 diabetes. METHODS A 24-week, randomized, open, parallel design was used. ... | Vegetarian diet improves insulin resistance and oxidative stress markers more than conventional diet in subjects with Type 2 diabetes |
{"1044": 0.08154398202896118, "1053": 0.9052929878234863, "1054": 0.13414156436920166, "2001": 0.025073638185858727, "2004": 0.3084607720375061, "2007": 0.015504186972975731, "2019": 0.5063233375549316, "2020": 0.1619328260421753, "2026": 0.10993985831737518, "2031": 0.02887592278420925, "2039": 0.1212492436170578, "20... | 5691302 | OBJECTIVES To investigate the association between antidepressant treatment and risk of several potential adverse outcomes in older people with depression and to examine risks by class of antidepressant, duration of use, and dose. DESIGN Cohort study of people aged 65 and over diagnosed as having depression. SETTING 570... | Antidepressant use and risk of adverse outcomes in older people: population based cohort study |
{"1014": 0.21214580535888672, "1053": 0.5255602598190308, "2001": 0.013579257763922215, "2007": 0.009718249551951885, "2020": 0.0058422754518687725, "2021": 0.083342544734478, "2035": 0.6006163358688354, "2053": 0.22859740257263184, "2086": 0.36697331070899963, "2095": 0.18167030811309814, "2100": 0.09584271162748337, ... | 5698494 | OBJECTIVES To investigate whether statins reduce all cause mortality and major coronary and cerebrovascular events in people without established cardiovascular disease but with cardiovascular risk factors, and whether these effects are similar in men and women, in young and older (>65 years) people, and in people with ... | The benefits of statins in people without established cardiovascular disease but with cardiovascular risk factors: meta-analysis of randomised controlled trials |
{"1011": 0.18004031479358673, "1040": 0.0752234235405922, "1050": 0.6471850275993347, "1996": 0.2184450328350067, "1997": 0.08154398202896118, "1999": 0.011650617234408855, "2003": 0.0752234235405922, "2011": 0.25845035910606384, "2026": 0.7701805830001831, "2029": 0.12038381397724152, "2046": 0.24248650670051575, "206... | 5700349 | The morphology of neuronal dendritic spines is a critical indicator of synaptic function. It is regulated by several factors, including the intracellular actin/myosin cytoskeleton and transcellular N-cadherin adhesions. To examine the mechanical relationship between these molecular components, we performed quantitative... | Mechanical coupling between transsynaptic N-cadherin adhesions and actin flow stabilizes dendritic spines |
{"1011": 0.5461324453353882, "1015": 0.417115718126297, "1016": 0.6754127144813538, "1039": 0.1751343309879303, "1040": 0.2719337046146393, "1054": 0.5244048833847046, "1999": 0.010684899985790253, "2002": 0.47584590315818787, "2005": 0.1212492436170578, "2008": 0.15860503911972046, "2011": 0.2018241584300995, "2013": ... | 5702790 | Drosophila Dicer-2 generates small interfering RNAs (siRNAs) from long double-stranded RNA (dsRNA), whereas Dicer-1 produces microRNAs (miRNAs) from pre-miRNA. What makes the two Dicers specific for their biological substrates? We find that purified Dicer-2 can efficiently cleave pre-miRNA, but that inorganic phosphate... | Phosphate and R2D2 restrict the substrate specificity of Dicer-2, an ATP-driven ribonuclease. |
{"1038": 0.6989894509315491, "1043": 0.13243216276168823, "1048": 0.15777134895324707, "1058": 0.129004567861557, "1998": 0.25088030099868774, "2003": 0.0317181795835495, "2004": 0.02887592278420925, "2005": 0.503966212272644, "2010": 0.6744182109832764, "2011": 0.052318159490823746, "2024": 0.07341018319129944, "2029"... | 5704562 | The mood stabilizers lithium and valproic acid (VPA) are traditionally used to treat bipolar disorder (BD), a severe mental illness arising from complex interactions between genes and environment that drive deficits in cellular plasticity and resiliency. The therapeutic potential of these drugs in other central nervous... | Therapeutic potential of mood stabilizers lithium and valproic acid: beyond bipolar disorder. |
