Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Convergent translational evidence of a role for anandamide in amygdala-mediated fear extinction, threat processing and stress-reactivity. | Endocannabinoids are released 'on-demand' on the basis of physiological need, and can be pharmacologically augmented by inhibiting their catabolic degradation. The endocannabinoid anandamide is degraded by the catabolic enzyme fatty acid amide hydrolase (FAAH). Anandamide is implicated in the mediation of fear behavior... | ['Adaptation, Psychological', 'Adult', 'Alkanesulfonates', 'Amidohydrolases', 'Amygdala', 'Animals', 'Arachidonic Acids', 'Cannabinoid Receptor Antagonists', 'Conditioning, Psychological', 'Endocannabinoids', 'Enzyme Inhibitors', 'Extinction, Psychological', 'Fear', 'Female', 'Functional Neuroimaging', 'Genetic Associa... | 22,688,188 | [['F01.058'], ['M01.060.116'], ['D02.455.326.146.100.050', 'D02.886.645.600.055.050'], ['D08.811.277.087'], ['A08.186.211.180.090', 'A08.186.211.200.885.287.249.152'], ['B01.050'], ['D10.251.355.255.100', 'D10.251.355.310.166'], ['D27.505.519.625.085.750', 'D27.505.696.399.472.188.750'], ['F02.463.425.179'], ['D10.251.... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A comparative study of the enzymatic and toxic properties of venoms of the Asian lance-headed pit viper (Genus Trimeresurus). | 1. The lethalities, anticoagulant effects, hermorrhagic, thrombin-like enzyme, hyaluronidase, protease, arginine ester hydrolase, 5'-nucleotidase, L-amino acid oxidase, alkaline phosphomonoesterase, phosphodiesterase and phospholipase A activities of twenty-three samples of venoms from twelve species of Asian lance-hea... | ["5'-Nucleotidase", 'Alkaline Phosphatase', 'Amino Acid Oxidoreductases', 'Animals', 'Anticoagulants', 'Biological Availability', 'Carboxylic Ester Hydrolases', 'Crotalid Venoms', 'Endopeptidases', 'Hemorrhage', 'L-Amino Acid Oxidase', 'Mice', 'Phospholipases A', 'Phosphoric Diester Hydrolases', 'Thrombin'] | 2,553,329 | [['D08.811.277.352.650.600.600'], ['D08.811.277.352.650.035'], ['D08.811.682.664.500'], ['B01.050'], ['D27.505.954.502.119'], ['G03.787.151', 'G07.690.725.129'], ['D08.811.277.352.100'], ['D20.888.850.960.200', 'D23.946.833.850.960.200'], ['D08.811.277.656.300'], ['C23.550.414'], ['D08.811.682.664.500.677'], ['B01.050.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Valve area and cardiac output in aortic stenosis: quantification by magnetic resonance velocity mapping. | Valve area and cardiac output were determined with magnetic resonance (MR) velocity mapping in 12 patients with aortic stenosis. Heart catheterization, Doppler echocardiography, and indicator dilution were performed for comparison. Left ventricle could be catheterized in only nine patients; in these cases, MR measured ... | ['Aged', 'Aortic Valve', 'Aortic Valve Stenosis', 'Blood Flow Velocity', 'Blood Pressure', 'Cardiac Catheterization', 'Cardiac Output', 'Echocardiography, Doppler', 'Female', 'Humans', 'Indicator Dilution Techniques', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged'] | 8,237,760 | [['M01.060.116.100'], ['A07.541.510.110'], ['C14.280.484.048.750', 'C14.280.955.249'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.600.875.249', 'G09.330.380.076'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['E01.370.370.380.150', 'G09.330.380.124'], ['E01.370.350.130.750.220', 'E01.370.350.850.2... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Adjunctive Clavulanic Acid Abolishes the Cefazolin Inoculum Effect in an Experimental Rat Model of Methicillin-Sensitive Staphylococcus aureus Endocarditis. | We tested the ability of clavulanic acid to restore the efficacy of cefazolin against Staphylococcus aureus TX0117, which exhibits the cefazolin inoculum effect (CzIE). In the rat infective endocarditis model, the coadministration of cefazolin plus clavulanic acid resulted in a significant reduction of bacterial counts... | ['Animals', 'Anti-Bacterial Agents', 'Cefazolin', 'Clavulanic Acid', 'Endocarditis', 'Endocarditis, Bacterial', 'Methicillin', 'Microbial Sensitivity Tests', 'Rats', 'Staphylococcal Infections', 'Staphylococcus aureus', 'beta-Lactamases'] | 30,150,459 | [['B01.050'], ['D27.505.954.122.085'], ['D02.065.589.099.249.160', 'D02.886.665.074.160', 'D03.633.100.300.249.160'], ['D02.065.589.099.374.160', 'D03.633.100.300.374.160'], ['C14.280.282'], ['C01.150.252.245', 'C01.190.249', 'C14.260.249', 'C14.280.282.407'], ['D02.065.589.099.750.500', 'D02.886.108.750.500', 'D03.633... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Purification, characterisation and crystallisation of photosystem II from Thermosynechococcus elongatus cultivated in a new type of photobioreactor. | The thermophilic cyanobacterium Thermosynechococcus elongatus was cultivated under controlled growth conditions using a new type of photobioreactor, allowing us to optimise growth conditions and the biomass yield. A fast large-scale purification method for monomeric and dimeric photosystem II (PSII) solubilized from th... | ['Biomass', 'Chromatography, High Pressure Liquid', 'Chromatography, Liquid', 'Crystallization', 'Cyanobacteria', 'Electrophoresis, Polyacrylamide Gel', 'Oxygen', 'Photosystem II Protein Complex', 'Spectrophotometry, Atomic', 'Thylakoids', 'X-Ray Diffraction'] | 15,620,375 | [['G16.500.275.157.100', 'N06.230.124.100'], ['E05.196.181.400.300'], ['E05.196.181.400'], ['E05.196.300', 'G02.171'], ['B03.280', 'B03.440.475.100'], ['E05.196.401.402', 'E05.301.300.319'], ['D01.268.185.550', 'D01.362.670'], ['D05.500.562.488.750', 'D08.811.600.710.750', 'D12.776.543.930.500.750', 'D12.776.765.199.75... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A nanomolar-potency small molecule inhibitor of regulator of G-protein signaling proteins. | Regulators of G-protein signaling (RGS) proteins are potent negative modulators of signal transduction through G-protein-coupled receptors. They function by binding to activated (GTP-bound) Gá subunits and accelerating the rate of GTP hydrolysis. Modulation of RGS activity by small molecules is an attractive mechanism ... | ['Alkylation', 'Biocatalysis', 'Cell Survival', 'Cysteine', 'Flow Cytometry', 'GTP-Binding Protein alpha Subunits, Gi-Go', 'HEK293 Cells', 'Humans', 'Models, Molecular', 'Protein Conformation', 'RGS Proteins', 'Substrate Specificity', 'Thiadiazoles', 'Thiazolidinediones'] | 21,329,361 | [['G02.111.035', 'G02.607.094', 'G03.059'], ['G02.111.086', 'G02.130.500', 'G03.105'], ['G04.346'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.3... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Parallel recovery in a bilingual aphasic: a neurolinguistic and fMRI study. | In bilingual aphasics, the neural correlates of rehabilitation benefits and their generalization across languages are still scarcely understood. The authors present the case of a highly proficient bilingual woman (Flemish, L1/Italian, L2) with chronic aphasia who, in the presence of the same pattern of impairment in bo... | ['Aphasia', 'Cerebral Cortex', 'Female', 'Functional Laterality', 'Humans', 'Magnetic Resonance Imaging', 'Middle Aged', 'Multilingualism', 'Recovery of Function', 'Time Factors'] | 19,413,453 | [['C10.597.606.150.500.800.100', 'C23.888.592.604.150.500.800.100'], ['A08.186.211.200.885.287.500'], ['F02.830.297.425', 'G11.561.225.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['M01.060.116.630'], ['L01.559.423.452'], ['G16.757'], ['G01.910.857']] | ['Diseases [C]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
The McCoy laryngoscope, external laryngeal pressure, and their combined use. | The efficacy of the McCoy laryngoscope, external laryngeal pressure, and their combination to improve the laryngoscopic view was evaluated in 219 patients and compared with the Macintosh laryngoscope. An experienced laryngoscopist performed laryngoscopy twice using the Macintosh laryngoscope and the McCoy laryngoscope ... | ['Equipment Design', 'Humans', 'Laryngoscopes', 'Laryngoscopy', 'Pressure'] | 11,094,670 | [['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.230.220.525', 'E07.858.240.525'], ['E01.370.386.460', 'E01.370.388.250.525', 'E04.502.250.525', 'E04.580.373'], ['G01.374.715']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of gamma-radiation on a polyanhydride implant containing gentamicin sulfate. | Septacin, a polyanhydride implant containing gentamicin sulfate, was sterilized by gamma-radiation. Its copolymer molecular weight (M(w) by GPC) was increased after this radiation. No cross-linking was shown in the radiated samples as no gel content was found by the filtration method. The chemical structure as detected... | ['Absorbable Implants', 'Anti-Bacterial Agents', 'Cross-Linking Reagents', 'Gamma Rays', 'Gentamicins', 'Molecular Weight', 'Technology, Pharmaceutical'] | 11,790,485 | [['E07.695.025'], ['D27.505.954.122.085'], ['D27.720.470.410.210'], ['G01.358.500.505.300', 'G01.750.250.300', 'G01.750.750.400'], ['D09.408.051.374'], ['G02.494'], ['E05.916', 'J01.897.836']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Separation and on-line concentration of bisphenol A and alkylphenols by micellar electrokinetic chromatography with anionic surfactant. | Separation and on-line concentration of bisphenol A and three alkylphenols were investigated by micellar electrokinetic chromatography with the anionic surfactant, sodium dodecyl sulfate. The separation conditions were optimized by the simultaneous addition of the organic solvent and cyclodextrin to the running solutio... | ['Benzhydryl Compounds', 'Chromatography, Micellar Electrokinetic Capillary', 'Phenols', 'Sensitivity and Specificity', 'Surface-Active Agents'] | 14,558,616 | [['D02.455.426.559.389.115'], ['E05.196.181.500'], ['D02.455.426.559.389.657'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['D27.720.877']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effective AAV-mediated gene therapy in a mouse model of ethylmalonic encephalopathy. | Ethylmalonic encephalopathy (EE) is an invariably fatal disease, characterized by the accumulation of hydrogen sulfide (H(2)S), a highly toxic compound. ETHE1, encoding sulfur dioxygenase (SDO), which takes part in the mitochondrial pathway that converts sulfide into harmless sulfate, is mutated in EE. The main source ... | ['Animals', 'Brain Diseases, Metabolic, Inborn', 'Dependovirus', 'Dioxygenases', 'Disease Models, Animal', 'Genetic Therapy', 'Genetic Vectors', 'Humans', 'Mice', 'Mitochondrial Proteins', 'Purpura', 'Thiosulfates', 'Treatment Outcome'] | 22,903,887 | [['B01.050'], ['C10.228.140.163.100', 'C16.320.565.189', 'C18.452.132.100', 'C18.452.648.189'], ['B04.280.580.650.170'], ['D08.811.682.690.416'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E02.095.301', 'E05.393.420.301'], ['G05.360.337'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313... | ['Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Moral margins concerning the use of coercion in psychiatry. | In the closed wards of mental health institutions, moral decisions are made concerning the use of forced seclusion. In this article we focus on how these moral decisions are made and can be improved. We present a case study concerning moral deliberations on the use of seclusion and its prevention among nurses of a clos... | ['Adolescent', 'Adult', 'Coercion', 'Female', 'Hospitals, Psychiatric', 'Humans', 'Male', 'Morals', 'Netherlands', 'Organizational Culture', 'Patient Isolation', 'Psychiatric Nursing', 'Safety Management', 'Violence'] | 21,558,107 | [['M01.060.057'], ['M01.060.116'], ['I01.880.604.316', 'I01.880.630.200'], ['N02.278.421.556.508'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.500', 'K01.752.566'], ['Z01.542.651'], ['N04.452.606'], ['E02.770', 'N06.850.780.200.450.650'], ['H02.478.676.710', 'N02.421.533.778'], ['N04.452.871.900', 'N06.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Humanities [K]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
