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Structural and kinetic basis for the regulation and potentiation of Hsp104 function. | Hsp104 provides a valuable model for the many essential proteostatic functions performed by the AAA+ superfamily of protein molecular machines. We developed and used a powerful hydrogen exchange mass spectrometry (HX MS) analysis that can provide positionally resolved information on structure, dynamics, and energetics ... | ['Adenosine Triphosphate', 'Amino Acid Substitution', 'Gene Expression Regulation, Fungal', 'Genetic Variation', 'Heat-Shock Proteins', 'Mutation', 'Protein Binding', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins'] | 32,277,033 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['E05.393.420.601.035', 'G05.558.109'], ['G05.308.330'], ['G05.365'], ['D12.776.580.216'], ['G05.365.590'], ['G02.111.679', 'G03.808'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D12.776.354.750']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Galectin-8 regulates targeting of Gp135/podocalyxin and lumen formation at the apical surface of renal epithelial cells. | Establishment of apical-basal polarity, through correct targeting of polarity determinants to distinct domains of the plasma membrane, is a fundamental process for the development of functioning epithelial tubules. Here we report that galectin (Gal)-8 regulates apical-basal polarity of Madin-Darby canine kidney (MDCK) ... | ['Animals', 'Cell Polarity', 'Dogs', 'Epithelial Cells', 'Galectins', 'Kidney', 'Madin Darby Canine Kidney Cells', 'Sialoglycoproteins'] | 28,747,404 | [['B01.050'], ['G04.250'], ['B01.050.150.900.649.313.750.250.216.200'], ['A11.436'], ['D12.776.503.307'], ['A05.810.453'], ['A11.251.210.827', 'A11.436.589'], ['D12.644.233.800', 'D12.776.395.700']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reconsolidation in a human fear conditioning study: a test of extinction as updating mechanism. | Disrupting reconsolidation seems to be a promising approach to dampen the expression of fear memory. Recently, we demonstrated that disrupting reconsolidation by a pharmacological manipulation specifically targeted the emotional expression of memory (i.e., startle response). Here we test in a human differential fear-co... | ['Adolescent', 'Adult', 'Analysis of Variance', 'Conditioning, Classical', 'Electromyography', 'Extinction, Psychological', 'Fear', 'Female', 'Galvanic Skin Response', 'Humans', 'Male', 'Mental Recall', 'Psychiatric Status Rating Scales', 'Reflex, Startle', 'Surveys and Questionnaires', 'Young Adult'] | 21,986,472 | [['M01.060.057'], ['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F02.463.425.179.308'], ['E01.370.405.255', 'E01.370.530.255'], ['F02.463.425.770.232'], ['F01.470.361'], ['E05.796.332', 'F02.830.702.315', 'F04.669.332', 'G07.265.563', 'G13.750.415'], ['B01.050.150.900.649.313.988.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The role of the fat body, midgut and ovary in vitellogenin production and vitellogenesis in the female tick, Dermacentor variabilis. | Polyclonal antibodies directed against D. variabilis vitellin were utilized for immunocytochemistry at the ultrastructural level. We localized vitellogenin (Vg) in rough endoplasmic reticulum cisternae, secretory granules and secreted products of fat body trophocytes and midgut vitellogenic cells from feeding and ovipo... | ['Animals', 'Dermacentor', 'Fat Body', 'Female', 'Immunohistochemistry', 'Microscopy, Electron', 'Ovary', 'Vitellogenesis', 'Vitellogenins'] | 1,639,570 | [['B01.050'], ['B01.050.500.131.166.132.832.400.200'], ['A13.365'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], ['E01.370.350.51... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Interaction of vanadate with the cloned beta cell K(ATP) channel. | Vanadate is used as a tool to trap magnesium nucleotides in the catalytic site of ATPases. However, it has also been reported to activate ATP-sensitive potassium (K(ATP)) channels in the absence of nucleotides. K(ATP) channels comprise Kir6.2 and sulfonylurea receptor subunits (SUR1 in pancreatic beta cells, SUR2A in c... | ['Adenosine Triphosphate', 'Animals', 'Ion Channel Gating', 'Islets of Langerhans', 'Patch-Clamp Techniques', 'Potassium Channels', 'Vanadates', 'Xenopus laevis'] | 10,464,267 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['G02.111.820.400', 'G04.835.400', 'G07.265.625'], ['A03.734.414', 'A06.300.414'], ['E05.200.500.905', 'E05.242.800'], ['D12.776.157.530.400.600', 'D12.776.543.550.450.750', 'D12.776.543.585.400.750'], ['D01.248.497.158.952', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Two new species of Acroceratitis Hendel (Diptera: Tephritidae) and an updated key for the species from India. | Two new species of genus Acroceratitis Hendel, namely A. parastriata David & Hancock , sp. nov. and A. breviscapa David, Ramani & Hancock, sp. nov., are described from India. A. histrionica (de Meijere) is recorded for the first time from India. An updated key to Indian species of Acroceratitis is also provided. | ['Animal Structures', 'Animals', 'Body Size', 'Female', 'India', 'Male', 'Organ Size', 'Tephritidae'] | 25,543,577 | [['A13'], ['B01.050'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['Z01.252.245.393'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['B01.050.500.131.617.720.500.500.750.850']] | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
visGReMLIN: graph mining-based detection and visualization of conserved motifs at 3D protein-ligand interface at the atomic level. | BACKGROUND: Interactions between proteins and non-proteic small molecule ligands play important roles in the biological processes of living systems. Thus, the development of computational methods to support our understanding of the ligand-receptor recognition process is of fundamental importance since these methods are... | ['Humans', 'Hydrogen Bonding', 'Hydrophobic and Hydrophilic Interactions', 'Ligands', 'Protein Binding', 'Proteins', 'User-Computer Interface'] | 32,164,574 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.282'], ['G02.409'], ['D27.720.470.480'], ['G02.111.679', 'G03.808'], ['D12.776'], ['L01.224.900.910']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Replacement of destroyed metacarpal heads by autografting metatarsal heads. | A surgical procedure of replacing a destroyed metacarpal head with a metatarsal graft is described. With this method internal fixation with foreign material as well as postoperative immobilisation can be avoided. A follow up of 25 autotransplantations in rheumatoid patients is presented, showing no complications and fa... | ['Adult', 'Aged', 'Arthritis, Rheumatoid', 'Female', 'Finger Joint', 'Humans', 'Male', 'Metacarpophalangeal Joint', 'Metacarpus', 'Metatarsus', 'Middle Aged', 'Postoperative Complications', 'Radiography', 'Wound Healing'] | 6,512,376 | [['M01.060.116'], ['M01.060.116.100'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['A02.835.583.405.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.405.500'], ['A01.378.800.667.572'], ['A01.378.610.250.300.480'], ['M01.060.116.630'], ['C23.550.767'], ['E01.370.350.700'],... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Patient compliance with tenoxicam in family practice. | This study evaluated factors that may influence patient compliance and also confirmed tolerability and efficacy of tenoxicam in routine clinical practice. Compliance in 1809 patients was evaluated over a 4-week period by physician pill-counts, patient assessment cards, and, for a subpopulation, by electronically monito... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Anti-Inflammatory Agents, Non-Steroidal', 'Arthritis', 'Canada', 'Chronic Disease', 'Double-Blind Method', 'Family Practice', 'Female', 'Humans', 'Male', 'Middle Aged', 'Patient Compliance', 'Piroxicam', 'Prospective Studies'] | 7,923,322 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.696.663.850.014.040.500', 'D27.505.954.158.030', 'D27.505.954.329.030'], ['C05.550.114'], ['Z01.107.567.176'], ['C23.550.291.500'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['H02.403.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Neuropilin-2 expression in papillary thyroid carcinoma: correlation with VEGF-D expression, lymph node metastasis, and VEGF-D-induced aggressive cancer cell phenotype. | CONTEXT: Neuropilin-2 (Nrp2) is a coreceptor for vascular endothelial growth factor-D (VEGF-D) that is expressed on the surface of endothelial cells. Recently, Nrp2 was shown to play a role in lymph node metastasis and promotion of cancer cell migration. VEGF-D also promotes lymphangiogenesis, which in turn promotes tu... | ['Adult', 'Aged', 'Antibodies, Neutralizing', 'Carcinoma, Papillary', 'Cell Line, Tumor', 'Cell Movement', 'Female', 'Humans', 'Lymph Nodes', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neuropilin-2', 'Phenotype', 'Thyroid Neoplasms', 'Vascular Endothelial Growth Factor D'] | 21,880,798 | [['M01.060.116'], ['M01.060.116.100'], ['D12.776.124.486.485.114.244', 'D12.776.124.790.651.114.244', 'D12.776.377.715.548.114.244'], ['C04.557.470.200.360', 'C04.557.470.700.360'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.549.400', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Targeted deletion of betaIII spectrin impairs synaptogenesis and generates ataxic and seizure phenotypes. | The spectrin membrane skeleton controls the disposition of selected membrane channels, receptors, and transporters. In the brain betaIII spectrin binds directly to the excitatory amino acid transporter (EAAT4), the glutamate receptor delta, and other proteins. Mutations in betaIII spectrin link strongly to human spinoc... | ['Animals', 'Ataxia', 'Base Sequence', 'Brain', 'DNA Primers', 'Disease Models, Animal', 'Excitatory Amino Acid Transporter 4', 'Female', 'Gene Targeting', 'Humans', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Knockout', 'Microscopy, Electron, Transmission', 'Nerve Degeneration', 'Phenotype', 'Seizures', 'Spectrin', '... | 20,231,455 | [['B01.050'], ['C10.597.350.090', 'C23.888.592.350.090'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A08.186.211'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D12.776.157.530.200.249.500.500.937', 'D12.776.157.530.450.625.147.937', 'D12... | ['Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Viewing and sectioning the rat's optic nerve using cheap retractors. | A technique for sectioning the optic nerve in rats is described which permits direct viewing of the nerve during surgery. The technique results in no damage to the front of the eye. A procedure for constructing cheap, effective retractors is described. | ['Animals', 'Denervation', 'Nerve Degeneration', 'Ophthalmologic Surgical Procedures', 'Optic Nerve', 'Optic Nerve Injuries', 'Rats', 'Surgical Instruments', 'Visual Pathways'] | 14,677,600 | [['B01.050'], ['E04.525.210'], ['C23.550.737'], ['E04.540'], ['A08.800.800.120.680'], ['C10.292.200.750', 'C10.292.700.475', 'C10.900.300.218.550', 'C11.640.530', 'C26.915.300.400.650'], ['B01.050.150.900.649.313.992.635.505.700'], ['E07.858.700'], ['A08.612.220.860']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An assessment of the in vivo efficacy of the glycogen phosphorylase inhibitor GPi688 in rat models of hyperglycaemia. | BACKGROUND AND PURPOSE: Studies in cultured hepatocytes demonstrate glycogen synthase (GS) activation with glycogen phosphorylase (GP) inhibitors. The current study investigated whether these phenomena occurred in vivo using a novel GP inhibitor.EXPERIMENTAL APPROACH: An allosteric GP inhibitor, GPi688, was evaluated a... | ['Animals', 'Blood Glucose', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Glucagon', 'Glucose', 'Glucose Tolerance Test', 'Glycogen Phosphorylase', 'Glycogen Synthase', 'Hepatocytes', 'Hyperglycemia', 'Inhibitory Concentration 50', 'Male', 'Obesity', 'Quinolones', 'Rats', 'Rats, Wistar', 'Rats, Zucker... | 17,934,512 | [['B01.050'], ['D09.947.875.359.448.