Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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[Characterization of sediment of water extract of Guizhi decoction and its effect on relevant compound (fractions) in decoction]. | In order to study the effect of sediment of water extract of Guizhi decoction on the stability, clarity and peaks area, and characterize the chemical composition of the sediments, HPLC and MS methods were established. Through comparison of the common peak areas and the turbidity value of water extract and filtrate, the... | ['Chromatography, High Pressure Liquid', 'Drugs, Chinese Herbal', 'Glycyrrhiza uralensis', 'Paeonia', 'Water'] | 29,751,710 | [['E05.196.181.400.300'], ['D20.215.784.500.350', 'D26.335'], ['B01.650.940.800.575.912.250.401.300.500'], ['B01.650.940.800.575.912.250.791'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The ontogeny and organization of the lymphoid system. | The organization of the lymphoid system reflects 2 phases in the development and function of its component lymphocytes; a primary continuous genesis of 2 lineages of lymphocytes, B and T cells, is followed by a secondary wave of cell production and differentiation dependent on antigenic stimulation. Primary B cell gene... | ['Animals', 'B-Lymphocytes', 'Cell Differentiation', 'Cell Division', 'Cell Movement', 'Humans', 'Lymphatic System', 'Lymphoid Tissue', 'Receptors, Antigen, B-Cell', 'T-Lymphocytes'] | 3,874,246 | [['B01.050'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G04.152'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G04.198', 'G07.568.500.180'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A15.382.520'], ... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Surprising alteration of antibacterial activity of 5"-modified neomycin against resistant bacteria. | A facile synthetic protocol for the production of neomycin B derivatives with various modifications at the 5'' position has been developed. The structural activity relationship (SAR) against aminoglycoside resistant bacteria equipped with various aminoglycoside-modifying enzymes (AMEs) was investigated. Enzymatic and m... | ['Anti-Bacterial Agents', 'Binding Sites', 'Crystallography, X-Ray', 'Dose-Response Relationship, Drug', 'Drug Design', 'Enterococcus', 'Enzyme Inhibitors', 'Framycetin', 'Kanamycin Kinase', 'Methicillin-Resistant Staphylococcus aureus', 'Microbial Sensitivity Tests', 'Models, Molecular', 'Molecular Structure', 'Stereo... | 19,012,394 | [['D27.505.954.122.085'], ['G02.111.570.120'], ['E05.196.309.742.225'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['B03.353.750.250.250', 'B03.510.550.250.250'], ['D27.505.519.389'], ['D09.408.051.623.300'], ['D08.811.913.696.620.475'], ['B03.300.390.400.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Defective function of GABA-containing synaptic vesicles in mice lacking the AP-3B clathrin adaptor. | AP-3 is a member of the adaptor protein (AP) complex family that regulates the vesicular transport of cargo proteins in the secretory and endocytic pathways. There are two isoforms of AP-3: the ubiquitously expressed AP-3A and the neuron-specific AP-3B. Although the physiological role of AP-3A has recently been elucida... | ['Adaptor Protein Complex 3', 'Adaptor Proteins, Vesicular Transport', 'Animals', 'Clathrin', 'DNA-Binding Proteins', 'Electrophysiology', 'GABA Plasma Membrane Transport Proteins', 'Genotype', 'Glutamates', 'Hippocampus', 'Immunoblotting', 'Immunohistochemistry', 'Membrane Transport Proteins', 'Mice', 'Mice, Inbred C5... | 15,492,041 | [['D12.776.543.990.150.300'], ['D12.776.543.990.150'], ['B01.050'], ['D12.776.543.990.200'], ['D12.776.260'], ['H01.158.344.528', 'H01.158.782.236'], ['D12.776.157.530.450.625.139', 'D12.776.157.530.562.374.750', 'D12.776.543.585.450.625.139', 'D12.776.543.585.562.374.750'], ['G05.380'], ['D12.125.067.625', 'D12.125.11... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Diffusion-weighted magnetic resonance imaging of breast lesions: first experiences at 3 T. | PURPOSE: Dynamic contrast-enhanced magnetic resonance imaging (MRI) has been established as a valuable tool for the detection of breast cancer. There is evidence suggesting that diffusion-weighted imaging (DWI) may be useful to distinguish between malignant and benign breast lesions. We seek to evaluate the ability of ... | ['Adult', 'Aged', 'Breast Neoplasms', 'Contrast Media', 'Diffusion Magnetic Resonance Imaging', 'Female', 'Gadolinium DTPA', 'Humans', 'Middle Aged', 'Observer Variation', 'Pilot Projects', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 19,188,787 | [['M01.060.116'], ['M01.060.116.100'], ['C04.588.180', 'C17.800.090.500'], ['D27.505.259.500', 'D27.720.259'], ['E01.370.350.825.500.150'], ['D02.092.782.590.401', 'D02.241.081.018.639.400', 'D02.257.141'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.354.753', 'N02.421.450.600', 'N05.715... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Mutational signatures of DNA mismatch repair deficiency in C. elegans | Throughout their lifetime, cells are subject to extrinsic and intrinsic mutational processes leaving behind characteristic signatures in the genome. DNA mismatch repair (MMR) deficiency leads to hypermutation and is found in different cancer types. Although it is possible to associate mutational signatures extracted fr... | ['Adenocarcinoma', 'Animals', 'Base Sequence', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'Colorectal Neoplasms', 'DNA Mismatch Repair', 'DNA Mutational Analysis', 'DNA Polymerase II', 'Humans', 'Mismatch Repair Endonuclease PMS2', 'MutL Protein Homolog 1', 'Mutation', 'Poly-ADP-Ribose Binding Protein... | 29,636,374 | [['C04.557.470.200.025'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.500.500.294.400.875.660.250.250'], ['D12.776.419.500'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['G02.111.22... | ['Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Propofol Does Not Reduce Pyroptosis of Enterocytes and Intestinal Epithelial Injury After Lipopolysaccharide Challenge. | BACKGROUND: To date, mechanisms of sepsis-induced intestinal epithelial injury are not well known. P2X7 receptor (P2X7R) regulates pyroptosis of lymphocytes, and propofol is usually used for sedation in septic patients.AIMS: We aimed to determine the occurrence of enterocyte pyroptosis mediated by P2X7R and to explore ... | ['Animals', 'Cell Line', 'Enterocytes', 'Hypnotics and Sedatives', 'Intestinal Mucosa', 'Lipopolysaccharides', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Propofol', 'Pyroptosis', 'Rats', 'Specific Pathogen-Free Organisms'] | 29,063,417 | [['B01.050'], ['A11.251.210'], ['A03.556.124.369.290', 'A10.615.550.444.290', 'A11.436.290'], ['D27.505.696.277.350', 'D27.505.954.427.210.350'], ['A03.556.124.369', 'A10.615.550.444'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['B01.050.150.900.649.313.992.635.505.500... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neural Correlates of Error Processing in Young People With a History of Severe Childhood Abuse: An fMRI Study. | OBJECTIVE: Childhood maltreatment is associated with various cognitive deficits, including inhibitory deficits and hypersensitivity to negative feedback. The authors used a stop-signal task to investigate the association between severe childhood abuse and inhibitory and error processing brain activation in medication-n... | ['Adolescent', 'Adult Survivors of Child Abuse', 'Brain', 'Case-Control Studies', 'Child Abuse', 'Female', 'Functional Neuroimaging', 'Humans', 'Inhibition, Psychological', 'Magnetic Resonance Imaging', 'Male', 'Psychomotor Performance', 'Reaction Time', 'Young Adult'] | 25,882,324 | [['M01.060.057'], ['M01.135.500', 'M01.860.300.500'], ['A08.186.211'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['I01.198.240.856.350.250', 'I01.880.735.900.350.250'], ['E01.370.350.578.875', 'E01.370.376.537.625', 'E05.629.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Effect of a tele-training programme on radiographers in the interpretation of CT colonography. | OBJECTIVE: To assess the performance of radiographers in CT colonography (CTC) after a tele-training programme, supervised by 2 experienced radiologists.MATERIALS AND METHODS: Five radiographers underwent training in CTC using a tele-training programme mainly based on the interpretation of 75 training cases performed i... | ['Colonography, Computed Tomographic', 'Computer-Assisted Instruction', 'Denmark', 'Education, Continuing', 'Education, Distance', 'Educational Measurement', 'Professional Competence', 'Radiology', 'Telemedicine'] | 21,397,422 | [['E01.370.350.350.810.180', 'E01.370.350.600.350.700.810.180', 'E01.370.350.700.700.810.180', 'E01.370.350.700.810.810.180', 'E01.370.372.230'], ['I02.903.771.500.208'], ['Z01.542.816.124'], ['I02.358.212'], ['I02.195'], ['I02.399'], ['I02.399.630'], ['H02.403.740'], ['H02.403.840', 'L01.178.847.652', 'N04.590.374.800... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
Contribution of subcortical motor pathways to the execution of ballistic movements. | Preparation for a voluntary ballistic movement in the context of a simple reaction time task (SRT) involves enhancement of excitability in subcortical motor tracts. However, little is known about the characteristics of that preparation, how long the excitability enhancement takes place, and whether it is present not on... | ['Acoustic Stimulation', 'Choice Behavior', 'Efferent Pathways', 'Electromyography', 'Functional Laterality', 'Hand', 'Humans', 'Motor Cortex', 'Movement', 'Psychomotor Performance', 'Reaction Time', 'Reflex, Startle', 'Time Factors'] | 16,106,656 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['F02.463.785.373.346'], ['A08.612.380'], ['E01.370.405.255', 'E01.370.530.255'], ['F02.830.297.425', 'G11.561.225.425'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.186.211.200.885.287.500.270.548', 'A08.186.211.200.885.287.500.814.624'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A multicenter, open-label study of repeat courses of intramuscular alefacept in combination with other psoriasis therapies in patients with chronic plaque psoriasis. | OBJECTIVE: To evaluate the safety and efficacy of multiple courses of alefacept in combination with traditional psoriasis therapy for the treatment of chronic plaque psoriasis (CPP).METHODS: Patients with CPP requiring systemic therapy were eligible for this study. Patients received up to three courses of intramuscular... | ['Adult', 'Alefacept', 'CD4 Lymphocyte Count', 'Cyclosporine', 'Dermatologic Agents', 'Drug Administration Routes', 'Drug Administration Schedule', 'Drug Therapy, Combination', 'Female', 'Glucocorticoids', 'Humans', 'Immunologic Factors', 'Immunosuppressive Agents', 'Infections', 'Lymphopenia', 'Male', 'Methotrexate', ... | 18,569,270 | [['M01.060.116'], ['D12.776.124.486.485.114.619.393.131', 'D12.776.124.790.651.114.619.393.131', 'D12.776.377.715.548.114.619.393.131', 'D12.776.395.550.034.500', 'D12.776.543.550.158.500', 'D12.776.828.300.100'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.15... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Development and Performance of an Algorithm to Estimate the Child-Turcotte-Pugh Score From a National Electronic Healthcare Database. | BACKGROUND & METHODS: The Child-Turcotte-Pugh (CTP) score is a widely used and validated predictor of long-term survival in cirrhosis. The CTP score is a composite of 5 subscores, 3 based on objective clinical laboratory values and 2 subjective variables quantifying the severity of ascites and hepatic encephalopathy. T... | ['Algorithms', 'Ascites', 'Cohort Studies', 'Databases, Factual', 'Electronic Health Records', 'Female', 'Hepatic Encephalopathy', 'Humans', 'Liver Cirrhosis', 'Male', 'Middle Aged', 'Prognosis', 'Severity of Illness Index', 'Survival', 'United States'] | 26,188,137 | [['G17.035', 'L01.224.050'], ['C23.550.081'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E05.318.308.940.968.625.500', 'N04.452.859.564.650.125', 'N05.715.360.300.715.500.530.250', 'N06.850.520.308.940.968.625.250'], ['C06.552.308... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