{"1017": 0.3982778787612915, "1020": 0.04860413447022438, "1999": 0.06246116757392883, "2000": 0.29036402702331543, "2001": 0.14518201351165771, "2038": 0.18004031479358673, "2040": 0.3353555500507355, "2041": 0.03831886500120163, "2042": 0.3283478021621704, "2043": 0.3464667797088623, "2045": 0.23324857652187347, "204... | 5710820 | BACKGROUND Following the last major malaria epidemic in 2000, malaria incidence in South Africa has declined markedly. The decrease has been so emphatic that South Africa now meets the World Health Organization (WHO) threshold for malaria elimination. Given the Millennium Development Goal of reversing the spread of mal... | The feasibility of malaria elimination in South Africa |
{"1003": 0.020300358533859253, "1014": 0.5789587497711182, "1015": 0.3170322775840759, "1016": 0.3560888469219208, "1020": 0.2674594223499298, "1026": 0.04207121208310127, "1038": 0.6950984001159668, "1039": 0.5063233375549316, "1044": 0.3910386264324188, "1052": 0.472198486328125, "2001": 0.11517547070980072, "2002": ... | 5735492 | BACKGROUND HIV disproportionately affects African-Caribbean women in Canada but the frequency and distribution of sexually transmitted infections in this community have not been previously studied. METHODS We recruited women based on HIV status through a Toronto community health centre. Participants completed a socio-b... | The epidemiology of sexually transmitted co-infections in HIV-positive and HIV-negative African-Caribbean women in Toronto |
{"1011": 0.41065993905067444, "1015": 0.7737906575202942, "1040": 0.18411032855510712, "1052": 0.4879087805747986, "1056": 0.7872136831283569, "1999": 0.052318159490823746, "2011": 0.4512746334075928, "2028": 0.3423145115375519, "2029": 0.175953671336174, "2047": 0.1930064558982849, "2058": 0.7220231294631958, "2063": ... | 5752492 | Chronic immune activation that persists despite anti-retroviral therapy (ART) is the strongest predictor of disease progression in HIV infection. Monocyte/macrophages in HIV-infected individuals are known to spontaneously secrete cytokines, although neither the mechanism nor the molecules involved are known. Here we sh... | Characterization of Programmed Death-1 Homologue-1 (PD-1H) Expression and Function in Normal and HIV Infected Individuals |
{"1011": 0.5495203733444214, "1035": 0.036437395960092545, "1037": 0.6202403903007507, "1039": 0.8550800085067749, "1044": 0.27712854743003845, "1996": 0.32270604372024536, "1997": 0.0038986403960734606, "1999": 0.2689530849456787, "2002": 0.0842406153678894, "2008": 0.11256109178066254, "2010": 0.9987343549728394, "20... | 5760247 | Chromosome segregation during mitosis requires assembly of the kinetochore complex at the centromere. Kinetochore assembly depends on specific recognition of the histone variant CENP-A in the centromeric nucleosome by centromere protein C (CENP-C). We have defined the determinants of this recognition mechanism and disc... | A conserved mechanism for centromeric nucleosome recognition by centromere protein CENP-C. |
{"1042": 0.07341018319129944, "2000": 0.0913962796330452, "2025": 0.10467668622732162, "2046": 0.06429435312747955, "2047": 0.42353010177612305, "2054": 0.022212404757738113, "2057": 0.004870930220931768, "2064": 0.17020416259765625, "2069": 0.06246116757392883, "2070": 0.28082266449928284, "2071": 0.030771657824516296... | 5764562 | The visualization of biologically relevant molecules and activities inside living cells continues to transform cell biology into a truly quantitative science. However, despite the spectacular achievements in some areas of cell biology, the majority of cellular processes still operate invisibly, not illuminated by even ... | Chemical tools for biomolecular imaging. |
