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Conserved Glu-47 and Lys-50 residues are critical for UDP-N | Nucleotide sugar transporters (NSTs) regulate the flux of activated sugars from the cytosol into the lumen of the Golgi apparatus where glycosyltransferases use them for the modification of proteins, lipids, and proteoglycans. It has been well-established that NSTs are antiporters that exchange nucleotide sugars with t... | ['Amino Acid Sequence', 'Animals', 'Glutamic Acid', 'Golgi Apparatus', 'Ion Transport', 'Lysine', 'Mice', 'Models, Molecular', 'Protein Conformation', 'Sequence Homology', 'Sodium-Phosphate Cotransporter Proteins, Type IIc', 'Uridine Diphosphate N-Acetylglucosamine', 'Uridine Monophosphate'] | 31,118,275 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['A11.284.430.214.190.875.336'], ['G03.143.500'], ['D12.125.068.555', 'D12.125.095.647', 'D12.125.142.497'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.595'], ['G02.111.570.820.709'],... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Nanoparticle (star polymer) delivery of nitric oxide effectively negates Pseudomonas aeruginosa biofilm formation. | Biofilms are increasingly recognized as playing a major role in human infectious diseases, as they can form on both living tissues and abiotic surfaces, with serious implications for applications that rely on prolonged exposure to the body such as implantable biomedical devices or catheters. Therefore, there is an urge... | ['Anti-Bacterial Agents', 'Biofilms', 'Drug Carriers', 'Kinetics', 'Methacrylates', 'Microbial Sensitivity Tests', 'Nanoparticles', 'Nitric Oxide', 'Polyethylenes', 'Polymerization', 'Pseudomonas aeruginosa', 'Spectroscopy, Fourier Transform Infrared'] | 24,915,286 | [['D27.505.954.122.085'], ['A20.593', 'G06.120'], ['D26.255.260', 'E02.319.300.380'], ['G01.374.661', 'G02.111.490'], ['D02.241.081.069.600'], ['E01.370.225.875.595', 'E05.200.875.595', 'E05.337.550.400'], ['J01.637.512.600'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550.587.600'], ['D02.455.326.2... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Resistance to Melampsora larici-epitea leaf rust in Salix: analyses of quantitative trait loci. | Quantitative resistance of Salix to Melampsora larici-epitea leaf rust was studied in 2 Salix mapping populations. One population was a backcross between a S. schwerinii x S. viminalis hybrid and S. viminalis, and the other was an F2 population between S. viminalis and S. dasyclados. A leaf disc bioassay was used to st... | ['Basidiomycota', 'Immunity, Innate', 'Plant Diseases', 'Plant Leaves', 'Quantitative Trait Loci', 'Salix'] | 19,029,679 | [['B01.300.179'], ['G12.450.564'], ['G15.610'], ['A18.024.812'], ['G05.360.340.024.380.937'], ['B01.650.940.800.575.912.250.859.797.875.833']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Muscle recruitment variations during wrist flexion exercise: MR evaluation. | OBJECTIVE: Many exercise protocols used in physiological studies assume homogeneous and diffuse muscle recruitment. To test this assumption during a "standard" wrist flexion protocol, variations in muscle recruitment were assessed using MRI in eight healthy subjects.MATERIALS AND METHODS: Variations were assessed by co... | ['Female', 'Humans', 'Magnetic Resonance Imaging', 'Male', 'Muscles', 'Physical Exertion', 'Pronation', 'Supination', 'Wrist Joint'] | 8,188,915 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.825.500'], ['A02.633', 'A10.690'], ['G11.427.683'], ['G11.427.410.698.840'], ['G11.427.410.698.920'], ['A02.835.583.405.930']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of sodium hypochlorite on typical biofilms formed in drinking water distribution systems. | Human health and biological safety problems resulting from urban drinking water pipe network biofilms pollution have attracted wide concern. Despite the inclusion of residual chlorine in drinking water distribution systems supplies, the bacterium is a recalcitrant human pathogen capable of forming biofilms on pipe wall... | ['Bacteria', 'Bacterial Physiological Phenomena', 'Biofilms', 'Disinfectants', 'Disinfection', 'Drinking Water', 'Flavobacterium', 'Klebsiella', 'Pseudomonas', 'Sodium Hypochlorite', 'Sphingomonas', 'Water Purification', 'Water Supply'] | 28,362,303 | [['B03'], ['G06.099'], ['A20.593', 'G06.120'], ['D27.505.954.122.425', 'D27.720.274'], ['N06.850.780.200.450.850.375'], ['D01.045.250.875.300', 'D01.248.497.158.459.650.300', 'D01.650.550.925.199', 'G07.203.100.418', 'J02.200.418'], ['B03.440.080.190.250', 'B03.440.400.425.310.250'], ['B03.440.450.425.425', 'B03.660.25... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Comparison of ampicillin plus gentamicin vs. penicillin plus gentamicin in empiric treatment of neonates at risk of early onset sepsis. | AIM: We aimed to compare the clinical efficacy of ampicillin (AMP) vs. penicillin (PEN) both combined with gentamicin in the empirical treatment of neonates at risk of early onset neonatal sepsis (EOS).METHODS: We performed an open label cluster randomized equivalence study in both Estonian neonatal intensive care unit... | ['Age of Onset', 'Ampicillin', 'Anti-Bacterial Agents', 'Drug Therapy, Combination', 'Estonia', 'Female', 'Gentamicins', 'Humans', 'Infant, Newborn', 'Intensive Care Units, Neonatal', 'Intestines', 'Kaplan-Meier Estimate', 'Male', 'Penicillins', 'Prospective Studies', 'Risk Factors', 'Sepsis', 'Treatment Outcome'] | 20,096,030 | [['N05.715.350.075.100', 'N06.850.490.250.100'], ['D02.065.589.099.750.750.050', 'D02.886.108.750.750.050', 'D03.633.100.300.750.750.050'], ['D27.505.954.122.085'], ['E02.319.310'], ['Z01.542.248.136.360'], ['D09.408.051.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['N02.278.388.493.390.... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Impaired concentration due to frontal lobe damage from two distinct lesion sites. | BACKGROUND: Investigations of cognitive deficits after frontal lobe damage have commonly relied on multidimensional tests and relatively coarse specification of lesion anatomy. Some form of impairment in attention is often asserted to cause the revealed deficits.OBJECTIVE: To describe a disorder of attention in patient... | ['Adult', 'Aged', 'Attention', 'Brain Damage, Chronic', 'Brain Injuries', 'Brain Neoplasms', 'Cerebral Hemorrhage', 'Cerebral Infarction', 'Cognition', 'Cognition Disorders', 'Corpus Callosum', 'Female', 'Frontal Lobe', 'Functional Laterality', 'Humans', 'Male', 'Middle Aged', 'Neural Pathways', 'Neuropsychological Tes... | 16,116,118 | [['M01.060.116'], ['M01.060.116.100'], ['F02.830.104.214'], ['C10.228.140.140'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['C04.588.614.250.195', 'C10.228.140.211', 'C10.551.240.250'], ['C10.228.140.300.535.200', 'C14.907.253.573.200', 'C23.550.414.913.100'], ['C10.228.140.300.150.477.200', 'C10.228.1... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Scedosporium prolificans sclerokeratitis. | BACKGROUND: The fungus Scedosporium prolificans was first described as a human pathogen in 1984, and has been associated with metastatic endophthalmitis and one previously reported case of sclerokeratitis.METHODS: We report a case of S. prolificans sclerokeratitis in the setting of late scleral necrosis complicating pt... | ['Aged', 'Anti-Bacterial Agents', 'Drug Therapy, Combination', 'Eye Enucleation', 'Eye Infections, Fungal', 'Humans', 'Keratitis', 'Male', 'Mycetoma', 'Necrosis', 'Postoperative Complications', 'Pterygium', 'Scleritis'] | 7,818,880 | [['M01.060.116.100'], ['D27.505.954.122.085'], ['E02.319.310'], ['E04.540.429'], ['C01.150.703.320', 'C01.375.450', 'C11.294.450'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.204.564'], ['C01.150.252.410.040.692.500', 'C01.150.252.819.557', 'C01.150.703.302.500', 'C01.800.200.500', 'C01.800.720.557', 'C17.8... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
MACC1 down-regulation inhibits proliferation and tumourigenicity of nasopharyngeal carcinoma cells through Akt/â-catenin signaling pathway. | The present study was aimed at investigating the expression of metastasis-associated in colon cancer 1 (MACC1) in nasopharyngeal carcinoma (NPC), its relationship with â-catenin, Met expression and the clinicopathological features of NPC, and its roles in carcinogenesis of NPC. Our results showed that MACC1 expression ... | ['Adolescent', 'Adult', 'Aged', 'Apoptosis', 'Carcinoma', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Cell Transformation, Neoplastic', 'Child', 'Down-Regulation', 'Female', 'Humans', 'Male', 'Middle Aged', 'Nasopharyngeal Neoplasms', 'Proto-Oncogene Proteins c-akt', 'Trans-Activators', 'Transcription F... | 23,573,286 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['G04.146.954.035'], ['C04.557.470.200'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.198', 'G07.568.500.180'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.697.098.500', 'C23.550.727.098.500'], ['M01.060.406'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937']... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Body mass index and health among Union Army veterans: 1891-1905. | This paper explores the relationship between BMI and several health conditions among Union Army veterans who had medical examinations between 1891 and 1905. We find that BMI, when used as a proxy of nutrition, helps to explain morbidity and mortality differentials among veterans. There is evidence suggesting that among... | ['Adult', 'Aged', 'Body Mass Index', 'Disability Evaluation', 'Health Status', 'History, 19th Century', 'History, 20th Century', 'Humans', 'Longitudinal Studies', 'Male', 'Middle Aged', 'Morbidity', 'Mortality', 'Nutritional Status', 'Veterans'] | 16,046,203 | [['M01.060.116'], ['M01.060.116.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['E01.370.400'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['K01.400.504.937'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.50... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Receptor binding and internalization of a unique biologically active angiotensin II-colloidal gold conjugate: morphological analysis of angiotensin II processing in isolated vascular strips. | It is well recognized that following binding of ligand, many receptors undergo a process of agonist-induced receptor-mediated endocytosis (RME) or internalization. We recently characterized the intracellular pathway and kinetics of angiotensin II (AII)-RME in cultured explant-derived rat aortic vascular smooth muscle c... | ['Angiotensin II', 'Animals', 'Aorta, Thoracic', 'Binding, Competitive', 'Biphenyl Compounds', 'Endocytosis', 'Endosomes', 'Gold Colloid', 'Imidazoles', 'In Vitro Techniques', 'Losartan', 'Microscopy, Electron', 'Muscle, Smooth, Vascular', 'Organelles', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, Angiotensin', 'Tetrazo... | 7,903,871 | [['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['B01.050'], ['A07.015.114.056.372'], ['E05.196.080', 'G02.111.084', 'G02.111.570.120.309'], ['D02.455.426.559.389.185'], ['G04.417'], ['A11.284.430.214.190.875.190.880.337'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Toward establishing an empirical basis for the diagnosis of oppositional defiant disorder. | OBJECTIVES: (1) To determine the frequency of occurrence of oppositional defiant behaviors in the general population with a view to establishing empirical frequency cutoffs for the evaluation of oppositional defiant disorder (ODD). (2) To examine the effects of changes in the definition of ODD between DSM-III-R and DSM... | ['Female', 'Humans', 'Longitudinal Studies', 'Male', 'Mental Disorders', 'Prevalence', 'Psychiatric Status Rating Scales', 'Severity of Illness Index', 'Sex Factors'] | 8,824,064 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.372.500.750.500', 'N05.715.360.330.500.750.500', 'N06.850.520.450.500.750.500'], ['F03'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750'], ['F04.711.513.653'], ['E05.318.308.980.438.475.456.500',... