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FAT-FREE MASS, METABOLICALLY HEALTHY OBESITY, AND TYPE 2 DIABETES IN SEVERELY OBESE ASIAN ADULTS. | OBJECTIVE: To determine whether fat free mass (FFM) is independently associated with the metabolically healthy obesity (MHO) phenotype, the metabolic syndrome (MS), and type 2 diabetes (T2D) in obese Asian adults.METHODS: Obese patients (body mass index [BMI] ?25 kg/m2) seeking weight management at an academic medical ... | ['Absorptiometry, Photon', 'Adipose Tissue', 'Adult', 'Asian Continental Ancestry Group', 'Body Composition', 'Body Mass Index', 'Diabetes Mellitus, Type 2', 'Electric Impedance', 'Female', 'Glycated Hemoglobin A', 'Humans', 'Male', 'Metabolic Syndrome', 'Middle Aged', 'Multivariate Analysis', 'Muscle, Skeletal', 'Obes... | 28,614,006 | [['E01.370.350.700.024', 'E05.196.712.224.187'], ['A10.165.114'], ['M01.060.116'], ['M01.686.508.200'], ['G02.111.130', 'G03.180', 'G07.100.049'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['C18.452.394.750.149', 'C19.246.300'], ['G01.358.500.249.277.350'], ['D09.400.... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Whole-genome array-CGH screening in undiagnosed syndromic patients: old syndromes revisited and new alterations. | We report array-CGH screening of 95 syndromic patients with normal G-banded karyotypes and at least one of the following features: mental retardation, heart defects, deafness, obesity, craniofacial dysmorphisms or urogenital tract malformations. Chromosome imbalances not previously detected in normal controls were foun... | ['Adolescent', 'Child', 'Child, Preschool', 'Chromosome Banding', 'Female', 'Gene Deletion', 'Genetic Diseases, Inborn', 'Genome, Human', 'Humans', 'Infant', 'Male', 'Mutation', 'Nucleic Acid Hybridization', 'Polymorphism, Genetic', 'Syndrome'] | 17,124,408 | [['M01.060.057'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.225.500.385.130', 'E01.370.225.500.620.670.130', 'E01.370.225.750.600.670.130', 'E05.200.500.385.130', 'E05.200.500.620.670.130', 'E05.200.750.600.670.130', 'E05.242.385.130', 'E05.393.285.130'], ['G05.365.590.762.320', 'G05.558.800.320'], ['C16.320'], [... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Left cardiac sympathetic denervation as the first-line therapy for congenital long QT syndrome. | Congenital long QT syndrome (LQTS) is a cardiac electrophysiological disorder due to genetic mutations. Patients with LQTS, if untreated, have a high incidence of ventricular tachycardia and cardiac arrest. Adrenergic activities are believed to play a major role in triggering the onset of cardiac events. The current ma... | ['Cardiac Surgical Procedures', 'Clinical Trials as Topic', 'Evidence-Based Medicine', 'Heart', 'Humans', 'Long QT Syndrome', 'Microsurgery', 'Sympathectomy', 'Thoracic Surgery, Video-Assisted', 'Treatment Outcome'] | 15,288,363 | [['E04.100.376', 'E04.928.220'], ['E05.318.372.250.250', 'N05.715.360.330.250.250', 'N06.850.520.450.250.250'], ['H02.249.750', 'H02.403.200.400'], ['A07.541'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C14.280.067.565', 'C14.280.123.625', 'C16.131.240.400.715', 'C23.550.073.547'], ['E04.494', 'E05.591.580'], ... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
[Participation of the hypothalamus in conditioning and emotional behavior. (1) Behavior model in rabbits and methods of its analysis]. | An attempt was made to induce conflict behavior in rabbits by conditioning under hypothalamic electrical stimulation. Behavioral analysis was performed using our newly devised technique which employs the use of a vibration apparatus fixed to head and waist, and a recording of various behavior. Conditioning was carried ... | ['Animals', 'Conditioning, Classical', 'Electric Stimulation', 'Fear', 'Habituation, Psychophysiologic', 'Hypothalamus', 'Male', 'Methods', 'Models, Psychological', 'Physical Stimulation', 'Rabbits', 'Reinforcement, Psychology', 'Respiration'] | 987,969 | [['B01.050'], ['F02.463.425.179.308'], ['E05.723.402'], ['F01.470.361'], ['F02.463.425.393', 'F02.830.422', 'G11.561.312'], ['A08.186.211.180.497', 'A08.186.211.200.317.357'], ['E05.581'], ['E05.599.695'], ['E05.723'], ['B01.050.150.900.649.313.968.700'], ['F02.463.425.770'], ['G09.772.705']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Effect of clarithromycin in patients with suspected Gram-negative sepsis: results of a randomized controlled trial. | BACKGROUND: A previous randomized study showed that clarithromycin decreases the risk of death due to ventilator-associated pneumonia and shortens the time until infection resolution. The efficacy of clarithromycin was tested in a larger population with sepsis.METHODS: Six hundred patients with systemic inflammatory re... | ['Administration, Intravenous', 'Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Anti-Bacterial Agents', 'Clarithromycin', 'Double-Blind Method', 'Female', 'Gram-Negative Bacterial Infections', 'Health Care Costs', 'Humans', 'Male', 'Middle Aged', 'Placebos', 'Prospective Studies', 'Sepsis', 'Survival Analysis', 'T... | 24,292,991 | [['E02.319.267.082'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.122.085'], ['D02.540.576.500.992.100'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['C01.150.252.400'], ['N03.219.151.400', 'N05.300.375'], ['B01.050.150.900.649... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Ophthalmology human resource projections: are we heading for a crisis in the next 15 years? | BACKGROUND: Ophthalmology residency positions have increased in recent years. This study looks at whether the expansion is enough to avoid shortages in the future.METHODS: The Canadian Medical Association Physician Resource Evaluation Template was used to project the supply of ophthalmologists up to 2016, assuming a st... | ['Canada', 'Education, Medical, Graduate', 'Health Resources', 'Health Services Needs and Demand', 'Health Services Research', 'Health Workforce', 'Humans', 'Internship and Residency', 'Ophthalmology', 'Population Growth', 'Waiting Lists'] | 17,361,238 | [['Z01.107.567.176'], ['I02.358.337.350', 'I02.358.399.350'], ['N03.349.340', 'N05.300.420'], ['N03.349.380.420', 'N05.300.450'], ['H01.770.644.145.360', 'N03.349.380', 'N05.425'], ['N02.350', 'N04.452.525.500', 'N05.300.420.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['I02.358.337.350.500', 'I02.358.399.35... | ['Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 |
Timing of oviductal fluid collection, steroid concentrations, and sperm preservation method affect porcine in vitro fertilization efficiency. | OBJECTIVE: To determine optimal conditions for the inclusion of oviductal fluid (OF) in IVF protocols.DESIGN: Experimental prospective study.SETTING: Mammalian reproduction research laboratory.ANIMAL(S): Oviducts and ovaries from porcine females were collected at a slaughterhouse. A total of 30 oviducts and 1,285 oocyt... | ['Animals', 'Body Fluids', 'Estradiol', 'Fallopian Tubes', 'Female', 'Fertilization in Vitro', 'Freezing', 'Male', 'Progesterone', 'Prospective Studies', 'Spermatozoa', 'Swine', 'Time Factors'] | 25,241,366 | [['B01.050'], ['A12.207'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['A05.360.319.114.373', 'A13.706.500'], ['E02.875.800.750', 'E05.820.800.750'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['D04.210.500.745.745.654.829', 'D06.472.334.734.623', 'D06.472.334.851.687.750'], ['E05.318.372.500.7... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
The role of Raf kinase inhibitor protein in rheumatoid fibroblast-like synoviocytes invasiveness and cytokine and matrix metalloproteinase expression. | Fibroblast-like synoviocytes (FLS) play an important role in the pathogenesis of rheumatoid arthritis. Raf kinase inhibitor protein (RKIP) negatively regulates the Raf/MEK/ERK and NF-êB pathway. The role of RKIP in rheumatoid FLS is unknown. The purpose of the present study was to investigate the function of RKIP in rh... | ['Arthritis, Rheumatoid', 'Cells, Cultured', 'Extracellular Signal-Regulated MAP Kinases', 'Humans', 'Interleukin-6', 'Interleukin-8', 'MAP Kinase Kinase Kinases', 'Matrix Metalloproteinase 1', 'Matrix Metalloproteinase 3', 'NF-kappa B', 'Phosphatidylethanolamine Binding Protein', 'RNA Interference', 'RNA, Messenger', ... | 21,556,737 | [['C05.550.114.154', 'C05.799.114', 'C17.300.775.099', 'C20.111.199'], ['A11.251'], ['D08.811.913.696.620.682.700.567.249', 'D12.644.360.450.169', 'D12.776.476.450.169'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.644.276.374.465.224', 'D12.776.467.374.465.202', 'D23.529.374.465.224'], ['D12.644.276.374.200... | ['Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Role of tannin-binding salivary proteins and tannase-producing bacteria in the acclimation of the Japanese wood mouse to acorn tannins. | We studied the defense mechanisms against the negative effects of tannins in acorns by using the Japanese wood mouse (Apodemus speciosus) and acorns of a Japanese deciduous oak Quercus crispula, which contain 9.9% tannins on a dry weight basis. For the experiment, we allocated 26 wood mice into two groups: acclimated (... | ['Adaptation, Physiological', 'Animals', 'Bacterial Physiological Phenomena', 'Body Weight', 'Carboxylic Ester Hydrolases', 'Digestion', 'Female', 'Male', 'Mice', 'Murinae', 'Quercus', 'Salivary Proteins and Peptides', 'Seeds', 'Survival Rate', 'Tannins'] | 16,770,711 | [['G07.025', 'G16.012.500'], ['B01.050'], ['G06.099'], ['C23.888.144', 'E01.370.600.115.100.160.120', 'E05.041.124.160.750', 'G07.100.100.160.120', 'G07.345.249.314.120'], ['D08.811.277.352.100'], ['G07.203.650.250', 'G10.261.190'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.150.900.649.313.992.635.505'], [... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Correction of factor XI deficiency by liver transplantation. | Orthotopic liver transplantation for other diseases typically results in a coincidental cure for hemophilia A and B; however, long-term outcomes of liver transplant in hemophilia C are not very well described. Herein, the authors report a patient of severe congenital factor XI (FXI) deficiency who received an orthotopi... | ['Disease Management', 'Factor XI', 'Factor XI Deficiency', 'Humans', 'Liver', 'Liver Transplantation', 'Male', 'Middle Aged', 'Transplantation, Homologous', 'Treatment Outcome'] | 26,196,192 | [['N04.590.607'], ['D08.622.490', 'D12.776.124.125.425', 'D12.776.811.243.490', 'D23.119.425'], ['C15.378.100.100.325', 'C15.378.100.141.325', 'C15.378.463.325', 'C16.320.099.325'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A03.620'], ['E02.095.147.725.490', 'E04.210.650', 'E04.936.450.490', 'E04.936.580.490']... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Magnetic properties of tunicate blood cells. II. Ascidia ceratodes. | The magnetic properties of intact blood cells of the tunicate Ascidia ceratodes have been measured up to 50 kOe with a SQUID susceptometer. Analysis of total metal contents by plasma emission spectroscopy and V(IV) content by epr indicates that approximately 5% of the accumulated vanadium is +4 vanadyl ion. Measured va... | ['Animals', 'Blood Cells', 'Electron Spin Resonance Spectroscopy', 'Magnetics', 'Models, Chemical', 'Temperature', 'Urochordata', 'Vanadium'] | 8,758,882 | [['B01.050'], ['A11.118', 'A15.145.229'], ['E05.196.867.519.274'], ['H01.671.493'], ['E05.599.495'], ['G01.906.595', 'G16.500.275.063.725.710', 'G16.500.750.775.710', 'N06.230.150.450', 'N06.230.300.100.725.710'], ['B01.050.150.200.727', 'B01.050.500.272.727'], ['D01.268.556.920', 'D01.268.956.886', 'D01.552.544.920']] | ['Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Magnet field profiling: analysis and correcting coil design. | A full mathematical framework for the analysis and production of localized magnetic field profiles is presented. Of primary use in the production of highly homogeneous fields for nuclear magnetic resonance studies, the paper details the analysis of fields in terms of spherical harmonics, describes how field plotting in... | ['Humans', 'Magnetic Resonance Spectroscopy', 'Mathematics'] | 6,571,436 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.196.867.519'], ['H01.548']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A primary care, multi-disciplinary disease management program for opioid-treated patients with chronic non-cancer pain and a high burden of psychiatric comorbidity. | BACKGROUND: Chronic non-cancer pain is a common problem that is often accompanied by psychiatric comorbidity and disability. The effectiveness of a multi-disciplinary pain management program was tested in a 3 month before and after trial.METHODS: Providers in an academic general medicine clinic referred patients with c... | ['Adult', 'Aged', 'Analgesics, Opioid', 'Chronic Disease', 'Cohort Studies', 'Comorbidity', 'Depression', 'Diagnosis, Dual (Psychiatry)', 'Disease Management', 'Drug Utilization', 'Family Practice', 'Female', 'Humans', 'Male', 'Middle Aged', 'Pain', 'Pain Measurement', 'Primary Health Care', 'Program Evaluation', 'Psyc... | 15,649,331 | [['M01.060.116'], ['M01.060.116.100'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['C23.550.291.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N05.715.350.225', 'N06.850.490.687'], ['F01.145.126.3... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 |
Multiple neuromuscular abnormalities in a paranoid schizophrenic. | A broad range of skeletal muscle fiber abnormalities has been reported previously in muscle biopsy specimens from psychotic patients. In our experience, individual patients manifest only a few types of lesions; but we now have studied a paranoid schizophrenic patient whose skeletal muscle fibers show virtually the enti... | ['Adult', 'Enzymes', 'Histocytochemistry', 'Humans', 'Male', 'Motor Neurons', 'Muscles', 'Neurologic Examination', 'Neuromuscular Diseases', 'Schizophrenia, Paranoid'] | 6,934,557 | [['M01.060.116'], ['D08.811'], ['E01.370.225.500.607', 'E01.370.225.750.551', 'E05.200.500.607', 'E05.200.750.551', 'H01.158.100.656.234', 'H01.158.201.344', 'H01.181.122.573'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.675.655.500', 'A11.671.655.500'], ['A02.633', 'A10.690'], ['E01.370.376.550', 'E01.370.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 |
A 3-year naturalistic study of 53 preschool children with pervasive developmental disorders treated with risperidone. | BACKGROUND: Only sparse and short-term data are available on pharmacologic treatments in very young children with pervasive developmental disorders (PDD). The purpose of this 3-year naturalistic study (March 1999-April 2002) is to describe the clinical outcome of a consecutive sample of preschool children with PDD trea... | ['Antipsychotic Agents', 'Autistic Disorder', 'Child', 'Child Development Disorders, Pervasive', 'Child, Preschool', 'Dose-Response Relationship, Drug', 'Female', 'Follow-Up Studies', 'Humans', 'Long-Term Care', 'Male', 'Personality Assessment', 'Prolactin', 'Prospective Studies', 'Psychiatric Status Rating Scales', 'R... | 14,628,979 | [['D27.505.696.277.950.040', 'D27.505.954.427.210.950.040', 'D27.505.954.427.700.872.331'], ['F03.625.164.113.500'], ['M01.060.406'], ['F03.625.164'], ['M01.060.406.448'], ['G07.690.773.875', 'G07.690.936.500'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150.900... | ['Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Repetitive Episodic Isolated Vertigo in a Patient with Cerebellar Infarction. | Isolated vertigo is an important symptom of posterior circulation stroke. It has been reported that 11.3% of patients with isolated vertigo have a stroke and that most lesions are located in the cerebellum, particularly in the posterior inferior cerebellar artery. We report the case of a 63-year-old man with multiple a... | ['Anticoagulants', 'Brain Infarction', 'Cerebellar Diseases', 'Cerebral Angiography', 'Computed Tomography Angiography', 'Humans', 'Male', 'Middle Aged', 'Postural Balance', 'Posture', 'Recurrence', 'Secondary Prevention', 'Treatment Outcome', 'Vertigo', 'Warfarin'] | 31,010,764 | [['D27.505.954.502.119'], ['C10.228.140.300.150.477', 'C10.228.140.300.775.200', 'C14.907.253.092.477', 'C14.907.253.855.200', 'C23.550.513.355.250', 'C23.550.717.489.250'], ['C10.228.140.252'], ['E01.370.350.578.937.180', 'E01.370.350.700.060.180', 'E01.370.350.700.560.180', 'E01.370.370.050.180', 'E01.370.376.537.750... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Inflammatory cytokines drive CD4+ T-cell cycling and impaired responsiveness to interleukin 7: implications for immune failure in HIV disease. | BACKGROUND: Systemic inflammation has been linked to a failure to normalize CD4(+) T-cell numbers in treated human immunodeficiency virus (HIV) infection. Although inflammatory cytokines such as interleukin 6 (IL-6) are predictors of disease progression in treated HIV infection, it is not clear how or whether inflammat... | ['Antiretroviral Therapy, Highly Active', 'CD4-Positive T-Lymphocytes', 'Cell Cycle', 'Cells, Cultured', 'HIV Infections', 'HIV-1', 'Humans', 'Inflammation', 'Interleukin-1beta', 'Interleukin-6', 'Interleukin-7', 'Interleukin-7 Receptor alpha Subunit', 'Leukocytes, Mononuclear', 'Receptors, Interleukin-7'] | 24,585,897 | [['E02.319.310.075'], ['A11.118.637.555.567.569.200', 'A15.145.229.637.555.567.569.200', 'A15.382.490.555.567.569.200'], ['G04.144'], ['A11.251'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['B04.820.650.589.650.350.400'], ['B01.050.150.90... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Double-blind comparison of fluoxetine and nortriptyline in the treatment of moderate to severe major depression. | BACKGROUND: Depression is an international public health problem. Impairment in social and occupational functioning, increased comorbidity with other psychiatric and medical conditions, and an increased risk of mortality are a few of its consequences. Some psychiatrists have the impression that selective serotonin re-u... | ['Adult', 'Antidepressive Agents, Second-Generation', 'Antidepressive Agents, Tricyclic', 'Depressive Disorder', 'Double-Blind Method', 'Female', 'Fluoxetine', 'Humans', 'Male', 'Middle Aged', 'Nortriptyline'] | 14,632,962 | [['M01.060.116'], ['D27.505.954.427.700.122.050'], ['D27.505.954.427.700.122.055'], ['F03.600.300'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['D02.092.831.280'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['D02.455.426.559.847.181.384.535', 'D04.6... