spalde-v3-lexical stringlengths 4.95k 41.3k | _id stringlengths 4 9 | text stringlengths 174 10k | title stringlengths 2 300 |
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{"1011": 0.21372433006763458, "1015": 0.16110190749168396, "1058": 0.4950772523880005, "1999": 0.49626702070236206, "2006": 0.4248080551624298, "2007": 0.3423145115375519, "2008": 0.10291612148284912, "2011": 0.3464667797088623, "2024": 0.11604541540145874, "2029": 0.21135559678077698, "2046": 0.2247048318386078, "2072... | 5953485 | Adenosine deaminases acting on RNA (ADARs) are involved in RNA editing that converts adenosine residues to inosine specifically in double-stranded RNAs. In this study, we investigated the interaction of the RNA editing mechanism with the RNA interference (RNAi) machinery and found that ADAR1 forms a complex with Dicer ... | ADAR1 Forms a Complex with Dicer to Promote MicroRNA Processing and RNA-Induced Gene Silencing |
{"1038": 0.28450319170951843, "1998": 0.10467668622732162, "2003": 0.1477125883102417, "2005": 0.176772341132164, "2007": 0.08782484382390976, "2015": 0.28963330388069153, "2022": 0.016465263441205025, "2025": 0.1619328260421753, "2042": 0.18411032855510712, "2045": 0.05786345899105072, "2048": 0.4196864068508148, "205... | 5956016 | Many of the best-selling ‘blockbuster’ biological medicinal products are, or will soon be, facing competition from similar biological medicinal products (biosimilars) in the EU. Biosimilarity is based on the comparability concept, which has been used successfully for several decades to ensure close similarity of a biol... | Interchangeability of Biosimilars: A European Perspective |
{"1015": 0.3903779089450836, "1043": 0.8699195384979248, "1048": 0.053244512528181076, "1052": 0.6139179468154907, "1056": 0.5301685929298401, "1996": 0.037378571927547455, "2008": 0.05139094591140747, "2012": 0.3191637098789215, "2028": 0.03925827145576477, "2029": 0.129004567861557, "2061": 0.6466736793518066, "2073"... | 5956380 | Gliomas arising in the brainstem and thalamus are devastating tumors that are difficult to surgically resect. To determine the genetic and epigenetic landscape of these tumors, we performed exomic sequencing of 14 brainstem gliomas (BSGs) and 12 thalamic gliomas. We also performed targeted mutational analysis of an add... | Exome sequencing identifies somatic gain-of-function PPM1D mutations in brainstem gliomas |
{"1011": 0.11865071207284927, "1016": 0.06795065850019455, "1020": 0.304147332906723, "1022": 0.12556517124176025, "1044": 0.8195732831954956, "1062": 1.034073829650879, "1997": 0.1229778528213501, "1999": 0.13499516248703003, "2002": 0.24631060659885406, "2007": 0.45251765847206116, "2008": 0.053244512528181076, "2010... | 5966635 | Activation of transcription within chromatin has been correlated with the incorporation of the essential histone variant H2A.Z into nucleosomes. H2A.Z and other histone variants may establish structurally distinct chromosomal domains; however, the molecular mechanism by which they function is largely unknown. Here we r... | Crystal structure of a nucleosome core particle containing the variant histone H2A.Z |
{"1011": 0.006812678650021553, "1040": 0.22859740257263184, "1047": 1.0066169500350952, "1056": 0.8332487344741821, "1999": 0.0317181795835495, "2007": 0.07612881064414978, "2011": 0.3995884954929352, "2012": 0.6155022978782654, "2015": 0.848413348197937, "2029": 0.23247487843036652, "2046": 0.25088030099868774, "2063"... | 5979056 | Dendritic cells (DCs) have been implicated as important regulators of innate and adaptive inflammation in many diseases, including atherosclerosis. However, the molecular mechanisms by which DCs mitigate or promote inflammatory pathogenesis are only partially understood. Previous studies have shown an important anti-in... | Dendritic Cell KLF2 Expression Regulates T Cell Activation and Proatherogenic Immune Responses. |
{"1011": 0.0842406153678894, "1015": 0.41389304399490356, "1018": 0.2969166338443756, "1038": 0.4818955361843109, "1043": 0.26146242022514343, "1056": 0.6389714479446411, "2005": 0.42225050926208496, "2007": 0.2231435477733612, "2014": 0.6275664567947388, "2028": 0.11604541540145874, "2029": 0.08961215615272522, "2047"... | 5991309 | With the success of ipilimumab and promise of programmed death-1 pathway-targeted agents, the field of tumor immunotherapy is expanding rapidly. Newer targets for clinical development include select members of the tumor necrosis factor receptor (TNFR) family. Agonist antibodies to these co-stimulatory molecules target ... | Targeting tumor-necrosis factor receptor pathways for tumor immunotherapy |
{"1014": 0.2607102394104004, "1017": 0.12642613053321838, "1039": 0.14518201351165771, "1044": 0.47463157773017883, "1050": 0.3923587501049042, "1052": 0.36426326632499695, "1999": 0.3141832649707794, "2003": 0.22937409579753876, "2004": 0.13925230503082275, "2013": 0.03266380727291107, "2026": 0.4879087805747986, "202... | 5993745 | BACKGROUND Corin is a transmembrane protease that processes natriuretic peptides in the heart. Like many membrane proteins, corin is shed from the cell surface. METHODS AND RESULTS In this study, we obtained plasma samples from healthy controls and patients with heart failure (HF) and acute myocardial infarction. Solub... | Plasma soluble corin in patients with heart failure. |
{"1011": 0.06246116757392883, "1017": 0.052318159490823746, "1052": 0.3519764244556427, "1055": 0.43244171142578125, "1156": 0.4462870955467224, "1999": 0.4286321699619293, "2008": 0.022212404757738113, "2011": 0.35334911942481995, "2015": 0.9256220459938049, "2026": 1.0087559223175049, "2029": 0.2223619967699051, "203... | 6000423 | Despite genetic heterogeneity, myelodysplastic syndromes (MDSs) share features of cytological dysplasia and ineffective hematopoiesis. We report that a hallmark of MDSs is activation of the NLRP3 inflammasome, which drives clonal expansion and pyroptotic cell death. Independent of genotype, MDS hematopoietic stem and p... | The NLRP3 inflammasome functions as a driver of the myelodysplastic syndrome phenotype. |
{"1039": 0.2659635543823242, "1059": 0.3005385100841522, "1996": 0.013579257763922215, "2005": 0.08603433519601822, "2050": 0.4891071021556854, "2061": 0.5261374711990356, "2064": 0.037378571927547455, "2079": 0.255429208278656, "2086": 0.013579257763922215, "2090": 0.1229778528213501, "2102": 0.6181373596191406, "2106... | 6036535 | BACKGROUND There is no doubt that good bimanual performance is very important for skilled handball playing. The control of the non-dominant hand is especially demanding since efficient catching and throwing needs both hands. METHODOLOGY/HYPOTHESES We investigated training-induced structural neuroplasticity in professio... | Structural Brain Correlates Associated with Professional Handball Playing |
{"1041": 0.058784693479537964, "2015": 0.3897167444229126, "2022": 0.040196798741817474, "2028": 0.09938567131757736, "2045": 0.29619070887565613, "2064": 0.3027053773403168, "2076": 0.5427330136299133, "2079": 0.20818853378295898, "2109": 0.11430477350950241, "2112": 0.06612417846918106, "2135": 0.12642613053321838, "... | 6040392 | The role of epigenetics in aging and age-related diseases is a key issue in molecular physiology and medicine because certain epigenetic factors are thought to mediate, at least in part, the relationship between the genome and the environment. An active role for epigenetics in aging must meet two prior conditions: ther... | The role of epigenetics in aging and age-related diseases |
{"1018": 0.18492233753204346, "1022": 0.2719337046146393, "1023": 0.175953671336174, "1044": 0.38174858689308167, "1048": 0.3499138653278351, "1051": 0.6338034868240356, "1059": 0.7629209756851196, "1998": 0.2089812457561493, "1999": 0.1619328260421753, "2007": 0.2231435477733612, "2010": 0.8135309815406799, "2012": 0.... | 6042706 | The links between obesity in parents and their offspring and the role of genes and a shared environment are not completely understood. Adipocytokines such as leptin and adiponectin play important roles in glucose and lipid metabolism. Therefore, we examined whether the offspring from dams exposed to a high-fat diet dur... | Effects of a high-fat diet exposure in utero on the metabolic syndrome-like phenomenon in mouse offspring through epigenetic changes in adipocytokine gene expression. |
{"1011": 0.2674594223499298, "1021": 0.08154398202896118, "1047": 0.565735399723053, "1999": 0.011650617234408855, "2000": 0.19541899859905243, "2008": 0.06246116757392883, "2026": 0.777387797832489, "2029": 0.35745587944984436, "2046": 0.11256109178066254, "2061": 0.8957691192626953, "2062": 0.2576959431171417, "2064"... | 6054657 | Transcription factor-based cellular reprogramming has opened the way to converting somatic cells to a pluripotent state, but has faced limitations resulting from the requirement for transcription factors and the relative inefficiency of the process. We show here that expression of the miR302/367 cluster rapidly and eff... | Highly efficient miRNA-mediated reprogramming of mouse and human somatic cells to pluripotency. |
{"1003": 0.17922431230545044, "1011": 0.1685553640127182, "1014": 0.2026219218969345, "1023": 0.06977381557226181, "1040": 0.2478361576795578, "1052": 0.5882205963134766, "1054": 0.38041436672210693, "1997": 0.0029254043474793434, "2007": 0.38905516266822815, "2012": 0.37707099318504333, "2015": 0.36967599391937256, "2... | 6057195 | AIMS The aims of this analysis were to examine levels of unmet needs and depression among carers of people newly diagnosed with cancer and to identify groups who may be at higher risk, by examining relationships with demographic characteristics. METHODS One hundred and fifty dyads of people newly diagnosed with cancer ... | Unmet needs and depression among carers of people newly diagnosed with cancer. |
