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Human antibody response to N-glycans present on plant-made influenza virus-like particle (VLP) vaccines. | BACKGROUND: Plant-made biotherapeutics are gathering momentum and some plant glycoproteins are allergens. Glycans with core â1-2xylose and á1,3fucose motifs and antennae terminated by mannose residues (e.g.: MMXF) are found on several plant allergens and can cross-react with glyco-epitopes from other sources. To date, ... | ['Adolescent', 'Adult', 'Allergens', 'Antibody Formation', 'Cross Reactions', 'Double-Blind Method', 'Hemagglutination Inhibition Tests', 'Hemagglutinin Glycoproteins, Influenza Virus', 'Humans', 'Hypersensitivity', 'Immunoglobulin E', 'Immunoglobulin G', 'Influenza A virus', 'Influenza Vaccines', 'Middle Aged', 'Polys... | 25,240,757 | [['M01.060.057'], ['M01.060.116'], ['D23.050.063'], ['G12.450.050.370.250'], ['G12.122.281'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['E01.370.225.812.735.370', 'E05.200.812.735.370', 'E05.478.594.760.370'], ['D12.776.964.970.880.345.500'], ['B01.050.150.900.649.313.988.40... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Characteristics of gentamicin resistance in nosocomial infections. | Characteristics of gentamicin resistance were studied in gram-negative bacilli from 50 consecutive patients with nosocomial infection, during a time when gentamicin resistance had recently become prevalent at Medical University Hospital. Burns, decubitus ulcers, and cystic fibrosis were common precipitating factors for... | ['Amikacin', 'Cross Infection', 'Cross Reactions', 'Drug Resistance, Microbial', 'Electrophoresis, Agar Gel', 'Enterobacteriaceae', 'Gentamicins', 'Humans', 'Microbial Sensitivity Tests', 'Plasmids', 'Pseudomonas aeruginosa', 'Tobramycin'] | 6,768,292 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Growth promoting technologies reduce greenhouse gas, alcohol, and ammonia emissions from feedlot cattle. | Increased animal productivity has the potential to reduce the environmental impact per unit of consumable product and is believed to be the most promising and sustainable mitigation technique to meet increasing demand for high quality protein. The feedlot industry uses ionophores, antibiotics, growth implants, and â2-a... | ['Air Pollutants', 'Ammonia', 'Animal Feed', 'Animal Husbandry', 'Animal Nutritional Physiological Phenomena', 'Animals', 'Body Composition', 'Carbon Dioxide', 'Cattle', 'Diet', 'Ethanol', 'Feces', 'Greenhouse Effect', 'Growth Substances', 'Housing, Animal', 'Methane', 'Methanol', 'Monensin', 'Trimethylsilyl Compounds'... | 24,085,413 | [['D27.888.284.101'], ['D01.362.075', 'D01.625.050'], ['G07.203.300.300.100', 'J02.500.300.100'], ['J01.040.090'], ['G07.203.650.161'], ['B01.050'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['D01.200.200', 'D01.362.150', 'D01.650.550.200'], ['B01.050.150.900.649.313.500.380.271'], ['G07.203.650.240'], ['D02.033.375']... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Thalidomide and a thalidomide analogue drug costimulate virus-specific CD8+ T cells in vitro. | CD8(+) T cell immunity is critical for protection from viral disease, such as that caused by the human immunodeficiency virus (HIV) or cytomegalovirus (CMV). It is therefore important to identify therapies that can boost antiviral immunity. The recent finding that thalidomide acts as a T cell costimulator suggested tha... | ['Adjuvants, Immunologic', 'CD8-Positive T-Lymphocytes', 'Cell Division', 'Coculture Techniques', 'Cytokines', 'Cytomegalovirus Infections', 'Dendritic Cells', 'Dose-Response Relationship, Immunologic', 'Flow Cytometry', 'HIV Infections', 'Humans', 'Immunosorbent Techniques', 'Lenalidomide', 'Thalidomide'] | 12,660,941 | [['D27.505.696.477.067'], ['A11.118.637.555.567.569.220', 'A15.145.229.637.555.567.569.220', 'A15.382.490.555.567.569.220'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['E05.481.500.374'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['C01.925.256.466.245'], ['A11.066.270', 'A11... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Mesenchymal-epithelial interactions in bladder smooth muscle development: epithelial specificity. | PURPOSE: We previously showed that mesenchymal-epithelial interactions are necessary for the development of bladder smooth muscle. Specifically without bladder epithelium embryonic bladder mesenchyme does not differentiate into smooth muscle. We determine whether this process is specific to bladder epithelium or whethe... | ['Animals', 'Mesoderm', 'Rats', 'Rats, Inbred F344', 'Urinary Bladder', 'Urothelium'] | 9,719,273 | [['B01.050'], ['A16.504.660'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760.200', 'B01.050.150.900.649.313.992.635.505.700.400.200'], ['A05.810.890'], ['A10.272.850']] | ['Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Nucleotide sequence of Streptococcus mutans superoxide dismutase gene and isolation of insertion mutants. | A gene (sod) encoding superoxide dismutase (SOD) was cloned from Streptococcus mutans in Escherichia coli, and its nucleotide sequence was determined. The presumptive amino acid sequence of its product revealed that the SOD is basically of Mn type. Insertional inactivation of the sod gene resulted in the loss of SOD ac... | ['Amino Acid Sequence', 'Base Sequence', 'Blotting, Southern', 'Chromosome Mapping', 'Cloning, Molecular', 'DNA Transposable Elements', 'Genes, Bacterial', 'Molecular Sequence Data', 'Mutation', 'Streptococcus mutans', 'Superoxide Dismutase'] | 1,321,118 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['E05.393.183'], ['E05.393.220'], ['D13.444.308.520', 'G02.111.570.080.708.330.200', 'G05.360.080.708.330.200', 'G05.360.340.024.425.200'], ['G05.360.340.024.340... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Cardiovascular death and manic-depressive psychosis. | In order to study if tricyclic antidepressant drugs (TCA) in therapeutic doses increase the risk of death due to cardiovascular causes, the relative mortality from cardiovascular diseases was studied in two large groups of first hospitalized manic-depressive patients, one from the TCA era, the other from the period jus... | ['Antidepressive Agents, Tricyclic', 'Bipolar Disorder', 'Cardiovascular Diseases', 'Denmark', 'Humans', 'Male', 'Risk Factors'] | 2,960,722 | [['D27.505.954.427.700.122.055'], ['F03.084.500'], ['C14'], ['Z01.542.816.124'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.600.800.725', 'N05.715.350.200.700', 'N05.715.360.750.625.700.700', 'N06.850.490.625.750', 'N06.850.520.830.600.800.725']] | ['Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
Mechanisms involved in the development of resistance to fluoroquinolones in Escherichia coli isolates. | Eighteen quinolone-resistant isolates of Escherichia coli were selected by exposing ten clinical isolates to increasing concentrations of norfloxacin and lomefloxacin. The mutant isolates showed a multiple-antibiotic-resistance phenotype. All of them contained single mutations in gyrA consisting of the substitution of ... | ['Anti-Infective Agents', 'Bacterial Outer Membrane Proteins', 'DNA Topoisomerase IV', 'DNA Topoisomerases, Type II', 'Drug Resistance, Microbial', 'Drug Resistance, Multiple', 'Escherichia coli', 'Escherichia coli Infections', 'Fluoroquinolones', 'Humans', 'Lipopolysaccharides', 'Microbial Sensitivity Tests', 'Mutatio... | 10,590,273 | [['D27.505.954.122'], ['D12.776.097.120', 'D12.776.543.100'], ['D08.811.399.403.741.224', 'D12.776.097.256'], ['D08.811.399.403.741'], ['G06.225', 'G07.690.773.984.269'], ['G07.690.773.984.300'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['C01.150.252.400.310.330'], ['D03.633.100.810.835.322'], ['B01.050.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Percutaneous absorption of benzoic acid across human skin. II. Prediction of an in vivo, skin-flap system using in vitro parameters. | The possibility of predicting the behavior of in vivo systems based on physical and chemical parameters determined by in vitro experiments is examined using benzoic acid. The physical and chemical parameters governing percutaneous absorption of benzoic acid--permeability, partition coefficient, and skin thickness--were... | ['Animals', 'Benzoates', 'Benzoic Acid', 'Diffusion', 'Humans', 'In Vitro Techniques', 'Models, Biological', 'Rats', 'Regional Blood Flow', 'Skin', 'Skin Absorption', 'Tissue Distribution'] | 2,362,908 | [['B01.050'], ['D02.241.223.100', 'D02.455.426.559.389.127'], ['D02.241.223.100.120', 'D02.455.426.559.389.127.117'], ['G01.202', 'G02.196'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.481'], ['E05.599.395'], ['B01.050.150.900.649.313.992.635.505.700'], ['G09.330.100.780'], ['A17.815'], ['G03.015.500.750', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Evaluation of organ function monitoring and supporting during the treatment of multiple trauma]. | OBJECTIVE: To analyse the evaluation of organ function monitoring and supporting during the treatment of multiple trauma.METHODS: Eighty-eight patients with severe multiple trauma were admitted into Department of Intensive Care Unit(ICU) and the cardiovascular, respiratory, renal, and coagulation functions, milieu inte... | ['Accidents, Traffic', 'Adolescent', 'Adult', 'Aged', 'Brain Injuries', 'Child', 'Female', 'Fractures, Bone', 'Humans', 'Male', 'Middle Aged', 'Monitoring, Physiologic', 'Multiple Organ Failure', 'Multiple Trauma', 'Pelvic Bones'] | 12,212,171 | [['N06.850.135.392'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['M01.060.406'], ['C26.404'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.520'], ['C23.550.835.525'], ['C26.640'], ['A02.835.232.043.825']] | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ovarian fibrosarcoma with five-year survival: a case report. | A 45-year-old postmenopausal woman, Gravida6, Para4, Abortus0, Dilatation x Curhetage2, came to the gynaecology department with pelvic pain. The tumor had arisen in the right ovary and measured 15 x 12 x 7 cm. Its cut surface varied from grey-white with a whorled appearance and showed areas of haemorrhage. Histological... | ['Abdominal Pain', 'Appendectomy', 'Diagnosis, Differential', 'Female', 'Fibrosarcoma', 'Humans', 'Hysterectomy', 'Middle Aged', 'Omentum', 'Ovarian Neoplasms', 'Ovariectomy', 'Postmenopause', 'Salpingostomy', 'Survivors'] | 12,214,741 | [['C23.888.592.612.054', 'C23.888.821.030'], ['E04.210.078'], ['E01.171'], ['C04.557.450.565.590.350', 'C04.557.450.795.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E04.950.300.399'], ['M01.060.116.630'], ['A01.923.047.025.600.573'], ['C04.588.322.455', 'C13.351.500.056.630.705', 'C13.351.937.418.685', 'C1... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Inactivated Lactobacillus plantarum | Vaccination is considered the most effective strategy for controlling tuberculosis (TB). The existing vaccine, the Bacille Calmette-Gu?rin (BCG), although partially protective, has a number of limitations. Therefore, there is a need for developing new TB vaccines and several strategies are currently exploited including... | ['Animals', 'Antigens, Bacterial', 'BCG Vaccine', 'Bacterial Proteins', 'Cells, Cultured', 'Female', 'Humans', 'Immunity, Cellular', 'Immunization, Secondary', 'Lactobacillus plantarum', 'Leukocytes, Mononuclear', 'Mice', 'Mice, Inbred C57BL', 'Mycobacterium tuberculosis', 'Recombinant Fusion Proteins', 'T-Lymphocytes'... | 31,354,727 | [['B01.050'], ['D23.050.161'], ['D20.215.894.135.825.100'], ['D12.776.097'], ['A11.251'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G12.450.050.400'], ['E02.095.465.425.400.485', 'E05.478.550.550'], ['B03.353.750.450.475.612', 'B03.510.460.400.410.475.475.612', 'B03.510.550.450.475.612'], ['A11.118.637.555', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Fuji film and ultrasound measurement of total knee arthroplasty contact areas. | This article describes tibiofemoral contact area measurement results from tests on 1 commercial total knee arthroplasty (TKA) using 2 experimental methods-fuji film and diagnostic ultrasound. The study presents a novel diagnostic ultrasound technique developed specifically for measuring TKA contact areas. Because most ... | ['Arthroplasty, Replacement, Knee', 'Femur', 'Humans', 'Knee Prosthesis', 'Pressure', 'Tibia', 'Ultrasonography'] | 11,307,136 | [['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['A02.835.232.043.