text stringlengths 0 205 |
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And when I asked him, |
how did you go deaf? |
He said, well, I got |
sick with meningitis. |
And I was so sick that my MD's |
treated me with aminoglycosides |
so that they would kill |
the meningitis bacteria. |
And he isn't sure whether it's |
the meningitis or the side |
effect of the aminoglycosides |
that made him deaf. |
But when you woke up, he |
was cured, but he was deaf. |
So in some cases you're not |
sure which of these agents |
caused the hearing loss. |
So that's a pretty |
complete list now. |
Do we have any questions about |
what things cause hearing loss? |
And you might imagine |
that, during our lifetime, |
some of these things will be |
understood in a better way. |
It's clear why loud sound |
causes hearing loss. |
I mean the mechanical action. |
These things are moving. |
You could damage the |
very sensitive apparatus, |
like the stereocilia. |
Drugs, aminoglycosides |
bind to some |
of the membrane |
channels in hair cells. |
And maybe a therapy for this |
ototoxicity, this hearing loss |
created by these |
aminoglycosides, |
could be to install some |
competitive binder that |
would occupy the binding |
sites while you gave the drug |
therapy. |
We don't know at all what causes |
the hearing loss with aging. |
That's a very active |
subject in today's research. |
Genetic causes, same |
way, usually these |
are some sort of developmental |
factor or protein |
that's necessary for normal hair |
cell development and it's lost, |
in the case of recessive |
genetic problem. |
That's pretty clear |
how that arises. |
Meningitis, it's not clear how |
those diseases kill hair cells, |
but they certainly do. |
But there's certainly |
room to imagine |
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