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Neuronal ablation of mt-AspRS in mice induces immune pathway activation prior to severe and progressive cortical and behavioral disruption. | Leukoencephalopathy with brainstem and spinal cord involvement and lactate elevation (LBSL) is a rare, slowly progressive white matter disease caused by mutations in the mitochondrial aspartyl-tRNA synthetase (mt-AspRS, or DARS2). While patients show characteristic MRI T2 signal abnormalities throughout the cerebral wh... | ['Animals', 'Aspartate-tRNA Ligase', 'Atrophy', 'Behavior, Animal', 'Brain', 'Calcium-Calmodulin-Dependent Protein Kinase Type 2', 'Cerebral Cortex', 'Corpus Callosum', 'Hippocampus', 'Leukoencephalopathies', 'Magnetic Resonance Imaging', 'Mice', 'Mice, Knockout', 'Mitochondria', 'Neurons'] | 31,887,305 | [['B01.050'], ['D08.811.464.263.200.150'], ['C23.300.070'], ['F01.145.113'], ['A08.186.211'], ['D08.811.913.696.620.682.700.125.200', 'D12.644.360.100.200', 'D12.776.476.100.200'], ['A08.186.211.200.885.287.500'], ['A08.186.211.200.885.800.750'], ['A08.186.211.180.405', 'A08.186.211.200.885.287.500.345'], ['C10.228.140... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Early care and education for children in immigrant families. | A substantial and growing share of the population, immigrant children are more likely than children with native-born parents to face a variety of circumstances, such as low family income, low parental education, and language barriers that place them at risk of developmental delay and poor academic performance once they... | ['Child Care', 'Child, Preschool', 'Early Intervention, Educational', 'Emigrants and Immigrants', 'Humans', 'Infant', 'Infant, Newborn'] | 21,465,856 | [['I01.880.787.293.360', 'N02.421.088'], ['M01.060.406.448'], ['N02.421.143.130.320', 'N02.421.726.320'], ['M01.189'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520']] | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
Architecture and density of the connective tissue papillae of the human oral mucosa. | The papillary body of the human oral mucosa was studied at six different sites. Biopsy and autopsy material from 57 individuals, 11-81 years of age, was split chemically along the basal lamina and the epithelium-connective tissue interface examined by light and scanning electron microscopy. Morphometric techniques were... | ['Adolescent', 'Adult', 'Aged', 'Alveolar Process', 'Anthropometry', 'Cheek', 'Child', 'Connective Tissue', 'Epithelial Cells', 'Epithelium', 'Female', 'Gingiva', 'Humans', 'Lip', 'Male', 'Microscopy, Electron, Scanning', 'Middle Aged', 'Mouth Floor', 'Mouth Mucosa', 'Palate'] | 838,625 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['A02.835.232.781.324.502.125', 'A14.521.125', 'A14.549.167.646.094'], ['E01.370.600.024', 'E05.041', 'N06.850.505.200.100'], ['A01.456.505.173', 'A14.194'], ['M01.060.406'], ['A10.165'], ['A11.436'], ['A10.272'], ['A14.549.167.646.480'], ['B01.050.150.900.649.313... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Photosensitizer-conjugated Cu-In-S heterostructured nanorods for cancer targeted photothermal/photodynamic synergistic therapy. | Photo-activated therapy is a non-invasive and promising medical technology for the treatment of cancers. Herein, we present Ce6-HA-CIS phototherapeutic nanohybrids composed of Cu-In-S (CIS) heterostructured nanorod (HS-rod), chlorin e6 (Ce6), and hyaluronic acid (HA) for the use in targeted photodynamic/photothermal th... | ['Animals', 'Biocompatible Materials', 'Cell Line, Tumor', 'Cell Survival', 'Copper', 'Embryo, Nonmammalian', 'Female', 'Hyaluronic Acid', 'Indium', 'Light', 'Male', 'Melanoma, Experimental', 'Mice', 'Nanotubes', 'Photochemotherapy', 'Photosensitizing Agents', 'Porphyrins', 'Singlet Oxygen', 'Sulfur', 'Zebrafish'] | 30,678,970 | [['B01.050'], ['D25.130', 'D27.720.102.130', 'J01.637.051.130'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['D01.268.556.195', 'D01.268.956.170', 'D01.552.544.195'], ['A13.350', 'A16.331'], ['D09.698.373.475'], ['D01.268.556.381', 'D01.552.544.381'], ['G01.358.500.505.650', 'G01.590.540', 'G01.750.250.650', ... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
A hierarchical spectral clustering and nonlinear dimensionality reduction scheme for detection of prostate cancer from magnetic resonance spectroscopy (MRS). | Magnetic resonance spectroscopy (MRS) has been shown to have great clinical potential as a supplement to magnetic resonance imaging in the detection of prostate cancer (CaP). MRS provides functional information in the form of changes in the relative concentration of specific metabolites including choline, creatine, and... | ['Algorithms', 'Cluster Analysis', 'Diagnosis, Computer-Assisted', 'Humans', 'Linear Models', 'Magnetic Resonance Spectroscopy', 'Male', 'Nonlinear Dynamics', 'Pilot Projects', 'Probability', 'Prostate', 'Prostatic Neoplasms', 'Reproducibility of Results', 'Sensitivity and Specificity', 'Signal Processing, Computer-Ass... | 19,810,465 | [['G17.035', 'L01.224.050'], ['E05.318.740.250', 'N05.715.360.750.200', 'N06.850.520.830.250'], ['E01.158', 'L01.313.500.750.100.158'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.740.500.500', 'E05.318.740.750.425', 'E05.599.835.750', 'N05.715.360.750.530.460', 'N05.715.360.750.695.460', 'N06.850.520.83... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
Real and virtual mobility performance in simulated prosthetic vision. | Wayfinding is an important activity that can be performed with limited visual resources, and thus may be an important application of early visual prostheses. In a pair of experiments we explored minimal visual resolution requirements of a simulated retinal electrode array for mobility in real and virtual environments, ... | ['Adult', 'Blindness', 'Environment', 'Female', 'Humans', 'Image Interpretation, Computer-Assisted', 'Locomotion', 'Male', 'Movement', 'Prostheses and Implants', 'Psychomotor Performance', 'Space Perception', 'User-Computer Interface'] | 17,325,421 | [['M01.060.116'], ['C10.597.751.941.162', 'C11.966.075', 'C23.888.592.763.941.162'], ['G16.500.275', 'N06.230'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.158.600', 'E01.370.350.350', 'L01.313.500.750.100.158.600'], ['G07.568.500', 'G11.427.410.568'], ['G07.568', 'G11.427.410'], ['E07.695'], ['F02.808', 'G... | ['Named Groups [M]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Correlation between oocyte number and follicular fluid concentration of pituitary adenylate cyclase-activating polypeptide (PACAP) in women after superovulation treatment. | Follicular growth, ovulation, and luteinization are influenced by interactions of peptide and steroid hormone-signaling cascades in the ovary. Pituitary adenylate cyclase-activating polypeptide (PACAP) plays an important role in the regulation of several endocrine processes and is present in ovarian follicular fluid (F... | ['Adult', 'Biomarkers', 'Cell Count', 'Chorionic Gonadotropin', 'Female', 'Follicle Stimulating Hormone, Human', 'Follicular Fluid', 'Humans', 'Infertility, Female', 'Oocytes', 'Ovarian Hyperstimulation Syndrome', 'Ovary', 'Pilot Projects', 'Pituitary Adenylate Cyclase-Activating Polypeptide', 'Recombinant Proteins', '... | 22,415,357 | [['M01.060.116'], ['D23.101'], ['E01.370.225.500.195', 'E05.200.500.195', 'E05.242.195', 'G04.140'], ['D06.472.699.322.326', 'D06.472.699.649.367', 'D12.644.548.726.367', 'D12.776.780.400'], ['D06.472.699.631.525.343.288.625'], ['A05.360.319.114.630.535.150', 'A06.300.312.497.535.150', 'A12.207.270.340'], ['B01.050.150... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Head-Mounted Mixed-Reality Technology During Robotic-Assisted Transanal Total Mesorectal Excision. | INTRODUCTION: Head-mounted mixed-reality technologies may enable advanced intraoperative visualization during visceral surgery. In this technical note, we describe an innovative use of real-time mixed reality during robotic-assisted transanal total mesorectal excision.TECHNIQUE: Video signals from the robotic console a... | ['Adenocarcinoma', 'Aged', 'Humans', 'Male', 'Mesentery', 'Proctectomy', 'Rectal Neoplasms', 'Robotic Surgical Procedures', 'Transanal Endoscopic Surgery', 'Virtual Reality'] | 30,640,838 | [['C04.557.470.200.025'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.923.047.025.600.451'], ['E04.210.895'], ['C04.588.274.476.411.307.790', 'C06.301.371.411.307.790', 'C06.405.249.411.307.790', 'C06.405.469.491.307.790', 'C06.405.469.860.180.500'], ['E04.749.500', 'J01.897.104.834.500'... | ['Diseases [C]', 'Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 0 | 0 |