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.695.400.410'], ['G01.374.715'], ['A02.835.232.043.650.883'], ['E01.370.350.850']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Motion parallax is used to control postural sway during walking. | Three experiments tested the hypothesis that postural sway during locomotion is visually regulated by motion parallax as well as optical expansion. Oscillating displays of three-dimensional scenes were presented to participants walking on a treadmill, while postural sway was recorded. Displays simulated: (a) a cloud, i... | ['Adult', 'Analysis of Variance', 'Computer Simulation', 'Humans', 'Locomotion', 'Posture', 'Proprioception', 'Stochastic Processes', 'Vision Disparity'] | 8,891,657 | [['M01.060.116'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['L01.224.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G07.568.500', 'G11.427.410.568'], ['G11.427.695'], ['F02.830.816.541', 'G07.888.750', 'G11.561.790.541'], ['E05.318.740.996', 'G17.830', 'N05.715.360.750.770', 'N06.85... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Information Science [L]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Respiratory control in hyperpermeable adult heart muscle cells. Effects of calcium. | Spontaneously beating myocardial fragments prepared by mechanical disaggregation have hyperpermeable sarcolemmae. Such preparations were used to study mitochondrial function in situ. The myocardial fragments suspended in a phosphate-buffered salt solution containing 1-3 mM MgCl2 showed a low rate of oxygen uptake. Addi... | ['Animals', 'Calcium', 'Egtazic Acid', 'Heart', 'Kinetics', 'Mice', 'Mitochondria, Muscle', 'Myocardium', 'Oxygen Consumption', 'Permeability'] | 813,779 | [['B01.050'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D02.092.782.258.368.257', 'D02.241.081.018.269'], ['A07.541'], ['G01.374.661', 'G02.111.490'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.284.430.214.190.875.564.627', 'A11.284.835.626.627'], ['A02.633.580', 'A07.541.704', 'A10.690.552.750']... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Altered proximal aortic stiffness and endothelin plasma levels in diabetic patients with end-stage renal disease. | Peripheral artery stiffness is altered in diabetic patients with end-stage renal disease (ESRD), whereas few data exist to confirm this trend for proximal aortic stiffness. The pulse wave velocity of the proximal aorta (PWVr) and of the carotid-to-femoral aortic segment (PWVcf) were determined by ultrasound imaging in ... | ['Aged', 'Aortic Diseases', 'C-Reactive Protein', 'Cholesterol, HDL', 'Diabetic Angiopathies', 'Echocardiography', 'Endothelin-1', 'Female', 'Homocysteine', 'Humans', 'Kidney Failure, Chronic', 'Linear Models', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Pulsatile Flow', 'Triglycerides'] | 17,515,727 | [['M01.060.116.100'], ['C14.907.109'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.157'], ['D04.210.500.247.808.197.238', 'D10.532.432.400', 'D10.570.938.208.270', 'D12.776.521.479.470'], ['C14.907.320', 'C19.246.099.500'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['D12.644... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effect of dopamine and blockade of dopaminergic and adrenergic receptors on coronary blood flow in ischemic rabbit myocardium. | The effect of a broad dose range of dopamine on coronary blood flow was studied in rabbits with coronary artery occlusion. Dopaminergic and adrenergic receptor blockade was established to distinguish the mechanism of the dopamine-induced increase in coronary blood flow. Dopamine, 10, 100, or 1,000 micrograms/kg/min, wa... | ['Animals', 'Aporphines', 'Blood Gas Analysis', 'Blood Pressure', 'Coronary Circulation', 'Coronary Disease', 'Dopamine', 'Dose-Response Relationship, Drug', 'Heart Rate', 'Hemodynamics', 'Myocardium', 'Oxygen Consumption', 'Phenoxybenzamine', 'Practolol', 'Propranolol', 'Rats', 'Receptors, Adrenergic, beta', 'Receptor... | 2,410,711 | [['B01.050'], ['D03.132.098.038', 'D03.633.100.531.085.030', 'D03.633.400.095'], ['E01.370.225.124.100.100', 'E01.370.386.700.100', 'E05.200.124.100.100'], ['E01.370.600.875.249', 'G09.330.380.076'], ['G09.330.100.324'], ['C14.280.647.250', 'C14.907.585.250'], ['D02.092.211.215.406', 'D02.092.311.342', 'D02.455.426.559... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Synaptic depression depends on charge delivered to network. | In vitro neuronal networks cultured on microelectrode arrays enable the study of network electrophysiology on a fundamental level. Neuronal response to electrical stimulation is an area of interest at the laboratory bench and in the clinic, given its wide application for remedying neurological disorders. Here we invest... | ['Electric Stimulation', 'Humans', 'Long-Term Synaptic Depression', 'Microelectrodes', 'Nerve Net', 'Neurons'] | 28,268,679 | [['E05.723.402'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G11.561.638.355'], ['E07.305.250.500'], ['A08.511'], ['A08.675', 'A11.671']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
To repress: a note on an ambiguity of meaning. | An analysand used the word repress in a dream in an unusual way. In the dream, a record had been re-pressed: it was not the original disc but a copy. This manifest meaning of the word led associatively to more latent meanings. A kind of dialectical process ensued whereby, whenever the concept of repression came up, sev... | ['Humans', 'Psychoanalytic Therapy', 'Repression, Psychology', 'Semantics'] | 16,355,718 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.754.709'], ['F01.393.821'], ['L01.559.598.745']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Light-induced synchronous conidiation in the fungus Botrytis cinerea. | Botrytis cinerea Pers. ex Fr. in stationary liquid cultures conidiated asynchronously in darkness after 4 days' growth. Synchronous conidiation was induced by irradiating dark-grown cultures with near-ultraviolet light for 12 h. The number of conidia increased very rapidly 10 h after the end of the photo-induction peri... | ['Cell Division', 'Darkness', 'Light', 'Mitosporic Fungi', 'Radiation Effects', 'Spores, Fungal', 'Ultraviolet Rays'] | 945,324 | [['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['G01.590.540.233'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', 'G01.750.770.578'], ['B01.300.381'], ['G01.750.745', 'N06.850.810.300'], ['A11.870.710', 'A19.374.500', 'B05.775.710'], ['G01.358.500.505.650.891', 'G01.590.540.891',... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
ECG-derived cardiopulmonary analysis of pediatric sleep-disordered breathing. | BACKGROUND: The diagnosis of sleep-disordered breathing (SDB) and evaluation of sleep quality in the pediatric population is dependent on resource intensive attended polysomnography. An ECG-derived cardiopulmonary coupling sleep spectrogram (CPC) analysis previously described in adults can provide information about the... | ['Arousal', 'Child', 'Child, Preschool', 'Databases, Factual', 'Electrocardiography', 'Female', 'Humans', 'Male', 'Polysomnography', 'Pulse', 'Severity of Illness Index', 'Sleep Apnea Syndromes', 'Surveys and Questionnaires'] | 21,396,891 | [['F02.830.104', 'G11.561.035'], ['M01.060.406'], ['M01.060.406.448'], ['L01.313.500.750.300.188.400', 'L01.470.750.750'], ['E01.370.370.380.240', 'E01.370.405.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.520.625'], ['E01.370.370.380.650', 'G09.330.380.750'], ['E05.318.308.980.438.475.456.500', 'N0... | ['Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Named Groups [M]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Psychrophily is associated with differential energy partitioning, photosystem stoichiometry and polypeptide phosphorylation in Chlamydomonas raudensis. | Chlamydomonas raudensis UWO 241 and SAG 49.72 represent the psychrophilic and mesophilic strains of this green algal species. This novel discovery was exploited to assess the role of psychrophily in photoacclimation to growth temperature and growth irradiance. At their optimal growth temperatures of 8 degrees C and 28 ... | ['Acclimatization', 'Animals', 'Chlamydomonas', 'Cold Temperature', 'Energy Metabolism', 'Peptides', 'Phosphorylation', 'Photosystem II Protein Complex'] | 17,234,152 | [['G07.025.133', 'G16.012.500.133'], ['B01.050'], ['B01.650.940.150.385'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['G03.295'], ['D12.644'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['D05.500.562.488.750', 'D08.811.600.71... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Tuberculin reactivity: prevalence and predictors in BCG-vaccinated young Norwegian adults. | We studied tuberculin reactivity in young Norwegian adults and its possible dependency on age, gender, previous BCG vaccination, smoking habits, occupational exposure, diet as well as years of education as a measure of socio-economic status. Responders of a random sample of men and women aged 20-44 years living in Berg... | ['Adult', 'Age Factors', 'Ascorbic Acid', 'BCG Vaccine', 'Female', 'Humans', 'Hypersensitivity, Delayed', 'Male', 'Norway', 'Regression Analysis', 'Sex Factors', 'Smoking', 'Time Factors', 'Tuberculin Test'] | 12,477,220 | [['M01.060.116'], ['N05.715.350.075', 'N06.850.490.250'], ['D02.241.081.844.107', 'D02.241.511.902.107', 'D09.811.100'], ['D20.215.894.135.825.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C20.543.418'], ['Z01.542.816.374'], ['E05.318.740.750', 'N05.715.360.750.695', 'N06.850.520.830.750'], ['N05.715.350.67... | ['Named Groups [M]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Vasculature of various locations of canine gastrointestinal tract responds differently to intravenous isoproterenol. | In this study we investigated the relative vascular response of different locations of the gastrointestinal tract to continuous intravenous infusion of isoproterenol (0.1 microgram kg-1 min-1 for 10 min). The vascular response of some nonsplanchnic organs was also examined. Blood flow of the arteries was measured by el... | ['Animals', 'Colon', 'Dogs', 'Intestine, Small', 'Isoproterenol', 'Male', 'Microspheres', 'Muscles', 'Pancreas', 'Regional Blood Flow', 'Renal Circulation', 'Splanchnic Circulation', 'Spleen', 'Stomach', 'Vascular Resistance'] | 3,180,980 | [['B01.050'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['B01.050.150.900.649.313.750.250.216.200'], ['A03.556.124.684'], ['D02.033.100.291.439', 'D02.092.063.291.439', 'D02.092.311.649', 'D02.455.426.559.389.657.166.175.649'], ['E07.565'], ['A02.633', 'A10.690'], ['A03.734'], ['G09.330.100.780'], ['G08.852.725',... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Enhancement of cortical extracellular 5-HT by 5-HT1A and 5-HT2C receptor blockade restores the antidepressant-like effect of citalopram in non-responder mice. | We recently found that the response of DBA/2 mice to SSRIs in the forced swim test (FST) was impaired and they also had a smaller basal and citalopram-stimulated increase in brain extracellular serotonin (5-HT) than 'responder' strains. We employed intracerebral microdialysis, FST and selective antagonists of 5-HT1A an... | ['Aminopyridines', 'Analysis of Variance', 'Animals', 'Antidepressive Agents', 'Cerebral Cortex', 'Citalopram', 'Drug Interactions', 'Exploratory Behavior', 'Extracellular Fluid', 'Indoles', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Mice, Inbred DBA', 'Microdialysis', 'Piperazines', 'Pyridines', 'Serotonin', 'Serotonin 5-... | 19,123,962 | [['D02.092.080', 'D03.383.725.050'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['D27.505.954.427.700.122'], ['A08.186.211.200.885.287.500'], ['D02.092.831.170', 'D02.626.320', 'D03.633.100.127.187'], ['G07.690.773.968'], ['F01.145.387', 'F01.658.370'], ['A11.284.295.260', 'A12.207.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Variations in mechanical sampling: their causes and effects. | Three characteristics of a sample of AutoAnalyzer Sampler II modules have been measured: eccentricity of the cam, eccentricity of the spindle driving the cam, and the lengths of the chords of the cam lobes. Imprecision in timing may make a significant contribution to analytical error. | ['Autoanalysis', 'Data Interpretation, Statistical', 'Diagnostic Errors', 'Research Design', 'Time Factors', 'Urea'] | 15,637,910 | [['E05.059'], ['E05.245.380', 'E05.318.740.300', 'L01.313.500.750.190.380', 'N05.715.360.750.300', 'N06.850.520.830.300'], ['E01.354', 'N02.421.450.280'], ['E05.581.500', 'H01.770.644.728'], ['G01.910.857'], ['D02.065.950']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Injuries to the hand from dog bites. | A review of dog bite injuries referred to one surgeon over a 12 month period demonstrated a significant association between a delay in referral and a prolonged period of subsequent in-patient treatment. Two patients sustained injuries when delivering material through a letter-box. | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Amputation, Traumatic', 'Animals', 'Bites and Stings', 'Child', 'Child, Preschool', 'Dogs', 'Female', 'Hand Injuries', 'Humans', 'Male', 'Middle Aged', 'Treatment Outcome'] | 10,763,718 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['C26.062'], ['B01.050'], ['C25.723.127', 'C26.176'], ['M01.060.406'], ['M01.060.406.448'], ['B01.050.150.900.649.313.750.250.216.200'], ['C26.448'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.789.800', 'N0... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