{"1011": 0.09850110858678818, "1016": 0.034552380442619324, "1049": 0.09317722171545029, "1050": 0.09584271162748337, "1055": 0.15359249711036682, "2003": 0.13925230503082275, "2011": 0.21293537318706512, "2015": 1.185243844985962, "2026": 1.1573970317840576, "2029": 0.010684899985790253, "2033": 0.19541899859905243, "... | 5765455 | Myelodysplastic syndromes (MDS) comprise a heterogeneous group of disorders characterized by ineffective hematopoiesis, with an increased propensity to develop acute myelogenous leukemia (AML). The molecular basis for MDS progression is unknown, but a key element in MDS disease progression is loss of chromosomal materi... | Reactive oxygen species, DNA damage, and error-prone repair: a model for genomic instability with progression in myeloid leukemia? |
{"1011": 0.36358460783958435, "1017": 0.22859740257263184, "1018": 0.18816383183002472, "1022": 0.045809537172317505, "1043": 0.09584271162748337, "1055": 1.1641268730163574, "1056": 0.4950772523880005, "1164": 0.6170841455459595, "2004": 0.022212404757738113, "2005": 0.026025565341114998, "2011": 0.2184450328350067, "... | 5774746 | S100A4 is implicated in metastasis and chronic inflammation, but its function remains uncertain. Here we establish an S100A4-dependent link between inflammation and metastatic tumor progression. We found that the acute-phase response proteins serum amyloid A (SAA) 1 and SAA3 are transcriptional targets of S100A4 via To... | A link between inflammation and metastasis: serum amyloid A1 and A3 induce metastasis, and are targets of metastasis-inducing S100A4 |
{"1009": 0.02316705882549286, "1011": 0.22782009840011597, "1014": 0.09584271162748337, "1040": 0.25239890813827515, "1044": 0.05417001247406006, "1051": 0.4267219603061676, "1052": 0.6704301834106445, "1059": 0.23864774405956268, "1998": 0.12384103983640671, "1999": 0.2447827309370041, "2000": 0.29036402702331543, "20... | 5775033 | Pyruvate dehydrogenase activity (PDHa) and acetyl group accumulation were examined in human skeletal muscle at rest and during exercise after different diets. Five males cycled at 75% of maximal O2 uptake (VO2 max) to exhaustion after consuming a low-carbohydrate diet (LCD) for 3 days and again 1-2 wk later for the sam... | Pyruvate dehydrogenase activity and acetyl group accumulation during exercise after different diets. |
{"1011": 0.11256109178066254, "1038": 0.6512666940689087, "1040": 0.2478361576795578, "1044": 0.14179791510105133, "1048": 0.5370414853096008, "1999": 0.025073638185858727, "2002": 0.2763880789279938, "2003": 0.1485546976327896, "2015": 0.9302552938461304, "2019": 0.15693697333335876, "2026": 0.8195732831954956, "2035"... | 5782614 | Recent genetic analyses of large populations have revealed that somatic mutations in hematopoietic cells leading to clonal expansion are commonly acquired during human aging. Clonally restricted hematopoiesis is associated with an increased risk of subsequent diagnosis of myeloid or lymphoid neoplasia and increased all... | Clonal hematopoiesis of indeterminate potential and its distinction from myelodysplastic syndromes. |
{"1011": 0.34370049834251404, "1043": 0.7445381283760071, "1044": 0.25088030099868774, "1049": 0.03925827145576477, "2003": 0.013579257763922215, "2004": 0.1477125883102417, "2005": 0.15023678541183472, "2011": 0.319873183965683, "2015": 0.44753631949424744, "2026": 0.5668440461158752, "2029": 0.13670019805431366, "204... | 5783785 | The discovery of microRNAs (miRNAs) provides a new and powerful tool for studying the mechanism, diagnosis and treatment of human cancers. Currently, down-regulation of tumor suppressive miRNAs by CpG island hypermethylation is emerging as a common hallmark of cancer. Here, we reported that the down-regulation of miR-3... | DNA Methylation mediated down-regulating of MicroRNA-33b and its role in gastric cancer |
{"1011": 0.06246116757392883, "1043": 0.029824240133166313, "1048": 0.5336109399795532, "1050": 0.5472630262374878, "1051": 0.08244366943836212, "1062": 0.9463045597076416, "1997": 0.07250232994556427, "2002": 0.4926934838294983, "2003": 0.1808556467294693, "2008": 0.04674193635582924, "2011": 0.35813871026039124, "202... | 5785219 | Nitric oxide (NO) is a product of L-arginine metabolism that suppresses cellular oxidative metabolism through the inhibition of tricarboxylic acid cycle and electron transport chain enzymes. The impact of NO synthase (NOS) activity on specific pathways of glucose metabolism in freshly harvested and overnight-cultured r... | Modulation of glucose metabolism in macrophages by products of nitric oxide synthase. |