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Penta-O-galloyl-â-D-glucose attenuates cisplatin-induced nephrotoxicity via reactive oxygen species reduction in renal epithelial cells and enhances antitumor activity in Caki-2 renal cancer cells. | Cisplatin shows limited therapeutic efficacy due to serious side effects such as nephrotoxicity and hepatotoxicity. In the present study, we demonstrate that 1,2,3,4,6-penta-O-galloyl-â-d-glucose (PGG) has protective effects against cisplatin-induced cytotoxicity and apoptosis in normal human primary renal epithelial c... | ['Antineoplastic Agents', 'Apoptosis', 'Cell Line, Tumor', 'Cell Survival', 'Cisplatin', 'Drug Therapy, Combination', 'Epithelial Cells', 'Humans', 'Hydrolyzable Tannins', 'Kidney', 'Protective Agents', 'Reactive Oxygen Species'] | 22,172,427 | [['D27.505.954.248'], ['G04.146.954.035'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['D01.210.375', 'D01.625.125', 'D01.710.100'], ['E02.319.310'], ['A11.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D02.241.223.100.300.200.299', 'D02.241.511.390.200.299', 'D02.455.426.559.389.127.281.200.299', ... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bacteriophage phi X174 DNA synthesis in Escherichia coli HF4704S (dnaHts) cells. | The DNA synthesis of bacteriophage phiX174 in Escherichia coli HF470S, a mutant temperature sensitive in the initiation of DNA replication (dnaHts), has been examined. In HF4704S cells, phiX174 can grow normally at 27 degree C whereas the phage cannot grow after the cessation of DNA synthesis of the host cells at 42 de... | ['Chloramphenicol', 'Coliphages', 'DNA Replication', 'DNA Viruses', 'DNA, Bacterial', 'DNA, Viral', 'Escherichia coli', 'Mutation', 'Temperature', 'Time Factors', 'Virus Replication'] | 1,096,950 | [['D02.033.455.706.300', 'D02.455.426.559.389.565.175', 'D02.640.529.175'], ['B04.123.205'], ['G02.111.225', 'G05.226'], ['B04.280'], ['D13.444.308.212'], ['D13.444.308.568'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.365.590'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The Relationship between Nutritional Status, Anemia and Other Vitamin Deficiencies in the Elderly Receiving Home Care. | AIM: The aim of this study was to evaluate the prevalence of anemia and other vitamin deficiencies among elderly home care patients and to evaluate the causes of anemia and effect of malnutrition as a contributing factor.METHODS: Anemia was defined according to the World Health Organization. Hemogram, serum iron, iron ... | ['Aged', 'Anemia', 'Anemia, Iron-Deficiency', 'Chronic Disease', 'Female', 'Ferritins', 'Folic Acid', 'Folic Acid Deficiency', 'Home Care Services', 'Homes for the Aged', 'Humans', 'Male', 'Malnutrition', 'Nutrition Assessment', 'Nutritional Status', 'Prevalence', 'Vitamin B 12', 'Vitamin B 12 Deficiency', 'Vitamin D D... | 31,367,734 | [['M01.060.116.100'], ['C15.378.071'], ['C15.378.071.196.300', 'C18.452.565.100'], ['C23.550.291.500'], ['D12.776.157.427.249', 'D12.776.556.579.249'], ['D03.633.100.733.631.400'], ['C18.654.521.500.133.699.308'], ['N02.421.143.524', 'N02.421.539.089'], ['J03.775.462', 'N02.278.825.462'], ['B01.050.150.900.649.313.988.... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Cross-sectional and longitudinal study protocols of the 'ADIposity and BOne metabolism: effects of eXercise-induced weight loss in obese adolescents' (ADIBOX) project. | INTRODUCTION: A need exists for sustainable and clinically effective weight management interventions, suitable for preventing well-linked chronic disease such as diabetes and cardiovascular disease and some less investigated secondary conditions such as bone alteration. The ADIposity and BOne metabolism: effects of eXe... | ['Adiposity', 'Adolescent', 'Australia', 'Body Composition', 'Bone Development', 'Cross-Sectional Studies', 'Female', 'Gene Expression Regulation, Developmental', 'Growth Plate', 'Humans', 'Longitudinal Studies', 'Male', 'Pediatric Obesity', 'Program Evaluation', 'Weight Loss', 'Weight Reduction Programs'] | 27,797,988 | [['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['M01.060.057'], ['Z01.639.100', 'Z01.678.100.373'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['G07.345.500.325.377.625.050.500', 'G11.427.578.050.500'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.4... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Geographicals [Z]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Actigraphic Analysis of Patients with Cervical Disc Herniation. | AIM: To analyze the relationship between the severity of pain and sleep disorder using wrist actigraphy in patients with cervical disc herniation (CDH).MATERIAL AND METHODS: Fifty patients with the diagnosis of CDH underwent subjective tests and actigraphic analysis in preoperative period, and at the end of postoperati... | ['Actigraphy', 'Adult', 'Cervical Vertebrae', 'Female', 'Humans', 'Intervertebral Disc Displacement', 'Male', 'Middle Aged', 'Sleep Wake Disorders'] | 27,560,526 | [['E01.370.520.049', 'E05.003.500'], ['M01.060.116'], ['A02.835.232.834.151'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.116.900.307', 'C23.300.707.952'], ['M01.060.116.630'], ['C10.886', 'C23.888.592.796', 'F03.870']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Hemocompatibility of polyacrylonitrile dialysis membrane immobilized with chitosan and heparin conjugate. | Chitosan (CS)/heparin (HEP) polyelectrolyte complex (PEC) was covalently immobilized onto the surface of polyacrylonitrile (PAN) membrane. The effect of surface modification on the protein adsorption and platelet adhesion, metabolites permeation and anticoagulation activity of the resulting membrane was investigated. S... | ['Adsorption', 'Animals', 'Anti-Bacterial Agents', 'Blood Proteins', 'Cells, Cultured', 'Chitin', 'Chitosan', 'Coated Materials, Biocompatible', 'Fibrinolytic Agents', 'Fibroblasts', 'Heparin', 'Humans', 'Macromolecular Substances', 'Materials Testing', 'Membranes, Artificial', 'Mice', 'Permeability', 'Pseudomonas aeru... | 14,738,859 | [['G01.030', 'G02.020'], ['B01.050'], ['D27.505.954.122.085'], ['D12.776.124'], ['A11.251'], ['D05.750.078.139', 'D09.698.211'], ['D05.750.078.139.500', 'D09.698.211.500'], ['D25.130.420', 'J01.637.051.130.420'], ['D27.505.519.421.750', 'D27.505.954.411.320', 'D27.505.954.502.427'], ['A11.329.228'], ['D09.698.373.400']... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Solar urticaria. Study of 20 cases]. | INTRODUCTION: Solar urticaria is an infrequent disorder, but is probably underdiagnosed. It is characterized by the sudden appearance of weals in areas that are not usually photoexposed after exposure to the sun or to artificial sources of visible or ultraviolet light. Few cases have been published in literature, so th... | ['Adult', 'Female', 'Humans', 'Male', 'Middle Aged', 'Sunlight', 'Urticaria'] | 16,476,328 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G01.358.500.505.650.836', 'G01.750.250.650.836', 'G01.750.770.578.836', 'G16.500.275.063.725.525', 'G16.500.750.775.525', 'N06.230.300.100.725.525'], ['C17.800.862.945', 'C20.543.480.904']] | ['Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Bioprinting of a functional vascularized mouse thyroid gland construct. | Bioprinting can be defined as additive biofabrication of three-dimensional (3D) tissues and organ constructs using tissue spheroids, capable of self-assembly, as building blocks. The thyroid gland, a relatively simple endocrine organ, is suitable for testing the proposed bioprinting technology. Here we report the biopr... | ['Animals', 'Bioprinting', 'Collagen', 'Computer Simulation', 'Endothelial Cells', 'Hydrogel, Polyethylene Glycol Dimethacrylate', 'Mice', 'Models, Theoretical', 'Neovascularization, Physiologic', 'Rats', 'Spheroids, Cellular', 'Thyroid Gland', 'Tissue Scaffolds'] | 28,707,625 | [['B01.050'], ['E05.111', 'J01.293.069.124'], ['D05.750.078.280', 'D12.776.860.300.250'], ['L01.224.160'], ['A11.436.275'], ['D02.033.455.250.700.485', 'D05.750.219.500', 'D05.750.741.485', 'D20.280.320.609.500', 'D25.720.532.500', 'D25.720.741.485', 'D26.255.165.320.375.375', 'J01.637.051.720.584.500', 'J01.637.051.72... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Gender differences in predictors of initiation, retention, and completion in an HMO-based substance abuse treatment program. | We studied gender differences in treatment process indicators among 293 HMO members recommended for substance abuse treatment. Treatment initiation, completion, and time spent in treatment did not differ by gender, but factors predicting these outcomes differed markedly. Initiation was predicted in women by alcohol dia... | ['Adult', 'Female', 'Gender Identity', 'Health Maintenance Organizations', 'Humans', 'Male', 'Patient Acceptance of Health Care', 'Patient Compliance', 'Patient Dropouts', 'Retention, Psychology', 'Sex Factors', 'Substance Abuse Treatment Centers', 'Substance-Related Disorders', 'United States'] | 12,495,790 | [['M01.060.116'], ['F01.393.446.250', 'F01.752.747.385.200', 'F01.752.747.722.200', 'F02.739.794.793.200'], ['N03.219.521.576.343.800.400', 'N03.219.521.576.343.925.400', 'N04.452.758.244.425', 'N04.590.374.410.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.100.150.750.500', 'F01.145.488.887.500', 'N05.3... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Effect of depression on the speed of recall of pleasant and unpleasant experiences. | An experiment is described in which depressed patients were asked to recall pleasant or unpleasant experiences from their past life in response to a standard series of stimulus words. The ratio between the time for recall of pleasant and unpleasant experiences was found to fall progressively with increasing severity o... | ['Adult', 'Association', 'Depression', 'Emotions', 'Extraversion, Psychological', 'Female', 'Happiness', 'Humans', 'Male', 'Memory', 'Mental Recall', 'Middle Aged', 'Neurotic Disorders', 'Personality Inventory', 'Time Factors'] | 1,161,955 | [['M01.060.116'], ['F02.463.425.069', 'F04.754.720.346'], ['F01.145.126.350'], ['F01.470'], ['F01.752.747.246', 'F02.739.794.253'], ['F01.470.516'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.425.540'], ['F02.463.425.540.641'], ['M01.060.116.630'], ['F03.080.550', 'F03.650'], ['F04.711.647.513'], ['G01.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Expression of tumor-associated glycoprotein 72 in prostatic intraepithelial neoplasia and prostatic adenocarcinoma. | Tumor-associated glycoprotein 72 is a high-molecular-weight sialomucin that is expressed selectively in various adenocarcinomas, including those of the prostate. We utilized the monoclonal antibodies B72.3 and CC49 to examine the expression of TAG-72 in high-grade prostatic intraepithelial neoplasia (PIN), localized ad... | ['Adenocarcinoma', 'Antibodies, Monoclonal', 'Antigens, Neoplasm', 'Carcinoma in Situ', 'Cell Membrane', 'Cytoplasm', 'Glycoproteins', 'Humans', 'Immunoenzyme Techniques', 'Male', 'Neoplasm Staging', 'Prostatectomy', 'Prostatic Neoplasms'] | 7,617,651 | [['C04.557.470.200.025'], ['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.285'], ['C04.557.470.200.240'], ['A11.284.149'], ['A11.284.430.214'], ['D09.400.430', 'D12.776.395'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.478.566.350', 'E05.478.583.400',... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bridging taxonomic and disciplinary divides in infectious disease. | Pathogens traverse disciplinary and taxonomic boundaries, yet infectious disease research occurs in many separate disciplines including plant pathology, veterinary and human medicine, and ecological and evolutionary sciences. These disciplines have different traditions, goals, and terminology, creating gaps in communic... | ['Animals', 'Communicable Disease Control', 'Communicable Diseases', 'Disease Outbreaks', 'Disease Vectors', 'Ecosystem', 'Health Policy', 'Humans', 'Interdisciplinary Communication', 'Plants'] | 22,086,388 | [['B01.050'], ['N06.850.780.200'], ['C01.221', 'C23.550.291.531'], ['N06.850.290'], ['N06.850.335.188', 'N06.850.520.203.375'], ['G16.500.275.157', 'N06.230.124'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205.249', 'L01.143... | ['Organisms [B]', 'Health Care [N]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 |