ZNRD1 gene suppresses cell proliferation through cell cycle arrest in G1 phase. | ZNRD1, a transcription-associated gene, was recently found in our laboratory significantly suppress the cell proliferation of stomach cancer cells in vitro and in vivo. In this study, we firstly characterized ZNRD1 expression in a wide spectrum of gastric diseases by immunohistochemistry and RT-PCR. We also investigate... | ['Adenocarcinoma', 'Adult', 'Aged', 'Aged, 80 and over', 'Animals', 'Cell Proliferation', 'Cell Transformation, Neoplastic', 'DNA-Binding Proteins', 'Female', 'Fibroblasts', 'G1 Phase', 'Gene Expression Profiling', 'Humans', 'Immunohistochemistry', 'Male', 'Mice', 'Middle Aged', 'Reverse Transcriptase Polymerase Chain ... | 15,662,122 | [['C04.557.470.200.025'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B01.050'], ['G04.161.750', 'G07.345.249.410.750'], ['C04.697.098.500', 'C23.550.727.098.500'], ['D12.776.260'], ['A11.329.228'], ['G04.144.500.320'], ['E05.393.332'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
Demystifying knowledge translation: learning from the community. | OBJECTIVES: While there is increasing interest in research related to so-called Knowledge Translation, much of this research is undertaken from the perspective of researchers. The objective of this paper is to explore, through the participatory evaluation of Manitoba's The Need to Know Project, the characteristics of e... | ['Community Health Services', 'Cooperative Behavior', 'Health Knowledge, Attitudes, Practice', 'Humans', 'Information Dissemination', 'Interviews as Topic', 'Manitoba', 'National Health Programs', 'Rural Population'] | 16,259,686 | [['N02.421.143'], ['F01.145.813.115'], ['F01.100.150.500', 'N05.300.150.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.143.443'], ['E05.318.308.420', 'L01.399.250.520', 'N05.715.360.300.400', 'N06.850.520.308.420'], ['Z01.107.567.176.410'], ['N03.349.550'], ['N01.600.725']] | ['Health Care [N]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 1 |
Differential effect of DDT, DDE, and DDD on COX-2 expression in the human trophoblast derived HTR-8/SVneo cells. | The purpose of this study was to investigate the effect of 1,1,1-trichloro-2,2-bis-(chlorophenyl)ethane (DDT), 1,1-bis-(chlorophenyl)-2,2-dichloroethene (DDE), and 1,1-dichloro-2,2-bis(chlorophenyl)ethane (DDD) isomers on COX-2 expression in a human trophoblast-derived cell line. Cultured HTR-8/SVneo trophoblast cells ... | ['Carcinogens, Environmental', 'Cell Line', 'Cell Survival', 'Cyclooxygenase 2', 'DDT', 'Dichlorodiphenyl Dichloroethylene', 'Dichlorodiphenyldichloroethane', 'Dinoprostone', 'Enzyme Induction', 'Female', 'Humans', 'Insecticides', 'Osmolar Concentration', 'Protein Biosynthesis', 'RNA, Messenger', 'Stereoisomerism', 'Tr... | 23,132,776 | [['D27.888.569.100.125'], ['A11.251.210'], ['G04.346'], ['D08.811.600.720.750'], ['D02.455.526.439.255'], ['D02.455.526.439.292'], ['D02.455.526.439.294'], ['D10.251.355.255.550.250.200', 'D23.469.050.175.725.250.200'], ['G05.308.320.200'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D27.720.031.700.491', 'D27.8... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Temperature acceleration in cold oral stimulation. | This study measured the temperature acceleration of a cold probe as it contacts human tissue. Both the effects of touching a cold probe to the oral cavity were investigated. The results indicated a rapid warming pattern. This warming is effected first by temperature changes resulting from the probe being moved from ice... | ['Body Temperature', 'Cold Temperature', 'Deglutition', 'Deglutition Disorders', 'Humans', 'Mouth Mucosa', 'Physical Stimulation', 'Reflex', 'Thermosensing'] | 8,005,011 | [['E01.370.600.875.374', 'G07.110'], ['G01.906.595.272', 'G16.500.275.063.725.710.300', 'G16.500.750.775.710.300', 'N06.230.300.100.725.154', 'N06.230.300.100.725.710.300'], ['G10.261.178'], ['C06.405.117.119', 'C09.775.174'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.615.550.599', 'A14.549.512'], ['E05.72... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Audiological Results in SSD With an Active Transcutaneous Bone Conduction Implant at a Retrosigmoidal Position. | OBJECTIVE: One option for patients with single sided deafness (SSD) who experience problems with insufficient hearing in different surroundings is the treatment with percutaneous bone-anchored hearing aids. Common medical problems associated to a skin penetrating abutment can be avoided by active transcutaneous bone co... | ['Adult', 'Aged', 'Bone Conduction', 'Female', 'Hearing', 'Hearing Aids', 'Hearing Loss, Unilateral', 'Humans', 'Male', 'Middle Aged', 'Signal-To-Noise Ratio', 'Speech Intelligibility', 'Speech Perception'] | 28,375,939 | [['M01.060.116'], ['M01.060.116.100'], ['F02.830.816.263.500', 'G07.888.500.500', 'G11.561.790.263.398'], ['F02.830.816.263', 'G07.888.500', 'G11.561.790.263'], ['E07.305.906.500', 'E07.814.458'], ['C09.218.458.341.950', 'C10.597.751.418.341.950', 'C23.888.592.763.393.341.950'], ['B01.050.150.900.649.313.988.400.112.40... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Oscillatory coupling within neonatal prefrontal-hippocampal networks is independent of selective removal of GABAergic neurons in the hippocampus. | GABAergic neurons have been proposed to control oscillatory entrainment and cognitive processing in prefrontal-hippocampal networks. Co-activation of these networks emerges already during neonatal development, with hippocampal theta bursts driving prefrontal oscillations via axonal projections. The cellular substrate o... | ['Action Potentials', 'Animals', 'Animals, Newborn', 'GABAergic Neurons', 'Hippocampus', 'Male', 'Nerve Net', 'Neural Pathways', 'Neurons', 'Prefrontal Cortex', 'Rats', 'Theta Rhythm'] | 24,056,266 | [['G04.580.100', 'G07.265.675.100', 'G11.561.570.100'], ['B01.050'], ['B01.050.050.282'], ['A08.675.289', 'A11.671.285'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['A08.511'], ['A08.612'], ['A08.675', 'A11.671'], ['A08.186.211.200.885.287.500.270.700'], ['B01.050.150.900.649.313.992.635.505.700'], ['... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Glutamatergic regulation of extracellular citrulline levels in the nucleus accumbens during an emotional conditioned reflex. | Intracerebral microdialysis and high-performance liquid chromatography were used to demonstrate that the acquisition and execution of an emotional conditioned reflex in Sprague-Dawley rats are accompanied by increases in extracellular citrulline (a co-product of nitric oxide synthesis) levels in the nucleus accumbens. ... | ['Animals', 'Association Learning', 'Citrulline', 'Conditioning, Classical', 'Dizocilpine Maleate', 'Excitatory Amino Acid Antagonists', 'Extinction, Psychological', 'Extracellular Fluid', 'Male', 'Microdialysis', 'Nitric Oxide', 'Nitric Oxide Synthase', 'Nucleus Accumbens', 'Rats', 'Rats, Sprague-Dawley', 'Receptors, ... | 18,607,752 | [['B01.050'], ['F02.463.425.069.296'], ['D12.125.095.226'], ['F02.463.425.179.308'], ['D02.455.426.559.847.181.384.380', 'D04.615.181.384.380'], ['D27.505.519.625.190.300', 'D27.505.696.577.190.300'], ['F02.463.425.770.232'], ['A11.284.295.260', 'A12.207.270'], ['E05.196.353.500'], ['D01.339.387', 'D01.625.550.500', 'D... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Analysis of the transcripts encoding for antigenic proteins of bovine gammaherpesvirus 4. | The major glycoproteins of bovine gammaherpesvirus 4 (BoHV-4) are gB, gH, gM, gL, and gp180 with gB, gH, and gp180 being the most glycosylated. These glycoproteins participate in cell binding while some act as neutralization targets. Glycosylation of these envelope proteins may be involved in virion protection against ... | ['Animals', 'Antigens, Viral', 'Argentina', 'Cattle', 'Cattle Diseases', 'Deer', 'Female', 'Goat Diseases', 'Goats', 'Herpesviridae Infections', 'Herpesvirus 4, Bovine', 'Male', 'Sheep', 'Sheep Diseases', 'Transcription, Genetic', 'Tumor Virus Infections', 'Viral Proteins'] | 31,940,684 | [['B01.050'], ['D23.050.327'], ['Z01.107.757.077'], ['B01.050.150.900.649.313.500.380.271'], ['C22.196'], ['B01.050.150.900.649.313.500.380.373'], ['C22.405'], ['B01.050.150.900.649.313.500.380.513'], ['C01.925.256.466'], ['B04.280.210.400.700.300', 'B04.280.382.400.700.300', 'B04.613.204.500.700.300'], ['B01.050.150.9... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 |
Action of thyrotropin on phosphate incorporation into thyroid proteins in vitro. | It is now well established that cAMP is the intracellular mediator of many effects of thyrotropin on the thyroid. Greengard has postulated that all the effects of cAMP inside the cell are secondary to the phosphorylation of proteins by cAMP activated protein kinase(s). The purpose of our work is to define, in an intact... | ['Animals', 'Cyclic AMP', 'Dogs', 'Phosphates', 'Protein Kinases', 'Proteins', 'Thyroid Gland', 'Thyrotropin'] | 210,704 | [['B01.050'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['B01.050.150.900.649.313.750.250.216.200'], ['D01.029.260.700.675.374', 'D01.248.497.158.730', 'D01.695.625.675.650'], ['D08.811.913.696.620.682'], ['D12.776'], ['A06.300.900'], ['D06.472.699.631.525.883', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Direct binding to Rsp5p regulates ubiquitination-independent vacuolar transport of Sna3p. | The sorting of integral membrane proteins such as carboxypeptidase S (Cps1p) into the luminal vesicles of multivesicular bodies (MVBs) in Saccharomyces cerevisiae requires ubiquitination of their cytosolic domains by the ubiquitin ligases Rsp5p and/or Tul1p. An exception is Sna3p, which does not require ubiquitination ... | ['Amino Acid Sequence', 'Binding Sites', 'Biological Transport, Active', 'Carboxypeptidases', 'Endosomal Sorting Complexes Required for Transport', 'Genes, Fungal', 'Green Fluorescent Proteins', 'Membrane Proteins', 'Microscopy, Fluorescence', 'Molecular Sequence Data', 'Protein Structure, Tertiary', 'Recombinant Fusio... | 17,332,499 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.120'], ['G03.143.310'], ['D08.811.277.656.350.245'], ['D05.500.199', 'D12.776.543.990.493'], ['G05.360.340.024.340.364.500', 'G05.360.340.358.024.500', 'G05.360.340.358.365.500'], ['D12.776.532.265'], ['D12.776.543'], ['E01.370.350.515.458', 'E05.595.458'], ['L... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Bioactive Macrocyclic Inhibitors of the PD-1/PD-L1 Immune Checkpoint. | Blockade of the immunoinhibitory PD-1/PD-L1 pathway using monoclonal antibodies has shown impressive results with durable clinical antitumor responses. Anti-PD-1 and anti-PD-L1 antibodies have now been approved for the treatment of a number of tumor types, whereas the development of small molecules targeting immune che... | ['B7-H1 Antigen', 'Drug Discovery', 'Humans', 'Jurkat Cells', 'Macrocyclic Compounds', 'Molecular Docking Simulation', 'Peptides, Cyclic', 'Programmed Cell Death 1 Receptor', 'Protein Interaction Maps', 'T-Lymphocytes'] | 28,881,104 | [['D12.776.465.625', 'D12.776.467.150.300', 'D12.776.543.095.300', 'D23.050.301.285.400', 'D23.529.168.300'], ['E05.295', 'H01.158.703.007.675', 'H01.181.466.675'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.251.210.190.495', 'A11.251.860.180.495', 'A15.382.490.555.567.569.440'], ['D04.345'], ['E05.599.595.