{"1009": 0.38441169261932373, "1011": 0.0038986403960734606, "1015": 0.1619328260421753, "1018": 0.08064348995685577, "1045": 0.13157635927200317, "1048": 0.23324857652187347, "1050": 0.5979346632957458, "1052": 0.35813871026039124, "1056": 0.736154317855835, "1164": 0.0770333781838417, "2008": 0.04860413447022438, "20... | 5798227 | Bacterial lipopolysaccharide (LPS) triggers innate immune responses through Toll-like receptor (TLR) 4. We show here that the suppressor of cytokine-signaling-1 (SOCS1/JAB) is rapidly induced by LPS and negatively regulates LPS signaling. SOCS1(+/-) mice or SOCS1(-/-) mice with interferon-gamma (IFNgamma)-deficient bac... | SOCS1/JAB is a negative regulator of LPS-induced macrophage activation. |
{"1009": 0.5364705324172974, "1011": 0.1946154683828354, "1018": 0.23864774405956268, "1044": 0.27712854743003845, "1056": 0.7610978484153748, "1059": 1.0519683361053467, "1156": 0.6086184978485107, "1157": 0.6664261221885681, "1999": 0.06246116757392883, "2002": 0.8383291959762573, "2004": 0.022212404757738113, "2007"... | 5800138 | We have previously demonstrated that interleukin (IL)-10–deficient (IL-10 knockout [KO]) but not wild-type (WT) mice develop colitis after infection with Helicobacter hepaticus . Here, we show that infected recombination activating gene (RAG) KO mice develop intestinal inflammation after reconstitution with CD4+ T cell... | Bacteria-triggered CD4+ T Regulatory Cells Suppress Helicobacter hepaticus–induced Colitis |
{"1009": 0.20818853378295898, "1011": 0.19782574474811554, "1018": 0.5156965255737305, "1048": 0.28963330388069153, "1050": 0.7755908370018005, "1052": 0.5517725944519043, "1056": 0.8941729068756104, "1164": 0.5133614540100098, "2012": 0.4831010699272156, "2029": 0.1913948506116867, "2063": 0.23556606471538544, "2076":... | 5811042 | Missense mutations in the nucleotide-binding oligomerization domain (NOD)-like receptor pyrin domain containing family of gene 12 (Nlrp12) are associated with periodic fever syndromes and atopic dermatitis in humans. Here, we have demonstrated a crucial role for NLRP12 in negatively regulating pathogenic T cell respons... | The NLRP12 Sensor Negatively Regulates Autoinflammatory Disease by Modulating Interleukin-4 Production in T Cells. |
{"1011": 0.10467668622732162, "1055": 0.12384103983640671, "1164": 0.24401791393756866, "2007": 0.2247048318386078, "2011": 0.4002431631088257, "2012": 0.8074519634246826, "2029": 0.15275461971759796, "2033": 0.4425300657749176, "2073": 0.0317181795835495, "2076": 0.07884006202220917, "2079": 0.010684899985790253, "208... | 5821617 | Atherosclerotic plaques develop in regions of the vasculature associated with chronic inflammation due to disturbed flow patterns. Endothelial phenotype modulation by flow requires the integration of numerous mechanotransduction pathways, but how this is achieved is not well understood. We show here that, in response t... | Shc coordinates signals from intercellular junctions and integrins to regulate flow-induced inflammation |
{"1015": 0.22548456490039825, "1016": 0.30917787551879883, "1043": 0.040196798741817474, "2002": 0.09672962874174118, "2008": 0.08782484382390976, "2010": 0.8973627090454102, "2011": 0.0058422754518687725, "2029": 0.2531573474407196, "2043": 0.11430477350950241, "2049": 0.007782140281051397, "2075": 0.2026219218969345,... | 5824955 | Genomic instability and alterations in gene expression are hallmarks of eukaryotic aging. The yeast histone deacetylase Sir2 silences transcription and stabilizes repetitive DNA, but during aging or in response to a DNA break, the Sir complex relocalizes to sites of genomic instability, resulting in the desilencing of ... | SIRT1 Redistribution on Chromatin Promotes Genomic Stability but Alters Gene Expression during Aging |