Immunohistochemical localization of neurocalcin in human sensory neurons and mechanoreceptors. | The localization of neurocalcin in the developing and adult human peripheral nervous system (dorsal root and sympathetic ganglia (DRG, SG), and enteric nervous system (ENS)) was investigated using immunohistochemistry. A subpopulation of large-sized neurons in DRG of 9 and 12 weeks old embryos showed immunoreactivity (... | ['Adult', 'Axons', 'Calcium-Binding Proteins', 'Embryo, Mammalian', 'Ganglia, Spinal', 'Humans', 'Immunohistochemistry', 'Male', 'Mechanoreceptors', 'Middle Aged', 'Motor Endplate', 'Motor Neurons', 'Muscle, Skeletal', 'Nerve Tissue Proteins', 'Neurocalcin', 'Neurons, Afferent', 'Proprioception', 'Receptors, Calcium-Se... | 10,674,628 | [['M01.060.116'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['D12.776.157.125'], ['A16.254'], ['A08.340.390.340', 'A08.800.350.340', 'A08.800.800.720.725.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', ... | ['Named Groups [M]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Molecular identification of three Ompok species using mitochondrial COI gene. | A DNA-based barcode identification system that is applicable to all animal species will provide a simple, universal tool for the identification of fish species. The barcode system is based on sequence diversity in subunit 1 cytochrome c oxidase (COI) gene. Identification and characterization of fish species based on mo... | ['Animals', 'Base Sequence', 'Catfishes', 'DNA Primers', 'DNA, Mitochondrial', 'Electron Transport Complex IV', 'India'] | 22,295,861 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.050.150.900.493.080'], ['D13.695.578.424.450.275', 'D27.720.470.530.600.223.600'], ['D13.444.308.283.225'], ['D05.500.562.374', 'D08.811.600.250.687', 'D08.811.682.285', 'D12.776.157.530.450.250.875.304', 'D12.776.543.277.687', 'D12.776.543.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 |
Iron response regulator protein IrrB in Magnetospirillum gryphiswaldense MSR-1 helps control the iron/oxygen balance, oxidative stress tolerance, and magnetosome formation. | Magnetotactic bacteria are capable of forming nanosized, membrane-enclosed magnetosomes under iron-rich and oxygen-limited conditions. The complete genomic sequence of Magnetospirillum gryphiswaldense strain MSR-1 has been analyzed and found to contain five fur homologue genes whose protein products are predicted to be... | ['Amino Acid Sequence', 'Down-Regulation', 'Ferrosoferric Oxide', 'Iron', 'Iron-Regulatory Proteins', 'Magnetosomes', 'Magnetospirillum', 'Oxidative Stress', 'Oxygen', 'Sequence Alignment', 'Sequence Deletion'] | 26,386,052 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['D01.490.100.375', 'D01.490.200.350', 'D01.578.285'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D12.776.494'], ['A11.284.430.214.190.875.450', 'A20.859'], ['B03.440.400.425.708.500', 'B03.660.050.755.750.... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Long-term effectiveness of antimalarial drugs in rheumatic diseases. | OBJECTIVE: The purpose of this study was to compare the long-term effectiveness between chloroquine (CQ) and hydroxychloroquine (HCQ).METHODS: Medical charts of all patients seen by eight rheumatologists practising in two tertiary care centres and starting antimalarial treatment between January 1985 and December 1993 w... | ['Adult', 'Antimalarials', 'Antirheumatic Agents', 'Arthritis', 'Arthritis, Rheumatoid', 'Chloroquine', 'Female', 'Follow-Up Studies', 'Humans', 'Hydroxychloroquine', 'Lupus Erythematosus, Systemic', 'Male', 'Middle Aged', 'Retrospective Studies', 'Rheumatic Diseases', 'Time Factors', 'Treatment Outcome'] | 9,893,568 | [['M01.060.116'], ['D27.505.954.122.250.100.085'], ['D27.505.954.329'], ['C05.550.114'], ['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['D03.633.100.810.050.180'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Eating behavior influences diet, weight, and central obesity in women after pregnancy. | OBJECTIVE: The aim of this study was to explore whether type of eating behavior is related to diet and overweight in women after childbirth.METHODS: In a prospective mother-infant study, women's (N = 189) eating behavior, dietary intake from food diaries, weight, and waist circumference (WC) were measured at 6, 12, 24,... | ['Adiposity', 'Adolescent', 'Adult', 'Body Mass Index', 'Body Weight', 'Diet Records', 'Energy Intake', 'Feeding Behavior', 'Female', 'Humans', 'Hyperphagia', 'Logistic Models', 'Obesity, Abdominal', 'Pregnancy', 'Prospective Studies', 'Reproducibility of Results', 'Surveys and Questionnaires', 'Waist Circumference', '... | 23,800,568 | [['E01.370.600.115.100.062.500', 'G02.111.130.134.500', 'G03.180.134.500', 'G07.100.049.134.500'], ['M01.060.057'], ['M01.060.116'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Serum progesterone at the time of surgery and survival in women with premenopausal operable breast cancer. | Serum progesterone and oestradiol levels have been measured in 210 premenopausal women with operable breast cancer on samples taken within 3 days of tumour excision. There was no relation between oestradiol level and time since last menstrual period, nor any effect of oestradiol value on prognosis. However, serum proge... | ['Breast Neoplasms', 'Estradiol', 'Female', 'Humans', 'Lymphatic Metastasis', 'Menstrual Cycle', 'Premenopause', 'Progesterone', 'Prognosis', 'Random Allocation', 'Retrospective Studies', 'Survival Analysis', 'Time Factors'] | 8,018,400 | [['C04.588.180', 'C17.800.090.500'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.550.727.650.560'], ['G08.686.605'], ['G08.686.157.500.812', 'G08.686.841.249.500.812'], ['D04.210.500.745.745.654.829', 'D06.472.334.734.623', 'D06.472.3... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Vagal and adrenal influences on gastric secretion in Shay rats. | The present experiment was planned to assess the role of vagus and adrenals in gastric secretion in the pylorus ligated rats. Vagotomy significantly reduced the volume of gastric juice but the reduction following adrenalectomy was not significant. Both vagotomy and adrenalectomy significantly reduced the free acid, tot... | ['Adrenal Glands', 'Adrenalectomy', 'Animals', 'Female', 'Gastric Juice', 'Male', 'Pepsin A', 'Rats', 'Vagotomy', 'Vagus Nerve'] | 326,663 | [['A06.300.071'], ['E04.270.115'], ['B01.050'], ['A12.200.307'], ['D08.811.277.656.074.500.700', 'D08.811.277.656.300.048.700'], ['B01.050.150.900.649.313.992.635.505.700'], ['E04.525.210.105.600.850'], ['A08.800.050.050.925', 'A08.800.050.600.825', 'A08.800.800.060.920', 'A08.800.800.120.900']] | ['Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Radiation hybrid mapping of the two highly homologous human-variant pMCHL genes by PCR-SSCP. | When gene loci are very similar in sequence, as in gene families or multiple pseudogenes, it is difficult to determine the specific location of the individual genes. We show here that applying PCR-SSCP to a radiation hybrid panel allowed mapping and specific sequencing of two genes with only a few sequence differences.... | ['Alleles', 'Animals', 'Chromosome Mapping', 'Chromosomes, Human, Pair 5', 'Cricetinae', 'Humans', 'Hybrid Cells', 'Hypothalamic Hormones', 'Molecular Sequence Data', 'Polymerase Chain Reaction', 'Polymorphism, Single-Stranded Conformational', 'Protein Precursors', 'Sequence Analysis, DNA', 'Sequence Homology, Nucleic ... | 9,685,321 | [['G05.360.340.024.340.030'], ['B01.050'], ['E05.393.183'], ['A11.284.187.520.300.280.290', 'G05.360.162.520.300.280.290'], ['B01.050.150.900.649.313.992.635.075.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.600'], ['D06.472.699.327', 'D12.644.400.400', 'D12.644.548.365', 'D12.776.631.650.405'], ['L... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Prevalence of female genital tuberculosis, its risk factors and associated clinical features among the women of Andaman Islands, India: a community-based study. | OBJECTIVE: There is scarcity of information on the prevalence of female genital tuberculosis (FGTB) in the community. The present study was carried out to estimate the prevalence of FGTB, its risk factors and associated clinical features.STUDY DESIGN: Community-based cross-sectional survey.METHODS: This study was carri... | ['Adult', 'Cross-Sectional Studies', 'Female', 'Humans', 'India', 'Infertility, Female', 'Middle Aged', 'Oligomenorrhea', 'Prevalence', 'Risk Factors', 'Tuberculosis, Female Genital', 'Young Adult'] | 28,404,534 | [['M01.060.116'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.393'], ['C13.351.500.365.700'], ['M01.060.116.630'], ['C23.550.568.937'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
A comparison of a theophylline-ephedrine combination with terbutaline. | In a single-blind, crossover study 10 adult asthmatic patients received a theophylline-ephedrine combination tablet (theophylline 90 mg, ephedrine 16 mg and phenobarbital 25 mg in an immediate release layer and theophylline 90 mg and ephedrine 32 mg in a sustained release layer) twice daily or terbutaline 5 mg three ti... | ['Adult', 'Asthma', 'Clinical Trials as Topic', 'Cyclic AMP', 'Drug Combinations', 'Ephedrine', 'Humans', 'Lung', 'Terbutaline', 'Theophylline', 'Tremor'] | 208,429 | [['M01.060.116'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D26.310'], ['D02.033.100.624.302', 'D02.033.755.6... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Rare complication of calculosis of the gallbladder: Bouveret's syndrome]. | The authors report a case, they had the opportunity to observe, of pyloric stenosis, secondary to the migration of two big gall-stones into stomach through a cholecysto-gastric fistula. As the event is extremely rare, they discuss some clinical, diagnostical and therapeutical aspects of same. | ['Aged', 'Cholelithiasis', 'Female', 'Humans', 'Pyloric Stenosis', 'Syndrome', 'Tachycardia, Paroxysmal'] | 6,545,139 | [['M01.060.116.100'], ['C06.130.409'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C06.405.748.340.690'], ['C23.550.288.500'], ['C14.280.067.845.695', 'C14.280.123.875.695', 'C23.550.073.845.695']] | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Targeted construction of temperature-sensitive mutations in vaccinia virus by replacing clustered charged residues with alanine. | The feasibility of using "clustered charge-to-alanine" mutagenesis (replacement by alanine of two or more charged residues clustered in a five- or six-amino acid sequence) to create temperature-sensitive, conditionally lethal mutations in vaccinia virus was examined by creating nine mutations in the vaccinia virus gene... | ['Alanine', 'Amino Acid Sequence', 'Animals', 'Cell Line', 'Genes, Dominant', 'Genes, Viral', 'Isatin', 'Kinetics', 'Molecular Sequence Data', 'Mutagenesis', 'Mutation', 'Phenotype', 'Temperature', 'Time Factors', 'Vaccinia virus', 'Viral Plaque Assay', 'Viral Proteins'] | 8,183,946 | [['D12.125.042'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A11.251.210'], ['G05.360.340.024.340.240', 'G05.420.320'], ['G05.360.340.024.340.364.875', 'G05.360.340.358.024.875', 'G05.360.340.358.840.500'], ['D03.633.100.473.525'], ['G01.374.661', 'G02.111.490'], ['L01.453.245.667'], ['G05.558'], ['G05.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Design, synthesis, antibacterial activity, and molecular docking studies of novel hybrid 1,3-thiazine-1,3,5-triazine derivatives as potential bacterial translation inhibitor. | Some novel hybrid 1,3-thiazine-1,3,5-triazine derivatives were synthesized and tested for antibacterial activity. Compounds 8c and 8f were found active against Gram positive and Gram negative microorganisms. Molecular docking studies have been performed on eubacterial ribosomal decoding A site (Escherichia coli 16S rRN... | ['Anti-Bacterial Agents', 'Bacteria', 'Bacterial Infections', 'Humans', 'Molecular Docking Simulation', 'Protein Biosynthesis', 'Thiazines', 'Triazines'] | 22,702,334 | [['D27.505.954.122.085'], ['B03'], ['C01.150.252'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.595.249', 'L01.224.160.249'], ['G02.111.660.871', 'G03.734.871', 'G05.297.670'], ['D02.886.665', 'D03.383.855'], ['D03.383.931']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Cost benefit analysis of neurostimulation for chronic pain. | OBJECTIVES: To assess the healthcare utilization of patients with intractable chronic neuropathic pain treated with spinal cord stimulation and peripheral nerve stimulation and to provide a cost-benefit analysis.METHODS: The case records of 222 consecutive patients who received spinal cord stimulation or peripheral ner... | ['Adult', 'Aged', 'Chronic Disease', 'Cost-Benefit Analysis', 'Delivery of Health Care', 'Demography', 'Electric Stimulation Therapy', 'Female', 'Humans', 'Insurance, Health, Reimbursement', 'Male', 'Middle Aged', 'Pain', 'Pain Management', 'Retrospective Studies', 'Surveys and Questionnaires', 'Treatment Outcome'] | 15,502,691 | [['M01.060.116'], ['M01.060.116.100'], ['C23.550.291.500'], ['N03.219.151.125'], ['N04.590.374', 'N05.300'], ['I01.240', 'N01.224', 'N06.850.505.400'], ['E02.331', 'E02.779.468', 'E02.831.535.468'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.521.576.343.480', 'N03.219.521.710'], ['M01.060.116.630'], ['C... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Enhanced chemotherapy of cancer using pH-sensitive mesoporous silica nanoparticles to antagonize P-glycoprotein-mediated drug resistance. | Multidrug resistance (MDR) is the major clinical obstacle in the management of cancer by chemotherapy. Overexpression of ATP-dependent efflux transporter P-glycoprotein (PGP) is a key factor contributing to multidrug resistance of cancer cells. The purpose of the present study was to use the endosomal pH-sensitive MSN ... | ['ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Animals', 'Antineoplastic Agents', 'Apoptosis', 'Cell Line, Tumor', 'Cell Survival', 'Doxorubicin', 'Drug Resistance, Neoplasm', 'Endocytosis', 'Humans', 'Hydrazones', 'Hydrogen-Ion Concentration', 'Male', 'Mice', 'Mice, Nude', 'Nanoparticles', 'Neoplasms', '... | 21,411,714 | [['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.153', 'D12.776.543.585.100.200.125', 'D12.776.543.585.450.074.500.500.250.125'], ['B01.050'], ['D27.505.954.248'], ['G04.146.954.035'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'],... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Influence of postnatal overnutrition and pregnancy on non-insulin dependent diabetes induced in Wistar rats by neonatal streptozotocin. | Wistar rats with non-insulin dependent diabetes induced by neonatal streptozotocin (STZ) administration were raised either in large or in small litters. The STZ-treated rats from small litters showed a higher body weight as well as increased blood glucose levels compared with vehicle- and STZ-treated rats reared in lar... | ['Animal Nutritional Physiological Phenomena', 'Animals', 'Animals, Newborn', 'Blood Glucose', 'Body Weight', 'Diabetes Mellitus, Experimental', 'Diabetes Mellitus, Type 2', 'Female', 'Homeostasis', 'Pregnancy', 'Pregnancy in Diabetics', 'Rats', 'Rats, Wistar', 'Streptozocin'] | 8,867,903 | [['G07.203.650.161'], ['B01.050'], ['B01.050.050.282'], ['D09.947.875.359.448.500'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['C18.452.394.750.149', 'C19.246.300'], ['G07.410'], ['G08.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Percutaneous phenol block of the upper thoracic sympathetic chain with computed tomography guidance. A new technique. | Twenty-one percutaneous neurolyses of the upper thoracic sympathetic chain were performed in 12 patients with CT guidance by a single injection of 1 to 3 ml of phenol at the level of Th3. Results were assessed after a follow-up period varying from 4 to 33 months. Three patients with hyperhidrosis had immediate and comp... | ['Adult', 'Cervical Rib Syndrome', 'Female', 'Ganglia, Sympathetic', 'Humans', 'Hyperhidrosis', 'Male', 'Middle Aged', 'Phenol', 'Phenols', 'Punctures', 'Radiography, Thoracic', 'Raynaud Disease', 'Sympathectomy, Chemical', 'Tomography, X-Ray Computed'] | 2,960,340 | [['M01.060.116'], ['C10.668.829.550.850.200', 'C14.907.863.200', 'C16.131.621.174'], ['A08.340.315.350', 'A08.800.050.300.300', 'A08.800.050.800.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.800.946.350'], ['M01.060.116.630'], ['D02.455.426.559.389.657.595'], ['D02.455.426.559.389.657'], ['E02.800', 'E0... | ['Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Expression of STK15 gene and chromosomal instability in laryngeal carcinoma]. | To assess the relationship between expression of STK15 gene and chromosomal instability in laryngeal squamous cell carcinoma, RNA was extracted from 50 cases of laryngeal squamous cell carcinoma and paired normal tissue and Hep-2 cell line. cDNA was synthesized through reverse transcription, which was amplified by PCR ... | ['Aurora Kinase A', 'Aurora Kinases', 'Carcinoma, Squamous Cell', 'Chromosome Aberrations', 'Gene Expression Regulation, Enzymologic', 'Gene Expression Regulation, Neoplastic', 'Humans', 'Karyotyping', 'Laryngeal Neoplasms', 'Protein-Serine-Threonine Kinases', 'RNA, Neoplasm', 'Reverse Transcriptase Polymerase Chain Re... | 12,693,093 | [['D08.811.913.696.620.682.700.103.500', 'D12.776.167.049.500'], ['D08.811.913.696.620.682.700.103', 'D12.776.167.049'], ['C04.557.470.200.400', 'C04.557.470.700.400'], ['C23.550.210', 'G05.365.590.175'], ['G05.308.320'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.385.315', 'E05... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Palatal lift prosthesis for bolus transport in a patient with dysphagia: A clinical report. | A palatal lift prosthesis (PLP) is an intraoral device that provides lift for the soft palate. The usual purpose of a PLP is to reduce nasopharyngeal reflux and the hypernasal speech caused by velopharyngeal incompetence. However, for this patient, the main purpose was to relieve a functional blockage at the oropharyng... | ['Adult', 'Deglutition Disorders', 'Food', 'Humans', 'Male', 'Palate, Soft', 'Prostheses and Implants'] | 28,159,343 | [['M01.060.116'], ['C06.405.117.119', 'C09.775.174'], ['G07.203.300', 'J02.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A14.549.617.780'], ['E07.695']] | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 |
Expression of endothelial and inducible NOS-isoforms is increased in Alzheimer's disease, in APP23 transgenic mice and after experimental brain lesion in rat: evidence for an induction by amyloid pathology. | The nitric oxide-synthesizing enzyme nitric oxide synthase (NOS) is present in the mammalian brain in three different isoforms, two constitutive enzymes (i.e., neuronal, nNOS, and endothelial eNOS) and one inducible enzyme (iNOS). All three isoforms are aberrantly expressed in Alzheimer's disease giving rise to elevate... | ['Aged', 'Aged, 80 and over', 'Alzheimer Disease', 'Amyloid beta-Protein Precursor', 'Animals', 'Antibody Specificity', 'Astrocytes', 'Brain', 'Brain Injuries', 'Cell Count', 'Cerebral Cortex', 'Female', 'Gene Expression Regulation, Enzymologic', 'Gliosis', 'Humans', 'Immunohistochemistry', 'Male', 'Mice', 'Mice, Trans... | 11,532,247 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C10.228.140.380.100', 'C10.574.945.249', 'F03.615.400.100'], ['D12.776.049.407.249', 'D12.776.543.039', 'D12.776.645.468.500', 'D12.776.811.050'], ['B01.050'], ['G12.100'], ['A08.637.200', 'A11.650.200'], ['A08.186.211'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.3... | ['Named Groups [M]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Central cardiovascular action of neuropeptide Y in conscious rabbits. | We determined the central interactions of neuropeptide Y and leptin on cardiovascular and sympathetic responses in conscious rabbits. Intracerebroventricular injections of neuropeptide Y (0.1 and 1 nmol/40 microL) elicited dose-related decreases in arterial pressure and renal sympathetic nerve activity without a signif... | ['Anesthesia', 'Animals', 'Baroreflex', 'Cardiovascular System', 'Central Nervous System', 'Injections, Intraventricular', 'Leptin', 'Male', 'Neuropeptide Y', 'Pressoreceptors', 'Rabbits', 'Sympathetic Nervous System'] | 11,116,122 | [['E03.155'], ['B01.050'], ['G09.330.380.057', 'G11.561.731.063'], ['A07'], ['A08.186'], ['E02.319.267.530.550'], ['D06.472.699.042.500', 'D12.644.276.024.500', 'D12.644.548.011.500', 'D12.776.467.024.500', 'D23.529.024.500'], ['D12.644.400.500', 'D12.776.631.650.500'], ['A08.675.650.915.750.750', 'A08.800.050.800.900.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[The inheritance of the traits of resistance to fungal diseases by distant hybrids of wheat with amphiploids]. | The inheritance of resistance to powdery mildew, leaf rust and septorios of hybrids from crosses of wheat--rye and two wheat--Elymus amphiploids with durum and bread wheat was studied. Spontaneous hybridization was revealed to be a determining factor of the new available trait formation in the wide crosses. Control of ... | ['Crosses, Genetic', 'Hybridization, Genetic', 'Immunity, Innate', 'Mycoses', 'Plant Diseases', 'Polyploidy', 'Secale', 'Triticum'] | 10,857,202 | [['E05.393.281'], ['E05.820.150.390', 'G05.090.390'], ['G12.450.564'], ['C01.150.703'], ['G15.610'], ['C23.550.210.702', 'G05.365.590.175.677', 'G05.700.740'], ['B01.650.940.800.575.912.250.822.857'], ['B01.650.940.800.575.912.250.822.918']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Purification and properties of beta-alanine synthase from calf liver. | beta-Alanine synthase (EC 3.5.1.6) catalyzes the conversion of N-carbamyl-beta-alanine to beta-alanine, ammonia and CO2. The enzyme has been purified to apparent homogeneity from calf liver. The molecular size, pH optimum and substrate specificity have been determined. Sequence alignment of beta-alanine synthases with ... | ['Amidohydrolases', 'Animals', 'Cattle', 'Liver', 'Rats'] | 15,638,804 | [['D08.811.277.087'], ['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A03.620'], ['B01.050.150.900.649.313.992.635.505.700']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A general equation for the ratio of the areas below the blood or plasma concentration time-curves following intravenous and oral drug administration and its application to inter-subject variations in drug elimination. | 1 When a drug is metabolized in the liver the total area under the plasma or blood concentration-time curve following oral drug administration is less than the area obtained after intravenous drug administration. This difference has been termed the 'first-pass effect'. 2 General equations for the areas below the blood ... | ['Administration, Oral', 'Biopharmaceutics', 'Injections, Intravenous', 'Kidney', 'Liver', 'Mathematics', 'Models, Biological', 'Pharmaceutical Preparations'] | 1,234,504 | [['E02.319.267.100'], ['H01.158.703.003', 'H02.628.049'], ['E02.319.267.082.750', 'E02.319.267.530.540'], ['A05.810.453'], ['A03.620'], ['H01.548'], ['E05.599.395'], ['D26']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Effects of nasal instillation of a nitric oxide-releasing solution or parenteral administration of tilmicosin on the nasopharyngeal microbiota of beef feedlot cattle at high-risk of developing respiratory tract disease. | Nitric oxide has bactericidal and virucidal properties. Nasal instillation of a nitric oxide releasing solution (NORS) on arrival at the feedlot was recently reported as inferior to a parenteral injection of tilmicosin (macrolide antibiotic) for control of bovine respiratory disease (BRD) in cattle at high-risk of deve... | ['Animals', 'Anti-Bacterial Agents', 'Bovine Respiratory Disease Complex', 'Cattle', 'Female', 'Microbiota', 'Nasopharynx', 'Nitric Oxide', 'RNA, Bacterial', 'RNA, Ribosomal, 16S', 'Risk Factors', 'Tylosin'] | 28,231,472 | [['B01.050'], ['D27.505.954.122.085'], ['C01.748.085', 'C08.730.085', 'C22.196.090'], ['B01.050.150.900.649.313.500.380.271'], ['G06.591', 'G16.500.275.157.049.100.500', 'N06.230.124.049.100.500'], ['A04.623.557', 'A14.724.557'], ['D01.339.387', 'D01.625.550.500', 'D01.625.700.500', 'D01.650.550.587.600'], ['D13.444.73... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