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anatomy [A]', 'Information Science [L]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Congenital paravertebral arteriovenous fistulae in children and adolescents]. | These arteriovenous fistulae (AVF) situated in the paravertebral area present as a murmur which explains their cardiological orientation. They are characterised by the presence of one or more afferent paravertebral arteries giving rise to collateral vessels irrigating the bone marrow. The aim of this study of 13 cases ... | ['Adolescent', 'Angiography', 'Arteriovenous Malformations', 'Cervical Vertebrae', 'Child', 'Child, Preschool', 'Embolization, Therapeutic', 'Female', 'Humans', 'Infant', 'Infant, Newborn', 'Lumbar Vertebrae', 'Male', 'Spine', 'Thoracic Vertebrae', 'Time Factors'] | 3,092,765 | [['M01.060.057'], ['E01.370.350.700.060', 'E01.370.370.050'], ['C14.240.850.750', 'C14.907.150', 'C16.131.240.850.750'], ['A02.835.232.834.151'], ['M01.060.406'], ['M01.060.406.448'], ['E02.520.360', 'E02.926.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['A02.835.232.834... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The interactome of the histone gene regulatory factor HiNF-P suggests novel cell cycle related roles in transcriptional control and RNA processing. | HiNF-P is a recently identified histone H4 subtype specific transcriptional regulator that associates with the conserved cell cycle control element in the proximal promoter regions of histone H4 genes. HiNF-P interacts with the global histone gene regulator and direct cyclin E/CDK2 substrate p220(NPAT) to potently upre... | ['Cell Cycle', 'Cell Line, Tumor', 'Cell Proliferation', 'Chromosomal Proteins, Non-Histone', 'Gene Expression Regulation', 'Humans', 'Ki-67 Antigen', 'RNA Processing, Post-Transcriptional', 'RNA-Binding Proteins', 'Repressor Proteins', 'Transcription, Genetic', 'Two-Hybrid System Techniques'] | 17,577,209 | [['G04.144'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['D12.776.660.235', 'D12.776.664.235'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.660.625.500', 'D23.050.290.500', 'D23.101.140.400'], ['G02.111.760', 'G03.839', 'G05.308.700'], ['D12.776.157.725'... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[A PCR-RFLP analysis to HLA-B gene among Chinese northern Han populations]. | OBJECTIVE: To set up the method for analyzing HLA-B gene polymorphism with PCR-RFLP, and to gain population data among northern Chinese Hans of HLA-B's restricted fragments after NlaIII digestion, and to achieve application in forensic medicine practice.METHODS: Sample DNA was extracted by the phenol/chloroform extract... | ['Asian Continental Ancestry Group', 'Base Sequence', 'China', 'DNA', 'Exons', 'Forensic Medicine', 'Gene Frequency', 'HLA-B Antigens', 'Humans', 'Polymerase Chain Reaction', 'Polymorphism, Restriction Fragment Length'] | 16,856,341 | [['M01.686.508.200'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['Z01.252.474.164'], ['D13.444.308'], ['G05.360.340.024.340.137.232'], ['H02.403.330', 'I01.198.780.937'], ['G05.330'], ['D12.776.395.550.489.500', 'D12.776.543.550.439.500', 'D23.050.301.500.100.500', 'D23.050.301.500.450.380', 'D23.050.7... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 1 |
CRISPR-Cas9 Toolkit for Actinomycete Genome Editing. | Bacteria of the order Actinomycetales are one of the most important sources of bioactive natural products, which are the source of many drugs. However, many of them still lack efficient genome editing methods, some strains even cannot be manipulated at all. This restricts systematic metabolic engineering approaches for... | ['Actinobacteria', 'CRISPR-Cas Systems', 'Cloning, Molecular', 'Computational Biology', 'DNA Breaks, Double-Stranded', 'DNA Repair', 'Gene Editing', 'Gene Knockdown Techniques', 'Genetic Vectors', 'Genome, Bacterial', 'Genomics', 'Loss of Function Mutation', 'Multigene Family', 'Software'] | 29,170,959 | [['B03.510.024', 'B03.510.460.400.400.049'], ['G05.308.203.374.394'], ['E05.393.220'], ['H01.158.273.180', 'L01.313.124'], ['G05.200.210.220'], ['G02.111.222', 'G05.219'], ['E05.393.420.270'], ['E05.393.335.500'], ['G05.360.337'], ['G05.360.340.358.207'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['G05.365.590.53... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Information Science [L]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
[Effect of nucleophiles on the conversion of choline esters under the action of cholinesterase]. | It is shown that effect of alcohols ROH on the hydrolysis of butyryl-choline and acetylcholine by choline esterase (E. C. 3.1.1.8) is complex; it included the concurrent and the unconcurrent inhibitions, the interaction with the acylenzyme to form more reactive triple complex, and the acyl migration. By titrometric met... | ['Acetylcholine', 'Acylation', 'Alcohols', 'Animals', 'Catalysis', 'Choline', 'Cholinesterases', 'Chymotrypsin', 'Esters', 'Horses', 'Hydrogen-Ion Concentration', 'Hydrolysis', 'Kinetics'] | 237,583 | [['D02.092.211.111'], ['G02.111.012', 'G02.607.063', 'G03.040'], ['D02.033'], ['B01.050'], ['G02.130'], ['D02.033.100.291.211', 'D02.092.063.291.211', 'D02.092.877.883.333', 'D02.675.276.232'], ['D08.811.277.352.100.170'], ['D08.811.277.656.300.760.176', 'D08.811.277.656.959.350.176'], ['D02.241.400'], ['B01.050.150.90... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
One hospital's success with home-based work stations. | This article describes background history and experiences in setting up a successful home-based transcription program at a tertiary care outpatient center. It traces how the authors first became involved in home transcription to facilitate more office personnel to work overtime and decrease transcription backlog. The a... | ['Electronic Data Processing', 'Hospital Bed Capacity, 500 and over', 'Hospital Departments', 'Medical Records Department, Hospital', 'Personnel Management', 'Personnel Staffing and Scheduling', 'Wisconsin', 'Workforce'] | 10,278,912 | [['L01.224.085'], ['N02.278.306.472.300'], ['N02.278.216.500.968', 'N04.452.442.452.422'], ['N02.278.216.500.968.465', 'N04.452.442.452.422.465'], ['N04.452.677'], ['I03.946.225', 'N04.452.677.650'], ['Z01.107.567.875.350.900', 'Z01.107.567.875.510.900'], ['N04.452.525']] | ['Information Science [L]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 1 |
Reconstructed three-dimensional images of flow-sorted nuclei hybridized with chromosome-specific probes. | We demonstrated that the three-dimensional (3-D) locational and morphological differences of chromosome 17 are dependent on each cell cycle phase in the clinical materials. Cell suspensions prepared from hypertrophied tonsil were hybridized with chromosome 17 whole painting probe or its centromeric probe and the probes... | ['Biomarkers', 'Cell Cycle', 'Cell Nucleus', 'Chromosomes, Human, Pair 17', 'Flow Cytometry', 'Humans', 'Image Processing, Computer-Assisted', 'In Situ Hybridization, Fluorescence', 'Microscopy, Confocal', 'Palatine Tonsil'] | 8,918,909 | [['D23.101'], ['G04.144'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['A11.284.187.520.300.415.425', 'G05.360.162.520.300.415.425'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.200.500.363.342', 'E05.200.500.386.350', 'E05.242.363.342', 'E05.242.386.350'], ['B01.... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Information Science [L]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Association of adverse drug reaction to anti-tuberculosis medication with quality of life in patients in a tertiary referral hospital. | INTRODUCTION: Adverse drug reactions can develop when using anti-tuberculosis medication, and the effects of the drugs can also significantly hinder the treatment of patients.METHODS: A cross-sectional survey was conducted in 73 patients using two standardized questionnaires and the World Health Organization Quality of... | ['Aged', 'Antitubercular Agents', 'Cross-Sectional Studies', 'Drug-Related Side Effects and Adverse Reactions', 'Female', 'Humans', 'Male', 'Middle Aged', 'Quality of Life', 'Socioeconomic Factors', 'Surveys and Questionnaires', 'Tertiary Care Centers', 'Tuberculosis'] | 31,859,946 | [['M01.060.116.100'], ['D27.505.954.122.085.255'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['C25.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['I01.800', 'K01.752.400.750', 'N06.850.505.400.425.837'], ['I01.880.853.996', 'N01.824'], ['E05.318.308.98... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Overexpression of Csk-binding protein contributes to renal cell carcinogenesis. | C-terminal Src kinase (Csk)-binding protein (Cbp) is a transmembrane adaptor protein that localizes exclusively in lipid rafts, where it regulates Src family kinase (SFK) activities through recruitment of Csk. Although SFKs are well known for their involvement in cancer, the function of Cbp in carcinogenesis remains la... | ['Actins', 'Adaptor Proteins, Signal Transducing', 'Amino Acid Motifs', 'Animals', 'Carcinoma, Renal Cell', 'Cell Line, Tumor', 'Cell Movement', 'Cell Proliferation', 'Cell Shape', 'Cell Transformation, Neoplastic', 'Cytoskeleton', 'Enzyme Activation', 'Female', 'Gene Expression Regulation, Neoplastic', 'Gene Knockdown... | 19,581,936 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['D12.644.360.024', 'D12.776.157.057', 'D12.776.476.024'], ['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['B01.050'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.93... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Development of a pneumatic tensioning device for gap measurement during total knee arthroplasty. | BACKGROUND: Despite the importance of soft tissue balancing during total knee arthroplasty (TKA), all estimating techniques are dependent on a surgeon's manual distraction force or subjective feeling based on experience. We developed a new device for dynamic gap balancing, which can offer constant load to the gap betwe... | ['Arthroplasty, Replacement, Knee', 'Biomechanical Phenomena', 'Equipment Design', 'Femur', 'Humans', 'Knee Joint', 'Mechanical Phenomena', 'Range of Motion, Articular', 'Reproducibility of Results', 'Tibia'] | 22,949,949 | [['E04.555.110.110.115', 'E04.650.110.115', 'E04.680.101.110.115'], ['G01.154.090', 'G01.374.089'], ['E05.320'], ['A02.835.232.043.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.583.475'], ['G01.374'], ['E01.370.600.700', 'G11.427.760'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
On the mechanism for PPAR agonists to enhance ABCA1 gene expression. | Expression of ATP binding cassette transporter A1 (ABCA1), a major regulator of high density lipoprotein (HDL) biogenesis, is known to be up-regulated by the transcription factor liver X receptor (LXR) alpha, and expression is further enhanced by activation of the peroxisome proliferator activated receptors (PPARs). We... | ['ATP Binding Cassette Transporter 1', 'ATP-Binding Cassette Transporters', 'Animals', 'Bezafibrate', 'Cell Line, Tumor', 'Fenofibrate', 'Fibroblasts', 'Gemfibrozil', 'Gene Expression Regulation', 'Humans', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'PPAR delta', 'PPAR gamma', 'Pioglitazone', 'Propionates', 'Thi... | 19,201,410 | [['D12.776.157.530.100.050.500', 'D12.776.395.550.020.381.500', 'D12.776.543.550.192.381.500', 'D12.776.543.585.100.190.500'], ['D12.776.157.530.100', 'D12.776.395.550.020', 'D12.776.543.550.192', 'D12.776.543.585.100'], ['B01.050'], ['D02.065.277.067', 'D02.241.081.114.968.500.249', 'D02.241.223.100.100.120', 'D02.241... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A comparative analysis of personality pathology profiles among patients with pure depressive-, pure anxiety-, and pure somatoform disorders. | BACKGROUND: Depressive-, anxiety-, and somatoform disorders are among the most common psychiatric disorders. The assessment of comorbid personality pathology or traits in these disorders is relevant, because it can lead to the exacerbation of them or to poorer remission rates. To date, no research findings have been pu... | ['Adolescent', 'Adult', 'Anxiety Disorders', 'Comorbidity', 'Cross-Sectional Studies', 'Depressive Disorder', 'Female', 'Humans', 'Male', 'Middle Aged', 'Personality Disorders', 'Psychiatric Status Rating Scales', 'Somatoform Disorders', 'Young Adult'] | 25,086,291 | [['M01.060.057'], ['M01.060.116'], ['F03.080'], ['N05.715.350.225', 'N06.850.490.687'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F03.600.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['F03.675'], ['F04.711.513.653'], ['F03.875'], ['M01.060.116.815']... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Effects of gaseous sulfur dioxide and its derivatives on the expression of KATP, BKCa and L-Ca(2+) channels in rat aortas in vitro. | Epidemiological investigations have revealed that sulfur dioxide (SO2) exposure is linked to cardiovascular diseases. Our previous study indicated that the vasorelaxant effect of SO2 might be partly related to ATP-sensitive K(+) (KATP), big-conductance Ca(2+)-activated K(+) (BKCa) and L-type calcium (L-Ca(2+)) channels... | ['Air Pollutants', 'Animals', 'Aorta', 'Calcium Channels, L-Type', 'Gene Expression', 'In Vitro Techniques', 'KATP Channels', 'Large-Conductance Calcium-Activated Potassium Channel alpha Subunits', 'Male', 'Protein Subunits', 'RNA, Messenger', 'Rats', 'Rats, Wistar', 'Sulfur Dioxide', 'Vasodilation'] | 25,192,964 | [['D27.888.284.101'], ['B01.050'], ['A07.015.114.056'], ['D12.776.157.530.400.150.400', 'D12.776.543.550.450.150.400', 'D12.776.543.585.400.150.400'], ['G05.297'], ['E05.481'], ['D12.776.157.530.400.600.450.550', 'D12.776.543.550.450.750.450.550', 'D12.776.543.585.400.750.450.550'], ['D12.776.157.530.400.600.150.500.50... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Localization of the heptapeptide GFSKLYFamide in the sea cucumber Holothuria glaberrima (Echinodermata): a light and electron microscopic study. | Two peptides, Gly-Phe-Ser-Lys-Leu-Tyr-Phe-NH2 (GFSKLYFamide) and Ser-Gly-Tyr-Ser-Val-Leu-Tyr-Phe-NH2 (SGYSVLYFamide), recently isolated from the sea cucumber Holothuria glaberrima [D?az-Miranda et al. (1992) Biol. Bull. 182:241-247] represent the first neuropeptides isolated from holothurians. Using an antibody against... | ['Animals', 'Antibody Formation', 'FMRFamide', 'Immunohistochemistry', 'Invertebrate Hormones', 'Microscopy, Electron', 'Nervous System Physiological Phenomena', 'Neuropeptides', 'Neurotransmitter Agents', 'Sea Cucumbers'] | 7,722,004 | [['B01.050'], ['G12.450.050.370.250'], ['D12.644.400.235', 'D12.776.631.650.235'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.100.656.234.512', 'H01.158.201.344.512', 'H01.158.201.486.512', 'H01.181.122.573.512', 'H01.181.122.605.512'], [... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Management of a new isolated metastasis during sunitinib treatment in renal cell carcinoma patients: a lesson from two cases. | Metastatic renal cell carcinoma (mRCC) is a difficult to treat malignancy and currently Sunitinib is a standard of care first-line therapy. A new metastasis during the treatment is considered a sign of drug failure and alternative therapeutic methods should be tried. Here, we report 2 cases of newly diagnosed isolated ... | ['Aged', 'Antineoplastic Agents', 'Carcinoma, Renal Cell', 'Combined Modality Therapy', 'Humans', 'Indoles', 'Kidney Neoplasms', 'Lymphatic Metastasis', 'Magnetic Resonance Imaging', 'Male', 'Medical Oncology', 'Neoplasm Metastasis', 'Palliative Care', 'Pyrroles', 'Radiation-Sensitizing Agents', 'Sunitinib', 'Tomograph... | 21,124,010 | [['M01.060.116.100'], ['D27.505.954.248'], ['C04.557.470.200.025.390', 'C04.588.945.947.535.160', 'C12.758.820.750.160', 'C12.777.419.473.160', 'C13.351.937.820.535.160', 'C13.351.968.419.473.160'], ['E02.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473'], ['C04.588.945.947.535', 'C12.758.820.7... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
eHealth Services for the European Reference Network on Rare Anaemias (eENERCA). | This paper presents an electronic registry system for the purposes of the eENERCA for rare congenital conditions that require lifelong follow up and treatment. The main objective of the eENERCA project focusses on the prevention of major rare anaemias (RAs) by facilitating the access, at a European level, to the best g... | ['Anemia', 'Congenital Abnormalities', 'Europe', 'Humans', 'Rare Diseases', 'Registries', 'Socioeconomic Factors'] | 26,152,979 | [['C15.378.071'], ['C16.131'], ['Z01.542'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.291.906'], ['E05.318.308.970', 'N04.452.859.819', 'N05.715.360.300.715.700', 'N06.850.520.308.970'], ['I01.880.853.996', 'N01.824']] | ['Diseases [C]', 'Geographicals [Z]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Radiomic Profiling of Head and Neck Cancer: 18 | Background and Purpose: The accurate prediction of prognosis and pattern of failure is crucial for optimizing treatment strategies for patients with cancer, and early evidence suggests that image texture analysis has great potential in predicting outcome both in terms of local control and treatment toxicity. The aim of... | ['Adult', 'Aged', 'Aged, 80 and over', 'Chemoradiotherapy', 'Female', 'Fluorodeoxyglucose F18', 'Head and Neck Neoplasms', 'Humans', 'Image Interpretation, Computer-Assisted', 'Male', 'Middle Aged', 'Positron-Emission Tomography', 'Prognosis', 'Radionuclide Imaging', 'Retrospective Studies', 'Survival Analysis', 'Young... | 30,363,632 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E02.186.079', 'E02.319.164', 'E02.815.160'], ['D09.254.229.500'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['M01.060.116.630'], ['E01.370.350.350.800.700', 'E01.3... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Chlorogenic acid decreases intestinal permeability and increases expression of intestinal tight junction proteins in weaned rats challenged with LPS. | Chlorogenic acid, a natural phenolic acid present in fruits and plants, provides beneficial effects for human health. The objectives of this study were to investigate whether chlorogenic acid (CHA) could improve the intestinal barrier integrity for weaned rats with lipopolysaccharide (LPS) challenge. Thirty-two weaned ... | ['Animals', 'Blotting, Western', 'Chlorogenic Acid', 'Cytokines', 'Humans', 'Immunohistochemistry', 'Inflammation', 'Intestines', 'Lipopolysaccharides', 'Male', 'Occludin', 'Permeability', 'Rats, Sprague-Dawley', 'Tight Junction Proteins', 'Weaning', 'Zonula Occludens-1 Protein'] | 24,887,396 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D02.241.223.200.185', 'D02.241.223.268.220'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512'... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Production of reactive oxygen species (ROS) by various marine fish species during the larval stage. | Previous studies have indicated that the devil stinger produces reactive oxygen species (ROS) during early development from fertilized egg to larva. To determine whether ROS generation is a common feature in marine fish species, we conducted chemiluminescence analysis using ROS specific probe (L012) on larvae of six ma... | ['Animals', 'Fishes', 'Larva', 'Luminescent Measurements', 'Reactive Oxygen Species', 'Species Specificity', 'Superoxide Dismutase', 'Tissue Distribution'] | 17,690,462 | [['B01.050'], ['B01.050.150.900.493'], ['B05.500.500', 'G07.345.500.550.500.500'], ['E05.196.712.516'], ['D01.339.431', 'D01.650.775'], ['G16.824'], ['D08.811.682.881'], ['G03.787.917', 'G07.690.725.949']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prognostic significance of karyotype analysis in children with acute lymphoblastic leukemia. | Chromosome studies, using bone marrow samples of 26 pretreated children (below 15 years of age) with Acute Lymphoblastic Leukemia were carried out to explore the potentialities of applying chromosomal findings as a prognostic indicator in these patients. Abnormal karyotype was identified in 15 patients (57.6 per cent).... | ['Adolescent', 'Child', 'Child, Preschool', 'Chromosome Aberrations', 'Chromosome Deletion', 'Chromosomes, Human, Pair 11', 'Chromosomes, Human, Pair 18', 'Chromosomes, Human, Pair 21', 'Chromosomes, Human, Pair 4', 'Chromosomes, Human, Pair 6', 'Chromosomes, Human, Pair 8', 'Female', 'Humans', 'Karyotyping', 'Male', '... | 1,296,934 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.210', 'G05.365.590.175'], ['C23.550.210.050.500.500', 'G05.365.590.029.530.175', 'G05.365.590.175.050.500.500', 'G05.365.590.762.180', 'G05.558.800.180', 'G05.700.131.500.500'], ['A11.284.187.520.300.325.355', 'G05.360.162.520.300.325.355'], ['A11.284.18... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
The use of retrosternally placed colon in esophageal replacement. | The authors present a review article evaluating the use of the colon as a replacement for the esophagus. We present current indications for both benign and malignant conditions and compare the advantages and disadvantages of the technical possibilities of esophageal reconstruction. The surgical technique utilizing the ... | ['Anastomosis, Surgical', 'Colon', 'Esophagus', 'Humans', 'Postoperative Complications'] | 30,442,011 | [['E04.035'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['A03.556.875.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.767']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The c.657del5 variant in the NBN gene predisposes to pancreatic cancer. | Pancreatic ductal adenocarcinoma (PDAC) is the sixth most frequent cancer type in the Czech Republic with a poor prognosis that could be improved by an early detection and subsequent surgical treatment combined with chemotherapy. Genetic factors play an important role in PDAC risk. We previously identified one PDAC pat... | ['Adenocarcinoma', 'Carcinoma, Pancreatic Ductal', 'Cell Cycle Proteins', 'Czechoslovakia', 'Female', 'Gene Deletion', 'Genetic Predisposition to Disease', 'Humans', 'Male', 'Middle Aged', 'Nuclear Proteins', 'Pancreatic Neoplasms', 'Pedigree'] | 27,150,568 | [['C04.557.470.200.025'], ['C04.557.470.200.025.232.750', 'C04.557.470.615.132.750', 'C04.588.274.761.750', 'C04.588.322.475.750', 'C06.301.761.750', 'C06.689.667.625', 'C19.344.421.750'], ['D12.776.167'], ['Z01.586.250'], ['G05.365.590.762.320', 'G05.558.800.320'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Geographicals [Z]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 |
Variability of Australopithecus second maxillary molars from Sterkfontein Member 4. | The question of how many Australopithecus species lived at Sterkfontein Member 4 and Makapansgat continues to be controversial inasmuch as the fossils are poorly preserved, the stratigraphy is difficult to interpret, and the cranial, dental, and postcranial remains are mostly not associated. To proceed we applied the m... | ['Animals', 'Anthropometry', 'Fossils', 'Hominidae', 'Humans', 'Molar', 'Paleodontology', 'Principal Component Analysis', 'South Africa'] | 26,163,295 | [['B01.050'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['I01.076.368.584.311'], ['B01.050.150.900.649.313.988.400.112.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A14.549.167.860.525'], ['I01.076.368.584.583'], ['E05.318.740.562'], ['Z01.058.290.175.735']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Anatomy [A]', 'Geographicals [Z]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Impact of variation in ADRB2, ADRB3, and GNB3 genes on body mass index and waist circumference in a Brazilian population. | The potential effect of variants in three catecholaminergic pathway genes (ADRB2, ADRB3, and GNB3) on obesity-related traits was investigated in an European-derived Brazilian population. Three-hundred and thirty-five individuals were screened for the ADRB2 Arg16Gly and Gln27Glu, ADRB3 Trp64Arg, and GNB3 814G-->A and 82... | ['Adult', 'Body Constitution', 'Body Mass Index', 'Brazil', 'Female', 'GTP-Binding Proteins', 'Gene Frequency', 'Genetic Predisposition to Disease', 'Humans', 'Linkage Disequilibrium', 'Male', 'Obesity', 'Polymorphism, Genetic', 'Receptors, Adrenergic, beta-2', 'Receptors, Adrenergic, beta-3'] | 16,493,638 | [['M01.060.116'], ['E01.370.600.115', 'G07.100'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['Z01.107.757.176'], ['D08.811.277.040.330.300', 'D12.776.157.325'], ['G05.330'], ['C23.550.291.687.500', 'G05.380.355'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G05... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Geographicals [Z]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Sorting of the yeast vacuolar-type, proton-translocating ATPase enzyme complex (V-ATPase): identification of a necessary and sufficient Golgi/endosomal retention signal in Stv1p. | Subunit a of the yeast vacuolar-type, proton-translocating ATPase enzyme complex (V-ATPase) is responsible for both proton translocation and subcellular localization of this highly conserved molecular machine. Inclusion of the Vph1p isoform causes the V-ATPase complex to traffic to the vacuolar membrane, whereas incorp... | ['Amino Acid Motifs', 'Endosomes', 'Evolution, Molecular', 'Isoenzymes', 'Models, Molecular', 'Protein Sorting Signals', 'Protein Transport', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Structural Homology, Protein', 'Vacuolar Proton-Translocating ATPases', 'trans-Golgi Network'] | 22,496,448 | [['G02.111.570.820.709.275.500', 'G02.111.570.820.709.600.500'], ['A11.284.430.214.190.875.190.880.337'], ['G05.045.250', 'G16.075.250'], ['D08.811.348', 'D12.776.800.300'], ['E05.599.595'], ['D12.644.770', 'G02.111.570.060.670'], ['G03.143.700'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D12.776.354.750'],... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Maintaining forward view of the surgical site for best endoscopic practice. | Endoscopic surgery performed through patients' natural orifices (NOTES procedures) often require some degree of retroflexion of the operating system. This can cause a misalignment between the displayed image and the actual work plane, leading to performance difficulties. This study investigated the impact of retroflexi... | ['Endoscopy', 'Imaging, Three-Dimensional', 'Task Performance and Analysis', 'Telemedicine', 'User-Computer Interface', 'Visual Perception'] | 21,335,892 | [['E01.370.388.250', 'E04.502.250'], ['E01.370.350.400', 'L01.224.308.410'], ['F02.784.412.846', 'F02.784.692.746', 'F02.808.600'], ['H02.403.840', 'L01.178.847.652', 'N04.590.374.800'], ['L01.224.900.910'], ['F02.463.593.932']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Health Care [N]'] | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