{"1009": 0.2830325961112976, "1011": 0.46424978971481323, "1015": 0.9052929878234863, "1016": 0.5347557663917542, "1043": 1.19829261302948, "1047": 0.5629584193229675, "1048": 1.1018621921539307, "2003": 0.3005385100841522, "2005": 0.04953393340110779, "2008": 0.18167030811309814, "2011": 0.38041436672210693, "2013": 0... | 6061927 | Glucagon-like peptide-1 (GLP-1) is an enteric hormone that stimulates insulin secretion and improves glycaemia in type 2 diabetes. Although GLP-1-based treatments are clinically available, alternative strategies to increase endogenous GLP-1 release from L cells are hampered by our limited physiological understanding of... | Glucose Sensing in L Cells: A Primary Cell Study |
{"1014": 0.38041436672210693, "1022": 0.11778303235769272, "1052": 0.32553088665008545, "1056": 0.040196798741817474, "1999": 0.083342544734478, "2012": 0.5729197263717651, "2015": 1.0271050930023193, "2026": 0.371698260307312, "2086": 0.4126010537147522, "2090": 0.07068414986133575, "2146": 0.2659635543823242, "2179":... | 6070278 | OBJECTIVE The purpose of the present study was to investigate the relationship between the Total Atherosclerotic Score (TAS), a measurement of the overall atherosclerotic burden of the arterial tree by whole body magnetic resonance angiography (WBMRA), and the risk of major adverse cardiovascular events (MACE), defined... | Total atherosclerotic burden by whole body magnetic resonance angiography predicts major adverse cardiovascular events. |
{"1011": 0.15610189735889435, "1016": 0.009718249551951885, "1018": 0.4818955361843109, "1021": 0.6022219061851501, "1038": 0.8731874823570251, "1060": 0.7755908370018005, "1996": 0.09584271162748337, "1998": 0.0354953333735466, "2010": 0.623910129070282, "2011": 0.27712854743003845, "2012": 0.16690383851528168, "2015"... | 6076903 | Embryos have the ability to self-regulate and regenerate normal structures after being sectioned in half. How is such a morphogenetic field established? We discovered that quadruple knockdown of ADMP and BMP2/4/7 in Xenopus embryos eliminates self-regulation, causing ubiquitous neural induction throughout the ectoderm.... | Regulation of ADMP and BMP2/4/7 at Opposite Embryonic Poles Generates a Self-Regulating Morphogenetic Field |
{"2000": 0.2561853528022766, "2003": 0.02316705882549286, "2005": 0.2637155055999756, "2047": 0.21214580535888672, "2060": 0.02316705882549286, "2064": 0.4151833653450012, "2071": 0.06246116757392883, "2075": 0.03925827145576477, "2079": 0.2493593990802765, "2089": 0.09672962874174118, "2098": 0.03925827145576477, "210... | 6077214 | Genetics can potentially provide new, species-specific, environmentally friendly methods for mosquito control. Genetic control strategies aim either to suppress target populations or to introduce a harm-reducing novel trait. Different approaches differ considerably in their properties, especially between self-limiting ... | Genetic control of mosquitoes. |
{"1003": 0.09672962874174118, "1014": 0.5495203733444214, "1052": 0.6533012986183167, "2006": 0.8600510358810425, "2012": 0.3443928062915802, "2013": 0.175953671336174, "2029": 0.15275461971759796, "2061": 0.8583967685699463, "2062": 0.2576959431171417, "2070": 0.07341018319129944, "2071": 0.029824240133166313, "2075":... | 6078882 | It has been demonstrated for some cancers that the frequency of somatic oncogenic mutations may vary in ancestral populations. To determine whether key driver alterations might occur at different frequencies in colorectal cancer, we applied a high-throughput genotyping platform (OncoMap) to query 385 mutations across 3... | Colorectal Cancers from Distinct Ancestral Populations Show Variations in BRAF Mutation Frequency |
{"1054": 0.0913962796330452, "1996": 0.00875066313892603, "2042": 0.10818854719400406, "2046": 0.319873183965683, "2064": 0.255429208278656, "2067": 0.19782574474811554, "2071": 0.0029254043474793434, "2075": 0.12038381397724152, "2076": 0.49626702070236206, "2079": 0.18329764902591705, "2089": 0.1332872211933136, "210... | 6079486 | The key signalling pathways and transcriptional programmes that instruct neuronal diversity during development have largely been identified. In this Review, we discuss how this knowledge has been used to successfully reprogramme various cell types into an amazing array of distinct types of functional neurons. We furthe... | Direct neuronal reprogramming: learning from and for development. |
{"1037": 0.037378571927547455, "1039": 0.7537717819213867, "2003": 0.06795065850019455, "2011": 0.021256839856505394, "2024": 0.18492233753204346, "2054": 0.08064348995685577, "2064": 0.09672962874174118, "2066": 0.6522845029830933, "2079": 0.1602703034877777, "2083": 0.19782574474811554, "2090": 0.31132611632347107, "... | 6082738 | A major advance in recent cancer research is the identification of tumor cells with stem cell-like properties. Cancer stem cells (CSCs) often represent a rare population in the tumor mass and possess the exclusive ability to initiate the growth of a heterogeneous tumor. The origin of CSCs remains elusive and is likely ... | Cell fusion hypothesis of the cancer stem cell. |
{"1011": 0.03831886500120163, "1017": 0.176772341132164, "1040": 0.11081436276435852, "1043": 0.6548244953155518, "1048": 0.6553317308425903, "1049": 0.09050461649894714, "1052": 0.5186077356338501, "1999": 0.16442140936851501, "2006": 0.04487626627087593, "2007": 0.06886265426874161, "2011": 0.22626367211341858, "2021... | 6083952 | 1. Incubation of LMCAT fibroblast cells with antidepressants potentiates glucocorticoid receptor (GR)-mediated gene transcription in the presence of dexamethasone and cortisol, but not of corticosterone. We have shown that antidepressants do so by inhibiting the LMCAT cell membrane steroid transporter (which is virtual... | Antidepressant fluoxetine enhances glucocorticoid receptor function in vitro by modulating membrane steroid transporters. |
{"1003": 0.03925827145576477, "1013": 0.23092569410800934, "1039": 0.14264501631259918, "1043": 0.7096124291419983, "1050": 0.4673144817352295, "1052": 0.12038381397724152, "1999": 0.10731173306703568, "2004": 0.04860413447022438, "2015": 0.1693800985813141, "2020": 0.20022670924663544, "2026": 0.49864232540130615, "20... | 6085365 | BACKGROUND Few studies have examined whether physician knowledge, attitudes, or practice patterns might contribute to gender disparities in the primary prevention of coronary heart disease (CHD), including among physicians caring for the largest number of reproductive-age women, obstetricians and gynecologists (OB/GYNs... | Physician knowledge levels and barriers to coronary risk prevention in women: survey results from the Women and Heart Disease Physician Education Initiative. |
{"1037": 0.12556517124176025, "1055": 0.4879087805747986, "1998": 0.04113444685935974, "2000": 0.10203468054533005, "2003": 0.10993985831737518, "2004": 0.7629209756851196, "2005": 0.04487626627087593, "2011": 0.39762192964553833, "2013": 0.20660123229026794, "2034": 0.2089812457561493, "2051": 0.08154398202896118, "20... | 6106004 | Publisher Summary The budding yeast Saccharomyces cerevisiae ( S. cerevisiae ) divides asymmetrically. In vegetative growth, yeast cells reproduce by budding, and the position where the bud forms ultimately determines the plane of cell division. This chapter describes the detailed procedures for the separation and isol... | Separation of mother and daughter cells. |
{"1051": 0.0842406153678894, "2004": 0.33675122261047363, "2010": 0.7352184057235718, "2029": 0.08603433519601822, "2042": 0.058784693479537964, "2043": 0.42608439922332764, "2046": 0.08871890604496002, "2047": 0.7124901413917542, "2051": 0.3423145115375519, "2064": 0.3070250153541565, "2076": 0.21922965347766876, "207... | 6108481 | It has been shown by several investigators that adipocyte number is stable in mature human beings and several species of rodents. Although the number of new cells appearing in the adipose depot can be measured histometrically and by Coulter counting of osmium-fixed cells, such methods do not distinguish between "lipid ... | Postnatal development of adipocyte cellularity in the normal rat. |
{"1054": 0.012615402229130268, "1055": 0.056018441915512085, "2000": 0.007782140281051397, "2003": 0.004870930220931768, "2004": 0.15526613593101501, "2007": 0.3864043951034546, "2011": 0.08244366943836212, "2024": 0.083342544734478, "2042": 0.2026219218969345, "2045": 0.040196798741817474, "2050": 0.45870962738990784,... | 6112053 | Background: Selective serotonin reuptake inhibitors (SSRI) are widely used in medical practice. They have been associated with a broad range of symptoms, whose clinical meaning has not been fully appreciated. Methods: The PRISMA guidelines were followed to conduct a systematic review of the literature. Titles, abstract... | Withdrawal Symptoms after Selective Serotonin Reuptake Inhibitor Discontinuation: A Systematic Review |
