Title stringlengths 1 395 ⌀ | abstractText stringlengths 57 5.98k | meshMajor stringlengths 14 1.03k | pmid int64 22 33.2M | meshid stringlengths 2 3.14k | meshroot stringlengths 2 421 | A int64 0 1 | B int64 0 1 | C int64 0 1 | D int64 0 1 | E int64 0 1 | F int64 0 1 | G int64 0 1 | H int64 0 1 | I int64 0 1 | J int64 0 1 | L int64 0 1 | M int64 0 1 | N int64 0 1 | Z int64 0 1 |
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Contact hypersensitivity to stainless steel cages (chromium metal) in hairless descendants of mexican hairless dogs. | Canine allergic contact hypersensitivity is an uncommon skin disease as compared with human beings because hair coat is a good natural barrier to environmental contactants. In our colony of hairless dogs housed in stainless steel cages, we have encountered spontaneously occurring contact hypersensitivity. The author ha... | ['Animals', 'Chromium', 'Dermatitis, Contact', 'Dog Diseases', 'Dogs', 'Langerhans Cells', 'Male', 'Mast Cells', 'Skin', 'Skin Tests', 'Stainless Steel'] | 17,366,565 | [['B01.050'], ['D01.268.556.175', 'D01.268.956.124', 'D01.552.544.175'], ['C17.800.174.255', 'C17.800.815.255'], ['C22.268'], ['B01.050.150.900.649.313.750.250.216.200'], ['A11.066.270.500', 'A11.436.270.545', 'A15.382.066.270.500', 'A15.382.670.260.500'], ['A11.329.427', 'A15.382.652'], ['A17.815'], ['E01.370.225.812.... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Residues flanking the COOH-terminal C-region of a model eukaryotic signal peptide influence the site of its cleavage by signal peptidase and the extent of coupling of its co-translational translocation and proteolytic processing in vitro. | The polar, COOH-terminal c-region of signal peptides has been considered to be most important for influencing the efficiency and fidelity of signal peptidase cleavage while the hydrophobic core or h-region appears indispensable for initiating translocation. To identify structural features of residues flanking the c-reg... | ['Amino Acid Sequence', 'Apolipoprotein A-II', 'Apolipoproteins A', 'Base Sequence', 'Biological Transport', 'Cell Compartmentation', 'Cloning, Molecular', 'DNA Mutational Analysis', 'Endopeptidases', 'In Vitro Techniques', 'Membrane Proteins', 'Microsomes', 'Molecular Sequence Data', 'Oligonucleotides', 'Protein Biosy... | 2,123,875 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D10.532.091.200.150', 'D12.776.070.400.200.150', 'D12.776.521.120.200.150'], ['D10.532.091.200', 'D12.776.070.400.200', 'D12.776.521.120.200'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G03.143'], ['G04.128'], ['E05.393.220'], ['E05.393.760.700.300'], ['... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Structure-activity relationship of a u-type antimicrobial microemulsion system. | The structure-activity relationship of a U-type antimicrobial microemulsion system containing glycerol monolaurate and ethanol at a 1?1 mass ratio as oil phase and Tween 20 as surfactant were investigated along a water dilution line at a ratio of 80?20 mass% surfactant/oil phase, based on a pseudo-ternary phase diagram... | ['Anti-Infective Agents', 'Calorimetry, Differential Scanning', 'Emulsions', 'Escherichia coli', 'Ethanol', 'Hydrophobic and Hydrophilic Interactions', 'Laurates', 'Micelles', 'Monoglycerides', 'Particle Size', 'Polysorbates', 'Staphylococcus aureus', 'Structure-Activity Relationship', 'Temperature', 'Thermodynamics'] | 24,204,605 | [['D27.505.954.122'], ['E05.196.131.310', 'E05.196.370.310'], ['D20.280.260', 'D26.255.165.260'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D02.033.375'], ['G02.409'], ['D10.251.500.410'], ['D05.374', 'D26.255.560'], ['D10.351.676'], ['G02.712'], ['D02.033.455.250.700.690', 'D05.750.741.700', 'D25.720.7... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
[Lung cancer with elevated amylase activity. One observation with study of amylase's isoenzymes (author's transl)]. | Amylase is composed by two isoenzymes groups: pancreatic or salivary type. This last part can be increased in many diseases. A case of lung cancer with elevated amylase activity in blood, urine and pleural fluid is reported in a 74-year-old man. This increase was due to salivary type isoamylases with an unusual compone... | ['Adenocarcinoma', 'Aged', 'Amylases', 'Humans', 'Isoenzymes', 'Lung Neoplasms', 'Male', 'Neuraminidase', 'Pleural Effusion', 'Saliva'] | 493,026 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Glutamine-enriched total parenteral nutrition preserves respiratory immunity and improves survival to a Pseudomonas Pneumonia. | BACKGROUND: Addition of 2% glutamine (GLN), a specific lymphocyte fuel, prevents deleterious effects of TPN on gut-associated lymphoid tissue and IgA while preserving IgA-mediated upper respiratory immunity to influenza virus. We examined whether a 2% GLN-enhanced TPN solution preserves respiratory immunity to a lethal... | ['Animals', 'Glutamine', 'Immunity', 'Male', 'Mice', 'Mice, Inbred ICR', 'Parenteral Nutrition, Total', 'Pneumonia, Bacterial', 'Pseudomonas Infections', 'Respiratory System', 'Survival Analysis'] | 10,334,882 | [['B01.050'], ['D12.125.068.330', 'D12.125.095.461', 'D12.125.154.424'], ['G12.450'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.510', 'B01.050.150.900.649.313.992.635.505.500.400.510'], ['E02.421.505.575', 'E02.642.500.505.750'], ['C01.150.252.620', 'C01.748.610.540', 'C08.381.677.540', 'C0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Success, failure, and spreading speeds for invasions on spatial gradients. | We study a model that describes the spatial spread of a species along a habitat gradient on which the species' growth increases. Mathematical analysis is provided to determine the spreading dynamics of the model. We demonstrate that the species may succeed or fail in local invasion depending on the species' growth func... | ['Animals', 'Ecosystem', 'Introduced Species', 'Mathematical Concepts', 'Models, Biological', 'Population Dynamics'] | 24,562,814 | [['B01.050'], ['G16.500.275.157', 'N06.230.124'], ['B01.050.050.580', 'G16.500.275.157.049.400', 'N06.230.124.049.400'], ['G17'], ['E05.599.395'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Increase in gamma-glutamylcysteine synthetase activity as a mechanism for butylated hydroxyanisole-mediated elevation of hepatic glutathione. | Previous studies have demonstrated that dietary administration of butylated hydroxyanisole (BHA) and other phenolic antioxidants increases hepatic glutathione (GSH). The purpose of this study was to examine whether BHA increases GSH by increasing the activity of gamma-glutamylcysteine synthetase (GCS), the rate-limitin... | ['Animals', 'Butylated Hydroxyanisole', 'Diet', 'Glutamate-Cysteine Ligase', 'Glutathione', 'In Vitro Techniques', 'Liver', 'Male', 'Mice', 'Mice, Inbred Strains'] | 7,910,419 | [['B01.050'], ['D02.355.601.200.324', 'D02.355.726.158.324', 'D02.455.426.559.389.657.654.158.324'], ['G07.203.650.240'], ['D08.811.464.259.850.400'], ['D12.644.456.448'], ['E05.481'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520', 'B01.050.150.900.649.313.992.635.505.500.400']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterizations of cholinesterases in golden apple snail (Pomacea canaliculata). | Cholinesterases (ChEs) have been identified in vertebrates and invertebrates. Inhibition of ChE activity in invertebrates, such as bivalve molluscs, has been used to evaluate the exposure of organophosphates, carbamate pesticides, and heavy metals in the marine system. The golden apple snail (Pomacea canaliculata) is c... | ['Acetylcholinesterase', 'Animals', 'Butyrylcholinesterase', 'Intestines', 'Organ Specificity', 'Snails'] | 24,217,797 | [['D08.811.277.352.100.170.176'], ['B01.050'], ['D08.811.277.352.100.170.250'], ['A03.556.124'], ['G07.650'], ['B01.050.500.644.400.750']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Potential and limitations of bovine-specific arrays for the analysis of mRNA levels in early development: preliminary analysis using a bovine embryonic array. | New insights into the early development of large mammals are becoming available through the measurement of differential mRNA levels in oocytes and preimplantation embryos. These advances in knowledge are rapidly picking up in pace, mainly owing to the advantages brought by new molecular biology approaches being develop... | ['Animals', 'Cattle', 'DNA, Complementary', 'Embryo Culture Techniques', 'Embryonic Development', 'Nucleic Acid Hybridization', 'Oligonucleotide Array Sequence Analysis', 'RNA, Messenger', 'Sequence Analysis, DNA'] | 15,745,631 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['E05.481.500.468'], ['G07.345.500.325.180', 'G08.686.784.170.104'], ['E05.393.661', 'G02.111.611'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05.601.640'], ['D13.444.7... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The influence of relationship dynamics on the psychosocial outcome of genetically related and unrelated living kidney donor-recipient pairs]. | OBJECTIVES: Renal diseases and their treatment can cause distress and psychosocial problems for both patients and relatives.METHODS: Relationship dynamics and parameters of quality of life were assessed in 10 genetically related (brothers) and 14 genetically unrelated donor-recipient pairs (spouses) involved in living ... | ['Adult', 'Altruism', 'Decision Making', 'Defense Mechanisms', 'Female', 'Follow-Up Studies', 'Humans', 'Interpersonal Relations', 'Kidney Transplantation', 'Living Donors', 'Male', 'Middle Aged', 'Motivation', 'Quality of Life', 'Retrospective Studies', 'Surveys and Questionnaires', 'Transplantation, Homologous', 'Tra... | 22,427,127 | [['M01.060.116'], ['F01.145.813.090'], ['F02.463.785.373'], ['F01.393'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401'], ['E02.870.500', 'E04.936.450.485', 'E04.950.774.400'], ['M01.898.656'], ['M01.060.116.630'... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
A phase I first-in-human trial of bardoxolone methyl in patients with advanced solid tumors and lymphomas. | PURPOSE: Bardoxolone methyl, a novel synthetic triterpenoid and antioxidant inflammation modulator, potently induces Nrf2 and inhibits NF-êB and Janus-activated kinase/STAT signaling. This first-in-human phase I clinical trial aimed to determine the dose-limiting toxicities (DLT), maximum tolerated dose (MTD), and appr... | ['Adult', 'Aged', 'Aged, 80 and over', 'Antineoplastic Agents', 'Carcinoma, Renal Cell', 'Colorectal Neoplasms', 'Cyclin D1', 'Dose-Response Relationship, Drug', 'Drug Administration Schedule', 'Female', 'Humans', 'Janus Kinases', 'Kidney Neoplasms', 'Lymphoma', 'Male', 'Maximum Tolerated Dose', 'Melanoma', 'Middle Age... | 22,634,319 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.248'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Modeling event times with multiple outcomes using the Wiener process with drift. | Length of stay in hospital (LOS) is a widely used outcome measure in Health Services research, often acting as a surrogate for resource consumption or as a measure of efficiency. The distribution of LOS is typically highly skewed, with a few large observations. An interesting feature is the presence of multiple outcome... | ['Health Services Research', 'Hospital Mortality', 'Humans', 'Length of Stay', 'Likelihood Functions', 'Logistic Models', 'Outcome Assessment, Health Care', 'Patient Discharge', 'Patient Transfer', 'Proportional Hazards Models', 'Risk Assessment', 'Survival Analysis', 'Time', 'Treatment Failure'] | 15,130,049 | [['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['E05.318.308.985.550.400', 'N01.224.935.698.400', 'N06.850.505.400.975.550.400', 'N06.850.520.308.985.550.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.400.480', 'N02.421.585.400.480'], ['E05.318.740.500.475', 'E05.318.740.600.400', 'E05.599.835.5... | ['Disciplines and Occupations [H]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