[Clinical outcomes of trimetazidine in patients with acute ST segment elevation myocardial infarction without ST segment resolution after primary percutaneous coronary intervention]. | OBJECTIVE: To evaluate prospectively the clinical outcomes of trimetazidine (TMZ) in patients with acute ST segment elevation myocardial infarction (STEMI) without ST segment resolution (STR) after primary percutaneous coronary intervention (PPCI).METHODS: From August 2005 to October 2007, 138 acute STEMI patients with... | ['Aged', 'Angioplasty, Balloon, Coronary', 'Electrocardiography', 'Humans', 'Middle Aged', 'Myocardial Infarction', 'Prospective Studies', 'Treatment Outcome', 'Trimetazidine', 'Vasodilator Agents'] | 19,671,333 | [['M01.060.116.100'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of thyrotropin on thyroid chromatin. Enhanced sensitivity to micrococcal nuclease and increased nuclear protein phosphorylation. | Thyroid slices were incubated with or without TSH for 2 or 5 h. Nuclei were then prepared, subjected to mild digestion with micrococcal nuclease, and centrifuged at 1200 X g. The amount of DNA in 1200 X g supernatants was increased by TSH at 5 h, but not at 2 h. In parallel studies, thyroid slices were incubated with 3... | ['Animals', 'Cattle', 'Chromatin', 'DNA', 'Micrococcal Nuclease', 'Nucleoproteins', 'Phosphoproteins', 'Phosphorylation', 'Thyroid Gland', 'Thyrotropin'] | 6,860,668 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['D13.444.308'], ['D08.811.277.352.335.350.500', 'D08.811.277.352.355.325.500', 'D08.811.277.352.355.350.500', 'D08.811.277.352.700.350.500'], ['D12.776.664'], ['D12.776.744'], ['G02.111... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Diffuse recidivant alveolar hemorrhage in a patient with hepatitis C virus-related mixed cryoglobulinemia. | A case of diffuse and recidivant alveolar hemorrhage is presented in a patient with hepatitis C virus-related type II mixed cryoglobulinemia with membranoproliferative glomerulonephritis. The patient was a 48-year-old white woman who suffered several outbreaks of pulmonary hemorrhage refractory to treatment with steroi... | ['Cryoglobulinemia', 'Fatal Outcome', 'Female', 'Glomerulonephritis, Membranoproliferative', 'Hemorrhage', 'Hepatitis C', 'Humans', 'Lung Diseases', 'Middle Aged', 'Pulmonary Alveoli'] | 10,229,169 | [['C14.907.454.140', 'C15.378.147.780.243', 'C15.378.463.515.140', 'C20.683.780.250'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N06.850.520.308.985.550.325'], ['C12.777.419.570.363.615', 'C13.351.968.419.570.363.615', 'C20.425'], ['C23.550.414'], ['C01.221.250.750', 'C01.925.44... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Socio-economic and school factors of psychological and physical health in Siberian schoolchildren. | Cultural influences on psychological and physical health were examined in a sample of Russian schoolchildren in Novosibirsk. To evaluate the children's behaviour the translated short form of the Child Behaviour Checklist was given out to mothers. A School Adjustment Scale and the Rutter Teacher Questionnaire were compl... | ['Adolescent', 'Child', 'Child Behavior', 'Female', 'Health Status Indicators', 'Humans', 'Male', 'Mental Health', 'Siberia', 'Social Class'] | 11,507,981 | [['M01.060.057'], ['M01.060.406'], ['F01.145.179'], ['E05.318.308.980.438.475', 'N05.715.360.300.800.438.375', 'N06.850.520.308.980.438.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.418', 'N01.400.500'], ['Z01.252.122.500.500'], ['I01.880.853.996.755', 'N01.824.782']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
A Carbon Nanotube Optical Reporter Maps Endolysosomal Lipid Flux. | Lipid accumulation within the lumen of endolysosomal vesicles is observed in various pathologies including atherosclerosis, liver disease, neurological disorders, lysosomal storage disorders, and cancer. Current methods cannot measure lipid flux specifically within the lysosomal lumen of live cells. We developed an opt... | ['Atherosclerosis', 'DNA, Single-Stranded', 'Endosomes', 'Humans', 'Lipids', 'Luminescent Measurements', 'Lysosomes', 'Macrophages', 'Monocytes', 'Nanotubes, Carbon', 'Niemann-Pick Disease, Type C', 'Optics and Photonics', 'Single-Cell Analysis', 'Transport Vesicles'] | 28,898,055 | [['C14.907.137.126.307'], ['D13.444.308.497', 'G02.111.570.820.486.437', 'G05.360.580.437'], ['A11.284.430.214.190.875.190.880.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D10'], ['E05.196.712.516'], ['A11.284.430.214.190.875.190.550'], ['A11.329.372', 'A11.627.482', 'A11.733.397', 'A15.382.670.522', 'A15.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
An attempt at topical DNCB immunomodulation in advanced malignant melanoma. | Nineteen patients with malignant melanoma metastatic to the skin, subcutaneous tissue or lymph nodes were treated with DNCB applied to the lesion. None of the patients was amenable to any other form of treatment. During the 20-month follow-up, complete remission occurred in 3 patients and partial remission in 3 patient... | ['Administration, Topical', 'Adult', 'Aged', 'Dinitrochlorobenzene', 'Female', 'Humans', 'Lymphatic Metastasis', 'Melanoma', 'Middle Aged', 'Skin Neoplasms'] | 3,217,986 | [['E02.319.267.120'], ['M01.060.116'], ['M01.060.116.100'], ['D02.455.426.559.389.261.250', 'D02.455.426.559.389.565.250', 'D02.455.526.439.202.200', 'D02.640.529.240.250', 'D23.050.550.480.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ['C04.557.465.625.650.510', 'C... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Risk assessment of premature drug release during wet granulation of ordered mesoporous silica loaded with poorly soluble compounds itraconazole, fenofibrate, naproxen, and ibuprofen. | In this study, the potential of wet granulation of ordered mesoporous silica (OMS) material was evaluated to assess the risk of premature drug release during processing and to improve the bulk powder flow properties and compactibility for the development of an immediate release oral dosage form. The poorly water solubl... | ['Calorimetry, Differential Scanning', 'Carboxymethylcellulose Sodium', 'Excipients', 'Fenofibrate', 'Ibuprofen', 'Itraconazole', 'Naproxen', 'Particle Size', 'Porosity', 'Powders', 'Risk Assessment', 'Silicon Dioxide', 'Solubility', 'Temperature'] | 22,306,694 | [['E05.196.131.310', 'E05.196.370.310'], ['D09.698.365.180.663.329'], ['D26.650.700.419', 'D27.720.744.770.419'], ['D02.241.081.114.968.500.625', 'D02.355.726.305.625', 'D02.455.426.559.389.134.750', 'D02.455.426.559.389.657.654.305.625', 'D02.522.223.750'], ['D02.241.223.701.430'], ['D03.383.129.799.550', 'D03.383.606... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Transactivation of lifeguard (LFG) by Akt-/LEF-1 pathway in MCF-7 and MDA-MB 231 human breast cancer cells. | Lifeguard (LFG) has been identified as a molecule that uniquely inhibits death mediated by Fas. The molecular function of human LFG and its regulation in carcinogenesis is uncertain. In our study, we investigated the potential regulation of LFG expression by Akt/LEF-1 pathway. The Glycogen synthase kinase-3 (GSK3) can ... | ['Apoptosis', 'Apoptosis Regulatory Proteins', 'Breast Neoplasms', 'Cell Line, Tumor', 'Female', 'Gene Expression Regulation, Neoplastic', 'Glycogen Synthase Kinase 3', 'Glycogen Synthase Kinase 3 beta', 'Humans', 'Lymphoid Enhancer-Binding Factor 1', 'Membrane Proteins', 'Promoter Regions, Genetic', 'Proto-Oncogene Pr... | 20,336,373 | [['G04.146.954.035'], ['D12.644.360.075', 'D12.776.476.075'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['G05.308.370'], ['D05.500.117.875', 'D08.811.913.696.620.682.700.429.500', 'D08.811.913.696.620.682.700.646.625', 'D12.644.360.300.500', 'D12.776.476.081.875', 'D12.776.476.300.500'... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Crosstalk between pathways enhances the controllability of signalling networks. | The control of complex networks is one of the most challenging problems in the fields of biology and engineering. In this study, the authors explored the controllability and control energy of several signalling networks, which consisted of many interconnected pathways, including networks with a bow-tie architecture. On... | ['Algorithms', 'Models, Biological', 'Signal Transduction', 'Systems Biology'] | 26,816,393 | [['G17.035', 'L01.224.050'], ['E05.599.395'], ['G02.111.820', 'G04.835'], ['H01.158.273.180.800']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Is there an increased risk for renal tumors during long-term treatment with lithium?]. | Lithium salts are the recommended first-line treatment (gold standard) in national and international treatment guidelines for acute and maintenance treatment of affective disorders, such as bipolar disorders. Lithium has also been shown to have a unique protective effect against suicide in patients suffering from affec... | ['Bipolar Disorder', 'Comorbidity', 'Europe', 'Evidence-Based Medicine', 'Humans', 'Kidney Neoplasms', 'Lithium Compounds', 'Risk Factors', 'Treatment Outcome'] | 26,341,836 | [['F03.084.500'], ['N05.715.350.225', 'N06.850.490.687'], ['Z01.542'], ['H02.249.750', 'H02.403.200.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.945.947.535', 'C12.758.820.750', 'C12.777.419.473', 'C13.351.937.820.535', 'C13.351.968.419.473'], ['D01.510'], ['E05.318.740.600.800.725', 'N05.715.350.2... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Characterization of human immune responses to the cytosolic superoxide dismutase and glutathione S-transferase from Onchocerca volvulus. | In onchocerciasis patients and in O. volvulus-exposed individuals without signs of onchocericiasis, T- and B-cell responses to two recombinantly expressed O. volvulus enzymes were analysed and compared to responses to total protein extract of adult parasites. The cytosolic enzymes Cu/Zn superoxide dismutase 1 (OvSOD1) ... | ['Adolescent', 'Adult', 'Animals', 'Antibodies, Helminth', 'Antigens, Helminth', 'B-Lymphocytes', 'Child', 'Cytosol', 'Female', 'Glutathione Transferase', 'Humans', 'Immunoglobulin G', 'Interferon-gamma', 'Interleukin-10', 'Interleukin-5', 'Leukocytes, Mononuclear', 'Male', 'Middle Aged', 'Onchocerca volvulus', 'Onchoc... | 9,294,549 | [['M01.060.057'], ['M01.060.116'], ['B01.050'], ['D12.776.124.486.485.114.185', 'D12.776.124.790.651.114.185', 'D12.776.377.715.548.114.185'], ['D23.050.223'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['M01.060.406'], ['A11.284.430.214.200'... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Phage-Antibiotic Synergy (PAS): beta-lactam and quinolone antibiotics stimulate virulent phage growth. | Although the multiplication of bacteriophages (phages) has a substantial impact on the biosphere, comparatively little is known about how the external environment affects phage production. Here we report that sub-lethal concentrations of certain antibiotics can substantially stimulate the host bacterial cell's producti... | ['Anti-Bacterial Agents', 'Bacteriophages', 'DNA, Bacterial', 'Escherichia coli', 'Quinolones', 'Viral Proteins', 'beta-Lactams'] | 17,726,529 | [['D27.505.954.122.085'], ['B04.123'], ['D13.444.308.212'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D03.633.100.810.835'], ['D12.776.964'], ['D02.065.589.099', 'D02.886.108', 'D03.633.100.300']] | ['Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