{"1011": 0.15359249711036682, "1015": 0.5127768516540527, "1016": 0.020300358533859253, "1017": 0.15943801403045654, "1040": 0.058784693479537964, "1043": 0.669430673122406, "1047": 0.13071982562541962, "2011": 0.4158279001712799, "2028": 0.2018241584300995, "2029": 0.3519764244556427, "2033": 0.28743788599967957, "205... | 6121555 | The aim of this study was to investigate the mechanism through which Sphingosine kinase-1 (SPHK1) exerts its anti-apoptosis activity in glioma cancer cells. We here report that dysregulation of SPHK1 alters the sensitivity of glioma to apoptosis both in vitro and in vivo. Further mechanistic study examined the expressi... | Sphingosine Kinase 1 Regulates the Akt/FOXO3a/Bim Pathway and Contributes to Apoptosis Resistance in Glioma Cells |
{"1011": 0.38374659419059753, "1014": 0.4067663550376892, "1016": 0.6659244894981384, "1028": 0.23556606471538544, "1048": 0.3034266233444214, "1052": 0.6970458030700684, "1054": 0.42096930742263794, "1998": 0.2516399025917053, "2004": 0.1332872211933136, "2007": 0.4400174915790558, "2026": 0.31132611632347107, "2029":... | 6121668 | OBJECTIVES To investigate the expressions of survivin and Cyclooxygenase-2 (COX-2), and their possible correlations in the development of endometrial adenocarcinoma (EC). We also looked at their association with classical prognostic factors in EC. To our knowledge, this is the first time survivin expression is investig... | COX-2 and survivin are overexpressed and positively correlated in endometrial carcinoma. |
{"1043": 0.5811457633972168, "1996": 0.22859740257263184, "1997": 0.15023678541183472, "1999": 0.02316705882549286, "2011": 0.12642613053321838, "2012": 0.5393219590187073, "2013": 0.052318159490823746, "2035": 1.0901126861572266, "2044": 0.176772341132164, "2048": 0.06612417846918106, "2050": 0.3601844012737274, "2054... | 6123521 | The brain interprets experiences and translates them into behavioral and physiological responses. Stressful events are those which are threatening or, at the very least, unexpected and surprising, and the physiological and behavioral responses are intended to promote adaptation via a process called "allostasis. " Chemi... | Structural plasticity of the adult brain: how animal models help us understand brain changes in depression and systemic disorders related to depression |
{"1009": 0.6563454270362854, "1011": 0.4920966327190399, "1016": 0.7408206462860107, "1017": 0.07068414986133575, "1020": 0.09317722171545029, "1056": 1.0580886602401733, "2011": 0.32129061222076416, "2029": 0.24325250089168549, "2048": 0.3883931338787079, "2079": 0.3949938118457794, "2083": 0.09584271162748337, "2090"... | 6123924 | Immune tolerance and activation depend on precise control over the number and function of immunosuppressive Foxp3(+) regulatory T (T reg) cells, and the importance of IL-2 in maintaining tolerance and preventing autoimmunity is clear. However, the homeostatic requirement for IL-2 among specific populations of periphera... | CCR7 provides localized access to IL-2 and defines homeostatically distinct regulatory T cell subsets |
{"1011": 0.43623676896095276, "1041": 0.6902132034301758, "1042": 0.4067663550376892, "1046": 0.4770587682723999, "1047": 0.3777405619621277, "1052": 0.3622259199619293, "1054": 0.18329764902591705, "1055": 0.30989447236061096, "1056": 0.3170322775840759, "1059": 0.1994270235300064, "1997": 0.15442965924739838, "2007":... | 6128334 | Pairwise sequence comparison methods have been assessed using proteins whose relationships are known reliably from their structures and functions, as described in the SCOP database [Murzin, A. G., Brenner, S. E., Hubbard, T. & Chothia C. (1995) J. Mol. Biol. 247, 536-540]. The evaluation tested the programs BLAST [Alts... | Assessing sequence comparison methods with reliable structurally identified distant evolutionary relationships. |
{"1049": 1.1708117723464966, "1998": 0.04953393340110779, "2001": 0.16359257698059082, "2003": 0.1602703034877777, "2005": 0.04487626627087593, "2020": 0.08603433519601822, "2033": 0.18654440343379974, "2037": 0.02887592278420925, "2040": 0.11691460013389587, "2053": 0.0019512200960889459, "2106": 0.021256839856505394,... | 6129301 | AIMS To describe the characteristics of homeless children and families seen by the mental health outreach service (MHOS), to evaluate the impact of this service on the short term psychosocial functioning of children and parents, and to establish perceptions of, and satisfaction with, the service. METHODS Twenty seven c... | Evaluation of a mental health outreach service for homeless families. |
{"1022": 0.2830325961112976, "1052": 0.6086184978485107, "1609": 0.11256109178066254, "2000": 0.3615458607673645, "2005": 0.2741633653640747, "2007": 0.3353555500507355, "2022": 0.013579257763922215, "2064": 0.01934296265244484, "2075": 0.030771657824516296, "2109": 0.10555581003427505, "2129": 0.18573370575904846, "21... | 6137330 | OBJECTIVES The objective of this article is to update previous evidence-based recommendations for evaluation and management of individuals with solid pulmonary nodules and to generate new recommendations for those with nonsolid nodules. METHODS We updated prior literature reviews, synthesized evidence, and formulated r... | Evaluation of individuals with pulmonary nodules: when is it lung cancer? Diagnosis and management of lung cancer, 3rd ed: American College of Chest Physicians evidence-based clinical practice guidelines. |
{"1040": 0.1970241367816925, "1999": 0.02412080205976963, "2007": 0.036437395960092545, "2008": 0.04394211992621422, "2011": 0.19381128251552582, "2019": 0.33115679025650024, "2029": 0.1710275560617447, "2038": 0.0019512200960889459, "2063": 0.25694093108177185, "2064": 0.016465263441205025, "2079": 0.08692999184131622... | 6144337 | Activation of the insect innate immune system is dependent on a limited number of pattern recognition receptors (PRRs) capable of interacting with pathogen-associated molecular pattern. Here we report a novel role of an alternatively spliced hypervariable immunoglobulin domain-encoding gene, Dscam, in generating a broa... | AgDscam, a Hypervariable Immunoglobulin Domain-Containing Receptor of the Anopheles gambiae Innate Immune System |
{"1015": 0.6128603219985962, "1019": 0.4624064862728119, "1038": 0.6296497583389282, "1043": 0.35403475165367126, "1048": 0.5635144114494324, "1155": 0.42096930742263794, "1156": 0.5762182474136353, "2011": 0.056018441915512085, "2028": 0.14179791510105133, "2035": 0.3283478021621704, "2044": 0.1734936386346817, "2066"... | 6144969 | Virally induced inflammatory responses, beta cell destruction and release of beta cell autoantigens may lead to autoimmune reactions culminating in type 1 diabetes. Therefore, viral capability to induce beta cell death and the nature of virus-induced immune responses are among key determinants of diabetogenic viruses. ... | Enterovirus-induced gene expression profile is critical for human pancreatic islet destruction |
{"1009": 0.29981520771980286, "1011": 0.2018241584300995, "1015": 0.672426164150238, "1016": 0.29109421372413635, "1048": 0.20102575421333313, "1055": 0.07068414986133575, "1059": 0.5478278398513794, "1996": 0.014542185701429844, "1998": 0.08782484382390976, "2003": 1.0775588750839233, "2004": 0.17267228662967682, "200... | 6148876 | RATIONALE Islet1 (Isl1) has been proposed as a marker of cardiac progenitor cells derived from the second heart field and is utilized to identify and purify cardiac progenitors from murine and human specimens for ex vivo expansion. The use of Isl1 as a specific second heart field marker is dependent on its exclusion fr... | Islet1 derivatives in the heart are of both neural crest and second heart field origin. |
{"1044": 0.29255300760269165, "1999": 0.25694093108177185, "2003": 0.0019512200960889459, "2010": 0.5272908806800842, "2022": 0.04207121208310127, "2038": 0.04767346754670143, "2042": 0.21372433006763458, "2044": 0.8649974465370178, "2051": 0.13157635927200317, "2064": 0.31845372915267944, "2067": 0.5805994272232056, "... | 6153754 | In patients with spinal cord injury, the primary or mechanical trauma seldom causes total transection, even though the functional loss may be complete. In addition, biochemical and pathological changes in the cord may worsen after injury. To explain these phenomena, the concept of the secondary injury has evolved for w... | Review of the secondary injury theory of acute spinal cord trauma with emphasis on vascular mechanisms. |
{"1011": 0.018384648486971855, "1996": 0.021256839856505394, "1998": 0.1970241367816925, "1999": 0.2990913391113281, "2007": 0.25845035910606384, "2008": 0.021256839856505394, "2011": 0.03360854089260101, "2012": 0.29400965571403503, "2015": 0.0038986403960734606, "2029": 0.259204238653183, "2043": 0.03360854089260101,... | 6157371 | Actin and its key regulatory component, cofilin, are found together in large rod-shaped assemblies in neurons subjected to energy stress. Such inclusions are also enriched in Alzheimer's disease brain, and appear in transgenic models of neurodegeneration. Neuronal insults, such as energy loss and/or oxidative stress, r... | Chronophin mediates an ATP-sensing mechanism for cofilin dephosphorylation and neuronal cofilin-actin rod formation. |
{"1016": 0.06429435312747955, "1043": 0.6207655072212219, "1044": 0.4286321699619293, "2003": 0.12728634476661682, "2004": 0.13755162060260773, "2005": 0.24018502235412598, "2007": 0.06154331564903259, "2011": 0.21922965347766876, "2019": 0.3519764244556427, "2024": 0.17267228662967682, "2043": 0.10379679501056671, "20... | 6157837 | Angiotensin converting enzyme (ACE) inhibitors are now one of the most frequently used classes of antihypertensive drugs. Beyond their utility in the management of hypertension, their use has been extended to the long-term management of patients with congestive heart failure (CHF), as well as diabetic and nondiabetic n... | Renal considerations in angiotensin converting enzyme inhibitor therapy: a statement for healthcare professionals from the Council on the Kidney in Cardiovascular Disease and the Council for High Blood Pressure Research of the American Heart Association. |