[Treatment tactics of hemorroidal disease stage III-IV]. | The Miligan-Morgan's operation has long been considered to be the "golden standard" of hemorrhoids' stage I-III treatment. The invention of distal branches of the upper rectal artery' suture ligation with mucopexia and lifting of the anal canal mucosa discovered new possibilities for hemorrhoids surgery, though there a... | ['Adult', 'Aged', 'Aged, 80 and over', 'Angiography', 'Arteries', 'Comparative Effectiveness Research', 'Female', 'Hemorrhoidectomy', 'Hemorrhoids', 'Humans', 'Ligation', 'Male', 'Middle Aged', 'Preoperative Care', 'Rectum', 'Recurrence', 'Retrospective Studies', 'Severity of Illness Index', 'Tomography, X-Ray Computed... | 23,715,415 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.350.700.060', 'E01.370.370.050'], ['A07.015.114'], ['H01.770.644.145.360.500', 'N05.425.157'], ['E04.210.526'], ['C06.405.469.860.401', 'C14.907.449'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.426'], ['M01.060.116.630'], ['E02.760.7... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Unilateral anhidrosis: a rare presentation of atrial myxoma? | A 50-year-old Chinese woman, non-smoker, presented with a 6-month history of increased sweating on the right side of her face, exertional chest tightness and breathlessness. Although the patient presented with increased sweating on the right, further history and examination revealed unilateral, left-sided anhidrosis, l... | ['Female', 'Heart Neoplasms', 'Humans', 'Hypohidrosis', 'Middle Aged', 'Myxoma'] | 23,230,264 | [['C04.588.894.309', 'C14.280.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.800.946.370'], ['M01.060.116.630'], ['C04.557.450.565.550']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Platelet monoamine oxidase and plasma dopamine-beta-hydroxylase activities in non-abstinent chronic alcoholics. Relation to clinical parameters. | Platelet monoamine oxidase (MAO) and plasma dopamine-beta-hydroxylase (DBH) activities were determined in 27 male non-abstinent chronic alcoholics. Compared to 24 normals, no significant difference in both enzyme activities was found. Alcoholics with at least one alcoholic first degree relative had a trend toward lower... | ['Adult', 'Alcoholism', 'Blood Platelets', 'Dementia', 'Dopamine beta-Hydroxylase', 'Humans', 'Male', 'Middle Aged', 'Monoamine Oxidase', 'Regression Analysis'] | 3,608,795 | [['M01.060.116'], ['C25.775.100.250', 'F03.900.100.350'], ['A11.118.188', 'A15.145.229.188'], ['C10.228.140.380', 'F03.615.400'], ['D08.811.682.690.708.292'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D08.811.682.664.750'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750']] | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Atypical mycobacteria-induced cervical adenitis. Treatment by needle aspiration. | Atypical mycobacteria are among the most frequent causes of cervical adenitis. These unilateral nodes seldom present a treatment problem since surgical excision is curative. Occasionally, however, the affected cervical node lies adjacent to the facial nerve and/or its marginal mandibular branch. There can be a substant... | ['Adult', 'Antitubercular Agents', 'Child', 'Child, Preschool', 'Female', 'Humans', 'Infant', 'Lymphadenitis', 'Male', 'Mycobacterium Infections', 'Mycobacterium Infections, Nontuberculous', 'Neck', 'Nontuberculous Mycobacteria', 'Retrospective Studies', 'Suction', 'Time Factors'] | 3,365,339 | [['M01.060.116'], ['D27.505.954.122.085.255'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['C15.604.315'], ['C01.150.252.410.040.552'], ['C01.150.252.410.040.552.475'], ['A01.598'], ['B03.510.024.962.500.720', 'B03.510.460.400.410.552.552.720'], ['E05.318.372... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Evaluating the effect of reduced entrance surface dose on neonatal chest imaging using subjective image quality evaluation. | INTRODUCTION: As hospitalized neonates are radiosensitive and often require numerous X-rays, institutions should investigate the optimal beam parameter combinations to deliver diagnostically acceptable quality images at the lowest possible entrance surface dose (ESD). Using a subjective approach, this study evaluated t... | ['Animals', 'Biophysical Phenomena', 'Humans', 'Infant, Newborn', 'Models, Animal', 'Observer Variation', 'Rabbits', 'Radiation Dosage', 'Radiographic Image Interpretation, Computer-Assisted', 'Radiography, Thoracic'] | 27,542,577 | [['B01.050'], ['G01.154'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['E05.598'], ['E01.354.753', 'N02.421.450.600', 'N05.715.350.150.675', 'N06.850.490.500.250'], ['B01.050.150.900.649.313.968.700'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250'], ['E01.158.600.680', 'E01.370.350.350.700... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Age affects outcomes in chronic kidney disease. | Chronic kidney disease (CKD) is common among the elderly. However, little is known about how the clinical implications of CKD vary with age. We examined the age-specific incidence of death, treated end-stage renal disease (ESRD), and change in estimated glomerular filtration rate (eGFR) among 209,622 US veterans with C... | ['Adolescent', 'Adult', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Female', 'Glomerular Filtration Rate', 'Humans', 'Kidney Failure, Chronic', 'Male', 'Middle Aged', 'United States'] | 17,855,638 | [['M01.060.057'], ['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E01.370.390.400.300', 'G08.852.357'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.780.750.500', 'C13.351.968.419.780.750.500'], ['M01.060.116.630'], ['Z01.107.567.875']] | ['Named Groups [M]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Hospital-based Emergency Department Visits with Periapical Abscess: Updated Estimates from 7 Years. | INTRODUCTION: The impact of the Affordable Care Act (ACA) on the utilization of the emergency department (ED) for periapical abscess (PA) is unknown. The objectives of this study were to provide nationwide estimates of hospital-based ED visits with PA and to examine the effect of the ACA on the use of EDs for PAs.METHO... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Ambulatory Care', 'Dental Care', 'Emergency Medical Services', 'Emergency Service, Hospital', 'Female', 'Humans', 'Male', 'Middle Aged', 'Patient Acceptance of Health Care', 'Periapical Abscess', 'Retrospective Studies', 'Time Factors', 'Young Adult'] | 30,803,531 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.760.106', 'N02.421.585.106'], ['E06.170', 'N02.421.240.190'], ['N02.421.297'], ['N02.278.216.500.968.336', 'N02.421.297.195', 'N04.452.442.452.422.336'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.100... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Increased susceptibility to liver damage from pneumoperitoneum in a murine model of biliary atresia. | HYPOTHESIS: We hypothesized that livers with biliary atresia (BA) are more susceptible to the harmful effects of a high-pressure CO(2) pneumoperitoneum (PP) than healthy livers.METHODS: A murine model of BA was used in this experiment. Mice were divided into 6 groups: (1) control Balb/c; (2) control Balb/c, CO(2)-PP; (... | ['Animals', 'Biliary Atresia', 'Disease Models, Animal', 'Disease Susceptibility', 'Liver Failure', 'Mice', 'Mice, Inbred BALB C', 'Pneumoperitoneum, Artificial'] | 20,850,622 | [['B01.050'], ['C06.130.120.123', 'C06.198.125', 'C16.131.314.125'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.291.687', 'G07.100.250'], ['C06.552.308.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['E01.370.388.605'... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Treatment of tibial avulsion fracture at the insertion of the posterior cruciate ligament through a minimally posteromedial transverse incision in the hip knee flexion]. | OBJECTIVE: To explore the methods and outcomes of a minimally posteromedial transverse incision in the hip knee flexion for the treatment of tibial avulsion fracture at the insertion of posterior cruciate ligament (PCL).METHODS: Twenty-one patients with tibial avulsion fracture at the insertion of PCL treated with a mi... | ['Adult', 'Bone Screws', 'Female', 'Fracture Fixation, Internal', 'Hip Joint', 'Humans', 'Knee Joint', 'Male', 'Middle Aged', 'Minimally Invasive Surgical Procedures', 'Posterior Cruciate Ligament', 'Tibial Fractures'] | 25,823,132 | [['M01.060.116'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['E04.555.300.300'], ['A02.835.583.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['M01.060.116.630'], ['E04.502'], ['A02.513.514.600', 'A02.835.583.512.600', 'A10.165.669.514.600'], ['C26.404.875'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Saccade abnormalities in autopsy-confirmed frontotemporal lobar degeneration and Alzheimer disease. | BACKGROUND: Deficits in the generation and control of saccades have been described in clinically defined frontotemporal dementia (FTD) and Alzheimer disease (AD).OBJECTIVE: To determine the saccade abnormalities associated with autopsy-defined cases of frontotemporal lobar degeneration (FTLD) and of AD, because clinica... | ['Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Autopsy', 'Case-Control Studies', 'Chi-Square Distribution', 'Female', 'Frontotemporal Lobar Degeneration', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Middle Aged', 'Neuropsychological Tests', 'Ocular Motility Disorders', 'Psychiatric Status Rating Scales', 'ROC... | 22,491,196 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['E01.370.060', 'E05.070', 'I01.198.780.937.120'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.8... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Characterization of the pattern of inflammatory cell influx in chicks following the intraperitoneal administration of live Salmonella enteritidis and Salmonella enteritidis-immune lymphokines. | We characterized the inflammatory cell influx in day-old chicks induced by the i.p. administration of live Salmonella enteritidis (SE) and lymphokines from concanavalin A-stimulated SE-immune T lymphocytes (ILK). An i.p. injection of ILK along with 5 x 10(3) cfu SE increased the survival rate of chicks 48 h later from ... | ['Animals', 'Arachidonic Acid', 'Cell Movement', 'Chickens', 'Female', 'Inflammation', 'Lipopolysaccharides', 'Lymphokines', 'Peritoneal Cavity', 'Phagocytes', 'Poultry Diseases', 'Salmonella Infections, Animal', 'Salmonella enteritidis'] | 7,899,216 | [['B01.050'], ['D10.251.355.255.100.100', 'D10.251.355.310.166.100'], ['G04.198', 'G07.568.500.180'], ['B01.050.150.900.248.350.150', 'B01.050.150.900.248.690.192'], ['C23.550.470'], ['D09.400.500', 'D09.698.718.450', 'D10.494', 'D23.050.161.616.525', 'D23.946.123.329.500'], ['D12.644.276.374.480', 'D12.776.467.374.480... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Renin gene rs1464816 polymorphism contributes to chronic kidney disease progression in ADPKD. | BACKGROUND: Autosomal dominant polycystic kidney disease (ADPKD) is a monogenic disorder and is a common genetic cause of chronic renal failure in children and adults. The enzyme renin plays a key role in the RAAS cascade and an important role in the development of hypertension and progression of renal disease in ADPKD... | ['Adult', 'Aged', 'Chronic Disease', 'Female', 'Genotype', 'Humans', 'Male', 'Middle Aged', 'Polycystic Kidney, Autosomal Dominant', 'Polymorphism, Single Nucleotide', 'Renin'] | 26,753,721 | [['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.500'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C12.777.419.403.875.500', 'C13.351.968.419.403.875.500', 'C16.131.077.717.500', 'C16.320.184.625.500'], ['G05.365.795.598'], ['D08.811.277.656.074.500.780', 'D08.811.277.656.3... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Alcohol-discrimination in gerbils: interactions with bemegride, DH-524, Amphetamine, and delta9-THC. | Male gerbils were trained to discriminate the effects of an injection of alcohol (1.0, 1.5, and 2.0 g/kg) from the nondrug condition in a T-shaped maze. The formation of the discrimination was related to the training dose used, the high dose (2 g/kg) being the most rapidly discriminable condition. After having reached ... | ['Animals', 'Bemegride', 'Dextroamphetamine', 'Discrimination, Psychological', 'Dronabinol', 'Drug Interactions', 'Ethanol', 'Gerbillinae', 'Imidazoles', 'Male', 'Phenobarbital', 'Time Factors'] | 901,060 | [['B01.050'], ['D03.383.725.791.100'], ['D02.092.471.683.152.110.200'], ['F02.463.593.257'], ['D02.455.849.090.810'], ['G07.690.773.968'], ['D02.033.375'], ['B01.050.150.900.649.313.992.635.300'], ['D03.383.129.308'], ['D03.383.742.698.253.650'], ['G01.910.857']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Neonatal renovascular hypertension due to prenatal traumatic retroperitoneal hematoma. | This report describes severe hypertension in a 7-week-old male infant found to have renovascular disease from an organized hematoma due to prenatal trauma. As such, this case illustrates a novel acquired, congenital mechanism of renovascular hypertension. The importance of considering prenatal as well as postnatal etio... | ['Female', 'Hematoma', 'Humans', 'Hypertension, Renal', 'Infant', 'Magnetic Resonance Imaging', 'Male', 'Pregnancy', 'Prenatal Injuries', 'Retroperitoneal Space', 'Wounds, Nonpenetrating'] | 15,711,950 | [['C23.550.414.838'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.777.419.331', 'C13.351.968.419.331', 'C14.907.489.631'], ['M01.060.703'], ['E01.370.350.825.500'], ['G08.686.784.769'], ['C13.703.824'], ['A01.923.047.025.750'], ['C26.974']] | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Long-term survivors of colorectal cancer with unresectable hepatic metastases. | Five patients with colorectal cancer and unresectable synchronous liver metastases have survived for over five years at this writing. Four of the five had multiple metastases over both lobes, as diagnosed preoperatively, and the other had multiple metastases in the right lobe not evident preoperatively. The primary foc... | ['Administration, Oral', 'Aged', 'Carcinoembryonic Antigen', 'Colonic Neoplasms', 'Female', 'Fluorouracil', 'Humans', 'Infusions, Intra-Arterial', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Mitomycin', 'Mitomycins', 'Rectal Neoplasms', 'Tegafur'] | 3,926,443 | [['E02.319.267.100'], ['M01.060.116.100'], ['D12.776.395.550.200.210', 'D12.776.543.550.200.210', 'D23.050.285.329', 'D23.050.301.350.210', 'D23.101.140.300'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['D03.383.742.698.8... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Usefulness of intraoperative insular electrocorticography in modified functional hemispherectomy. | BACKGROUND: The insular cortex is not routinely removed in modified functional hemispherectomy due to the risk of injury to the main arteries and to deep structures. Our study evaluates the safety and usefulness of applying intraoperative electrocorticography (ECoG) on the insular during the hemispherectomy.METHODS: We... | ['Cerebral Cortex', 'Child', 'Child, Preschool', 'Electrocorticography', 'Hemispherectomy', 'Humans', 'Infant', 'Intraoperative Neurophysiological Monitoring', 'Seizures'] | 28,841,860 | [['A08.186.211.200.885.287.500'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.376.300.294', 'E01.370.405.245.431'], ['E04.525.160.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E01.370.520.510.500', 'E01.370.520.596.500', 'E04.510.500'], ['C10.597.742', 'C23.888.592.742']] | ['Anatomy [A]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Influence of analyzed lubricant volumes on the amount and characteristics of generated wear particles from three different types of polyethylene liner materials. | The articulating components of artificial joints consist mainly of metals, ceramics, or polymers. Resulting abrasive wear particles can promote osteolysis and aseptic loosening of the endo-prosthetic implants. Ultra-high-molecular-weight-polyethylene is the material used most for bearing couples in total hip replacemen... | ['Algorithms', 'Cross-Linking Reagents', 'Hip Prosthesis', 'Humans', 'Lubricants', 'Particle Size', 'Particulate Matter', 'Polyethylenes', 'Prosthesis Failure', 'Ultrasonics'] | 28,636,252 | [['G17.035', 'L01.224.050'], ['D27.720.470.410.210'], ['E07.695.400.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.556'], ['G02.712'], ['D20.633'], ['D02.455.326.271.665.550', 'D05.750.716.507', 'D25.720.716.507', 'J01.637.051.720.716.507'], ['C23.550.767.865', 'E05.325.771'], ['H01.671.031.849']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 |
Low dose isotretinoin combined with tretinoin is effective to correct abnormalities of acne. | BACKGROUND: Isotretinoin is well known in the therapy of acne papulopustulosa and acne conglobata. No study has investigated the pathophysiological changes of the skin of acne patients, especially when low dose oral isotretinoin is given in combination with topical tretinoin.PATIENTS AND METHODS: 28 patients were treat... | ['Acne Vulgaris', 'Administration, Oral', 'Administration, Topical', 'Adolescent', 'Adult', 'Dermatologic Agents', 'Drug Administration Schedule', 'Drug Combinations', 'Female', 'Humans', 'Isotretinoin', 'Male', 'Severity of Illness Index', 'Skin', 'Treatment Outcome', 'Tretinoin'] | 16,281,880 | [['C17.800.030.150', 'C17.800.794.111'], ['E02.319.267.100'], ['E02.319.267.120'], ['M01.060.057'], ['M01.060.116'], ['D27.505.954.444'], ['E02.319.283'], ['D26.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.455.326.271.665.202.495.325', 'D02.455.426.392.368.367.379.249.700.325', 'D02.455.849.131.495.325... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Duodenal diverticula and choledocholithiasis in own material]. | The detectability of duodenal diverticula (DD), a common duodenal pathology, has been growing with the increasing availability of endoscopic examinations, and especially of endoscopic retrograde cholangio-pancreatography (ERCP). The study is a retrospective analysis of incidence rates of DD and accompanying diseases of... | ['Adult', 'Aged', 'Aged, 80 and over', 'Ampulla of Vater', 'Biliary Tract Neoplasms', 'Cholangiopancreatography, Endoscopic Retrograde', 'Choledocholithiasis', 'Constriction, Pathologic', 'Diagnosis, Differential', 'Diverticulum', 'Duodenal Diseases', 'Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Pancreatic ... | 16,786,758 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A03.159.183.079.300.950', 'A03.556.124.684.124.236', 'A03.556.875.249.160', 'A03.734.667.500'], ['C04.588.274.120', 'C06.130.320', 'C06.301.120'], ['E01.370.350.700.715.200.200', 'E01.370.372.200.200', 'E01.370.372.250.200', 'E01.370.388.250.250.160', 'E... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Expanded criteria donors, histological scoring, and prolonged cold ischemia: impact on renal graft survival. | The use of expanded donors or kidneys with preexistent chronic damage remains controversial, but they offer the opportunity to expand the donor pool. We investigated the impact of these conditions as predictors of graft survival among a cohort of recipients with prolonged cold ischemia times and a high incidence of del... | ['Adolescent', 'Adult', 'Aged', 'Biopsy', 'Child', 'Child, Preschool', 'Cohort Studies', 'Cold Ischemia', 'Graft Survival', 'Humans', 'Ischemia', 'Kidney Transplantation', 'Middle Aged', 'Multivariate Analysis', 'Renal Insufficiency', 'Reperfusion Injury', 'Retrospective Studies', 'Specimen Handling', 'Tissue Donors', ... | 22,099,786 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Determinants of functional tricuspid regurgitation in incomplete tricuspid valve closure: Doppler color flow study of 109 patients. | OBJECTIVES: The aim of this study was to investigate the association between the pattern of incomplete tricuspid valve closure and the presence of tricuspid regurgitation and to identify factors that determine the severity of regurgitation associated with this pattern.BACKGROUND: The incomplete tricuspid valve closure ... | ['Adult', 'Case-Control Studies', 'Echocardiography, Doppler', 'Female', 'Heart', 'Heart Diseases', 'Hemodynamics', 'Humans', 'Hypertension, Pulmonary', 'Male', 'Middle Aged', 'Severity of Illness Index', 'Tricuspid Valve', 'Tricuspid Valve Insufficiency'] | 8,034,882 | [['M01.060.116'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['A07.541'], ['C14.280'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C08.381.423', 'C14.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Use of leaves to inspect ectoparasites in wild chimpanzees: a third cultural variant? | We report 26 cases of using leaves as tools with which wild chimpanzees (Pan troglodytes schweinfurthii) in the Sonso community, Budongo Forest, Uganda, appeared to inspect objects removed during grooming. Careful removal of potential ectoparasites and delicate lip or manual placement on leaves followed by intense visu... | ['Animals', 'Animals, Wild', 'Ape Diseases', 'Behavior, Animal', 'Ectoparasitic Infestations', 'Eukaryota', 'Female', 'Grooming', 'Male', 'Pan troglodytes', 'Plant Leaves', 'Uganda'] | 15,179,558 | [['B01.050'], ['B01.050.050.300'], ['C22.735.050'], ['F01.145.113'], ['C01.610.858.211'], ['B01'], ['F01.145.113.111.453'], ['B01.050.150.900.649.313.988.400.112.400.620'], ['A18.024.812'], ['Z01.058.290.120.880']] | ['Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Exploring the differences between the three pyruvate kinase isozymes from Vibrio cholerae in a heterologous expression system. | OBJECTIVE: The genome of Vibrio cholerae has three paralog genes encoding for distinct pyruvate kinases. We were interested in elucidating whether they were expressed, and contributed to the pyruvate kinase activity of V. cholerae. VcIPK and VcIIPK were transformed and expressed in BL21-CodonPlus(DE3)-RIL strain, where... | ['Gene Expression', 'Genes, Bacterial', 'Isoenzymes', 'Pyruvate Kinase', 'Vibrio cholerae'] | 30,064,476 | [['G05.297'], ['G05.360.340.024.340.364.249', 'G05.360.340.358.024.249', 'G05.360.340.358.207.249'], ['D08.811.348', 'D12.776.800.300'], ['D08.811.913.696.620.695'], ['B03.440.450.900.859.225', 'B03.660.250.830.830.100']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Accuracy of ultrasonography and pregnancy-associated glycoprotein test for pregnancy diagnosis in buffaloes. | The aims of the present study were to evaluate and compare the accuracy of transrectal ultrasonography and pregnancy-associated glycoprotein radioimmunoassay (PAG-RIA) test for diagnosis of pregnancy in buffaloes. Two hundred and seventy-five buffalo cows and heifers were examined once for pregnancy diagnosis by transr... | ['Animals', 'Antibodies', 'Aspartic Acid Endopeptidases', 'Buffaloes', 'Female', 'Male', 'Predictive Value of Tests', 'Pregnancy', 'Pregnancy Proteins', 'Pregnancy Tests', 'Radioimmunoassay', 'Sensitivity and Specificity', 'Time Factors', 'Ultrasonography', 'Uterus'] | 17,884,156 | [['B01.050'], ['D12.776.124.486.485.114', 'D12.776.124.790.651.114', 'D12.776.377.715.548.114'], ['D08.811.277.656.074.500', 'D08.811.277.656.300.048'], ['B01.050.150.900.649.313.500.380.135'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['G08.686.784.769'], ['D12.776.780'], ['E01.370... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Social support and maladaptive coping as predictors of the change in physical health symptoms among persons living with HIV/AIDS. | This study examined social support and maladaptive coping as predictors of HIV-related health symptoms. Sixty-five men and women living with HIV/AIDS completed baseline measures assessing coping strategies, social support, and HIV-related health symptoms. The sample was primarily low-income and diverse with respect to ... | ['Adaptation, Psychological', 'Adult', 'Antiretroviral Therapy, Highly Active', 'Female', 'HIV Infections', 'Health Status', 'Humans', 'Male', 'Middle Aged', 'Patient Satisfaction', 'Psychotherapy, Group', 'Social Support', 'Surveys and Questionnaires'] | 16,164,385 | [['F01.058'], ['M01.060.116'], ['E02.319.310.075'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F01.100.150.750.6... | ['Psychiatry and Psychology [F]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Column centrifugation generates an intersubunit disulfide bridge in Escherichia coli F1-ATPase. | Passage of F1-ATPase through a centrifuge column [Penefsky, H. S. (1979) Methods Enzymol. 56, 527-530] caused formation of a product with a relative molecular mass of 72,000 as determined by sodium dodecyl sulfate/polyacrylamide gel electrophoresis. The product was identified as cross-linked alpha and delta subunits by... | ['Antibodies, Monoclonal', 'Bridged-Ring Compounds', 'Centrifugation', 'Disulfides', 'Electrophoresis, Polyacrylamide Gel', 'Escherichia coli', 'Proton-Translocating ATPases'] | 2,877,881 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D02.455.426.100', 'D04.075'], ['E05.181'], ['D01.248.497.158.874.390', 'D01.875.350.850.150', 'D02.886.520.150'], ['E05.196.401.402', 'E05.301.300.319'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['D08.811.27... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of HSPA8, an evolutionarily conserved oviductal protein, on boar and bull spermatozoa. | Previous studies have shown that a soluble protein fraction derived from preparations of apical plasma membrane (APM) of the oviductal epithelium enhances the in vitro survival of mammalian spermatozoa. Here, we show that the survival enhancing property of the soluble protein fraction seems to depend significantly upon... | ['Animals', 'Antibodies, Monoclonal', 'Blotting, Western', 'Cattle', 'Cell Membrane', 'Cell Survival', 'Cells, Cultured', 'Dose-Response Relationship, Drug', 'Epithelium', 'Fallopian Tubes', 'Female', 'Fertilization in Vitro', 'HSC70 Heat-Shock Proteins', 'Male', 'Microscopy, Fluorescence', 'Recombinant Proteins', 'Spe... | 18,996,976 | [['B01.050'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.649.313.500.380.271'], ['A11.284.149'], ['G04.346'], ['A11.251'], ['G07.690.773.875', 'G07.6... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Molecular mapping of the gene(s) conferring resistance to Soybean mosaic virus and Bean common mosaic virus in the soybean cultivar Raiden. | KEY MESSAGE: In the soybean cultivar Raiden, both a SMV-resistance gene and a BCMV-resistance gene were fine-mapped to a common region within the Rsv1 complex locus on chromosome 13, in which two CC-NBS-LRR resistance genes (Glyma.13g184800 and Glyma.13g184900) exhibited significant divergence between resistant and sus... | ['Chromosome Mapping', 'Disease Resistance', 'Genes, Dominant', 'Genes, Plant', 'Genetic Markers', 'Genotype', 'Microsatellite Repeats', 'Plant Diseases', 'Polymorphism, Single Nucleotide', 'Potyvirus', 'Selection, Genetic', 'Soybeans'] | 31,432,199 | [['E05.393.183'], ['C23.550.291.671', 'G12.450.564.250', 'G12.450.800.250', 'G15.630.250'], ['G05.360.340.024.340.240', 'G05.420.320'], ['G05.360.340.024.340.393', 'G05.360.340.365.500'], ['D23.101.387', 'G05.695.450'], ['G05.380'], ['G02.111.570.080.708.800.500', 'G05.360.080.708.800.500', 'G05.360.340.024.850.500'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The evolutionary origination of a novel expression pattern through an extreme heterochronic shift. | The evolutionary origins of morphological structures are thought to often depend upon the redeployment of old genes into new developmental settings. Although many examples of cis-regulatory divergence have shown how pre-existing patterns of gene expression have been altered, only a small number of case studies have tra... | ['Animals', 'Biological Evolution', 'Drosophilidae', 'Enhancer Elements, Genetic', 'Gene Expression Profiling', 'Mutation', 'Pupa', 'Thorax', 'Wings, Animal'] | 28,116,844 | [['B01.050'], ['G05.045', 'G16.075'], ['B01.050.500.131.617.720.500.500.750.310'], ['G02.111.570.080.689.330', 'G05.360.080.689.330', 'G05.360.340.024.340.137.750.249'], ['E05.393.332'], ['G05.365.590'], ['B05.500.700', 'G07.345.500.550.500.700'], ['A01.923.761'], ['A13.395.823']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The changing concentration of the older nonmetropolitan population, 1960-90. | Changes in the absolute and relative size of the elderly population since 1960 are decomposed into the underlying demographic components for metropolitan and nonmetropolitan areas and for subregions of the United States. Specifically, we examine the components of net migration and natural increase for those aged 0-64 a... | ['Aged', 'Humans', 'Population Dynamics', 'Rural Population', 'Suburban Population', 'United States'] | 8,228,002 | [['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['N01.600.725'], ['N01.600.775'], ['Z01.107.567.875']] | ['Named Groups [M]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Functional anatomy of occipital lobe seizures: an experimental study in rats. | Small amounts of penicillin were used to create a seizure focus in the primary visual cortex (area 17), extrastriate cortex (area 18 and 18a), and neighboring somatosensory and temporal areas in rats. Autoradiography with 14C-deoxyglucose was used to map the focus and the local cortical and long subcortical circuits. M... | ['Animals', 'Autoradiography', 'Brain Mapping', 'Cerebral Cortex', 'Dominance, Cerebral', 'Electroencephalography', 'Evoked Potentials', 'Female', 'Geniculate Bodies', 'Humans', 'Male', 'Neural Pathways', 'Occipital Lobe', 'Penicillin G', 'Rats', 'Seizures', 'Stereotyped Behavior', 'Visual Cortex'] | 571,569 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Erythropoietic bone marrow in the pigeon: development of its distribution and volume during growth and pneumatization of bones. | During postnatal development of the pigeon, a large portion of the skeleton becomes pneumatized, displacing the hemopoietic bone marrow. The consequences of pneumatization on distribution and quantity of bone marrow as well as the availability of other sites for hemopoiesis have been investigated. Hemopoietic marrow of... | ['Animals', 'Autoradiography', 'Bone Development', 'Bone Marrow', 'Bone Marrow Cells', 'Bone and Bones', 'Columbidae', 'Erythroid Precursor Cells', 'Hematopoiesis', 'Scintillation Counting'] | 2,304,081 | [['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['G07.345.500.325.377.625.050.500', 'G11.427.578.050.500'], ['A15.382.216'], ['A11.148', 'A15.378.316'], ['A02.835.232', 'A10.165.265'], ['B01.050.150.900.248.165.150'], ['A11.148.378.590.837.250', 'A11.443.240.497', 'A11.872.378.590.817.250', 'A1... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Correlated variation and population differentiation in satellite DNA abundance among lines of Drosophila melanogaster. | Tandemly repeating satellite DNA elements in heterochromatin occupy a substantial portion of many eukaryotic genomes. Although often characterized as genomic parasites deleterious to the host, they also can be crucial for essential processes such as chromosome segregation. Adding to their interest, satellite DNA elemen... | ['Animals', 'DNA, Satellite', 'Drosophila melanogaster', 'Evolution, Molecular', 'Genetic Variation', 'Genome, Insect', 'Sequence Analysis, DNA'] | 25,512,552 | [['B01.050'], ['D13.444.308.480', 'G02.111.570.080.708.800.150', 'G05.360.080.708.800.150', 'G05.360.340.024.220.150', 'G05.360.340.024.850.150'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['G05.045.250', 'G16.075.250'], ['G05.365'], ['G05.360.340.357'], ['E05.393.760.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The health status of mild to moderate intellectually handicapped adolescents. | To assist in the planning of school health services for the intellectually handicapped, a comprehensive evaluation of physical and emotional health, and social competence was completed on a group of students attending a school for educably retarded adolescents (IQ ranging form 60 to 85). This evaluation included a revi... | ['Adolescent', 'Child Behavior Disorders', 'Child Health Services', 'Dental Care', 'Female', 'Health', 'Health Status', 'Humans', 'Intellectual Disability', 'Male', 'Social Adjustment'] | 3,735,409 | [['M01.060.057'], ['F03.625.141'], ['N02.421.143.130'], ['E06.170', 'N02.421.240.190'], ['N01.400'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.597.606.360', 'C23.888.592.604.646', 'F01.700.687', 'F03.625.539'], ['F01.145.813.621']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Neurovascular coupling in the human somatosensory cortex: a single trial study. | Oscillations in the higher frequency range are closely related to regional brain hemodynamic changes. Here we investigated this neurovascular coupling in humans in response to electrical stimulation of the right median nerve. In a single-trial study, we simultaneously recorded hemodynamic fluctuations in the somatosens... | ['Adult', 'Beta Rhythm', 'Cerebrovascular Circulation', 'Data Interpretation, Statistical', 'Electric Stimulation', 'Electroencephalography', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetic Resonance Imaging', 'Magnetoencephalography', 'Male', 'Median Nerve', 'Neural Pathways', 'Oxyhemoglobins', 'S... | 21,475,088 | [['M01.060.116'], ['E01.370.376.300.150.750', 'E01.370.405.245.287.750', 'G07.265.087.750', 'G11.561.127.750'], ['G09.330.100.159'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['E05.723.402'], ['E01.370.376.300', 'E01.370.405.245'], ['B01.050.150.900.649... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Liver hepatocyte mitotic activity after a single injection of phenobarbital in immature male rats. | In contrast to multiple injections of phenobarbital, a single injection of 50 mg/kg body wt of phenobarbital into immature male rats results, after a transient increase in hepatocyte mitotic activity, in a marked decrease in hepatocyte mitotic activity to below control levels by day 3, followed by a return to control l... | ['Animals', 'Liver', 'Male', 'Mitosis', 'Phenobarbital', 'Rats'] | 970,661 | [['B01.050'], ['A03.620'], ['G04.144.220.220.781', 'G05.113.220.781'], ['D03.383.742.698.253.650'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Microglia in the giant cell encephalitis of acquired immune deficiency syndrome: proliferation, infection and fusion. | The autopsied brains of three homosexual men with acquired immune deficiency syndrome (AIDS), progressive encephalopathy and widespread multinucleated giant cell encephalitis were investigated by lectin and immunohistochemical methods to ascertain the cellular distribution of a human immunodeficiency virus (HIV) core p... | ['Acquired Immunodeficiency Syndrome', 'Adult', 'Aged', 'Encephalitis', 'HIV', 'HIV Antigens', 'Homosexuality', 'Humans', 'Male', 'Middle Aged', 'Neuroglia', 'Ricin', 'Viral Core Proteins'] | 3,176,903 | [['C01.221.250.875.040', 'C01.221.812.640.400.040', 'C01.778.640.400.040', 'C01.925.782.815.616.400.040', 'C01.925.813.400.040', 'C01.925.839.040', 'C20.673.480.040'], ['M01.060.116'], ['M01.060.116.100'], ['C10.228.140.430'], ['B04.820.650.589.650.350'], ['D23.050.327.520'], ['F01.145.802.975.500', 'G08.686.867.500'],... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Efficient splicing correction by PNA conjugation to an R6-Penetratin delivery peptide. | Sequence-specific interference with the nuclear pre-mRNA splicing machinery has received increased attention as an analytical tool and for development of therapeutics. It requires sequence-specific and high affinity binding of RNaseH-incompetent DNA mimics to pre-mRNA. Peptide nucleic acids (PNA) or phosphoramidate mor... | ['Active Transport, Cell Nucleus', 'Arginine', 'Carrier Proteins', 'Cell Nucleus', 'Chloroquine', 'Genes, Reporter', 'HeLa Cells', 'Humans', 'Peptide Nucleic Acids', 'RNA Splicing'] | 17,584,792 | [['G03.143.310.100', 'G03.143.700.100'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['D12.776.157'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['D03.633.100.810.050.180'], ['G05.360.340.024.340.435'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Improved Poly(3,4-Ethylenedioxythiophene) (PEDOT) for Neural Stimulation. | OBJECTIVE: This study compares the stability of three variations of the conductive polymer poly(3,4-ethylenedioxythiophene) or PEDOT for neural micro-stimulation under both in vitro and in vivo conditions. We examined PEDOT films deposited with counter-ions tetrafluoroborate (TFB) and poly(styrenesulfonate) (PSS), andP... | ['Animals', 'Borates', 'Boric Acids', 'Bridged Bicyclo Compounds, Heterocyclic', 'Drug Combinations', 'Electrodes, Implanted', 'Female', 'Nanotubes, Carbon', 'Neurons', 'Polymers', 'Polystyrenes', 'Rats', 'Rats, Long-Evans', 'Time Factors'] | 25,809,211 | [['B01.050'], ['D01.132.250.075', 'D01.248.497.158.076', 'D02.203.130.075'], ['D01.029.260.093', 'D01.132.250', 'D02.203.130'], ['D03.605.084'], ['D26.310'], ['E07.305.250.319', 'E07.695.202'], ['D01.268.150.250.500', 'J01.637.512.850.500'], ['A08.675', 'A11.671'], ['D05.750', 'D25.720', 'J01.637.051.720'], ['D02.455.