Comparison of monophasic and biphasic defibrillating pulse waveforms for transthoracic cardioversion. Biphasic Waveform Defibrillation Investigators. | All transthoracic defibrillators on the US market use nominally monophasic shock waveforms. However, biphasic waveforms have a lower defibrillation threshold than monophasic waveforms for transthoracic defibrillation of animals and for defibrillation of humans by implantable cardioverter defibrillators. The relative ef... | ['Adult', 'Aged', 'Aged, 80 and over', 'Canada', 'Chi-Square Distribution', 'Electric Countershock', 'Electrophysiology', 'Female', 'Humans', 'Male', 'Middle Aged', 'Prospective Studies', 'Tachycardia, Ventricular', 'United States', 'Ventricular Fibrillation'] | 7,762,500 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['Z01.107.567.176'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E02.331.350'], ['H01.158.344.528', 'H01.158.782.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
AT(1) and glutamatergic receptors in paraventricular nucleus support blood pressure during water deprivation. | Water deprivation activates sympathoexcitatory neurons in the paraventricular nucleus (PVN); however, the neurotransmitters that mediate this activation are unknown. To test the hypothesis that ANG II and glutamate are involved, effects on blood pressure (BP) of bilateral PVN microinjections of ANG II type 1 receptor (... | ['Angiotensin II Type 1 Receptor Blockers', 'Animals', 'Benzimidazoles', 'Blood Pressure', 'Excitatory Amino Acid Antagonists', 'Injections, Intraventricular', 'Kynurenic Acid', 'Male', 'Microinjections', 'Models, Biological', 'Paraventricular Hypothalamic Nucleus', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Angiotens... | 17,185,407 | [['D27.505.519.162.500'], ['B01.050'], ['D03.633.100.103'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['E02.319.267.530.550'], ['D03.066.942.505', 'D03.633.100.810.350.400'], ['E02.319.267.530.690', 'E05.591.570'], ['E05.599.395'], ['A08.186.211.180.497.342.400'... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Successful treatment of oral pemphigus vulgaris in an insulin-dependant geriatric patient. | OBJECTIVE: To present a clinical report of a patient treated with corticosteroids for oral pemphigus vulgaris (PV) lesions.BACKGROUND: PV is the type of pemphigus that most often affects the oral mucosa and tends not to appear in elderly people.METHODS: Two biopsies were needed for diagnosis. She was treated with oral ... | ['Biopsy', 'Clobetasol', 'Female', 'Humans', 'Pemphigus', 'Prednisone'] | 26,108,158 | [['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['D04.210.500.908.093.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.800.865.716', 'C20.111.736'], ['D04.210.500.745.432.719.702']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A role for left temporal pole in the retrieval of words for unique entities. | Both lesion and functional imaging studies have implicated sectors of high-order association cortices of the left temporal lobe in the retrieval of words for objects belonging to varied conceptual categories. In particular, the cortices located in the left temporal pole have been associated with naming unique persons f... | ['Adult', 'Architecture', 'Brain Mapping', 'Classification', 'Face', 'Female', 'Geography', 'Humans', 'Language', 'Male', 'Memory, Short-Term', 'Names', 'Pattern Recognition, Visual', 'Prosopagnosia', 'Radionuclide Imaging', 'Recognition, Psychology', 'Semantics', 'Temporal Lobe'] | 11,410,949 | [['M01.060.116'], ['J01.086'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['L01.100', 'L01.453.245.275'], ['A01.456.505'], ['H01.277.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['F02.463.425.540.407'], ['L01.559.598.400.556'], ['F02.463.593.524... | ['Named Groups [M]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 |
Defining fundamental niche dimensions of corals: synergistic effects of colony size, light, and flow. | The "fundamental niche" is the range of conditions under which an organism can survive and reproduce, measured in the absence of biotic interactions. Niche measurements are often based on statistical relationships between species presence and measured environmental variables, or inferred from measured responses of spec... | ['Animals', 'Anthozoa', 'Biomass', 'Ecosystem', 'Mathematics', 'Models, Biological', 'Photosynthesis', 'Population Density', 'Population Dynamics', 'Population Growth', 'Predictive Value of Tests', 'Species Specificity', 'Sunlight', 'Water Movements'] | 19,341,146 | [['B01.050'], ['B01.050.500.308.237'], ['G16.500.275.157.100', 'N06.230.124.100'], ['G16.500.275.157', 'N06.230.124'], ['H01.548'], ['E05.599.395'], ['G02.111.158.937', 'G02.111.669.700', 'G02.740.921', 'G03.191.937', 'G03.493.700', 'G03.800.700', 'G15.568'], ['N01.224.600', 'N06.850.505.400.600'], ['I01.240.600', 'N01... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Timing of neurodegeneration and beta-amyloid (Abeta) peptide deposition in the brain of aging kokanee salmon. | Brains of kokanee salmon (Oncorhynchus nerka kennerlyi) in one of four reproductive stages (sexually immature, maturing, sexually mature, and spawning) were stained with cresyl violet and silver stain to visualize neurodegeneration. These reproductive stages correlate with increasing somatic aging of kokanee salmon, wh... | ['Aging', 'Amyloid beta-Peptides', 'Animals', 'Brain', 'Cell Count', 'Female', 'Male', 'Nerve Degeneration', 'Neurons', 'Salmon'] | 12,360,580 | [['G07.345.124'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['B01.050'], ['A08.186.211'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['C23.550.737'], ['A08.675', 'A11.671'], ['B01.050.150.900.493.817.750.705']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluating Synergistic Effects of miR-34a Mimics in Combination with Other Therapeutic Agents in Cultured Non-Small Cell Lung Cancer Cells. | Tumor suppressor miRNAs such as miR-34a inhibit tumor growth by simultaneously regulating the expression of multiple important oncogenes across multiple oncogenic pathways and, therefore, provide a strong rationale for developing therapeutic miRNA mimics in combination with other therapeutic cancer agents to augment dr... | ['Antineoplastic Combined Chemotherapy Protocols', 'Apoptosis', 'Carcinoma, Non-Small-Cell Lung', 'Cell Line, Tumor', 'Cell Proliferation', 'Gene Expression Regulation, Neoplastic', 'Humans', 'MicroRNAs'] | 27,924,478 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['G04.146.954.035'], ['C04.588.894.797.520.109.220.249', 'C08.381.540.140.500', 'C08.785.520.100.220.500'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The combined use of acupuncture and UV irradiation in treating the neurological manifestations of lumbar osteochondrosis]. | Erythema field doses of UV radiation according to the segmental-metameric approach were applied in combination with acupuncture to treat lumbar osteochondrosis. Functional and clinical findings indicated the highest therapeutical response of the combination versus acupuncture or UV irradiation alone: 93% against 73.3% ... | ['Acupuncture Therapy', 'Adult', 'Back Pain', 'Combined Modality Therapy', 'Evaluation Studies as Topic', 'Humans', 'Lumbar Vertebrae', 'Middle Aged', 'Osteochondritis', 'Spondylitis', 'Ultraviolet Therapy'] | 1,833,880 | [['E02.190.044'], ['M01.060.116'], ['C23.888.592.612.107'], ['E02.186'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.834.519'], ['M01.060.116.630'], ['C05.116.791', 'C05.182.520', 'C17.300.182.520'], ['C01.160.762', 'C05.116.165.762', 'C05.116.900.853'], ['E02.774.945'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Characterization of a class 3 tyrosine kinase. | In an effort to identify unique tyrosine kinases found in human leukemia cell lines, we utilized polymerase chain reaction (PCR) technology and degenerate oligonucleotide primers to produce a cDNA library of kinase catalytic domains found in the human monocytic cell line AML-193. This search yielded a member of the cla... | ['Alleles', 'Amino Acid Sequence', 'Blotting, Northern', 'Blotting, Southern', 'Chromosome Mapping', 'Chromosomes, Human, Pair 1', 'Gene Frequency', 'Gene Library', 'Humans', 'Hybrid Cells', 'Leukemia, Monocytic, Acute', 'Molecular Sequence Data', 'Polymerase Chain Reaction', 'Polymorphism, Restriction Fragment Length'... | 1,373,877 | [['G05.360.340.024.340.030'], ['G02.111.570.060', 'L01.453.245.667.060'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['E05.393.183'], ['A11.284.187.520.300.235.240', 'G05.360.162.520.300.235.240'], ['G05.330'], ['G05.360.325'], ['B01.050.150.900.649.313... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Inosine 5'-monophosphate dehydrogenase 1 haplotypes and association with mycophenolate mofetil gastrointestinal intolerance in pediatric heart transplant patients. | MMF, the most commonly used adjuvant immunosuppressant in pediatric heart transplantation, has frequent GI adverse events. SNPs in inosine 5'-monophosphate dehydrogenase I (IMPDH1) may contribute to MMF GI intolerance. Phased haplotypes may have more utility than individual SNPs in candidate gene association studies fo... | ['Adolescent', 'Child', 'Child, Preschool', 'Female', 'Gastrointestinal Tract', 'Haplotypes', 'Heart Transplantation', 'Heterozygote', 'Humans', 'IMP Dehydrogenase', 'Infant', 'Linkage Disequilibrium', 'Male', 'Mycophenolic Acid', 'Pediatrics', 'Polymorphism, Single Nucleotide', 'Time Factors'] | 20,649,757 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['A03.556'], ['G05.380.360'], ['E04.100.376.475', 'E04.928.220.390', 'E04.936.450.475'], ['G05.380.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D08.811.682.047.820.450'], ['M01.060.703'], ['G05.348.500'], ['D02.241.081.193.678', 'D10.251.618'], ['H02.... | ['Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Temperature and humidity alter prolactin receptor expression in the skin of toad (Bufo bankorensis and Bufo melanostictus). | Bufo bankorensis and Bufo melanostictus, the only two species of Bufonidae genus in Taiwan, live in habitats that differ in altitude and humidity. This study tested the hypothesis that prolactin receptor (PRLR) expression responds to environmental change. Western blot analysis showed that the PRLR protein was widely di... | ['Adaptation, Physiological', 'Animals', 'Brain', 'Bufonidae', 'Environment', 'Female', 'Gene Expression', 'Humidity', 'Kidney', 'Lung', 'Male', 'Receptors, Prolactin', 'Skin', 'Temperature'] | 17,049,288 | [['G07.025', 'G16.012.500'], ['B01.050'], ['A08.186.211'], ['B01.050.150.900.090.180.210'], ['G16.500.275', 'N06.230'], ['G05.297'], ['G16.500.275.063.725.310', 'G16.500.750.775.310', 'N06.230.150.372', 'N06.230.300.100.725.310'], ['A05.810.453'], ['A04.411'], ['D12.776.543.750.720.600.710', 'D12.776.543.750.750.555.71... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Prophylaxis of ERCP-related pancreatitis: a randomized, controlled trial of somatostatin and gabexate mesylate. | BACKGROUND & AIMS: It still is debated whether post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis can be prevented by administering either somatostatin or gabexate mesylate. The aim of the study is to assess the efficacy of a 6.5-hour infusion of somatostatin or gabexate mesylate in preventing ERCP... | ['Aged', 'Aged, 80 and over', 'Chemoprevention', 'Cholangiopancreatography, Endoscopic Retrograde', 'Double-Blind Method', 'Female', 'Gabexate', 'Gastrointestinal Agents', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Pancreatitis', 'Somatostatin', 'Treatment Outcome'] | 15,290,665 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.319.162'], ['E01.370.350.700.715.200.200', 'E01.370.372.200.200', 'E01.370.372.250.200', 'E01.370.388.250.250.160', 'E04.210.240.160', 'E04.502.250.250.160'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D02.078.370.380'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Heparanase expression: a potential ancillary diagnostic tool for distinguishing between malignant cells and reactive mesothelium in body cavity effusions. | OBJECTIVE: Heparanase, an endoglycosidase that cleaves heparan sulphate, is frequently expressed in carcinomas and was suggested to play a role in cell invasion and metastasis. We investigated whether heparanase expression may serve as a reliable marker to discriminate benign mesothelial cells from malignant cells shed... | ['Adenocarcinoma', 'Biomarkers, Tumor', 'Epithelium', 'Extracellular Matrix', 'Exudates and Transudates', 'Gastrointestinal Neoplasms', 'Glucuronidase', 'Humans', 'Neoplasms', 'Retrospective Studies'] | 17,250,598 | [['C04.557.470.200.025'], ['D23.101.140'], ['A10.272'], ['A11.284.295.310'], ['A12.383'], ['C04.588.274.476', 'C06.301.371', 'C06.405.249'], ['D08.811.277.450.426'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.3... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Efficient access to highly pure â-amyloid peptide by optimized solid-phase synthesis. | Feasible and reproducible synthesis of full-length Aâ peptides has been one of the major challenges in Alzheimer's disease research. By using dimethyl sulfoxide as an anti-aggregation solvent and as an agent to promote double-coupling of two phenylalanine that frequently experience residual deletion, we developed a rel... | ['Amino Acids', 'Amyloid', 'Amyloid beta-Peptides', 'Benzothiazoles', 'Chromatography, High Pressure Liquid', 'Dimethyl Sulfoxide', 'Fluorenes', 'Fluorescent Dyes', 'Humans', 'Solid-Phase Synthesis Techniques', 'Solubility', 'Solvents', 'Spectrometry, Mass, Matrix-Assisted Laser Desorption-Ionization', 'Thiazoles'] | 22,799,493 | [['D12.125'], ['D05.500.049', 'D12.776.049'], ['D12.644.024', 'D12.776.049.407.249.500', 'D12.776.543.039.500'], ['D03.383.129.708.089', 'D03.633.100.185'], ['E05.196.181.400.300'], ['D02.886.640.150'], ['D02.455.426.559.847.389', 'D04.615.389'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['B01.050.150.900.649.313... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Decreasing size of cardiogenic oscillations reflects decreasing compliance of the respiratory system during long-term ventilation. | Part of the energy produced by the heartbeat is transferred to the lung and promotes intrapulmonary gas mixing. It is likely that this transmission in the form of local mechanical disturbances affects and reflects respiratory mechanics. The effects of the cardiogenic oscillations were studied in seven piglets during 7 ... | ['Animals', 'Animals, Newborn', 'Biological Clocks', 'Lung Compliance', 'Lung Volume Measurements', 'Myocardial Contraction', 'Pulmonary Ventilation', 'Respiration, Artificial', 'Swine', 'Time Factors'] | 14,578,363 | [['B01.050'], ['B01.050.050.282'], ['G07.180.562.094'], ['E01.370.386.700.475', 'G09.772.540'], ['E01.370.386.700.485'], ['G09.330.580', 'G11.427.494.570'], ['E01.370.386.700.660', 'G09.772.650'], ['E02.041.625', 'E02.365.647.729', 'E02.880.820'], ['B01.050.150.900.649.313.500.880'], ['G01.910.857']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Critical thermal minima, their spatial and temporal variation and response to hardening in Myrmica ants. | In a changing environment the ability to adjust physiological functions to new conditions might be especially valuable for long-living ectothermic animals such as ants. With a simple method for estimating critical thermal minima of Myrmica ants we assessed variation of the minima and their response to lowered temperatu... | ['Acclimatization', 'Animals', 'Ants', 'Behavior, Animal', 'Cold Temperature', 'Russia', 'Seasons'] | 19,274,309 | [['G07.025.133', 'G16.012.500.133'], ['B01.050'], ['B01.050.500.131.617.720.500.500.875.205'], ['F01.145.113'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['Z01.252.122.500', 'Z01.542.248.775'], ['G01.910.645.661', 'G16.500.27... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Tumors of the pineal region in children and adolescents. | The treatment of tumors in the pineal area remains controversial. There are two main approaches: Conservative treatment, consisting in CSF shunting and radiotherapy, and direct surgical removal. We report on 25 children (22 boys and 3 girls) aged between 4 and 20 years who underwent conservative treatment. The follow-u... | ['Adolescent', 'Adult', 'Brain Neoplasms', 'Cerebrospinal Fluid Shunts', 'Child', 'Child, Preschool', 'Combined Modality Therapy', 'Dysgerminoma', 'Ependymoma', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Microsurgery', 'Pineal Gland', 'Radiotherapy Dosage'] | 3,867,253 | [['M01.060.057'], ['M01.060.116'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['E04.035.188', 'E04.525.170'], ['M01.060.406'], ['M01.060.406.448'], ['E02.186'], ['C04.557.465.330.300'], ['C04.557.465.625.600.380.290', 'C04.557.470.670.380.290', 'C04.557.580.625.600.380.290'], ['E05.318.372.500.750.2... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
DOTAGA-trastuzumab. A new antibody conjugate targeting HER2/Neu antigen for diagnostic purposes. | Improved bifunctional chelating agents (BFC) are required for indium-111 radiolabeling of monoclonal antibodies (mAbs) under mild conditions to yield stable, target-specific agents. 2,2',2"-(10-(2,6-Dioxotetrahydro-2H-pyran-3-yl)-1,4,7,10-tetraazacyclododecane-1,4,7-triyl)triacetic acid (DOTAGA-anhydride) was evaluated... | ['Anhydrides', 'Animals', 'Antibodies, Monoclonal, Humanized', 'Breast', 'Breast Neoplasms', 'Cell Line, Tumor', 'Female', 'Heterocyclic Compounds, 1-Ring', 'Humans', 'Immunoconjugates', 'Indium Radioisotopes', 'Mice', 'Mice, Inbred BALB C', 'Models, Molecular', 'Receptor, ErbB-2', 'Tomography, Emission-Computed, Singl... | 22,519,915 | [['D02.113'], ['B01.050'], ['D12.776.124.486.485.114.224.060', 'D12.776.124.790.651.114.224.060', 'D12.776.377.715.548.114.224.200'], ['A01.236'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['D03.383'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.790.651.114.580', 'D1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
N/OFQ-NOP System and Airways. | Asthma is a heterogeneous chronic inflammatory disease of the airways. The most prevalent form is atopic asthma, which is initiated by the exposure to (inhaled) allergens. Intermittent attacks of breathlessness, airways hyperresponsiveness, wheezing, coughing, and resultant allergen-specific immune responses characteri... | ['Asthma', 'Humans', 'Inflammation', 'Opioid Peptides', 'Respiratory System', 'Th2 Cells'] | 30,725,285 | [['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.470'], ['D12.644.400.575', 'D12.776.631.650.575'], ['A04'], ['A11.118.637.555.567.550.500.400.905', 'A11.118.637.555.567.569.200.400.905', 'A11.118.637.555.567.569.500.400.905', 'A15.145... | ['Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nigella sativa protects against ischaemia/reperfusion injury in rat kidneys. | BACKGROUND: Renal ischaemia followed by reperfusion leads to acute renal failure in both native kidneys and renal allografts, which is a complex pathophysiologic process involving hypoxia and free radical (FR) damage. The oil of Nigella sativa (NSO) has been subjected to considerable pharmacological investigations that... | ['Animals', 'Blood Urea Nitrogen', 'Catalase', 'Disease Models, Animal', 'Glutathione Peroxidase', 'Kidney', 'Kidney Diseases', 'Male', 'Malondialdehyde', 'Nigella sativa', 'Nitric Oxide', 'Plant Preparations', 'Random Allocation', 'Rats', 'Rats, Wistar', 'Reperfusion Injury', 'Superoxide Dismutase'] | 18,211,980 | [['B01.050'], ['E01.370.225.124.100.115', 'E01.370.390.400.100', 'E05.200.124.100.115'], ['D08.811.682.732.332'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['D08.811.682.732.500'], ['A05.810.453'], ['C12.777.419', 'C13.351.968.419'], ['D02.047.700'], ['B01.650.940.800.575.912.250.836.750.518.750'], ['D01.339.387',... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
MEK inhibition enhances ABT-737-induced leukemia cell apoptosis via prevention of ERK-activated MCL-1 induction and modulation of MCL-1/BIM complex. | Recently, strategies for acute myeloid leukemia (AML) therapy have been developed that target anti-apoptotic BCL2 family members using BH3-mimetic drugs such as ABT-737. Though effective against BCL2 and BCL-X(L), ABT-737 poorly inhibits MCL-1. Here we report that, unexpectedly, ABT-737 induces activation of the extrac... | ['Animals', 'Antineoplastic Agents', 'Apoptosis', 'Apoptosis Regulatory Proteins', 'Bcl-2-Like Protein 11', 'Benzamides', 'Biphenyl Compounds', 'Cell Line, Tumor', 'Diphenylamine', 'Extracellular Signal-Regulated MAP Kinases', 'Humans', 'Leukemia, Myeloid, Acute', 'Membrane Proteins', 'Mice', 'Mice, Nude', 'Mitogen-Act... | 22,064,351 | [['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['D12.644.360.075', 'D12.776.476.075'], ['D12.644.360.075.323', 'D12.776.476.075.323', 'D12.776.543.116', 'D12.776.624.664.700.025'], ['D02.065.277', 'D02.241.223.100.100', 'D02.455.426.559.389.127.085'], ['D02.455.426.559.389.185'], ['A11.251.210.190', 'A11.251.8... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ethnicity and discordance in plasma HIV-1 RNA viral load and CD4+ lymphocyte count in a cohort of HIV-1-infected individuals. | BACKGROUND: Guidelines for commencing therapy for HIV infection have been based upon HIV-1 RNA and CD4 lymphocyte thresholds. The influence of confounding factors such as gender, ethnicity and co-infections is unproven.OBJECTIVES: To analyse ethnic discordance in plasma HIV-1 viral load (VL) and CD4+ count and its pote... | ['Adult', 'Africa South of the Sahara', 'African Continental Ancestry Group', 'CD4 Lymphocyte Count', 'Caribbean Region', 'Cohort Studies', 'Confounding Factors, Epidemiologic', 'Cross-Sectional Studies', 'Ethnic Groups', 'European Continental Ancestry Group', 'Female', 'HIV Infections', 'HIV-1', 'Humans', 'London', 'M... | 12,589,840 | [['M01.060.116'], ['Z01.058.290'], ['M01.686.508.100'], ['E01.370.225.500.195.107.595.500.150', 'E01.370.225.625.107.595.500.150', 'E05.200.500.195.107.595.500.150', 'E05.200.625.107.595.500.150', 'E05.242.195.107.595.500.150', 'G04.140.107.595.500.150', 'G09.188.105.595.500.150'], ['Z01.107.084'], ['E05.318.372.500.75... | ['Named Groups [M]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Clinical and arthrographic evaluation of the location of temporomandibular joint pain. | Two hundred five patients were prospectively examined for temporomandibular joint pain. Arthrograms were performed on 222 joints (188 unilateral and 17 bilateral). Pain in the ear occurred more frequently in arthrographically normal patients and in nonreducing meniscus patients compared with reducing meniscus patients.... | ['Arthrography', 'Cartilage, Articular', 'Facial Pain', 'Headache', 'Humans', 'Neck', 'Prospective Studies', 'Temporomandibular Joint Dysfunction Syndrome'] | 3,475,659 | [['E01.370.350.700.070'], ['A02.165.407.150', 'A02.835.583.192'], ['C23.888.592.612.330'], ['C23.888.592.612.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.598'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650', 'N06.850.520.450.500.750.650'], ['C05.500.607.221.897.897', 'C05.550.905.905', 'C05... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Contemporary Insertion of Central Venous Access Catheters in Pediatric Patients: A Retrospective Record Review Study of 538 Catheters in a Single Center. | OBJECTIVE: To analyze the rate of infections and complications after surgeon-performed, largely ultrasound-guided, central venous catheter (CVC) placement in a pediatric population and to identify patients at high risk of complications.METHODS: All children aged between 4 months and 19 years with a percutaneous CVC ins... | ['Adolescent', 'Adult', 'Catheter-Related Infections', 'Catheterization, Central Venous', 'Central Venous Catheters', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Male', 'Netherlands', 'Retrospective Studies', 'Young Adult'] | 27,740,892 | [['M01.060.057'], ['M01.060.116'], ['C01.195'], ['E02.148.167', 'E04.100.814.529.875', 'E04.502.382.875', 'E05.157.313'], ['E07.132.750.500'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['Z01.542.651'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', '... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Geographicals [Z]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Total Synthesis of (-)-Luminacin D. | A second-generation synthesis of (-)-luminacin D based on an early stage introduction of the trisubstituted epoxide group is reported, allowing access to the natural product in an improved yield and a reduced number of steps (5.4%, 17 steps vs 2.6%, 19 steps). A full account of the optimization work is provided, with t... | ['Alcohols', 'Benzaldehydes', 'Cyclization', 'Epoxy Compounds', 'Spiro Compounds', 'Stereoisomerism'] | 27,054,953 | [['D02.033'], ['D02.047.222'], ['G02.111.180', 'G02.607.133', 'G03.208'], ['D02.355.291.411'], ['D02.455.426.779', 'D04.711'], ['G02.607.445.682']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Gold nanoparticles as carriers for a synthetic Streptococcus pneumoniae type 14 conjugate vaccine. | AIMS: Coupling of capsular polysaccharides of pathogens to immunogenic protein carriers (conjugate vaccines) improves carbohydrate immune response. Our idea is to explore gold nanoclusters as carriers to prepare fully synthetic carbohydrate vaccines.MATERIALS & METHODS: Gold glyconanoparticles bearing a synthetic tetra... | ['Animals', 'Bacterial Capsules', 'Bacterial Vaccines', 'Carbohydrates', 'Drug Delivery Systems', 'Epitopes', 'Gold', 'Humans', 'Mice', 'Nanoparticles', 'Phagocytosis', 'Streptococcus pneumoniae', 'Vaccines, Conjugate'] | 22,630,149 | [['B01.050'], ['A20.186'], ['D20.215.894.135'], ['D09'], ['E02.319.300'], ['D23.050.550'], ['D01.268.556.322', 'D01.268.956.186', 'D01.552.544.322'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['J01.637.512.600'], ['G04.417.350', 'G09.188.665', 'G12.450.564.809', 'G12.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