High-performance liquid chromatographic separation and identification of epimeric 17-ketone impurities in commercial sample of dexamethasone sodium phosphate. | A commercial sample of dexamethasone sodium phosphate solution for injection was found to contain 56% of the label concentration and to be extensively contaminated (approximately 50%) with a white insoluble solid, which was identified as a mixture of the 16 alpha- and 16 beta-methyl epimers of 9-fluoro-11 beta-hydroxy-... | ['Chromatography, High Pressure Liquid', 'Chromatography, Thin Layer', 'Dexamethasone', 'Drug Contamination', 'Isomerism', 'Ketones', 'Methods'] | 435,334 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Identification of a sequence within the mouse metallothionein-I gene promoter mediating its basal transcription and of a protein interacting with this element. | Previous studies in our laboratory have shown that a trans-acting factor, which binds to a 106 bp sequence in the mouse metallothionein-I (MT-I) gene, is responsible for the relatively high level of MT-I gene transcription in the liver. Using electrophoretic mobility shift assay, we have now identified a 26 bp sequence... | ['Animals', 'Base Sequence', 'Cell Nucleus', 'Cross-Linking Reagents', 'HeLa Cells', 'Humans', 'Metallothionein', 'Methylation', 'Mice', 'Molecular Sequence Data', 'Molecular Weight', 'Oligonucleotide Probes', 'Promoter Regions, Genetic', 'Protein Binding', 'Subcellular Fractions', 'Trans-Activators', 'Transcription, G... | 8,173,589 | [['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['D27.720.470.410.210'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.556.670'], ['G02.111.035.538', 'G02.607.094.538'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Undetectable bcr-abl rearrangements in some CML patients are due to a deletion mutation in the bcr gene. | Most patients with chronic myelogenous leukemia (CML) have Philadelphia (Ph) chromosome. Breakpoints on chromosome 22 in CML occur in a small region designated as the breakpoint cluster region (bcr). More than 90 percent of CML patients have breakpoints in the bcr; the remaining patients had no detectable rearrangement... | ['Chromosome Aberrations', 'Chromosome Deletion', 'Chromosome Disorders', 'Chromosomes, Human, Pair 22', 'Cloning, Molecular', 'DNA Restriction Enzymes', 'Humans', 'Leukemia, Myeloid', 'Mutation', 'Nucleotide Mapping', 'Oncogenes', 'Recombination, Genetic'] | 2,835,901 | [['C23.550.210', 'G05.365.590.175'], ['C23.550.210.050.500.500', 'G05.365.590.029.530.175', 'G05.365.590.175.050.500.500', 'G05.365.590.762.180', 'G05.558.800.180', 'G05.700.131.500.500'], ['C16.131.260', 'C16.320.180'], ['A11.284.187.520.300.505.515', 'G05.360.162.520.300.505.515'], ['E05.393.220'], ['D08.811.150.280'... | ['Diseases [C]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The analgesic effect of crossing the arms. | The ability to determine precisely the location of sensory stimuli is fundamental to how we interact with the world; indeed, to our survival. Crossing the hands over the body midline impairs this ability to localize tactile stimuli. We hypothesized that crossing the arms would modulate the intensity of pain evoked by n... | ['Adult', 'Analgesia', 'Biophysics', 'Electric Stimulation', 'Electromyography', 'Evoked Potentials, Somatosensory', 'Female', 'Functional Laterality', 'Hand', 'Humans', 'Lasers', 'Male', 'Pain', 'Pain Management', 'Pain Measurement', 'Physical Stimulation', 'Young Adult'] | 21,440,992 | [['M01.060.116'], ['E03.091'], ['H01.158.344', 'H01.671.100'], ['E05.723.402'], ['E01.370.405.255', 'E01.370.530.255'], ['G07.265.216.500.400', 'G11.561.200.500.400'], ['F02.830.297.425', 'G11.561.225.425'], ['A01.378.800.667'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.632.490', 'E07.710.520'], ['C23.888.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Oxygen partial pressure plays a crucial role in B16 melanoma cell survival by regulating autophagy and mitochondrial functions. | The oxygen partial pressure generally increases when cancerous cells become part of the blood vessels. The study was to investigate the influence of oxygen partial pressure on the apoptosis of B16 melanoma cells. Our results demonstrated that both short-term and long-term hypoxia/reoxygenation (H/R) treatment increased... | ['Animals', 'Autophagy', 'Cell Line, Tumor', 'Cell Survival', 'Melanoma, Experimental', 'Mice', 'Mitochondria', 'Oxygen', 'Partial Pressure', 'Reactive Oxygen Species', 'Tumor Hypoxia'] | 30,745,108 | [['B01.050'], ['G04.011'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.346'], ['C04.557.465.625.650.510.525', 'C04.557.580.625.650.510.525', 'C04.557.665.510.525', 'C04.619.600', 'E05.598.500.496.937'], ['B01.050.150.900.649.313.992.635.505.500'], ['A11.284.430.214.190.875.564', 'A11.284.835.626'], ['D01.268.185.550'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Myoglobin immunoassay utilizing directional surface plasmon-coupled emission. | We described an immunoassay for the cardiac marker myoglobin on a thin silver mirror surface using surface plasmon-coupled emission (SPCE). SPCE occurs for fluorophores in proximity (within approximately 200 nm) of a thin metal film (in our case, silver) and results in a highly directional radiation through a glass sub... | ['Immunoassay', 'Myoglobin', 'Sensitivity and Specificity', 'Spectrometry, Fluorescence', 'Surface Plasmon Resonance'] | 15,516,120 | [['E05.478.566', 'E05.601.470'], ['D12.776.210.500.588', 'D12.776.422.316.940'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.715.360.325.700', 'N05.715.360.750.725', 'N06.850.520.445.800', 'N06.850.520.830.872'], ['E05.196.712.516.600.676', 'E05.196.867.726'], ['E05.196.890', 'E05.601.043.700']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Mast cells containing melanin granules in sublingual keratosis. | In an ultrastructural study of 3 biopsies taken from the floor of the mouth of 2 patients suffering from sublingual keratosis, it was found that some of the mast cells appearing within the epithelium and connective tissue contained melanin granules which were found to be positive with Masson Fontana stain for melanin. ... | ['Adult', 'Aged', 'Cytoplasmic Granules', 'Female', 'Humans', 'Leukoplakia, Oral', 'Male', 'Mast Cells', 'Melanins', 'Mouth Floor', 'Phagocytosis'] | 3,114,448 | [['M01.060.116'], ['M01.060.116.100'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.443.591.545', 'C04.834.512.513', 'C07.465.530.545', 'C23.300.816.513'], ['A11.329.427', 'A15.382.652'], ['D12.125.072.050.875.379', 'D23.767.620'], ['A14.549.... | ['Named Groups [M]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Relationship between intrafollicular concentrations of parathyroid hormone-related peptide (PTHrP) and steroid hormones in oestrogenic and non-oestrogenic ovarian follicles in the mare. | The objective of the present study was to determine whether parathyroid hormone-related peptide (PTHrP) is present in the equine follicular fluid and if so, how it is related to the follicular development in the horse. For this purpose, ovaries were collected from 40 Thoroughbred and Thoroughbred Cross mares at slaught... | ['Animals', 'Estradiol', 'Female', 'Follicular Fluid', 'Horses', 'Ovarian Follicle', 'Parathyroid Hormone-Related Protein', 'Peptide Hormones', 'Progesterone', 'Testosterone'] | 12,559,723 | [['B01.050'], ['D04.210.500.365.415.248', 'D06.472.334.851.437.500'], ['A05.360.319.114.630.535.150', 'A06.300.312.497.535.150', 'A12.207.270.340'], ['B01.050.150.900.649.313.984.235.472'], ['A05.360.319.114.630.535', 'A06.300.312.497.535'], ['D06.472.699.591', 'D12.644.276.908', 'D12.644.548.588', 'D12.776.467.890', '... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of Marine Submergence and Season on Faunal Colonization and Decomposition of Pig Carcasses in the Salish Sea. | Pig carcasses, as human proxies, were placed on the seabed at a depth of 300 m, in the Strait of Georgia and observed continuously by a remotely operated camera and instruments. Two carcasses were deployed in spring and two in fall utilizing Ocean Network Canada's Victoria Experimental Network under the Sea (formerly V... | ['Amphipoda', 'Animals', 'British Columbia', 'Feeding Behavior', 'Oceans and Seas', 'Oxygen', 'Postmortem Changes', 'Seasons', 'Seawater', 'Sus scrofa', 'Washington'] | 26,930,206 | [['B01.050.500.131.365.055'], ['B01.050'], ['Z01.107.567.176.160'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['G01.311.625', 'G16.500.275.725.500.650', 'Z01.756'], ['D01.268.185.550', 'D01.362.670'], ['C23.550.260.224.617'], ['G01.910.645.661', 'G16.500.275.071.590', 'N06.230.300.100.250.525'], ['G16.500.... | ['Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 |