{"1014": 0.49982786178588867, "1016": 0.009718249551951885, "1044": 0.41389304399490356, "1056": 0.6892333030700684, "1061": 0.15023678541183472, "2005": 0.06429435312747955, "2026": 0.04674193635582924, "2044": 0.4248080551624298, "2058": 0.1358480453491211, "2062": 0.1946154683828354, "2075": 0.0752234235405922, "209... | 5824985 | BACKGROUND Bariatric surgery is becoming a more widespread treatment for obesity. Comprehensive evidence of the long-term effects of contemporary surgery on a broad range of clinical outcomes in large populations treated in routine clinical practice is lacking. The objective of this study was to measure the association... | Bariatric Surgery in the United Kingdom: A Cohort Study of Weight Loss and Clinical Outcomes in Routine Clinical Care. |
{"1015": 0.3163207769393921, "1017": 0.07793712615966797, "1019": 0.03925827145576477, "1996": 0.09761575609445572, "1999": 0.09938567131757736, "2007": 0.10026945173740387, "2008": 0.02316705882549286, "2010": 0.06246116757392883, "2012": 0.2145126610994339, "2026": 1.0172666311264038, "2028": 0.07612881064414978, "20... | 5828251 | During Drosophila myogenesis, Notch signalling acts at multiple steps of the muscle differentiation process. In vertebrates, Notch activation has been shown to block MyoD activation and muscle differentiation in vitro, suggesting that this pathway may act to maintain the cells in an undifferentiated proliferative state... | Notch signalling acts in postmitotic avian myogenic cells to control MyoD activation. |
{"1014": 0.43875885009765625, "1020": 0.11604541540145874, "1038": 0.45623743534088135, "1039": 0.9131608605384827, "1041": 0.07068414986133575, "1044": 0.5540198087692261, "1052": 0.3784096837043762, "1058": 0.04487626627087593, "2001": 0.12986256182193756, "2002": 1.1561684608459473, "2010": 0.3034266233444214, "2014... | 5835149 | OBJECTIVE To determine the prevalence and risk factors for hepatitis C virus (HCV) infection in a cohort of homosexually active men, with particular reference to assessing sexual transmission. DESIGN Prevalence based on cross-sectional testing for HCV (c100 protein) antibody in a cohort using sera stored between 1984 a... | Hepatitis C virus infection in a large cohort of homosexually active men: independent associations with HIV-1 infection and injecting drug use but not sexual behaviour. |
{"1011": 0.2741633653640747, "1016": 0.021256839856505394, "1043": 0.23479416966438293, "2004": 0.11951763927936554, "2005": 0.15526613593101501, "2008": 0.15023678541183472, "2011": 0.3464667797088623, "2015": 0.3027053773403168, "2024": 0.13499516248703003, "2029": 0.32058215141296387, "2048": 0.5751199722290039, "20... | 5838067 | MicroRNAs (miRNAs) are expressed in a wide variety of organisms, ranging from plants to animals, and are key posttranscriptional regulators of gene expression. Virally encoded miRNAs are unique in that they could potentially target both viral and host genes. Indeed, we have previously demonstrated that a human cytomega... | Analysis of human cytomegalovirus-encoded microRNA activity during infection. |
{"1011": 0.14686977863311768, "1015": 0.6970458030700684, "1043": 0.9279413223266602, "1044": 0.07159364968538284, "1052": 0.3269403576850891, "1061": 0.6296497583389282, "2002": 0.5805994272232056, "2005": 0.2184450328350067, "2008": 0.151916041970253, "2011": 0.11691460013389587, "2015": 0.10203468054533005, "2019": ... | 5839365 | The ideal anti-obesity drug would produce sustained weight loss with minimal side effects. The mechanisms that regulate energy balance have substantial built-in redundancy, overlap considerably with other physiological functions, and are influenced by social, hedonic and psychological factors that limit the effectivene... | Anti-obesity drugs: past, present and future |