[Suppressive effects of non-preferable plant alcohol extracts on diamondback moth Plutella xylostella population]. | In this paper, a life table and an interference index of population control (IIPC) were used to evaluate the effects of spraying the alcohol extracts of non-preferable plants on the dynamics of diamondback moth Plutella xylostella) population. The results showed that the alcohol extracts of Eupatorium odoratum, Lantana... | ['Animals', 'Chromolaena', 'Insect Control', 'Insecticides', 'Lantana', 'Moths', 'Plant Extracts', 'Population Control', 'Wedelia'] | 15,852,929 | [['B01.050'], ['B01.650.940.800.575.912.250.100.203'], ['N06.850.780.200.650.425'], ['D27.720.031.700.491', 'D27.888.723.491'], ['B01.650.940.800.575.912.250.583.990.411'], ['B01.050.500.131.617.720.500.500.937.650'], ['D20.215.784.500', 'D26.667'], ['I01.240.600.650', 'N01.224.625.650', 'N06.850.505.400.700.650'], ['B... | ['Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Making a difference: the construction of ethnicity in HIV and STI epidemiological research by the Dutch National Institute for Public Health and the Environment. | Biomedical and public health researchers and practitioners routinely record and comment on ethnicity: however, the use of this category is often vague and without explicit statement on what ethnicity is or how it correlates to health disparities. Presented here is an inquiry into the case of ethnicity in HIV/STI resear... | ['Biomedical Research', 'Epidemiologic Studies', 'Ethnic Groups', 'Female', 'HIV Infections', 'Health Status Disparities', 'Humans', 'Male', 'Netherlands', 'Public Health Administration', 'Research Design', 'Risk-Taking', 'Sexual Behavior', 'Sexually Transmitted Diseases'] | 21,601,970 | [['H01.770.644.145'], ['E05.318.372.500', 'N05.715.360.330.500', 'N06.850.520.450.500'], ['M01.686.754', 'N01.224.317'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['I01.240.425.675', 'N01.224.425.437', 'N06.850.505.400.425.675'], ['B01.05... | ['Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 1 |
[A case of internal ophthalmomyiasis in Kenya (author's transl)]. | An unusual case of ophthalmomyiasis is reported, in which two living fly larvae were observed inside the patient's eye. One larva was removed from the anterior chamber by paracentesis; the other was destroyed on the retina by photocoagulation. The mode of infestation, clinical picture and treatment are discussed in bri... | ['Adult', 'Anterior Chamber', 'Eye Diseases', 'Humans', 'Kenya', 'Male', 'Myiasis', 'Retina'] | 7,339,161 | [['M01.060.116'], ['A09.371.060.067'], ['C11'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.058.290.120.400'], ['C01.610.858.211.503'], ['A09.371.729']] | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Investigation by electron paramagnetic resonance spectroscopy of the molybdenum centre of respiratory nitrate reductase from Paracoccus denitrificans. | The molybdenum centre of respiratory nitrate reductase from Paracoccus denitrificans has been investigated by e.p.r. spectroscopy of Mo(V). In common with the centres of the analogous enzymes from Escherichia coli and Pseudomonas aeruginosa, it undergoes a pH- and anion-dependent transition between two different e.p.r.... | ['Electron Spin Resonance Spectroscopy', 'Molybdenum', 'Nitrate Reductase', 'Nitrate Reductases', 'Paracoccus denitrificans'] | 2,844,161 | [['E05.196.867.519.274'], ['D01.268.556.555', 'D01.268.956.500', 'D01.552.544.555'], ['D08.811.682.655.500.124'], ['D08.811.682.655.500'], ['B03.440.400.425.600.380', 'B03.660.050.750.600.125']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Head and Body Orientation Estimation Using Convolutional Random Projection Forests. | In this paper, we consider the problem of estimating the head pose and body orientation of a person from a low-resolution image. Under this setting, it is difficult to reliably extract facial features or detect body parts. We propose a convolutional random projection forest (CRPforest) algorithm for these tasks. A conv... | ['Algorithms', 'Head', 'Humans', 'Image Processing, Computer-Assisted', 'Models, Statistical', 'Neural Networks, Computer', 'Posture', 'Torso'] | 29,990,037 | [['G17.035', 'L01.224.050'], ['A01.456'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['G17.485', 'L01.224.050.375.605'], ['G11.427.695'], ['A01.923']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
A history of treatments for myasthenia gravis. | Much of the improvement in the treatment of myasthenia gravis (MG) over the past 125 years can be attributed to the effectiveness of general medical measures such as advances in respiratory care and the discovery of antibiotics. Although MG became the model of an antibody-mediated autoimmune disease in the 1970s (the m... | ['Cholinesterase Inhibitors', 'History, 19th Century', 'History, 20th Century', 'Humans', 'Immunosuppressive Agents', 'Myasthenia Gravis', 'Neurology', 'Thymectomy'] | 15,229,787 | [['D27.505.519.389.275', 'D27.505.519.625.120.300', 'D27.505.696.577.120.300'], ['K01.400.504.937'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.505.696.477.656'], ['C04.588.614.550.500', 'C04.730.856.490', 'C10.114.656', 'C10.574.781.588', 'C10.668.758.725', 'C20.111.258.500'], ['H02.40... | ['Chemicals and Drugs [D]', 'Humanities [K]', 'Organisms [B]', 'Diseases [C]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A randomized, double-blind, placebo-controlled, phase 1/2a study of the safety and immunogenicity of a live, attenuated human parainfluenza virus type 3 vaccine in healthy infants. | OBJECTIVE: To evaluate the safety, tolerability, immunogenicity, and viral shedding profiles of a recombinant, live, attenuated human parainfluenza virus type 3 (HPIV3) vaccine, rHPIV3cp45, in healthy HPIV3-seronegative infants 6 to <12 months of age.METHODS: In this double-blind, multicenter study, subjects were rando... | ['Antibodies, Viral', 'Double-Blind Method', 'Female', 'Genotype', 'Humans', 'Immune Tolerance', 'Infant', 'Male', 'Parainfluenza Vaccines', 'Parainfluenza Virus 3, Human', 'Phenotype', 'Placebos', 'Vaccines, Attenuated', 'Virus Shedding'] | 21,782,874 | [['D12.776.124.486.485.114.254', 'D12.776.124.790.651.114.254', 'D12.776.377.715.548.114.254'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['G05.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.535.425'], ['M01.060.703'], ['D20.215.894.899.500'], ['B04.820.480.937... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Determination of 7-aminoflunitrazepam, the major metabolite of flunitrazepam in urine by high performance thin-layer chromatography]. | A rapid and highly sensitive method, based on high performance thin-layer chromatography, is described for the qualitative and semiquantitative determination of 7-aminoflunitrazepam, the main metabolite of flunitrazepam in human urine. 7-Aminoflunitrazepam in specimen was extracted by solid phase extraction using GDX-4... | ['Chromatography, Thin Layer', 'Flunitrazepam', 'Fluorescamine', 'Humans', 'Indicators and Reagents'] | 12,541,981 | [['E05.196.181.400.537'], ['D03.633.100.079.080.070.320'], ['D02.455.426.779.345', 'D03.633.100.127.218', 'D04.711.345'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.470.410']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Novel adipokinetic hormones in the kissing bugs Rhodnius prolixus, Triatoma infestans, Dipetalogaster maxima and Panstrongylus megistus. | Peptides of the adipokinetic hormone (AKH)/red pigment-concentrating hormone (RPCH) family were isolated and sequenced from the retrocerebral corpora cardiaca of four kissing bugs which are all vectors of the protozoan Trypanosoma cruzi responsible for Chagas' disease. The sequence of three novel AKHs were deduced from... | ['Amino Acid Sequence', 'Animals', 'Female', 'Grasshoppers', 'Hemolymph', 'Insect Hormones', 'Lipid Metabolism', 'Male', 'Oligopeptides', 'Panstrongylus', 'Pyrrolidonecarboxylic Acid', 'Rhodnius', 'Sequence Analysis, Protein', 'Triatoma'] | 23,137,850 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.500.131.617.678.369'], ['A13.453'], ['D06.472.445.573'], ['G03.458'], ['D12.644.456'], ['B01.050.500.131.617.412.420.700.850.600'], ['D03.383.773.812.718', 'D12.125.067.625.850', 'D12.125.072.401.761'], ['B01.050.500.131.617.412.420.700.850.700'], ['E0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effect of light and reductones on differentiation of Pleurotus ostreatus. | Vegetative mycelia of Pleurotus ostreatus were differentiated into primordia and subsequently into fruit bodies in synthetic sucrose-asparagine medium when exposed to light at low temperature. During photo-morphogenesis, L-ascorbic acid-like substances called reductones were produced. L-ascorbic acid, D-erythroascorbic... | ['Antioxidants', 'Ascorbic Acid', 'Culture Media', 'Light', 'Pleurotus', 'Temperature'] | 21,369,982 | [['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['D02.241.081.844.107', 'D02.241.511.902.107', 'D09.811.100'], ['D27.720.470.305', 'E07.206'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['B01.300.179.100.650'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.77... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Food intake, dietary supplements and survival time of scorbutic guinea pigs. | Manual presentation of a liquid scorbutogenic diet permitted a more complete characterisation of the terminal stages of scurvy in guinea pigs. A bioflavonoid preparation from orange peel, previously shown both to increase the tissue concentrations of ascorbic acid and to stimulate the growth of hypovitaminotic C guinea... | ['Animals', 'Diet', 'Flavonoids', 'Guinea Pigs', 'Male', 'Scurvy', 'Tetrahydrofolates'] | 958,649 | [['B01.050'], ['G07.203.650.240'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['B01.050.150.900.649.313.992.550'], ['C14.907.454.800', 'C15.378.463.515.800', 'C18.654.521.500.133.115.661'], ['D03.633.100.733.631.400.800', 'D08.211.840']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Diffusion-weighted MR imaging in monitoring the effect of a vascular targeting agent on rhabdomyosarcoma in rats. | PURPOSE: To evaluate diffusion-weighted magnetic resonance (MR) imaging for monitoring tumor response in rats after administration of combretastatin A4 phosphate.MATERIALS AND METHODS: Study protocol was approved by local ethical committee for animal care and use. Rhabdomyosarcomas implanted subcutaneously in both flan... | ['Animals', 'Antineoplastic Agents, Phytogenic', 'Bibenzyls', 'Contrast Media', 'Diffusion Magnetic Resonance Imaging', 'Gadolinium DTPA', 'Image Processing, Computer-Assisted', 'Injections, Intraperitoneal', 'Male', 'Rats', 'Rhabdomyosarcoma', 'Stilbenes'] | 15,734,932 | [['B01.050'], ['D27.505.954.248.179'], ['D02.455.426.559.389.140.308'], ['D27.505.259.500', 'D27.720.259'], ['E01.370.350.825.500.150'], ['D02.092.782.590.401', 'D02.241.081.018.639.400', 'D02.257.141'], ['L01.224.308'], ['E02.319.267.530.490'], ['B01.050.150.900.649.313.992.635.505.700'], ['C04.557.450.590.550.660', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
The importance of transdisciplinary collaborations for understanding and resolving health disparities. | Group disparities in health have been documented for several decades. Despite recent efforts to eliminate them, group differences persist and challenge the ability of scientists to address them using traditional research paradigms. Because the determinants of disparities occur at multiple levels, from the molecular to ... | ['Community-Institutional Relations', 'Cooperative Behavior', 'Group Processes', 'Health Services Research', 'Health Status Disparities', 'Humans', 'Interdisciplinary Communication', 'Interinstitutional Relations', 'Interprofessional Relations'] | 20,446,184 | [['N04.452.822.210'], ['F01.145.813.115'], ['F01.829.316'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['I01.240.425.675', 'N01.224.425.437', 'N06.850.505.400.425.675'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.401.205.249', 'L01.143.865.500'], ['N04.452.822.400'], ['F01.829.401.205']] | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 |