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G07.690.773.875', 'G07.690.936.500'], ['D06.472.699.587.730.500', 'D12.644.548.586.730.500'], ['D09.947.875.359.448'], ['E01.370.225.124.100.355', 'E01.370.374.355', 'E05.200.124.100.355'], ['D08.811.913.400.450.460.400.186'], [... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antiprotozoal properties of 16,17-dihydrobrachycalyxolide from Vernonia brachycalyx. | Extracts of the leaves from Vernonia brachycalyx showed in vitro activity against Plasmodium falciparum and promastigotes of Leishmania major. The germacrane dilactone 16,17-dihydrobrachycalyxolide (1) which was previously isolated from the aerial parts of the plant was shown to be the major antiplasmodial principle. A... | ['Animals', 'Antiprotozoal Agents', 'Cell Survival', 'Humans', 'Leishmania major', 'Lymphocytes', 'Models, Molecular', 'Molecular Conformation', 'Molecular Structure', 'Plant Extracts', 'Plant Leaves', 'Plants, Medicinal', 'Sesquiterpenes, Germacrane'] | 9,741,304 | [['B01.050'], ['D27.505.954.122.250.100'], ['G04.346'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.268.475.868.488.405'], ['A11.118.637.555.567', 'A15.145.229.637.555.567', 'A15.382.490.555.567'], ['E05.599.595'], ['G02.111.570.820'], ['G02.111.570', 'G02.466'], ['D20.215.784.500', 'D26.667'], ['A18.024.812... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lower-body determinants of running economy in male and female distance runners. | A variety of training approaches have been shown to improve running economy in well-trained athletes. However, there is a paucity of data exploring lower-body determinants that may affect running economy and account for differences that may exist between genders. Sixty-three male and female distance runners were assess... | ['Achilles Tendon', 'Adolescent', 'Arm', 'Biomechanical Phenomena', 'Exercise Test', 'Female', 'Gait', 'Humans', 'Kinetics', 'Leg', 'Male', 'Movement', 'Oxygen Consumption', 'Running', 'Sex Factors', 'Young Adult'] | 24,126,900 | [['A02.880.176'], ['M01.060.057'], ['A01.378.800.075'], ['G01.154.090', 'G01.374.089'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['E01.370.600.250', 'G11.427.410.568.900.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['A01.378.610.500'], ['G07.568', 'G11.42... | ['Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Estimation of potential arsenic leaching from its phases in excavated sedimentary and metamorphic rocks. | It is important that hazardous excavated sedimentary and metamorphic rocks are treated appropriately and reused without posing an environmental risk. Up-flow column leaching tests were conducted to examine whether arsenic leaching behavior varied among five hazardous excavated sedimentary and metamorphic rocks (two mud... | ['Arsenic', 'Geologic Sediments', 'Minerals', 'Soil Pollutants', 'Solubility'] | 31,300,943 | [['D01.268.513.249'], ['G01.311.330', 'G16.500.320'], ['D01.578'], ['D27.888.284.756'], ['G02.805']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gender Equality, Patriarchal Cultural Norms, and Perpetration of Intimate Partner Violence: Comparison of Male University Students in Asian and European Cultural Contexts. | This study examined the relationship between patriarchal cultural norms and violence perpetration by male partners using a subsample of university students in Asia ( n = 784) and Europe ( n = 575) from the International Dating Violence Study (IDVS) data set. Bivariate analyses indicated Asian students scored significan... | ['Adult', 'Asia', 'Cultural Characteristics', 'Europe', 'Family Characteristics', 'Humans', 'Interpersonal Relations', 'Intimate Partner Violence', 'Male', 'Sexism', 'Students', 'Universities'] | 27,378,719 | [['M01.060.116'], ['Z01.252'], ['I01.076.201.450.324', 'I01.880.853.100.329'], ['Z01.542'], ['F01.829.263.315', 'I01.240.361', 'I01.880.853.150.423', 'N01.224.361', 'N01.824.308', 'N06.850.505.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['I01.198.240.856.575', 'I01.880.735.900.688'], ['... | ['Named Groups [M]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Increased aortic stiffness and attenuated lysyl oxidase activity in obesity. | OBJECTIVE: One potential mechanism through which obesity exerts adverse effects on the vascular system is by increasing aortic stiffness, a change known to be predictive of increased cardiovascular mortality. The aim of this study was to investigate the pathophysiology that links obesity to aortic stiffening.APPROACH A... | ['Adipocytes', 'Adipose Tissue', 'Adult', 'Aminopropionitrile', 'Animals', 'Aorta, Abdominal', 'Case-Control Studies', 'Cell Line', 'Culture Media, Conditioned', 'Cytokines', 'Disease Models, Animal', 'Dose-Response Relationship, Drug', 'Down-Regulation', 'Elastic Modulus', 'Elastin', 'Enzyme Inhibitors', 'Female', 'Hu... | 23,413,430 | [['A11.329.114'], ['A10.165.114'], ['M01.060.116'], ['D02.626.151'], ['B01.050'], ['A07.015.114.056.205'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A11.251.210'], ['D27.720.470.305.250', 'E07.206.250'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C22.232', 'E05.598.5... | ['Anatomy [A]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The in vitro effect of monensin on BK polyomavirus replication. | The in vitro effect of monensin, a linear polyether, on the infection of Vero cells by BK polyomavirus, was investigated. Data reported in this paper showed an inhibition of BK viral replication by monensin as monitored by immunofluorescence and molecular hybridization. The inhibition of the synthesis of viral nuclear ... | ['Animals', 'Antigens, Viral, Tumor', 'BK Virus', 'Chlorocebus aethiops', 'Humans', 'Ionophores', 'Kinetics', 'Monensin', 'RNA, Messenger', 'RNA, Viral', 'Transcription, Genetic', 'Vero Cells', 'Virus Replication'] | 8,590,386 | [['B01.050'], ['D23.050.285.062', 'D23.050.327.062'], ['B04.280.210.700.615.100', 'B04.613.204.670.615.100'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.519.562.374', 'D27.720.395'], ['G01.374.661', 'G02.111.490'], ['D03.383.312.600'], ['D13.444.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of EHD4, an EH domain-containing protein expressed in the extracellular matrix. | To identify proteins that promote assembly of type VI collagen tetramers or stabilize type VI collagen filaments, a two-hybrid screen of a human placenta library was used and a new extracellular protein discovered. The cDNA sequence of the new protein encodes 541 amino acid residues. This cDNA sequence is identical to ... | ['3T3 Cells', 'Amino Acid Sequence', 'Animals', 'Base Sequence', 'Blotting, Northern', 'Blotting, Western', 'Carrier Proteins', 'Cartilage', 'Cattle', 'Cells, Cultured', 'Chromosome Mapping', 'Chromosomes, Human, Pair 15', 'Collagen', 'Collagen Type IV', 'DNA, Complementary', 'DNA-Binding Proteins', 'Electrophoresis, P... | 11,533,061 | [['A11.251.210.100', 'A11.329.228.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D12.7... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
[Activities in social gynaecology for prepartal - prenatal attention (author's transl)]. | An account is given of what is being done in the GDR in the context of social gynaecology, with reference being made to the subject proper as well as to its position in society and the tasks relating to it. Prepartal attention is described as an example. An appraisal of various concepts of social gynaecology has shown ... | ['Female', 'Germany, East', 'Humans', 'Maternal Health Services', 'Pregnancy', 'Prenatal Care'] | 532,443 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tangeretin Inhibits Oxidative Stress and Inflammation via Upregulating Nrf-2 Signaling Pathway in Collagen-Induced Arthritic Rats. | BACKGROUND/AIMS: Tangeretin (TAN), a major phytochemical in tangerine peels and an important Chinese herb, has multiple biological properties, especially antioxidative and anti-inflammatory effects. However, the mechanisms remain unclear. Based on these findings, the aim of the present study was to assess the antioxida... | ['Animals', 'Anti-Inflammatory Agents', 'Antioxidants', 'Arthritis, Experimental', 'Arthritis, Rheumatoid', 'Catalase', 'Collagen', 'Cytokines', 'Dinoprostone', 'Flavones', 'Glutathione', 'Inflammation', 'Interleukin-10', 'Interleukin-1beta', 'Joints', 'Lipid Peroxidation', 'Male', 'NF-E2-Related Factor 2', 'Nitric Oxi... | 31,344,704 | [['B01.050'], ['D27.505.954.158'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['C05.550.114.015', 'E05.598.500.249'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['D08.811.682.732.332'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D12.644.276.374', 'D12.776.467.374', 'D23... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dendritic cell-associated B7-H3 suppresses the production of autoantibodies and renal inflammation in a mouse model of systemic lupus erythematosus. | B7-H3 immune modulatory molecule has been implicated in the generation and pathogenesis of autoimmune diseases, the mechanism of action is less known. We explored the role of B7-H3 in the induction of autoantibodies and organ-directed inflammation in a murine systemic lupus erythematosus (SLE) model in which the immuni... | ['Animals', 'Antibodies', 'Antibodies, Antinuclear', 'Autoantibodies', 'B7 Antigens', 'CD4-Positive T-Lymphocytes', 'DNA', 'Dendritic Cells', 'Disease Models, Animal', 'Female', 'Glomerulonephritis', 'Interleukin-6', 'Kidney', 'Lupus Erythematosus, Systemic', 'Lymphocyte Activation', 'Mice', 'Mice, Inbred C57BL', 'Mice... | 31,113,935 | [['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['D12.776.124.486.485.114.323.204', 'D12.776.124.790.651.114.323.204', 'D12.776.377.715.548.114.323.204'], ['D12.776.124.486.485.114.323', 'D12.776.124.790.651.114.323', 'D12.776.377.715.548.114.323'], ['D12.776.467.150', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[New paradigms in mental health and the vision from music therapy]. | This paper aims to describe the vision of mental health from the standpoint of music therapy, framed by the National Law 26.567. First, basic notions about the origins of this discipline are introduced, as well as the criteria that inform its practice and the tools used by this approach, listening, analysis and the int... | ['Creativity', 'Humans', 'Mental Disorders', 'Mental Health', 'Music Therapy'] | 22,880,198 | [['F01.752.264', 'F02.463.785.302'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03'], ['F02.418', 'N01.400.500'], ['E02.190.888.500', 'E02.760.169.063.500.440', 'E02.831.440', 'F04.754.549']] | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Nature and nurture in the family physician's choice of practice location. | INTRODUCTION: An understanding of the contextual, professional, and personal factors that affect choice of practice location for physicians is needed to support successful strategies in addressing geographic maldistribution of physicians. This study compared two categories of predictors of family practice location in n... | ['Attitude', 'Canada', 'Choice Behavior', 'Education, Medical, Undergraduate', 'Family Practice', 'Female', 'Humans', 'Male', 'Physicians, Family', 'Professional Practice Location', 'Retrospective Studies', 'Rural Health Services', 'Rural Population', 'Workforce', 'Young Adult'] | 21,919,544 | [['F01.100'], ['Z01.107.567.176'], ['F02.463.785.373.346'], ['I02.358.399.450'], ['H02.403.340.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.810.770', 'N02.360.810.770'], ['N04.452.758.772'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.5... | ['Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Between- and within-observer agreement for expert judgment of peak flow graphs from a working population. | Expert judgment of peak flow-time graphs provides an important tool to detect occupational asthma. This technique has mainly been used in clinics to evaluate reversible airflow obstruction and to assess potential work-related patterns. The reproducibility of this technique in an open working population is unknown. Agre... | ['Adult', 'Asthma', 'Food Technology', 'Humans', 'Middle Aged', 'Netherlands', 'Observer Variation', 'Occupational Diseases', 'Peak Expiratory Flow Rate', 'Reproducibility of Results', 'Solanum tuberosum', 'Time Factors'] | 9,830,603 | [['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['J01.576.423.850'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.542.651'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['C24'], ['E01.370.386.700.660.225.600... | ['Named Groups [M]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 |