{"1011": 0.013579257763922215, "1014": 0.3339579105377197, "1026": 0.11168810725212097, "1040": 0.8161250352859497, "1052": 0.5116065740585327, "1999": 0.4974553883075714, "2006": 0.015504186972975731, "2007": 0.3662964701652527, "2011": 0.07068414986133575, "2012": 0.3810817003250122, "2026": 0.7482418417930603, "2029... | 6158879 | BACKGROUND Patients with diabetes mellitus (DM) are at high risk for recurrent cardiovascular events after acute coronary syndromes, in part because of increased platelet reactivity. The Trial to Assess Improvement in Therapeutic Outcomes by Optimizing Platelet Inhibition With Prasugrel-Thrombolysis in Myocardial Infar... | Greater clinical benefit of more intensive oral antiplatelet therapy with prasugrel in patients with diabetes mellitus in the trial to assess improvement in therapeutic outcomes by optimizing platelet inhibition with prasugrel-Thrombolysis in Myocardial Infarction 38. |
{"1006": 0.16110190749168396, "1009": 0.5882205963134766, "1016": 0.09761575609445572, "1048": 0.34922540187835693, "1056": 0.8247235417366028, "1996": 0.2830325961112976, "2000": 0.11951763927936554, "2007": 0.1229778528213501, "2011": 0.36290550231933594, "2012": 0.08244366943836212, "2015": 0.08064348995685577, "202... | 6163801 | Cytolytic granules mediate killing of virus-infected cells by cytotoxic T lymphocytes. We show here that the granules can take long or short paths to the secretory domain. Both paths utilized the same intracellular molecular events, which have different spatial and temporal arrangements and are regulated by the kinetic... | Kinetics of early T cell receptor signaling regulate the pathway of lytic granule delivery to the secretory domain. |
{"1011": 0.08871890604496002, "1015": 0.5517725944519043, "1016": 0.33605360984802246, "1050": 0.18411032855510712, "1056": 0.037378571927547455, "2011": 0.40741631388664246, "2012": 0.33115679025650024, "2028": 0.26296505331993103, "2029": 0.28082266449928284, "2048": 0.08244366943836212, "2058": 0.29109421372413635, ... | 6171953 | Inflammation accompanies obesity and its comorbidities-type 2 diabetes, non-alcoholic fatty liver disease and atherosclerosis, among others-and may contribute to their pathogenesis. Yet the cellular machinery that links nutrient sensing to inflammation remains incompletely characterized. The protein deacetylase sirtuin... | Sirtuin-1 is a nutrient-dependent modulator of inflammation |
{"1015": 0.2741633653640747, "1016": 0.4318077862262726, "1017": 0.5450005531311035, "1041": 0.1808556467294693, "1046": 0.011650617234408855, "1051": 0.1994270235300064, "1997": 0.11168810725212097, "2000": 0.12986256182193756, "2001": 0.007782140281051397, "2005": 0.08244366943836212, "2013": 0.4752389192581177, "201... | 6173523 | IMPORTANCE Identification of the bacterium responsible for an outbreak can aid in disease management. However, traditional culture-based diagnosis can be difficult, particularly if no specific diagnostic test is available for an outbreak strain. OBJECTIVE To explore the potential of metagenomics, which is the direct se... | A culture-independent sequence-based metagenomics approach to the investigation of an outbreak of Shiga-toxigenic Escherichia coli O104:H4. |
{"1011": 0.11256109178066254, "1014": 0.129004567861557, "1015": 0.18167030811309814, "1016": 0.7818660736083984, "1019": 0.00875066313892603, "1038": 0.4932899475097656, "1039": 0.6744182109832764, "1041": 0.7482418417930603, "1052": 0.06703783571720123, "1058": 0.010684899985790253, "2001": 0.08244366943836212, "2011... | 6176498 | CONTEXT Endothelial dysfunction occurs in diagnosed type 2 diabetes mellitus but may also precede development of diabetes. OBJECTIVE To determine whether elevated plasma levels of biomarkers reflecting endothelial dysfunction (E-selectin; intercellular adhesion molecule 1 [ICAM-1]; and vascular cell adhesion molecule 1... | Biomarkers of endothelial dysfunction and risk of type 2 diabetes mellitus. |
{"1022": 0.5707147121429443, "1037": 0.9225212931632996, "1038": 0.24018502235412598, "1041": 0.02792670577764511, "1043": 0.1221139207482338, "1045": 0.21293537318706512, "1050": 0.05417001247406006, "1051": 0.450652539730072, "2007": 0.1384023278951645, "2011": 0.347847044467926, "2012": 0.755608320236206, "2013": 0.... | 6182947 | BACKGROUND Influenza A virus (IAV) infection primarily targets respiratory epithelial cells and produces clinical outcomes ranging from mild upper respiratory infection to severe pneumonia. Recent studies have shown the importance of lung antioxidant defense systems against injury by IAV. Nuclear factor-erythroid 2 rel... | Nrf2 protects human alveolar epithelial cells against injury induced by influenza A virus |
{"1996": 0.15777134895324707, "1997": 0.09495500475168228, "1998": 0.04487626627087593, "2012": 0.10291612148284912, "2015": 0.016465263441205025, "2024": 0.14179791510105133, "2054": 0.3141832649707794, "2064": 0.036437395960092545, "2070": 0.045809537172317505, "2077": 0.022212404757738113, "2079": 0.1970241367816925... | 6190603 | Cell membranes are fascinating supramolecular aggregates that not only form a barrier between compartments but also harbor many chemical reactions essential to the existence and functioning of a cell. Here, it is proposed to review the molecular dynamics and mosaic organization of the plasma membrane, which are thought... | Dynamics in the plasma membrane: how to combine fluidity and order. |
{"1011": 0.03925827145576477, "1014": 0.10379679501056671, "1040": 0.5438674688339233, "1041": 0.05046287178993225, "1050": 0.33953672647476196, "1052": 0.42990362644195557, "1998": 0.11168810725212097, "2005": 0.2470736801624298, "2015": 0.19622190296649933, "2020": 0.012615402229130268, "2051": 0.1212492436170578, "2... | 6191684 | CONTEXT Chronic tension-type headaches are characterized by near-daily headaches and often are difficult to manage in primary practice. Behavioral and pharmacological therapies each appear modestly effective, but data are lacking on their separate and combined effects. OBJECTIVE To evaluate the clinical efficacy of beh... | Management of chronic tension-type headache with tricyclic antidepressant medication, stress management therapy, and their combination: a randomized controlled trial. |
{"1011": 0.1619328260421753, "2000": 0.04487626627087593, "2007": 0.1221139207482338, "2022": 0.02792670577764511, "2047": 0.36086538434028625, "2057": 0.016465263441205025, "2058": 0.19862671196460724, "2060": 0.1221139207482338, "2061": 0.2409527748823166, "2062": 0.25845035910606384, "2064": 0.2852376699447632, "206... | 6202834 | The understanding that gene trees are often in discord with each other and with the species trees that contain them has led researchers to methods that incorporate the inherent stochasticity of genetic processes in the phylogenetic estimation procedure. Recently developed methods for species-tree estimation that not on... | Maximum likelihood estimates of species trees: how accuracy of phylogenetic inference depends upon the divergence history and sampling design. |
{"1998": 0.10993985831737518, "2058": 0.6011518239974976, "2060": 0.2969166338443756, "2062": 0.014542185701429844, "2088": 0.6430866718292236, "2090": 0.03266380727291107, "2095": 0.3723714053630829, "2109": 0.1011524572968483, "2111": 0.31489628553390503, "2116": 0.10993985831737518, "2172": 0.3304552733898163, "2224... | 6207111 | OBJECTIVES We estimated the relationship between soft drink consumption and obesity and diabetes worldwide. METHODS We used multivariate linear regression to estimate the association between soft drink consumption and overweight, obesity, and diabetes prevalence in 75 countries, controlling for other foods (cereals, me... | Relationship of soft drink consumption to global overweight, obesity, and diabetes: a cross-national analysis of 75 countries. |
{"1011": 0.35745587944984436, "1020": 0.6970458030700684, "1049": 0.861702561378479, "1050": 0.8433839678764343, "1997": 0.1913948506116867, "1999": 0.06246116757392883, "2005": 0.06795065850019455, "2008": 0.07793712615966797, "2011": 0.3005385100841522, "2013": 0.11256109178066254, "2015": 0.25088030099868774, "2029"... | 6209599 | Extensive pre-mRNA back-splicing generates numerous circular RNAs (circRNAs) in human transcriptome. However, the biological functions of these circRNAs remain largely unclear. Here we report that N6-methyladenosine (m6A), the most abundant base modification of RNA, promotes efficient initiation of protein translation ... | Extensive translation of circular RNAs driven by N6-methyladenosine |
{"1011": 0.2837681770324707, "1014": 0.15023678541183472, "1039": 0.12384103983640671, "1048": 0.495672345161438, "1051": 0.08513788133859634, "1052": 0.2800849378108978, "1058": 1.020087480545044, "1999": 0.09672962874174118, "2007": 0.26296505331993103, "2011": 0.05694137513637543, "2029": 0.2576959431171417, "2033":... | 6212802 | BACKGROUND Saphenous vein graft (VG) failure occurs more frequently compared with arterial grafts, and graft thrombosis represents the main cause of early occlusion. Because CD40-CD40L pathway CD40 represents a culprit link between local inflammation and coagulation cascade, we investigate the role of CD40 and its solu... | Simvastatin reduces CD40 expression in an experimental model of early arterialization of saphenous vein graft. |