Discovery of potent 1H-imidazo[4,5-b]pyridine-based c-Met kinase inhibitors via mechanism-directed structural optimization. | Starting from our previously identified novel c-Met kinase inhibitors bearing 1H-imidazo[4,5-h][1,6]naphthyridin-2(3H)-one scaffold, a global structural exploration was conducted to furnish an optimal binding motif for further development, directed by the enzyme inhibitory mechanism. First round SAR study picked two im... | ['Binding Sites', 'Cell Line, Tumor', 'Drug Evaluation, Preclinical', 'Humans', 'Imidazoles', 'Molecular Dynamics Simulation', 'Protein Binding', 'Protein Kinase Inhibitors', 'Protein Structure, Tertiary', 'Protein-Tyrosine Kinases', 'Proto-Oncogene Proteins c-met', 'Pyridines', 'Structure-Activity Relationship'] | 25,529,740 | [['G02.111.570.120'], ['A11.251.210.190', 'A11.251.860.180'], ['E05.290.750', 'E05.337.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.383.129.308'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['G02.111.679', 'G03.808'], ['D27.505.519.389.755'], ['G02.111.570.820.709.610'], ['D08.811.913.6... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Endoscopic versus transaxillary thoracic sympathectomy for primary axillary and palmar hyperhidrosis and/or facial blushing: 5-year-experience. | Thoracic sympathectomy is effective in the permanent cure of primary axillary and palmar hyperhidrosis and facial blushing, which can be so troublesome for patients that their social and professional relations can be affected. Between October 1988 and April 1994, a total of 50 thoracic sympathectomies (10 surgical and ... | ['Adult', 'Blushing', 'Endoscopy', 'Female', 'Humans', 'Hyperhidrosis', 'Male', 'Retrospective Studies', 'Sympathectomy', 'Treatment Outcome'] | 8,664,016 | [['M01.060.116'], ['F01.145.209.530.136', 'F02.830.158'], ['E01.370.388.250', 'E04.502.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.800.946.350'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N05.715.360.330.500.500.500', 'N05.715.360.330.500.750.825', 'N06.850.520.450.500.500.500', 'N06.850... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Evaluation of diagnostic yield and clinical impact of capsule endoscopy in patients with obscure gastrointestinal bleeding]. | BACKGROUND AND AIMS: The major indication of small bowel capsule endoscopy is the diagnostics of obscure gastrointestinal bleeding. The present retrospective study was aimed to analyze the diagnostic yield, positive and negative predictive values and clinical impact of capsule endoscopy in patients with obscure gastroi... | ['Angiodysplasia', 'Constriction, Pathologic', 'Crohn Disease', 'Diagnosis, Differential', 'Endoscopes, Gastrointestinal', 'Endoscopy, Gastrointestinal', 'Female', 'Gastrointestinal Hemorrhage', 'Helminthiasis', 'Humans', 'Inflammation', 'Intestinal Diseases', 'Intestinal Neoplasms', 'Intestine, Small', 'Male', 'Middle... | 17,066,599 | [['C14.907.075'], ['C23.300.287'], ['C06.405.205.731.500', 'C06.405.469.432.500'], ['E01.171'], ['E07.230.220.260', 'E07.858.240.260'], ['E01.370.372.250.250', 'E01.370.388.250.250.250', 'E04.210.240.250', 'E04.502.250.250.250'], ['C06.405.227', 'C23.550.414.788'], ['C01.610.335'], ['B01.050.150.900.649.313.988.400.112... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Named Groups [M]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 0 |
Solution stability of the monoclonal antibody-vinca alkaloid conjugate, KS1/4-DAVLB. | A 3-month solution stability study at 5 degrees C of the monoclonal antibody-vinca alkaloid conjugate KS1/4-DAVLB indicated that phosphate-buffered saline solutions at pH 4.5-5.5 had little tendency to lose vinca by hydrolysis, improved vinca stability, showed acceptable physical stability, and formed minimal amounts o... | ['Antibodies, Monoclonal', 'Chromatography, High Pressure Liquid', 'Drug Stability', 'Enzyme-Linked Immunosorbent Assay', 'Hydrogen-Ion Concentration', 'Hydrolysis', 'Immunoglobulin G', 'Proteins', 'Solutions', 'Spectrophotometry, Ultraviolet', 'Vinca Alkaloids'] | 1,796,044 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['E05.196.181.400.300'], ['E05.916.330'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['G02.300'], ['G02.380'], ['D12.776.124.486.485.114.619.393', 'D1... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Internet use among adolescent and young adults (AYA) with cancer. | BACKGROUND: The Internet serves as an important resource for adult cancer patients, but little is known about Internet use among adolescent and young adults (AYA) with cancer. The aims of this study were to describe (1) cancer-specific websites which AYA with cancer visit and (2) Internet features desired by AYA on can... | ['Adolescent', 'Adult', 'Data Collection', 'Female', 'Humans', 'Information Services', 'Internet', 'Male', 'Neoplasms', 'North America', 'Patient Education as Topic'] | 18,506,753 | [['M01.060.057'], ['M01.060.116'], ['E05.318.308', 'L01.399.250', 'N05.715.360.300', 'N06.850.520.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453'], ['L01.224.230.110.500'], ['C04'], ['Z01.107.567'], ['I02.233.332.500', 'N02.421.726.407.680']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 1 |
The specificity of perceptual learning in speech processing. | We conducted four experiments to investigate the specificity of perceptual adjustments made to unusual speech sounds. Dutch listeners heard a female talker produce an ambiguous fricative [?] (between [f] and [s]) in [f]- or [s]-biased lexical contexts. Listeners with [f]-biased exposure (e.g., [witlo?]; from witlof, "c... | ['Cognition', 'Discrimination Learning', 'Humans', 'Language', 'Phonetics', 'Psycholinguistics', 'Speech Discrimination Tests', 'Speech Perception', 'Surveys and Questionnaires', 'Visual Perception'] | 15,971,687 | [['F02.463.188'], ['F02.463.425.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.145.209.399', 'L01.559'], ['L01.559.598.518'], ['F02.694', 'F04.096.586', 'L01.559.598.628'], ['E01.370.382.375.060.060.750'], ['F02.463.593.071.875', 'G07.888.125.875'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520... | ['Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Evidence for contribution by increased cytoplasmic Na+ to the insulinotropic action of PACAP38 in HIT-T15 cells. | Pituitary adenylate cyclase-activating polypeptide (PACAP) is localized to pancreatic nerve terminals and stimulates insulin secretion. The insulinotropic effect of PACAP38 in insulin-producing HIT-T15 cells is accompanied by increases in cellular cAMP and cytoplasmic Ca2+ ([Ca2+]cyt). As also intracellular Na+ is impo... | ['Animals', 'Cell Line', 'Cricetinae', 'Cytoplasm', 'Hydrogen-Ion Concentration', 'Insulin', 'Neuropeptides', 'Pituitary Adenylate Cyclase-Activating Polypeptide', 'Signal Transduction', 'Sodium'] | 9,829,998 | [['B01.050'], ['A11.251.210'], ['B01.050.150.900.649.313.992.635.075.250'], ['A11.284.430.214'], ['G02.300'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['D12.644.400', 'D12.776.631.650'], ['D12.644.276.860.887', 'D12.644.400.625', 'D12.776.467.860.887', 'D12.776.631.600.887', 'D12.776.631.650.625'... | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dentin evaluation after Nd:YAG laser irradiation using short and long pulses. | OBJECTIVE: Several reports have demonstrated the advantages of using the Nd:YAG laser to reduce dentin permeability by melting the dentin surface. A comparative study using different pulse durations can be useful to obtain further information about the laser-hard tissue interaction.MATERIALS AND METHODS: The present st... | ['Calcium', 'Dentin', 'Humans', 'In Vitro Techniques', 'Lasers', 'Microscopy, Electron, Scanning', 'Phosphorus', 'Radiation Dosage'] | 15,117,486 | [['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A14.549.167.900.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['E07.632.490', 'E07.710.520'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['D01.268.666'], ['E05.799.513', 'G01.750.740', 'N06.850.810.250']] | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Simian virus 40 agnoprotein facilitates perinuclear-nuclear localization of VP1, the major capsid protein. | The agnoprotein of simian virus 40 (SV40) is a 61-amino-acid protein encoded in the leader of some late mRNAs. In indirect immunofluorescence studies with antisera against SV40 capsid proteins, we show that mutants which make no agnoprotein display abnormal perinuclear-nuclear localization of VP1, the major capsid prot... | ['Capsid', 'Cell Compartmentation', 'Cell Nucleus', 'Fluorescent Antibody Technique', 'Morphogenesis', 'Mutation', 'Simian virus 40', 'Time Factors', 'Viral Proteins', 'Viral Regulatory and Accessory Proteins', 'Virus Replication'] | 3,023,658 | [['A21.249.500.250'], ['G04.128'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['E01.370.225.500.607.512.240', 'E01.370.225.750.551.512.240', 'E05.200.500.607.512.240', 'E05.200.750.551.512.240', 'E05.478.583.375'], ['G07.345.500'], ['G05.365.590'], ['B04.280.210.700.615.700', 'B04.613.204.670.615.700'], ['G01.... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Comparison of complication rates of porous anophthalmic orbital implants. | BACKGROUND AND OBJECTIVE: Porous anophthalmic orbital implants are used widely. This study evaluates risk factors for porous anophthalmic orbital implant complications and compares complication rates of hydroxyapatite, porous polyethylene, and polyglactin mesh-wrapped aluminum oxide implants.PATIENTS AND METHODS: The r... | ['Adult', 'Aged', 'Aged, 80 and over', 'Aluminum Oxide', 'Coated Materials, Biocompatible', 'Durapatite', 'Epidemiologic Methods', 'Eye Enucleation', 'Female', 'Humans', 'Male', 'Middle Aged', 'Orbital Implants', 'Polyethylenes', 'Polyglactin 910', 'Postoperative Complications', 'Young Adult'] | 21,899,247 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D01.056.050', 'D01.650.550.050'], ['D25.130.420', 'J01.637.051.130.420'], ['D01.029.260.700.675.374.075.025.300.150', 'D01.146.360.050.300.200', 'D01.578.122.477.300', 'D01.695.625.675.650.075.025.300.150'], ['E05.318', 'N06.850.520'], ['E04.540.429'], [... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
Anterior segment optical coherence tomography for the quantitative evaluation of the anterior segment following Boston keratoprosthesis. | OBJECTIVE: To quantitatively evaluate the anterior segment using anterior segment optical coherence tomography (AS-OCT) following Boston keratoprosthesis type 1.METHODS: A retrospective study consisted of AS-OCT imaging at a single time point postoperatively in 52 eyes. Main outcomes measures include anatomical and fun... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cornea', 'Corneal Diseases', 'Corneal Transplantation', 'Evaluation Studies as Topic', 'Female', 'Humans', 'Male', 'Middle Aged', 'Retrospective Studies', 'Tomography, Optical Coherence', 'Treatment Outcome', 'Visual Prosthesis', 'Young Adult'] | 23,940,621 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A09.371.060.217'], ['C11.204'], ['E02.095.147.725.225', 'E04.540.825.374', 'E04.936.580.225'], ['E05.337', 'N05.715.360.335'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E05.318.372.500.500.500', 'E05.318.372.500.750.750', 'N... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Terminal decline in cognitive function. | BACKGROUND: Impending death is thought to be associated with age-related cognitive decline, but this association has not been well studied.METHODS: Participants were 763 older Roman Catholic nuns, priests, and brothers without dementia at baseline. They completed an average of 5.6 annual evaluations (range 2 to 9), wit... | ['Age Factors', 'Aged', 'Cognition Disorders', 'Female', 'Follow-Up Studies', 'Humans', 'Male', 'Survival Analysis'] | 12,796,531 | [['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['F03.615.250'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.998', 'N05.715.360.750.795', 'N06.850.520.830.998']] | ['Health Care [N]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Social adjustment in in-patients with affective disorders: predictive factors. | We assessed social adjustment in 145 depressed in-patients using the self-reporting Social Adjustment Scale (42-item version) to evaluate the contribution of demographic and clinical variables and examine social functioning at different levels of depression. Our results indicate that the presence of a psychopathology i... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Bipolar Disorder', 'Depressive Disorder', 'Depressive Disorder, Major', 'Educational Status', 'Employment', 'Female', 'Humans', 'Inpatients', 'Male', 'Marital Status', 'Middle Aged', 'Social Adjustment'] | 12,113,919 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['F03.084.500'], ['F03.600.300'], ['F03.600.300.375'], ['N01.824.196'], ['N01.824.245'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.643.470'], ['F01.829.263.315.500', 'I01.240.361.500', 'I01.880.853.150.423.500', 'N01.224.361.5... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The relationship of astrocyte-like cells to the vessels that contribute to the blood-ocular barriers. | Brain capillaries form a selective interface, the blood-brain barrier (BBB), between the neural parenchyma and the blood. The factors which regulate this interface are poorly understood. Both the iris and retina possess vascular beds that express some BBB characteristics; therefore, they provide attractive models to fu... | ['ATP Binding Cassette Transporter, Subfamily B, Member 1', 'Animals', 'Astrocytes', 'Blood Proteins', 'Blood-Brain Barrier', 'Blood-Retinal Barrier', 'Carrier Proteins', 'Glial Fibrillary Acidic Protein', 'Immunohistochemistry', 'Iris', 'Male', 'Membrane Glycoproteins', 'Neuroglia', 'Rats', 'Rats, Wistar', 'Receptors,... | 7,906,600 | [['D12.776.157.530.100.075.063', 'D12.776.157.530.450.074.500.500.250.125', 'D12.776.395.550.020.400.153', 'D12.776.543.550.192.400.153', 'D12.776.543.585.100.200.125', 'D12.776.543.585.450.074.500.500.250.125'], ['B01.050'], ['A08.637.200', 'A11.650.200'], ['D12.776.124'], ['A07.035', 'A08.186.211.035'], ['A07.040', '... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Apomixis technology and the paradox of sex. | Most plant species produce genetically variable seeds by the fusion of meiotically reduced egg cells and pollen grains. However, a small proportion of seed plants produces clonal, asexual seeds by the process of apomixis. The fixation of heterosis by apomixis is of great interest for plant breeding. The prospect of cha... | ['Plant Physiological Phenomena', 'Plants', 'Seeds', 'Transgenes'] | 10,664,618 | [['G15'], ['B01.650'], ['A18.024.500.750', 'G07.203.300.775', 'J02.500.775'], ['G05.360.340.024.340.825']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Single-center experience with a dual microcatheter technique for the endovascular treatment of wide-necked aneurysms. | OBJECT: The endovascular treatment of wide-necked aneurysms can be technically challenging due to distal coil migration or impingement of the parent vessel. In this paper, the authors illustrate an alternative method for the treatment of wide-necked intracranial aneurysms using a dual microcatheter technique.METHODS: T... | ['Adult', 'Aged', 'Aged, 80 and over', 'Catheterization', 'Endovascular Procedures', 'Female', 'Follow-Up Studies', 'Humans', 'Intracranial Aneurysm', 'Male', 'Middle Aged', 'Postoperative Complications', 'Reoperation', 'Safety', 'Treatment Outcome'] | 25,148,003 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.148', 'E05.157'], ['E04.100.814.529', 'E04.502.382'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C10.228.140.300.510.600', 'C14.907.055.635', 'C14.907.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Immunolocalization of VEGF, VEGF receptors, EGF-R and Ki-67 in leiomyoma, cellular leiomyoma and leiomyosarcoma. | Angiogenic factors, such as vascular endothelial growth factor (VEGF), its receptors and epidermal growth factor receptor (EGF-R), are involved in increased progression in many carcinomas. The aim of this study was to investigate the role of angiogenesis and immunolocalization of VEGF, its receptors, EGF-R and Ki 67 in... | ['Adult', 'Aged', 'ErbB Receptors', 'Humans', 'Immunohistochemistry', 'Ki-67 Antigen', 'Leiomyoma', 'Leiomyosarcoma', 'Middle Aged', 'Neovascularization, Pathologic', 'Receptors, Vascular Endothelial Growth Factor', 'Vascular Endothelial Growth Factor A'] | 20,106,509 | [['M01.060.116'], ['M01.060.116.100'], ['D08.811.913.696.620.682.725.400.009', 'D12.776.543.750.630.009', 'D12.776.543.750.750.400.074'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Levels of p-tyramine in rat brain after chronic administration of MAO-inhibiting antidepressants. | Groups of male Sprague-Dawley rats were injected acutely or chronically with tranylcypromine (10 mg/kg i.p.) or phenelzine (15 mg/kg i.p.) and extracts of their brains were analyzed by electron-capture gas chromatography for concentrations of p-tyramine. Concentrations of p-tyramine were significantly higher than contr... | ['Animals', 'Brain', 'Male', 'Phenelzine', 'Rats', 'Rats, Inbred Strains', 'Tranylcypromine', 'Tyramine'] | 6,686,709 | [['B01.050'], ['A08.186.211'], ['D02.442.700'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992.635.505.700.400'], ['D02.092.831.845'], ['D02.092.211.215.811']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Treatment of experimental periodontitis with chlorhexidine as adjuvant to scaling and root planing. | OBJECTIVES: To assess whether subgingival irrigation with 0.12 % or 0.2 % chlorhexidine (CHX) immediately after scaling and root planing (SRP) enhances periodontal tissue repair compared to irrigation with saline solution (control).MATERIALS AND METHODS: Periodontitis was ligature-induced in rat molars for 7 days. Anim... | ['Animals', 'Chlorhexidine', 'Combined Modality Therapy', 'Dental Scaling', 'Disinfectants', 'Periodontitis', 'Rats', 'Root Planing'] | 31,759,184 | [['B01.050'], ['D02.078.370.141.100'], ['E02.186'], ['E06.721.189.350', 'E06.761.227.350'], ['D27.505.954.122.425', 'D27.720.274'], ['C07.465.714.533'], ['B01.050.150.900.649.313.992.635.505.700'], ['E06.721.189.350.650', 'E06.721.874.650', 'E06.761.227.350.650']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Aggregated IgG inhibits the differentiation of human fibrocytes. | Fibrocytes are fibroblast-like cells, which appear to participate in wound healing and are present in pathological lesions associated with asthma, pulmonary fibrosis, and scleroderma. Fibrocytes differentiate from CD14+ peripheral blood monocytes, and the presence of serum delays this process dramatically. We previousl... | ['Antibodies, Monoclonal', 'Biopolymers', 'Cell Differentiation', 'Cells, Cultured', 'Fibroblasts', 'Humans', 'Immunoglobulin A', 'Immunoglobulin E', 'Immunoglobulin Fc Fragments', 'Immunoglobulin G', 'Immunoglobulin M', 'Intracellular Signaling Peptides and Proteins', 'Monocytes', 'Phosphorylation', 'Protein Processin... | 16,543,402 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D05.750.078', 'D25.720.099', 'J01.637.051.720.099'], ['G04.152'], ['A11.251'], ['A11.329.228'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.026', 'D12.776.124.790.651.114.619.026', 'D12.7... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Evidence of chromosomal alterations in pure usual ductal hyperplasia as a breast carcinoma precursor. | Previous studies have shown the chromosomal alterations in usual ductal hyperplasia (UDH), atypical ductal hyperplasia (ADH), and ductal carcinoma in situ (DCIS) in the breast with bilateral ductal hyperplasia or adjacent to invasive ductal carcinoma (IDC). However, the role of UDH as a putative precursor of breast IDC... | ['Adult', 'Aged', 'Breast', 'Breast Neoplasms', 'Carcinoma, Ductal, Breast', 'Carcinoma, Intraductal, Noninfiltrating', 'Chromosome Aberrations', 'Chromosomes, Human', 'DNA, Neoplasm', 'Female', 'Humans', 'Hyperplasia', 'Lymphatic Metastasis', 'Middle Aged', 'Neoplasm Invasiveness', 'Precancerous Conditions'] | 18,497,952 | [['M01.060.116'], ['M01.060.116.100'], ['A01.236'], ['C04.588.180', 'C17.800.090.500'], ['C04.557.470.200.025.232.500', 'C04.557.470.615.132.500', 'C04.588.180.390', 'C17.800.090.500.390'], ['C04.557.470.200.025.275', 'C04.557.470.200.240.187.250', 'C04.557.470.615.275'], ['C23.550.210', 'G05.365.590.175'], ['A11.284.1... | ['Named Groups [M]', 'Anatomy [A]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Surgical treatment of lung cancer with chest wall invasion]. | From January 1986 to May 1998, 45 lung cancer patients with chest wall invasion (P3) underwent resection (40 male, 5 female), (median age 63.2 yrs (30-79)). Histological types were squamous cell carcinoma in 20, adenocarcinoma in 14, large cell carcinoma in 7, adenosquamous cell carcinoma in 2, and unknown in 2. Operat... | ['Adult', 'Aged', 'Chemotherapy, Adjuvant', 'Female', 'Humans', 'Lung Neoplasms', 'Male', 'Middle Aged', 'Neoplasm Invasiveness', 'Pneumonectomy', 'Preoperative Care', 'Radiotherapy, Adjuvant', 'Survival Rate', 'Thoracic Neoplasms', 'Thoracic Surgical Procedures', 'Treatment Outcome'] | 9,789,425 | [['M01.060.116'], ['M01.060.116.100'], ['E02.186.170', 'E02.319.170'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['M01.060.116.630'], ['C04.697.645', 'C23.550.727.645'], ['E04.620', 'E04.928.600.600'], ['E02.760.795', 'E04.604.750', 'N02.421.585.795'], ['E02... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Comparison of the prognostic value of regadenoson and adenosine myocardial perfusion imaging. | BACKGROUND: Regadenoson is now widely used in single-photon emission computed tomography (SPECT) myocardial perfusion imaging (MPI). However, the prognostic value of abnormal stress perfusion findings with regadenoson vs adenosine are unclear. The aim of this study was to evaluate the prognostic value of regadenoson SP... | ['Adenosine', 'Coronary Artery Disease', 'Death, Sudden, Cardiac', 'Exercise Test', 'Female', 'Humans', 'Incidence', 'Male', 'Middle Aged', 'Myocardial Perfusion Imaging', 'North Carolina', 'Prevalence', 'Prognosis', 'Purines', 'Pyrazoles', 'Reproducibility of Results', 'Retrospective Studies', 'Risk Assessment', 'Sens... | 25,987,234 | [['D03.633.100.759.590.138', 'D13.570.583.138', 'D13.570.800.096'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['C14.280.383.220', 'C23.550.260.322.250'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Named Groups [M]', 'Geographicals [Z]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Analysis of human tumor associated Thomsen-Friedenreich antigen. | The Thomsen-Friedenrich (TF) antigen is a precursor structure of MN blood group antigens and is also expressed by about 90% of human carcinomas. The immunodominant group of TF antigen [beta-galactosyl(1-3)-alpha-N-acetylglactosamine] is present in cryptic form in normal RBC and is revealed by neuraminidase treatment. A... | ['Antibodies, Monoclonal', 'Antigens, Neoplasm', 'Antigens, Tumor-Associated, Carbohydrate', 'Cell Line', 'Chromatography, Affinity', 'Chromatography, Gel', 'Disaccharides', 'Haptens', 'Humans', 'Immunoenzyme Techniques', 'Iodine Radioisotopes', 'Radioimmunoassay', 'Tumor Cells, Cultured'] | 2,196,117 | [['D12.776.124.486.485.114.224', 'D12.776.124.790.651.114.224', 'D12.776.377.715.548.114.224'], ['D23.050.285'], ['D23.050.285.050', 'D23.050.550.325', 'D23.101.140.075'], ['A11.251.210'], ['E05.196.181.400.170'], ['E05.196.181.400.250'], ['D09.698.629.305', 'D09.947.750'], ['D23.050.550.480'], ['B01.050.150.900.649.31... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Psychological needs underlying the creative process. | The 25-year follow-up study of the motivation underlying creativity of 10 highly creative women indicated that they create primarily to satisfy inner psychological needs for self-understanding, control, and mastery. | ['Adaptation, Psychological', 'Art', 'Creativity', 'Female', 'Humans', 'Internal-External Control', 'Motivation', 'Writing'] | 1,529,073 | [['F01.058'], ['K01.093'], ['F01.752.264', 'F02.463.785.302'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F01.829.379'], ['F01.658', 'F01.752.543.500.750'], ['L01.559.423.906']] | ['Psychiatry and Psychology [F]', 'Humanities [K]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Effects of physical training on the myocardium of streptozotocin-induced diabetic rats. | Effects of endurance swimming training on myocardial contractility and left ventricular myosin isoenzymes were examined in diabetic rats. A diabetic condition was induced in 15-week-old male Wistar rats, by intravenous injection of streptozotocin (50 mg/kg). Swimming training was carried out for five to six weeks (90 m... | ['Animals', 'Diabetes Mellitus, Experimental', 'Male', 'Myocardial Contraction', 'Myosins', 'Physical Exertion', 'Rats', 'Rats, Inbred Strains', 'Streptozocin', 'Swimming'] | 2,976,593 | [['B01.050'], ['C18.452.394.750.074', 'C19.246.240', 'E05.598.500.374'], ['G09.330.580', 'G11.427.494.570'], ['D05.750.078.730.475', 'D08.811.277.040.025.193.750', 'D12.776.210.500.600', 'D12.776.220.525.475'], ['G11.427.683'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.64... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 |