[A double blind study of the treatment of threatened abortion with fenoterol hydrobromide (author's transl)]. | UNLABELLED: To study the effectiveness of Fenoterol Hydrobromide in the treatment of threatened abortion a double blind trial was performed. A total of 112 patients was examined. A comprehensive statistical analysis was made including Chi square and Student's t-test to provide a valid comparison of both, trial and cont... | ['Abortion, Threatened', 'Double-Blind Method', 'Ethanolamines', 'Female', 'Fenoterol', 'Humans', 'Infant, Newborn', 'Placebos', 'Pregnancy'] | 7,215,765 | [['C13.703.090'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D02.033.100.291', 'D02.033.375.291', 'D02.092.063.291'], ['D02.033.100.291.465.300', 'D02.092.063.291.465.300', 'D02.092.311.660.300', 'D02.455.426.559.389.657.166.175.660.300'], ['B01.050.150.900.649.313.988.400.1... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The course of negative symptoms over the first five years of treatment: Data from an early intervention program for psychosis. | BACKGROUND: Cross-sectional studies suggest that negative symptoms are constituted by separable domains of reduced expressiveness and reduced motivation, but there is little data on the longitudinal course of these symptoms. We examined evidence for differences in the course and correlates of these two domains in a pro... | ['Basal Ganglia Diseases', 'Cognition Disorders', 'Cross-Sectional Studies', 'Early Intervention, Educational', 'Electroencephalography', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Mood Disorders', 'Psychotic Disorders'] | 26,431,791 | [['C10.228.140.079'], ['F03.615.250'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N02.421.143.130.320', 'N02.421.726.320'], ['E01.370.376.300', 'E01.370.405.245'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.9... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Maternal onset de novo SH2D1A mutation and lymphocytic choriomeningitis virus infection in a patient with X‑linked lymphoproliferative disease type 1: a case report. | X‑linked lymphoproliferative disease type 1 (XLP1) is a rare genetic immunodeficiency disease, which occurs due to germline mutations in the SH2D1A gene. This gene has been reported to encode the adaptor molecule signaling lymphocytic activation molecule‑associated protein XLP1 is generally triggered by the Epstein‑Bar... | ['Child, Preschool', 'DNA Mutational Analysis', 'Genes, X-Linked', 'Humans', 'Intracellular Signaling Peptides and Proteins', 'Lymphocytic Choriomeningitis', 'Lymphocytic choriomeningitis virus', 'Lymphoproliferative Disorders', 'Male', 'Mutation', 'Pedigree', 'Radiography, Thoracic', 'Signaling Lymphocytic Activation ... | 25,572,984 | [['M01.060.406.448'], ['E05.393.760.700.300'], ['G05.360.340.024.340.500', 'G05.420.457'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.360', 'D12.776.476'], ['C01.207.245.500.500', 'C01.925.182.550.500', 'C01.925.782.082.580', 'C10.228.228.245.500.500', 'C10.228.614.400.500'], ['B04.820.480.500.070.100.5... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Prevalence and risk factors of Helicobacter pylori infection in Tunisian children: 1055 children in Cap-Bon (northeastern Tunisia). | PURPOSE: The aim of this study was to determine the prevalence of Helicobacter pylori infection in a population of schoolchildren six years of age and to identify the risk factors that predispose children to such infection.PATIENTS AND METHODS: A total of 1055 first-grade primary-school pupils were included. Socioecono... | ['Child', 'Female', 'Helicobacter Infections', 'Helicobacter pylori', 'Humans', 'Male', 'Prevalence', 'Risk Factors', 'Tunisia'] | 18,691,841 | [['M01.060.406'], ['C01.150.252.400.466'], ['B03.440.500.550', 'B03.660.150.235.500.250.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.36... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Midterm results of surgical treatment of systemic ventricular outflow obstruction in Fontan patients. | BACKGROUND: Achieving unobstructed blood flow from the systemic ventricle to the aorta is important during the Fontan procedure for complex cyanotic congenital heart disease when there is systemic ventricular outflow obstruction (SVOO). Because SVOO can progress after the Fontan procedure if there is morphologic obstru... | ['Adolescent', 'Anastomosis, Surgical', 'Cardiac Surgical Procedures', 'Child', 'Child, Preschool', 'Fontan Procedure', 'Heart Defects, Congenital', 'Humans', 'Infant', 'Treatment Outcome', 'Ventricular Outflow Obstruction'] | 11,899,191 | [['M01.060.057'], ['E04.035'], ['E04.100.376', 'E04.928.220'], ['M01.060.406'], ['M01.060.406.448'], ['E04.035.410.295', 'E04.100.376.410.295', 'E04.100.376.724.500', 'E04.100.814.868.875.295', 'E04.928.220.370.295', 'E04.928.220.560.500'], ['C14.240.400', 'C14.280.400', 'C16.131.240.400'], ['B01.050.150.900.649.313.98... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The mTOR effectors 4EBP1 and S6K2 are frequently coexpressed, and associated with a poor prognosis and endocrine resistance in breast cancer: a retrospective study including patients from the randomised Stockholm tamoxifen trials. | INTRODUCTION: mTOR and its downstream effectors the 4E-binding protein 1 (4EBP1) and the p70 ribosomal S6 kinases (S6K1 and S6K2) are frequently upregulated in breast cancer, and assumed to be driving forces in tumourigenesis, in close connection with oestrogen receptor (ER) networks. Here, we investigated these factor... | ['Adaptor Proteins, Signal Transducing', 'Antineoplastic Agents, Hormonal', 'Breast Neoplasms', 'Cell Cycle Proteins', 'Drug Resistance, Neoplasm', 'Female', 'Gene Amplification', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Patient Outcome Assessment', 'Phosphoproteins', 'Prognosis', 'RNA, Messenger', 'Recurre... | 24,131,622 | [['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['D27.505.954.248.169'], ['C04.588.180', 'C17.800.090.500'], ['D12.776.167'], ['G07.690.773.984.395'], ['G05.308.250', 'G05.365.590.310', 'G05.558.315'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N04.761.559.590.399', 'N05.715.360.575... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Case-finding for MS prevalence studies in small communities requires a community-based approach. | In response to citizen concerns in 5 small Illinois towns, community-based case-finding determined the prevalence of multiple sclerosis (MS). Potential cases were identified through town meetings, publicity, advocacy groups and local volunteer outreach coordinators. Estimated prevalence based on available medical recor... | ['Case-Control Studies', 'Female', 'Humans', 'Male', 'Medical Records', 'Multiple Sclerosis', 'Prevalence', 'Registries', 'Residence Characteristics'] | 17,878,739 | [['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.940.968', 'N04.452.859.564', 'N05.715.360.300.715.500', 'N06.850.520.308.940.968'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500'], ['E05.318.308.985.525.750', 'N... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cognitive decline and education in mild dementia. | Recent studies suggested that education may modify the clinical expression of dementia and Alzheimer's disease through its association with a brain reserve capacity. We studied whether education would be related to degree of cognitive decline in mild dementia. Equations to estimate premorbid cognitive ability were deri... | ['Aged', 'Aged, 80 and over', 'Cognition Disorders', 'Dementia', 'Educational Status', 'Female', 'Humans', 'Male', 'Neuropsychological Tests'] | 9,443,477 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['F03.615.250'], ['C10.228.140.380', 'F03.615.400'], ['N01.824.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.513']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The epidemic origin and molecular properties of B': a founder strain of the HIV-1 transmission in Asia. | OBJECTIVE: To clarify the epidemic origin and molecular properties of the B' subtype that is an important strain in the HIV-1 epidemic in Asia.DESIGN: The genealogical relationship between the B' and B subtype was investigated with two globally representative datasets covering the gag and env regions. B' sequences were... | ['Amino Acid Sequence', 'Asia', 'Base Sequence', 'Disease Outbreaks', 'Evolution, Molecular', 'Genes, env', 'Genes, gag', 'Genetic Variation', 'HIV Envelope Protein gp120', 'HIV Infections', 'HIV-1', 'Humans', 'Molecular Epidemiology', 'Molecular Sequence Data', 'Phylogeny'] | 18,753,865 | [['G02.111.570.060', 'L01.453.245.667.060'], ['Z01.252'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['N06.850.290'], ['G05.045.250', 'G16.075.250'], ['G05.360.340.024.340.364.875.172', 'G05.360.340.358.024.875.172', 'G05.360.340.358.840.500.172'], ['G05.360.340.024.340.364.875.258', 'G05.360.340.358.02... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Geographicals [Z]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Continuous monitoring of in vivo nitric oxide formation using EPR analysis in biliary flow. | A method to continuously monitor the nitric oxide (NO) level in anesthetized rats, using an in vivo trapping reaction of NO by iron-dithiocarbamate complex, is reported. Previously, we developed a method of monitoring NO in bile samples containing an NO complex excreted from the liver (Anal. Biochem. 243, 8-14, 1996). ... | ['Animals', 'Arginine', 'Bile', 'Cyclic N-Oxides', 'Electron Spin Resonance Spectroscopy', 'Enzyme Inhibitors', 'Gamma Rays', 'Kinetics', 'Lipopolysaccharides', 'Male', 'NG-Nitroarginine Methyl Ester', 'Nitric Oxide', 'Nitric Oxide Synthase', 'Nitrogen Oxides', 'Rats', 'Rats, Sprague-Dawley', 'Whole-Body Irradiation'] | 10,369,181 | [['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['A12.200.087'], ['D03.661.243'], ['E05.196.867.519.274'], ['D27.505.519.389'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['G01.374.661', 'G02.111.490'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D2... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Emtricitabine seminal plasma and blood plasma population pharmacokinetics in HIV-infected men in the EVARIST ANRS-EP 49 study. | We aimed to describe blood plasma (BP) and seminal plasma (SP) pharmacokinetics of emtricitabine (FTC) in HIV-1-infected men, assess its penetration in the male genital tract, and evaluate its impact on seminal plasma HIV load (spVL) detection. Men from the EVARIST ANRS EP49 study receiving combined antiretroviral ther... | ['Adult', 'Anti-HIV Agents', 'Emtricitabine', 'HIV Infections', 'Humans', 'Male', 'Middle Aged', 'Plasma', 'Semen'] | 26,282,407 | [['M01.060.116'], ['D27.505.954.122.388.077.088'], ['D03.383.742.680.245.500.600', 'D13.570.230.329.525', 'D13.570.685.245.500.600'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