{"1011": 0.0354953333735466, "2003": 0.055094651877880096, "2005": 0.2786078155040741, "2007": 0.1401015669107437, "2013": 0.4400174915790558, "2015": 0.029824240133166313, "2037": 0.09406650811433792, "2064": 0.306306391954422, "2079": 0.32129061222076416, "2081": 0.09938567131757736, "2091": 0.30989447236061096, "210... | 6219790 | Cell-derived nanoparticles have been garnering increased attention due to their ability to mimic many of the natural properties displayed by their source cells. This top-down engineering approach can be applied toward the development of novel therapeutic strategies owing to the unique interactions enabled through the r... | Cancer Cell Membrane-Coated Nanoparticles for Anticancer Vaccination and Drug Delivery |
{"1021": 0.3283478021621704, "1042": 0.823009729385376, "2007": 0.11256109178066254, "2011": 0.23710809648036957, "2012": 0.8195732831954956, "2020": 0.04487626627087593, "2029": 0.23324857652187347, "2057": 0.38441169261932373, "2058": 0.04674193635582924, "2076": 0.052318159490823746, "2106": 0.10818854719400406, "21... | 6227220 | Despite growing interest and a recent surge in papers, the role of autophagy in glucose and lipid metabolism is unclear. We produced mice with skeletal muscle–specific deletion of Atg7 (encoding autophagy-related 7). Unexpectedly, these mice showed decreased fat mass and were protected from diet-induced obesity and ins... | Autophagy deficiency leads to protection from obesity and insulin resistance by inducing Fgf21 as a mitokine |
{"1013": 0.08961215615272522, "1014": 0.27786844968795776, "1054": 0.10906458646059036, "2000": 0.22704219818115234, "2003": 0.009718249551951885, "2006": 0.08244366943836212, "2007": 0.37371641397476196, "2012": 0.8691008687019348, "2039": 0.14433705806732178, "2043": 0.09850110858678818, "2050": 0.17759032547473907, ... | 6250701 | BACKGROUND Acute renal failure is a common complication of severe malaria in adults, and without renal replacement therapy (RRT), it carries a poor prognosis. Even when RRT is available, delaying its initiation may increase mortality. Earlier identification of patients who will need RRT may improve outcomes. METHOD Pro... | Laboratory prediction of the requirement for renal replacement in acute falciparum malaria |
{"1011": 0.2516399025917053, "1017": 0.026976587250828743, "1039": 0.5080875158309937, "1043": 0.20580662786960602, "1052": 0.5784112811088562, "1059": 0.16690383851528168, "2004": 0.0174254160374403, "2005": 0.30558720231056213, "2006": 0.24631060659885406, "2007": 0.16690383851528168, "2011": 0.03266380727291107, "20... | 6251620 | Antineutrophil cytoplasmic antibodies (ANCA) are a sensitive and specific marker for ANCA-associated systemic vasculitis. Using indirect immunofluorescence on ethanol-fixed neutrophils, two major fluoroscopic patterns can be recognised: a diffuse cytoplasmic staining (C-ANCA), and a perinuclear/nuclear staining (P-ANCA... | Antineutrophil cytoplasmic antibodies (ANCA). |
{"1011": 0.09228714555501938, "1016": 0.42990362644195557, "1039": 0.4873090982437134, "1042": 0.3777405619621277, "1050": 0.45251765847206116, "1054": 0.16442140936851501, "2008": 0.02792670577764511, "2011": 0.42799583077430725, "2029": 0.2145126610994339, "2034": 0.015504186972975731, "2043": 0.02792670577764511, "2... | 6259170 | Nuclear factor erythroid-derived 2-related factor 2 (Nrf2) was originally identified as a positive regulator of drug detoxifying enzyme gene expression during exposure to environmental electrophiles. Currently, Nrf2 is known to regulate the expression of hundreds of cytoprotective genes to counteract endogenously or ex... | Emerging functional cross-talk between the Keap1-Nrf2 system and mitochondria |
{"1052": 0.0019512200960889459, "1996": 0.07159364968538284, "2008": 0.0354953333735466, "2011": 0.0019512200960889459, "2015": 0.18004031479358673, "2024": 0.02316705882549286, "2029": 0.13670019805431366, "2075": 0.29255300760269165, "2076": 0.045809537172317505, "2079": 0.23556606471538544, "2107": 0.152754619717597... | 6264468 | Establishment, maintenance, and exit from pluripotency require precise coordination of a cell's molecular machinery. Substantial headway has been made in deciphering many aspects of this elaborate system, particularly with respect to epigenetics, transcription, and noncoding RNAs. Less attention has been paid to posttr... | Regulation of pluripotency by RNA binding proteins. |
{"1011": 0.21293537318706512, "1040": 0.684319257736206, "1041": 0.4145384132862091, "1048": 0.22704219818115234, "1057": 0.823009729385376, "1060": 0.49626702070236206, "1158": 0.037378571927547455, "1996": 0.17020416259765625, "1998": 0.1970241367816925, "1999": 0.04207121208310127, "2003": 0.006812678650021553, "200... | 6268106 | The receptor Notch and its ligands of the Delta/Serrate/LAG2 (DSL) family are the central components in the Notch pathway, a fundamental cell signaling system that regulates pattern formation during animal development. Delta is directly ubiquitinated by Drosophila and Xenopus Neuralized, and by zebrafish Mind bomb, two... | The ubiquitin ligase Drosophila Mind bomb promotes Notch signaling by regulating the localization and activity of Serrate and Delta. |
{"1007": 0.22859740257263184, "1009": 0.5528968572616577, "1011": 0.2800849378108978, "1013": 0.11343330889940262, "1015": 0.47827014327049255, "1022": 0.5573811531066895, "1045": 0.6548244953155518, "1056": 0.7191727757453918, "1999": 0.25088030099868774, "2005": 0.05786345899105072, "2006": 0.040196798741817474, "200... | 6270720 | RATIONALE The myeloid differentiation factor (MyD)88/interleukin (IL)-1 axis activates self-antigen-presenting cells and promotes autoreactive CD4(+) T-cell expansion in experimental autoimmune myocarditis, a mouse model of inflammatory heart disease. OBJECTIVE The aim of this study was to determine the role of MyD88 a... | Myeloid differentiation factor-88/interleukin-1 signaling controls cardiac fibrosis and heart failure progression in inflammatory dilated cardiomyopathy. |
{"1036": 0.3870677351951599, "1045": 0.29981520771980286, "1996": 0.11691460013389587, "2003": 0.19220098853111267, "2005": 0.09495500475168228, "2008": 0.026025565341114998, "2011": 0.2983669638633728, "2029": 0.043007105588912964, "2054": 0.02792670577764511, "2071": 0.1685553640127182, "2076": 0.1718502640724182, "2... | 6277638 | The target of rapamycin (TOR) pathway is a major nutrient-sensing pathway that, when genetically downregulated, increases life span in evolutionarily diverse organisms including mammals. The central component of this pathway, TOR kinase, is the target of the inhibitory drug rapamycin, a highly specific and well-describ... | Mechanisms of Life Span Extension by Rapamycin in the Fruit Fly Drosophila melanogaster |
{"1011": 0.06337817758321762, "1018": 0.06520967930555344, "1038": 0.6960725784301758, "1042": 0.906871497631073, "1051": 0.13499516248703003, "1056": 0.6155022978782654, "1156": 0.5767669677734375, "2000": 0.012615402229130268, "2007": 0.09850110858678818, "2011": 0.3262358605861664, "2029": 0.19622190296649933, "2033... | 6280907 | Mesenchymal stem cells can give rise to several cell types, but varying results depending on isolation methods and tissue source have led to controversies about their usefulness in clinical medicine. Here we show that vascular endothelial cells can transform into multipotent stem-like cells by an activin-like kinase-2 ... | Conversion of vascular endothelial cells into multipotent stem-like cells |
{"1011": 0.45623743534088135, "1040": 0.6759096384048462, "1042": 0.27342069149017334, "1049": 0.29255300760269165, "2008": 0.007782140281051397, "2011": 0.2561853528022766, "2012": 0.1064341589808464, "2015": 0.08064348995685577, "2029": 0.2607102394104004, "2038": 0.10731173306703568, "2043": 0.27712854743003845, "20... | 6285534 | The evolutionarily conserved miR-302 family of microRNAs is expressed during early mammalian embryonic development. Here, we report that deletion of miR-302a-d in mice results in a fully penetrant late embryonic lethal phenotype. Knockout embryos have an anterior neural tube closure defect associated with a thickened n... | miR-302 Is Required for Timing of Neural Differentiation, Neural Tube Closure, and Embryonic Viability |
{"1011": 0.27342069149017334, "1014": 0.13243216276168823, "1015": 0.10731173306703568, "1020": 0.18004031479358673, "1023": 0.2749055027961731, "1026": 0.07793712615966797, "1038": 0.6461620330810547, "1049": 0.3077431619167328, "1052": 0.42096930742263794, "1058": 0.1718502640724182, "2007": 0.2223619967699051, "2028... | 6290112 | Common multi-allelic copy number variants (CNVs) appear enriched for phenotypic associations compared to their biallelic counterparts. Here we investigated the influence of gene dosage effects on adiposity through a CNV association study of gene expression levels in adipose tissue. We identified significant association... | Low copy number of the salivary amylase gene predisposes to obesity |