IR820 covalently linked with self-assembled polypeptide for photothermal therapy applications in cancer. | Owing to the unique advantages of high specificity and minimal invasiveness, photothermal therapy (PTT) has been evidenced with great potential in cancer treatment. However, most photothermal agents present a shortage of photobleaching and nonspecific biodistribution in clinical application. In this study, we conjugate... | ['Amino Acid Sequence', 'Animals', 'Cell Line, Tumor', 'Cell Transformation, Neoplastic', 'Female', 'Humans', 'Hyperthermia, Induced', 'Indocyanine Green', 'Mice', 'Mice, Inbred BALB C', 'Nanoparticles', 'Peptides', 'Phototherapy', 'Temperature', 'Tissue Distribution'] | 30,229,774 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['C04.697.098.500', 'C23.550.727.098.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.565'], ['D03.633.100.473.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.9... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 |
Odd E. Hanssen and the Hanssen method for measurement of single-nephron glomerular filtration rate. | In the middle of the twentieth century, the suspicion that deep and superficial nephrons might serve different functions created a demand for measurement of single-nephron glomerular filtration rate (SNGFR). Rather unexpectedly, the answer came from Odd E. Hanssen (1917-1964), a Norwegian physician working on his own i... | ['Glomerular Filtration Rate', 'History, 20th Century', 'Humans', 'Kidney', 'Kidney Function Tests', 'Nephrons', 'Norway', 'Pathology', 'Physiology'] | 11,502,589 | [['E01.370.390.400.300', 'G08.852.357'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['E01.370.390.400'], ['A05.810.453.736'], ['Z01.542.816.374'], ['H02.403.650'], ['H01.158.782']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Humanities [K]', 'Organisms [B]', 'Anatomy [A]', 'Geographicals [Z]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 |
[The relationship between astronauts erroneous actions, their psychophysiological state and work and rest regimen]. | The correlation analysis of the data obtained in the MIR 18, and 21 through to 23 main missions was supportive of the strong dependence of erroneous actions by cosmonauts, their psychophysiologic state and the work/rest schedule. This conclusion guidelined the development of a prototype of technique to perform an integ... | ['Aerospace Medicine', 'Health Status', 'Humans', 'Mental Health', 'Rest', 'Safety', 'Space Flight', 'Work'] | 10,530,378 | [['H02.403.029'], ['I01.240.425', 'N01.224.425', 'N06.850.505.400.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.418', 'N01.400.500'], ['I03.450.769.647'], ['N06.850.135.060.075'], ['J01.937.285.850'], ['I03.946']] | ['Disciplines and Occupations [H]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Technology, Industry, and Agriculture [J]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 |
Micro-analytical GO/HRP bioreactor for glucose determination and bioprocess monitoring. | A bi-enzymatic micro-analytical bioreactor integrated in a FIA system for glucose measurements is described. Its robustness and small dimensions (working volume of about 70 microl containing approximately 1.2 mg GO and 0.26 mg HRP) make it easy to operate. The column is based on immobilisation of glucose oxidase (GO) a... | ['Animals', 'Bioreactors', 'Biosensing Techniques', 'Cell Culture Techniques', 'Cells, Cultured', 'Colorimetry', 'Equipment Design', 'Equipment Failure Analysis', 'Escherichia coli', 'Flow Injection Analysis', 'Glucose', 'Glucose Oxidase', 'Horseradish Peroxidase', 'Islets of Langerhans', 'Miniaturization', 'Pancreas, ... | 15,741,063 | [['B01.050'], ['E07.115', 'J01.897.120.115'], ['E05.601.043'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.251'], ['E05.196.922.250'], ['E05.320'], ['E05.325.192'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['E05.196.460'], ['D09.947.875.359.448'], ['D08.811.682.047... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Effects of Ischemic Preconditioning and Postconditioning in a Renal Ischemia-Reperfusion Injury Model: A Comparative Experimental Study in Rats. | BACKGROUND: Ischemia-reperfusion injury is an unavoidable aspect of transplantation, as well as an important cause of acute kidney injury in clinical practice. Pre- and post-ischemic conditioning are strategies that may provide organs with resistance to major ischemic events. This study evaluates the effects of ischemi... | ['Acute Kidney Injury', 'Animals', 'Ischemic Postconditioning', 'Ischemic Preconditioning', 'Male', 'Rats', 'Rats, Wistar', 'Reperfusion Injury'] | 30,501,900 | [['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['B01.050'], ['E02.587'], ['E02.592', 'E05.516'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.150.900.649.313.992.635.505.700.900'], ['C14.907.725', 'C23.550.767.877']] | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Genome-wide expression analysis reveals dysregulation of myelination-related genes in chronic schizophrenia. | Neuropathological and brain imaging studies suggest that schizophrenia may result from neurodevelopmental defects. Cytoarchitectural studies indicate cellular abnormalities suggestive of a disruption in neuronal connectivity in schizophrenia, particularly in the dorsolateral prefrontal cortex. Yet, the molecular mechan... | ['Chronic Disease', 'Gene Expression Profiling', 'Gene Expression Regulation', 'Genome, Human', 'Humans', 'Myelin Sheath', 'Schizophrenia'] | 11,296,301 | [['C23.550.291.500'], ['E05.393.332'], ['G05.308'], ['G05.360.340.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.637.600.500', 'A08.637.800.500', 'A08.675.542.512.560', 'A08.800.800.690.500', 'A10.755.503', 'A11.284.149.165.600', 'A11.650.600.500', 'A11.650.800.500', 'A11.671.501.512.560', 'A11.671.514.5... | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The effect of glycemic control in the pre-conception period and early pregnancy on birth weight in women with IDDM. | OBJECTIVE: To examine data from pregnancies in women with IDDM to assess the relative effects of mean glycosylated hemoglobin levels before conception, at booking, and during the 3 trimesters of pregnancy on birth weight. Good glycemic control during pregnancy in women with IDDM is important to minimize the risk of fet... | ['Adult', 'Age of Onset', 'Birth Weight', 'Blood Glucose', 'Diabetes Mellitus, Type 1', 'Female', 'Glycated Hemoglobin A', 'Humans', 'Infant, Newborn', 'Parity', 'Pregnancy', 'Pregnancy Outcome', 'Pregnancy in Diabetics', 'Retrospective Studies'] | 9,571,338 | [['M01.060.116'], ['N05.715.350.075.100', 'N06.850.490.250.100'], ['C23.888.144.186', 'E01.370.600.115.100.160.120.186', 'E05.041.124.160.750.149', 'G07.100.100.160.120.186', 'G07.345.249.314.120.186'], ['D09.947.875.359.448.500'], ['C18.452.394.750.124', 'C19.246.267', 'C20.111.327'], ['D09.400.430.937', 'D12.776.124.... | ['Named Groups [M]', 'Health Care [N]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Enhanced production of plumbagin in immobilized cells of Plumbago rosea by elicitation and in situ adsorption. | Cell cultures of Plumbago rosea were immobilized in calcium alginate and cultured in Murashige and Skoog's basal medium containing 10 mM CaCl(2) for the production of plumbagin, an important medicinal compound. Studies were carried to find out the impact of immobilization on the increased accumulation of this secondary... | ['Acrylic Resins', 'Adsorption', 'Alginates', 'Calcium Chloride', 'Cell Culture Techniques', 'Cells, Cultured', 'Cells, Immobilized', 'Chitin', 'Chitosan', 'Glucuronic Acid', 'Hexuronic Acids', 'Naphthoquinones', 'Plant Leaves', 'Plumbaginaceae', 'Polystyrenes', 'Sucrose'] | 12,568,747 | [['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['G01.030', 'G02.020'], ['D09.698.068'], ['D01.146.300', 'D01.210.450.150.150'], ['E01.370.225.500.223', 'E05.200.500.265', 'E05.242.223', 'E05.481.500.249'], ['A11.251'], ['A11.270'], ['D05.750.078.139', 'D09.698.211'], ['D05.750.078.139.5... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Early education of children with surgically treated cleft palate]. | Certain children operated upon for a cleft palate fail to achieve an intelligible organization of speech, making the educational role of the parents extremely difficult. These children must be detected as soon as possible for early treatment. Early training will emphasize the acquiring of bucco-phonatory praxis, velar ... | ['Cleft Palate', 'Humans', 'Infant', 'Language Therapy', 'Postoperative Period', 'Speech Therapy', 'Time Factors'] | 2,636,729 | [['C05.500.460.185', 'C05.660.207.540.460.185', 'C07.320.440.185', 'C07.465.525.185', 'C07.650.500.460.185', 'C07.650.525.185', 'C16.131.621.207.540.460.185', 'C16.131.850.500.460.185', 'C16.131.850.525.185'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['E02.760.169.063.500.727.344', 'E02.831.727... | ['Diseases [C]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Rad9/53BP1 protects stalled replication forks from degradation in Mec1/ATR-defective cells. | Nucleolytic processing by nucleases can be a relevant mechanism to allow repair/restart of stalled replication forks. However, nuclease action needs to be controlled to prevent overprocessing of damaged replication forks that can be detrimental to genome stability. The checkpoint protein Rad9/53BP1 is known to limit nu... | ['Cell Cycle Proteins', 'DNA Replication', 'Intracellular Signaling Peptides and Proteins', 'Microbial Viability', 'Protein-Serine-Threonine Kinases', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins', 'Stress, Physiological', 'Tumor Suppressor p53-Binding Protein 1'] | 29,301,856 | [['D12.776.167'], ['G02.111.225', 'G05.226'], ['D12.644.360', 'D12.776.476'], ['G06.580'], ['D08.811.913.696.620.682.700'], ['B01.300.107.795.785.800', 'B01.300.930.705.655'], ['D12.776.354.750'], ['G07.775'], ['D12.776.260.805', 'D12.776.660.235.850', 'D12.776.664.235.950']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Dot/Icm-Translocated Proteins Important for Biogenesis of the Coxiella burnetii-Containing Vacuole Identified by Screening of an Effector Mutant Sublibrary. | Coxiella burnetii is an intracellular pathogen that replicates in a lysosome-derived vacuole. A determinant necessary for C. burnetii virulence is the Dot/Icm type IVB secretion system (T4SS). The Dot/Icm system delivers more than 100 proteins, called type IV effectors (T4Es), across the vacuolar membrane into the host... | ['Autophagosomes', 'Bacterial Proteins', 'Bacterial Secretion Systems', 'Coxiella burnetii', 'DNA Transposable Elements', 'Epithelial Cells', 'Humans', 'Lysosomes', 'Macrophages', 'Mutation', 'Protein Transport', 'Q Fever', 'Vacuoles'] | 29,339,460 | [['A11.284.430.214.190.875.190.700.500'], ['D12.776.097'], ['D05.500.890.500'], ['B03.440.400.425.297.150.100', 'B03.660.250.132.150.100'], ['D13.444.308.520', 'G02.111.570.080.708.330.200', 'G05.360.080.708.330.200', 'G05.360.340.024.425.200'], ['A11.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.284.43... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Humoral responses in rabbits immunized with two fractions of Haemonchus contortus: the antigen specificity of such antibodies. | Humoral responses were examined in rabbits immunized with either 28-40 kDa (Fraction 1) or a 19-24 kDa (Fraction 2) antigenic fraction from soluble antigens (Sol L3 Ag) from infective larvae (L3) of Haemonchus contortus. These fractions were eluted from electrophoretically separated Sol L3 Ag. Immunoblots revealed anti... | ['Animals', 'Antibodies, Bacterial', 'Antibodies, Helminth', 'Antigens, Bacterial', 'Antigens, Helminth', 'Cross Reactions', 'Electrophoresis, Polyacrylamide Gel', 'Epitopes', 'Haemonchus', 'Immunization', 'Immunoblotting', 'Larva', 'Rabbits', 'Specific Pathogen-Free Organisms'] | 1,281,589 | [['B01.050'], ['D12.776.124.486.485.114.107', 'D12.776.124.790.651.114.125', 'D12.776.377.715.548.114.125'], ['D12.776.124.486.485.114.185', 'D12.776.124.790.651.114.185', 'D12.776.377.715.548.114.185'], ['D23.050.161'], ['D23.050.223'], ['G12.122.281'], ['E05.196.401.402', 'E05.301.300.319'], ['D23.050.550'], ['B01.05... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Global changes in the rat heart proteome induced by prolonged morphine treatment and withdrawal. | Morphine belongs among the most commonly used opioids in medical practice due to its strong analgesic effects. However, sustained administration of morphine leads to the development of tolerance and dependence and may cause long-lasting alterations in nervous tissue. Although proteomic approaches enabled to reveal chan... | ['Animals', 'Chaperonin 10', 'Chaperonin 60', 'Crystallins', 'HSP27 Heat-Shock Proteins', 'HSP70 Heat-Shock Proteins', 'Male', 'Morphine', 'Morphine Dependence', 'Myocardium', 'Proteome', 'Rats', 'Rats, Wistar', 'Substance Withdrawal Syndrome'] | 23,056,601 | [['B01.050'], ['D12.776.580.216.210.590.500'], ['D08.811.277.040.025.142.500.500', 'D12.776.580.216.210.590.750'], ['D12.776.306.366'], ['D12.776.580.216.270.625'], ['D12.776.580.216.375'], ['D03.132.577.249.562.571', 'D03.605.497.607.587', 'D03.633.400.686.607.587', 'D04.615.723.795.576.571'], ['C25.775.643.500.600', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Telmisartan protects against diabetic vascular complications in a mouse model of obesity and type 2 diabetes, partially through peroxisome proliferator activated receptor-ã-dependent activity. | Experimental and clinical data support the notion that peroxisome proliferator-activated receptor ã (PPARã) activation is associated with anti-atherosclerosis as well as anti-diabetic effect. Telmisartan, an angiotensin receptor blocker (ARB), acts as a partial PPARã agonist. We hypothesized that telmisartan protects a... | ['Angiotensin II Type 1 Receptor Blockers', 'Angiotensin-Converting Enzyme Inhibitors', 'Anilides', 'Animals', 'Benzimidazoles', 'Benzoates', 'Diabetes Mellitus, Type 2', 'Diabetic Angiopathies', 'Disease Models, Animal', 'Male', 'Mice', 'Mice, Inbred C57BL', 'Obesity', 'PPAR gamma', 'Telmisartan'] | 21,679,694 | [['D27.505.519.162.500'], ['D27.505.519.389.745.085'], ['D02.065.199', 'D02.092.146.113'], ['B01.050'], ['D03.633.100.103'], ['D02.241.223.100', 'D02.455.426.559.389.127'], ['C18.452.394.750.149', 'C19.246.300'], ['C14.907.320', 'C19.246.099.500'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['B01.050.150.900.649.31... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Antimicrobial Peptides, Polymorphic Toxins, and Self-Nonself Recognition Systems in Archaea: an Untapped Armory for Intermicrobial Conflicts. | Numerous, diverse, highly variable defense and offense genetic systems are encoded in most bacterial genomes and are involved in various forms of conflict among competing microbes or their eukaryotic hosts. Here we focus on the offense and self-versus-nonself discrimination systems encoded by archaeal genomes that so f... | ['Amino Acid Sequence', 'Antimicrobial Cationic Peptides', 'Archaea', 'Archaeal Proteins', 'Bacterial Proteins', 'Evolution, Molecular', 'Genome, Archaeal', 'Genome, Bacterial', 'Genomics', 'Microbial Interactions', 'Toxins, Biological'] | 31,064,832 | [['G02.111.570.060', 'L01.453.245.667.060'], ['D12.644.050', 'D12.776.543.695.054'], ['B02'], ['D12.776.090'], ['D12.776.097'], ['G05.045.250', 'G16.075.250'], ['G05.360.340.358.050'], ['G05.360.340.358.207'], ['H01.158.273.180.350', 'H01.158.273.343.350'], ['G06.550'], ['D23.946']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 |
Green tea extract and its polyphenols markedly inhibit luminol-dependent chemiluminescence activated by peroxynitrite or SIN-1. | This study is based on a simple chemical interaction of peroxynitrite (OONO-) and luminol, which produces blue light upon oxidation. Since peroxynitrite has a half-life of less than 1 s, a drug known as SIN-1 is used as a peroxynitrite generator. In addition peroxynitrite itself was used directly with a fast injection-... | ['Catechin', 'Flavonoids', 'Kinetics', 'Luminescent Measurements', 'Luminol', 'Molsidomine', 'Nitrates', 'Nitric Oxide Donors', 'Oxidants', 'Oxidation-Reduction', 'Phenols', 'Plant Extracts', 'Polymers', 'Tea'] | 10,660,664 | [['D03.383.663.283.240.190', 'D03.383.663.283.266.450.206', 'D03.633.100.150.240.190', 'D03.633.100.150.266.450.206'], ['D03.383.663.283.266.450', 'D03.633.100.150.266.450'], ['G01.374.661', 'G02.111.490'], ['E05.196.712.516'], ['D03.383.710.350'], ['D03.383.129.462.580.693.450', 'D03.383.533.640.362'], ['D01.248.497.1... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Leukotriene B4 signaling through NF-kappaB-dependent BLT1 receptors on vascular smooth muscle cells in atherosclerosis and intimal hyperplasia. | Leukotriene B(4) (LTB(4)), a potent leukocyte chemoattractant derived from the 5-lipoxygenase metabolism of arachidonic acid, exerts its action by means of specific cell surface receptors, denoted BLT(1) and BLT(2). In this study, BLT(1) receptor proteins were detected in human carotid artery atherosclerotic plaques, c... | ['Amidines', 'Analysis of Variance', 'Animals', 'Atherosclerosis', 'Blotting, Western', 'Carbamates', 'Carotid Artery Injuries', 'Cell Movement', 'Electrophysiology', 'Fatty Alcohols', 'Glycols', 'Humans', 'Hyperplasia', 'Leukotriene B4', 'Male', 'Muscle, Smooth, Vascular', 'NF-kappa B', 'Patch-Clamp Techniques', 'Poly... | 16,293,697 | [['D02.078'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['C14.907.137.126.307'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D02.241.081.251'], ['C10.228.140.300.200.345', 'C10.228.140.300.350.500', 'C10.900.250.300', 'C14.... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Disciplines and Occupations [H]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Yeast mitochondrial ADP/ATP carriers are monomeric in detergents. | Mitochondrial carriers are believed widely to be homodimers both in the inner membrane of the organelle and in detergents. The dimensions and molecular masses of the detergent and protein-detergent micelles were measured for yeast ADP/ATP carriers in a range of different detergents. The radius of the carrier at the mid... | ['Animals', 'Cattle', 'Chromatography, Gel', 'Detergents', 'Micelles', 'Mitochondrial ADP, ATP Translocases', 'Molecular Weight', 'Saccharomyces cerevisiae'] | 17,056,710 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['E05.196.181.400.250'], ['D27.720.877.265', 'J01.516.381'], ['D05.374', 'D26.255.560'], ['D12.776.157.530.625.875.500', 'D12.776.157.530.937.594', 'D12.776.543.585.450.162.225', 'D12.776.543.585.475.500', 'D12.776.543.585.625.875.500', 'D12.776.543.585.937.688', '... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Study on sepsis in the elderly at Nagoyashi-Koseiin Geriatric Hospital]. | A study based on clinical analysis was conducted regarding the 125 episodes in the elderly 112 patients of sepsis who were 70 (average 83.8 +/- 7.5) years old at Nagoyashi-Koseiin Geriatric Hospital from 1985 through 1994. 1) The backgrounds of the elderly patients with sepsis were as follows: bedridden (72.8%), urinar... | ['Aged', 'Aged, 80 and over', 'Disseminated Intravascular Coagulation', 'Escherichia coli', 'Female', 'Hospitals, Municipal', 'Humans', 'Male', 'Methicillin Resistance', 'Multiple Organ Failure', 'Prognosis', 'Sepsis', 'Staphylococcus aureus'] | 7,499,917 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C15.378.100.220', 'C15.378.463.250', 'C15.378.925.220'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['N02.278.421.510.210', 'N02.278.421.660.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G06.099.225.500.600.525', 'G06.225.347.500.600.525', 'G07.6... | ['Named Groups [M]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Conformational changes in concanavalin A associated with demetallization and alpha-methylmannose binding studied by Fourier transform infrared spectroscopy. | Infrared spectra of concanavalin A have been obtained both in the absence and in the presence of the metal ions, Mn2+ and Ca2+, and the saccharide, alpha-methylmannose. Second derivative calculations have been used to determine the frequencies of the different amide I and II components. In the demetallized protein diss... | ['Calcium', 'Concanavalin A', 'Fourier Analysis', 'Manganese', 'Methylglycosides', 'Methylmannosides', 'Protein Conformation', 'Spectrophotometry, Infrared', 'X-Ray Diffraction'] | 3,663,684 | [['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['D12.776.503.499.500', 'D12.776.765.678.500'], ['E05.377', 'G17.226', 'L01.224.800.625'], ['D01.268.556.484', 'D01.268.956.374', 'D01.552.544.484'], ['D09.408.514'], ['D09.408.490.500', 'D09.408.514.700'], ['G02.111.570.820.709'], ['E05.196.712.726.676', 'E05.196... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Incorporating immunological ideas in epidemiological models. | Many diseases show important interactions between epidemiology and immunology. Both models and data suggest that epidemiologically controlled variables, like frequency and intensity of exposure, can affect immunological outcomes in a wide variety of diseases. Conversely, the results of the immunological "battle" betwee... | ['Epidemiology', 'Humans', 'Models, Immunological', 'Models, Statistical', 'Parasitic Diseases', 'Prevalence'] | 8,759,527 | [['H02.403.720.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.395.500'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['C01.610'], ['E05.318.308.985.525.750', 'N01.224.935.597.750', 'N06.850.505.400.975.525.750', 'N06.850.520.308.985.525.750']] | ['Disciplines and Occupations [H]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Life-threatening Arrhythmias in a Becker Muscular Dystrophy Family due to the Duplication of Exons 3-4 of the Dystrophin Gene. | We herein present a report of three patients with Becker muscular dystrophy in the same family who developed complete atrioventricular block or ventricular tachycardia with severe cardiomyopathy. Our cases became unable to walk in their teens, and were introduced to mechanical ventilation due to respiratory muscle weak... | ['Adolescent', 'Arrhythmias, Cardiac', 'Cardiomyopathies', 'Dystrophin', 'Exons', 'Gene Deletion', 'Humans', 'Male', 'Middle Aged', 'Muscular Dystrophy, Duchenne', 'Pacemaker, Artificial', 'Tachycardia, Ventricular'] | 26,631,896 | [['M01.060.057'], ['C14.280.067', 'C23.550.073'], ['C14.280.238'], ['D12.776.210.500.250', 'D12.776.220.250', 'D12.776.543.250'], ['G05.360.340.024.340.137.232'], ['G05.365.590.762.320', 'G05.558.800.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['C05.651.534.500.300', 'C10.668.491.175.50... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Relationship between skin temperature and muscle activation during incremental cycle exercise. | While different studies showed that better fitness level adds to the efficiency of the thermoregulatory system, the relationship between muscular effort and skin temperature is still unknown. Therefore, the present study assessed the relationship between neuromuscular activation and skin temperature during cycle exerci... | ['Adult', 'Body Temperature Regulation', 'Electromyography', 'Exercise', 'Humans', 'Muscle, Skeletal', 'Skin Temperature', 'Thermography', 'Young Adult'] | 25,660,627 | [['M01.060.116'], ['G07.110.232', 'G07.410.421', 'G16.012.500.535'], ['E01.370.405.255', 'E01.370.530.255'], ['G11.427.410.698.277', 'I03.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.633.567', 'A10.690.552.500'], ['G07.110.753', 'G13.750.844'], ['E01.370.350.800', 'E05.933.500'], ['M01.060.116.815']] | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