The familial occurrence of brain tumors. | This is a report of two parent-child families which developed intracranial neoplasm. There is no known history of brain tumor in other family members. Two instances of familial brain tumors are reported which are different from those seen in phakomatosis. Family one had posterior fossa tumors including astrocytoma and ... | ['Adenoma', 'Adult', 'Astrocytoma', 'Brain Neoplasms', 'Child', 'Endodermal Sinus Tumor', 'Fatal Outcome', 'Female', 'Hemangioblastoma', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Pituitary Neoplasms', 'Tomography, X-Ray Computed'] | 9,177,089 | [['C04.557.470.035'], ['M01.060.116'], ['C04.557.465.625.600.380.080', 'C04.557.470.670.380.080', 'C04.557.580.625.600.380.080'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['M01.060.406'], ['C04.557.465.510.350'], ['E05.318.308.985.550.325', 'N01.224.935.698.201', 'N06.850.505.400.975.550.325', 'N0... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Randomized dose-escalation designs for drug combination cancer trials with immunotherapy. | This work considers Phase I cancer dual-agent dose-escalation clinical trials in which one of the compounds is an immunotherapy. The distinguishing feature of trials considered is that the dose of one agent, referred to as a standard of care, is fixed and another agent is dose-escalated. Conventionally, the goal of a P... | ['Antineoplastic Combined Chemotherapy Protocols', 'Bayes Theorem', 'Clinical Trials, Phase I as Topic', 'Computer Simulation', 'Dose-Response Relationship, Drug', 'Humans', 'Immunotherapy', 'Maximum Tolerated Dose', 'Models, Statistical', 'Neoplasms', 'Randomized Controlled Trials as Topic', 'Research Design'] | 30,352,007 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['E05.318.372.250.250.200', 'N05.715.360.330.250.250.200', 'N06.850.520.450.250.250.200'], ['L01.224.160'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.649.313.988.400... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
T cell-depleted unrelated donor bone marrow transplantation for acute myeloid leukemia. | The outcome for 39 patients with acute myeloid leukemia (AML) in remission who had CAMPATH 1M T cell-depleted unrelated donor bone marrow transplantations (BMTs) is described. Conditioning was mainly with cyclophosphamide (120 mg/kg) and total body irradiation (TBI) (14.4 Gy), but 5 patients received busulfan in place ... | ['Acute Disease', 'Adolescent', 'Adult', 'Bone Marrow Transplantation', 'Child', 'Child, Preschool', 'Female', 'Graft Survival', 'Graft vs Host Disease', 'Histocompatibility Testing', 'Humans', 'Infant', 'Leukemia, Myeloid', 'Lymphocyte Depletion', 'Male', 'T-Lymphocytes', 'Transplantation, Homologous'] | 11,128,816 | [['C23.550.291.125'], ['M01.060.057'], ['M01.060.116'], ['E02.095.147.725.040', 'E04.936.580.040'], ['M01.060.406'], ['M01.060.406.448'], ['G12.875.545.340'], ['C20.452'], ['E01.370.225.812.385', 'E05.200.812.385', 'E05.478.594.385'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C04.557.337.539']... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
An Integrated Approach to Determining Rural Tourist Satisfaction Factors Using the IPA and Conjoint Analysis. | Rural tourists satisfaction has a pivotal role in the development of sustainable rural tourism. As a method of identifying critical satisfaction factors, an importance and performance analysis (IPA) technique has attracted growing interest from academics due to it being able to deliver the importance and performance of... | ['Adult', 'China', 'Consumer Behavior', 'Female', 'Humans', 'Male', 'Middle Aged', 'Personal Satisfaction', 'Travel'] | 31,614,640 | [['M01.060.116'], ['Z01.252.474.164'], ['F01.145.236'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.145.677'], ['I03.883']] | ['Named Groups [M]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 |
5-Hydroxytryptamine-mediated inhibition of protein synthesis in rabbit reticulocyte lysate cell-free system. | Addition of 5-hydroxytryptamine (5-HT) to initiation dependent rabbit reticulocyte lysate cell-free system caused marked reductions in endogenous mRNA- and poly(U)-directed protein synthesis. Comparison of the effects on protein synthesis of 5-HT with known inhibitors of initiation (aurintricarboxylic acid and polyinos... | ['Adenosine Triphosphate', 'Amino Acids', 'Animals', 'Aurintricarboxylic Acid', 'Cell-Free System', 'Poly I', 'Polyribonucleotides', 'Protein Biosynthesis', 'RNA, Messenger', 'Rabbits', 'Reticulocytes', 'Serotonin', 'Temperature', 'Time Factors', 'Tryptophan'] | 7,403,658 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D12.125'], ['B01.050'], ['D02.241.223.268.070'], ['A11.284.835.168'], ['D13.695.578.550.650'], ['D13.695.578.550'], ['G02.111.660.871', 'G03.734.871', 'G05.297.670'], ['D13.444.735.544'], ['B01.050.150.900.649.313.968.700'], ['A11.118.290... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Cytogenetic and molecular genetic diagnostics of Rett syndrome in children]. | Rett syndrome in 32 children (31 girls and 1 boy) was diagnosed according to International association on Rett syndrome. The phenomenon of the presence of special type of late-replicating chromosome X (type C) was revealed. This phenomenon may be recommended as a diagnostic test for both preclinical periods of developm... | ['Child', 'Child, Preschool', 'DNA Probes', 'DNA Replication', 'Female', 'Genetic Markers', 'Humans', 'In Situ Hybridization, Fluorescence', 'Karyotyping', 'Male', 'Pedigree', 'Rett Syndrome', 'Sex Chromosome Aberrations', 'X Chromosome'] | 9,606,901 | [['M01.060.406'], ['M01.060.406.448'], ['D13.444.600.223', 'D27.505.259.750.600.223', 'D27.720.470.530.600.223'], ['G02.111.225', 'G05.226'], ['D23.101.387', 'G05.695.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.620.670.325.350', 'E01.370.225.750.600.670.325.350', 'E05.200.500.620.670.325.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The potential roles of cell migration and extra-cellular matrix interactions in Dupuytren's disease progression and recurrence. | Dupuytren's disease is a pathological condition of the palmar fascia characterized by the formation of contractile disease cords that result in permanent finger contracture. This condition is believed to progress from a myofibroblast-rich nodule in the early clinical stages of the disease to a contractile disease cord ... | ['Animals', 'Cell Movement', 'Disease Progression', 'Dupuytren Contracture', 'Extracellular Matrix', 'Fascia', 'Fibroblasts', 'Humans', 'Models, Biological', 'Myoblasts', 'Recurrence'] | 19,896,280 | [['B01.050'], ['G04.198', 'G07.568.500.180'], ['C23.550.291.656'], ['C04.557.450.565.590.340.173', 'C05.651.197.270', 'C17.300.270'], ['A11.284.295.310'], ['A02.340', 'A10.165.425'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['A11.872.620'], ['C23.550.291.937']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification and Functional Characterization of Two Sigma Glutathione S-Transferase Genes From Bird Cherry-Oat Aphid (Hemiptera: Aphididae). | The bird cherry-oat aphid, Rhopalosiphum padi (L.), is an insect pest that persistently attacks wheat crops worldwide. Glutathione S-transferases (GSTs) are important detoxification enzymes that play roles in insecticide resistance. In this study, we identified two GST genes (RpGSTS1 and RpGSTS2) from R. padi. Phylogen... | ['Amino Acid Sequence', 'Animals', 'Aphids', 'Glutathione Transferase'] | 30,371,799 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.500.131.617.412.165'], ['D08.811.913.225.500']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The biochemical anatomy of cortical inhibitory synapses. | Classical electron microscopic studies of the mammalian brain revealed two major classes of synapses, distinguished by the presence of a large postsynaptic density (PSD) exclusively at type 1, excitatory synapses. Biochemical studies of the PSD have established the paradigm of the synapse as a complex signal-processing... | ['Animals', 'Cerebral Cortex', 'HEK293 Cells', 'Humans', 'Mass Spectrometry', 'Mice', 'Mice, Transgenic', 'Nerve Tissue Proteins', 'Neural Inhibition', 'Protein Transport', 'Receptors, GABA-A', 'Synapses', 'Xenopus'] | 22,768,092 | [['B01.050'], ['A08.186.211.200.885.287.500'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.566'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.136.500', 'B01.050.150.900.649.313.992.635.505.500.800'], ['D12.776.631'], ['G07.265.755', 'G11.561.616'], [... | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
X-linked genetic factors regulate hematopoietic stem-cell kinetics in females. | X inactivation makes females mosaics for 2 cell populations, usually with an approximate 1:1 distribution. Skewing of this distribution in peripheral blood cells is more common among elderly women. The depletion of hematopoietic stem cells followed by random differentiation may explain the acquired skewing with age. Ho... | ['Aged', 'Aged, 80 and over', 'Cell Differentiation', 'Dosage Compensation, Genetic', 'Female', 'Genetic Linkage', 'Hematopoietic Stem Cells', 'Humans', 'Kinetics', 'Polymerase Chain Reaction', 'X Chromosome'] | 10,733,522 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['G04.152'], ['G05.308.203.249'], ['G05.348'], ['A11.148.378', 'A11.872.378', 'A15.378.316.378'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['E05.393.620.500'], ['A11.284.187.865.982', 'G05.360.162.865.982']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Analysis of the osteoinductive capacity and angiogenicity of an in vitro generated extracellular matrix. | In this study, the osteoinductive potential of an in vitro generated extracellular matrix (ECM) deposited by marrow stromal cells seeded onto titanium fiber mesh scaffolds and cultured in a flow perfusion bioreactor was investigated. Culture periods of 8, 12, and 16 days were selected to allow for different amounts of ... | ['Animals', 'Biocompatible Materials', 'Bone Marrow Cells', 'Extracellular Matrix', 'Implants, Experimental', 'Male', 'Materials Testing', 'Neovascularization, Physiologic', 'Osteogenesis', 'Rats', 'Rats, Inbred F344', 'Stromal Cells', 'Tissue Engineering', 'Tissue Scaffolds', 'Titanium'] | 18,286,641 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['A11.148', 'A15.378.316'], ['A11.284.295.310'], ['E07.695.340'], ['E05.570'], ['G09.330.630'], ['G07.345.500.325.377.625.050.500.729', 'G11.427.578.050.500.729'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.200', 'B01.050.150.9... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Long-Term Cognitive and Behavioral Outcomes following Resolution of Sleep Disordered Breathing in Preschool Children. | This study aimed to determine the long term effects of resolution of SDB in preschool children, either following treatment or spontaneous recovery, on cognition and behavior. Children diagnosed with SDB at 3-5y (N = 35) and non-snoring controls (N = 25), underwent repeat polysomnography (PSG) and cognitive and behavior... | ['Child Behavior', 'Child, Preschool', 'Cognition', 'Female', 'Humans', 'Longitudinal Studies', 'Male', 'Polysomnography', 'Sleep Apnea Syndromes', 'Sleep Deprivation', 'Snoring'] | 26,418,065 | [['F01.145.179'], ['M01.060.406.448'], ['F02.463.188'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['E01.370.520.625'], ['C08.618.085.852', 'C10.886.425.800.750'], ['C10.886.425.175', 'C23.888.592.796.772', 'F02.830.855.671... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Phosphatase SHP-1 promotes TLR- and RIG-I-activated production of type I interferon by inhibiting the kinase IRAK1. | Unbalanced production of proinflammatory cytokines and type I interferons in immune responses may lead to immunopathology; thus, the mechanisms that ensure the beneficial production of proinflammatory cytokines and type I interferons are of particular importance. Here we demonstrate that the phosphatase SHP-1 negativel... | ['Animals', 'Catalytic Domain', 'Cytokines', 'Homeostasis', 'Immunity, Innate', 'Interferon Regulatory Factor-1', 'Interferon Type I', 'Interleukin-1 Receptor-Associated Kinases', 'Macrophages, Peritoneal', 'Membrane Proteins', 'Mice', 'Mice, Inbred C57BL', 'Mitogen-Activated Protein Kinase Kinases', 'NF-kappa B', 'Ner... | 18,391,954 | [['B01.050'], ['G02.111.570.120.704', 'G02.111.570.820.709.275.750.188'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['G07.410'], ['G12.450.564'], ['D12.644.360.024.302.124', 'D12.776.157.057.050.124', 'D12.776.260.108.374', 'D12.776.260.504.124', 'D12.776.476.024.385.124', 'D12.776.930.127.374', 'D12.776.9... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Parental perspectives of diabetes management in Alabama public schools. | OBJECTIVES: The purpose of this study was to assess parental perceptions of the current state of care for children with diabetes in the Alabama public school system, identify existing disparities, and determine what resources would most improve diabetes management in this setting. There is a significant need for such i... | ['Alabama', 'Child', 'Diabetes Mellitus, Type 1', 'Disease Management', 'Female', 'Healthcare Disparities', 'Humans', 'Logistic Models', 'Male', 'School Health Services', 'Statistics, Nonparametric', 'Surveys and Questionnaires'] | 23,558,417 | [['Z01.107.567.875.075.100', 'Z01.107.567.875.750.100'], ['M01.060.406'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['N04.590.607'], ['N04.590.374.380', 'N05.300.493'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', 'E05.599.835.87... | ['Geographicals [Z]', 'Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Clinical utility of intraprocedural three-dimensional integrated image guided transcatheter aortic valve implantation using novel automated computed tomography software: A single-center preliminary experience. | OBJECTIVES: Novel automated computed tomography (CT) software (Valve ASSIST 2) has been developed for transcatheter aortic valve implantation (TAVI), which not only provides three-dimensional (3D) reconstruction of multidetector (MD) CT images, but also enables intraprocedural real-time fusion of fluoroscopic and MDCT ... | ['Aged', 'Aged, 80 and over', 'Aortic Valve', 'Aortic Valve Stenosis', 'Calcinosis', 'Female', 'Fluoroscopy', 'Heart Valve Prosthesis', 'Humans', 'Imaging, Three-Dimensional', 'Male', 'Multidetector Computed Tomography', 'Multimodal Imaging', 'Predictive Value of Tests', 'Preliminary Data', 'Prosthesis Design', 'Severi... | 30,408,327 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['A07.541.510.110'], ['C14.280.484.048.750', 'C14.280.955.249'], ['C18.452.174.130'], ['E01.370.350.700.225'], ['E07.695.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.400', 'L01.224.308.410'], ['E01.370.350.350.810.800.500', 'E01.370.350.600.350.700... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Education in palliative care: a qualitative evaluation of the present state and the needs of general practitioners and community nurses. | A questionnaire survey was carried out of all general practitioners, community hospital nurses and community nurses working in Worcester Health District in the west of England, to assess the present state and future needs of their education in palliative care. The overall response rate of the survey was 72%. The respon... | ['Community Health Nursing', 'Hospitals, Community', 'Humans', 'Nursing Staff, Hospital', 'Physicians, Family', 'Surveys and Questionnaires', 'Terminal Care'] | 7,711,971 | [['H02.478.676.150', 'N02.421.143.150'], ['N02.278.421.306'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.526.485.680.490', 'M01.526.485.740.523', 'N02.360.680.490', 'N02.360.740.523'], ['M01.526.485.810.770', 'N02.360.810.770'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.980'], ['E02.760.90... | ['Disciplines and Occupations [H]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Chinese midwives' experience of providing continuity of care to labouring women. | OBJECTIVE: to explore and describe Chinese midwives' experience of providing one-to-one continuity of care to labouring women.DESIGN: a qualitative study using a phenomenological approach. Data were collected using open-ended, tape-recorded interviews. The analysis of the transcribed texts included searching for themes... | ['Adaptation, Psychological', 'Attitude of Health Personnel', 'China', 'Continuity of Patient Care', 'Female', 'Humans', 'Midwifery', "Nurse's Role", 'Nurse-Patient Relations', 'Parturition', 'Personnel Staffing and Scheduling', 'Pregnancy', 'Qualitative Research'] | 19,700,229 | [['F01.058'], ['F01.100.050', 'N05.300.100'], ['Z01.252.474.164'], ['E02.760.169', 'N02.421.585.169', 'N04.590.233.727.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.478.676.416'], ['F01.829.316.616.625.450', 'N05.300.100.337'], ['F01.829.401.650.600', 'N05.300.660.560'], ['G08.686.784.769.490'], ['I03.9... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Intramembrane electrostatic interactions destabilize lipid vesicles. | Membrane stability is of central concern in many biology and biotechnology processes. It has been suggested that intramembrane electrostatic interactions play a key role in membrane stability. However, due primarily to a lack of supporting experimental evidence, they are not commonly considered in mechanical analyses o... | ['Biophysical Phenomena', 'Biophysics', 'Electrolytes', 'Glucose', 'Ions', 'Lipid Metabolism', 'Membranes, Artificial', 'Models, Theoretical', 'Phosphatidic Acids', 'Phosphatidylglycerols', 'Potassium Chloride', 'Salts', 'Static Electricity'] | 12,324,419 | [['G01.154'], ['H01.158.344', 'H01.671.100'], ['D01.248'], ['D09.947.875.359.448'], ['D01.248.497'], ['G03.458'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['E05.599'], ['D10.570.755.375.760'], ['D10.570.755.375.760.400.885'], ['D01.210.450.150.750', 'D01.745.625'], ['D01.786'], ['G01.358.500.249.820']] | ['Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
A new species of Raspy cricket genus <i>Gryllacris</i> (Orthoptera: Gryllacrididae) from Central India. | Gryllacris durgensis sp. nov. is described from the Durg district, Chhattisgarh, India. The detailed morphological characters of adult male, female and nymph are provided. | ['Animal Distribution', 'Animal Structures', 'Animals', 'Body Size', 'Female', 'Gryllidae', 'India', 'Male', 'Organ Size', 'Orthoptera'] | 29,245,575 | [['F01.145.113.069', 'G16.049'], ['A13'], ['B01.050'], ['E01.370.600.115.100.160', 'E05.041.124.160', 'G07.100.100.160', 'G07.345.249.314'], ['B01.050.500.131.617.678.410'], ['Z01.252.245.393'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['B01.050.500.131.617.678']] | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
A comparison of two bipolar exercise electrocardiographic leads to lead V5. | ST-segment depression and slope were compared in three lead systems (V5, CC5, and CM5) and in two groups of patients using both visual analysis of electrocardiographic paper and computerized techniques. Bipolar lead CC5 was found to be comparable to lead V5 when visual analysis of electrocardiographic recordings was ut... | ['Adult', 'Computers', 'Computers, Analog', 'Electrocardiography', 'Exercise Test', 'Humans', 'Male', 'Middle Aged'] | 975,977 | [['M01.060.116'], ['L01.224.230.260'], ['L01.224.230.260.230'], ['E01.370.370.380.240', 'E01.370.405.240'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Named Groups [M]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
The influence of desensitizing dentifrices on pain induced by in-office bleaching. | The purpose of this study was to evaluate whether the use of desensitizing dentifrices used 15 days prior to and after in-office tooth bleaching could eliminate or reduce tooth sensitivity. After institutional review board approval and informed consent, 45 subjects were selected and divided into 3 groups according to t... | ['Adolescent', 'Adult', 'Color', 'Complex Mixtures', 'Dentifrices', 'Dentin Desensitizing Agents', 'Dentin Sensitivity', 'Drug Combinations', 'Female', 'Fluorides', 'Humans', 'Male', 'Nitrates', 'Phosphates', 'Potassium Compounds', 'Premedication', 'Random Allocation', 'Silicic Acid', 'Statistics, Nonparametric', 'Time... | 24,346,050 | [['M01.060.057'], ['M01.060.116'], ['G01.590.540.199'], ['D20'], ['D25.376', 'D27.720.269.380', 'J01.637.051.376'], ['D27.505.696.663.850.014.640', 'D27.505.954.427.040.437'], ['C07.793.266'], ['D26.310'], ['D01.248.497.158.380', 'D01.303.350.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.248.497.158.606... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Effects of basilar membrane arch and radial tension on the travelling wave in gerbil cochlea. | The basilar membrane velocity of gerbil cochlea showed discrepancy between theoretical model and experimental measurements. We hypothesize that the reasons of such discrepancies are due to the arch towards the scala tympani and radial tension present in the basilar membrane of the gerbil cochlea. The arch changes the b... | ['Acoustic Stimulation', 'Animals', 'Basilar Membrane', 'Biomechanical Phenomena', 'Cochlea', 'Elasticity', 'Gerbillinae', 'Hearing', 'Models, Animal', 'Models, Biological', 'Motion', 'Time Factors'] | 26,070,425 | [['E02.037', 'E02.190.888.030', 'E05.723.136'], ['B01.050'], ['A09.246.300.246.125', 'A10.615.179.124'], ['G01.154.090', 'G01.374.089'], ['A09.246.300.246'], ['G01.374.590'], ['B01.050.150.900.649.313.992.635.300'], ['F02.830.816.263', 'G07.888.500', 'G11.561.790.263'], ['E05.598'], ['E05.599.395'], ['G01.482'], ['G01.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Digital processing and densitometry of tomograms in central lung cancer]. | Additional information on an x-ray picture of peribronchial changes in tumorous and non-tumorous lesions of the lungs were obtained in 54 patients (40 with bronchogenic, mostly central cancer and 14 with chronic inflammatory diseases) in order to study roentgenological symptomatology before and after computerized proce... | ['Humans', 'Image Processing, Computer-Assisted', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Tomography, X-Ray Computed'] | 2,270,660 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.116.630'], ['E01.370.350.350.810', 'E01.370.350.600.350.700.810', 'E01.370.350.700.700.810', 'E01.370.350.700.810.810', 'E01.370.350.825.810.810']] | ['Organisms [B]', 'Information Science [L]', 'Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 |
[Management of hemangioma in the infant]. | Foster child hemangioma management depends on its usual spontaneously regressive evolution as it is a transient and benign vascular tumor like lesion. Most of the time clinical follow up is the only management. Investigations are indicated if treatment is needed (for decision and follow up) concerning only hemangiomas ... | ['Ear Neoplasms', 'Eyelid Neoplasms', 'Follow-Up Studies', 'Hemangioma', 'Humans', 'Infant, Newborn', 'Lip Neoplasms', 'Liver Neoplasms', 'Nose Neoplasms', 'Prognosis'] | 1,588,231 | [['C04.588.443.665.312', 'C09.218.334', 'C09.647.312'], ['C04.588.443.392.500', 'C11.319.421', 'C11.338.526'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C04.557.645.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C04.588.443.591.550', 'C0... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Spermatogenesis of a marine snail, Littorina sitkana. | The fine structure of the spermatogonium, spermatocyte and spermatid of a marine snail, Littorina sitkana is described. The ring centriole (annulus) is formed from the distal centriole and it migrates to the base of the mitochondrial region where it lies in a joint-like structure which is formed by an area of invaginat... | ['Acrosome', 'Animals', 'Cell Nucleus', 'Chromatin', 'Male', 'Snails', 'Spermatids', 'Spermatocytes', 'Spermatogenesis', 'Spermatogonia', 'Spermatozoa'] | 963,725 | [['A05.360.490.890.820.100', 'A11.284.430.214.190.875.190.550.040', 'A11.497.760.400.100'], ['B01.050'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.430.106.279.345.190.160.180', 'D12.776.664.224', 'G05.360.160.180'], ['B01.050.500.644.400.750'], ['A05.360.490.890.860', 'A11.497.760.600'], ['A05.360.4... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Structured dietary intervention to facilitate weight loss after bariatric surgery: A randomized, controlled pilot study. | OBJECTIVE: To evaluate the potential utility of a structured dietary intervention to assist bariatric surgery patients with weight management.METHODS: Participants who underwent Roux-en-Y gastric bypass surgery 1 year previously were randomly assigned to a structured dietary intervention incorporating portion-controlle... | ['Adult', 'Bariatric Surgery', 'Diet', 'Female', 'Food Preferences', 'Health Education', 'Humans', 'Life Style', 'Male', 'Middle Aged', 'Obesity, Morbid', 'Pilot Projects', 'Research Design', 'Weight Loss'] | 27,466,039 | [['M01.060.116'], ['E02.650.500.062', 'E04.062'], ['G07.203.650.240'], ['F01.145.407.516', 'G07.203.650.353.516'], ['I02.233.332', 'N02.421.726.407'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.458'], ['M01.060.116.630'], ['C18.654.726.500.700', 'C23.888.144.699.500.500', 'E01.370.600.115.100.160.120.69... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 1 | 0 |