EpiFloripa Health Survey: the methodological and operational aspects behind the scenes. | The present study aims at describing the sampling plan, operational aspects and strategies used to optimize the field work of a cross-sectional, population-based study conducted in a southern capital of Brazil. For this purpose, the sample design, data collection instrument, selection of interviewers, pilot study, data... | ['Adult', 'Brazil', 'Cross-Sectional Studies', 'Female', 'Health Surveys', 'Humans', 'Male', 'Middle Aged', 'Pilot Projects', 'Surveys and Questionnaires', 'Young Adult'] | 24,896,789 | [['M01.060.116'], ['Z01.107.757.176'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05.318.308.980.438', 'N05.715.360.300.800.438', 'N06.850.520.308.980.438'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.7... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Effects of etanercept versus sulfasalazine in early axial spondyloarthritis on active inflammatory lesions as detected by whole-body MRI (ESTHER): a 48-week randomised controlled trial. | PURPOSE: To evaluate the potential of etanercept versus sulfasalazine to reduce active inflammatory lesions on whole-body MRI in active axial spondyloarthritis with a symptom duration of less than 5 years.METHODS: Patients were randomly assigned to etanercept (n=40) or sulfasalazine (n=36) treatment over 48 weeks. All ... | ['Adolescent', 'Adult', 'Antirheumatic Agents', 'Epidemiologic Methods', 'Etanercept', 'Female', 'Humans', 'Immunoglobulin G', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Receptors, Tumor Necrosis Factor', 'Sacroiliac Joint', 'Spine', 'Spondylarthritis', 'Sulfasalazine', 'Treatment Outcome', 'Tumor Necrosis F... | 21,372,193 | [['M01.060.057'], ['M01.060.116'], ['D27.505.954.329'], ['E05.318', 'N06.850.520'], ['D12.644.541.500.697.624', 'D12.776.124.486.485.538.500.624', 'D12.776.124.486.485.680.697.624', 'D12.776.124.790.651.538.500.624', 'D12.776.124.790.651.680.660.624', 'D12.776.377.715.548.538.500.624', 'D12.776.377.715.548.680.660.624'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Anterior encephalocele. | Eighteen cases of anterior encephalocele treated at the University of Malaya Hospital between 1970 and 1980 are discussed, and the literature concerning this defect is reviewed. A detailed analysis of the microscopic abnormalities present in the surgical specimens is included, along with the relevant radiographic and d... | ['Adult', 'Encephalocele', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Malaysia', 'Male', 'Methods'] | 7,452,336 | [['M01.060.116'], ['C10.500.680.488', 'C16.131.666.680.488', 'C23.300.707.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['Z01.252.145.487'], ['E05.581']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Multiple myeloma in central Norway 1981-1982: a randomized clinical trial of 5-drug combination therapy versus standard therapy. | 67 previously untreated patients with multiple myeloma were entered on a randomized clinical trial to determine whether the use of combination chemotherapy including vincristine, carmustine, alkylating agents, and prednisone was more effective than conventional therapy with melphalan and prednisone. The treatment group... | ['Antineoplastic Combined Chemotherapy Protocols', 'Carmustine', 'Clinical Trials as Topic', 'Cyclophosphamide', 'Humans', 'Melphalan', 'Multiple Myeloma', 'Prednisone', 'Random Allocation', 'Vincristine'] | 3,538,367 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['D02.065.950.594.247', 'D02.654.692.247'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['D02.455.526.728.650.730.243', 'D02.705.672.500.243'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.526.728.650.594', 'D12... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Cellular retinoic acid-binding protein type II is expressed in adult human osteoblasts and in adult liver. | In this study we have used a reverse transcription polymerase chain reaction (RT-PCR) to demonstrate that adult primary human osteoblasts and SaOS-2, a human osteosarcoma-derived cell line with osteoblastic properties, express cellular retinol-binding protein I (CRBP I), cellular retinoic acid-binding protein II (CRABP... | ['Adult', 'Base Sequence', 'Carrier Proteins', 'Cells, Cultured', 'Humans', 'Liver', 'Molecular Sequence Data', 'Oligodeoxyribonucleotides', 'Osteoblasts', 'Osteosarcoma', 'Polymerase Chain Reaction', 'RNA', 'Receptors, Retinoic Acid', 'Tretinoin', 'Tumor Cells, Cultured'] | 1,282,801 | [['M01.060.116'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D12.776.157'], ['A11.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['L01.453.245.667'], ['D13.695.578.424.450'], ['A11.329.629'], ['C04.557.450.565.575.650', 'C04.557.450.795.620'], ['E05.393.620.500'], ['D13.444.735']... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
The influence of film processing temperature and time on mammographic image quality. | High image quality and low radiation levels are essential in mammography. This study investigates the effect of changes in processor temperatures and developing times on sensitometric findings. These findings were matched with the changes in the image quality during similar changes in the developing parameters. Tempera... | ['Female', 'Humans', 'Mammography', 'Models, Structural', 'Technology, Radiologic', 'Temperature', 'Time Factors', 'X-Ray Film'] | 7,719,681 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.700.500'], ['J01.897.280.500.545', 'L01.178.820.090.545'], ['E05.920', 'H02.010.850', 'J01.897.891'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['G01.910.857'], ['E07.960']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 |
Effect of Scrophularia buergeriana extract on the degranulation of mast cells and ear swelling induced by dinitrofluorobenzene in mice. | Scrophularia buergeriana Miquel (Scrophulariaceae, SB) is a biennial plant native to Korea, northern China, and Japan that plays an important role in traditional medicine. The dried root of SB has long been used in oriental medicine for treatment of fever, swelling, constipation, pharyngitis, neuritis, and laryngitis. ... | ['Animals', 'Anti-Allergic Agents', 'Cell Degranulation', 'Cell Line, Tumor', 'Dermatitis, Contact', 'Dinitrofluorobenzene', 'Ear', 'Edema', 'Histamine Release', 'Inflammation', 'Interleukin-4', 'Mast Cells', 'Medicine, East Asian Traditional', 'Mice', 'Plant Extracts', 'Scrophularia', 'Tumor Necrosis Factor-alpha', 'b... | 21,318,391 | [['B01.050'], ['D27.505.954.016'], ['G04.468.160'], ['A11.251.210.190', 'A11.251.860.180'], ['C17.800.174.255', 'C17.800.815.255'], ['D02.455.426.559.389.565.280', 'D02.640.529.240.280'], ['A01.456.313', 'A09.246'], ['C23.888.277'], ['G12.350'], ['C23.550.470'], ['D12.644.276.374.465.186', 'D12.776.467.374.465.178', 'D... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
[Occurrence of argyrophilic grains in multiple system atrophy: histopathological examination of 26 autopsy cases]. | Argyrophilic grain disease (AGD) is a progressive disorder producing dementia in elderly individuals characterized by the presence of numerous AGs in the limbic system. However, the occurrence of AGs has been reported in other neurodegenerative conditions including Alzheimer's disease, Pick's disease, progressive supra... | ['Aged', 'Brain', 'Female', 'Humans', 'Immunohistochemistry', 'Male', 'Middle Aged', 'Multiple System Atrophy', 'Phosphorylation', 'tau Proteins'] | 10,396,750 | [['M01.060.116.100'], ['A08.186.211'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
A re-assessment of the effects of intracortical delivery of inosine on transmidline growth of corticospinal tract axons after unilateral lesions of the medullary pyramid. | This study was undertaken as part of the NIH "Facilities of Research Excellence-Spinal Cord Injury", which supports independent replication of published studies. Here, we repeat an experiment reporting that intracortical delivery of inosine promoted trans-midline growth of corticospinal tract (CST) axons in the spinal ... | ['Animals', 'Axons', 'Cerebral Cortex', 'Drug Delivery Systems', 'Drug Evaluation, Preclinical', 'Inosine', 'Male', 'Medulla Oblongata', 'Nerve Regeneration', 'Pyramidal Tracts', 'Rats', 'Rats, Sprague-Dawley'] | 21,946,267 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['A08.186.211.200.885.287.500'], ['E02.319.300'], ['E05.290.750', 'E05.337.550'], ['D03.633.100.759.590.616', 'D13.570.583.616', 'D13.570.800.573'], ['A08.186.211.132.810.591.500'], ['G11.561.585', 'G16.762.611'], ['A08.186.854.300'... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Occupation and suicide among males in the US Armed Forces. | During the period 1980 to 1992, 95% of the 3178 military suicide victims were men and 92% enlisted; of the men, 71% were aged 20 to 34, 82% were white, and 61% used a firearm. Information extracted from the Report of Casualty of the Worldwide Casualty System maintained by the Department of Defense was used to describe ... | ['Adolescent', 'Adult', 'Cause of Death', 'Firearms', 'Humans', 'Male', 'Middle Aged', 'Military Personnel', 'Occupations', 'Risk Factors', 'Social Control, Formal', 'Suicide', 'United States'] | 8,680,630 | [['M01.060.057'], ['M01.060.116'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['J01.637.870.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['M01.526.625'], ['N01.824.547'], ['E05.318.740.600.800.725', 'N05.715.350.200.7... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Vasopressin deficiency and pressor hypersensitivity in hemodynamically unstable organ donors. | BACKGROUND: Solid organ donors often develop hypotension due to vasodilation, and recently we observed that a variety of vasodilatory states are characterized by vasopressin deficiency and hypersensitivity. Thus, we investigated the prevalence of vasopressin deficiency in hypotensive solid organ donors without clinical... | ['Adolescent', 'Adult', 'Baroreflex', 'Blood Pressure', 'Female', 'Hemodynamics', 'Humans', 'Male', 'Middle Aged', 'Osmolar Concentration', 'Tissue Donors', 'Vasopressins'] | 10,567,311 | [['M01.060.057'], ['M01.060.116'], ['G09.330.380.057', 'G11.561.731.063'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G02.640'], ['M01.898'], ['D06.472.699.631.692.781', 'D12.644.400.900', 'D12.644.456.925', 'D12.644.548.691.692.7... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Conformational study of eight-membered diazocine turn mimics by two-dimensional NMR spectroscopy. | The eight-membered ring conformations of two diazocine turn mimics, methyl-[2,5-dioxo-3-(S)-(3-omega-tosyl-guanidino-propyl)-4-methyl-octahy dro- 1,4-diazocin-1-yl]acetate (I) and methyl-[2,5-dioxo-3-(S)-(3-omega-tosyl-guanidino-propyl)-octahydro-1,4- diazocin-1-yl]acetate (II), were determined using torsion angle cons... | ['Azocines', 'Magnetic Resonance Spectroscopy', 'Models, Molecular', 'Molecular Structure', 'Oligopeptides', 'Protein Conformation'] | 7,957,914 | [['D03.383.113'], ['E05.196.867.519'], ['E05.599.595'], ['G02.111.570', 'G02.466'], ['D12.644.456'], ['G02.111.570.820.709']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