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Procyanidin from peanut skin induces antiproliferative effect in human prostate carcinoma cells DU145. | In this study, the antiproliferative activity of peanut skin procyanidins (PSP) and six fractions (PSP-1?6) isolated from PSP by several chromatographic steps on the human prostate cancer DU145 cells were evaluated. The results showed that PSP and PSP-1?6 significantly inhibited the proliferation of DU145 cells. PSP-2 ... | ['Antineoplastic Agents', 'Apoptosis', 'Arachis', 'Biflavonoids', 'Caspase 3', 'Catechin', 'Cell Cycle Checkpoints', 'Cell Line, Tumor', 'Cell Proliferation', 'Chromatography, High Pressure Liquid', 'Humans', 'Male', 'Microscopy, Electron, Transmission', 'Proanthocyanidins', 'Prostatic Neoplasms', 'Proto-Oncogene Prote... | 29,654,773 | [['D27.505.954.248'], ['G04.146.954.035'], ['B01.650.940.800.575.912.250.401.077'], ['D03.383.663.283.266.450.190', 'D03.633.100.150.266.450.190'], ['D08.811.277.656.262.500.126.350.300', 'D08.811.277.656.300.200.126.350.300', 'D12.644.360.075.405.350.300', 'D12.776.476.075.405.350.300'], ['D03.383.663.283.240.190', 'D... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Delayed surgery for patients with femur and hip fractures-risk of deep venous thrombosis. | BACKGROUND: This prospective study explores the incidence of preoperative deep venous thrombosis (DVT) in a group of patients with hip and femur fracture who for various reasons experienced a delay of >24 hours from the time of injury until time of surgery. We also evaluated the results of preoperative treatment with i... | ['Adult', 'Aged', 'Aged, 80 and over', 'Anticoagulants', 'Female', 'Femoral Fractures', 'Hip Fractures', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Prospective Studies', 'Pulmonary Embolism', 'Regression Analysis', 'Risk Factors', 'Time Factors', 'Ultrasonography', 'Vena Cava Filters', 'Venous Thrombosis'] | 21,817,966 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.502.119'], ['C26.404.061', 'C26.558.276'], ['C26.404.061.425', 'C26.531.750', 'C26.558.276.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.975.525.375', 'N06.850.520.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Safe teleradiology: information assurance as project planning methodology. | The Georgetown University Medical Center Department of Radiology used a tailored version of OCTAVE, a self-directed information security risk assessment method, to design a teleradiology system that complied with the regulation implementing the security provisions of the Health Insurance Portability and Accountability ... | ['Academic Medical Centers', 'Computer Security', 'Confidentiality', 'District of Columbia', 'Health Insurance Portability and Accountability Act', 'Humans', 'Organizational Case Studies', 'Risk Assessment', 'Risk Management', 'Teleradiology', 'United States'] | 15,492,036 | [['N02.278.020'], ['L01.224.134', 'N04.452.910.200'], ['F04.096.544.335.240', 'I01.880.604.473.650.500', 'I01.880.604.583.080', 'N03.706.437.650.124', 'N03.706.535.230'], ['Z01.107.567.875.500.210', 'Z01.433.429'], ['N03.219.521.576.343.349', 'N03.706.615.273'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.34... | ['Health Care [N]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 |
[Effect of short-term antiorthostatic hypokinesia on the central and intracardiac hemodynamics and metabolism in a healthy human being]. | The right parts of the heart and the radial artery were catheterized in healthy male volunteers before and 5 days after strict bed rest in antiorthostatic position of the body (-4.5 degrees) After immobilization most values of central circulation showed no essential changes; the only exception were indices characterizi... | ['Acid-Base Equilibrium', 'Adult', 'Bed Rest', 'Blood Chemical Analysis', 'Cardiac Catheterization', 'Health', 'Heart', 'Hemodynamics', 'Humans', 'Male', 'Myocardial Contraction', 'Myocardium', 'Oxygen', 'Partial Pressure', 'Posture', 'Time Factors'] | 732,085 | [['G02.111.007', 'G02.300.176', 'G03.030', 'G07.410.110', 'G09.188.050'], ['M01.060.116'], ['E02.075'], ['E01.370.225.124.100', 'E05.200.124.100'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['N01.400'], ['A07.541'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.330.580', 'G11.427.... | ['Phenomena and Processes [G]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Age estimation from the permanent molar in northeast China by the method of average stage of attrition. | A new method of age estimation using permanent molars, the method of average stage of attrition (ASA), is described. A total of 633 molars, including the first molar (M1) and the second molar (M2) on both jaws, was collected from 57 cadavers and 54 modern dry skulls in northeast China. The attrition condition of the mo... | ['Adolescent', 'Adult', 'Age Determination by Teeth', 'Aged', 'Aging', 'China', 'Dentin', 'Female', 'Humans', 'Male', 'Middle Aged', 'Molar', 'Regression Analysis', 'Sensitivity and Specificity'] | 8,586,343 | [['M01.060.057'], ['M01.060.116'], ['E01.370.350.700.720.050', 'E01.370.600.024.650.500', 'E05.041.650.500', 'E06.342.764.142', 'E06.623.500'], ['M01.060.116.100'], ['G07.345.124'], ['Z01.252.474.164'], ['A14.549.167.900.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A14.549.167.860.525'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Antidiabetic therapy before and 1 year after discharge for patients manifesting in-hospital hyperglycemia. | BACKGROUND: While studies have evaluated the impact of hyperglycemia during hospitalization, little is known about its management before and after admission.METHODS: We sampled a managed care outpatient database (8547 patients) with linkage to inpatient data from June 1, 2003 to June 30, 2006, evaluating hyperglycemia ... | ['Blood Glucose', 'Diabetes Mellitus', 'Dose-Response Relationship, Drug', 'Female', 'Follow-Up Studies', 'Humans', 'Hyperglycemia', 'Hypoglycemic Agents', 'Incidence', 'Indiana', 'Inpatients', 'Insulin', 'Male', 'Middle Aged', 'Patient Discharge', 'Retrospective Studies', 'Time Factors', 'Treatment Outcome'] | 19,491,541 | [['D09.947.875.359.448.500'], ['C18.452.394.750', 'C19.246'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C18.452.394.952'], ['D27.505.696.422'], ['E05.318.308.985.525.375', 'N01.224... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Named Groups [M]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Meta-analysis on radiofrequency ablation in combination with transarterial chemoembolization for the treatment of hepatocellular carcinoma. | To evaluate the efficacy and safety of transcatheter arterial chemoembolization (TACE) combined with radiofrequency ablation (RFA) and TACE alone for hepatocellular carcinoma (HCC), Pubmed, Cochrane Library, Web of Science, China National Knowledge Infrastructure (CNKI) and Wanfang Datebases were searched for the rando... | ['Carcinoma, Hepatocellular', 'Catheter Ablation', 'Chemoembolization, Therapeutic', 'Combined Modality Therapy', 'Humans', 'Liver Neoplasms', 'Randomized Controlled Trials as Topic', 'Survival Analysis', 'Survival Rate', 'Treatment Outcome'] | 25,318,879 | [['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E02.808.750.500', 'E04.014.760.500'], ['E02.520.360.150', 'E02.926.500.150'], ['E02.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['E05.318.372.250.250.365.500', 'N05... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
MiRNA-directed regulation of VEGF and other angiogenic factors under hypoxia. | MicroRNAs (miRNAs) are a class of 20-24 nt non-coding RNAs that regulate gene expression primarily through post-transcriptional repression or mRNA degradation in a sequence-specific manner. The roles of miRNAs are just beginning to be understood, but the study of miRNA function has been limited by poor understanding of... | ["3' Untranslated Regions", 'Angiogenic Proteins', 'Base Sequence', 'Binding Sites', 'Cell Hypoxia', 'Cell Line, Tumor', 'Down-Regulation', 'Humans', 'MicroRNAs', 'Molecular Sequence Data', 'Neovascularization, Physiologic', 'Nucleic Acid Conformation', 'RNA, Small Interfering', 'Sequence Homology, Nucleic Acid', 'Tran... | 17,205,120 | [['D13.444.735.544.875.880', 'D13.444.735.790.878.880', 'G05.360.340.024.220.880.880', 'G05.360.340.024.340.137.910.880'], ['D12.644.276.100', 'D12.776.467.100', 'D23.529.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G02.111.570.120'], ['G03.197.300', 'G04.270.300'], ['A11.251.210.190', 'A11.251.8... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Novel Osteogenic Ti-6Al-4V Device For Restoration Of Dental Function In Patients With Large Bone Deficiencies: Design, Development And Implementation. | Custom devices supporting bone regeneration and implant placement are needed for edentulous patients with large mandibular deficiencies where endosteal implantation is not possible. We developed a novel subperiosteal titanium-aluminum-vanadium bone onlay device produced by additive manufacturing (AM) and post-fabricati... | ['Animals', 'Biocompatible Materials', 'Bone Screws', 'Cell Line', 'Dental Implants', 'Equipment Design', 'Humans', 'Male', 'Osseointegration', 'Osteoblasts', 'Osteogenesis', 'Porosity', 'Rabbits', 'Rats', 'Rats, Nude', 'Rats, Sprague-Dawley', 'Skull', 'Surface Properties', 'Tibia', 'Titanium'] | 26,854,193 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['E07.695.370.437', 'E07.858.442.660.460.437', 'E07.858.690.725.460.437'], ['A11.251.210'], ['D25.339.312', 'E06.780.346.593', 'E07.695.185', 'J01.637.051.339.312'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.427.213.140.570', 'G1... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Comparison of PCR-ELISA and galactomannan detection for the diagnosis of invasive aspergillosis. | AIM: To compare PCR with galactomannan antigen detection for the diagnosis of invasive aspergillosis (IA).METHODS: We prospectively collected serial blood samples from haematological patients at risk of IA, and analysed their samples retrospectively for galactomannan (GM) antigen using the Platelia test and for aspergi... | ['Adolescent', 'Adult', 'Aged', 'Animals', 'Antigens, Fungal', 'Aspergillosis', 'Aspergillus', 'Child, Preschool', 'Enzyme-Linked Immunosorbent Assay', 'False Positive Reactions', 'Female', 'Humans', 'Male', 'Mannans', 'Middle Aged', 'Polymerase Chain Reaction', 'Reproducibility of Results', 'Sensitivity and Specificit... | 16,175,901 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050'], ['D23.050.202'], ['C01.150.703.080'], ['B01.300.381.081'], ['M01.060.406.448'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['E01.354.506'], ['B01.050.150.900.649.313.988.400.112... | ['Named Groups [M]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Identification of a novel and orally available benzimidazole derivative as an NPY Y5 receptor antagonist with in vivo efficacy. | Optimization of lead compound 2 is described, mainly focusing on modification at the C-2 position of the benzimidazole core. Replacement of the phenyl linker of 2 with saturated rings resulted in identification of compound 8b which combines high Y5 receptor binding affinity with a good ADME profile leading to in vivo e... | ['Administration, Oral', 'Animals', 'Benzimidazoles', 'Drug Design', 'Drug Stability', 'Humans', 'Inhibitory Concentration 50', 'Mice', 'Mice, Obese', 'Protein Binding', 'Receptors, Neuropeptide Y', 'Solubility', 'Structure-Activity Relationship'] | 23,025,998 | [['E02.319.267.100'], ['B01.050'], ['D03.633.100.103'], ['E05.290.500', 'H01.158.703.007.338.500', 'H01.181.466.338.500'], ['E05.916.330'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.940.350', 'G07.690.936.563'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505.500.550.530'... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