Effect of hyperinsulinaemia on the function of the pituitary-adrenal axis in healthy man. | OBJECTIVE: Circulating insulin levels in themselves have been reported to influence the counter-regulatory hormone response to hypoglycaemia in man. The effect of insulin on a specific aspect of this response was examined during euglycaemia by stimulating the pituitary-adrenal axis with human corticotrophin-releasing h... | ['Adrenocorticotropic Hormone', 'Adult', 'Blood Glucose', 'Corticotropin-Releasing Hormone', 'Humans', 'Hydrocortisone', 'Insulin', 'Male', 'Pituitary-Adrenal System', 'Stimulation, Chemical'] | 8,187,315 | [['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['M01.060.116'], ['D09.947.875.359.448.500'], ['D06.472.699.327.740.140', 'D12.644.400.400.740.140', 'D12.644.548.365.7... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Phenotypic variability in familial combined pituitary hormone deficiency caused by a PROP1 gene mutation resulting in the substitution of Arg-->Cys at codon 120 (R120C). | As pituitary function depends on the integrity of the hypothalamic-pituitary axis, any defect in the development and organogenesis of this gland may account for a form of combined pituitary hormone deficiency (CPHD). A mutation in a novel, tissue-specific, paired-like homeodomain transcription factor, termed Prophet of... | ['Adrenocorticotropic Hormone', 'Amino Acid Substitution', 'Child', 'Child, Preschool', 'Codon', 'Female', 'Homeodomain Proteins', 'Humans', 'Infant', 'Male', 'Mutation', 'Pedigree', 'Phenotype', 'Pituitary Hormones', 'Transcription Factors'] | 9,768,691 | [['D06.472.699.327.935.531.500', 'D06.472.699.631.525.600.531.500', 'D12.644.400.400.935.531.500', 'D12.644.548.365.935.531.500', 'D12.644.548.691.525.690.531.500', 'D12.776.631.650.405.935.531.500'], ['E05.393.420.601.035', 'G05.558.109'], ['M01.060.406'], ['M01.060.406.448'], ['D13.444.735.544.355', 'G05.360.335.355'... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Endoscopic third ventriculostomy for chronic hydrocephalus after tuberculous meningitis. | BACKGROUND: Cerebrospinal fluid diversion procedures are indicated in patients with hydrocephalus after tuberculous meningitis (TBM). We present 2 patients with hydrocephalus after TBM who were successfully treated with endoscopic third ventriculostomy (ETV).METHODS: Two patients had been diagnosed with hydrocephalus a... | ['Adult', 'Chronic Disease', 'Endoscopy', 'Female', 'Follow-Up Studies', 'Humans', 'Hydrocephalus', 'Male', 'Middle Aged', 'Postoperative Complications', 'Third Ventricle', 'Tomography, X-Ray Computed', 'Treatment Outcome', 'Tuberculosis, Meningeal', 'Ventriculoperitoneal Shunt', 'Ventriculostomy'] | 15,639,516 | [['M01.060.116'], ['C23.550.291.500'], ['E01.370.388.250', 'E04.502.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.602'], ['M01.060.116.630'], ['C23.550.767'], ['A08.186.211.140.840'], ['E01.370.350.350.810... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Footprint-free human induced pluripotent stem cells from articular cartilage with redifferentiation capacity: a first step toward a clinical-grade cell source. | Human induced pluripotent stem cells (iPSCs) are potential cell sources for regenerative medicine; however, clinical applications of iPSCs are restricted because of undesired genomic modifications associated with most reprogramming protocols. We show, for the first time, that chondrocytes from autologous chondrocyte im... | ['Cartilage', 'Cell Dedifferentiation', 'Cells, Cultured', 'Chondrocytes', 'Humans', 'Induced Pluripotent Stem Cells', 'Mesenchymal Stem Cells'] | 24,604,283 | [['A02.165', 'A10.165.382'], ['G04.148'], ['A11.251'], ['A11.329.171'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.872.040.500', 'A11.872.700.500'], ['A11.329.830.500', 'A11.872.590.500']] | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular basis of the synergistic production of IL-1 receptor antagonist by human neutrophils stimulated with IL-4 and IL-10. | In this study, we report that the release of IL-1 receptor antagonist (IL-1ra) from IL-4-stimulated neutrophils is markedly enhanced in the presence of IL-10. We also show that up-regulation of IL-1ra release by IL-10 in IL-4-stimulated neutrophils takes place through IL-1ra mRNA stabilization and enhancement of IL-1ra... | ['1-(5-Isoquinolinesulfonyl)-2-Methylpiperazine', 'DNA-Binding Proteins', 'Drug Synergism', 'Humans', 'Interleukin 1 Receptor Antagonist Protein', 'Interleukin-10', 'Interleukin-4', 'Lipopolysaccharides', 'Neutrophils', 'Phosphorylation', 'RNA, Messenger', 'Receptors, Interleukin', 'Receptors, Interleukin-10', 'STAT3 T... | 12,356,680 | [['D02.886.590.700.545', 'D03.383.606.527', 'D03.633.100.531.400'], ['D12.776.260'], ['G07.690.773.968.477'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.460', 'D12.776.467.374.460', 'D23.529.374.460'], ['D12.644.276.374.465.510', 'D12.776.467.374.465.510', 'D23.529.374.465.510'], ['D12.644.276.3... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Introducing care management to Brazil's alcohol and substance use disorder population. | Brazil has a sizable alcohol and substance use disorder (ASUD) population, yet there are considerable gaps in treatment access and retention. ASUD, a chronic medical condition, is highly comorbid with medical and behavioral health disorders. This indicates a need for more targeted interventions in order to achieve heal... | ['Alcoholism', 'Brazil', 'Chronic Disease', 'Delivery of Health Care, Integrated', 'Humans', 'Medication Adherence', 'Mental Health Services', 'Patient Care Management', 'Substance-Related Disorders'] | 29,267,603 | [['C25.775.100.250', 'F03.900.100.350'], ['Z01.107.757.176'], ['C23.550.291.500'], ['N04.590.374.142', 'N05.300.262'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.500.600.500', 'F01.145.488.887.500.600.500', 'N05.300.150.800.500.600.500'], ['F04.408', 'N02.421.461'], ['N04.590'], ['C25.775', 'F03... | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Geographicals [Z]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Enhancing effect of quercetin on 3-methylcholanthrene carcinogenesis in C57Bl/6 mice. | We investigated the effect of quercetin on 3-methylcholanthrene (MCA) carcinogenesis in C57Bl/6 mice. We found that quercetin itself was not carcinogenic when administered i.m., even at a dose of 20 mg, throughout an observation period of 420 days. An i.m. administration of various doses of quercetin admixed with 1.0 m... | ['Animals', 'Bone Marrow Cells', 'Cocarcinogenesis', 'Female', 'Flavonoids', 'Lung Neoplasms', 'Methylcholanthrene', 'Mice', 'Mice, Inbred C57BL', 'Neoplasms, Experimental', 'Quercetin', 'Sister Chromatid Exchange'] | 4,047,255 | [['B01.050'], ['A11.148', 'A15.378.316'], ['C04.697.098.875', 'C23.550.727.098.750'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['D02.455.426.559.847.149.500', 'D04.615.149.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A variant of estrogen receptor-{alpha}, hER-{alpha}36: transduction of estrogen- and antiestrogen-dependent membrane-initiated mitogenic signaling. | The status of the 66-kDa human estrogen receptor-alpha (hER-alpha66) is a critical determinant in the assessment of the prognosis and in the design of treatment strategies of human breast cancer. Recently, we cloned the cDNA of an alternatively spliced variant of hER-alpha66, termed hER-alpha36; the predicted protein l... | ['Alternative Splicing', 'Breast Neoplasms', 'Cell Line', 'Cell Membrane', 'Cell Proliferation', 'Estradiol', 'Estrogen Receptor Modulators', 'Estrogen Receptor alpha', 'Estrogen Receptor beta', 'Female', 'Humans', 'Mitogen-Activated Protein Kinases', 'Protein Isoforms', 'Signal Transduction'] | 16,754,886 | [['G02.111.760.700.100', 'G03.839.700.100', 'G05.308.700.700.100'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210'], ['A11.284.149'], ['G04.161.750', 'G07.345.249.410.750'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['D06.347.360', 'D27.505.696.399.450.360'], ['D12.776.826.750.350.174'], ['D12.776.826... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assessment of Label-Free Quantification in Discovery Proteomics and Impact of Technological Factors and Natural Variability of Protein Abundance. | We evaluated the state of label-free discovery proteomics focusing especially on technological contributions and contributions of naturally occurring differences in protein abundance to the intersample variability in protein abundance estimates in this highly peptide-centric technology. First, the performance of popula... | ['Arabidopsis', 'Arabidopsis Proteins', 'Gene Expression Regulation, Plant', 'Peptides', 'Protein Folding', 'Proteome', 'Proteomics', 'Software', 'Tandem Mass Spectrometry'] | 28,217,993 | [['B01.650.940.800.575.912.250.157.100'], ['D12.776.765.149'], ['G05.308.375'], ['D12.644'], ['G01.154.651', 'G02.111.688'], ['D12.776.817'], ['H01.158.201.843', 'H01.158.273.180.350.700', 'H01.158.273.343.350.700', 'H01.181.122.738'], ['L01.224.900'], ['E05.196.566.880']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Sternocleidomastoid pseudotumor and congenital muscular torticollis in infants: a prospective study of 510 cases. | OBJECTIVES: Congenital muscular torticollis is a common and controversial condition in infancy. We studied prospectively a group of infants with clearly defined sternomastoid tumor treated with a well-defined protocol.STUDY DESIGN: A total of 510 cases of sternomastoid tumor in infants over a 10-year period were studie... | ['Diagnosis, Differential', 'Female', 'Follow-Up Studies', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Muscle Neoplasms', 'Neck Muscles', 'Physical Therapy Modalities', 'Prognosis', 'Risk Factors', 'Rotation', 'Torticollis'] | 10,356,139 | [['E01.171'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['C04.588.839.500', 'C05.651.494'], ['A02.633.567.650'], ['E02.779', 'E02.831.535'], ['E01.789'], ['E05.318.740.600.800.725', 'N... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Congenital dyserythropoietic anaemia with novel intra-erythroblastic and intra-erythrocytic inclusions. | A hitherto undescribed form of congenital dyserythropoietic anaemia is reported. The patient was severely anaemic and hydropic at birth and is now 8 years old. She has a moderate normochromic normocytic anaemia. HbF level of 50%, reticulocyte count of 5-12% and hyperbilirubinaemia. Bone marrow smears showed intense nor... | ['Anemia, Dyserythropoietic, Congenital', 'Bone Marrow', 'Child', 'Endoplasmic Reticulum', 'Erythroblasts', 'Erythrocytes', 'Female', 'Golgi Apparatus', 'Humans', 'Inclusion Bodies', 'Intracellular Membranes', 'Microscopy, Electron'] | 1,659,863 | [['C15.378.071.141.150.095', 'C16.320.070.095'], ['A15.382.216'], ['M01.060.406'], ['A11.284.430.214.190.875.248'], ['A11.148.378.590.837.250.200', 'A11.443.240.497.200', 'A15.378.316.378.590.837.250.200'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['A11.284.430.214.190.875.336'], ['B01.050.150.900.649.313.988... | ['Diseases [C]', 'Anatomy [A]', 'Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Do patients with suspected heart failure and preserved left ventricular systolic function suffer from "diastolic heart failure" or from misdiagnosis? A prospective descriptive study. | OBJECTIVES: To characterise the clinical features of patients with suspected heart failure but preserved left ventricular systolic function to determine if they have other potential causes for their symptoms rather than being diagnosed with "diastolic heart failure."DESIGN: Prospective descriptive study.SETTING: Outpat... | ['Angina Pectoris', 'Body Mass Index', 'Cardiac Output, Low', 'Diagnosis, Differential', 'Diagnostic Errors', 'Dyspnea', 'Edema', 'Electrocardiography', 'Female', 'Forced Expiratory Volume', 'Humans', 'Male', 'Middle Aged', 'Myocardial Infarction', 'Obesity', 'Prospective Studies', 'Respiration Disorders', 'Ventricular... | 10,903,655 | [['C14.280.647.187', 'C14.907.585.187', 'C23.888.592.612.233.500'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C14.280.148', 'C23.888.192'], ['E01.171'], ['E01.354', 'N02.421.450.280'], ['C08.618.326', 'C23.888.852.371'], ['C23.888.277'], ['E01.370.370.380.240', 'E01... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Single-walled carbon nanotubes functionalized with sodium hyaluronate enhance bone mineralization. | The aim of this study was to evaluate the effects of sodium hyaluronate (HY), single-walled carbon nanotubes (SWCNTs) and HY-functionalized SWCNTs (HY-SWCNTs) on the behavior of primary osteoblasts, as well as to investigate the deposition of inorganic crystals on titanium surfaces coated with these biocomposites. Prim... | ['Animals', 'Apoptosis', 'Bone Morphogenetic Protein 2', 'Bone Morphogenetic Protein 4', 'Calcification, Physiologic', 'Cell Survival', 'Coated Materials, Biocompatible', 'Collagen Type I', 'Collagen Type III', 'Hyaluronic Acid', 'Male', 'Microscopy, Electron, Scanning', 'Nanotubes, Carbon', 'Organometallic Compounds',... | 26,648,087 | [['B01.050'], ['G04.146.954.035'], ['D12.644.276.954.200.200', 'D12.776.467.942.200.200', 'D23.529.942.200.200'], ['D12.644.276.954.200.400', 'D12.776.467.942.200.400', 'D23.529.942.200.400'], ['G07.345.155.500', 'G07.345.500.325.377.625.050.500.175', 'G11.427.578.050.500.175'], ['G04.346'], ['D25.130.420', 'J01.637.05... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
PASK (proline-alanine-rich Ste20-related kinase) binds to tubulin and microtubules and is involved in microtubule stabilization. | Proline-alanine-rich Ste20-related kinase (PASK, also referred to as SPAK) has been linked to ion transport regulation. Here, we report two novel activities of PASK: binding to tubulin and microtubules and the promotion of microtubule assembly. Tubulin binding assay showed that full-length PASK and its kinase domain bo... | ['Animals', 'Binding Sites', 'COS Cells', 'Cells, Cultured', 'Chlorocebus aethiops', 'Microtubules', 'Protein Binding', 'Protein-Serine-Threonine Kinases', 'Swine', 'Tubulin'] | 18,675,246 | [['B01.050'], ['G02.111.570.120'], ['A11.251.210.172.500', 'A11.329.228.220'], ['A11.251'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['A11.284.430.214.190.750.602'], ['G02.111.679', 'G03.808'], ['D08.811.913.696.620.682.700'], ['B01.050.150.900.649.313.500.880'], ['D05.750.078.734.800', 'D12.776.220.600... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Postictal MR-changes. A rare and important differential diagnosis]. | BACKGROUND: Postictal MR findings are analyzed in the context of MR morphological differential diagnoses.PATIENTS AND METHODS: Postictal MRI was performed in 11 patients. The patterns of MR changes and their differential diagnoses were analyzed.RESULTS: Focal accentuation of signal increase in the cortex was found on T... | ['Adult', 'Aged', 'Brain', 'Brain Neoplasms', 'Child, Preschool', 'Diagnosis, Differential', 'Encephalitis', 'Female', 'Humans', 'Infant', 'Male', 'Middle Aged', 'Reproducibility of Results', 'Seizures', 'Sensitivity and Specificity'] | 18,210,060 | [['M01.060.116'], ['M01.060.116.100'], ['A08.186.211'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['M01.060.406.448'], ['E01.171'], ['C10.228.140.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.116.630'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', '... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Everolimus for Primary Intestinal Lymphangiectasia With Protein-Losing Enteropathy. | Primary intestinal lymphangiectasia (PIL), also known as Waldmann's disease, is an exudative enteropathy resulting from morphologic abnormalities in the intestinal lymphatics. In this article, we describe a 12-year-old boy with PIL that led to protein-losing enteropathy characterized by diarrhea, hypoalbuminemia associ... | ['Child', 'Diet, Fat-Restricted', 'Dose-Response Relationship, Drug', 'Everolimus', 'Follow-Up Studies', 'Humans', 'Immunosuppressive Agents', 'Lymphangiectasis, Intestinal', 'Lymphedema', 'Male', 'Protein-Losing Enteropathies'] | 26,908,672 | [['M01.060.406'], ['E02.642.249.260', 'G07.203.650.240.260'], ['G07.690.773.875', 'G07.690.936.500'], ['D02.540.505.760.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['C15.604.360.500', 'C15.604... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Socioeconomic Predictors of Incident Depression in Systemic Lupus Erythematosus. | OBJECTIVE: To assess different measures of socioeconomic status (SES) as predictors of incident depression among women with systemic lupus erythematosus (SLE).METHODS: Data were derived from the 2010-2015 waves of the Lupus Outcomes Study, where individuals with confirmed SLE were interviewed annually by telephone. Dep... | ['Adult', 'Aged', 'Depression', 'Educational Status', 'Female', 'Humans', 'Incidence', 'Income', 'Lupus Erythematosus, Systemic', 'Mental Health', 'Middle Aged', 'Poverty', 'Risk Factors', 'San Francisco', 'Social Determinants of Health', 'Socioeconomic Factors', 'Stress, Psychological'] | 28,371,529 | [['M01.060.116'], ['M01.060.116.100'], ['F01.145.126.350'], ['N01.824.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.308.985.525.375'], ['N01.824.417'], ['C17.300.480', 'C20.111.590'], ['F02.418', 'N01.400.500'], ['M... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Slow recrystallization of tripalmitoylglycerol from MCT oil observed by 2H NMR. | The crystallization and recrystallization of fats have a significant impact on the properties and quality of many food products. While crystallization has been the subject of a number of studies using pure triacylglycerols (TAG), recrystallization in similarly pure systems is rarely studied. In this work, perdeuterated... | ['Crystallization', 'Deuterium', 'Hot Temperature', 'Magnetic Resonance Spectroscopy', 'Oils', 'Solutions', 'Triglycerides'] | 17,880,150 | [['E05.196.300', 'G02.171'], ['D01.268.406.500', 'D01.362.340.500', 'D01.496.289'], ['G01.906.595.543', 'G16.500.275.063.725.710.380', 'G16.500.750.775.710.380', 'N06.230.300.100.725.232', 'N06.230.300.100.725.710.380'], ['E05.196.867.519'], ['D10.627'], ['D26.776'], ['D10.351.801']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Diagnosis of spontaneous bacterial peritonitis in cirrhotic patients in northeastern Brazil by use of rapid urine-screening test. | CONTEXT AND OBJECTIVE: Spontaneous bacterial peritonitis (SBP) is a frequent and severe complication of cirrhotic patients with ascites. It has been proposed that the reagent strip for leukocyte esterase designed for the testing of urine (Combur test UX) could be a useful tool for diagnosing SPB. The aim of this study ... | ['Ascites', 'Ascitic Fluid', 'Bacterial Infections', 'Bacteriological Techniques', 'Brazil', 'Carboxylic Ester Hydrolases', 'Female', 'Humans', 'Leukocyte Count', 'Liver Cirrhosis', 'Male', 'Middle Aged', 'Paracentesis', 'Peritonitis', 'Prospective Studies', 'Reagent Strips', 'Sensitivity and Specificity'] | 17,119,690 | [['C23.550.081'], ['A12.207.119'], ['C01.150.252'], ['E01.370.225.875.150', 'E05.200.875.150'], ['Z01.107.757.176'], ['D08.811.277.352.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.195.107.595', 'E01.370.225.625.107.595', 'E05.200.500.195.107.595', 'E05.200.625.107.595', 'E05.242.195.107.595... | ['Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Panax notoginseng saponins ameliorate impaired arterial vasodilation in SHRSP.Z-Lepr(fa) /lzmDmcr rats with metabolic syndrome. | Panax notoginseng saponins (PNS) are major components of Panax notoginseng, a herb with established clinical efficacy against vascular diseases. SHRSP.Z-Lepr(fa) /IzmDmcr (SHRSP.ZF) rats, a new animal model for metabolic syndrome, display an impaired vasorelaxation response in aortas and mesenteric arteries that is med... | ['Animals', 'Aorta', 'Biomarkers', 'Blood Pressure', 'Cyclic GMP', 'Disease Models, Animal', 'Male', 'Mesenteric Arteries', 'Metabolic Syndrome', 'Nitric Oxide', 'Oxidative Stress', 'Panax notoginseng', 'Rats', 'Saponins', 'Signal Transduction', 'Vasodilation'] | 26,784,885 | [['B01.050'], ['A07.015.114.056'], ['D23.101'], ['E01.370.600.875.249', 'G09.330.380.076'], ['D03.633.100.759.646.454.160', 'D13.695.462.275', 'D13.695.667.454.160', 'D13.695.827.426.160'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A07.015.114.565'], ['C18.452.394.968.500.570', 'C18.452.625'], ['D01.339.387', 'D... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effects of modeled microgravity on growth kinetics, antibiotic susceptibility, cold growth, and the virulence potential of a Yersinia pestis ymoA-deficient mutant and its isogenic parental strain. | Previously, we reported that there was no enhancement in the virulence potential (as measured by cell culture infections) of the bacterial pathogen Yersinia pestis (YP) following modeled microgravity/clinorotation growth. We have now further characterized the effects of clinorotation (CR) on YP growth kinetics, antibio... | ['Animals', 'Anti-Bacterial Agents', 'Antigens, Bacterial', 'Bacterial Proteins', 'Cold Temperature', 'Drug Resistance, Microbial', 'Female', 'HeLa Cells', 'Humans', 'Mice', 'Microbial Sensitivity Tests', 'Mutation', 'Phenotype', 'Plague', 'Pore Forming Cytotoxic Proteins', 'Rotation', 'Virulence', 'Weightlessness', 'Y... | 23,988,036 | [['B01.050'], ['D27.505.954.122.085'], ['D23.050.161'], ['D12.776.097'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['G06.225', 'G07.690.773.984.269'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Ayahuasca and the process of regulation in Brazil and internationally: implications and challenges. | BACKGROUND: This paper provides a summary and analysis of the regulation of ayahuasca in Brazil, from its prohibition in the mid-eighties to the recent adoption of CONAD's (Conselho Nacional de Pol?ticas sobre Drogas) 2010 Resolution, which established a set of rules, norms and ethical principles to be applied to relig... | ['Banisteriopsis', 'Brazil', 'Drug and Narcotic Control', 'Humans', 'International Cooperation', 'Plant Extracts', 'Psychotropic Drugs', 'Religion'] | 21,856,141 | [['B01.650.940.800.575.912.250.859.797.690.099'], ['Z01.107.757.176'], ['I01.880.604.605.250', 'N03.706.615.402.250', 'N04.452.706.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.615.500'], ['D20.215.784.500', 'D26.667'], ['D27.505.954.427.700'], ['K01.844']] | ['Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Humanities [K]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Characterization of Non-Infectious Virus-Like Particle Surrogates for Viral Clearance Applications. | Viral clearance is a critical aspect of biopharmaceutical manufacturing process validation. To determine the viral clearance efficacy of downstream chromatography and filtration steps, live viral "spiking" studies are conducted with model mammalian viruses such as minute virus of mice (MVM). However, due to biosafety c... | ['Animals', 'Mice', 'Minute Virus of Mice'] | 28,281,181 | [['B01.050'], ['B01.050.150.900.649.313.992.635.505.500'], ['B04.280.580.650.600.550']] | ['Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The delineation of the fourth walking leg segment is temporally linked to posterior segmentation in the mite Archegozetes longisetosus (Acari: Oribatida, Trhypochthoniidae). | Acari (mites and ticks) lack external segmentation, with the only indication of segmentation being the appendages of the prosoma (chelicerae, pedipalps, and four pairs of walking legs). Acari also have a mode of development in which the formation of the fourth walking leg is suppressed until the nymphal stages, followi... | ['Acari', 'Animals', 'Arthropod Proteins', 'Body Patterning', 'Extremities', 'Hedgehog Proteins', 'Homeodomain Proteins', 'Nymph', 'Transcription Factors'] | 22,765,209 | [['B01.050.500.131.166.132'], ['B01.050'], ['D12.776.093'], ['G07.345.500.100'], ['A01.378'], ['D12.644.276.671', 'D12.776.467.671', 'D23.529.671'], ['D12.776.260.400'], ['B05.500.650', 'G07.345.500.550.500.650'], ['D12.776.930']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differential regulation of Fas-mediated apoptosis in both thyrocyte and lymphocyte cellular compartments correlates with opposite phenotypic manifestations of autoimmune thyroid disease. | Several mechanisms are probably involved in determining the evolution of autoimmune thyroid disease (AITD) towards either hypothyroidism and the clinical syndrome known as Hashimoto's thyroiditis (HT) or toward hyperthyroidism and the symptoms of Graves' disease (GD). To gain further insight into such mechanisms we per... | ['Adult', 'Aged', 'Apoptosis', 'Autoimmune Diseases', 'Fas Ligand Protein', 'Female', 'Gene Expression Regulation', 'Graves Disease', 'Humans', 'Lymphocytes', 'Male', 'Membrane Glycoproteins', 'Middle Aged', 'Phenotype', 'Proto-Oncogene Proteins c-bcl-2', 'RNA, Messenger', 'Reverse Transcriptase Polymerase Chain Reacti... | 11,327,614 | [['M01.060.116'], ['M01.060.116.100'], ['G04.146.954.035'], ['C20.111'], ['D12.644.276.374.750.249', 'D12.776.395.550.312', 'D12.776.467.374.750.249', 'D12.776.543.550.312', 'D23.529.374.750.249'], ['G05.308'], ['C11.675.349.500', 'C19.874.283.605', 'C19.874.397.370', 'C20.111.555'], ['B01.050.150.900.649.313.988.400.1... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Serum sphinganine and the sphinganine to sphingosine ratio as a biomarker of dietary fumonisins during chronic exposure in ducks. | Sphinganine concentration (Sa) and sphinganine to sphingosine ratio (Sa/So) are sensitive biomarkers of fumonisin B1 (FB1) exposure in animals and have been proposed to reveal FB1 exposure in humans. They correlate with liver and kidney toxicity and often precede signs of toxicity. However, the use of Sa and Sa/So is c... | ['Animals', 'Biomarkers', 'Carcinogens, Environmental', 'Clinical Chemistry Tests', 'Diet', 'Dose-Response Relationship, Drug', 'Ducks', 'Fumonisins', 'Liver', 'Liver Function Tests', 'Mycotoxins', 'Organ Size', 'Sphingosine', 'Toxicity Tests'] | 16,413,517 | [['B01.050'], ['D23.101'], ['D27.888.569.100.125'], ['E01.370.225.124', 'E05.200.124'], ['G07.203.650.240'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.150.900.248.050.200', 'B01.050.150.900.248.690.345'], ['D02.455.326.146.432', 'D23.946.587.385'], ['A03.620'], ['E01.370.372.460'], ['D23.946.587'], ['E01.370.60... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impaired conflict monitoring in Parkinson's disease patients during an oculomotor redirect task. | Fallibility is inherent in human cognition and so a system that will monitor performance is indispensable. While behavioral evidence for such a system derives from the finding that subjects slow down after trials that are likely to produce errors, the neural and behavioral characterization that enables such control is ... | ['Adult', 'Aged', 'Analysis of Variance', 'Attention Deficit Disorder with Hyperactivity', 'Case-Control Studies', 'Eye Movements', 'Humans', 'Memory Disorders', 'Middle Aged', 'Neuropsychological Tests', 'Parkinson Disease', 'Photic Stimulation', 'Reaction Time', 'Signal Detection, Psychological', 'Time Factors'] | 21,082,315 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['F03.625.094.150'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['G11.427.410.140', 'G14.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.525', 'C23.888.592.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Long-term prevalence of post-traumatic stress disorder symptoms in patients after secondary peritonitis. | INTRODUCTION: The aim of this study was to determine the long-term prevalence of post-traumatic stress disorder (PTSD) symptomology in patients following secondary peritonitis and to determine whether the prevalence of PTSD-related symptoms differed between patients admitted to the intensive care unit (ICU) and patient... | ['Acute Disease', 'Adult', 'Aged', 'Cohort Studies', 'Critical Care', 'Female', 'Humans', 'Intensive Care Units', 'Logistic Models', 'Male', 'Memory', 'Middle Aged', 'Peritonitis', 'Prevalence', 'Retrospective Studies', 'Risk Factors', 'Stress Disorders, Post-Traumatic', 'Surveys and Questionnaires', 'Survivors'] | 17,319,937 | [['C23.550.291.125'], ['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E02.760.190', 'N02.421.585.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.388.493'], ['E05.318.740.500.525', 'E05.318.740.600.800.450', 'E05.318.740.750.450', '... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Activation-dependent alpha5beta1 integrin-mediated adhesion to fibronectin decreases proliferation of chronic myelogenous leukemia progenitors and K562 cells. | Chronic myelogenous leukemia (CML) is a malignant disease of the hematopoietic stem cell characterized by abnormal circulation and proliferation of malignant progenitors. In contrast to their normal counterparts, CML progenitors adhere poorly to bone marrow stroma or fibronectin (FN). Aside from anchoring progenitors i... | ['Antibodies, Monoclonal', 'Antigens, CD34', 'Antigens, Neoplasm', 'Blast Crisis', 'Cell Adhesion', 'Cell Death', 'Cell Differentiation', 'Cell Division', 'DNA Replication', 'DNA, Neoplasm', 'Fibronectins', 'HLA-DR Antigens', 'Humans', 'Leukemia, Myelogenous, Chronic, BCR-ABL Positive', 'Neoplasm Proteins', 'Neoplastic... | 8,630,410 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.301.264.035.134', 'D23.101.100.110.134'], ['D23.050.285'], ['C04.557.337.539.250.100', 'C04.697.098.500.110', 'C15.378.190.636.370.100', 'C23.550.727.098.500.110'], ['G04.022'], ['G04.146'], ['G04.152'], ['G04.144.... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Solid-phase synthesis of the alkenyldiarylmethane (ADAM) series of non-nucleoside HIV-1 reverse transcriptase inhibitors. | The Sonogashira and Stille cross-coupling reactions have been employed in the synthesis of several non-nucleoside reverse transcriptase inhibitors (NNRTIs) in the alkenyldiarylmethane (ADAM) series. The synthesis has been carried out both in solution and on a solid support. In contrast to previous syntheses of NNRTIs i... | ['Anti-HIV Agents', 'Caproates', 'Cell Line', 'HIV Reverse Transcriptase', 'HIV-1', 'Humans', 'Reverse Transcriptase Inhibitors', 'Stereoisomerism'] | 11,529,718 | [['D27.505.954.122.388.077.088'], ['D02.241.081.193', 'D10.251.400.326'], ['A11.251.210'], ['D08.811.913.696.445.308.300.750.187', 'D12.776.964.775.375.545.875', 'D12.776.964.775.375.750.187', 'D12.776.964.775.562.764.875', 'D12.776.964.900.750.500.545.875', 'D12.776.964.900.750.500.750.187', 'D12.776.964.970.600.850.3... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Brain chemistry and behaviour. | The functional organization of chemically transmitting synapses in the brain are described with special emphasis on recent studies demonstrating the localization of different transmitters to specific anatomical circuitries. The use of pharmacological tools for manipulating levels of chemical transmitters is referred to... | ['Animals', 'Behavior, Animal', 'Brain', 'Caudate Nucleus', 'Corpus Striatum', 'Dopamine', 'Humans', 'Norepinephrine', 'Nucleus Accumbens', 'Rats', 'Receptors, Dopamine', 'Schizophrenia', 'Substantia Nigra'] | 7,443,906 | [['B01.050'], ['F01.145.113'], ['A08.186.211'], ['A08.186.211.200.885.287.249.487.550.184'], ['A08.186.211.200.885.287.249.487'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559.389.657.166.175.342'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.033.100.291.502', 'D02.092.063.480', 'D02.092.211.21... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Protective immunization with a novel membrane protein of Plasmodium yoelii-infected erythrocytes. | Immunization with a particulate fraction of blood-stage antigens was shown previously to protect mice against Plasmodium yoelii malaria. To identify antigens inducing the protective response, sera from immunized mice were used to screen a P. yoelii cDNA expression library. Sequence analysis of one 2.6-kb cDNA clone ind... | ['Amino Acid Sequence', 'Animals', 'Antigens, Protozoan', 'Base Sequence', 'Cloning, Molecular', 'DNA, Protozoan', 'Disease Models, Animal', 'Erythrocytes', 'Gene Expression', 'Immunoblotting', 'Malaria', 'Malaria Vaccines', 'Membrane Proteins', 'Mice', 'Mice, Inbred BALB C', 'Mice, Inbred C57BL', 'Molecular Sequence D... | 9,916,076 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D23.050.293'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.393.220'], ['D13.444.308.442'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['G05.297'], ['E05.478.566.320', 'E05.601.470.320'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Tussive effect of capsaicin in patients with gastroesophageal reflux without cough. | The aim of this study was to clarify the influence of gastroesophageal reflux (GER) on cough threshold in patients with digestive symptoms but free from respiratory involvement. Of 57 consecutive subjects referred for 24-h esophageal pH monitoring because of digestive reflux symptoms, 29 patients free from respiratory ... | ['Capsaicin', 'Cough', 'Female', 'Gastroesophageal Reflux', 'Humans', 'Male', 'Middle Aged'] | 7,842,220 | [['D02.065.690.500', 'D02.455.326.271.690.222', 'D02.455.426.559.389.657.166.099', 'D03.132.760.200', 'D10.251.355.325.190'], ['C08.618.248', 'C23.888.852.293'], ['C06.405.117.119.500.484'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Notes about other epidemics in Colonial Chile]. | In chronicles or in the historiography of the Colony in Chile there are few references about epidemics different to smallpox; like typhus, typhoid fever, dysentery, etc. Almost all, fast spreading in the country and some with high lethality, which led to overflowing the capacity of hospitals in the Chilean colonial per... | ['Chile', 'Communicable Diseases', 'Epidemics', 'Female', 'History, 18th Century', 'Humans', 'Male'] | 26,633,117 | [['Z01.107.757.235'], ['C01.221', 'C23.550.291.531'], ['N06.850.290.200'], ['K01.400.504.875'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Geographicals [Z]', 'Diseases [C]', 'Health Care [N]', 'Humanities [K]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
[Pediatric head injuries. Observations in pediatric surgery. 1,019 cases (author's transl)]. | For 5 years, 1,019 children with head injury have been admitted in pediatric surgery. More often the patient is a boy one to five years old. 8.9 p. cent of the children had one or more other body injury. A skull fracture was found in 23 p. cent of the cases without influence on the evolutivity but a repeated clinical e... | ['Adolescent', 'Age Factors', 'Brain Injuries', 'Child', 'Child, Preschool', 'Electroencephalography', 'Female', 'France', 'Humans', 'Infant', 'Male', 'Pediatrics', 'Prognosis', 'Sex Factors', 'Skull Fractures', 'Surgery Department, Hospital'] | 7,377,566 | [['M01.060.057'], ['N05.715.350.075', 'N06.850.490.250'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.376.300', 'E01.370.405.245'], ['Z01.542.286'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['H02.403.670'], ['E01.789'], ['N05.715.35... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Cyclic AMP activates p38 mitogen-activated protein kinase in Th2 cells: phosphorylation of GATA-3 and stimulation of Th2 cytokine gene expression. | cAMP is an important second messenger with immunomodulatory properties. Elevation of intracellular cAMP in T cells, induced by agents such as IL-1alpha or PGs, inhibits T cell activation. In effector T cells, an increase in the level of intracellular cAMP inhibits cytokine production in Th1 cells but stimulates cytokin... | ['Adjuvants, Immunologic', 'Animals', 'Cell Line', 'Cyclic AMP', 'Cyclic AMP-Dependent Protein Kinases', 'Cytokines', 'DNA-Binding Proteins', 'Enzyme Activation', 'Enzyme Inhibitors', 'GATA3 Transcription Factor', 'Gene Expression Regulation', 'Imidazoles', 'Interleukin-13', 'Interleukin-5', 'Mice', 'Mitogen-Activated ... | 11,067,915 | [['D27.505.696.477.067'], ['B01.050'], ['A11.251.210'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D08.811.913.696.620.682.700.150.125', 'D12.644.360.200.125', 'D12.776.476.200.125'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['D12.776.260'], ['G02.1... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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