THM, HAA and CNCl formation from UV irradiation and chlor(am)ination of selected organic waters. | The formation of disinfection by-products (DBPs), including chloroform, dichloroacetic acid (DCAA), trichloroacetic acid (TCAA), and cyanogen chloride (CNCl) after sequential exposure of four organic waters to UV irradiation via either low- or medium-pressure lamps and free chlorine (or preformed monochloramine) under ... | ['Acetates', 'Chlorine', 'Cyanides', 'Environmental Monitoring', 'Hong Kong', 'Humic Substances', 'Rivers', 'Trihalomethanes', 'Ultraviolet Rays', 'Water Pollutants, Chemical'] | 16,678,880 | [['D02.241.081.018', 'D10.251.400.045'], ['D01.268.380.150', 'D01.362.225'], ['D01.248.497.158.291', 'D01.625.400.100'], ['N06.850.460.350.080', 'N06.850.780.375'], ['Z01.252.474.164.450'], ['D02.241.444', 'D02.455.426.559.389.657.377', 'D20.721.500'], ['G01.311.750', 'G16.500.275.280.650', 'N06.230.232.650'], ['D02.45... | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Drug screening in newborns and mothers using meconium samples, paired urine samples, and interviews. | We evaluated the prevalence of illicit substance abuse by comparing drug screening results derived from meconium, urine pairs, and maternal interview. Mother/infant pairs (580) were entered into this blinded, prospective study. Prevalence of illicit substance abuse was 3.4%. The lack of prenatal care correlated with th... | ['Cocaine', 'Female', 'Humans', 'Infant, Newborn', 'Interviews as Topic', 'Male', 'Marijuana Abuse', 'Meconium', 'Neonatal Screening', 'Pregnancy', 'Pregnancy Outcome', 'Prevalence', 'Prospective Studies', 'Substance Abuse Detection', 'Substance-Related Disorders', 'Urinalysis'] | 7,666,268 | [['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['C25.775.635', 'F03.900.635'], ['A12.459.529', 'A16.378.529'], ['E01.370... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Regulation of B lymphocytes in health and disease. Meeting review. | Signal transduction by the B cell receptor (BCR) is an absolute requirement for the selection and development of B lymphocytes at multiple checkpoints. Binding to antigen via the BCR is complemented by a co-stimulus delivered through accessory and co-stimulatory cell surface molecules that regulate the signalling thres... | ['Animals', 'Antibody Affinity', 'B-Lymphocytes', 'Cell Differentiation', 'Immune System', 'Mice', 'Mutation', 'Receptors, Antigen, B-Cell', 'Receptors, IgG', 'Signal Transduction'] | 12,493,640 | [['B01.050'], ['G12.040', 'G12.122.125'], ['A11.063.438', 'A11.118.637.555.567.562', 'A15.145.229.637.555.567.562', 'A15.382.032.438', 'A15.382.490.555.567.562'], ['G04.152'], ['A15.382'], ['B01.050.150.900.649.313.992.635.505.500'], ['G05.365.590'], ['D12.776.124.790.651.950', 'D12.776.377.715.548.950', 'D12.776.543.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A survey of first-responder firefighters' attitudes, opinions, and concerns about their automated external defibrillator program. | OBJECTIVE: To identify barriers to first-responder automated external defibrillator (AED) use by determining firefighter attitudes, opinions, and concerns about their AED program.METHODS: An anonymous survey was mailed to all firefighters in a municipal department that had had first-responder defibrillation for more th... | ['Attitude of Health Personnel', 'Defibrillators', 'Emergency Medical Technicians', 'Heart Arrest', 'Humans', 'New York', 'Surveys and Questionnaires'] | 12,540,155 | [['F01.100.050', 'N05.300.100'], ['E07.305.250.159'], ['M01.526.373.250', 'M01.526.485.067.150', 'N02.360.067.150'], ['C14.280.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.075.437', 'Z01.107.567.875.350.530', 'Z01.107.567.875.500.530'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.52... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Enrolled nurse skill extension: metropolitan myth or rural reality? | OBJECTIVE: The objective of this study was to examine whether the position of 'after hours clinical support enrolled nurse' is embracing clinical skill extension in the acute surgical area.DESIGN: Experienced enrolled nurses employed in a supernumerary capacity documented all activities with which they were engaged ove... | ['Adult', 'Australia', 'Clinical Competence', 'Female', 'Humans', 'Nurses', 'Rural Health Services', 'Urban Health Services', 'Workforce'] | 17,518,164 | [['M01.060.116'], ['Z01.639.100', 'Z01.678.100.373'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.650', 'N02.360.650'], ['N02.421.816'], ['N02.421.914'], ['N04.452.525']] | ['Named Groups [M]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Molecular movement in the Arabidopsis thaliana female gametophyte. | KEY MESSAGE: Size limits on molecular movement among female gametes. Cellular decisions can be influenced by information communicated from neighboring cells. Communication can occur via signaling or through the direct transfer of molecules. Movement of RNAs and proteins has frequently been observed among symplastically... | ['Arabidopsis', 'Cell Communication', 'Endosperm', 'Fluorescent Dyes', 'Microinjections', 'Ovule', 'Particle Size', 'Pollination', 'RNA', 'Seeds'] | 28,695,277 | [['B01.650.940.800.575.912.250.157.100'], ['G04.085'], ['A18.024.500.750.666'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['E02.319.267.530.690', 'E05.591.570'], ['A18.024.249.500.249.249'], ['G02.712'], ['G08.686.784.743', 'G15.776'], ['D13.444.735'], ['A18.024.500.750', 'G07.203.300.775', 'J02.500.775']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A carrier state is established in Pseudomonas aeruginosa by phage LeviOr01, a newly isolated ssRNA levivirus. | ssRNA bacteriophages are very abundant but poorly studied, particularly in relation to their effect on bacterial evolution. We isolated a new Pseudomonas aeruginosa levivirus, vB_PaeL_PcyII-10_LeviOr01, from hospital waste water. Its genome comprises 3669 nucleotides and encodes four putative proteins. Following bacter... | ['Genome, Viral', 'Host-Parasite Interactions', 'Levivirus', 'Pseudomonas Phages', 'Pseudomonas aeruginosa', 'RNA, Viral', 'Sequence Analysis, DNA', 'Virus Release', 'Virus Replication'] | 28,771,128 | [['G05.360.340.358.840'], ['G16.527.200.400'], ['B04.123.205.600.500', 'B04.123.691.600.500', 'B04.820.578.438.500'], ['B04.123.660'], ['B03.440.400.425.625.625.100', 'B03.660.250.580.590.050'], ['D13.444.735.828'], ['E05.393.760.700'], ['G06.920.913'], ['G06.920.925']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Vermiform Appendix During the Repackaging Process from Umbilical Herniation to Fixation onto the Right Posterior Abdomen: A Study of Human Fetal Horizontal Sections. | The anatomical position of the vermiform appendix varies among adults, and these variations are responsible for differences in the symptoms of appendicitis. However, to date no study has examined how and when these variations occur during fetal development. The present study examined horizontal sections of 27 midterm f... | ['Abdomen', 'Appendix', 'Cadaver', 'Fetal Development', 'Hernia, Umbilical', 'Humans', 'Intestines'] | 31,576,606 | [['A01.923.047'], ['A03.556.124.526.209.290', 'A03.556.249.249.209.290'], ['C23.550.260.224'], ['G07.345.500.325.235', 'G08.686.784.170.157'], ['C16.614.378', 'C23.300.707.374.937.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.556.124']] | ['Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
An orthogeriatric collaborative intervention program for fragility fractures: a retrospective cohort study. | BACKGROUND: This retrospective cohort study aims to investigate the impact of regular pre- and postoperative geriatric input into the management of geriatric patients with hip fracture, with specific interests in morbidity and mortality.METHODS: Patients with hip fracture (n = 548) older than 60 years were identified w... | ['Activities of Daily Living', 'Aged, 80 and over', 'Case-Control Studies', 'Chi-Square Distribution', 'Female', 'Frail Elderly', 'Geriatric Assessment', 'Hip Fractures', 'Humans', 'Length of Stay', 'Male', 'Patient Care Team', 'Postoperative Complications', 'Recovery of Function', 'Retrospective Studies'] | 22,002,614 | [['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100.080'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['M01.060.116.100.540'], ['E05.318.308.225', 'I... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Genetic variation among the Mapuche Indians from the Patagonian region of Argentina: mitochondrial DNA sequence variation and allele frequencies of several nuclear genes. | DNA samples from 60 Mapuche Indians, representing 39 maternal lineages, were genetically characterized for (1) nucleotide sequences of the mtDNA control region; (2) presence or absence of a nine base duplication in mtDNA region V; (3) HLA loci DRB1 and DQA1; (4) variation at three nuclear genes with short tandem repeat... | ['Alleles', 'Argentina', 'Base Sequence', 'DNA Fingerprinting', 'DNA, Mitochondrial', 'Female', 'Gene Frequency', 'Genetic Markers', 'Genetic Variation', 'HLA-DQ Antigens', 'HLA-DQ alpha-Chains', 'HLA-DR Antigens', 'HLA-DRB1 Chains', 'Histocompatibility Antigens Class II', 'Humans', 'Indians, South American', 'Male', '... | 8,400,690 | [['G05.360.340.024.340.030'], ['Z01.107.757.077'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.318.740.225.500.500', 'E05.393.290', 'I01.198.780.937.375', 'N04.452.910.099.750'], ['D13.444.308.283.225'], ['G05.330'], ['D23.101.387', 'G05.695.450'], ['G05.365'], ['D12.776.395.550.509.400.430', 'D12.... | ['Phenomena and Processes [G]', 'Geographicals [Z]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
Effect of ethanol on carbohydrate metabolism. II. Influence on glucose tolerance in diabetic rats. | A single moderate dose (0.4 g per kg of body weight) of ethanol given orally with a glucose load resulted in exaggerated glucose intolerance and inhibition of glucose mediated-insulin response in mildly diabetic rats. | ['Animals', 'Blood Glucose', 'Diabetes Mellitus, Experimental', 'Ethanol', 'Glucose', 'Glucose Tolerance Test', 'Insulin', 'Insulin Secretion', 'Male', 'Rats', 'Time Factors'] | 703,320 | [['B01.050'], ['D09.947.875.359.448.500'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['D02.033.375'], ['D09.947.875.359.448'], ['E01.370.225.124.100.355', 'E01.370.374.355', 'E05.200.124.100.355'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['G03.442', 'G07.475'], ['B01.050.150.900... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The uncovering and characterization of a CCKoma syndrome in enteropancreatic neuroendocrine tumor patients. | OBJECTIVE: Neuroendocrine tumors in the pancreas and the gastrointestinal tract may secrete hormones which cause specific syndromes. Well-known examples are gastrinomas, glucagonomas, and insulinomas. Cholecystokinin-producing tumors (CCKomas) have been induced experimentally in rats, but a CCKoma syndrome in man has r... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Animals', 'Child', 'Cholecystokinin', 'Denmark', 'Female', 'Gastrinoma', 'Gastrins', 'Humans', 'Intestinal Neoplasms', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Neuroendocrine Tumors', 'Pancreas', 'Pancreatic Neoplasms', 'Rats', 'Stomach Neoplasms', 'Young Adult'] | 27,191,542 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050'], ['M01.060.406'], ['D06.472.317.152', 'D12.644.120'], ['Z01.542.816.124'], ['C04.557.470.200.025.290.500', 'C04.588.274.761.500.124', 'C04.588.322.475.500.124', 'C06.301.761.500.124', 'C06.689.667.500.124', 'C19.344.421.500.124... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Waist circumference and abdominal adipose tissue distribution: influence of age and sex. | BACKGROUND: The influence of age and sex on the distribution of abdominal adipose tissue for a given waist circumference (WC) is unclear.OBJECTIVE: The objective was to investigate the influence of age and sex on total (TAAT), visceral (VAT), and abdominal subcutaneous (ASAT) adipose tissue for a given WC.DESIGN: Body ... | ['Abdomen', 'Adipose Tissue', 'Adolescent', 'Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Aging', 'Body Composition', 'Body Constitution', 'Body Mass Index', 'Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Sex Characteristics', 'Sex Factors', 'Viscera', 'Waist-Hip Ratio'] | 15,941,883 | [['A01.923.047'], ['A10.165.114'], ['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G07.345.124'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['E01.370.600.115', 'G07.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.85... | ['Anatomy [A]', 'Named Groups [M]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The management of perforated gastric ulcers. | INTRODUCTION: Perforated gastric ulcers are potentially complicated surgical emergencies and appropriate early management is essential in order to avoid subsequent problems including unnecessary gastrectomy. The aim of this study was to examine the management and outcome of patients with gastric ulcer perforation under... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Digestive System Surgical Procedures', 'Female', 'Humans', 'Male', 'Middle Aged', 'Peptic Ulcer Perforation', 'Prospective Studies', 'Retrospective Studies', 'Stomach Ulcer'] | 23,454,244 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C06.405.469.275.800.698', 'C06.405.748.586.698'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['E05.318.372... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Synthesis of a pentasaccharide corresponding to the repeating unit of the exopolysaccharide from Cryptococcus neoformans serovar D. | The assembly of the pentasaccharide repeating unit of the exopolysaccharide from Cryptococcus neoformans serovar D (i.e. 1) is described. The glucuronic acid residue in 1 is introduced as a glucopyranoside and oxidized in a later stage of the synthesis. Thus, iodonium ion-assisted glycosylation of the partially protect... | ['Carbohydrate Sequence', 'Cryptococcus neoformans', 'Magnetic Resonance Spectroscopy', 'Molecular Sequence Data', 'Oligosaccharides', 'Polysaccharides'] | 9,007,267 | [['G02.111.570.160', 'L01.453.245.667.160'], ['B01.300.381.258.366', 'B01.300.930.316.366'], ['E05.196.867.519'], ['L01.453.245.667'], ['D09.698.629'], ['D09.698']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