{"1017": 0.19622190296649933, "1038": 0.8525851964950562, "1055": 0.2711893916130066, "1997": 0.06429435312747955, "1999": 0.13157635927200317, "2008": 0.13157635927200317, "2011": 0.2990913391113281, "2013": 0.16524957120418549, "2020": 0.03831886500120163, "2029": 0.2741633653640747, "2034": 0.34370049834251404, "203... | 5849439 | Microsporogenesis has been examined in wild-type Arabidopsis thaliana and the nuclear male-sterile mutant BM3 by cytochemical staining. The mutant lacks adenine phosphoribosyltransferase, an enzyme of the purine salvage pathway that converts adenine to AMP. Pollen development in the mutant began to diverge from wild ty... | Cytochemical Analysis of Pollen Development in Wild-Type Arabidopsis and a Male-Sterile Mutant. |
{"1003": 0.3191637098789215, "1008": 0.1401015669107437, "1014": 0.2689530849456787, "1018": 0.12986256182193756, "1020": 0.03925827145576477, "1022": 0.056018441915512085, "1062": 0.09938567131757736, "2001": 0.14095009863376617, "2005": 0.21214580535888672, "2014": 0.08961215615272522, "2015": 0.030771657824516296, "... | 5850219 | BACKGROUND Population-based estimates of prevalence, risk distribution, and intervention uptake inform delivery of control programmes for sexually transmitted infections (STIs). We undertook the third National Survey of Sexual Attitudes and Lifestyles (Natsal-3) after implementation of national sexual health strategies... | Prevalence, risk factors, and uptake of interventions for sexually transmitted infections in Britain: findings from the National Surveys of Sexual Attitudes and Lifestyles (Natsal) |
{"1043": 0.31845372915267944, "1050": 0.0058422754518687725, "1052": 0.08692999184131622, "1998": 0.2822965085506439, "2000": 0.053244512528181076, "2011": 0.0752234235405922, "2040": 0.01934296265244484, "2043": 0.16607704758644104, "2046": 0.4709797203540802, "2047": 0.2711893916130066, "2070": 0.10993985831737518, "... | 5855168 | Recent advances in genomic research have demonstrated a substantial role for genomic factors in predicting response to cancer therapies. Researchers in the fields of cancer pharmacogenomics and pharmacoepidemiology seek to understand why individuals respond differently to drug therapy, in terms of both adverse effects ... | Cancer Pharmacogenomics and Pharmacoepidemiology: Setting a Research Agenda to Accelerate Translation |
{"1011": 0.10731173306703568, "1015": 0.1401015669107437, "1050": 0.18978065252304077, "1054": 0.7951818704605103, "2002": 0.6911921501159668, "2005": 0.08154398202896118, "2007": 0.09850110858678818, "2008": 0.06246116757392883, "2011": 0.3870677351951599, "2013": 0.05694137513637543, "2024": 0.15860503911972046, "202... | 5860364 | An important model system for studying the process leading to productive transcription is provided by the superfamily of nuclear receptors, which are for the most part ligand-controlled transcription factors. Over the past years several 'orphan' nuclear receptors have been isolated for which no ligand has yet been iden... | Differential transcription of the orphan receptor RORbeta in nuclear extracts derived from Neuro2A and HeLa cells. |
{"1017": 0.009718249551951885, "1042": 0.3325583338737488, "1051": 0.49030399322509766, "1998": 0.2954642176628113, "2006": 0.3750596046447754, "2007": 0.16276304423809052, "2012": 0.09050461649894714, "2025": 0.06703783571720123, "2029": 0.029824240133166313, "2035": 0.319873183965683, "2044": 0.055094651877880096, "2... | 5864770 | Epidemiologic studies suggest that ovarian hormones contribute to the development of breast cancer at all stages. Early menopause and premenopausal obesity reduces the risk while postmenopausal obesity and menopausal estrogen replacement therapy increases the risk. Combined oral contraceptives and Depo-Provera do not r... | Estrogens, progestogens, normal breast cell proliferation, and breast cancer risk. |
