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tumors that grow |
on various nerves. |
And a very common type |
of tumor in NF2 patients |
is called a |
vestibular schwannoma. |
And a schwannoma is a |
tumor of the schwann cells |
that normally provide the myelin |
covering of peripheral nerves. |
And it grows on the |
vestibular branch |
of the eighth cranial nerve. |
Obviously, that's quite |
near the auditory branch |
of the eighth cranial nerve. |
And these tumors grow and grow. |
They probably rob the |
nerve of the blood supply. |
They probably put |
pressure on it, |
and they certainly |
infiltrate the tumor cells |
in amongst the fibers. |
And when the surgeon goes in |
to remove that type of tumor |
invariably the eighth |
cranial nerve is cut. |
So in that case, the subject |
has no nerve conveying messages |
from the cochlea into the brain. |
Well, the surgery is right here. |
You're removing a |
tumor from here, |
so it's fairly easy to go |
ahead and install an implant |
into the cochlear |
nucleus of the brain. |
The cochlear nucleus is visible. |
And that's what's called an |
auditory brainstem implant. |
It should be called a |
cochlear nucleus implant, |
but it's called an ABI. |
And an ABI-- I'm not going |
to talk too much about it-- |
but just suffice it to say, it's |
an array of surface electrodes. |
There are two |
companies making these. |
One has 15, and one has 21 |
in a checkerboard pattern. |
And the electrodes go onto |
the surface of the cochlear |
nucleus, and their placed |
there during the surgery. |
There was an experimental |
penetrating electrode array, |
or PABI, but that's |
been discontinued |
because of side effects. |
Some of these patients |
got trigeminal neuralgia, |
or pain sensations from nearby |
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