On the determination of evolutionary outcomes directly from the population dynamics of the resident. | In order to determine the possible evolutionary behaviour of an ecological system using adaptive dynamics, it is necessary in an ab initio calculation to find the fitness and its derivatives at a singular point. It has been suggested that the possible evolutionary behaviour can be predicted directly from the resident p... | ['Animals', 'Biological Evolution', 'Ecosystem', 'Models, Biological', 'Population Dynamics'] | 20,676,890 | [['B01.050'], ['G05.045', 'G16.075'], ['G16.500.275.157', 'N06.230.124'], ['E05.599.395'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Prediction of the ripening times of ewe's milk cheese by multivariate regression analysis of capillary electrophoresis casein fractions. | The effect of the ripening time on the proteolytic process in cheeses made from ewe's milk during a 139-day ripening period was monitored by the use of capillary electrophoresis of pH 4.6 insoluble fraction. Totals of 18 and 21 peaks were recognized and matched in the electropherograms obtained with a fused-silica capi... | ['Analysis of Variance', 'Animals', 'Caseins', 'Cheese', 'Electrophoresis, Capillary', 'Female', 'Food Handling', 'Hydrogen-Ion Concentration', 'Peptide Hydrolases', 'Regression Analysis', 'Sheep', 'Time Factors'] | 17,032,040 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['D12.776.256.159.750.207', 'D12.776.744.150'], ['G07.203.200.500.444', 'G07.203.300.350.300.444', 'J02.350.500.444', 'J02.500.350.300.444'], ['E05.196.401.190', 'E05.301.300.190'], ['J01.576.423.200'], ['G02.300'], ['D08.811.277.656'], ['... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Creatinine assays: time for action? | BACKGROUND: Major differences in creatinine results between different laboratories and apparent inaccuracies when using commercial lyophilized standards were noted. In order to assess the variation and accuracy of the different methods we conducted a local audit.METHODS: To establish the variation between methods, plas... | ['Autoanalysis', 'Blood Chemical Analysis', 'Creatinine', 'Humans', 'Mass Spectrometry', 'Reproducibility of Results', 'Sensitivity and Specificity'] | 12,564,843 | [['E05.059'], ['E01.370.225.124.100', 'E05.200.124.100'], ['D03.383.129.308.207'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.566'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Rifaximin Redux: treatment of recurrent Clostridium difficile infections with rifaximin immediately post-vancomycin treatment. | We report our continued experience with rifaximin as a post-vancomycin treatment strategy in six patients with multiple recurrences of C. difficile infection (CDI). Four of the six patients (67%) had no further diarrhea episodes, but two patients failed shortly after or during the rifaximin treatment. C. difficile isol... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anti-Bacterial Agents', 'Clostridioides difficile', 'Clostridium Infections', 'Drug Therapy, Combination', 'Enterocolitis, Pseudomembranous', 'Female', 'Gastrointestinal Agents', 'Humans', 'Male', 'Microbial Sensitivity Tests', 'Rifamycins', 'Rifaximin', 'Secondary Prevention', '... | 19,698,797 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085'], ['B03.353.625.657.500'], ['C01.150.252.410.222'], ['E02.319.310'], ['C01.150.252.410.222.310', 'C06.405.205.596.800', 'C06.405.469.363.800'], ['D27.505.954.483'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.875.5... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Behavioral consequences of radiation exposure to simulated space radiation in the C57BL/6 mouse: open field, rotorod, and acoustic startle. | Two experiments were carried out to investigate the consequences of exposure to proton radiation, such as might occur for astronauts during space flight. C57BL/6 mice were exposed, either with or without 15-g/cm2 aluminum shielding, to 0-, 3-, or 4-Gy proton irradiation mimicking features of a solar particle event. Irr... | ['Animals', 'Auditory Pathways', 'Behavior, Animal', 'Dose-Response Relationship, Radiation', 'Exploratory Behavior', 'Female', 'Mice', 'Mice, Inbred C57BL', 'Models, Biological', 'Motor Skills', 'Protons', 'Psychomotor Performance', 'Random Allocation', 'Reflex, Startle', 'Space Flight', 'Time Factors'] | 12,641,177 | [['B01.050'], ['A08.612.220.110'], ['F01.145.113'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['F01.145.387', 'F01.658.370'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'], ['E... | ['Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Characterization and favorable in vivo properties of heterodimeric soluble IL-15·IL-15Rá cytokine compared to IL-15 monomer. | Interleukin-15 (IL-15), a 114-amino acid cytokine related to IL-2, regulates immune homeostasis and the fate of many lymphocyte subsets. We reported that, in the blood of mice and humans, IL-15 is present as a heterodimer associated with soluble IL-15 receptor á (sIL-15Rá). Here, we show efficient production of this no... | ['Amino Acid Sequence', 'Animals', 'Binding Sites', 'Cell Proliferation', 'Chromatography, High Pressure Liquid', 'Female', 'Glycosylation', 'HEK293 Cells', 'Humans', 'Immunoblotting', 'Interleukin-15', 'Interleukin-15 Receptor alpha Subunit', 'Killer Cells, Natural', 'Mice', 'Mice, Inbred C57BL', 'Molecular Sequence D... | 23,649,624 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.120'], ['G04.161.750', 'G07.345.249.410.750'], ['E05.196.181.400.300'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.320', 'E05.601.470.320... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Evaluation of preoperative ProstaScint scans in the prediction of nodal disease. | Diagnostic methods are limited for detecting microscopic soft tissue metastases in patients with prostate cancer. Previous studies using (111)Indium Capromab Pendetide (ProstaScint scan) analyzed patients with extensive localized tumor (prostate specific antigen (PSA) >20 ng/ml) not optimal for surgical therapy. We eva... | ['Adenocarcinoma', 'Antibodies, Monoclonal', 'False Positive Reactions', 'Humans', 'Indium Radioisotopes', 'Lymphatic Metastasis', 'Male', 'Neoplasm Staging', 'Predictive Value of Tests', 'Preoperative Care', 'Prostate-Specific Antigen', 'Prostatic Neoplasms', 'Radionuclide Imaging', 'Sensitivity and Specificity'] | 12,497,003 | [['C04.557.470.200.025'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E01.354.506'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.496.749.460'], ['C04.697.650.560', 'C23.550.727.650.560'], ['E01.789.625'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', ... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Genetic basis of antimicrobial drug resistance in clinical isolates of Salmonella enterica serotype Hadar from a Spanish region. | The genetic bases of antimicrobial drug resistance (R) of 79 Salmonella enterica serotype Hadar clinical isolates (recovered during 1995-2001 in a Spanish region) was investigated. The isolates showed a limited genomic variation, as demonstrated by PFGE analysis using XbaI (three profiles, S>or=0.77) and BlnI (seven pr... | ['Drug Resistance, Multiple, Bacterial', 'Humans', 'Integrons', 'Microbial Sensitivity Tests', 'Plasmids', 'Salmonella enterica'] | 15,910,235 | [['G06.099.225.812', 'G06.225.347.812', 'G07.690.773.984.269.347.812', 'G07.690.773.984.300.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.111.570.080.708.330.200.500'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['G05.360.600'], ['B03.440.450.425.800.200', 'B03.660.250.150.710.160']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Activity-dependent cleavage of the K-Cl cotransporter KCC2 mediated by calcium-activated protease calpain. | The K-Cl cotransporter KCC2 plays a crucial role in neuronal chloride regulation. In mature central neurons, KCC2 is responsible for the low intracellular Cl(-) concentration ([Cl(-)](i)) that forms the basis for hyperpolarizing GABA(A) receptor-mediated responses. Fast changes in KCC2 function and expression have been... | ['Action Potentials', 'Analysis of Variance', 'Animals', 'Animals, Newborn', 'Calcium', 'Calcium Ionophores', 'Calpain', 'Cycloheximide', 'Cysteine Proteinase Inhibitors', 'Dipeptides', 'Dizocilpine Maleate', 'Dose-Response Relationship, Drug', 'Emetine', 'Excitatory Amino Acid Antagonists', 'Gene Expression Regulation... | 22,895,718 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['B01.050.050.282'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D27.505.519.562.374.100', 'D27.720.395.100'], ['D08.811.277.656.262.500.120', 'D08.811.277.656.300.200.120... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Loss of DAB2IP in RCC cells enhances their growth and resistance to mTOR-targeted therapies. | Targeted therapies using small-molecule inhibitors (SMIs) are commonly used in metastatic renal cell cancer (mRCC) patients; patients often develop drug resistance and eventually succumb to disease. Currently, understanding of mechanisms leading to SMIs resistance and any identifiable predictive marker(s) are still lac... | ['Adult', 'Aged', 'Animals', 'Carcinoma, Renal Cell', 'Cell Line, Tumor', 'Cell Proliferation', 'Drug Resistance, Neoplasm', 'Female', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Male', 'Middle Aged', 'Molecular Targeted Therapy', 'Protein Kinase Inhibitors', 'Signal Transduction', 'Sirolimus', 'TOR Serine-Thr... | 26,876,207 | [['M01.060.116'], ['M01.060.116.100'], ['B01.050'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G07.690.773.984.395'], ['G05.3... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Cloning and expression of an A1 adenosine receptor from rat brain. | We have used the polymerase chain reaction technique to selectively amplify guanine nucleotide-binding regulatory protein (G protein)-coupled receptor cDNA sequences from rat striatal mRNA, using sets of highly degenerate primers derived from transmembrane sequences of previously cloned G protein-coupled receptors. A n... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Brain', 'Cloning, Molecular', 'Corpus Striatum', 'DNA', 'Gene Library', 'Immunohistochemistry', 'Molecular Sequence Data', 'Polymerase Chain Reaction', 'Protein Conformation', 'RNA, Messenger', 'Radioligand Assay', 'Rats', 'Receptors, Purinergic', 'Sequence Homology,... | 1,857,334 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A08.186.211'], ['E05.393.220'], ['A08.186.211.200.885.287.249.487'], ['D13.444.308'], ['G05.360.325'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Preliminary research on Zhang Song's Jiu yuan fang | Written by Zhang Song, a physician in the Southern Song Dynasty, Jiu yuan fang (Formulary of Exploring Cause) was a lost clinical experienced formulary book. Totally 124 items of its original texts were quoted and remained in some other ancient Chinese medical books, such as Fu zai wan an fang (Formulary for Absolute S... | ['Books', 'History, Medieval', 'Humans', 'Medicine, Chinese Traditional', 'Physicians'] | 30,032,584 | [['L01.178.682.192'], ['K01.400.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.190.488.585.520', 'I01.076.201.450.654.558.520'], ['M01.526.485.810', 'N02.360.810']] | ['Information Science [L]', 'Humanities [K]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 |