{"1011": 0.3526630103588104, "1015": 0.8433839678764343, "1044": 0.8332487344741821, "1045": 0.20102575421333313, "1048": 0.013579257763922215, "1056": 0.9256220459938049, "1998": 0.22392450273036957, "1999": 0.18329764902591705, "2002": 0.2763880789279938, "2004": 0.056018441915512085, "2007": 0.40351006388664246, "20... | 5867846 | The question of whether retroviruses, including human immunodeficiency virus type 1 (HIV-1), interact with the cellular RNA interference machinery has been controversial. Here, we present data showing that neither HIV-1 nor human T-cell leukemia virus type 1 (HTLV-1) expresses significant levels of either small interfe... | Analysis of the interaction of primate retroviruses with the human RNA interference machinery. |
{"1014": 0.3757305145263672, "1016": 0.09406650811433792, "1052": 0.24171993136405945, "1053": 0.8796916007995605, "1998": 0.0009760859538801014, "1999": 0.3963087201118469, "2001": 0.0019512200960889459, "2004": 0.3177432417869568, "2007": 0.5370414853096008, "2018": 0.21687394380569458, "2020": 0.10731173306703568, "... | 5884524 | BACKGROUND Although unstable coronary artery disease is the most common reason for admission to a coronary care unit, the long-term prognosis of patients with this diagnosis is unknown. This is particularly true for patients with diabetes mellitus, who are known to have a high morbidity and mortality after an acute myo... | Impact of diabetes on long-term prognosis in patients with unstable angina and non-Q-wave myocardial infarction: results of the OASIS (Organization to Assess Strategies for Ischemic Syndromes) Registry. |
{"1043": 0.5685047507286072, "1048": 0.6128603219985962, "1997": 0.12384103983640671, "2003": 0.014542185701429844, "2042": 0.06886265426874161, "2054": 0.26296505331993103, "2064": 0.09317722171545029, "2079": 0.13414156436920166, "2083": 0.11865071207284927, "2109": 0.3012613356113434, "2166": 0.1751343309879303, "21... | 5885376 | A central goal of systems biology is the elucidation of cell function and physiology through the integrated use of broad based genomic and physiological data. Such systemic approaches have been employed extensively in the past, as they are a central element of metabolic flux analysis, the distribution of kinetic contro... | Strain improvement by metabolic engineering: lysine production as a case study for systems biology. |
{"1020": 0.3949938118457794, "1050": 0.06612417846918106, "1062": 1.04512357711792, "2001": 0.0029254043474793434, "2003": 0.3750596046447754, "2005": 0.12038381397724152, "2007": 0.006812678650021553, "2041": 0.1332872211933136, "2051": 0.613389253616333, "2062": 0.06246116757392883, "2076": 0.33675122261047363, "2080... | 5912283 | CONTEXT Insomnia is a common condition in older adults and is associated with a number of adverse medical, social, and psychological consequences. Previous research has suggested beneficial outcomes of both psychological and pharmacological treatments, but blinded placebo-controlled trials comparing the effects of thes... | Cognitive behavioral therapy vs zopiclone for treatment of chronic primary insomnia in older adults: a randomized controlled trial. |
{"1011": 0.1619328260421753, "1017": 0.42353010177612305, "1039": 0.08154398202896118, "1049": 0.10467668622732162, "1056": 1.0492360591888428, "1062": 0.53589928150177, "1160": 1.2192846536636353, "1996": 0.12384103983640671, "1997": 0.05417001247406006, "1998": 0.0317181795835495, "2006": 0.020300358533859253, "2007"... | 5914739 | The CD3ε and ζ cytoplasmic domains of the T cell receptor bind to the inner leaflet of the plasma membrane (PM), and a previous nuclear magnetic resonance structure showed that both tyrosines of the CD3ε immunoreceptor tyrosine-based activation motif partition into the bilayer. Electrostatic interactions between acidic... | Local changes in lipid environment of TCR microclusters regulate membrane binding by the CD3ε cytoplasmic domain |
{"1996": 0.4818955361843109, "2001": 0.07341018319129944, "2013": 0.08244366943836212, "2018": 0.09850110858678818, "2020": 0.2763880789279938, "2025": 0.004870930220931768, "2029": 0.22937409579753876, "2031": 0.21765978634357452, "2035": 0.05970508232712746, "2037": 0.06154331564903259, "2038": 0.037378571927547455, ... | 5921065 | Some of the outstanding cognitive capabilities of humans are commonly attributed to a disproportionate enlargement of the human frontal lobe during evolution. This claim is based primarily on comparisons between the brains of humans and of other primates, to the exclusion of most great apes. We compared the relative si... | Humans and great apes share a large frontal cortex |