To fix or not to fix? The role of fibular fixation in distal shaft fractures of the leg. | BACKGROUND: The role of stabilisation of the fibula in distal two-bone fractures of the leg is controversial. Some studies indicate the need for fibular stabilisation in 43 AO fractures, but few studies consider the role of the fibula in 42 AO fractures. The aim of the current paper is to explain the role of stabilisat... | ['Adult', 'Aged', 'Aged, 80 and over', 'Bone Malalignment', 'Female', 'Fibula', 'Fracture Fixation, Internal', 'Fracture Healing', 'Fractures, Bone', 'Fractures, Malunited', 'Humans', 'Male', 'Middle Aged', 'Patient Selection', 'Radiography', 'Retrospective Studies', 'Tibial Fractures', 'Treatment Outcome'] | 24,129,327 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C05.116.214'], ['A02.835.232.043.650.321'], ['E04.555.300.300'], ['G16.762.891.500'], ['C26.404'], ['C26.404.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.581.500.653', 'N04.590.731'], ['E01.370.350.700'], ['E05.318.3... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The immunogenicity and safety of a tetravalent measles-mumps-rubella-varicella vaccine when co-administered with conjugated meningococcal C vaccine to healthy children: A phase IIIb, randomized, multi-center study in Italy. | INTRODUCTION: Multiple vaccination visits and administrations can be stressful for infants, parents and healthcare providers. Multivalent combination vaccines can deliver the required number of antigens in fewer injections and clinic visits, while vaccine co-administration can also reduce the number of visits. This non... | ['Antibodies, Viral', 'Chickenpox Vaccine', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Fever', 'Healthy Volunteers', 'Herpesvirus 3, Human', 'Humans', 'Immunization Schedule', 'Immunogenicity, Vaccine', 'Infant', 'Italy', 'Male', 'Measles virus', 'Measles-Mumps-Rubella Vaccine', 'Meningococcal Infections', 'Mening... | 27,423,382 | [['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['D20.215.894.899.290.130'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['C23.888.119.344'], ['M01.774.500', 'M01.955.236'], ['B04.280.382.100.900.460... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
[A case of hypereosinophilic syndrome exhibiting left ventricular systolic dysfunction]. | A 16-year-old woman suffering from bronchial asthma since 2 years previously was admitted to the hospital because of high grade fever, dyspnea, skin eruption and arthralgia. Laboratory data revealed pronounced eosinophilia with elevated immunoglobulin E value. A chest X-ray film showed cardiomegaly with pulmonary conge... | ['Adolescent', 'Adrenal Cortex Hormones', 'Cardiomyopathy, Dilated', 'Eosinophilia', 'Female', 'Humans', 'Myocarditis', 'Systole', 'Ventricular Function, Left'] | 1,439,277 | [['M01.060.057'], ['D06.472.040'], ['C14.280.195.160', 'C14.280.238.070', 'C16.320.488.750'], ['C15.378.553.231'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.238.625'], ['G09.330.580.880', 'G11.427.494.570.880'], ['G09.330.955.800']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Focal Adhesions Undergo Longitudinal Splitting into Fixed-Width Units. | Focal adhesions (FAs) and stress fibers (SFs) act in concert during cell motility and in response to the extracellular environment. Although the structures of mature FAs and SFs are well studied, less is known about how they assemble and mature de novo during initial cell spreading. In this study using live-cell Airysc... | ['Cell Adhesion', 'Cell Line, Tumor', 'Cell Movement', 'Focal Adhesions', 'Humans', 'Stress Fibers'] | 29,910,076 | [['G04.022'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['A11.284.149.165.165.285'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.430.214.190.750.050.830']] | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bradycardia during methadone therapy in an infant. | OBJECTIVES: To report the occurrence of bradycardia associated with the use of methadone administered to prevent withdrawal in an infant with physical tolerance following long-term opioid therapy in the pediatric intensive care unit setting.DESIGN: Retrospective case report.PATIENTS AND RESULTS: Methadone (0.1 mg/kg) w... | ['Analgesics, Opioid', 'Anesthetics, Intravenous', 'Bradycardia', 'Fentanyl', 'Humans', 'Infant', 'Male', 'Methadone', 'Substance Withdrawal Syndrome', 'Ventilator Weaning'] | 16,395,081 | [['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['D27.505.696.277.100.035.075', 'D27.505.954.427.210.100.035.075'], ['C14.280.067.319', 'C23.550.073.300'], ['D03.383.621.265'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703']... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Indicators for elevated risk of human exposure to host-seeking adults of the Rocky Mountain wood tick (Dermacentor andersoni) in Colorado. | The human-biting adult stage of the Rocky Mountain wood tick (Dermacentor andersoni) can cause tick paralysis in humans and domestic animals and is the primary tick vector in the intermountain west of the pathogens causing Colorado tick fever, Rocky Mountain spotted fever, and tularemia. We conducted drag sampling stud... | ['Altitude', 'Animals', 'Bites and Stings', 'Colorado', 'Dermacentor', 'Ecology', 'Host-Parasite Interactions', 'Humans', 'Risk Factors', 'Tick Infestations'] | 18,697,314 | [['G16.500.275.058', 'N06.230.058'], ['B01.050'], ['C25.723.127', 'C26.176'], ['Z01.107.567.875.760.210'], ['B01.050.500.131.166.132.832.400.200'], ['H01.158.273.248', 'H01.277.249'], ['G16.527.200.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.75... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Effect of fosinopril treatment on serum C-reactive protein levels in patients with microalbuminuria. | Inflammation is an important factor in the development and progression of atherosclerosis. Observational studies have suggested that renin-angiotensin system inhibition might lower C-reactive protein (CRP). The aim of this study was to test the hypothesis that angiotensin-converting enzyme inhibition with fosinopril wo... | ['Albuminuria', 'Angiotensin II', 'Angiotensin-Converting Enzyme Inhibitors', 'C-Reactive Protein', 'Double-Blind Method', 'Female', 'Fosinopril', 'Humans', 'Inflammation', 'Male', 'Middle Aged', 'Odds Ratio', 'Renin-Angiotensin System', 'Sex Factors'] | 18,602,526 | [['C12.777.934.734.269', 'C13.351.968.934.734.269', 'C23.888.942.750.269'], ['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['D27.505.519.389.745.085'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['E0... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Role of processing speed and premorbid IQ on visual recognition in patients with schizophrenia. | Previous research had shown that processing speed and premorbid IQ are predictors of verbal-memory efficiency in patients with schizophrenia. We investigated whether the same factors are involved in visual memory. A total of 49 patients with schizophrenia and 43 healthy controls were administered a picture recognition ... | ['Adult', 'Female', 'Humans', 'Intelligence', 'Intelligence Tests', 'Male', 'Middle Aged', 'Neuropsychological Tests', 'Pattern Recognition, Visual', 'Photic Stimulation', 'Reaction Time', 'Recognition, Psychology', 'Regression Analysis', 'Schizophrenia', 'Schizophrenic Psychology', 'Young Adult'] | 18,608,649 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.752.543'], ['F04.711.141.493'], ['M01.060.116.630'], ['F04.711.513'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['E05.723.729'], ['E05.796.817', 'F02.830.650', 'F04.669.817', 'G11.561.677'], ['F02.463.425.540.706'], ['E05.318.740.750', 'N05.... | ['Named Groups [M]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
SmtB is a metal-dependent repressor of the cyanobacterial metallothionein gene smtA: identification of a Zn inhibited DNA-protein complex. | The smt locus of Synechococcus PCC 7942 contains a metal-regulated gene (smtA), which encodes a class II metallothionein, and a divergently transcribed gene, smtB, which encodes a repressor of smtA transcription. Regions containing cis-acting elements required for efficient induction, and required for smtB-dependent re... | ['Amino Acid Sequence', 'Bacterial Proteins', 'Base Sequence', 'Cyanobacteria', 'DNA-Binding Proteins', 'Metallothionein', 'Molecular Sequence Data', 'Operator Regions, Genetic', 'Promoter Regions, Genetic', 'Repressor Proteins', 'Sequence Deletion', 'Sequence Homology, Amino Acid', 'Zinc', 'beta-Galactosidase'] | 8,451,191 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.776.097'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B03.280', 'B03.440.475.100'], ['D12.776.260'], ['D12.776.556.670'], ['L01.453.245.667'], ['G02.111.570.080.689.650', 'G05.360.080.689.650', 'G05.360.340.024.686.645', 'G05.360.340.358.207.500.645']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Oxidative stress responses in the animal model, Daphnia pulex exposed to a natural bloom extract versus artificial cyanotoxin mixtures. | In the natural environment, Daphnia spp. are constantly exposed to a complex matrix of biomolecules, especially during cyanobacterial bloom events. When cyanobacterial cells decay, not only are toxic secondary metabolites known as cyanotoxins released, but also multiple other secondary metabolites, some of which act as... | ['Alkaloids', 'Animals', 'Bacterial Toxins', 'Chromatography, High Pressure Liquid', 'Cyanobacteria', 'Daphnia', 'Hydrogen Peroxide', 'Lipid Peroxidation', 'Microcystins', 'Models, Animal', 'Oxidative Stress', 'Tandem Mass Spectrometry', 'Toxins, Biological', 'Uracil'] | 27,614,285 | [['D03.132'], ['B01.050'], ['D23.946.123'], ['E05.196.181.400.300'], ['B03.280', 'B03.440.475.100'], ['B01.050.500.131.365.150.200'], ['D01.248.497.158.685.750.424', 'D01.339.431.374.424', 'D01.650.550.750.400', 'D02.389.338.253'], ['G02.111.515', 'G03.295.531.587'], ['D04.345.566.447', 'D12.644.641.447', 'D23.946.123.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Stimulation of spermatogenesis in stalk-sectioned rhesus monkeys by testosterone alone. | Testosterone alone stimulated spermatogenesis in four adult, pituitary stalk-sectioned rhesus monkeys. Ten to 14 weeks after transection of the pituitary stalk, testicular volumes declined to about one fifth of the presurgical values. Serum LH levels declined precipitously, being undetectable 1 week postsurgery, and se... | ['Animals', 'Estradiol', 'Hypophysectomy', 'Luteinizing Hormone', 'Macaca mulatta', 'Male', 'Prolactin', 'Radioimmunoassay', 'Sperm Count', 'Spermatogenesis', 'Testis', 'Testosterone'] | 6,853,673 | [['B01.050'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['E04.270.532', 'E04.525.400'], ['D06.472.699.322.576.463', 'D06.472.699.631.525.343.463', 'D12.644.548.691.525.343.463'], ['B01.050.150.900.649.313.988.400.112.199.120.510.550'], ['D06.472.699.322.576.773', 'D06.472.699.631.525.525', 'D12.644.548.69... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Assessing risk of falling in older adults. | Falls by older people present serious problems in every society. The purpose of this study was to investigate the role of a checklist in estimation and reduction of the risk for falls for older adults in Taiwan. Following literature review, a purposive sample was used in a cross-sectional design to assess risk factors ... | ['Accidental Falls', 'Activities of Daily Living', 'Aged', 'Aged, 80 and over', 'Chi-Square Distribution', 'Cross-Sectional Studies', 'Female', 'Geriatric Assessment', 'Geriatric Nursing', 'Health Facility Environment', 'Housing for the Elderly', 'Humans', 'Logistic Models', 'Male', 'Nursing Assessment', 'Nursing Evalu... | 12,930,464 | [['N06.850.135.122'], ['E02.760.169.063.500.067', 'E02.831.067', 'I03.050', 'N02.421.784.110'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['E05... | ['Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [... | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 1 |