Intermediate conductance Ca2+-activated K+ channels modulate human placental trophoblast syncytialization. | Regulation of human placental syncytiotrophoblast renewal by cytotrophoblast migration, aggregation/fusion and differentiation is essential for successful pregnancy. In several tissues, these events are regulated by intermediate conductance Ca2+-activated K+ channels (IKCa), in part through their ability to regulate ce... | ['Analysis of Variance', 'Benzimidazoles', 'Biological Transport', 'Cell Culture Techniques', 'Cell Fusion', 'Chorionic Gonadotropin', 'Female', 'Fluorescent Antibody Technique', 'Humans', 'Linear Models', 'Placenta', 'Potassium Channels, Calcium-Activated', 'Pregnancy', 'Pyrazoles', 'Rubidium Radioisotopes', 'Trophobl... | 24,595,308 | [['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D03.633.100.103'], ['G03.143'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['E05.242.307', 'G04.155'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['E01.370.225.500.607.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
"He's probably overdosed on something!". | A 16 year old boy presented with extreme violent behaviour requiring physical restraint. Acute drug intoxication was mooted as a probable cause of his condition. The case illustrates that the causes of altered consciousness and aggressive behaviour are many and varied and that life-threatening conditions need to be con... | ['Adolescent', 'Diagnosis, Differential', 'Drug Overdose', 'Humans', 'Male', 'Meningitis, Meningococcal', 'Violence'] | 8,338,456 | [['M01.060.057'], ['E01.171'], ['C25.775.383', 'E02.319.306.500.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.150.252.223.500.750', 'C01.150.252.400.625.549.449', 'C01.207.180.500.750', 'C10.228.228.180.500.750', 'C10.228.614.280.505'], ['I01.198.240.856', 'I01.880.735.900']] | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
[123I]beta-CIT SPECT in multiple system atrophy, progressive supranuclear palsy, and corticobasal degeneration. | Differentiation between Parkinson's disease (PD) and other neurodegenerative disorders with parkinsonian features, such as multiple system atrophy (MSA), progressive supranuclear palsy (PSP), and corticobasal degeneration (CBD), is difficult on clinical grounds. We studied the pattern of dopaminergic degeneration in 18... | ['Adult', 'Aged', 'Aged, 80 and over', 'Basal Ganglia', 'Case-Control Studies', 'Cerebral Cortex', 'Cocaine', 'Diagnosis, Differential', 'Female', 'Humans', 'Image Processing, Computer-Assisted', 'Iodine Radioisotopes', 'Male', 'Middle Aged', 'Multiple System Atrophy', 'Neurodegenerative Diseases', 'Parkinson Disease',... | 11,104,200 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['A08.186.211.200.885.287.249'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['A08.186.211.200.885.287.500'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['E01.171'], ['B01.05... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Soluble adhesion molecules in juvenile rheumatoid arthritis. | OBJECTIVE: To determine serum levels of soluble (s) adhesion molecules in patients with juvenile rheumatoid arthritis (JRA), and to determine whether differences exist in these levels among the 3 subtypes of JRA, and whether levels of these molecules correlate with other measures of disease activity.METHODS: Serum leve... | ['Adolescent', 'Analysis of Variance', 'Antigens, CD', 'Antigens, Differentiation', 'Arthritis, Juvenile', 'Biomarkers', 'Cell Adhesion Molecules', 'Child', 'Child, Preschool', 'E-Selectin', 'Enzyme-Linked Immunosorbent Assay', 'Female', 'Humans', 'Intercellular Adhesion Molecule-1', 'L-Selectin', 'Male', 'Pilot Projec... | 10,493,690 | [['M01.060.057'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['D23.050.301.264.035', 'D23.101.100.110'], ['D23.050.301.264', 'D23.101.100'], ['C05.550.114.122', 'C05.799.056', 'C17.300.775.049', 'C20.111.198'], ['D23.101'], ['D12.776.395.550.200', 'D12.776.543.550.200', 'D23.050.301.350'], ['M01... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Detecting active methanogenic populations on rice roots using stable isotope probing. | Methane is formed on rice roots mainly by CO2 reduction. The present study aimed to identify the active methanogenic populations responsible for this process. Soil-free rice roots were incubated anaerobically under an atmosphere of H2/(13CO2) or N2/(13CO2) with phosphate or carbonate (marble) as buffer medium. Nucleic ... | ['Carbon Isotopes', 'Euryarchaeota', 'Methane', 'Oryza', 'Plant Roots', 'Polymorphism, Restriction Fragment Length', 'Sequence Analysis, DNA', 'Soil Microbiology'] | 15,683,393 | [['D01.268.150.075', 'D01.496.123'], ['B02.200'], ['D02.455.326.146.571'], ['B01.650.940.800.575.912.250.822.616'], ['A18.400'], ['G05.365.795.595'], ['E05.393.760.700'], ['H01.158.273.540.274.555', 'N06.850.425.300']] | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Mediation of the discriminative stimulus properties of 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) by the putative 5-HT1A receptor. | Male Sprague-Dawley rats were trained to discriminate the putative 5-HT1A receptor agonist, 8-hydroxy-2-(di-n-propylamino) tetralin (8-OH-DPAT) from saline in a 2-lever operant drug discrimination paradigm. The 8-OH-DPAT cue was found to be highly selective; neither the 5-HT receptor agonists, quipazine, LSD, MK 212 an... | ['8-Hydroxy-2-(di-n-propylamino)tetralin', 'Adrenergic alpha-Agonists', 'Adrenergic alpha-Antagonists', 'Alprenolol', 'Animals', 'Buspirone', 'Discrimination Learning', 'Dose-Response Relationship, Drug', 'Generalization, Psychological', 'Male', 'Naphthalenes', 'Pindolol', 'Pyrimidines', 'Rats', 'Rats, Inbred Strains',... | 2,881,789 | [['D02.455.426.559.847.638.960.400', 'D04.615.638.960.400'], ['D27.505.519.625.050.100.100', 'D27.505.696.577.050.100.100'], ['D27.505.519.625.050.200.100', 'D27.505.696.577.050.200.100'], ['D02.033.100.624.698.055', 'D02.033.755.624.698.055', 'D02.092.063.624.698.055'], ['B01.050'], ['D02.455.426.779.120', 'D03.383.60... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Streptococcus pneumoniae infection suppresses allergic airways disease by inducing regulatory T-cells. | An inverse association exists between some bacterial infections and the prevalence of asthma. We investigated whether Streptococcus pneumoniae infection protects against asthma using mouse models of ovalbumin (OVA)-induced allergic airway disease (AAD). Mice were intratracheally infected or treated with killed S. pneum... | ['Animals', 'Asthma', 'Bronchial Hyperreactivity', 'Humans', 'Hypersensitivity', 'Immune System', 'Inflammation', 'Interleukin-2 Receptor alpha Subunit', 'Lung', 'Mice', 'Mice, Inbred BALB C', 'Respiratory Hypersensitivity', 'Streptococcal Infections', 'Streptococcus pneumoniae', 'T-Lymphocytes', 'T-Lymphocytes, Regula... | 20,525,707 | [['B01.050'], ['C08.127.108', 'C08.381.495.108', 'C08.674.095', 'C20.543.480.680.095'], ['C08.127.210'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C20.543'], ['A15.382'], ['C23.550.470'], ['D12.776.543.750.705.852.420.320.500'], ['A04.411'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.52... | ['Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Differences in teenage pregnancy rates among five developed countries: the roles of sexual activity and contraceptive use. | CONTEXT: Adolescent pregnancy, birth, abortion and sexually transmitted disease (STD) rates are much higher in the United States than in most other developed countries.METHODS: Government statistics or nationally representative survey data were supplemented with data collected by private organizations or for regional o... | ['Abortion, Induced', 'Adolescent', 'Adolescent Behavior', 'Adult', 'Birth Rate', 'Canada', 'Coitus', 'Contraception Behavior', 'Developed Countries', 'Female', 'France', 'Humans', 'Maternal Age', 'Pregnancy', 'Pregnancy in Adolescence', 'Sexual Behavior', 'Sweden', 'United Kingdom', 'United States'] | 11,804,433 | [['E04.520.050'], ['M01.060.057'], ['F01.145.022'], ['M01.060.116'], ['E05.318.308.985.775.500', 'N01.224.935.849.500', 'N06.850.505.400.975.775.500', 'N06.850.520.308.985.775.500'], ['Z01.107.567.176'], ['F01.145.802.188', 'G08.686.784.041'], ['F01.145.688.500', 'G08.686.784.891.500'], ['I01.615.500.250'], ['Z01.542.2... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Development, growth, and biomass simulations of two common wetland tree species in Texas. | Monitoring the health and condition of wetlands using biological assessments can serve as an effective tool for environmental managers to better evaluate and monitor the status and trends of their wetland ecosystems. Woody species can be used as conspicuous biological assessment tools due to their direct response to en... | ['Biomass', 'Ecosystem', 'Environment', 'Environmental Monitoring', 'Hydrology', 'Salix', 'Texas', 'Trees', 'Wetlands'] | 30,112,684 | [['G16.500.275.157.100', 'N06.230.124.100'], ['G16.500.275.157', 'N06.230.124'], ['G16.500.275', 'N06.230'], ['N06.850.460.350.080', 'N06.850.780.375'], ['H01.158.273.248.875', 'H01.277.249.875', 'J01.293.622'], ['B01.650.940.800.575.912.250.859.797.875.833'], ['Z01.107.567.875.760.750'], ['B01.650.915'], ['G16.500.275... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
MPPa-PDT suppresses breast tumor migration/invasion by inhibiting Akt-NF-êB-dependent MMP-9 expression via ROS. | BACKGROUND: Breast cancer is one of the most commonly diagnosed cancers in women, with high morbidity and mortality. Tumor metastasis is implicated in most breast cancer deaths; thus, inhibiting metastasis may provide a therapeutic direction for breast cancer. In the present study, pyropheophorbide-á methyl ester-media... | ['Actins', 'Animals', 'Breast Neoplasms', 'Cell Movement', 'Cell Survival', 'Female', 'Gene Expression Regulation, Neoplastic', 'Humans', 'MCF-7 Cells', 'Matrix Metalloproteinase 9', 'Mice, Nude', 'Neoplasm Invasiveness', 'Neoplasm Metastasis', 'Phosphatidylinositol 3-Kinases', 'Phosphorylation', 'Photochemotherapy', '... | 31,783,821 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['C04.588.180', 'C17.800.090.500'], ['G04.198', 'G07.568.500.180'], ['G04.346'], ['G05.308.370'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.630'], ['D08.811.277.656.300.480.205.360', 'D08.811.277.656.300.480.25... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Medium's conductivity and stage of growth as crucial parameters for efficient hydrocarbon extraction by electric field from colonial micro-algae. | The green algae Botryococcus braunii produces a high amount of extracellular hydrocarbon, making it a promising algae in the field of bio-fuels production. As it mainly produces squalene like hydrocarbons, cosmetic industries are also interested in its milking. Pulsed electric fields (PEF) are an innovative method allo... | ['Biofuels', 'Cell Wall', 'Chlorophyta', 'Culture Media', 'Electric Conductivity', 'Electromagnetic Fields', 'Hydrocarbons', 'Squalene'] | 29,729,644 | [['D20.147', 'N06.230.132.644.124'], ['A11.284.183'], ['B01.650.940.150'], ['D27.720.470.305', 'E07.206'], ['G01.358.500.249.277'], ['G01.358.500.260', 'G01.358.750.500'], ['D02.455'], ['D02.455.326.271.665.806', 'D02.455.849.919.681']] | ['Chemicals and Drugs [D]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Regulation of antigen-specific versus by-stander IgE production after antigen sensitization. | IgE is critical in the pathogenesis of allergic disorders. In this report, we investigated the differential regulation of antigen-specific and by-stander IgE. Ovalbumin (OVA) immunization did not increase IgE producing cells in the spleen, but significantly enhanced the intracellular IgE content of all IgE+ cells. In c... | ['Adjuvants, Immunologic', 'Alum Compounds', 'Animals', 'Enzyme-Linked Immunosorbent Assay', 'Epitopes', 'Female', 'Flow Cytometry', 'Hypersensitivity', 'Immunoglobulin E', 'Immunoglobulin G', 'Interleukin-13', 'Interleukin-4', 'Lymph Nodes', 'Mice', 'Mice, Inbred BALB C', 'Ovalbumin', 'Specific Pathogen-Free Organisms... | 15,474,525 | [['D27.505.696.477.067'], ['D01.056.025', 'D01.875.800.800.850.025'], ['B01.050'], ['E05.478.566.350.170', 'E05.478.566.380.360', 'E05.478.583.400.170', 'E05.601.470.350.170', 'E05.601.470.380.360'], ['D23.050.550'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
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