N-butanol extracts of Morinda citrifolia suppress advanced glycation end products (AGE)-induced inflammatory reactions in endothelial cells through its anti-oxidative properties. | BACKGROUND: Advanced glycation end products (AGEs), senescent macroprotein derivatives formed during a normal aging process and acceleratedly under diabetic conditions, play a role in atherosclerotic cardiovascular disease. AGEs cause endothelial cell (EC) damage, an initial trigger for atherosclerosis through the inte... | ['1-Butanol', 'Antioxidants', 'Cell Line, Tumor', 'Endothelial Cells', 'Glycation End Products, Advanced', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'Morinda', 'Plant Extracts'] | 28,259,164 | [['D02.033.415.110.175', 'D10.289.110.175'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.436.275'], ['D12.776.643.500'], ['A11.436.275.682'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.650.940.800.575.912.250.456.937.566'], ['D20.215.784.500',... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evidence of impaired sense of smell in hereditary angioedema. | BACKGROUND: Hereditary angioedema (HAE) is an autosomal-dominant disorder resulting from C1-inhibitor (C1INH) deficiency. Smell impairments were found in patients affected with systemic lupus erythematosus, that, similarly to HAE, is characterized by the activation of the classical complement pathway with C4 consumptio... | ['Adult', 'Angioedemas, Hereditary', 'Case-Control Studies', 'Complement C1 Inhibitor Protein', 'Complement C4', 'Complement Hemolytic Activity Assay', 'Complement Pathway, Classical', 'Female', 'Humans', 'Lupus Erythematosus, Systemic', 'Male', 'Middle Aged', 'Olfaction Disorders', 'Smell'] | 20,649,895 | [['M01.060.116'], ['C14.907.079.500', 'C16.320.798.500.500', 'C17.800.862.945.066.500', 'C20.543.480.904.066.500', 'C20.673.795.500.500'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D12.644.861.140.500', 'D12.776.124.486.274.920.250.500', 'D12.776.395.320', 'D12.776.872.140.500'], ... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The distribution of S-100 protein in hyperplastic and neoplastic prostatic epithelium. | Specimens from 30 cases of benign prostatic hyperplasia and 75 cases of prostatic carcinoma obtained during suprapubic prostatectomy, transurethal resection of the prostate and radical prostatectomy, were stained immunohistochemically for S-100 protein, prostatic acid phosphatase (PAP), prostatic specific antigen (PSA)... | ['Epithelium', 'Humans', 'Male', 'Prostatic Hyperplasia', 'Prostatic Neoplasms', 'S100 Proteins'] | 11,229,645 | [['A10.272'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.565.500'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['D12.776.157.125.750', 'D12.776.631.655']] | ['Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differential spontaneous folding of mycolic acids from Mycobacterium tuberculosis. | Mycolic acids are structural components of the mycobacterial cell wall that have been implicated in the pathogenicity and drug resistance of certain mycobacterial species. They also offer potential in areas such as rapid serodiagnosis of human and animal tuberculosis. It is increasingly recognized that conformational b... | ['Hydrophobic and Hydrophilic Interactions', 'Molecular Conformation', 'Molecular Dynamics Simulation', 'Mycobacterium tuberculosis', 'Mycolic Acids', 'Principal Component Analysis', 'Surface Properties', 'Thermodynamics'] | 24,362,064 | [['G02.409'], ['G02.111.570.820'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['B03.510.024.962.500.702', 'B03.510.460.400.410.552.552.702'], ['D02.241.511.621', 'D10.251.572'], ['E05.318.740.562'], ['G02.860'], ['G01.906']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Global profiling of the circadian transcriptome using microarrays. | Circadian rhythms are biological cycles with a period length of approximately 24 h that are generated by endogenous clocks. The application of microarrays for high-throughput transcriptome analysis has led to the insight that substantial portions of the transcriptomes of both humans and many model organisms are clock-r... | ['Algorithms', 'Circadian Clocks', 'Computational Biology', 'Gene Expression Profiling', 'Transcriptome'] | 24,792,043 | [['G17.035', 'L01.224.050'], ['G07.180.562.094.500'], ['H01.158.273.180', 'L01.313.124'], ['E05.393.332'], ['G02.111.873.750', 'G05.297.700.750', 'G05.360.920']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Syphilitic lymphadenopathy. Histology and human immunodeficiency virus status. | Few reports on syphilitic lymphadenopathy have appeared in 20 years, and none have compared findings in patients with and without human immunodeficiency virus (HIV) infection, despite the recent epidemic spread of syphilis and HIV. Twelve cases of syphilitic lymphadenopathy were studied and grouped according to HIV sta... | ['Adult', 'Female', 'HIV Seronegativity', 'HIV Seropositivity', 'Humans', 'Immunohistochemistry', 'Lymphatic Diseases', 'Male', 'Middle Aged', 'Retrospective Studies', 'Syphilis'] | 10,478,137 | [['M01.060.116'], ['G12.400'], ['C01.221.250.875.500', 'C01.221.812.640.400.500', 'C01.778.640.400.500', 'C01.925.782.815.616.400.500', 'C01.925.813.400.500', 'C20.673.480.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.5... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
FSH receptor gene polymorphisms in fertile and infertile Italian men. | In women, single nucleotide polymorphisms (SNP) of the FSH receptor (FSHR) gene influence FSH concentrations and the sensitivity of the FSHR to FSH in vivo. In contrast, the significance of FSHR R gene SNP in the male is poorly understood. To this aim, the possible role of three FSHR SNP was evaluated in male infertili... | ['Alleles', 'Base Sequence', 'DNA', 'Exons', 'Female', 'Fertility', 'Follicle Stimulating Hormone, Human', 'Humans', 'Infertility, Male', 'Italy', 'Male', 'Oligospermia', 'Polymorphism, Single Nucleotide', 'Promoter Regions, Genetic', 'Receptors, FSH'] | 17,169,197 | [['G05.360.340.024.340.030'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308'], ['G05.360.340.024.340.137.232'], ['G08.686.210'], ['D06.472.699.631.525.343.288.625'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.365.700'], ['Z01.542.489'], ['C12.294.365.700.508'], ['G05.365.795.5... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Benign vascular tumours of the Mediastinum: presentation of three cases and review of the literature. | Two patients with epithelioid haemangioendothelioma and one patient with multiple cavernous haemangiomas of the mediastinum, pharynx and larynx, are herein presented. Haemothorax as initial manifestation of the tumour was observed in one of them. Epithelioid haemangioendotheliomas were radically removed in both cases. ... | ['Adolescent', 'Adult', 'Antineoplastic Agents, Hormonal', 'Female', 'Hemangioendothelioma, Epithelioid', 'Hemangioma, Cavernous', 'Humans', 'Laryngeal Neoplasms', 'Mediastinal Neoplasms', 'Pharyngeal Neoplasms', 'Prednisolone', 'Radiography'] | 8,775,864 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.248.169'], ['C04.557.645.375.370.380'], ['C04.557.645.375.385', 'C14.907.454.385', 'C15.378.463.515.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.443.665.481', 'C08.360.369', 'C08.785.481', 'C09.400.369', 'C09.647.481'], ['C04.588.894.479', 'C08.846.1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Comparison of the effects of pharmacological therapy and a low-sodium diet on mild hypertension. | 1. The effect of a low-sodium diet and pharmacological therapy has been compared in eighty-one patients with mild hypertension. 2. Both pharmacological therapy and a low-sodium diet reduced lying and standing systolic and diastolic blood pressure significantly. | ['Adult', 'Aged', 'Chlorthalidone', 'Clonidine', 'Humans', 'Hypertension', 'Middle Aged', 'Sodium Chloride'] | 1,071,693 | [['M01.060.116'], ['M01.060.116.100'], ['D02.065.884.365', 'D02.455.426.559.389.134.500', 'D02.478.600.500', 'D02.522.223.500', 'D02.886.590.700.365', 'D03.633.100.513.750.500'], ['D03.383.129.308.436.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.907.489'], ['M01.060.116.630'], ['D01.210.450.150.875', '... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Premenstrual mastodynia: objective signs (author's transl)]. | Mammary congestion is mainly a painful syndrome, principally related to diffuse edema of the gland, the radiological signs of which are described in this report. Excellent validity can be obtained by a trained observer of these signs. In contrast, however, thermographic signs are of less value, probably due to the pres... | ['Adult', 'Breast Diseases', 'Female', 'Humans', 'Mammography', 'Menstruation', 'Middle Aged', 'Pain', 'Progesterone', 'Prolactin', 'Thermography'] | 536,962 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The observation of local immune response in the lungs from antigen-sensitized and challenged mice]. | OBJECTIVE: To evaluate the local immune response after allergic sensitization and challenge in the lungs of mice.METHODS: C57BL/6 mice were sensitized with keyhole limpet hemocyanin (KLH) by intratracheal instillation and challenged 2 approximately 4 weeks later. Bronchoalveolar lavage fluid (BALF) and plasma were coll... | ['Animals', 'Antibodies', 'Enzyme-Linked Immunosorbent Assay', 'Hemocyanins', 'Immunoglobulin A', 'Lung', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Spleen'] | 11,953,113 | [['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D12.776.093.375', 'D12.776.556.462', 'D23.767.482'], ['D12.776.124.486.485.114.619.026', 'D12.776.124.79... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Ocular complications of porphyria. A case of G?nther's disease]. | On a case of G?nther congenital porphyria with late ophthalmic complications, the authors study clinical and haematological manifestations of this disease (clinical signs are related to light sensibilisation: sclerodactily, hyperpigmentation, non cicatrisating wounds, long standing scars of reposed areas; they begin in... | ['Adolescent', 'Adult', 'Child', 'Child, Preschool', 'Eye Diseases', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Liver Diseases', 'Male', 'Middle Aged', 'Photosensitivity Disorders', 'Porphyrias', 'Skin Diseases'] | 7,169,506 | [['M01.060.057'], ['M01.060.116'], ['M01.060.406'], ['M01.060.406.448'], ['C11'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C06.552'], ['M01.060.116.630'], ['C17.800.600'], ['C18.452.811'], ['C17.800']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Children who become active. | OBJECTIVES: This article examines factors associated with children aged 4 to 11 becoming and remaining active, and how this differed according to their weight.DATA SOURCE: The data are from the National Longitudinal Survey of Children and Youth: cycle 1 (1994/95) for the cross-sectional analysis, and cycles 1, 2 and 3 ... | ['Body Mass Index', 'Canada', 'Child', 'Child Welfare', 'Child, Preschool', 'Exercise', 'Family Characteristics', 'Female', 'Health Behavior', 'Health Promotion', 'Humans', 'Longitudinal Studies', 'Male', 'Obesity', 'Physical Education and Training', 'Prevalence', 'Socioeconomic Factors', 'Television'] | 14,768,291 | [['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['Z01.107.567.176'], ['M01.060.406'], ['I01.880.787.293'], ['M01.060.406.448'], ['G11.427.410.698.277', 'I03.350'], ['F01.829.263.315', 'I01.240.361', 'I01.880.853.150.423', 'N01.224.361', 'N01.824.308', 'N06.850.505.400.400'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Technology, Industry, and... | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 1 |