Permeabilization of the plasma membrane by deletion mutants of diphtheria toxin. | Diphtheria toxin B-fragment binds to cell-surface receptors and facilitates translocation of the enzymatically active A-fragment to the cytosol. In this process the B-fragment inserts into the plasma membrane and induces formation of cation-selective channels. We examined the ability of a number of diphtheria toxin-der... | ['Animals', 'Cell Membrane Permeability', 'Diphtheria Toxin', 'Hydrogen-Ion Concentration', 'Ion Channels', 'Kinetics', 'L Cells', 'Mutation', 'Peptide Fragments', 'Protein Biosynthesis', 'Sodium', 'Vero Cells'] | 2,479,538 | [['B01.050'], ['G03.143.335', 'G04.175'], ['D08.811.913.400.725.115.220', 'D23.946.123.305'], ['G02.300'], ['D12.776.157.530.400', 'D12.776.543.550.450', 'D12.776.543.585.400'], ['G01.374.661', 'G02.111.490'], ['A11.251.210.505', 'A11.329.228.505'], ['G05.365.590'], ['D12.644.541'], ['G02.111.660.871', 'G03.734.871', '... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Pathological gambling induced by dopamine antagonists: a case report. | Pathological gambling is defined as inappropriate, persistent, and maladaptive gambling behaviour. It is a non-pharmacological addiction classified as an impulse control disorder. However, pathological gambling has been associated with dopamine agonist use. Here we report of a 28-year-old man with a first major depress... | ['Adult', 'Behavior, Addictive', 'Depressive Disorder, Major', 'Dopamine Antagonists', 'Flupenthixol', 'Gambling', 'Humans', 'Male', 'Stress Disorders, Post-Traumatic'] | 24,356,928 | [['M01.060.116'], ['F01.145.527.100.120'], ['F03.600.300.375'], ['D27.505.519.625.150.175', 'D27.505.696.577.150.175'], ['D02.886.952.360', 'D03.383.606.460', 'D03.633.300.953.704.360'], ['F01.145.722.408', 'F03.250.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F03.950.750.500']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Bi-allelic Pro291Leu variant in KCNQ4 leads to early onset non-syndromic hearing loss. | Variants of KCNQ4 are one of the most common causes of dominantly inherited nonsyndromic hearing loss. We investigated a consanguineous family in which two individuals had prelignual hearing loss, apparently inherited in a recessive mode. Whole-exome sequencing analyses demonstrated genetic heterogeneity as variants in... | ['Age of Onset', 'Consanguinity', 'Deafness', 'Female', 'Genetic Heterogeneity', 'Genetic Predisposition to Disease', 'Humans', 'KCNQ Potassium Channels', 'Leucine', 'Male', 'Mutation, Missense', 'Pedigree', 'Proline', 'Whole Exome Sequencing'] | 31,028,865 | [['N05.715.350.075.100', 'N06.850.490.250.100'], ['G05.090.403.180', 'G05.180'], ['C09.218.458.341.186', 'C10.597.751.418.341.186', 'C23.888.592.763.393.341.186'], ['G05.365.331'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.157.530.400.600.900.124.249', 'D12.776.5... | ['Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
New guidelines on ethical considerations in HIV preventive vaccine research. | In March 2000, UNAIDS released annotated guidance points on the ethical considerations of HIV vaccine research (the "Guidance Document"). The guidance points, reproduced at the end of the article, are the product of two years' consultation and debate around the world, yet key questions remain unsettled. This article re... | ['AIDS Vaccines', 'Ethics, Medical', 'Guidelines as Topic', 'HIV Infections', 'Humans'] | 11,833,190 | [['D20.215.894.899.050'], ['K01.752.566.479.171.132.750', 'N05.350.340.162.500'], ['N04.761.700.350', 'N05.700.350'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B01.050.150.900.649.313.988.400.112.400.400']] | ['Chemicals and Drugs [D]', 'Humanities [K]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Why do some Fischer indolizations fail? | The mechanisms of the Fischer indole synthesis and competing cleavage pathways were explored with SCS-MP2/6-31G(d) and aqueous solvation calculations. Electron-donating substituents divert the reaction pathway to heterolytic N-N bond cleavage and preclude the acid-promoted [3,3]-sigmatropic rearrangement. | ['Indoles', 'Models, Molecular', 'Thermodynamics'] | 21,443,189 | [['D03.633.100.473'], ['E05.599.595'], ['G01.906']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Primaparas' perceptions of their delivery experience and their maternal-infant interactions: compared according to delivery method]. | One of the important tasks for new parents, especially mothers, is to establish warm, mutually affirming interpersonal relationships with the new baby in the family, with the purpose of promoting the healthy development of the child and the wellbeing of the whole family. Nurses assess the quality of the behavioral char... | ['Cesarean Section', 'Delivery, Obstetric', 'Female', 'Humans', 'Infant, Newborn', 'Labor, Obstetric', 'Mother-Child Relations', 'Obstetric Nursing', 'Pregnancy'] | 2,232,441 | [['E04.520.252.500'], ['E04.520.252'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['G08.686.784.769.326'], ['F01.829.263.370.290.170'], ['H02.478.676.570', 'N02.421.533.571'], ['G08.686.784.769']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Excessive vomiting abolished by carotid denervation. | The carotid sinus syndrome (CSS) is characterized by repetitive syncope due to prolonged heart rate slowing or a profound drop in systolic blood pressure. CSS is due to an inappropriate response of a hypersensitive carotid sinus following pressure on or stretching of the neck. We report on a patient with excessive gagg... | ['Baroreflex', 'Bradycardia', 'Carotid Sinus', 'Denervation', 'Female', 'Glossopharyngeal Nerve', 'Humans', 'Middle Aged', 'Nausea', 'Neurosurgical Procedures', 'Reflex, Abnormal', 'Syncope', 'Treatment Outcome', 'Vagus Nerve', 'Visceral Afferents', 'Vomiting'] | 17,291,834 | [['G09.330.380.057', 'G11.561.731.063'], ['C14.280.067.319', 'C23.550.073.300'], ['A07.015.114.186.456'], ['E04.525.210'], ['A08.800.050.050.337', 'A08.800.050.600.387', 'A08.800.800.060.337', 'A08.800.800.120.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C23.888.821.712'], ['E04.525'],... | ['Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Inhibition of cholesterol esterification in rabbit aorta by prostaglandin E2. | Cholesterol esterification in the arterial wall was investigated with cell-free preparations of intima-media from control rabbits and rabbits rendered atherosclerotic by feeding a diet containing 1% cholesterol. In the presence of 2 mM ATP and 0.1 mM CoA, the major activity for esterification of [4-14C] cholesterol add... | ['Animals', 'Aorta', 'Aorta, Thoracic', 'Aortic Diseases', 'Arteriosclerosis', 'Cholesterol', 'Cholesterol Esters', 'Diet, Atherogenic', 'Male', 'Prostaglandins E', 'Rabbits', 'Subcellular Fractions'] | 901,619 | [['B01.050'], ['A07.015.114.056'], ['A07.015.114.056.372'], ['C14.907.109'], ['C14.907.137.126'], ['D04.210.500.247.222.284', 'D04.210.500.247.808.197', 'D10.570.938.208'], ['D04.210.500.247.222.284.200', 'D04.210.500.247.808.197.200', 'D10.570.938.208.250'], ['G07.203.650.240.242'], ['D10.251.355.255.550.250', 'D23.46... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fluorometric characterization of dityrosine: complex formation with boric acid and borate ion. | Borate/boric acid solutions have distinctive effects on the absorption and fluorescence emission spectra of dityrosine. In the presence of excess borate/boric acid, the fluorescence emission maximum of the singly ionized dityrosine chromophore shifts from 407 nm (quantum yield = 0.80) to 374 nm (quantum yield = 0.14). ... | ['Borates', 'Boric Acids', 'Hydrogen-Ion Concentration', 'Kinetics', 'Mathematics', 'Models, Theoretical', 'Quantum Theory', 'Solutions', 'Spectrometry, Fluorescence', 'Spectrophotometry, Ultraviolet', 'Tyrosine'] | 2,069,580 | [['D01.132.250.075', 'D01.248.497.158.076', 'D02.203.130.075'], ['D01.029.260.093', 'D01.132.250', 'D02.203.130'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['H01.548'], ['E05.599'], ['H01.671.579.800'], ['D26.776'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['E05.196.712.726.802', 'E05.196.867.826.802'], ['D1... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Sodium hydrosulfide alleviates lung inflammation and cell apoptosis following resuscitated hemorrhagic shock in rats. | AIM: To investigate the protective effects of hydrogen sulfide (H2S) against inflammation, oxidative stress and apoptosis in a rat model of resuscitated hemorrhagic shock.METHODS: Hemorrhagic shock was induced in adult male SD rats by drawing blood from the femoral artery for 10 min. The mean arterial pressure was main... | ['Animals', 'Apoptosis', 'Bronchoalveolar Lavage Fluid', 'Male', 'Pneumonia', 'Rats', 'Rats, Sprague-Dawley', 'Resuscitation', 'Shock, Hemorrhagic', 'Sulfides'] | 24,122,010 | [['B01.050'], ['G04.146.954.035'], ['E05.927.100.500'], ['C01.748.610', 'C08.381.677', 'C08.730.610'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.750'], ['E02.365.647'], ['C23.550.414.980', 'C23.550.835.650'], ['D01.248.497.158.874', 'D01.875.350.850', 'D02.886.520']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Peripheral muscle weakness and exercise capacity in children with cystic fibrosis. | Exercise intolerance in cystic fibrosis (CF) is attributed to diminished nutritional and pulmonary function. We studied the pathophysiology of such intolerance in relation to muscle force and fat-free mass (FFM), in 15 children with moderately severe symptoms of CF (FEV1 < 80% predicted and/or weight for age < -1 SD of... | ['Adolescent', 'Anthropometry', 'Body Mass Index', 'Child', 'Cystic Fibrosis', 'Exercise Test', 'Exercise Tolerance', 'Forced Expiratory Volume', 'Humans', 'Maximal Voluntary Ventilation', 'Muscle Contraction', 'Muscle, Skeletal', 'Oxygen Consumption'] | 10,051,246 | [['M01.060.057'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['M01.060.406'], ['C06.689.202', 'C08.381.187', 'C16.320.190', 'C16.614.213'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['G11.427.6... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A comparison of the laryngeal mask and tracheal tube for controlled ventilation. | The use of laryngeal mask airway (LMA), size 3 or 4, and endotracheal tube (ETT) 8.0 mm was studied comparatively to determine the adequacy of respiratory function during positive pressure ventilation (PPV) by applying a series of given peak inspiratory pressures (PIPs) of 10.0, 12.5, 15.0, 17.5, 20.0 and 30.0 cm H2O. ... | ['Female', 'Humans', 'Intubation, Intratracheal', 'Laryngeal Masks', 'Lung', 'Male', 'Positive-Pressure Respiration', 'Respiration, Artificial', 'Respiratory Function Tests'] | 8,869,675 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.041.500', 'E02.585.578', 'E05.497.578'], ['E02.041.500.475', 'E02.585.578.475', 'E05.497.578.475', 'E07.700.500.450', 'J01.637.708.560.782.450'], ['A04.411'], ['E02.041.625.790', 'E02.880.820.790'], ['E02.041.625', 'E02.365.647.729', 'E02.880.820'], ['E01.370.386.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
mTOR complex 1 regulates lipin 1 localization to control the SREBP pathway. | The nutrient- and growth factor-responsive kinase mTOR complex 1 (mTORC1) regulates many processes that control growth, including protein synthesis, autophagy, and lipogenesis. Through unknown mechanisms, mTORC1 promotes the function of SREBP, a master regulator of lipo- and sterolgenic gene transcription. Here, we dem... | ['Animals', 'Humans', 'Lipid Metabolism', 'Male', 'Mechanistic Target of Rapamycin Complex 1', 'Mice', 'Multiprotein Complexes', 'Nuclear Proteins', 'Phosphatidate Phosphatase', 'Proteins', 'Signal Transduction', 'Sterol Regulatory Element Binding Protein 1', 'Sterol Regulatory Element Binding Protein 2', 'TOR Serine-T... | 21,816,276 | [['B01.050'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.458'], ['D05.500.337', 'D08.811.913.696.620.682.700.931.500', 'D12.776.476.925.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['D05.500'], ['D12.776.660'], ['D08.811.277.352.650.620'], ['D12.776'], ['G02.111.820', 'G04.835'], ['D12.776.260.103.50... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Safety ensuring retinal prosthesis with precise charge balance and low power consumption. | Ensuring safe operation of stimulators is the most important issue in neural stimulation. Safety, in terms of stimulators' electrical performances, can be related mainly to two factors; the zero-net charge transfer to tissue and the heat generated by power dissipation at tissue. This paper presents a safety ensuring ne... | ['Electric Impedance', 'Electrical Equipment and Supplies', 'Equipment Design', 'Equipment Safety', 'Microelectrodes', 'Microtechnology', 'Visual Prosthesis'] | 24,681,924 | [['G01.358.500.249.277.350'], ['E07.305'], ['E05.320'], ['E05.330'], ['E07.305.250.500'], ['H01.570', 'J01.897.520.500'], ['E07.695.950']] | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