2-photon imaging of phagocyte-mediated T cell activation in the CNS. | Autoreactive T cells can infiltrate the CNS to cause disorders such as multiple sclerosis. In order to visualize T cell activation in the CNS, we introduced a truncated fluorescent derivative of nuclear factor of activated T cells (NFAT) as a real-time T cell activation indicator. In experimental autoimmune encephalomy... | ['Animals', 'Antigen-Presenting Cells', 'Autoantigens', 'Blood-Brain Barrier', 'Cell Communication', 'Cell Movement', 'Cell Nucleus', 'Cell Tracking', 'Cells, Cultured', 'Encephalomyelitis, Autoimmune, Experimental', 'Green Fluorescent Proteins', 'Kinetics', 'Lymphocyte Activation', 'Male', 'Meninges', 'Microscopy, Con... | 23,454,769 | [['B01.050'], ['A11.066', 'A15.382.066'], ['D23.050.422'], ['A07.035', 'A08.186.211.035'], ['G04.085'], ['G04.198', 'G07.568.500.180'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['E01.370.225.500.373', 'E01.370.350.557.500', 'E05.200.500.373', 'E05.242.373'], ['A11.251'], ['C10.114.703.300', 'C10.228.140.695.... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Technology, Industry, and Agriculture [J]', 'Information Science [L]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Past, present and future challenges in health care priority setting. | Purpose Current conditions have intensified the need for health systems to engage in the difficult task of priority setting. As the search for a "magic bullet" is replaced by an appreciation for the interplay between evidence, interests, culture, and outcomes, progress in relation to these dimensions requires assessmen... | ['Cross-Sectional Studies', 'Decision Making', 'Health Policy', 'Health Priorities', 'Hospital Administration', 'Surveys and Questionnaires'] | 29,771,204 | [['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['F02.463.785.373'], ['I01.655.500.608.400', 'I01.880.604.825.608.400', 'N03.623.500.608.428'], ['N03.349.330', 'N05.300.400'], ['H02.309', 'N02.278.216.500', 'N04.452.442.452'], ['E05.318.308.980', 'N05.715.360.300.800', 'N06.850.520.308.9... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Disciplines and Occupations [H]'] | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
Analysis of bacterial flora associated with peri-implantitis using obligate anaerobic culture technique and 16S rDNA gene sequence. | PURPOSE: To analyze and characterize the predominant bacterial flora associated with peri-implantitis by using culture techniques under obligate anaerobic conditions and 16S rDNA gene sequences.MATERIALS AND METHODS: Subgingival bacterial specimens were taken from 30 patients: control (n = 15), consisting of patients w... | ['Aged', 'Bacteria', 'Bacteria, Anaerobic', 'Bacterial Load', 'Bacteriological Techniques', 'Case-Control Studies', 'DNA, Ribosomal', 'Dental Implants', 'Female', 'Gingiva', 'Humans', 'Male', 'Middle Aged', 'Peri-Implantitis', 'Polymerase Chain Reaction', 'Sequence Analysis, DNA'] | 24,278,920 | [['M01.060.116.100'], ['B03'], ['B03.130'], ['E01.370.225.875.150.115', 'E01.370.225.875.220.115', 'E05.200.875.150.115', 'E05.200.875.220.115', 'G06.099.100'], ['E01.370.225.875.150', 'E05.200.875.150'], ['E05.318.372.500.500', 'N05.715.360.330.500.500', 'N06.850.520.450.500.500'], ['D13.444.308.475'], ['D25.339.312',... | ['Named Groups [M]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 |
[Distribution of 14C-nicotinic acid in the organs of white rats with a prolonged protein and choline deficit]. | In animals receiving for 12 months a ration deficiency of protein and choline distribution of 14C-nicotinic acid among their organs was determined. In the distribution 14C-nicotinic acid in the organs of the control and test groups of the animals no difference was in evidence. | ['Animals', 'Carbon Radioisotopes', 'Choline Deficiency', 'Liver', 'Male', 'Nicotinic Acids', 'Protein Deficiency', 'Rats', 'Time Factors'] | 1,021,991 | [['B01.050'], ['D01.268.150.075.328', 'D01.496.123.328', 'D01.496.749.154'], ['C18.654.521.500.133.699.160'], ['A03.620'], ['D03.066.515', 'D03.383.725.547'], ['C18.654.521.500.708'], ['B01.050.150.900.649.313.992.635.505.700'], ['G01.910.857']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Renovascular disease and the risk of adverse coronary events in the elderly: a prospective, population-based study. | BACKGROUND: Renovascular disease is a cause of secondary hypertension and renal insufficiency and is suspected to contribute to morbidity and mortality of coronary heart disease. This investigation prospectively examined associations between renovascular disease and adverse coronary events among a population-based samp... | ['Age Distribution', 'Aged', 'Aged, 80 and over', 'Analysis of Variance', 'Cohort Studies', 'Comorbidity', 'Coronary Disease', 'Female', 'Geriatric Assessment', 'Heart Function Tests', 'Humans', 'Hypertension, Renovascular', 'Incidence', 'Kidney Function Tests', 'Male', 'Multivariate Analysis', 'Probability', 'Prognosi... | 15,668,368 | [['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['N05.715.350.225', 'N06.850.490.687'], ['C14.280.647.250', 'C14.907.585... | ['Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Circumaortic renal collar. A potentially hazardous anomaly of the left renal vein. | The circumaortic renal collar is a potentially hazardous anomaly of the left renal vein. Failure to recognize the dorsal component during retroperitoneal surgery may lead to hemorrhage, nephrectomy or death. The angiographer can make a significant contribution in documenting this anomally in patients who are candidates... | ['Female', 'Humans', 'Male', 'Middle Aged', 'Radiography', 'Renal Veins'] | 1,200,228 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.350.700'], ['A07.015.908.752']] | ['Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Occupational Health and Safety in the smelting and foundry industries in Mexico. | This paper reviews the epidemiological features of the accidents and illnesses in smelters and foundries affiliated with Instituto Mexicano del Seguro Social for the year 1977. The accident rate per 100 workers was 26, which was second to mining among all industries listed; this rate is almost double that for all facto... | ['Accidents, Occupational', 'Humans', 'Legislation as Topic', 'Metallurgy', 'Mexico', 'Occupational Diseases', 'Occupational Medicine', 'Safety'] | 7,342,770 | [['N06.850.135.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.706.615'], ['J01.576.655.875.400'], ['Z01.107.567.589'], ['C24'], ['H02.403.720.750.510'], ['N06.850.135.060.075']] | ['Health Care [N]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Geographicals [Z]', 'Diseases [C]', 'Disciplines and Occupations [H]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 |
Inhibition of regulatory volume decrease in swollen rat primary astrocyte cultures by methylmercury is due to increased amiloride-sensitive Na+ uptake. | Primary astrocyte cultures from neonatal rats were swollen by exposure to hypotonic buffer with and without 10 microM methylmercury (MeHg). We investigated the effects of MeHg on K+ (using 86Rb), taurine, D-aspartate (a non metabolizable analogue of glutamate) and Na+ fluxes during regulatory volume decrease (RVD), wit... | ['Amiloride', 'Analysis of Variance', 'Animals', 'Animals, Newborn', 'Aspartic Acid', 'Astrocytes', 'Biological Transport', 'Cells, Cultured', 'Cerebral Cortex', 'Homeostasis', 'Hypotonic Solutions', 'Kinetics', 'Methylmercury Compounds', 'Potassium', 'Rats', 'Rats, Sprague-Dawley', 'Rubidium', 'Sodium', 'Taurine'] | 8,891,281 | [['D03.383.679.149'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['B01.050.050.282'], ['D12.125.067.500', 'D12.125.119.170', 'D12.125.427.040'], ['A08.637.200', 'A11.650.200'], ['G03.143'], ['A11.251'], ['A08.186.211.200.885.287.500'], ['G07.410'], ['D26.776.399'], ['G01.374.661', '... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Hepatocyte nuclear factor 4á transactivates the mitochondrial alanine aminotransferase gene in the kidney of Sparus aurata. | Alanine aminotransferase (ALT) plays an important role in amino acid metabolism and gluconeogenesis. The preference of carnivorous fish for protein amino acids instead of carbohydrates as a source of energy lead us to study the transcriptional regulation of the mitochondrial ALT (mALT) gene and to characterize the enzy... | ['Alanine Transaminase', 'Amino Acid Sequence', 'Animals', 'Base Sequence', 'Cell Line', 'Cloning, Molecular', 'DNA, Complementary', 'Gene Expression Regulation, Enzymologic', 'Hepatocyte Nuclear Factor 4', 'Intracellular Signaling Peptides and Proteins', 'Kidney', 'Mitochondria', 'Molecular Sequence Data', 'Phylogeny'... | 21,607,544 | [['D08.811.913.477.700.100'], ['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['A11.251.210'], ['E05.393.220'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G05.308.320'], ['D12.776.260.262.968', 'D12.776.660.352.968... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Reversible reduction of insulin receptor affinity by ATP depletion in rat adipocytes. | The effects of the metabolic inhibitor NaN3 on insulin receptors in isolated rat fat-cells were investigated. The agent reduced insulin binding in parallel to a decrease of the ATP content of cells. Both effects were observed in the same concentration range of NaN3, and were fully reversible. According to the binding c... | ['Adenosine Triphosphate', 'Adipose Tissue', 'Animals', 'In Vitro Techniques', 'Insulin', 'Kinetics', 'Male', 'Rats', 'Rats, Inbred Strains', 'Receptor, Insulin', 'Sodium Nitrite'] | 6,351,848 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['A10.165.114'], ['B01.050'], ['E05.481'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['G01.374.661', 'G02.111.490'], ['B01.050.150.900.649.313.992.635.505.700'], ['B01.050.050.199.520.760', 'B01.050.150.900.649.313.992... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impairment of RNA synthesis and its recovery in angelicin photosensitized mammalian cells. A probe for DNA damage and repair. | The template activity of DNA for ribosomal RNA transcription has been investigated in monkey kidney CV-1 cells after angelicin photosensitization in order to monitor the induction of lesions in the DNA and their possible subsequent disappearance, i.e. repair. Separate confluent cultures were submitted to a single angel... | ['Cell Line', 'DNA', 'DNA Repair', 'Dose-Response Relationship, Radiation', 'Furocoumarins', 'Kinetics', 'RNA', 'Ribosomes', 'Templates, Genetic', 'Transcription, Genetic', 'Ultraviolet Rays'] | 718,926 | [['A11.251.210'], ['D13.444.308'], ['G02.111.222', 'G05.219'], ['E05.799.513.500', 'G01.750.740.500', 'G04.712.500', 'G07.225', 'G07.738.500', 'N06.850.810.250.180'], ['D03.383.663.283.446.794', 'D03.633.100.150.446.794', 'D03.633.300.770'], ['G01.374.661', 'G02.111.490'], ['D13.444.735'], ['A11.284.430.214.190.875.811... | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Arterial foam cells with distinctive immunomorphologic and histochemical features of macrophages. | A variable population of fat-filled "foam" cells in diet-induced experimental arterial intimal plaques of rabbits and monkeys were analyzed for several features characteristic of macrophages. These included: 1) surface binding and phagocytosis of antibody-coated or complement-coated erythrocytes to detect specific surf... | ['Animals', 'Aorta', 'Arteriosclerosis', 'Carotid Arteries', 'Erythrocytes', 'Femoral Artery', 'Foam Cells', 'Haplorhini', 'Immunoglobulin G', 'Lipase', 'Macrophages', 'Male', 'Muramidase', 'Muscle, Smooth', 'Phagocytosis', 'Rabbits', 'Receptors, Complement', 'Receptors, Fc', 'Receptors, Immunologic', 'Rosette Formatio... | 6,772,035 | [['B01.050'], ['A07.015.114.056'], ['C14.907.137.126'], ['A07.015.114.186'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['A07.015.114.351'], ['A11.329.372.368', 'A11.627.482.368', 'A11.733.397.368', 'A15.382.670.522.368', 'A15.382.680.397.368'], ['B01.050.150.900.649.313.988.400'], ['D12.776.124.486.485.114.619... | ['Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Human maternal and fetal response to graded exercise. | Six healthy active women in the third trimester of pregnancy participated in a graded exercise protocol to levels of exertion perceived to be equivalent to that of their usual exercise regimen. Fetal heart rate response (FHR) was documented by ultrasound transducer and confirmed (n = 1) by ultrasonic visualization. Res... | ['Exercise Test', 'Female', 'Fetal Heart', 'Fetal Monitoring', 'Fetal Movement', 'Heart Rate', 'Hematocrit', 'Humans', 'Lactates', 'Lactic Acid', 'Leukocyte Count', 'Maternal-Fetal Exchange', 'Oxygen Consumption', 'Physical Exertion', 'Pregnancy', 'Ultrasonography'] | 3,888,949 | [['E01.370.370.380.250', 'E01.370.386.700.250', 'E05.333.250'], ['A07.541.278', 'A16.378.303'], ['E01.370.378.230', 'E01.370.520.230'], ['G07.345.500.325.235.374', 'G08.686.784.170.157.374'], ['E01.370.600.875.500', 'G09.330.380.500'], ['E01.370.225.625.400', 'E05.200.625.400', 'G09.188.370.374'], ['B01.050.150.900.649... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Impact of naturally forming human á/â-tryptase heterotetramers in the pathogenesis of hereditary á-tryptasemia. | Both á-tryptase and â-tryptase are preferentially expressed by human mast cells, but the purpose of á-tryptase is enigmatic, because its tetramers lack protease activity, whereas â-tryptase tetramers are active proteases. The monogenic disorder called hereditary á-tryptasemia, due to increased á-tryptase gene copies an... | ['Adult', 'Allosteric Regulation', 'Cell Degranulation', 'Female', 'Genetic Diseases, Inborn', 'Humans', 'Male', 'Mast Cells', 'Protein Multimerization', 'Receptor, PAR-2', 'Receptors, G-Protein-Coupled', 'Tryptases', 'Vibration'] | 31,337,736 | [['M01.060.116'], ['G02.111.044'], ['G04.468.160'], ['C16.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A11.329.427', 'A15.382.652'], ['G02.111.694'], ['D12.776.543.750.695.035', 'D12.776.543.750.792.249'], ['D12.776.543.750.695'], ['D08.811.277.656.300.760.902', 'D08.811.277.656.959.350.902'], ['G01.374.93... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Complete remission of previously intractable peripheral cutaneous T-cell lymphoma of the lower extremity using isolated hyperthermic limb perfusion with melphalan (1-phenylalanine mustard). | The patient is a 74-year-old woman first diagnosed with a peripheral cutaneous T-cell lymphoma (PCTCL) in April of 1994. Initially she presented with subcutaneous indurated areas in the right forearm, scapula, and submadibular region. After chemotherapy with CHOP (cyclophosphamide, doxorubicin, vincristine, and prednis... | ['Aged', 'Amputation', 'Antineoplastic Agents, Alkylating', 'Chemotherapy, Cancer, Regional Perfusion', 'Combined Modality Therapy', 'Female', 'Humans', 'Hyperthermia, Induced', 'Lower Extremity', 'Lymphoma, T-Cell, Cutaneous', 'Melphalan', 'Neoplasm Metastasis', 'Neoplasm Recurrence, Local', 'Skin Neoplasms'] | 15,565,812 | [['M01.060.116.100'], ['E04.555.080'], ['D27.505.519.124.035', 'D27.505.954.248.150', 'D27.888.569.035.035'], ['E02.319.267.200', 'E04.292.425'], ['E02.186'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.565'], ['A01.378.610'], ['C04.557.386.480.750.800', 'C15.604.515.569.480.750.800', 'C20.683.515.761.480.75... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Carbohydrate dependent targeting of cancer cells by bleomycin-microbubble conjugates. | Biotinylated bleomycin A(5) was attached to streptavidin-derivatized microbubbles, and a solution containing the conjugate was passed over a monolayer of cultured MCF-7 cells. The bleomycin-derivatized microbubbles adhered to the MCF-7 cells, and the association could be monitored by the use of a microscope. Three othe... | ['Antibiotics, Antineoplastic', 'Biotin', 'Bleomycin', 'Breast Neoplasms', 'Cell Line, Tumor', 'Drug Delivery Systems', 'Humans', 'Microbubbles', 'Streptavidin'] | 19,187,019 | [['D27.505.954.248.106'], ['D03.383.129.308.080', 'D08.211.096'], ['D09.400.420.110', 'D12.644.233.110'], ['C04.588.180', 'C17.800.090.500'], ['A11.251.210.190', 'A11.251.860.180'], ['E02.319.300'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.553'], ['D12.776.097.835']] | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of atracurium in cardiac surgery involving cardiopulmonary bypass with induced hypothermia. | Atracurium was administered by infusion to 12 anaesthetized patients undergoing cardiac surgery with cardiopulmonary bypass and induced hypothermia. Following an initial bolus dose of 0.6 mg kg-1, an infusion of atracurium was continued at an average rate of 0.0066 +/- 0.0003 mg kg-1 min-1 (0.4 mg kg-1 h-1) which was s... | ['Adult', 'Aged', 'Atracurium', 'Cardiopulmonary Bypass', 'Heart Valve Prosthesis', 'Humans', 'Hypothermia, Induced', 'Infusions, Parenteral', 'Isoquinolines', 'Middle Aged', 'Muscle Contraction', 'Neuromuscular Blocking Agents', 'Time Factors'] | 6,547,844 | [['M01.060.116'], ['M01.060.116.100'], ['D03.633.100.531.085.061'], ['E04.292.413'], ['E07.695.310'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.258.750'], ['E02.319.267.510'], ['D03.633.100.531'], ['M01.060.116.630'], ['G11.427.494'], ['D27.505.696.663.700.710'], ['G01.910.857']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Morphological and autoradiographic studies on the corneal and limbal epithelium of rabbits. | The investigation was centered on the morphological features of the conjunctiva-cornea transition (limbus) of the rabbit eye and the proliferative behavior of its epithelium. The eyes were processed for examination with light and electron microscopy, as well as for autoradiography after intravitreal injection of [(3)H]... | ['Animals', 'Autoradiography', 'Cell Proliferation', 'Conjunctiva', 'Epithelium, Corneal', 'Immunohistochemistry', 'Limbus Corneae', 'Male', 'Microscopy, Electron, Scanning', 'Rabbits'] | 18,213,705 | [['B01.050'], ['E01.370.225.750.132', 'E05.200.750.132', 'E05.799.256'], ['G04.161.750', 'G07.345.249.410.750'], ['A09.371.060.200', 'A09.371.337.168'], ['A09.371.060.217.325', 'A10.272.510'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.607.512', 'E05.200.750.551.512', 'E05.478.583', 'H01.158.10... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