Distinctive regulation of contact activation by antithrombin and C1-inhibitor on activated platelets and material surfaces. | Activated human plate lets trigger FXII-mediated contact activation, which leads to the generation of FXIIa-antithrombin (AT) and FXIa-AT complexes. This suggests that contact activation takes place at different sites, on activated platelets and material surfaces, during therapeutic procedures involving biomaterials in... | ['Antithrombins', 'Biocompatible Materials', 'Blood Platelets', 'Complement C1 Inactivator Proteins', 'Enzyme-Linked Immunosorbent Assay', 'Humans', 'Platelet Activation', 'Thrombospondin 1'] | 19,783,299 | [['D27.505.519.389.745.800.449', 'D27.505.954.502.119.500'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['A11.118.188', 'A15.145.229.188'], ['D12.644.861.140', 'D12.776.124.486.274.920.250', 'D12.776.872.140'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Some safety aspects of Salmonella vaccines for poultry: in vivo study of the genetic stability of three Salmonella typhimurium live vaccines. | Live vaccine strains of Salmonella should be avirulent, immunogenic and genetically stable. Some isolates of three commercially available live vaccine strains of Salmonella typhimurium, sampled during a study on their persistence in a vaccinated flock of chickens, were analyzed for genetic stability using macrorestrict... | ['Animals', 'Bacteriophage Typing', 'Chickens', 'Deoxyribonucleases, Type II Site-Specific', 'Electrophoresis, Gel, Pulsed-Field', 'Genotype', 'Poultry Diseases', 'Restriction Mapping', 'Salmonella Infections, Animal', 'Salmonella Vaccines', 'Salmonella typhimurium', 'Vaccines, Attenuated'] | 11,040,436 | [['B01.050'], ['E01.370.225.875.150.125.150', 'E05.200.875.150.125.150'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['D08.811.150.280.260', 'D08.811.277.352.335.350.300.260', 'D08.811.277.352.355.325.300.260'], ['E05.196.401.220', 'E05.301.300.220'], ['G05.380'], ['C22.131.728'], ['E05.393.183.620... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Recent trends in specular light reflectance beyond clinical fluorescence diagnosis. | Under specific light illumination, particularly ultraviolet (UV) and near-UV light stimulation, the skin produces both specular light reflectance and, possibly, specific fluorescent emission. These properties offer diagnostic clues and disclose some peculiar functions of the skin. A series of superficial infections (er... | ['Dermatology', 'Dermoscopy', 'Fluorescence', 'Gram-Positive Bacterial Infections', 'Humans', 'Keratosis, Actinic', 'Photochemotherapy', 'Propionibacterium acnes', 'Skin Diseases', 'Skin Neoplasms'] | 21,411,414 | [['H02.403.225'], ['E01.370.350.515.277.250', 'E05.595.185.250'], ['G01.358.500.505.650.665.500', 'G01.590.540.665.500'], ['C01.150.252.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.834.450', 'C17.800.428.570'], ['E02.186.500', 'E02.319.685', 'E02.774.722'], ['B03.510.024.990.600.600', 'B03.510.460.400.... | ['Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Increased sensitivity and accumulation of estradiol in the rat oviduct during early pregnancy. | We have previously reported that a single injection of estradiol-17 beta (E2) given on day 3 of pregnancy (P3) is far more effective for accelerating oviductal transport in the rat, than treatment given on day 1 (P1). In order to quantify this change, dose-response curves were established for six different doses of E2 ... | ['Animals', 'Dose-Response Relationship, Drug', 'Estradiol', 'Female', 'Ovum Transport', 'Pregnancy', 'Pregnancy, Animal', 'Rats', 'Rats, Sprague-Dawley', 'Time Factors', 'Tissue Distribution'] | 7,647,816 | [['B01.050'], ['G07.690.773.875', 'G07.690.936.500'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['G04.198.700', 'G08.686.784.277.360'], ['G08.686.784.769'], ['G08.686.784.769.498'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['G01.910.857'], ['G03.787.917... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Scanning electron microscopy of urinary stone as a diagnostic tool. | On the basis of an extensive electron microscopic study of human urinary stones, a step by step method of stone analysis by scanning electron microscopy (SEM) morphology was developed. A preliminary blind study of 100 consecutive stones demonstrated that the method requires minimum amounts of training and is highly acc... | ['Crystallization', 'Humans', 'Methods', 'Microscopy, Electron, Scanning', 'Urinary Calculi'] | 6,523,056 | [['E05.196.300', 'G02.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['C12.777.967.500', 'C13.351.968.967.500', 'C23.300.175.850']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Hypereosinophilic syndrome in a child mosaic for a congenital triplication of the short arm of chromosome 8. | An 11-year-old boy with mental retardation, malformations, and the mosaic karyotype 47,XY,+i(8p)/46,XY presented with fever, headache and petechiae. Peripheral blood WBC was 190 x 10(9)/l; and contained > 90% mature eosinophils. Cytogenetic analysis of the eosinophils revealed no aberrations except the constitutional k... | ['Child', 'Chromosomes, Human, Pair 8', 'Coronary Thrombosis', 'Eosinophils', 'Fatal Outcome', 'Humans', 'Hypereosinophilic Syndrome', 'Karyotyping', 'Male', 'Microscopy, Electron', 'Mosaicism', 'Trisomy'] | 9,029,027 | [['M01.060.406'], ['A11.284.187.520.300.325.340', 'G05.360.162.520.300.325.340'], ['C14.280.647.250.290', 'C14.907.355.830.220', 'C14.907.585.250.290'], ['A11.118.637.415.345', 'A11.627.340.345', 'A15.145.229.637.415.345', 'A15.382.490.315.251'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.5... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Semiparametric models of time-dependent predictive values of prognostic biomarkers. | Rigorous statistical evaluation of the predictive values of novel biomarkers is critical prior to applying novel biomarkers into routine standard care. It is important to identify factors that influence the performance of a biomarker in order to determine the optimal conditions for test performance. We propose a covari... | ['Biomarkers, Tumor', 'Computer Simulation', 'Data Interpretation, Statistical', 'Diagnosis, Computer-Assisted', 'Humans', 'Male', 'Models, Statistical', 'Prevalence', 'Prognosis', 'Prostatic Neoplasms', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Time Factors'] | 19,397,579 | [['D23.101.140'], ['L01.224.160'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['E01.158', 'L01.313.500.750.100.158'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['E05... | ['Chemicals and Drugs [D]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Primary hypoadrenocorticism in a dog receiving glucocorticoid supplementation. | A 5-year-old, spayed, female husky-Labrador retriever cross was diagnosed with primary hypoadrenocorticism, an uncommon endocrine disorder caused by a deficiency of glucocorticoid and mineralocorticoid hormones. Subtle clinical signs and previous treatment with exogenous glucocorticoid drugs required an adrenocorticotr... | ['Adrenal Insufficiency', 'Adrenocorticotropic Hormone', 'Animals', 'Dog Diseases', 'Dogs', 'Female', 'Glucocorticoids'] | 10,065,324 | [['C19.053.500'], ['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['B01.050'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['D06.472.040.543', 'D27.505.69... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Application of liquid-liquid-liquid microextraction and ion-pair liquid chromatography coupled with photodiode array detection for the determination of chlorophenols in water. | A method termed as liquid-liquid-liquid microextraction was utilized to extract chlorophenols from water. The extracted chlorophenols, present in anionic form, were then separated, identified, and quantitated by ion-pair high-performance liquid chromatography with photodiode array detection (HPLC/DAD). For trace chloro... | ['Chlorophenols', 'Chromatography, Liquid', 'Reproducibility of Results', 'Spectrophotometry, Ultraviolet', 'Water Pollutants, Chemical'] | 18,420,216 | [['D02.455.426.559.389.261.190', 'D02.455.426.559.389.657.190'], ['E05.196.181.400'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['D27.888.284.903.655']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Consecutive triplet pregnancies following in-vitro fertilization and embryo transfer. Two case reports. | The number of multiple pregnancies has been increasing as a result of the relatively widespread use of drugs for induction of ovulation and assisted conception techniques. This paper details the first reported cases of triplet pregnancies occurring in consecutive IVF cycles in two patients. | ['Abortion, Spontaneous', 'Adult', 'Chorionic Gonadotropin', 'Clomiphene', 'Embryo Transfer', 'Female', 'Fertilization in Vitro', 'Follicle Stimulating Hormone', 'Humans', 'Menotropins', 'Pregnancy', 'Pregnancy, Ectopic', 'Triplets', 'Ultrasonography'] | 2,501,339 | [['C13.703.039', 'G08.686.784.769.496.125'], ['M01.060.116'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['D02.455.426.559.389.150.700.125'], ['E02.875.800.500', 'E05.820.800.500'], ['E02.875.800.750', 'E05.820.800.750'], ['D06.472.699.322.576.288', 'D06.472.699.631.525.34... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Skin and peripheral lymph node invariant NKT cells are mainly retinoic acid receptor-related orphan receptor (gamma)t+ and respond preferentially under inflammatory conditions. | Lymph nodes (LNs) have been long considered as comprising few invariant NKT (iNKT) cells, and these cells have not been studied extensively. In this study, we unravel the existence of stable rather than transitional LN-resident NK1.1(-) iNKT cell populations. We found the one resident in peripheral LNs (PLNs) to compri... | ['Animals', 'Cell Proliferation', 'Epithelial Cells', 'Galactosylceramides', 'Inflammation', 'Interleukin-17', 'Interleukin-6', 'Lymph Nodes', 'Mice', 'Mice, Knockout', 'Natural Killer T-Cells', 'Nuclear Receptor Subfamily 1, Group F, Member 3', 'Receptors, Retinoic Acid', 'Receptors, Thyroid Hormone', 'Skin'] | 19,587,013 | [['B01.050'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.436'], ['D02.065.313.250.450', 'D09.400.410.420.525.200.250.450', 'D10.390.470.675.200.250.450', 'D10.570.877.360.612.200.250.450'], ['C23.550.470'], ['D12.644.276.374.465.517', 'D12.776.467.374.465.517', 'D23.529.374.465.517'], ['D12.644.276.374.465.224', 'D1... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cold crucible levitation melting of biomedical Ti-30 wt%Ta alloy. | Recently, titanium-tantalum alloys have been studied as implant materials for dental and orthopedic surgery. However, titanium and tantalum are difficult to mix by common arc melting and induction melting, because of their high melting point and the marked difference between their densities (Ti: 1,680 degrees C, 4.5 g/... | ['Alloys', 'Biocompatible Materials', 'Chemistry, Physical', 'Copper', 'Dental Alloys', 'Electron Probe Microanalysis', 'Equipment Design', 'Hot Temperature', 'Humans', 'Materials Testing', 'Tantalum', 'Titanium', 'Water'] | 11,523,979 | [['D01.552.033', 'D25.058', 'J01.637.051.058'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['H01.181.529'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['D25.339.208', 'J01.637.051.339.208'], ['E01.370.350.515.402.250', 'E05.196.867.800.360', 'E05.595.402.250', 'E05.799.830.360'], ['E05.320'], ['... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
Biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the hepatic lobar or segmental bile ducts: imaging features in six patients. | OBJECTIVE: The purpose of this study was to evaluate the imaging features of intrahepatic biliary intraductal papillary-mucinous neoplasm manifesting only as dilatation of the lobar or segmental bile ducts without a visible mass to determine whether this type of cholangiocarcinoma can be recognized on the basis of dist... | ['Adenocarcinoma, Mucinous', 'Adenoma', 'Aged', 'Bile Duct Neoplasms', 'Diagnosis, Differential', 'Dilatation, Pathologic', 'Female', 'Humans', 'Liver Diseases', 'Male', 'Middle Aged', 'Tomography, X-Ray Computed'] | 18,716,109 | [['C04.557.470.200.025.075', 'C04.557.470.590.075'], ['C04.557.470.035'], ['M01.060.116.100'], ['C04.588.274.120.250', 'C06.130.120.120', 'C06.130.320.120', 'C06.301.120.250'], ['E01.171'], ['C23.300.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.552'], ['M01.060.116.630'], ['E01.370.350.350.810', 'E01.3... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A case study evaluating deep inspiration breath-hold and intensity-modulated radiotherapy to minimise long-term toxicity in a young patient with bulky mediastinal Hodgkin lymphoma. | Radiotherapy plays an important role in the treatment of early-stage Hodgkin lymphoma, but late toxicities such as cardiovascular disease and second malignancy are a major concern. Our aim was to evaluate the potential of deep inspiration breath-hold (DIBH) and intensity-modulated radiotherapy (IMRT) to reduce cardiac ... | ['Breath Holding', 'Hodgkin Disease', 'Humans', 'Male', 'Mediastinal Neoplasms', 'Organs at Risk', 'Radiotherapy Planning, Computer-Assisted', 'Radiotherapy, Intensity-Modulated', 'Time Factors', 'Young Adult'] | 28,188,697 | [['G09.772.705.349'], ['C04.557.386.355', 'C15.604.515.569.355', 'C20.683.515.761.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.479', 'C08.846.187.580'], ['A01.635'], ['E02.950.825', 'L01.313.500.750.100.710.600.608'], ['E02.815.635.700.700', 'L01.313.500.750.100.710.600.550.700'], ['G01.910.857... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