uPAR Expression Pattern in Patients with Urothelial Carcinoma of the Bladder--Possible Clinical Implications. | The objective of the present study was to confirm the expression and localisation pattern of the urokinase-type plasminogen activator receptor (uPAR) focusing on its possible clinical relevance in patients with urothelial neoplasia of the bladder. uPAR is a central molecule in tissue remodelling during cancer invasion ... | ['Adult', 'Aged', 'Biomarkers, Tumor', 'Female', 'Humans', 'Male', 'Middle Aged', 'Receptors, Urokinase Plasminogen Activator', 'Retrospective Studies', 'Urinary Bladder', 'Urinary Bladder Neoplasms', 'Urothelium'] | 26,292,086 | [['M01.060.116'], ['M01.060.116.100'], ['D23.101.140'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D12.776.395.550.448.813', 'D12.776.543.484.500.813', 'D12.776.543.550.418.813', 'D12.776.543.750.815'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Time course of changes in cerebral blood flow velocity after tourniquet deflation in patients with diabetes mellitus or previous stroke under sevoflurane anesthesia. | We observed an increase in mean middle cerebral artery blood flow velocity (V(mca)) after tourniquet deflation during orthopedic surgery under sevoflurane anesthesia in patients with diabetes mellitus or previous stroke. Eight controls, seven insulin-treated diabetic patients, and eight previous stroke patients were st... | ['Aged', 'Anesthesia, Inhalation', 'Anesthetics, Inhalation', 'Blood Flow Velocity', 'Blood Gas Analysis', 'Blood Pressure', 'Cerebrovascular Circulation', 'Consciousness Monitors', 'Diabetes Mellitus', 'Female', 'Heart Rate', 'Humans', 'Knee', 'Leg', 'Male', 'Methyl Ethers', 'Middle Aged', 'Middle Cerebral Artery', 'O... | 21,472,481 | [['M01.060.116.100'], ['E03.155.197.197'], ['D27.505.696.277.100.035.060', 'D27.505.954.427.210.100.035.060'], ['E01.370.370.130', 'G09.330.380.630.080'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G09.330.100.159'], ['E07.858.195'], ['C18.45... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Dietary protein digestion and absorption rates and the subsequent postprandial muscle protein synthetic response do not differ between young and elderly men. | Impaired digestion and/or absorption of dietary protein lowers postprandial plasma amino acid availability and, as such, could reduce the postprandial muscle protein synthetic response in the elderly. We aimed to compare in vivo dietary protein digestion and absorption and the subsequent postprandial muscle protein syn... | ['Aged', 'Aging', 'Amino Acids', 'Area Under Curve', 'Caseins', 'Dietary Proteins', 'Digestion', 'Humans', 'Insulin', 'Intestinal Absorption', 'Male', 'Middle Aged', 'Muscle Proteins', 'Postprandial Period', 'Young Adult'] | 19,625,697 | [['M01.060.116.100'], ['G07.345.124'], ['D12.125'], ['E05.318.740.200', 'G03.787.101', 'G07.690.725.064', 'N06.850.520.830.200'], ['D12.776.256.159.750.207', 'D12.776.744.150'], ['D12.776.256', 'G07.203.300.428', 'J02.500.428'], ['G07.203.650.250', 'G10.261.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D06.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Outbreak properties of epidemic models: the roles of temporal forcing and stochasticity on pathogen invasion dynamics. | Despite temporally forced transmission driving many infectious diseases, analytical insight into its role when combined with stochastic disease processes and non-linear transmission has received little attention. During disease outbreaks, however, the absence of saturation effects early on in well-mixed populations mea... | ['Animals', 'Basic Reproduction Number', 'Communicable Diseases', 'Disease Outbreaks', 'Disease Vectors', 'Humans', 'Models, Biological', 'Stochastic Processes'] | 21,094,169 | [['B01.050'], ['E05.318.308.985.525.080', 'N01.224.935.597.080', 'N06.850.335.125', 'N06.850.505.400.975.525.080', 'N06.850.520.308.985.525.080'], ['C01.221', 'C23.550.291.531'], ['N06.850.290'], ['N06.850.335.188', 'N06.850.520.203.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395'], ['E05.318.740.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Development of an acellular tumor extracellular matrix as a three-dimensional scaffold for tumor engineering. | Tumor engineering is defined as the construction of three-dimensional (3D) tumors in vitro with tissue engineering approaches. The present 3D scaffolds for tumor engineering have several limitations in terms of structure and function. To get an ideal 3D scaffold for tumor culture, A549 human pulmonary adenocarcinoma ce... | ['Animals', 'Biomechanical Phenomena', 'Cell Culture Techniques', 'Cell Line, Tumor', 'Cell Survival', 'Collagen', 'DNA, Neoplasm', 'Drug Combinations', 'Elastic Modulus', 'Extracellular Matrix', 'Glycosaminoglycans', 'Humans', 'Intercellular Signaling Peptides and Proteins', 'Laminin', 'MCF-7 Cells', 'Mice', 'Porosity... | 25,072,252 | [['B01.050'], ['G01.154.090', 'G01.374.089'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['D05.750.078.280', 'D12.776.860.300.250'], ['D13.444.308.425'], ['D26.310'], ['G01.374.590.605'], ['A11.284.295.310'], ['D09.698.373'], ['B01.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Random amplified polymorphic DNA and plasmid analyses used in investigation of an outbreak of multiresistant Klebsiella pneumoniae. | Multiresistant Klebsiella pneumoniae strains with plasmid-borne extended-spectrum beta-lactamases (ESBL) are increasingly frequent nosocomial pathogens. A major outbreak of clinical infections, mainly involving patients in the Newborn Services Unit with limited spread to adult patients, occurred at our hospital. This e... | ['Adult', 'Child', 'Cross Infection', 'DNA, Bacterial', 'Disease Outbreaks', 'Humans', 'Klebsiella Infections', 'Klebsiella pneumoniae', 'Microbial Sensitivity Tests', 'Phenotype', 'Plasmids', 'Polymerase Chain Reaction', 'Victoria', 'beta-Lactam Resistance'] | 7,751,382 | [['M01.060.116'], ['M01.060.406'], ['C01.248', 'C23.550.291.875.500'], ['D13.444.308.212'], ['N06.850.290'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.150.252.400.310.503'], ['B03.440.450.425.425.600', 'B03.660.250.150.400.590'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['G05.695'], [... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
ReAsH: another viable option for in vivo protein labelling in Dictyostelium. | Biarsenical-tetracysteine fluorescent protein tagging has been effectively used in a variety of cell types. It has the advantage of requiring a much smaller peptide alteration to existing proteins than fusion to green fluorescent protein (GFP) or monomeric red fluorescent protein (mRFP). However, there are no reports o... | ['Animals', 'Arsenicals', 'Contractile Proteins', 'Cysteine', 'Dictyostelium', 'Filamins', 'Fluoresceins', 'Fluorescence', 'Microfilament Proteins', 'Organometallic Compounds', 'Oxazines', 'Protozoan Proteins', 'Staining and Labeling'] | 19,335,452 | [['B01.050'], ['D01.075', 'D02.129'], ['D12.776.210'], ['D02.886.030.230', 'D02.886.489.155', 'D12.125.154.299', 'D12.125.166.230'], ['B01.046.550.200.300'], ['A11.284.430.214.190.750.050.414', 'D05.750.078.730.315', 'D12.776.210.249', 'D12.776.220.525.315'], ['D02.455.426.779.347', 'D03.633.300.953.275', 'D04.711.347'... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[New approach for unresectable primary liver cancer--intra-arterial combination chemotherapy during and after operation with local injection of ethanol]. | From 1976 to 1988, hepatic arterial infusion chemotherapy was performed in 52 patients with unresectable hepato-cellular carcinomas. Forty-nine (94%) out of 52 patients were stage III or stage IV. Thirty-five patients underwent continuous infusion of 5-FU and MMC employing chronometric infusion pumps. Mean survival of ... | ['Aged', 'Antineoplastic Combined Chemotherapy Protocols', 'Carcinoma, Hepatocellular', 'Combined Modality Therapy', 'Doxorubicin', 'Ethanol', 'Female', 'Fluorouracil', 'Hepatic Artery', 'Humans', 'Infusion Pumps', 'Infusions, Intra-Arterial', 'Injections', 'Intraoperative Care', 'Liver Neoplasms', 'Male', 'Middle Aged... | 2,551,220 | [['M01.060.116.100'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['E02.186'], ['D02.455.426.559.847.562.050.200.175', 'D04.615.562.050.200.175', 'D09.408.051.059.200.175'], ['D02.033.375'], ['D03.383.742.698.875.40... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Tumoral Presentation of Homonymous Hemianopia and Prosopagnosia in Cerebral Amyloid Angiopathy-Related Inflammation. | While cerebral amyloid angiopathy is a common cause of lobar hemorrhage, rarely it may be associated with an inflammatory response, thought to be incited by amyloid deposits. We report a 73-year-old woman with an extensive cancer history who presented with tumor-like lesions and symptoms of homonymous hemianopia and pr... | ['Adenocarcinoma', 'Adenocarcinoma of Lung', 'Aged', 'Biopsy', 'Cerebral Amyloid Angiopathy', 'Female', 'Hemianopsia', 'Humans', 'Lung Neoplasms', 'Magnetic Resonance Imaging', 'Positron-Emission Tomography', 'Prosopagnosia', 'Tomography, X-Ray Computed'] | 28,187,081 | [['C04.557.470.200.025'], ['C04.557.470.200.025.022', 'C04.588.894.797.520.055'], ['M01.060.116.100'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C10.228.140.300.510.200.200', 'C14.907.253.560.200.200', 'C18.452.845.50... | ['Diseases [C]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Amphotericin-induced heart-rate decrease in children. | We describe six children with acute decreases in heart rate temporally related to amphotericin B administration. All patients had achieved their maximal dose within 3 to 4 days. Heart-rate drops occurred as early as day 3 but could be delayed up to day 7 after start of therapy. The mean heart rate dropped from 104 +/- ... | ['Adolescent', 'Amphotericin B', 'Antifungal Agents', 'Case-Control Studies', 'Child', 'Child, Preschool', 'Female', 'Heart Rate', 'Humans', 'Male', 'Opportunistic Infections'] | 7,554,685 | [['M01.060.057'], ['D02.540.576.500.500'], ['D27.505.954.122.136'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.600.875.500', 'G09.330.380.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.597', 'C01.610.684', 'C01.925.597']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Gangliosides are essential endosomal receptors for quasi-enveloped and naked hepatitis A virus. | The Picornaviridae are a diverse family of positive-strand RNA viruses that includes numerous human and veterinary pathogens1. Among these, hepatitis A virus (HAV), a common cause of acute hepatitis in humans, is unique in that it is hepatotropic and is released from hepatocytes without lysis in small vesicles that res... | ['Capsid', 'Capsid Proteins', 'Cell Line', 'Endocytosis', 'Endosomes', 'Exosomes', 'Gangliosides', 'Gene Knockout Techniques', 'Genome, Viral', 'HeLa Cells', 'Hepatitis A virus', 'Hepatocytes', 'Humans', 'Lysosome-Associated Membrane Glycoproteins', 'Lysosomes', 'Neoplasm Proteins', 'Virion', 'Virus Internalization'] | 32,451,473 | [['A21.249.500.250'], ['D12.776.964.970.600.550'], ['A11.251.210'], ['G04.417'], ['A11.284.430.214.190.875.190.880.337'], ['A11.284.295.588.750', 'A11.284.430.214.190.875.190.880.495'], ['D09.400.410.420.025.475', 'D10.390.470.025.475', 'D10.570.877.360.025.475'], ['E05.393.335.750'], ['G05.360.340.358.840'], ['A11.251... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Immunohistochemical observations of keratins, involucrin, and epithelial membrane antigen in urinary bladder carcinomas from patients infected with Schistosoma haematobium. | Squamous cell carcinomas of the urinary bladder and the epithelial lesions associated with infection by Schistosoma haematobium were histopathologically and immunohistochemically described for keratin proteins (TK, 41-65 kDa; KL1, 55-57 kDa; PKK1, 40, 45 and 52.5 kDa), involucrin, and epithelial membrane antigen (EMA).... | ['Adult', 'Aged', 'Carcinoma, Squamous Cell', 'Female', 'Histocytochemistry', 'Humans', 'Immunochemistry', 'Keratins', 'Male', 'Membrane Proteins', 'Middle Aged', 'Mucin-1', 'Protein Precursors', 'Schistosomiasis haematobia', 'Urinary Bladder Neoplasms'] | 2,440,175 | [['M01.060.116'], ['M01.060.116.100'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H01.158.201.486', 'H01.181.122.605'... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
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