{"1998": 0.5778634548187256, "2007": 0.10731173306703568, "2012": 0.13670019805431366, "2013": 0.1332872211933136, "2037": 0.37640097737312317, "2044": 0.08244366943836212, "2054": 0.10467668622732162, "2055": 0.3070250153541565, "2058": 0.1212492436170578, "2062": 0.18492233753204346, "2070": 0.34300774335861206, "210... | 6296189 | Many people are exposed to loss or potentially traumatic events at some point in their lives, and yet they continue to have positive emotional experiences and show only minor and transient disruptions in their ability to function. Unfortunately, because much of psychology's knowledge about how adults cope with loss or ... | Loss, trauma, and human resilience: have we underestimated the human capacity to thrive after extremely aversive events? |
{"1011": 0.04953393340110779, "1015": 0.0913962796330452, "1016": 0.11951763927936554, "1017": 0.21293537318706512, "1047": 0.1685553640127182, "2005": 0.1477125883102417, "2012": 0.045809537172317505, "2025": 0.13755162060260773, "2029": 0.11343330889940262, "2044": 0.42608439922332764, "2048": 0.0354953333735466, "20... | 6308416 | Coordinated cell movements in epithelial layers are essential for proper tissue morphogenesis and homeostasis, but our understanding of the mechanisms that coordinate the behavior of multiple cells in these processes is far from complete. Recent experiments with Madin-Darby canine kidney epithelial monolayers revealed ... | Role of boundary conditions in an experimental model of epithelial wound healing. |
{"1020": 0.052318159490823746, "2005": 0.10731173306703568, "2014": 0.006812678650021553, "2039": 0.11081436276435852, "2043": 0.1332872211933136, "2044": 0.24631060659885406, "2062": 0.29473719000816345, "2076": 0.3381449282169342, "2086": 0.4950772523880005, "2087": 0.02887592278420925, "2089": 0.3127557039260864, "2... | 6309659 | CONTEXT Exogenous estrogen use may lower risk of dementia in postmenopausal women. A relationship between long-term exposure to endogenous estrogens and incident dementia has been hypothesized but not studied. OBJECTIVE To determine whether a longer reproductive period, as an indicator of longer exposure to endogenous ... | Reproductive period and risk of dementia in postmenopausal women. |
{"1015": 0.603290855884552, "1043": 1.0973093509674072, "1044": 0.08603433519601822, "1045": 0.8517522215843201, "2028": 0.29473719000816345, "2029": 0.1930064558982849, "2066": 0.5393219590187073, "2075": 0.6456501483917236, "2079": 0.15023678541183472, "2086": 0.011650617234408855, "2094": 0.678390383720398, "2146": ... | 6313547 | Present knowledge on the effects of growth hormone (GH)/insulin-like growth hormone (IGF)1 deficiency on ageing and lifespan are reviewed. Evidence is presented that isolated GH deficiency (IGHD), multiple pituitary hormone deficiencies (MPHD) including GH, as well as primary IGE1 deficiency (GH resistance, Laron syndr... | Effects of growth hormone and insulin-like growth factor 1 deficiency on ageing and longevity. |
{"1011": 0.09938567131757736, "1015": 0.23710809648036957, "1040": 0.151916041970253, "1043": 0.4938860833644867, "1044": 0.004870930220931768, "1047": 1.0999135971069336, "2002": 0.6139179468154907, "2004": 0.2223619967699051, "2005": 0.1994270235300064, "2007": 0.19782574474811554, "2011": 0.09050461649894714, "2013"... | 6315132 | We describe a case of severe neonatal anemia with kernicterus caused by compound heterozygosity for null mutations in KLF1, each inherited from asymptomatic parents. One of the mutations is novel. This is the first described case of a KLF1-null human. The phenotype of severe nonspherocytic hemolytic anemia, jaundice, h... | KLF1-null neonates display hydrops fetalis and a deranged erythroid transcriptome. |
{"1011": 0.2830325961112976, "1016": 0.20580662786960602, "1044": 0.5033760666847229, "1045": 0.5086748600006104, "1054": 0.6286086440086365, "1997": 0.2976420819759369, "2000": 0.10291612148284912, "2006": 0.02792670577764511, "2064": 0.1602703034877777, "2089": 0.055094651877880096, "2090": 0.3070250153541565, "2093"... | 6319826 | The extent of heterogeneity in a meta-analysis partly determines the difficulty in drawing overall conclusions. This extent may be measured by estimating a between-study variance, but interpretation is then specific to a particular treatment effect metric. A test for the existence of heterogeneity exists, but depends o... | Quantifying heterogeneity in a meta-analysis. |
{"1043": 1.1695996522903442, "2005": 0.10291612148284912, "2011": 0.14349138736724854, "2034": 0.2247048318386078, "2048": 0.18411032855510712, "2050": 0.820433497428894, "2089": 0.09495500475168228, "2094": 0.09406650811433792, "2109": 0.026976587250828743, "2117": 0.8383291959762573, "2128": 0.6522845029830933, "2141... | 6323196 | Interest in the neurocognitive and psychosocial outcomes in children who are born small for gestational age (SGA) has increased since the recent approval of growth hormone (GH) therapy in this indication. The objective of GH treatment in SGA children is to provide a symptomatic treatment for growth retardation. From a ... | Neurocognitive Development in Children Experiencing Intrauterine Growth Retardation and Born Small for Gestational Age: Pathological, Constitutional and Therapeutic Pathways |
{"1011": 0.3656192123889923, "1038": 0.3601844012737274, "1043": 0.6573580503463745, "1059": 0.5489565134048462, "1156": 0.469759464263916, "2011": 0.129004567861557, "2029": 0.1358480453491211, "2078": 0.18329764902591705, "2080": 0.777387797832489, "2099": 0.7163142561912537, "2179": 0.09761575609445572, "2188": 0.21... | 6325527 | Although blood–brain barrier (BBB) compromise is central to the etiology of diverse central nervous system (CNS) disorders, endothelial receptor proteins that control BBB function are poorly defined. The endothelial G-protein-coupled receptor (GPCR) Gpr124 has been reported to be required for normal forebrain angiogene... | Gpr124 is essential for blood–brain barrier integrity in central nervous system disease |
{"1043": 0.7737906575202942, "1045": 0.7445381283760071, "1054": 0.28082266449928284, "1997": 0.011650617234408855, "1999": 0.3127557039260864, "2002": 0.8641747236251831, "2004": 0.255429208278656, "2005": 0.12986256182193756, "2011": 0.2531573474407196, "2015": 0.021256839856505394, "2029": 0.012615402229130268, "203... | 6327940 | Amino acids modulate the secretion of both insulin and glucagon; the composition of dietary protein therefore has the potential to influence the balance of glucagon and insulin activity. Soy protein, as well as many other vegan proteins, are higher in non-essential amino acids than most animal-derived food proteins, an... | Vegan proteins may reduce risk of cancer, obesity, and cardiovascular disease by promoting increased glucagon activity. |
{"1011": 0.27712854743003845, "1015": 0.14518201351165771, "1016": 0.7500885725021362, "1047": 0.0038986403960734606, "1051": 0.44566190242767334, "1996": 0.03266380727291107, "1999": 0.05417001247406006, "2004": 0.4574742913246155, "2006": 0.2976420819759369, "2007": 0.03266380727291107, "2011": 0.23324857652187347, "... | 6333347 | An emerging family of kinases related to the Drosophila Aurora and budding yeast Ipl1 proteins has been implicated in chromosome segregation and mitotic spindle formation in a number of organisms. Unlike other Aurora/Ipl1-related kinases, the Caenorhabditis elegans orthologue, AIR-2, is associated with meiotic and mito... | AIR-2: An Aurora/Ipl1-related Protein Kinase Associated with Chromosomes and Midbody Microtubules Is Required for Polar Body Extrusion and Cytokinesis in Caenorhabditis elegans Embryos |
{"1011": 0.04113444685935974, "1014": 0.1221139207482338, "1042": 1.2307592630386353, "1048": 0.026025565341114998, "2003": 0.11865071207284927, "2034": 0.22157983481884003, "2063": 0.37707099318504333, "2076": 0.26146242022514343, "2078": 1.2267581224441528, "2086": 0.24171993136405945, "2090": 0.20977331697940826, "2... | 6334188 | BACKGROUND Chemotherapy-induced febrile neutropenia (FN) is a clinically important complication that affects patient outcome by delaying chemotherapy doses or reducing dose intensity. Risk of FN depends on chemotherapy- and patient-level factors. We sought to determine the effects of chronic comorbidities on risk of FN... | History of chronic comorbidity and risk of chemotherapy-induced febrile neutropenia in cancer patients not receiving G-CSF prophylaxis. |
{"1011": 0.1677299439907074, "1015": 0.02887592278420925, "1017": 0.15526613593101501, "1038": 0.026976587250828743, "1040": 0.13071982562541962, "1041": 0.535327672958374, "1043": 1.0271050930023193, "1050": 0.37907835841178894, "1052": 0.0913962796330452, "1061": 0.2711893916130066, "2002": 0.5220900774002075, "2003"... | 6363093 | BACKGROUND Glioblastoma multiforme (GBM) is an umbrella designation that includes a heterogeneous group of primary brain tumors. Several classification strategies of GBM have been reported, some by clinical course and others by resemblance to cell types either in the adult or during development. From a practical and th... | Glioblastoma Subclasses Can Be Defined by Activity among Signal Transduction Pathways and Associated Genomic Alterations |
{"1058": 1.3525274991989136, "1996": 0.47158926725387573, "2003": 0.026025565341114998, "2008": 0.02887592278420925, "2011": 0.0752234235405922, "2029": 0.08513788133859634, "2037": 0.06337817758321762, "2053": 0.319873183965683, "2076": 0.0317181795835495, "2079": 0.3750596046447754, "2080": 0.08692999184131622, "2083... | 6368017 | The mouse vomeronasal organ (VNO) is thought to mediate social behaviors and neuroendocrine changes elicited by pheromonal cues. The molecular mechanisms underlying the sensory response to pheromones and the behavioral repertoire induced through the VNO are not fully characterized. Using the tools of mouse genetics and... | Loss of sex discrimination and male-male aggression in mice deficient for TRP2. |