The Iron Chelator and Anticancer Agent Dp44mT Relieves Allergic Inflammation in Mice With Allergic Rhinitis. | Our previous study showed that an iron chelator and anticancer agent Di-2-pyridylketone-4,4-dimethyl-3-thiosemicarbazone (Dp44mT) has an antiinflammatory effect in human mast cells. However, antiinflammatory effect of Dp44mT remains unclear in animal models. In this study, we assessed whether administration of Dp44mT c... | ['Animals', 'Anti-Inflammatory Agents', 'Antineoplastic Agents', 'Chemokine CXCL2', 'Eosinophils', 'Inflammation', 'Intercellular Adhesion Molecule-1', 'Iron Chelating Agents', 'Mast Cells', 'Mice', 'Rhinitis, Allergic', 'Thiosemicarbazones'] | 29,967,928 | [['B01.050'], ['D27.505.954.158'], ['D27.505.954.248'], ['D12.644.276.374.200.120.100', 'D12.644.276.374.200.600.940', 'D12.776.467.374.200.120.100', 'D12.776.467.374.200.600.940', 'D23.125.300.120.100', 'D23.125.300.600.940', 'D23.469.200.120.100', 'D23.469.200.600.940', 'D23.529.374.200.120.100', 'D23.529.374.200.600... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Reduced allergic lung inflammation by root extracts from two species of Peucedanum through inhibition of Th2 cell activation. | ETHNOPHARMACOLOGICAL EVIDENCE: Peucedani Radix (PR), the root of Peucedanum praeruptorum Dunn (PPD) or Peucedanum decursivum (Miq.) Maxim. (PDM), has long been used in Korea to eliminate sputum, relieve cough, and reduce bronchus contraction. Furthermore, these therapeutic strategies are recognized as general and effec... | ['Allergens', 'Animals', 'Anti-Asthmatic Agents', 'Apiaceae', 'Asthma', 'Bronchoalveolar Lavage Fluid', 'CD4-Positive T-Lymphocytes', 'Cell Count', 'Cytokines', 'Eosinophilia', 'Female', 'GATA3 Transcription Factor', 'Histamine', 'Immunoglobulin E', 'Lung', 'Mice, Inbred C57BL', 'Mucus', 'Ovalbumin', 'Plant Extracts', ... | 27,965,051 | [['D23.050.063'], ['B01.050'], ['D27.505.954.796.050'], ['B01.650.940.800.575.912.250.075'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['E05.927.100.500'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['E01.370.225.500.195', 'E05.200.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Electrochemical aspects of pH electrodes. | When a pH electrode is applied intragastrically for long-term pH metry, problems may occur which are related to the specific conditions of gastric juice and to the possible difference between the temperature of buffer solutions and the body temperature. The fact that pH electrodes measure the activity of the hydrogen i... | ['Antimony', 'Body Temperature', 'Buffers', 'Calibration', 'Electrochemistry', 'Gastric Acidity Determination', 'Glass', 'Humans', 'Hydrogen-Ion Concentration', 'Microelectrodes', 'Monitoring, Physiologic'] | 2,225,514 | [['D01.268.513.124', 'D01.268.556.050', 'D01.552.544.050'], ['E01.370.600.875.374', 'G07.110'], ['D27.720.470.280'], ['E05.978.155'], ['H01.181.529.307'], ['E01.370.225.124.300', 'E01.370.372.300', 'E05.200.124.300'], ['J01.637.437'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['E07.305.250.500'], ['... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
The potentiation of ototoxicity when aminooxyacetic acid and kanamycin are co-administered. | Aminooxyacetic acid (AOAA) has been shown to confer protection against noise-induced cochlear trauma [3]. We, therefore, decided to study the possible protective effect of AOAA against kanamycin (KM) ototoxicity and found, instead, that AOAA potentiated the toxicity. To produce ototoxicity in guinea pigs, KM is usually... | ['Acetates', 'Aminooxyacetic Acid', 'Animals', 'Cochlea', 'Cochlear Microphonic Potentials', 'Drug Synergism', 'Guinea Pigs', 'Hair Cells, Auditory', 'Hearing Loss', 'Kanamycin', 'Time Factors'] | 6,490,543 | [['D02.241.081.018', 'D10.251.400.045'], ['D02.092.570.050', 'D02.241.081.018.207'], ['B01.050'], ['A09.246.300.246'], ['G07.265.216.500.370.223', 'G07.888.250.223', 'G11.561.200.500.370.223'], ['G07.690.773.968.477'], ['B01.050.150.900.649.313.992.550'], ['A08.675.650.250', 'A08.675.650.915.750.600.350', 'A08.800.950.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Possibilities for reconstruction in brachial plexus paralysis: neurotization]. | Reinnervation by nerves other than the brachial plexus are necessary if avulsion of the roots prevents neural reconstruction of the brachial plexus itself, or if functional recovery is unsatisfactory and further reconstruction is necessary for improvement. The foreign nerves mostly used today for these neurotizations a... | ['Arm', 'Brachial Plexus', 'Humans', 'Muscle, Skeletal', 'Nerve Transfer', 'Paralysis', 'Prognosis'] | 9,931,677 | [['A01.378.800.075'], ['A08.800.800.720.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633.567', 'A10.690.552.500'], ['E04.525.550'], ['C10.597.622', 'C23.888.592.636'], ['E01.789']] | ['Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Discordance and accordance between patient's and physician's assessments in rheumatoid arthritis. | OBJECTIVES: The American College of Rheumatology/European League Against Rheumatism (ACR/EULAR) remission criteria for rheumatoid arthritis (RA) are more stringent than index-based criteria, making it more difficult to achieve a patient's global assessment (PGA) than an evaluator's global assessment (EGA). We investiga... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antirheumatic Agents', 'Arthritis, Rheumatoid', 'Disability Evaluation', 'Female', 'Humans', 'Male', 'Middle Aged', 'Patients', 'Physician-Patient Relations', 'Remission Induction', 'Rheumatology', 'Severity of Illness Index', 'Young Adult'] | 24,650,255 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.329'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['E01.370.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['M01.643'], ['F01.829.401.650.675', 'N05.300.660.625'], ['E02.860'], ['H02.40... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Association between renal cysts and abdominal aortic aneurysm: A case-control study. | OBJECTIVE: To investigate the positive association between the presence of simple renal cysts (SRCs) and abdominal aortic aneurysm (AAA).METHOD: In a retrospective case-control study including subjects aged > 50 years, we evaluated the incidence of SRCs on computed tomography (CT) scan. We compared 91 consecutive patie... | ['Aged', 'Aged, 80 and over', 'Aortic Aneurysm, Abdominal', 'Case-Control Studies', 'Female', 'Humans', 'Kidney Diseases, Cystic', 'Male', 'Middle Aged', 'Retrospective Studies', 'Tomography, X-Ray Computed'] | 28,977,104 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C14.907.055.239.075', 'C14.907.109.139.075'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.403', 'C13.351.968.419.403'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Identification, typing, and insecticidal activity of Xenorhabdus isolates from entomopathogenic nematodes in United Kingdom soil and characterization of the xpt toxin loci. | Xenorhabdus strains from entomopathogenic nematodes isolated from United Kingdom soils by using the insect bait entrapment method were characterized by partial sequencing of the 16S rRNA gene, four housekeeping genes (asd, ompR, recA, and serC) and the flagellin gene (fliC). Most strains (191/197) were found to have ge... | ['Alleles', 'Animals', 'Bacterial Toxins', 'Base Sequence', 'DNA, Bacterial', 'Gene Dosage', 'Genes, Bacterial', 'Genetic Variation', 'Genomic Islands', 'Insecta', 'Insecticides', 'Nematoda', 'Phylogeny', 'RNA, Bacterial', 'RNA, Ribosomal, 16S', 'Recombination, Genetic', 'Soil Microbiology', 'Symbiosis', 'United Kingdo... | 16,957,209 | [['G05.360.340.024.340.030'], ['B01.050'], ['D23.946.123'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D13.444.308.212'], ['G05.380.350'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['G05.365'], ['G02.111.570.080.708.330.330', 'G05.360.080.708.330.330', 'G05... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
TLS/FUS-ERG fusion gene in acute lymphoblastic leukemia with t(16;21)(p11;q22) and monitoring of minimal residual disease. | This study reports a 1-year-old boy with precursor B cell acute lymphoblastic leukemia (ALL) carrying t(16;21)(p11;q22). Reverse transcriptase-polymerase chain reaction (RT-PCR) and direct sequence analysis showed TLS/FUS-ERG chimeric mRNA with a novel junctional pattern of exon 7 of TLS/FUS and exon 6 of ERG. He did n... | ['Antineoplastic Combined Chemotherapy Protocols', 'Base Sequence', 'Chromosome Mapping', 'Chromosomes, Human, Pair 16', 'Chromosomes, Human, Pair 21', 'Cytarabine', 'Etoposide', 'Exons', 'Humans', 'Idarubicin', 'Infant', 'Male', 'Neoplasm, Residual', 'Oncogene Proteins, Fusion', 'Precursor Cell Lymphoblastic Leukemia-... | 16,263,589 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.183'], ['A11.284.187.520.300.415.420', 'G05.360.162.520.300.415.420'], ['A11.284.187.520.300.505.510', 'G05.360.162.520.300.505.510'], ['D03.383.742.680.245.453', 'D13.570.065.300', 'D13.570.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Evaluation of sucromalt digestion in healthy children using breath hydrogen as a biomarker of carbohydrate malabsorption. | The measurement of hydrogen in exhaled breath is widely accepted as a non-invasive yet efficient means to evaluate carbohydrate malabsorption. Hydrogen is not normally produced by mammalian cells and its appearance in breath indicates incomplete small intestinal carbohydrate absorption with subsequent breakdown of the ... | ['Biomarkers', 'Breath Tests', 'Child', 'Dietary Carbohydrates', 'Digestion', 'Disaccharides', 'Female', 'Fructose', 'Humans', 'Hydrogen', 'Intestinal Absorption', 'Malabsorption Syndromes', 'Male', 'Sweetening Agents'] | 22,166,954 | [['D23.101'], ['E01.370.100'], ['M01.060.406'], ['D09.301', 'G07.203.300.362', 'J02.500.362'], ['G07.203.650.250', 'G10.261.190'], ['D09.698.629.305', 'D09.947.750'], ['D09.947.875.359.250', 'D09.947.875.465.354'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.406', 'D01.362.340'], ['G03.015.500.374.500', ... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Intracorporeal Traction of the Rectum with a Beaded Plastic Urinary Drainage Bag Hanger: Comparison with Conventional Laparoscopic Rectal Cancer Surgery. | BACKGROUND: Laparoscopic rectal cancer surgery with proper total mesorectal excision is a challenge for colorectal surgeons during trouble shooting. We used a beaded plastic urinary drainage bag hanger to encircle the rectum and clamp laparoscopic rectal transaction in this study.METHODS: Sixty-three patients with rect... | ['Aged', 'Digestive System Surgical Procedures', 'Female', 'Humans', 'Laparoscopy', 'Male', 'Middle Aged', 'Operative Time', 'Plastics', 'Rectal Neoplasms', 'Rectum', 'Traction', 'Treatment Outcome', 'Urinary Catheterization'] | 28,748,421 | [['M01.060.116.100'], ['E04.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.388.250.520', 'E04.502.250.520'], ['M01.060.116.630'], ['E04.614.374.500', 'N02.421.585.753.374.500'], ['D05.750.716', 'D25.720.716', 'J01.637.051.720.716'], ['C04.588.274.476.411.307.790', 'C06.301.371.411.307.790', 'C06.405.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Conversion of 1-naphthol to naphthoquinone metabolites by rat liver microsomes: demonstration by high-performance liquid chromatography with reductive electrochemical detection. | 1-Naphthol has recently been shown to be selectively toxic to short-term organ cultures of human colorectal tumor tissue. The mechanism underlying 1-naphthol's selective toxicity is as yet unknown, but may be due to the formation of naphthoquinone metabolites, which are known to be highly toxic to tumor cells. By using... | ['Animals', 'Chromatography, High Pressure Liquid', 'Cytochrome P-450 Enzyme System', 'Electrochemistry', 'In Vitro Techniques', 'Iron', 'Lipid Peroxides', 'Male', 'Microsomes, Liver', 'NADP', 'Naphthols', 'Naphthoquinones', 'Oxidation-Reduction', 'Rats', 'Rats, Inbred Strains'] | 6,517,596 | [['B01.050'], ['E05.196.181.400.300'], ['D08.244.453', 'D08.811.682.690.708.170', 'D12.776.422.220.453'], ['H01.181.529.307'], ['E05.481'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D01.248.497.158.685.750.637', 'D01.339.431.374.637', 'D01.650.550.750.600', 'D02.389.338.450', 'D10.440'], ['A11.284.83... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Deaf college students' reading comprehension and strategy use. | Two comprehension studies were conducted with 46 deaf college students. In the first, 20 deaf college students representing higher and lower reading-ability levels were tested for correctly stating the main idea of a passage, answering content questions, indicating their understanding of the words and phrases, and reco... | ['Cognition', 'Deafness', 'Humans', 'Reading', 'Students', 'Universities'] | 11,865,569 | [['F02.463.188'], ['C09.218.458.341.186', 'C10.597.751.418.341.186', 'C23.888.592.763.393.341.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.559.423.557'], ['M01.848'], ['I02.783.830', 'J03.832.830']] | ['Psychiatry and Psychology [F]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 |