Prognostic factors in gastric cancer: the value of vascular invasion, mitotic rate and lymphoplasmacytic infiltration. | A retrospective analysis of 321 gastric cancer patients was made to assess the prognostic value of TNM classification, tumour differentiation, Laur?n classification, proliferative rate, inflammatory reaction and tumour invasion in vascular or neural structures of the gastric wall. The TNM classification showed the stro... | ['Adult', 'Aged', 'Aged, 80 and over', 'Cell Division', 'Female', 'Follow-Up Studies', 'Gastrectomy', 'Humans', 'Lymphatic Metastasis', 'Lymphocytes, Tumor-Infiltrating', 'Male', 'Middle Aged', 'Multivariate Analysis', 'Neoplasm Invasiveness', 'Neoplasm Staging', 'Plasma Cells', 'Prognosis', 'Retrospective Studies', 'S... | 8,795,580 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['E04.210.419'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.697.650.560', 'C23.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Burn-out, commitment, personality and experiences during work and training; survey among psychiatry residents]. | BACKGROUND: In the last few years international studies have reported on increase in burn-out and depressive symptoms among psychiatry residents. In the field of research, however, commitment and dedication are now being mentioned more frequently as positive factors that counterbalance burn-out.AIM: To find out how a g... | ['Burnout, Professional', 'Depression', 'Education, Medical, Graduate', 'Female', 'Humans', 'Internship and Residency', 'Job Satisfaction', 'Male', 'Personal Satisfaction', 'Personality', 'Psychiatry'] | 28,350,150 | [['C24.580.500', 'F01.145.126.990.367.500', 'F02.830.900.333.500'], ['F01.145.126.350'], ['I02.358.337.350', 'I02.358.399.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['F02.784.692.425'], ['F01.145.677'], ['F01.752'], ['F04.096.544', 'H02.403.690']] | ['Diseases [C]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 |
Melatonin Ameliorates Busulfan-Induced Spermatogonial Stem Cell Oxidative Apoptosis in Mouse Testes. | AIMS: Many men endure immunosuppressive or anticancer treatments that contain alkylating agents before the age of sexual maturity, especially the increasing number of preadolescent males who undergo busulfan treatment for myeloablative conditioning before hematopoietic stem cell transplantation. Before sperm production... | ['Animals', 'Apoptosis', 'Busulfan', 'Gene Expression Regulation, Developmental', 'Humans', 'Male', 'Melatonin', 'Mice', 'Oxidative Stress', 'Reactive Oxygen Species', 'Sirtuin 1', 'Spermatogonia', 'Stem Cells', 'Superoxide Dismutase', 'Testis', 'Tumor Suppressor Protein p53', 'Ubiquitin'] | 28,027,652 | [['B01.050'], ['G04.146.954.035'], ['D02.033.455.125.125', 'D02.455.326.146.100.050.500.100', 'D02.886.645.600.055.050.510.100'], ['G05.308.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D03.633.100.473.914.481', 'D06.472.506'], ['B01.050.150.900.649.313.992.635.505.500'], ['G03.673', 'G07.775.750'], ['D01.3... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Cerebrospinal fluid from human immunodeficiency virus--infected individuals facilitates neurotoxicity by suppressing intracellular calcium recovery. | Neurologic decline associated with penetration of human immunodeficiency virus type 1(HIV-1) into the central nervous system is thought to be due, in large part, to inflammation and local secretion of neurotoxic substances. To examine the cellular processes that mediate neurotoxicity in vivo, the authors valuated the a... | ['Adult', 'Animals', 'Animals, Newborn', 'Astrocytes', 'Calcium', 'Cells, Cultured', 'Glutamic Acid', 'HIV Infections', 'Humans', 'Microglia', 'Neurons', 'Neurotoxins', 'Rats', 'Rats, Long-Evans'] | 16,036,793 | [['M01.060.116'], ['B01.050'], ['B01.050.050.282'], ['A08.637.200', 'A11.650.200'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251'], ['D12.125.067.625.349', 'D12.125.119.409.349', 'D12.125.427.300'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Characterization of cytoskeleton mechanical properties and 3D-actin structure in twisted adherent epithelial cells. | Evaluation of the cytoskeleton mechanical properties requires specific micromanipulation techniques such as the magnetic twisting cytometry technique, in which microbeads are specifically linked to the cytoskeleton via transmembrane receptors. The aim of the study was to assess the structural relationship between the b... | ['Actins', 'Cell Adhesion', 'Cytoskeleton', 'Epithelial Cells', 'Feasibility Studies', 'Humans', 'Image Processing, Computer-Assisted', 'Magnetics', 'Micromanipulation', 'Microscopy, Confocal', 'Microspheres'] | 12,454,411 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['G04.022'], ['A11.284.430.214.190.750'], ['A11.436'], ['E05.318.372.550', 'E05.337.675', 'N05.715.360.330.550', 'N06.850.520.450.550'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['H01.671.493'], ['E05.591'], ['E01.370.350.5... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Change in meal size, number and duration after neural isolation of liver and with TPN. | The abundant neural connections between the liver and hypothalamus suggest that the liver contributes to spontaneous food intake (SFI) regulation. This hypothesis was tested in rats after total liver denervation (TLD) and infusing TPN. A sham operation (SO) or TLD was performed in Fischer rats, placed in metabolic cage... | ['Animals', 'Body Weight', 'Catheterization', 'Denervation', 'Diet', 'Feeding Behavior', 'Jugular Veins', 'Liver', 'Male', 'Parenteral Nutrition, Total', 'Rats', 'Rats, Inbred F344'] | 1,801,017 | [['B01.050'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['E02.148', 'E05.157'], ['E04.525.210'], ['G07.203.650.240'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['A07.015.908.498'], ['A03.620'], ['E02.421.505.575', 'E02.642.500.505.7... | ['Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Underutilization of aspirin for primary prevention of cardiovascular disease among HIV-infected patients. | BACKGROUND: Individuals infected with human immunodeficiency virus (HIV) are at increased risk for cardiovascular disease (CVD) events compared with uninfected persons. However, little is known about HIV provider practices regarding aspirin (ASA) for primary prevention of CVD.METHODS: A cross-sectional study was conduc... | ['Aged', 'Aspirin', 'Cross-Sectional Studies', 'Drug Utilization', 'Female', 'HIV Infections', 'Heart Diseases', 'Humans', 'Male', 'Middle Aged', 'Odds Ratio', 'Risk Factors'] | 22,942,209 | [['M01.060.116.100'], ['D02.455.426.559.389.657.410.595.176'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['N04.452.706.477'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['C14.280'], ['B01.050.150.900.64... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Amelioration of delayed-type hypersensitivity responses by IL-27 administration. | Interleukin (IL-) 27 is a member of the IL-12 cytokine family. Although recent analyses of WSX-1 (IL-27 receptor alpha chain)-deficient mice as well as in vitro studies using recombinant IL-27 revealed the immunosuppressive function of IL-27, in vivo role and therapeutic potential of IL-27 remain poorly elucidated. Her... | ['Animals', 'CD4-Positive T-Lymphocytes', 'Dermatitis, Allergic Contact', 'Disease Models, Animal', 'Immunosuppression', 'Interleukin-10', 'Interleukin-17', 'Mice', 'Mice, Mutant Strains', 'Mutation', 'Receptors, Cytokine', 'Receptors, Interleukin', 'Recombinant Proteins'] | 18,572,017 | [['B01.050'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['C17.800.174.255.100', 'C17.800.815.255.100', 'C20.543.418.150'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['E02.095.465.425.450', 'E05.478.610'], ['D12.644.276.374.465.510', 'D12.776.467.374.465.510'... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
rBet v 1 immunotherapy of sensitized mice with Streptococcus thermophilus as vehicle and adjuvant. | Lactobacilli are able to induce upregulation of co-stimulatory molecules in DCs with Th1 cytokines production and increase in Treg activity. This could explain the observed effectiveness of the prolonged administration of lactobacilli in the prevention of allergic disorders in infants and envisage the possible use of b... | ['Adjuvants, Immunologic', 'Allergens', 'Animals', 'Antigens, Plant', 'Cells, Cultured', 'Drug Delivery Systems', 'Humans', 'Immunotherapy', 'Mice', 'Mice, Inbred BALB C', 'Streptococcus thermophilus'] | 24,603,094 | [['D27.505.696.477.067'], ['D23.050.063'], ['B01.050'], ['D23.050.291'], ['A11.251'], ['E02.319.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.095.465.425'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['B03.353.750.737.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Application of fluoride iontophoresis to improve remineralization. | Iontophoresis is generally used to maximize the therapeutic action of drugs in medicine. This technique can be used to improve the remineralization effect of topical fluoride applications in dentistry. The aim of this study was to compare the remineralization effect of fluoride iontophoresis (FI) with the conventional ... | ['Animals', 'Cattle', 'Dental Enamel', 'Fluorides', 'Hardness', 'Iontophoresis', 'Surface Properties', 'Tooth Remineralization'] | 19,758,412 | [['B01.050'], ['B01.050.150.900.649.313.500.380.271'], ['A14.549.167.900.255'], ['D01.248.497.158.380', 'D01.303.350.300'], ['G01.374.647'], ['E02.319.267.650', 'E05.301.300.575'], ['G02.860'], ['E06.950']] | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Evaluation of on-line pyrolysis coupled to isotope ratio mass spectrometry for the determination of position-specific (13)C isotope composition of short chain n-alkanes (C6-C12). | We measured (13)C intramolecular isotopic composition of commercially available short-chain hydrocarbons (n-C6-n-C12) using (13)C-NMR. Results show that the main variation is between the terminal and the sub-terminal C-atom positions. Site-preference (difference in ä(13)C values between terminal and sub-terminal C-atom... | ['Alkanes', 'Carbon Isotopes', 'Mass Spectrometry', 'Methane'] | 27,130,103 | [['D02.455.326.146'], ['D01.268.150.075', 'D01.496.123'], ['E05.196.566'], ['D02.455.326.146.571']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Food-dependent, exercise-induced anaphylaxis in a patient allergic to peach. | Determining the single factor that triggered anaphylactic shock can be challenging. We present an interesting case of a 25-year-old female patient with recurrent anaphylactic reactions developing after eating various foods, particularly in presence of co-factors of allergic reactions. Symptoms occurred after consumptio... | ['Adult', 'Anaphylaxis', 'Antigens, Plant', 'Carrier Proteins', 'Exercise', 'Exercise Test', 'Female', 'Food Hypersensitivity', 'Fruit', 'Humans', 'Immunoglobulin E', 'Intracellular Signaling Peptides and Proteins', 'Intradermal Tests', 'Juglans', 'Nuts', 'Plant Proteins', 'Pollen', 'Prunus persica', 'Recurrence', 'Ris... | 30,270,687 | [['M01.060.116'], ['C20.543.480.099'], ['D23.050.291'], ['D12.776.157'], ['G11.427.410.698.277', 'I03.350'], ['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['C20.543.480.370'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.6... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Organisms [B]', 'Health Care... | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Risk of tumor progression in colon carcinoma resection and perioperative prophylaxis with polyvalent immunoglobulins - per aspera ad astra. | There is strong evidence that tumor progression in the postoperative period is attributable to the influx of lipopolysaccharides (LPS) into the blood from the gastrointestinal (GI) lumen. Although several research groups have emphasized the need to neutralize LPS antigens from the GI tract to prevent tumor progression ... | ['Administration, Oral', 'Colectomy', 'Colonic Neoplasms', 'Disease Progression', 'Drug Administration Schedule', 'Gastrointestinal Microbiome', 'Humans', 'Immunoglobulins', 'Inflammation', 'Lipopolysaccharides', 'Protective Factors', 'Risk Assessment', 'Risk Factors', 'Treatment Outcome'] | 29,319,494 | [['E02.319.267.100'], ['E04.210.219'], ['C04.588.274.476.411.307.180', 'C06.301.371.411.307.180', 'C06.405.249.411.307.180', 'C06.405.469.158.356.180', 'C06.405.469.491.307.180'], ['C23.550.291.656'], ['E02.319.283'], ['G06.591.375', 'G16.500.275.157.049.100.500.375', 'N06.230.124.049.100.500.250'], ['B01.050.150.900.6... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
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