{"1011": 0.1693800985813141, "1040": 0.3743882179260254, "1055": 0.18329764902591705, "1998": 0.17840765416622162, "2002": 0.0029254043474793434, "2007": 0.09317722171545029, "2011": 0.15359249711036682, "2012": 0.7086513638496399, "2029": 0.012615402229130268, "2035": 0.6054253578186035, "2064": 0.21922965347766876, "... | 5922085 | It is unclear why disease occurs in only a small proportion of persons carrying common risk alleles of disease susceptibility genes. Here we demonstrate that an interaction between a specific virus infection and a mutation in the Crohn's disease susceptibility gene Atg16L1 induces intestinal pathologies in mice. This v... | Virus-Plus-Susceptibility Gene Interaction Determines Crohn's Disease Gene Atg16L1 Phenotypes in Intestine |
{"1006": 0.07159364968538284, "1009": 0.8039615154266357, "1011": 0.1905880719423294, "1016": 0.347847044467926, "1043": 0.417115718126297, "1047": 0.06795065850019455, "1996": 0.06795065850019455, "2005": 0.11691460013389587, "2008": 0.16110190749168396, "2012": 0.28155985474586487, "2029": 0.3526630103588104, "2043":... | 5927534 | The Ca(2+)/calmodulin-dependent protein kinase II (CaMKII) is critically required for the synaptic recruitment of AMPA-type glutamate receptors (AMPARs) during both development and plasticity. However, the underlying mechanism is unknown. Using single-particle tracking of AMPARs, we show that CaMKII activation and post... | CaMKII Triggers the Diffusional Trapping of Surface AMPARs through Phosphorylation of Stargazin |
{"2011": 0.1693800985813141, "2045": 0.19782574474811554, "2057": 0.17431432008743286, "2064": 0.08064348995685577, "2071": 0.15693697333335876, "2075": 0.009718249551951885, "2079": 0.0038986403960734606, "2099": 0.09672962874174118, "2110": 0.28670501708984375, "2129": 0.23479416966438293, "2177": 0.4419025182723999,... | 5935987 | When it comes to the epigenome, there is a fine line between clarity and confusion-walk that line and you will discover another fascinating level of transcription control. With the genetic code representing the cornerstone of rules for information that is encoded to proteins somewhere above the genome level there is a ... | Epigenetics in diabetic nephropathy, immunity and metabolism |
{"1020": 0.07068414986133575, "1022": 0.06977381557226181, "1023": 0.1358480453491211, "1044": 0.0029254043474793434, "1997": 0.045809537172317505, "1998": 0.41195443272590637, "2004": 0.47158926725387573, "2007": 0.17840765416622162, "2035": 0.5952457785606384, "2038": 0.08782484382390976, "2042": 0.2622140049934387, ... | 5939172 | PURPOSE To analyze the relationship between an aspect of drinking pattern (i.e., drinking with or without meals) and risk of all-cause and specific-cause mortality. METHODS The Risk Factors and Life Expectancy Study, is a pooling of a series of epidemiological studies conducted in Italy. Eight-thousand six-hundred and ... | Drinking pattern and mortality: the Italian Risk Factor and Life Expectancy pooling project. |
{"1052": 0.47402387857437134, "2003": 0.2223619967699051, "2029": 0.10906458646059036, "2033": 0.34922540187835693, "2047": 0.13670019805431366, "2361": 1.3290210962295532, "2458": 0.6634125709533691, "2470": 0.2561853528022766, "2535": 0.018384648486971855, "2599": 0.4580921530723572, "2649": 0.006812678650021553, "26... | 5944514 | Planar cell polarity (PCP) is observed in an array of developmental processes that involve collective cell movement and tissue organization, and its disruption can lead to severe developmental defects. Recent studies in flies and vertebrates have identified new functions for PCP as well as new signalling components, an... | Pointing in the right direction: new developments in the field of planar cell polarity |
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