{"1039": 0.8450632095336914, "1040": 0.5838727951049805, "1042": 0.02887592278420925, "1999": 0.13071982562541962, "2004": 0.05694137513637543, "2005": 0.05970508232712746, "2029": 0.03831886500120163, "2038": 0.016465263441205025, "2044": 0.22001366317272186, "2061": 0.5751199722290039, "2062": 0.06246116757392883, "2... | 6372244 | Antibiotics can have significant and long-lasting effects on the gastrointestinal tract microbiota, reducing colonization resistance against pathogens including Clostridium difficile. Here we show that antibiotic treatment induces substantial changes in the gut microbial community and in the metabolome of mice suscepti... | Antibiotic-induced shifts in the mouse gut microbiome and metabolome increase susceptibility to Clostridium difficile infection |
{"1011": 0.43812891840934753, "1015": 0.6286086440086365, "1018": 0.28890204429626465, "1020": 0.0752234235405922, "1038": 0.7907629609107971, "1039": 0.8323994874954224, "1041": 0.12038381397724152, "1043": 0.2763880789279938, "1048": 0.053244512528181076, "1060": 0.2749055027961731, "2005": 0.11778303235769272, "2007... | 6374918 | The CXCR4-SDF-1 axis plays a central role in the trafficking and retention of normal and malignant stem cells in the bone marrow (BM) microenvironment. Here, we used a mouse model of acute promyelocytic leukemia (APL) and a small molecule competitive antagonist of CXCR4, AMD3100, to examine the interaction of mouse APL... | Chemosensitization of acute myeloid leukemia (AML) following mobilization by the CXCR4 antagonist AMD3100. |
{"1011": 0.5551415085792542, "1017": 0.19862671196460724, "1018": 0.46117570996284485, "1040": 0.18329764902591705, "1043": 0.9886114001274109, "1054": 0.8039615154266357, "1997": 0.1693800985813141, "2002": 0.6270449161529541, "2004": 0.6353566646575928, "2005": 0.14686977863311768, "2007": 0.27564704418182373, "2010"... | 6386930 | Four-stranded nucleic acid structures called G-quadruplexes have been associated with important cellular processes, which should require G-quadruplex-protein interaction. However, the structural basis for specific G-quadruplex recognition by proteins has not been understood. The DEAH (Asp-Glu-Ala-His) box RNA helicase ... | Insights into G-quadruplex specific recognition by the DEAH-box helicase RHAU: Solution structure of a peptide-quadruplex complex. |
{"1042": 0.07793712615966797, "1053": 0.04487626627087593, "1056": 0.09672962874174118, "2045": 0.25694093108177185, "2053": 0.09495500475168228, "2057": 0.6769026517868042, "2066": 0.9131608605384827, "2086": 0.10026945173740387, "2089": 0.176772341132164, "2090": 0.4518963396549225, "2152": 0.22937409579753876, "2214... | 6387956 | BACKGROUND Non-clinical psychotic symptoms appear common in children, but it is possible that a proportion of reported symptoms result from misinterpretation. There is a well-established association between pre-morbid low IQ score and schizophrenia. Psychosis-like symptoms in children may also be a risk factor for psyc... | IQ and non-clinical psychotic symptoms in 12-year-olds: results from the ALSPAC birth cohort |
{"1011": 0.5990082025527954, "1015": 1.0437490940093994, "1039": 0.7951818704605103, "1041": 0.9635916948318481, "1045": 0.3554046154022217, "1057": 0.19220098853111267, "1999": 0.10026945173740387, "2003": 0.18167030811309814, "2004": 0.08961215615272522, "2011": 0.41001203656196594, "2013": 0.10026945173740387, "2015... | 6397191 | Endothelin-1 (ET-1) is the predominant endothelin isopeptide generated by the vascular wall and therefore appears to be the most important peptide involved in regulation of cardiovascular events. Many pathologic conditions are associated with elevations of ET-1 in the blood vessel wall. Because these conditions are oft... | Endothelin-1 is induced by cytokines in human vascular smooth muscle cells: evidence for intracellular endothelin-converting enzyme. |
{"1011": 0.043007105588912964, "1017": 0.38174858689308167, "1018": 0.37371641397476196, "1019": 0.15023678541183472, "1039": 0.19782574474811554, "1997": 0.07431721687316895, "1999": 0.1685553640127182, "2006": 0.020300358533859253, "2008": 0.18654440343379974, "2024": 0.020300358533859253, "2029": 0.4818955361843109,... | 6401675 | Detection of new genomic control elements is critical in understanding transcriptional regulatory networks in their entirety. We studied the genome-wide binding locations of three key regulatory proteins (POU5F1, also known as OCT4; NANOG; and CTCF) in human and mouse embryonic stem cells. In contrast to CTCF, we found... | Transposable elements have rewired the core regulatory network of human embryonic stem cells |
{"1007": 0.3757305145263672, "1009": 0.16276304423809052, "1011": 0.1930064558982849, "1049": 0.1970241367816925, "1056": 0.43875885009765625, "2003": 0.15359249711036682, "2005": 0.052318159490823746, "2008": 0.1693800985813141, "2011": 0.3930181860923767, "2014": 0.7314660549163818, "2015": 0.43434104323387146, "2024... | 6404801 | Micro (mi)RNAs are small non-coding RNAs that regulate the expression of their targets' messenger RNAs through both translational inhibition and regulation of target RNA stability. Recently, a number of viruses, particularly of the herpesvirus family, have been shown to express their own miRNAs to control both viral an... | Cytomegalovirus microRNAs Facilitate Persistent Virus Infection in Salivary Glands |
{"1015": 0.524982750415802, "1016": 0.08244366943836212, "1998": 0.04207121208310127, "1999": 0.00875066313892603, "2004": 0.8957691192626953, "2005": 0.5010119676589966, "2007": 0.2830325961112976, "2015": 0.20818853378295898, "2028": 0.16690383851528168, "2029": 0.09672962874174118, "2031": 0.05417001247406006, "2060... | 6407356 | Coxibs, including celecoxib, and other nonsteroidal anti-inflammatory drugs (NSAID), including aspirin, are among the most promising cancer chemopreventive agents in development today. This article examines the data on the efficacy of these agents in animal model studies of cancer prevention carried out by the authors.... | Coxibs and other nonsteroidal anti-inflammatory drugs in animal models of cancer chemoprevention. |
{"1019": 0.20977331697940826, "1022": 0.18248429894447327, "1060": 0.3374483287334442, "1999": 0.4400174915790558, "2002": 0.940220832824707, "2003": 0.12470348179340363, "2005": 0.12642613053321838, "2015": 0.3027053773403168, "2024": 0.18978065252304077, "2029": 0.015504186972975731, "2047": 0.3012613356113434, "2050... | 6415816 | The inborn errors of heme biosynthesis, the porphyrias, are 8 genetically distinct metabolic disorders that can be classified as "acute hepatic," "hepatic cutaneous," and "erythropoietic cutaneous" diseases. Recent advances in understanding their pathogenesis and molecular genetic heterogeneity have led to improved dia... | The porphyrias: advances in diagnosis and treatment. |
{"1009": 0.3554046154022217, "1022": 0.3027053773403168, "1039": 0.09317722171545029, "1998": 0.21214580535888672, "1999": 0.4673144817352295, "2003": 0.1718502640724182, "2007": 0.33953672647476196, "2029": 0.1212492436170578, "2089": 0.07884006202220917, "2090": 0.5478278398513794, "2094": 0.7342816591262817, "2099":... | 6417632 | BACKGROUND COPD is an inflammatory disorder characterised by chronic airflow limitation, but the extent to which airway inflammation is related to functional abnormalities is still uncertain. The interaction between inflammatory cells and airway smooth muscle may have a crucial role. METHODS To investigate the microloc... | Neutrophilic infiltration within the airway smooth muscle in patients with COPD. |
{"1014": 0.19782574474811554, "1017": 0.25845035910606384, "1018": 0.11517547070980072, "1019": 0.04207121208310127, "1040": 0.11430477350950241, "1043": 0.7809720039367676, "1051": 0.2231435477733612, "1997": 0.6022219061851501, "1999": 0.014542185701429844, "2004": 0.025073638185858727, "2013": 0.02792670577764511, "... | 6421734 | OBJECTIVE To investigate the experience of users of out of hours general practitioner services in England, UK. DESIGN Population based cross sectional postal questionnaire survey. SETTING General Practice Patient Survey 2012-13. MAIN OUTCOME MEASURES Potential associations between sociodemographic factors (including et... | Characteristics of service users and provider organisations associated with experience of out of hours general practitioner care in England: population based cross sectional postal questionnaire survey. |
{"1011": 0.1221139207482338, "1016": 0.020300358533859253, "1019": 0.3784096837043762, "1020": 0.2659635543823242, "1038": 0.2447827309370041, "1048": 0.8583967685699463, "1050": 0.12384103983640671, "1056": 0.4425300657749176, "2003": 0.31845372915267944, "2013": 0.15860503911972046, "2029": 0.06886265426874161, "2035... | 6421792 | Acute lymphoblastic leukemia (ALL) is an aggressive hematological tumor resulting from the malignant transformation of lymphoid progenitors. Despite intensive chemotherapy, 20% of pediatric patients and over 50% of adult patients with ALL do not achieve a complete remission or relapse after intensified chemotherapy, ma... | Activating mutations in the NT5C2 nucleotidase gene drive chemotherapy resistance in relapsed ALL |