Interviews of female patients with borderline personality disorder who dropped out of group psychotherapy. | Premature termination from group psychotherapy continues to be a serious problem in the treatment of patients with borderline personality disorder (BPD). Qualitative research is regarded as an important means to shed light upon the complex dynamics leading to dropout. We conducted an interview study with patients havin... | ['Affect', 'Ambulatory Care', 'Borderline Personality Disorder', 'Day Care, Medical', 'Emotions', 'Female', 'Group Processes', 'Humans', 'Interview, Psychological', 'Motivation', 'Norway', 'Patient Care Planning', 'Patient Dropouts', 'Psychotherapy, Group', 'Risk Factors'] | 17,266,430 | [['F01.470.047'], ['E02.760.106', 'N02.421.585.106'], ['F03.675.100'], ['E02.760.246', 'N02.421.585.246'], ['F01.470'], ['F01.829.316'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.669.599'], ['F01.658', 'F01.752.543.500.750'], ['Z01.542.816.374'], ['N04.590.233.624'], ['F01.100.150.750.500.610', 'F01.145.48... | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Formulation and evaluation of taste masked oral reconstitutable suspension of primaquine phosphate. | The purpose of this research was to mask the intensely bitter taste of primaquine phosphate (PRM) and to formulate suspension powder (cachets) of the taste masked drug. Taste masking was done using beta-cyclodextrin. To characterize and formulate taste masked cachets of PRM, the 1:25 M physical mixture was selected bas... | ['Administration, Oral', 'Adult', 'Drug Evaluation, Preclinical', 'Female', 'Humans', 'Male', 'Pharmaceutical Solutions', 'Primaquine', 'Solubility', 'Taste Perception', 'Young Adult'] | 18,770,047 | [['E02.319.267.100'], ['M01.060.116'], ['E05.290.750', 'E05.337.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D26.776.708', 'D27.505.954.578', 'D27.720.752'], ['D03.633.100.810.050.650'], ['G02.805'], ['F02.463.593.817'], ['M01.060.116.815']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[30 years of computer-based clinical documentation at the Heidelberg University Orthopedic Clinic. From basic documentation to medical controlling]. | An overview of the 30 years history and development of documentation and information systems in the Orthopedic University Hospital Heidelberg is presented. Since the foundation in 1967 four developmental phases can be described: first initiatives of medical doctors, establishment of a basic documentation system for sci... | ['Academic Medical Centers', 'Documentation', 'Electronic Data Processing', 'Germany', 'History, 20th Century', 'Humans', 'Medical Records Systems, Computerized', 'Orthopedics'] | 10,326,202 | [['N02.278.020'], ['L01.453.245'], ['L01.224.085'], ['Z01.542.315'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.940.968.625', 'L01.313.500.750.300.695', 'N04.452.859.564.650', 'N05.715.360.300.715.500.530', 'N06.850.520.308.940.968.625'], ['H02.403.810.494']] | ['Health Care [N]', 'Information Science [L]', 'Geographicals [Z]', 'Humanities [K]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
Bethanechol and N-acetylcysteine mimic feeding signals and reverse insulin resistance in fasted and sucrose-induced diabetic rats. | Meal-induced insulin sensitization (MIS) is explained by the HISS (hepatic insulin sensitizing substance) hypothesis. In the presence of two "feeding signals," a pulse of insulin results in the release of HISS from the liver. HISS acts selectively on skeletal muscle and doubles the response to insulin. HISS is not rele... | ['Acetylcysteine', 'Animals', 'Bethanechol', 'Biomimetic Materials', 'Diabetes Mellitus, Experimental', 'Fasting', 'Feeding Behavior', 'Glutathione', 'Insulin', 'Insulin Resistance', 'Liver', 'Male', 'Muscarinic Agonists', 'Muscle, Skeletal', 'Parasympathetic Nervous System', 'Rats', 'Rats, Sprague-Dawley', 'Sucrose'] | 21,326,345 | [['D02.886.030.230.259', 'D12.125.166.230.259'], ['B01.050'], ['D02.092.877.883.088.100', 'D02.241.081.251.133.100', 'D02.675.276.148.100'], ['J01.637.087'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['F01.145.407.400', 'G07.203.650.240.587', 'G07.203.650.353.400'], ['F01.145.113.547', 'F01.145.407', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Replicative deoxyribonucleic acid synthesis in isolated mitochondria from Saccharomyces cerevisiae. | The characteristics of a system for the in vitro synthesis of mitochondrial deoxyribonucleic acid (mtDNA) in mitochondria isolated from Saccharomyces cerevisiae are described. In this system the exclusive product of the reaction is mtDNA. Under optimal conditions the initial rate of synthesis is close to the calculated... | ['Adenosine Triphosphate', 'Centrifugation, Density Gradient', 'DNA Repair', 'DNA Replication', 'DNA, Mitochondrial', 'DNA, Single-Stranded', 'Hot Temperature', 'In Vitro Techniques', 'Kinetics', 'Magnesium', 'Mitochondria', 'Molecular Weight', 'Mutation', 'Saccharomyces cerevisiae', 'Thymine Nucleotides'] | 324,990 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['E05.181.724.336', 'E05.196.941.336'], ['G02.111.222', 'G05.219'], ['G02.111.225', 'G05.226'], ['D13.444.308.283.225'], ['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', '... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Pharmacophore modeling, 3D-QSAR and DFT studies of IWR small-molecule inhibitors of Wnt response. | In this study, a 5-point pharmacophore model was developed and the model was used to generate a predictive atom-based 3D quantitative structure activity relationship (3D-QSAR) analysis for the studied dataset of 50 compounds. The obtained 3D-QSAR model shows correlation coefficient (R(2)) of 0.87 for training set compo... | ['Drug Design', 'Humans', 'Hydrogen Bonding', 'Models, Molecular', 'Molecular Structure', 'Quantitative Structure-Activity Relationship', 'Small Molecule Libraries', 'Wnt Proteins', 'Wnt Signaling Pathway', 'beta Catenin'] | 23,914,783 | [['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.282'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['G02.111.830.500', 'G07.690.773.997.500'], ['D27.720.470.765'], ['D12.776.467.984', 'D23.529.984'], ['G02.111.820.925', 'G04.835.925'], ['D12.77... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Transvaginal cholecystectomy learning curve. | BACKGROUND: There are few surgeons in the United States, within private practice and academic centers, currently performing transvaginal cholecystectomies (TVC). The lack of exposure to TVC during residency or fellowship training, coupled with a poorly defined learning curve, further limits interested surgeons who want... | ['Adult', 'Cholecystectomy', 'Cholecystectomy, Laparoscopic', 'Female', 'Humans', 'Learning Curve', 'Operative Time'] | 25,294,548 | [['M01.060.116'], ['E04.210.120.172'], ['E04.210.120.172.140', 'E04.502.250.520.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.784.629.529.274'], ['E04.614.374.500', 'N02.421.585.753.374.500']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Topical application of a corticosteroid destabilizes the host-parasite relationship in an experimental model of the oral carrier state of Candida albicans. | Using an experimental model in the mouse we have shown that both local and central lines of defense, involving CD4+ T cells, participate in a dynamic interaction to maintain a long-term carrier state of Candida albicans in the oral cavity. We have tested the impact of a predisposing factor to oral candidiasis in the fo... | ['Administration, Topical', 'Animals', 'CD4-Positive T-Lymphocytes', 'Candidiasis, Oral', 'Carrier State', 'Dose-Response Relationship, Drug', 'Fluocinonide', 'Host-Parasite Interactions', 'Hypersensitivity, Delayed', 'Lymph Nodes', 'Lymphocyte Activation', 'Macrophage-1 Antigen', 'Male', 'Mice', 'Mice, Inbred DBA', 'M... | 7,599,602 | [['E02.319.267.120'], ['B01.050'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['C01.150.703.160.180', 'C07.465.130'], ['N06.850.520.169'], ['G07.690.773.875', 'G07.690.936.500'], ['D04.210.500.745.432.370.325', 'D04.210.500.908.394.300'], ['G16.527.200.400'], ['C2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Zinc deficiency in two infants during total parenteral alimentation for diarrhea. | Zinc deficiency was observed in two infants receiving total parenteral alimentation for chronic diarrhea. An acrodermatitis enteropathica-like rash occurred in both of the infants. Staphylococcus aureus was cultured from the rash. Treatment with zinc resulted in rapid cure of the rash and a subsidence of other signs co... | ['Acrodermatitis', 'Child, Preschool', 'Copper', 'Deficiency Diseases', 'Diarrhea, Infantile', 'Humans', 'Infant', 'Japan', 'Male', 'Parenteral Nutrition', 'Parenteral Nutrition, Total', 'Staphylococcal Infections', 'Staphylococcus aureus', 'Zinc'] | 814,805 | [['C16.131.831.066', 'C17.800.174.100', 'C17.800.804.066'], ['M01.060.406.448'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['C18.654.521.500'], ['C23.888.821.214.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['Z01.252.474.463', 'Z01.639.595'], ['E02.421.505', 'E02.642.500.505... | ['Diseases [C]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Risk perception and concern among brothers of men with prostate carcinoma. | BACKGROUND: It is important for clinicians, researchers, and others who shape public health policy to understand the demographic correlates and psychologic factors that drive health behaviors, such as screening for early detection of cancer, particularly among individuals at high risk for developing the disease.METHODS... | ['Adult', 'Aged', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Male', 'Middle Aged', 'Prostatic Neoplasms', 'Risk Assessment', 'Siblings', 'Surveys and Questionnaires'] | 15,042,690 | [['M01.060.116'], ['M01.060.116.100'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N05.715.360.750.625.700.690', 'N06.850.50... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