Observing others: multiple action representation in the frontal lobe. | Observation of actions performed by others activates monkey ventral premotor cortex, where action meaning, but not object identity, is coded. In a functional MRI (fMRI) study, we investigated whether other monkey frontal areas respond to actions performed by others. Observation of a hand grasping objects activated four... | ['Animals', 'Frontal Lobe', 'Humans', 'Interpersonal Relations', 'Macaca mulatta', 'Magnetic Resonance Imaging', 'Male', 'Motion Perception', 'Motor Activity', 'Neurons', 'Videotape Recording'] | 16,224,029 | [['B01.050'], ['A08.186.211.200.885.287.500.270'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['E01.370.350.825.500'], ['F02.463.593.932.567'], ['F01.145.632', 'G11.427.410.698'], ['A08.675', 'A11.671'], ['J01.897.280.500.846.734', 'J01.897... | ['Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Phosphorylated Rasal2 facilitates breast cancer progression. | BACKGROUND: Rasal2 has diametric effects on progression of oestrogen receptor-positive (ER+) and -negative (ER-) breast cancers. The relevant causes are unknown. It is also unknown whether the effects of Rasal2 are mediated by an exosome-transport process.METHODS: Exosomes were purified from breast cancer cells and ide... | ['Animals', 'Biomarkers, Tumor', 'Breast Neoplasms', 'Cell Line, Tumor', 'Disease Models, Animal', 'Exosomes', 'Extracellular Vesicles', 'Female', 'GTPase-Activating Proteins', 'Gene Expression', 'Gene Knockdown Techniques', 'Gene Targeting', 'Humans', 'Immunohistochemistry', 'Mice', 'Models, Biological', 'Phosphorylat... | 31,759,919 | [['B01.050'], ['D23.101.140'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.284.295.588.750', 'A11.284.430.214.190.875.190.880.495'], ['A11.284.295.588'], ['D12.644.360.325.150', 'D12.776.476.325.150'], ['G05.297'], ['E05.393.335.500'],... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
F response and H reflex for monitoring nerve block during epidural analgesia with ropivacaine. | The effect of a single epidural injection of ropivacaine on the motor and sensory function controlled from the L5/S1 level was investigated in 28 male volunteers. Concentrations of 1%, 0.75%, or 0.5% ropivacaine, 20 mL, administered at the L2/3 level were studied. Motor function was assessed quantitatively (measurement... | ['Adult', 'Amides', 'Analgesia, Epidural', 'Anesthetics, Local', 'H-Reflex', 'Humans', 'Male', 'Monitoring, Physiologic', 'Motor Neurons', 'Nerve Block', 'Reference Values', 'Ropivacaine'] | 8,109,767 | [['M01.060.116'], ['D02.065'], ['E03.091.080'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['G11.561.731.643.474'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.520'], ['A08.675.655.500', 'A11.671.655.500'], ['E03.155.086.711', 'E04.525.210.550'], ['E05.978.810'... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Effect of ghrelin on angiotensin II induced human umbilicus vein endothelial cell oxidative stress and endothelial cell injury. | OBJECTIVE: To determine the effect of ghrelin on protecting the human umbilical vein endothelial cells (HUVEC) from injury by angiotensin II (Ang II) in vitro.METHODS: (1) HUVEC was incubated for 24 h with AngII whose final concentration in the medium varied from 10⁻⁹ to 10⁻⁶ mol/L or pretreated with 10⁻⁹ to 10⁻⁶ mol/L... | ['Angiotensin II', 'Apoptosis', 'Cell Survival', 'Cells, Cultured', 'Ghrelin', 'Human Umbilical Vein Endothelial Cells', 'Humans', 'Nitric Oxide Synthase Type III', 'Oxidative Stress', 'Reactive Oxygen Species'] | 21,051,828 | [['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['G04.146.954.035'], ['G04.346'], ['A11.251'], ['D06.472.699.301', 'D12.644.548.322'], ['A11.436.275.682'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.664.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleolytic processing of aberrant replication intermediates by an Exo1-Dna2-Sae2 axis counteracts fork collapse-driven chromosome instability. | Problems during DNA replication underlie genomic instability and drive malignant transformation. The DNA damage checkpoint stabilizes stalled replication forks thus counteracting aberrant fork transitions, DNA breaks and chromosomal rearrangements. We analyzed fork processing in checkpoint deficient cells by coupling p... | ['Cell Cycle Proteins', 'Checkpoint Kinase 2', 'Chromosomal Instability', 'Chromosomes, Fungal', 'DNA Helicases', 'DNA Repair', 'DNA Replication', 'DNA, Fungal', 'Endonucleases', 'Exodeoxyribonucleases', 'G1 Phase Cell Cycle Checkpoints', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins'] | 27,672,038 | [['D12.776.167'], ['D08.811.913.696.620.682.700.145'], ['C23.550.210.110', 'C23.550.362.180', 'G05.365.590.175.165', 'G05.370.180'], ['A11.284.187.360', 'A19.311', 'G05.360.162.360'], ['D08.811.277.040.025.159', 'D08.811.399.340'], ['G02.111.222', 'G05.219'], ['G02.111.225', 'G05.226'], ['D13.444.308.300'], ['D08.811.2... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Distribution of the streptomycin-resistance transposon Tn5393 among phylloplane and soil bacteria from managed agricultural habitats. | The distribution of the strA-strB streptomycin-resistance (Smr) genes associated with Tn5393 was examined in bacteria isolated from the phylloplane and soil of ornamental pear and tomato. Two ornamental pear nurseries received previous foliar applications of streptomycin, whereas the tomato fields had no prior exposure... | ['Bacteria', 'Crops, Agricultural', 'DNA Probes', 'DNA Transposable Elements', 'Drug Resistance, Microbial', 'Drug Resistance, Multiple', 'Fruit', 'Lycopersicon esculentum', 'Nucleic Acid Hybridization', 'Phenotype', 'Plant Leaves', 'Soil Microbiology', 'Streptomycin', 'Tetracycline Resistance'] | 7,585,356 | [['B03'], ['B01.650.160', 'G07.203.300.300', 'J02.500.300'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['D13.444.308.520', 'G02.111.570.080.708.330.200', 'G05.360.080.708.330.200', 'G05.360.340.024.425.200'], ['G06.225', 'G07.690.773.984.269'], ['G07.690.773.984.300'], ['A18.024.500', '... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 |
A hypothesis to explain childhood cancers near nuclear power plants. | Over 60 epidemiological studies world-wide have examined cancer incidences in children near nuclear power plants (NPPs): most of them indicate leukemia increases. These include the 2008 KiKK study commissioned by the German Government which found relative risks (RR) of 1.6 in total cancers and 2.2 in leukemias among in... | ['Female', 'Humans', 'Infant', 'Infant, Newborn', 'Neoplasms', 'Nuclear Power Plants', 'Pregnancy'] | 24,054,083 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C04'], ['E07.710.600.500', 'J01.780.600', 'J03.540.680.600'], ['G08.686.784.769']] | ['Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Activated protein C mediates a healing phenotype in cultured tenocytes. | Tendon injuries cause considerable morbidity in the general adult population. The tenocytes within the tendon have the full capacity to heal the tendon intrinsically. Activated protein C (APC) plays an important role in coagulation and inflammation and more recently has been shown to promote cutaneous wound healing. In... | ['Animals', 'Antigens, CD', 'Cell Movement', 'Cell Proliferation', 'Cells, Cultured', 'Collagen Type I', 'Endothelial Protein C Receptor', 'Enzyme Activation', 'Humans', 'Matrix Metalloproteinase 2', 'Mitogen-Activated Protein Kinases', 'Phenotype', 'Protein C', 'Receptors, Cell Surface', 'Sheep', 'Tendons', 'Wound Hea... | 18,466,356 | [['B01.050'], ['D23.050.301.264.035', 'D23.101.100.110'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['A11.251'], ['D05.750.078.280.300.100', 'D12.776.860.300.250.300.100'], ['D12.776.395.550.294', 'D12.776.543.550.294', 'D12.776.543.750.045'], ['G02.111.263', 'G03.328'], ['B01.050.150.900.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Photophysics of Calix[4]biscrown-based ditopic receptors of caesium containing one or two dioxocoumarin fluorophores. | The ditopic receptors Calix-COU1 and Calix-COU2 consist of a calix[4]biscrown containing one or two dioxycoumarin fluorophores, respectively, inserted into the crown. They can form 1:1 and 2:1 (metal:ligand) complexes with caesium ions. The photophysical properties of the 1:1 complexes can be explained by (i) cation tu... | ['Algorithms', 'Calixarenes', 'Cesium', 'Chelating Agents', 'Coumarins', 'Crown Ethers', 'Models, Chemical', 'Phenols', 'Spectrometry, Fluorescence', 'Spectrophotometry'] | 15,617,387 | [['G17.035', 'L01.224.050'], ['D04.345.025'], ['D01.268.549.125', 'D01.268.556.165', 'D01.552.528.160', 'D01.552.544.165'], ['D27.505.519.914.500', 'D27.720.832.500'], ['D03.383.663.283.446', 'D03.633.100.150.446'], ['D02.355.291.308', 'D04.345.051.500', 'D04.345.241.308'], ['E05.599.495'], ['D02.455.426.559.389.657'],... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effects of chronic estrogen treatment on dopamine concentrations and turnover in discrete brain nuclei of ovariectomized rats. | We investigated the effects of chronic estrogen treatment in ovariectomized rats on the concentration of dopamine in 33 discrete brain nuclei. In order to assess estrogen's influence on dopamine turnover, some of the rats were administered alpha-methyl-p-tyrosine. Estrogen treatment reduced the concentrations of dopami... | ['Animals', 'Brain', 'Castration', 'Dopamine', 'Estradiol', 'Estrogens', 'Female', 'Methyltyrosines', 'Rats'] | 7,219,894 | [['B01.050'], ['A08.186.211'], ['E04.270.282', 'E04.950.165'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D27.505.696.399.472.277'], ['D12.125.072.050.875.485'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effects on lipid serum levels of a 2-year adjuvant treatment with exemestane after tamoxifen in postmenopausal women with early breast cancer. | BACKGROUND: The third-generation aromatase inhibitor exemestane represents a new development in the treatment of estrogen-positive breast cancer. The aim of this study was to evaluate the effects on lipid profile and body composition of the shift from tamoxifen to exemestane.METHODS: After 2-3 years of tamoxifen adjuva... | ['Aged', 'Androstadienes', 'Antineoplastic Agents', 'Antineoplastic Agents, Hormonal', 'Aromatase Inhibitors', 'Biomarkers', 'Body Composition', 'Breast Neoplasms', 'Chemotherapy, Adjuvant', 'Cholesterol, HDL', 'Cholesterol, LDL', 'Cohort Studies', 'Estrogen Receptor Modulators', 'Female', 'Humans', 'Lipids', 'Middle A... | 19,046,724 | [['M01.060.116.100'], ['D04.210.500.054.079.129'], ['D27.505.954.248'], ['D27.505.954.248.169'], ['D27.505.519.389.870.300', 'D27.505.696.399.450.327.149', 'D27.505.696.399.450.855.300'], ['D23.101'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['C04.588.180', 'C17.800.090.500'], ['E02.186.170', 'E02.319.170'], ['D04.21... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Selection of monoclonal antibodies for the identification of lymphocyte surface antigens in the New World primate Saguinus oedipus oedipus (cotton top tamarin). | 32 monoclonal antibodies reactive with human CD antigens were tested against tamarin peripheral blood lymphocytes, ConA blasts and lymphoblastoid B cell lines derived from tamarin cells. Reagents that cross-react with MHC class I and II, B cells (CD20, -21 and -23), monocytes (CD14) and NK cells (CD16, -56) have been i... | ['Animals', 'Antibodies, Monoclonal', 'Antigens, CD', 'Cells, Cultured', 'Concanavalin A', 'Cross Reactions', 'Flow Cytometry', 'Humans', 'Lymphocyte Activation', 'Lymphocytes', 'Saguinus'] | 7,836,781 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.301.264.035', 'D23.101.100.110'], ['A11.251'], ['D12.776.503.499.500', 'D12.776.765.678.500'], ['G12.122.281'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Uric acid is a main electron donor to peroxidases in human blood plasma. | BACKGROUND: Peroxidases are widely distributed and have been isolated from many higher-order plants, animal tissues, yeast and microorganisms. During measurements of peroxidase activities in samples of human plasma, we noticed the presence of a compound in the plasma which was interfering with the peroxidase assay. In ... | ['Cellulose', 'Chromatography', 'Chromatography, High Pressure Liquid', 'Electrophoresis, Capillary', 'Ethanolamines', 'Humans', 'Hydrogen', 'Hydrogen Peroxide', 'Models, Chemical', 'Peroxidases', 'Spectrophotometry', 'Time Factors', 'Ultrafiltration', 'Uric Acid'] | 12,444,370 | [['D05.750.078.562.180', 'D09.698.365.180', 'D25.720.099.500', 'J01.637.051.720.099.500'], ['E05.196.181'], ['E05.196.181.400.300'], ['E05.196.401.190', 'E05.301.300.190'], ['D02.033.100.291', 'D02.033.375.291', 'D02.092.063.291'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.406', 'D01.362.340'], ['D01.2... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Serum cystatin C levels in Nigerian children: reference intervals and relationship to demographic and anthropometric variables. | BACKGROUND: Cystatin C has been recognized as a good marker of kidney function but reference ranges have not been determined in Nigerian children.OBJECTIVE: To determine the reference range of serum cystatin C in Nigerian children with no overt signs of kidney disease and to determine and compare the relationship of se... | ['Adolescent', 'Age Distribution', 'Anthropometry', 'Biomarkers', 'Child', 'Child, Preschool', 'Cohort Studies', 'Creatinine', 'Cystatin C', 'Demography', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'Male', 'Nigeria', 'Reference Values', 'Sex Distribution'] | 22,120,484 | [['M01.060.057'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['D23.101'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['D03.383.129.308.207'], ['D12.776.215.300'], ['I01.240', 'N01... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Add-on effect of Guizhi Fuling formula to mifepristone for endometriosis: A meta-analysis of randomized controlled trials. | BACKGROUND: Guizhi Fuling pill, a famous traditional Chinese herbal formula, has been widely used for treatment of gynecological diseases. This meta-analysis sought to evaluate the add-on effect of Guizhi Fuling capsule (GZFL) to mifepristone in women with endometriosis.METHODS: A comprehensively literature search was ... | ['Drug Therapy, Combination', 'Drugs, Chinese Herbal', 'Endometriosis', 'Female', 'Humans', 'Mifepristone', 'Pregnancy', 'Pregnancy Rate', 'Randomized Controlled Trials as Topic', 'Treatment Outcome'] | 31,415,429 | [['E02.319.310'], ['D20.215.784.500.350', 'D26.335'], ['C13.351.500.163'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.365.415.580'], ['G08.686.784.769'], ['E05.318.308.985.775', 'G08.686.705', 'N01.224.935.849', 'N06.850.505.400.975.775', 'N06.850.520.308.985.775'], ['E05.318.372.250.250.365.500', '... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Antitumor Effect of KX-01 through Inhibiting Src Family Kinases and Mitosis. | PURPOSE: KX-01 is a novel dual inhibitor of Src and tubulin. Unlike previous Src inhibitors that failed to show clinical benefit during treatment of breast cancer, KX-01 can potentially overcome the therapeutic limitations of current Src inhibitors through inhibition of both Src and tubulin. The present study further e... | ['Acetamides', 'Aneuploidy', 'Animals', 'Antineoplastic Agents', 'Apoptosis', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Disease Models, Animal', 'Female', 'G2 Phase Cell Cycle Checkpoints', 'Humans', 'Mitosis', 'Phosphorylation', 'Protein Kinase Inhibitors', 'Pyridines', 'Triple Negative Breast Neopla... | 27,737,538 | [['D02.065.064', 'D02.241.081.018.110'], ['C23.550.210.050', 'G05.365.590.175.050', 'G05.700.131'], ['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['G04.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cajal's contribution to the neurology of breathing. | Cajal, through his pioneering investigations, was able to characterize the location and connections of several brainstem nuclei. This, coupled with previous investigations by others, allowed him to formulate a concept of the microscopic anatomy of automatic respiration. | ['History, 19th Century', 'Humans', 'Neurology', 'Respiratory System', 'Spain'] | 12,598,955 | [['K01.400.504.937'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.600'], ['A04'], ['Z01.542.846']] | ['Humanities [K]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
We're off to see the genome. | We discuss some societal and legal ramifications of the human genetics revolution. Our reflections were stimulated by discussions among scientists, citizens and legal experts at a large public symposium. We outline key issues regarding oversight of genetic research on human subjects, banking of DNA data by governments ... | ['Databases, Factual', 'Databases, Nucleic Acid', 'Drug Industry', 'Ethics, Medical', 'Federal Government', 'Genetic Privacy', 'Genetic Research', 'Genetics, Behavioral', 'Genetics, Medical', 'Genome, Human', 'Government Regulation', 'Human Genome Project', 'Humans', 'Law Enforcement', 'Neonatal Screening', 'Prejudice'... | 9,731,523 | [['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['L01.313.500.750.300.188.400.300.500', 'L01.313.500.750.300.188.400.325.630', 'L01.470.750.750.300.500', 'L01.470.750.750.325.630'], ['J01.576.655.750'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['I01.409.137', 'I01.409.418.625', 'N03.540.348.500', 'N... | ['Information Science [L]', 'Technology, Industry, and Agriculture [J]', 'Humanities [K]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Th... | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
Loss of Discoidin Domain Receptor 1 Predisposes Mice to Periodontal Breakdown. | The discoidin domain receptors, DDR1 and DDR2, are nonintegrin collagen receptors and tyrosine kinases. DDRs regulate cell functions, and their extracellular domains affect collagen fibrillogenesis and mineralization. Based on the collagenous nature of dentoalveolar tissues, we hypothesized that DDR1 plays an important... | ['Animals', 'Collagen', 'Discoidin Domain Receptor 1', 'Humans', 'Mice', 'Mice, Knockout', 'Osteoclasts', 'Periodontal Atrophy', 'X-Ray Microtomography'] | 31,610,730 | [['B01.050'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D08.811.913.696.620.682.725.400.005.500', 'D12.776.543.750.630.005.500', 'D12.776.543.750.685.050.500', 'D12.776.543.750.705.880.300.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500.500'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A bacterial effector acts as a plant transcription factor and induces a cell size regulator. | Pathogenicity of many Gram-negative bacteria relies on the injection of effector proteins by type III secretion into eukaryotic cells, where they modulate host signaling pathways to the pathogen's benefit. One such effector protein injected by Xanthomonas into plants is AvrBs3, which localizes to the plant cell nucleus... | ['Amino Acid Sequence', 'Bacterial Proteins', 'Basic Helix-Loop-Helix Transcription Factors', 'Capsicum', 'Cell Enlargement', 'Cell Size', 'Chromatin Immunoprecipitation', 'Gene Expression Regulation, Plant', 'Gene Silencing', 'Molecular Sequence Data', 'Plant Leaves', 'Plant Proteins', 'Promoter Regions, Genetic', 'To... | 17,962,565 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['D12.776.260.103', 'D12.776.930.125'], ['B01.650.940.800.575.912.250.908.500.145'], ['G04.161.500', 'G07.345.249.410.500'], ['G04.325'], ['E05.393.170', 'E05.478.605.160'], ['G05.308.375'], ['G05.308.203.374'], ['L01.453.245.667'], ['A18.024.812'], ['D12.77... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Abscisic acid suppresses the highly occurred somatic homologous recombination in Arabidopsis rfc1 mutant. | The phytohormone abscisic acid (ABA) regulates many aspects of plant growth, including seed germination, root growth and cell division. Previous study indicates that ABA treatment increases DNA damage and somatic homologous recombination (HR) in Arabidopsis abo4/pol ? (aba overly-sensitive 4 /DNA polymerase ?) mutants.... | ['Abscisic Acid', 'Arabidopsis', 'Arabidopsis Proteins', 'Cyclin B', 'DNA Damage', 'Gene Expression Regulation, Plant', 'Genes, Reporter', 'Germination', 'Homologous Recombination', 'Mutation', 'Plant Growth Regulators', 'Plant Roots', 'Plants, Genetically Modified', 'Promoter Regions, Genetic', 'Replication Protein C'... | 24,053,948 | [['D02.241.223.268.034', 'D02.455.326.271.665.202.061', 'D02.455.426.392.368.367.379.249.024', 'D02.455.849.131.061', 'D02.455.849.765.521.500'], ['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['D12.644.360.262.120', 'D12.776.167.218.120', 'D12.776.476.262.120'], ['G05.200'], ['G05.308.375'], ['G05.360.3... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Maxillary chondrosarcoma (report of two cases). | Two cases of chondrosarcoma of the maxilla are reported together with the clinical and histological differential diagnosis. The origin of this rare tumour in the maxilla, a bone with exclusive membranous ossification, is discussed in accordance with the new concept of cell differentiation in neoplasia. | ['Adult', 'Chondrosarcoma', 'Humans', 'Male', 'Maxillary Neoplasms'] | 3,346,601 | [['M01.060.116'], ['C04.557.450.565.280', 'C04.557.450.795.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.149.721.450.601', 'C05.116.231.754.450.601', 'C05.500.499.601', 'C05.500.693.528', 'C07.320.515.601', 'C07.320.660.601']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Pharmacokinetic studies on ceftezole. | The adult volunteers were given 1 g of ceftezole as a single intramuscular dose to investigate the pharmacokinetic profile of this new cephalosporin. The peak average serum concentration, reached 2 h after injection, was 22.5 micrograms/ml, and the t1/2 beta was 1.5 h; urinary recovery was over 80% within 24 h, the maj... | ['Adult', 'Cefazolin', 'Humans', 'Injections, Intramuscular', 'Kinetics', 'Male', 'Middle Aged'] | 3,802,300 | [['M01.060.116'], ['D02.065.589.099.249.160', 'D02.886.665.074.160', 'D03.633.100.300.249.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.319.267.530.460'], ['G01.374.661', 'G02.111.490'], ['M01.060.116.630']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
CD34 expression in native human acute myelogenous leukemia blasts: differences in CD34 membrane molecule expression are associated with different gene expression profiles. | BACKGROUND: The stem cell marker CD34 is expressed by leukemia blasts only for a subset of patients with acute myelogenous leukemia (AML). It is still controversial as to whether CD34 expression (defined as at least 10-20% positive cells) has any prognostic effect in patients with AML who receive intensive chemotherapy... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antigens, CD34', 'Cluster Analysis', 'Female', 'Flow Cytometry', 'Gene Expression Profiling', 'Gene Expression Regulation, Leukemic', 'Hematopoietic Stem Cells', 'Humans', 'Leukemia, Myeloid, Acute', 'Leukocytes, Mononuclear', 'Male', 'Middle Aged', 'Oligonucleotide Array Sequenc... | 15,668,952 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D23.050.301.264.035.134', 'D23.101.100.110.134'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Spinal anesthesia with hypobaric bupivacaine for knee arthroscopies: effect of posture on motor block. | BACKGROUND AND OBJECTIVES: The clinical impact of patient positioning on motor block during unilateral spinal anesthesia was the focus of our study. It was assumed that a 45 degrees rotation toward the prone position would minimize blocking the ventral motor roots compared with using the conventional lateral decubitus ... | ['Anesthesia, Spinal', 'Anesthetics, Local', 'Arthroscopy', 'Bupivacaine', 'Female', 'Humans', 'Knee Joint', 'Male', 'Middle Aged', 'Motor Neurons', 'Nerve Block', 'Posture', 'Spinal Nerve Roots'] | 11,172,508 | [['E03.155.086.331'], ['D27.505.696.277.100.200', 'D27.505.696.663.850.025', 'D27.505.954.427.210.100.200'], ['E01.370.388.250.070', 'E04.502.250.070', 'E04.555.113'], ['D02.065.199.239', 'D02.092.146.113.239'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['M01.060.116.630'], ['A08.675.655.500... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