{"1045": 0.2689530849456787, "1057": 1.0960047245025635, "1997": 0.00875066313892603, "2008": 0.10379679501056671, "2011": 0.5607312321662903, "2029": 0.2711893916130066, "2035": 0.0038986403960734606, "2046": 0.15023678541183472, "2049": 0.31489628553390503, "2076": 0.11604541540145874, "2079": 0.11430477350950241, "2... | 6422576 | A growing number of cellular regulatory mechanisms are being linked to protein modification by the polypeptide ubiquitin. These include key transitions in the cell cycle, class I antigen processing, signal transduction pathways, and receptor-mediated endocytosis. In most, but not all, of these examples, ubiquitination ... | Ubiquitin-dependent protein degradation. |
{"1011": 0.15023678541183472, "1015": 0.5092619061470032, "1019": 0.08244366943836212, "1040": 0.4673144817352295, "1041": 0.32058215141296387, "1044": 0.49864232540130615, "1050": 0.7881022095680237, "1053": 0.5517725944519043, "1054": 0.7305257320404053, "1061": 0.5540198087692261, "2000": 0.036437395960092545, "2005... | 6426919 | Recently, mutations in the connection subdomain (CN) and RNase H domain of HIV-1 reverse transcriptase (RT) were observed to exhibit dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors (NRTIs and NNRTIs). To elucidate the mechanism by which CN and RH mutations confer resistance to NNRTIs, w... | A novel molecular mechanism of dual resistance to nucleoside and nonnucleoside reverse transcriptase inhibitors. |
{"1017": 0.1011524572968483, "1996": 0.40871503949165344, "1999": 0.6254787445068359, "2011": 0.006812678650021553, "2029": 0.10291612148284912, "2048": 0.22782009840011597, "2073": 0.19862671196460724, "2079": 0.1485546976327896, "2087": 0.2918238639831543, "2093": 0.49864232540130615, "2112": 0.3423145115375519, "211... | 6431384 | Although the auditory cortex plays a necessary role in sound localization, physiological investigations in the cortex reveal inhomogeneous sampling of auditory space that is difficult to reconcile with localization behavior under the assumption of local spatial coding. Most neurons respond maximally to sounds located f... | Location Coding by Opponent Neural Populations in the Auditory Cortex |
{"1011": 0.14095009863376617, "1015": 0.1485546976327896, "1017": 0.23787821829319, "1018": 0.06703783571720123, "1044": 0.603290855884552, "1060": 0.5584990978240967, "2007": 0.11430477350950241, "2010": 0.8340972661972046, "2012": 0.10026945173740387, "2029": 0.22392450273036957, "2043": 0.04767346754670143, "2046": ... | 6441369 | The interconversion between naive and primed pluripotent states is accompanied by drastic epigenetic rearrangements. However, it is unclear whether intrinsic epigenetic events can drive reprogramming to naive pluripotency or if distinct chromatin states are instead simply a reflection of discrete pluripotent states. He... | MLL1 Inhibition Reprograms Epiblast Stem Cells to Naive Pluripotency. |
{"1011": 0.27342069149017334, "1039": 0.5871354341506958, "1042": 0.18978065252304077, "1047": 0.6980181336402893, "1049": 0.27342069149017334, "1998": 0.03360854089260101, "2007": 0.08871890604496002, "2026": 0.9021284580230713, "2029": 0.2447827309370041, "2039": 0.16359257698059082, "2048": 0.1693800985813141, "2053... | 6446747 | In metazoan organisms, terminal differentiation is generally tightly linked to cell cycle exit, whereas the undifferentiated state of pluripotent stem cells is associated with unlimited self-renewal. Here, we report that combined deficiency for the transcription factors MafB and c-Maf enables extended expansion of matu... | MafB/c-Maf deficiency enables self-renewal of differentiated functional macrophages. |
{"1011": 0.11604541540145874, "1996": 0.11256109178066254, "2003": 0.4177590310573578, "2005": 0.0913962796330452, "2008": 0.06886265426874161, "2011": 0.42096930742263794, "2013": 0.1751343309879303, "2029": 0.1212492436170578, "2039": 0.23556606471538544, "2073": 0.006812678650021553, "2076": 0.0317181795835495, "207... | 6454371 | Macropinocytosis is a regulated form of endocytosis that mediates the non-selective uptake of solute molecules, nutrients and antigens. It is an actin-dependent process initiated from surface membrane ruffles that give rise to large endocytic vacuoles called macropinosomes. Macropinocytosis is important in a range of p... | Macropinocytosis: an endocytic pathway for internalising large gulps. |
{"1011": 0.1913948506116867, "1017": 0.08961215615272522, "1018": 0.1602703034877777, "1019": 0.34508460760116577, "1044": 0.6639154553413391, "1047": 1.0229004621505737, "1048": 0.3588210940361023, "2004": 0.037378571927547455, "2005": 0.1994270235300064, "2007": 0.1873544454574585, "2008": 0.15526613593101501, "2010"... | 6455142 | Although regulation of histone methylation is believed to contribute to embryonic stem cell (ESC) self-renewal, the mechanisms remain obscure. We show here that the histone H3 trimethyl lysine 4 (H3K4me3) demethylase, KDM5B, is a downstream Nanog target and critical for ESC self-renewal. Although KDM5B is believed to f... | KDM5B regulates embryonic stem cell self-renewal and represses cryptic intragenic transcription. |
{"1011": 0.39762192964553833, "1015": 0.3554046154022217, "1045": 0.6793810129165649, "1047": 1.0815403461456299, "1051": 0.6075552701950073, "1996": 0.012615402229130268, "2011": 0.23556606471538544, "2012": 0.04767346754670143, "2015": 0.016465263441205025, "2028": 0.08154398202896118, "2029": 0.259204238653183, "204... | 6472746 | Chromosome segregation during cell division depends on stable attachment of kinetochores to spindle microtubules. Mitotic spindle formation and kinetochore-microtubule (K-MT) capture typically occur within minutes of nuclear envelope breakdown. In contrast, during meiosis I in mouse oocytes, formation of the acentrosom... | Increased CDK1 activity determines the timing of kinetochore-microtubule attachments in meiosis I |
{"1003": 0.26146242022514343, "1012": 0.0029254043474793434, "1013": 0.043007105588912964, "1014": 0.25694093108177185, "1017": 0.09761575609445572, "1018": 0.021256839856505394, "1019": 0.13925230503082275, "1023": 0.14939609169960022, "1054": 0.04394211992621422, "2000": 0.0038986403960734606, "2001": 0.1099398583173... | 6477536 | OBJECTIVE To determine the rate of early discontinuation and non-publication of randomised controlled trials involving patients undergoing surgery. DESIGN Cross sectional observational study of registered and published trials. SETTING Randomised controlled trials of interventions in patients undergoing a surgical proce... | Discontinuation and non-publication of surgical randomised controlled trials: observational study |
{"1017": 0.13071982562541962, "1018": 0.03360854089260101, "1040": 0.07612881064414978, "1056": 1.0512858629226685, "2000": 0.18004031479358673, "2005": 0.1485546976327896, "2011": 0.30558720231056213, "2015": 0.8459017872810364, "2021": 0.3757305145263672, "2030": 0.7314660549163818, "2046": 0.6684301495552063, "2058"... | 6477740 | Direct reprogramming of human somatic cells into induced pluripotent stem (iPS) cells by defined transcription factors (TFs) provides great potential for regenerative medicine and biomedical research. This procedure has many challenges, including low reprogramming efficiency, many partially reprogrammed colonies, somat... | Efficient Generation of Fully Reprogrammed Human iPS Cells via Polycistronic Retroviral Vector and a New Cocktail of Chemical Compounds |
{"1003": 0.2622140049934387, "1018": 0.3269403576850891, "1022": 0.0058422754518687725, "1023": 0.3304552733898163, "1057": 0.1677299439907074, "1059": 0.7086513638496399, "1997": 0.1619328260421753, "2001": 0.08154398202896118, "2012": 0.06429435312747955, "2020": 0.15442965924739838, "2040": 0.6714286804199219, "2043... | 6490571 | CONTEXT Little is known about the extent or severity of untreated mental disorders, especially in less-developed countries. OBJECTIVE To estimate prevalence, severity, and treatment of Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition (DSM-IV) mental disorders in 14 countries (6 less developed, 8 de... | Prevalence, severity, and unmet need for treatment of mental disorders in the World Health Organization World Mental Health Surveys. |
{"1018": 0.1064341589808464, "1023": 0.09938567131757736, "1038": 0.13499516248703003, "1042": 0.9170717000961304, "1043": 0.8143964409828186, "1052": 0.7096124291419983, "2000": 0.22626367211341858, "2001": 0.23864774405956268, "2005": 0.11951763927936554, "2020": 0.22626367211341858, "2034": 0.659380316734314, "2039"... | 6491532 | SETTING Tuberculosis (TB) program, Damien Foundation Projects, Bangladesh. OBJECTIVE To summarize the outcome and its determinants of the first treatment for multidrug-resistant TB using a standardized regimen consisting of a minimum 9 months. DESIGN This was a prospective, observational study of a gatifloxacin (GFX) b... | Successful '9-month Bangladesh regimen' for multidrug-resistant tuberculosis among over 500 consecutive patients. |
{"1009": 0.09761575609445572, "1011": 0.10906458646059036, "1015": 0.2223619967699051, "1018": 0.3824150264263153, "1045": 0.5104349255561829, "1999": 0.9783848524093628, "2008": 0.007782140281051397, "2028": 0.020300358533859253, "2029": 0.14518201351165771, "2031": 0.09406650811433792, "2035": 0.33675122261047363, "2... | 6492658 | Weeble mutant mice have severe locomotor instability and significant neuronal loss in the cerebellum and in the hippocampal CA1 field. Genetic mapping was used to localize the mutation to the gene encoding inositol polyphosphate 4-phosphatase type I (Inpp4a), where a single nucleotide deletion results in a likely null ... | A Null Mutation in Inositol Polyphosphate 4-Phosphatase Type I Causes Selective Neuronal Loss in Weeble Mutant Mice |
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