All-case post-marketing surveillance of 1371 patients treated with pirfenidone for idiopathic pulmonary fibrosis. | BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a chronic fibrotic lung disease with a median survival of 2-5 years and limited treatment options. In 2008, pirfenidone became the first drug to be approved for IPF treatment in Japan. The aim of this study was to assess the safety of pirfenidone for IPF treatment in a... | ['Aged', 'Disease Progression', 'Female', 'Humans', 'Idiopathic Pulmonary Fibrosis', 'Male', 'Middle Aged', 'Product Surveillance, Postmarketing', 'Prospective Studies', 'Pyridones', 'Severity of Illness Index', 'Treatment Outcome', 'Vital Capacity'] | 26,344,613 | [['M01.060.116.100'], ['C23.550.291.656'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.765.500'], ['M01.060.116.630'], ['E05.337.800'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['D03.383.725.791'], ['E05.318.308.980.438.475.456.500', 'N05.715.360.300.800.... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Molecular cloning and DNA sequence analysis of Escherichia coli topB, the gene encoding topoisomerase III. | Escherichia coli contains two type 1 topoisomerases, topoisomerase I and III. Although topoisomerase III can be purified as a potent decatenase, its role in DNA metabolism is unclear. In order to address this issue, the gene encoding topoisomerase III from E. coli has been molecularly cloned and its DNA sequence determ... | ['Amino Acid Sequence', 'Base Sequence', 'Cloning, Molecular', 'Codon', 'DNA Topoisomerases, Type I', 'DNA, Bacterial', 'Escherichia coli', 'Genes, Bacterial', 'Molecular Sequence Data', 'Restriction Mapping', 'Sequence Homology, Nucleic Acid'] | 2,553,698 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D13.444.735.544.355', 'G05.360.335.355', 'G05.360.340.024.340.137.190'], ['D08.811.399.403.483', 'D12.776.157.687.375', 'D12.776.660.720.375'], ['D13.444.308.212'], ['B03.440.450.425.325.300', 'B03... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Regulation of the c-fos promoter by the ternary complex factor Sap-1a and its coactivator CBP. | The c-fos proto-oncogene is activated by a plethora of signals via the transcription factors Sap-1a and CREB. Recently, the coactivator CBP has been demonstrated to act in concert with CREB when CREB is phosphorylated by protein kinase A. We show that CBP also binds directly to Sap-1a. While phosphorylation of Sap-1a b... | ['Animals', 'Cell Line', 'Cyclic AMP Response Element-Binding Protein', 'Cyclic AMP-Dependent Protein Kinases', 'Genes, fos', 'Phosphorylation', 'Promoter Regions, Genetic', 'Protein Binding', 'Rabbits', 'Trans-Activators'] | 8,649,857 | [['B01.050'], ['A11.251.210'], ['D12.776.260.108.184', 'D12.776.930.127.184'], ['D08.811.913.696.620.682.700.150.125', 'D12.644.360.200.125', 'D12.776.476.200.125'], ['G05.360.340.024.340.375.500.791.330'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['G02.111.570.080.689.675', 'G05.360.080.689.675', 'G05.360.340.024.34... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of threshold estimation in infants with hearing loss or normal hearing using auditory steady-state response evoked by narrow band CE-chirps and auditory brainstem response evoked by tone pips. | OBJECTIVE: The objective of this study is to compare air-conduction thresholds obtained with ASSR evoked by narrow band (NB) CE-chirps and ABR evoked by tone pips (tpABR) in infants with various degrees of hearing loss.DESIGN: Thresholds were measured at 500, 1000, 2000 and 4000 Hz. Data on each participant were collec... | ['Acoustic Stimulation', 'Audiometry', 'Auditory Perception', 'Bone Conduction', 'Case-Control Studies', 'Evoked Potentials, Auditory, Brain Stem', 'Hearing', 'Hearing Loss', 'Humans', 'Infant', 'Infant, Newborn', 'Linear Models', 'Neonatal Screening', 'Predictive Value of Tests', 'Reproducibility of Results', 'Severit... | 27,715,342 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['E01.370.382.375.060'], ['F02.463.593.071', 'G07.888.125'], ['F02.830.816.263.500', 'G07.888.500.500', 'G11.561.790.263.398'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G07.265.216.500.370.300', 'G07.888.250.300', 'G11.561.200.500.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
In vitro activities of semisynthetic pneumocandin L-733,560 against fluconazole-resistant and -susceptible Candida albicans isolates. | Lipopeptide L-733,560 is a water-soluble derivative of pneumocandin B0 that exhibits enhanced anti-Candida activity. We investigated the in vitro activity of L-733,560 compared with those of amphotericin B, flucytosine, and itraconazole, against fluconazole-resistant (n = 44) and fluconazole-susceptible (n = 46) Candid... | ['Amphotericin B', 'Anti-Bacterial Agents', 'Antifungal Agents', 'Candida albicans', 'Drug Resistance, Microbial', 'Fluconazole', 'Flucytosine', 'Itraconazole', 'Microbial Sensitivity Tests', 'Peptides'] | 8,723,483 | [['D02.540.576.500.500'], ['D27.505.954.122.085'], ['D27.505.954.122.136'], ['B01.300.107.795.095.326', 'B01.300.381.147.326', 'B01.300.930.176.326'], ['G06.225', 'G07.690.773.984.269'], ['D03.383.129.799.450'], ['D03.383.742.698.421.431'], ['D03.383.129.799.550', 'D03.383.606.530'], ['E01.370.225.875.595', 'E05.200.87... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evidence that associative interactions between synapses during the induction of long-term potentiation occur within local dendritic domains. | The present study evaluates whether the associative interactions between synapses that lead to long-term potentiation and depression (LTP and LTD) can occur between spatially segregated synapses of the medial and lateral temporodentate pathway of the rat. Coconditioning of crossed and ipsilateral pathways resulted in L... | ['Animals', 'Dendrites', 'Evoked Potentials', 'Models, Neurological', 'Rats', 'Synapses'] | 3,353,384 | [['B01.050'], ['A08.675.256', 'A11.284.180.225', 'A11.671.240'], ['G07.265.216.500', 'G11.561.200.500'], ['E05.599.395.642'], ['B01.050.150.900.649.313.992.635.505.700'], ['A08.850', 'A11.284.149.165.420.780']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of a creative art program on self-esteem, hope, perceived social support, and self-efficacy in individuals with multiple sclerosis: a pilot study. | BACKGROUND: Creative art has been found to be beneficial to some patients with chronic illness. Little is understood about how creative art can benefit individuals living with multiple sclerosis (MS).OBJECTIVES: The purpose of the pilot study was to determine if there was a difference in self-esteem, hope, perceived so... | ['Adult', 'Art Therapy', 'Female', 'Hope', 'Humans', 'Middle Aged', 'Missouri', 'Multiple Sclerosis', 'Pilot Projects', 'Self Efficacy', 'Social Perception', 'Social Support', 'Surveys and Questionnaires'] | 25,285,594 | [['M01.060.116'], ['E02.190.888.124', 'E02.760.169.063.500.100', 'E02.831.100', 'F04.754.070'], ['F01.470.572'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.107.567.875.510.515'], ['C10.114.375.500', 'C10.314.350.500', 'C20.111.258.250.500'], ['E05.318.372.750', 'E05.337.737', 'N05.715.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Bipolar sensation seeking is associated with a propensity to abuse rather than to temperamental characteristics. | OBJECTIVE: As some temperament profiles may be markers of genetic vulnerability traits, we aimed to compare sensation seeking in euthymic bipolar patients and in controls.METHODS: One hundred ninety-four patients fulfilling DSM-IV diagnostic criteria for bipolar disorders (BP), 81% of whom presented type I BP, and 95 c... | ['Adult', 'Age Distribution', 'Bipolar Disorder', 'Comorbidity', 'Exploratory Behavior', 'Female', 'Humans', 'Male', 'Middle Aged', 'Psychiatric Status Rating Scales', 'Sex Distribution', 'Substance-Related Disorders', 'Temperament'] | 11,514,131 | [['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['F03.084.500'], ['N05.715.350.225', 'N06.850.490.687'], ['F01.145.387', 'F01.658.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F04.711.513.653'], ['I01.240.800', 'N01.224.803', 'N06.850.505.400.850'], ['C25.775', ... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes: a 5-year follow-up study. | BACKGROUND: Cluster analyses have proposed different diabetes phenotypes using age, BMI, glycaemia, homoeostasis model estimates, and islet autoantibodies. We tested whether comprehensive phenotyping validates and further characterises these clusters at diagnosis and whether relevant diabetes-related complications diff... | ['Adult', 'Cluster Analysis', 'Diabetes Complications', 'Diabetes Mellitus, Type 1', 'Diabetes Mellitus, Type 2', 'Female', 'Follow-Up Studies', 'Gas Chromatography-Mass Spectrometry', 'Germany', 'Glucose Clamp Technique', 'Humans', 'Insulin Resistance', 'Male', 'Middle Aged', 'Phenotype', 'Time Factors'] | 31,345,776 | [['M01.060.116'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['C19.246.099'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['C18.452.394.750.149', 'C19.246.300'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E05.196.181.349.500', 'E05.196... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Fine-structure mapping and functional analysis of temperature-sensitive mutants in the gene encoding the herpes simplex virus type 1 immediate early protein VP175. | Herpes simplex virus (HSV)-specific proteins fall into at least three kinetic classes whose synthesis is sequentially and coordinaely regulated. Temperature-sensitive (ts) mutants of one complementation group (1-2) are defective in the transition from immediate early to early and late protein synthesis. To elucidate th... | ['Chromosome Mapping', 'Gene Expression Regulation', 'Genes', 'Genes, Viral', 'Genetic Markers', 'Mutation', 'Simplexvirus', 'Transcription, Genetic', 'Viral Proteins'] | 6,255,206 | [['E05.393.183'], ['G05.308'], ['G05.360.340.024.340'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['D23.101.387', 'G05.695.450'], ['G05.365.590'], ['B04.280.382.100.750'], ['G02.111.873', 'G05.297.700'], ['D12.776.964']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A custom speech valve retainer for the laryngectomee. | A technique is presented for the fabrication of a custom silicone speech valve retainer that is easily fabricated, may be tinted to match the skin tone, is well tolerated, noninvasive, and functions well in patients who can generate sufficient air pressure to close the valve. This device can greatly improve the quality... | ['Colloids', 'Esthetics', 'Humans', 'Laryngectomy', 'Larynx, Artificial', 'Prosthesis Design', 'Silicone Elastomers', 'Silicones'] | 3,470,512 | [['D20.280', 'D26.255.165'], ['F02.463.785.477', 'K01.752.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.580.369'], ['E07.695.450', 'E07.858.082.595'], ['E05.320.550', 'E07.695.680'], ['D05.750.900.850.900', 'D25.720.327.900', 'D25.720.900.850.900', 'J01.637.051.720.327.900', 'J01.637.051.720.900.850.900... | ['Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A qualitative investigation of the attitudes and beliefs about physical activity and post-traumatic osteoarthritis in young adults 3-10 years after an intra-articular knee injury. | OBJECTIVE: To understand the influence of the injury experience on current attitudes and beliefs about physical activity (PA) and the development of post-traumatic osteoarthritis (PTOA) in youth and young adults 3-10 years after a sport-related knee injury.DESIGN: Qualitative study.SETTING: University Sports Medical/Re... | ['Adaptation, Psychological', 'Adolescent', 'Athletes', 'Athletic Injuries', 'Attitude', 'Exercise', 'Female', 'Humans', 'Knee Injuries', 'Male', 'Osteoarthritis, Knee', 'Self Concept', 'Young Adult'] | 29,778,829 | [['F01.058'], ['M01.060.057'], ['M01.072'], ['C26.115'], ['F01.100'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.558.554'], ['C05.550.114.606.500', 'C05.799.613.500'], ['F01.752.747.792'], ['M01.060.116.815']] | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Neurobehavioral toxicity of long-term exposure to tetrachloroethylene. | One hundred and one employees of dry cleaning shops exposed to tetrachloroethylene (time weighted average 205 mg/m3) and 84 employees of departmental stores and hotels were compared from the results of a psychological examination. Age, gender, the daily consumption of alcohol and the intellectual level were taken into ... | ['Alcohol Drinking', 'Behavior', 'Discriminant Analysis', 'Hazardous Substances', 'Humans', 'Intelligence', 'Memory', 'Perception', 'Personality', 'Psychomotor Performance', 'Tetrachloroethylene'] | 2,626,148 | [['F01.145.317.269'], ['F01.145'], ['E05.318.740.350', 'N05.715.360.750.325', 'N06.850.520.830.350'], ['D27.888.426'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.543'], ['F02.463.425.540'], ['F02.463.593'], ['F01.752'], ['F02.808', 'G11.427.700', 'G11.561.660'], ['D02.455.526.439.880']] | ['Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
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