An interpretation of the neonatal period definition obtained with echocardiographic examination by using change point regression analysis. | BACKGROUND: We had reported on the left ventricular end-diastolic dimension (LVDd) in normal children from the premature/neonatal period to the adolescence period by using two-dimensional echocardiography, and formulated equations to evaluate normal LVDd values by using body height as an index. There was an inflection ... | ['Cardiac Volume', 'Child Development', 'Echocardiography', 'Female', 'Gestational Age', 'Heart Ventricles', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Reference Values', 'Regression Analysis', 'Ventricular Function, Left'] | 30,149,477 | [['G09.330.380.249'], ['F01.525.200', 'G07.345.374.750'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['G07.345.500.325.235.968', 'G08.686.320'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['E05.978.810'], ['E05.318.740.750', 'N05.7... | ['Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cognitive function after two doses of cranial irradiation for acute lymphoblastic leukaemia. | The cognitive function of 23 children given cranial irradiation in a dose of 24 Gy was compared with that of 41 given 18 Gy. No significant differences were found in intellectual function or in mean number of intelligence quotient points lost between patients in the two treatment groups. A reduction in the dose of cran... | ['Child, Preschool', 'Cranial Irradiation', 'Female', 'Humans', 'Intelligence', 'Male', 'Precursor Cell Lymphoblastic Leukemia-Lymphoma', 'Radiotherapy Dosage'] | 1,953,013 | [['M01.060.406.448'], ['E02.815.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.543'], ['C04.557.337.428.600', 'C15.604.515.560.600', 'C20.683.515.528.600'], ['E02.815.639']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Mesial-temporal lesions in patients with neurosyphilis]. | BACKGROUND AND PURPOSE: Evaluate and describe clinical and imaging findings in two patients with mesial-temporal changes in a context of Neurosyphilis.METHODS: The clinical files of two patients with mesial-temporal lesions in the context of Neurosyphilis were reviewed, gathering information about sex, age, clinical pr... | ['Adult', 'Humans', 'Male', 'Middle Aged', 'Neurosyphilis', 'Temporal Lobe'] | 23,177,588 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C01.150.252.223.600', 'C01.150.252.400.794.840.500.750', 'C01.150.252.400.840.500.750', 'C01.207.180.600', 'C10.228.228.180.600'], ['A08.186.211.200.885.287.500.863']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Isolation and crystal structure of marcanine A from Polyalthia plagioneura. | Marcanine A was isolated from the stems of Polyalthia plagioneura as light yellow crystals. The molecular and crystal structures have been determined by 1D,2D-NMR and X-ray diffraction analysis. It crystallizes in the triclinic system, space group P-1 with a = 5.2140(5)?, b = 10.1871(11)?, c = 11.0709(13)?, á = 110.452... | ['Anthraquinones', 'Antineoplastic Agents', 'Cell Line, Tumor', 'Cell Proliferation', 'Crystallization', 'Crystallography, X-Ray', 'Humans', 'Hydrogen Bonding', 'Molecular Structure', 'Plant Stems', 'Polyalthia'] | 20,877,226 | [['D02.455.426.559.847.117.159', 'D02.806.100', 'D04.615.117.159'], ['D27.505.954.248'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['E05.196.300', 'G02.171'], ['E05.196.309.742.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.282'], ['G02.111.570', 'G02.466'], ['A18.02... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Operational and financial performance of newly established hospices. | The objective of the study was to examine the financial and operating performance of newly established, free- standing hospices relative to existing, freestanding hospices. A nonparametric median test was used to compare the median values of operating and financial performance measures between newly established hospice... | ['Costs and Cost Analysis', 'Efficiency, Organizational', 'Financial Management', 'Hospice Care', 'Hospices', 'Humans', 'Length of Stay', 'Organizational Case Studies', 'Organizational Innovation', 'Organizations, Nonprofit', 'Reimbursement Mechanisms', 'United States'] | 17,060,288 | [['N03.219.151'], ['N04.452.209.500'], ['N03.219.463'], ['E02.760.905.400', 'N02.421.585.905.400'], ['N02.278.421.556.185', 'N02.421.143.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['N03.349.380.710', 'N05.715.360.455'], ['N04.452.610'], ['N03.540.630'], ['N03.219... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Exploring pathogenesis in subjects with subjective Tinnitus having kidney deficiency pattern in terms of Traditional Chinese Medicine based on serum metabolic profiles. | OBJECTIVE: To investigate the metabolic pathogenesis in subjects with subjective tinnitus (ST) having kidney deficiency pattern (KDP) (ST/KDP) in terms of Traditional Chinese Medicine.METHODS: Three groups of subjects, including healthy individuals, subjects with ST/KDP, and subjects who were healthy initially and then... | ['Adult', 'Aged', 'Biomarkers', 'Chromatography, High Pressure Liquid', 'Female', 'Glutamic Acid', 'Guanine', 'Humans', 'Kidney', 'Male', 'Mass Spectrometry', 'Metabolome', 'Metabolomics', 'Middle Aged', 'Orotic Acid', 'Serotonin', 'Serum', 'Taurine', 'Tinnitus', 'Young Adult'] | 32,185,996 | [['M01.060.116'], ['M01.060.116.100'], ['D23.101'], ['E05.196.181.400.300'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['D03.633.100.759.758.399.454'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['E05.196.566'], ['G03.500'], ['H01.158.201.586', 'H01.158.273.180.599', 'H01... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Respiratory hazard of Li-ion battery components: elective toxicity of lithium cobalt oxide (LiCoO2 | Rechargeable Li-ion batteries (LIB) are increasingly produced and used worldwide. LIB electrodes are made of micrometric and low solubility particles, consisting of toxicologically relevant elements. The health hazard of these materials is not known. Here, we investigated the respiratory hazard of three leading LIB com... | ['Administration, Inhalation', 'Air Pollutants', 'Animals', 'Biological Availability', 'Bronchoalveolar Lavage Fluid', 'Cobalt', 'Electric Power Supplies', 'Female', 'Fibrosis', 'Iron', 'Lithium', 'Lung', 'Mice, Inbred C57BL', 'Microscopy, Electron, Scanning', 'Oxides', 'Particle Size', 'Pneumonia', 'Titanium', 'Toxici... | 29,550,861 | [['E02.319.267.050'], ['D27.888.284.101'], ['B01.050'], ['G03.787.151', 'G07.690.725.129'], ['E05.927.100.500'], ['D01.268.556.185', 'D01.268.956.155', 'D01.552.544.185'], ['E07.305.124'], ['C23.550.355'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D01.268.549.450', 'D01.268.557.290', 'D01.552.528.480... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Changes in burn mortality in Bangladesh: Findings from Bangladesh Health and Injury Survey (BHIS) 2003 and 2016. | PURPOSE: This paper is focused to reflect the changes in burn mortality and events leading to fatal burn injuries.METHODS: Two national community-based cross sectional health and injury surveys were done in Bangladesh during 2003 and 2016. Similar methodology had been followed in both the surveys. Multistage cluster sa... | ['Adolescent', 'Adult', 'Age Distribution', 'Agriculture', 'Bangladesh', 'Burns', 'Burns, Electric', 'Cause of Death', 'Cross-Sectional Studies', 'Female', 'Health Surveys', 'Humans', 'Male', 'Middle Aged', 'Population Growth', 'Rural Population', 'Sex Distribution', 'Young Adult'] | 29,887,350 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['J01.040'], ['Z01.252.245.131'], ['C26.200'], ['C26.200.239', 'C26.324.323'], ['E05.318.308.985.550.250', 'N01.224.935.698.100', 'N06.850.505.400.975.550.250', 'N06.850.520.308.985.550.250'], ['E05.318.372.500.875', 'N05.715.360.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Working Behind Wyoming's Carbon Curtain. | Dan Neal, formerly the Executive Director of the Equality State Policy Center in Casper, Wyoming, was presented the Lorin Kerr Award by the Occupational Health and Safety Section of the American Public Health Association at its annual meeting in November 2014. The Kerr Award recognizes individuals who have stepped up t... | ['Awards and Prizes', 'Coal Mining', 'Humans', 'Occupational Health', 'Politics', 'Wyoming'] | 25,815,745 | [['K01.150'], ['J01.576.655.875.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.400.525'], ['I01.738'], ['Z01.107.567.875.560.925']] | ['Humanities [K]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 1 |
Limited in vivo production of type I or type III interferon after infection of macaques with vaccine or wild-type strains of measles virus. | The innate immune response to viral infections often includes induction of types I and III interferons (IFNs) and production of antiviral proteins. Measles is a severe virus-induced rash disease, but in vitro studies suggest that in the absence of defective interfering RNAs, neither wild-type (WT) nor vaccine strains o... | ['Animals', 'Cell Line', 'Chlorocebus aethiops', 'Immunity, Innate', 'Interferon Type I', 'Interferons', 'Macaca', 'Measles virus', 'Polymerase Chain Reaction', 'Vero Cells'] | 25,517,681 | [['B01.050'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['G12.450.564'], ['D12.644.276.374.440.890', 'D12.776.467.374.440.890', 'D23.529.374.440.890'], ['D12.644.276.374.440', 'D12.776.467.374.440', 'D23.529.374.440'], ['B01.050.150.900.649.313.988.400.112.199.120.510'], ['B04.820.480.93... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analysis of patient data from laboratories during the Ebola virus disease outbreak in Liberia, April 2014 to March 2015. | An outbreak of Ebola virus disease (EVD) in Liberia began in March 2014 and ended in January 2016. Epidemiological information on the EVD cases was collected and managed nationally; however, collection and management of the data were challenging at the time because surveillance and reporting systems malfunctioned durin... | ['Adolescent', 'Adult', 'Age Distribution', 'Child', 'Child, Preschool', 'Demography', 'Disease Outbreaks', 'Ebolavirus', 'Female', 'Hemorrhagic Fever, Ebola', 'History, 21st Century', 'Humans', 'Laboratories', 'Liberia', 'Logistic Models', 'Male', 'Mass Screening', 'Middle Aged', 'Risk Factors', 'Sex Distribution', 'Y... | 28,732,038 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.406'], ['M01.060.406.448'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['N06.850.290'], ['B04.820.480.937.300.200'], ['C01.925.782.417.415', 'C01.925.782.580.250.400'], ['K01.400.504.984'], ['B01.050.150.900.649.313.988.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Humanities [K]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 1 |
Sepsis programme successes are responsible for the increased detection of bacteraemia. | BACKGROUND: Escherichia coli bacteraemia reduction targets are challenging but, in West Wales, this was the key infection surrogate measure set by the local health board in 2013, prior to the introduction of a Welsh Government target. The initial plateau of cases was not maintained and prompted this review.AIM: To revi... | ['Bacteremia', 'Disease Management', 'Epidemiological Monitoring', 'Escherichia coli', 'Escherichia coli Infections', 'Humans', 'Wales'] | 29,654,811 | [['C01.150.252.100', 'C01.757.100', 'C23.550.470.790.500.100'], ['N04.590.607'], ['E05.318.375', 'N06.850.520.460'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C01.150.252.400.310.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.363.914']] | ['Diseases [C]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
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