With time changes of T-lymphocytes after Babesia infection in mice pretreated with Toxoplasma lysate antigen. | Adult female mice of the ICR/JCL strain were injected intraperitoneally with an emulsion of Toxoplasma lysate antigen (TLA; 100 micrograms per head) in light mineral oil (LMO) twice at 2 weeks' interval. Each mouse was inoculated intraperitoneally with 10(2) erythrocytes infected with Babesia rodhaini 2 weeks after the... | ['Animals', 'Antibodies, Protozoan', 'Antigens, Protozoan', 'Babesiosis', 'Erythrocyte Count', 'Female', 'Fluorescent Antibody Technique', 'Hematocrit', 'Hemoglobins', 'Leukocyte Count', 'Liver', 'Mice', 'Mice, Inbred ICR', 'Organ Size', 'Spleen', 'T-Lymphocytes', 'Thymus Gland', 'Toxoplasma'] | 3,310,464 | [['B01.050'], ['D12.776.124.486.485.114.252', 'D12.776.124.790.651.114.252', 'D12.776.377.715.548.114.252'], ['D23.050.293'], ['C01.610.701.688.122', 'C01.610.752.075', 'C01.610.752.625.122', 'C01.920.930.182', 'C22.674.710.122'], ['E01.370.225.500.195.107.330', 'E01.370.225.625.107.330', 'E05.200.500.195.107.330', 'E0... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Incidence of invasive cervical cancer in a cohort of HIV-seropositive women before and after the introduction of highly active antiretroviral therapy. | To assess whether the incidence of invasive cervical cancer (ICC) has changed as a result of highly active antiretroviral therapy (HAART), we conducted a prospective cohort study on the incidence of ICC before and after the introduction of HAART among Italian women with a known duration of HIV infection. We estimated t... | ['Adult', 'Aging', 'Anti-HIV Agents', 'Antiretroviral Therapy, Highly Active', 'Cohort Studies', 'Female', 'HIV Seropositivity', 'Humans', 'Incidence', 'Italy', 'Neoplasm Invasiveness', 'Proportional Hazards Models', 'Uterine Cervical Neoplasms'] | 11,317,082 | [['M01.060.116'], ['G07.345.124'], ['D27.505.954.122.388.077.088'], ['E02.319.310.075'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['C01.221.250.875.500', 'C01.221.812.640.400.500', 'C01.778.640.400.500', 'C01.925.782.815.616.400.500', 'C01.925.813.400.500', 'C20.673.480.500'], ['B0... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Vasopressin increases cytosolic free calcium concentration in glomerular mesangial cells. | Cytosolic free calcium concentration ([Ca2+]f) was determined in cultured rat glomerular mesangial cells under basal conditions and after exposure to arginine vasopressin (AVP) or angiotensin II (ANG II). [Ca2+]f was determined using quin 2 or fura-2, two intracellular fluorescent probes. [Ca2+]f was measured to be 102... | ['Adenylyl Cyclases', 'Aminoquinolines', 'Angiotensin II', 'Animals', 'Arginine Vasopressin', 'Benzofurans', 'Bucladesine', 'Calcium', 'Cytosol', 'Egtazic Acid', 'Fura-2', 'Glomerular Mesangium', 'Isoproterenol', 'Mathematics', 'Rats', 'Vasopressins', 'Verapamil'] | 3,014,901 | [['D08.811.520.650.200', 'D12.644.360.050', 'D12.776.476.050'], ['D03.633.100.810.050'], ['D06.472.699.094.078', 'D12.644.400.070.078', 'D12.644.456.073.041', 'D12.644.548.058.078', 'D12.776.631.650.070.078', 'D23.469.050.050.050'], ['B01.050'], ['D06.472.699.631.692.781.100', 'D12.644.400.900.100', 'D12.644.456.925.10... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
A biphasic pattern of anti-pre-S responses in acute hepatitis B virus infection. | The clinical relevance of the immune response to the translation products of the pre-S1 and pre-S2 regions of hepatitis B virus was examined by testing sequential serum samples from 17 patients with acute self-limited hepatitis B and from two patients in whom chronic liver disease developed. Anti-pre-S antibodies were ... | ['Acute Disease', 'Chronic Disease', 'DNA, Viral', 'Hepatitis B', 'Hepatitis B Antibodies', 'Hepatitis B Surface Antigens', 'Hepatitis B e Antigens', 'Hepatitis B virus', 'Humans', 'Immunoenzyme Techniques', 'Predictive Value of Tests', 'Prognosis', 'Protein Precursors'] | 2,258,143 | [['C23.550.291.125'], ['C23.550.291.500'], ['D13.444.308.568'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D12.776.124.486.485.114.254.450.504', 'D12.776.124.790.651.114.254.450.504', 'D12.776.377.715.548.114.254.450.504'], ['D23.050.327.495.500.475'], ['D23.050.327.495.500.... | ['Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Effects of nitric oxide synthesis on reperfusion injury and catecholamine responsiveness in a heterotopic rat heart-transplantation model. | Global myocardial ischemia and reperfusion injury play a major role in early postoperative graft dysfunction. In this study, the influence of nitric oxide (NO) on reperfusion injury and catecholamine sensitivity after ischemia was investigated in a heterotopic rat heart-transplantation model. After a 1-h ischemic prese... | ['Adrenergic beta-Agonists', 'Analysis of Variance', 'Animals', 'Arginine', 'Coronary Circulation', 'Diastole', 'Dobutamine', 'Enzyme Inhibitors', 'Heart Transplantation', 'Hemodynamics', 'Male', 'Myocardial Ischemia', 'Myocardial Reperfusion Injury', 'NG-Nitroarginine Methyl Ester', 'Nitric Oxide', 'Nitric Oxide Synth... | 9,475,263 | [['D27.505.519.625.050.100.200', 'D27.505.696.577.050.100.200'], ['E05.318.740.150', 'N05.715.360.750.125', 'N06.850.520.830.150'], ['B01.050'], ['D12.125.068.050', 'D12.125.095.104', 'D12.125.142.087'], ['G09.330.100.324'], ['G09.330.580.295', 'G11.427.494.554.250', 'G11.427.494.570.295'], ['D02.092.311.220', 'D02.092... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Iteratively reweighted LASSO for mapping multiple quantitative trait loci. | The iteratively reweighted least square (IRLS) method is mostly identical to maximum likelihood (ML) method in terms of parameter estimation and power of quantitative trait locus (QTL) detection. But the IRLS is greatly superior to ML in terms of computing speed and the robustness of parameter estimation. In conjunctio... | ['Bayes Theorem', 'Chromosome Mapping', 'Computational Biology', 'Computer Simulation', 'Databases, Genetic', 'Genome, Plant', 'Hordeum', 'Least-Squares Analysis', 'Likelihood Functions', 'Models, Genetic', 'Quantitative Trait Loci'] | 23,023,740 | [['E05.318.740.600.200', 'N05.715.360.750.625.150', 'N06.850.520.830.600.200'], ['E05.393.183'], ['H01.158.273.180', 'L01.313.124'], ['L01.224.160'], ['L01.313.500.750.300.188.400.325', 'L01.470.750.750.325'], ['G05.360.340.365'], ['B01.650.940.800.575.912.250.822.481'], ['E05.318.740.750.400', 'N05.715.360.750.695.440... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Information Science [L]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 |
The role of butyrate in the reverse transformation reaction in mammalian cells. | The reverse transformation reaction of Chinese hamster ovary cells from compact, epithelial-like, randomly growing, heavily knobbed, lectin reactive cells into stretched, tighly adherent, smooth-surfaced, lectin resistant, fibroblast-like cells normally elicited by dibutyryl cAMP can be produced to its complete extent ... | ['Butyrates', 'Cell Line', 'Cell Transformation, Neoplastic', 'Concanavalin A', 'Cyclic AMP', 'Testolactone', 'Theophylline'] | 201,654 | [['D02.241.081.114', 'D10.251.400.143'], ['A11.251.210'], ['C04.697.098.500', 'C23.550.727.098.500'], ['D12.776.503.499.500', 'D12.776.765.678.500'], ['D03.633.100.759.646.138.395', 'D13.695.462.200', 'D13.695.667.138.395', 'D13.695.827.068.395'], ['D04.210.500.054.079.129.782', 'D04.210.500.496.699'], ['D03.132.960.75... | ['Chemicals and Drugs [D]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Facile synthesis of Gd-doped CdTe quantum dots with optimized properties for optical/MR multimodal imaging. | Each imaging modality has its own merits and intrinsic limitations; therefore, combining two or more complementary imaging modalities has become an interesting area of research. Recently, magnetic ion-doped quantum dots have become an increasingly promising class of optical/magnetic resonance multimodal imaging probes ... | ['Animals', 'Axons', 'Cadmium Compounds', 'Chemistry Techniques, Synthetic', 'Gadolinium', 'Hydrogen-Ion Concentration', 'Magnetic Resonance Imaging', 'Mice', 'Multimodal Imaging', 'NIH 3T3 Cells', 'Optical Imaging', 'Quantum Dots', 'Tellurium'] | 28,865,047 | [['B01.050'], ['A08.675.542.145', 'A11.284.180.075', 'A11.671.137', 'A11.671.501.145'], ['D01.142'], ['E05.197', 'J01.897.836.249'], ['D01.268.558.362.484', 'D01.552.550.399.484'], ['G02.300'], ['E01.370.350.825.500'], ['B01.050.150.900.649.313.992.635.505.500'], ['E01.370.350.567'], ['A11.251.210.100.550', 'A11.329.22... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Mutagenesis in spermatozoa of Drosophila melanogaster by cross-linking agents depends on the mus(1)101+ gene product in the oocyte. | In Drosophila melanogaster the sex-linked gene must(1)101+ is essential for mutagenesis induced by a cross-linking agent: mature sperm mutagenized by nitrogen mustard (HN2) yield high frequencies of induced sex-linked recessive lethals if tested with wild-type oocytes but practically no recessive lethals if tested with... | ['Alleles', 'Animals', 'Crosses, Genetic', 'Drosophila melanogaster', 'Female', 'Genes, Lethal', 'Genes, Recessive', 'Genetic Linkage', 'Male', 'Mechlorethamine', 'Mutation', 'Phenotype', 'Sex Chromosomes', 'Spermatogenesis'] | 6,811,888 | [['G05.360.340.024.340.030'], ['B01.050'], ['E05.393.281'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['G05.360.340.024.340.350'], ['G05.360.340.024.340.415', 'G05.420.325'], ['G05.348'], ['D02.455.526.728.650.529'], ['G05.365.590'], ['G05.695'], ['A11.284.187.865', 'G05.360.162.865'], ['G04.152.650.624', 'G... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Ongoing Disparities in Prediagnosis Preexposure Prophylaxis Use Among Persons Recently Diagnosed With HIV in New York City, 2015-2017. | Objectives. To quantify sociodemographic disparities in prediagnosis preexposure prophylaxis (PrEP) use in persons recently diagnosed with HIV in New York City and assigned for partner services.Methods. We used partner services data from November 2015 to September 2017 from persons diagnosed with HIV in the past 12 mon... | ['Adult', 'African Americans', 'European Continental Ancestry Group', 'Female', 'HIV Infections', 'Healthcare Disparities', 'Hispanic Americans', 'Humans', 'Male', 'New York City', 'Pre-Exposure Prophylaxis'] | 31,318,600 | [['M01.060.116'], ['M01.686.508.100.100', 'M01.686.754.100'], ['M01.686.508.400'], ['C01.221.250.875', 'C01.221.812.640.400', 'C01.778.640.400', 'C01.925.782.815.616.400', 'C01.925.813.400', 'C20.673.480'], ['N04.590.374.380', 'N05.300.493'], ['M01.686.754.441'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.1... | ['Named Groups [M]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Metastatic signet ring cell carcinoma of unknown primary source. | An elderly man presented to the emergency department following a motorbike accident. He had sustained chest injuries and a grade 1 splenic laceration. He had a moderate amount of free fluid and some omental standing on trauma CT, which was concerning for occult malignancy. A follow-up CT 4 weeks later showed a marked p... | ['Accidents, Traffic', 'Aged', 'Ascites', 'Biopsy', 'Carcinoma, Signet Ring Cell', 'Humans', 'Incidental Findings', 'Male', 'Neoplasms, Unknown Primary', 'Omentum', 'Peritoneal Neoplasms', 'Tomography, X-Ray Computed'] | 24,536,055 | [['N06.850.135.392'], ['M01.060.116.100'], ['C23.550.081'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C04.557.470.200.025.415', 'C04.557.470.590.415'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.410'], ['C... | ['Health Care [N]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Postoperative port-site pain after gall bladder retrieval from epigastric vs. umbilical port in laparoscopic cholecystectomy: a randomized controlled trial. | OBJECTIVE: To determine whether gall bladder (GB) retrieval from umbilical port is associated with more pain at port site as compared to GB retrieval from epigastric port in adult patients undergoing four port elective laparoscopic cholecystectomy at a tertiary care hospital.METHODS: Adult patients, who were undergoing... | ['Adolescent', 'Adult', 'Aged', 'Cholecystectomy, Laparoscopic', 'Female', 'Gallbladder Diseases', 'Humans', 'Male', 'Middle Aged', 'Pain Measurement', 'Pain, Postoperative', 'Treatment Outcome', 'Umbilicus', 'Young Adult'] | 22,449,831 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['E04.210.120.172.140', 'E04.502.250.520.160'], ['C06.130.564'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.600.550.324'], ['C23.550.767.700', 'C23.888.592.612.832'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The evolution of the marine phosphate reservoir. | Phosphorus is a biolimiting nutrient that has an important role in regulating the burial of organic matter and the redox state of the ocean-atmosphere system. The ratio of phosphorus to iron in iron-oxide-rich sedimentary rocks can be used to track dissolved phosphate concentrations if the dissolved silica concentratio... | ['Animals', 'Aquatic Organisms', 'Atmosphere', 'Biological Evolution', 'Ferric Compounds', 'Geologic Sediments', 'History, Ancient', 'Ice Cover', 'Iron', 'Marine Biology', 'Oceans and Seas', 'Oxidation-Reduction', 'Oxygen', 'Phosphates', 'Phosphorus', 'Seawater', 'Silicon Dioxide'] | 20,981,096 | [['B01.050'], ['B05.080', 'G16.500.275.725.500.650.075'], ['G16.500.275.063', 'N06.230.300.100'], ['G05.045', 'G16.075'], ['D01.490.100'], ['G01.311.330', 'G16.500.320'], ['K01.400.470'], ['G01.311.400', 'G16.500.275.410.500', 'N06.230.291.500'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['H01.158.273.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Humanities [K]', 'Disciplines and Occupations [H]', 'Geographicals [Z]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Accumulation of amino acids by lysosomes incubated with amino acid methyl esters. | Rat liver lysosomal preparations incubated with 10(-5) M L-[4,5-3H]leucine methyl ester hydrolyzed the methyl ester and accumulated radioactivity within a particulate compartment. The acculated radioactivity was identified as free leucine by thin layer chromatography. Free leucine was not itself taken up by the lysosom... | ['Amino Acids', 'Animals', 'Biological Transport', 'Chloroquine', 'Esters', 'Kinetics', 'Liver', 'Lysosomes', 'Rats', 'Temperature', 'Tosylphenylalanyl Chloromethyl Ketone'] | 479,167 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Redox potential changes during ATP-dependent corrinoid reduction determined by redox titrations with europium(II)-DTPA. | Corrinoids are essential cofactors of enzymes involved in the C1 metabolism of anaerobes. The active, super-reduced [CoI ] state of the corrinoid cofactor is highly sensitive to autoxidation. In O-demethylases, the oxidation to inactive [CoII ] is reversed by an ATP-dependent electron transfer catalyzed by the activati... | ['Adenosine Triphosphate', 'Corrinoids', 'Europium', 'Oxidation-Reduction', 'Pentetic Acid'] | 31,359,509 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['D03.383.129.578.840.437', 'D03.633.400.909.437', 'D04.345.783.437'], ['D01.268.558.362.468', 'D01.552.550.399.468'], ['G02.700', 'G03.295.531'], ['D02.092.782.590', 'D02.241.081.018.639']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
High performance liquid chromatography of natural products. II. Direct biological correlation of components in the fermentation broth. | A portion of the eluent, during liquid chromatography of a fermentation broth, is applied directly to a paper strip at the same rate as the recording of the U. V. absorption. The paper is then placed on the agar inoculated with an appropriate test organism. This procedure permits direct correlation of biological activi... | ['Anti-Bacterial Agents', 'Chromatography, High Pressure Liquid', 'Culture Media', 'Fermentation'] | 721,709 | [['D27.505.954.122.085'], ['E05.196.181.400.300'], ['D27.720.470.305', 'E07.206'], ['G02.111.158.249', 'G03.191.249']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Carbonic anhydrase inhibitors. Inhibition studies of a coral secretory isoform by sulfonamides. | The inhibition of a newly cloned coral carbonic anhydrase (CA, EC 4.2.1.1) has been investigated with a series of sulfonamides, including some clinically used derivatives (acetazolamide, methazolamide, ethoxzolamide, dichlorophenamide, dorzolamide, brinzolamide, benzolamide, and sulpiride, or indisulam, a compound in c... | ['Amino Acid Sequence', 'Animals', 'Anthozoa', 'Carbonic Anhydrase Inhibitors', 'Carbonic Anhydrases', 'Humans', 'Molecular Sequence Data', 'Molecular Structure', 'Recombinant Proteins', 'Sequence Alignment', 'Sulfonamides'] | 19,520,577 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['B01.050.500.308.237'], ['D27.505.519.389.200'], ['D08.811.520.241.300.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.453.245.667'], ['G02.111.570', 'G02.466'], ['D12.776.828'], ['E05.393.751'], ['D02.065.884', 'D02.886.590.700']] | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Changes in spatial resolution for pattern and movement detection in clinical cases. | A simple and relatively fast method was used to evaluate visual performance: gratings of sinusoidal luminance profile, generated on the face of an oscilloscope, were reversed in contrast at a rate of 2 Hz. Under these conditions the patients could set separate contrast thresholds for seeing either the structure of a gr... | ['Adult', 'Evoked Potentials, Visual', 'Female', 'Form Perception', 'Humans', 'Male', 'Motion Perception', 'Pattern Recognition, Visual', 'Sensory Thresholds', 'Vision Disorders', 'Visual Acuity'] | 6,866,522 | [['M01.060.116'], ['G07.265.216.500.425', 'G11.561.200.500.425', 'G14.330'], ['F02.463.593.373', 'F02.463.593.778.435'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F02.463.593.932.567'], ['F02.463.593.524.500', 'F02.463.593.932.622'], ['F02.463.593.710'], ['C10.597.751.941', 'C11.966', 'C23.888.592.763.941'], [... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
A comparison of hypocholesterolemic activity of beta-sitosterol and beta-sitostanol in rats. | The hypocholesterolemic activity of beta-sitosterol and its hydrogenated product, beta-sitostanol (dihydrositosterol or stigmastanol) has been compared in young male rats. When cholesterol was included in the diet, sitostanol consistently exhibited significantly greater hypocholesterolemic activity than sitosterol. The... | ['Adipose Tissue', 'Adrenal Glands', 'Animals', 'Anticholesteremic Agents', 'Aorta', 'Cholesterol, Dietary', 'Dietary Fats', 'Feces', 'Lipid Metabolism', 'Male', 'Rats', 'Sitosterols', 'Sterols'] | 908,959 | [['A10.165.114'], ['A06.300.071'], ['B01.050'], ['D27.505.519.186.071.202', 'D27.505.954.557.500.202'], ['A07.015.114.056'], ['D04.210.500.247.808.197.225', 'D10.212.302.347', 'D10.570.938.208.222'], ['D10.212.302', 'G07.203.300.375', 'J02.500.375'], ['A12.459'], ['G03.458'], ['B01.050.150.900.649.313.992.635.505.700']... | ['Anatomy [A]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Duodenogastric reflux in children: measurement of phospholipids and trypsin in gastric content. | The duodenogastric reflux (DGR) is a suspected cause in some esogastric pathologies in adults: esophagitis, peptic gastric ulcers, stress ulcers, ulcers secondary to drugs, gastric cancer, and gastritis. The toxic substances of the reflux are essentially bile acids, lysolecithin, and trypsin. A number of diagnostic met... | ['Age Factors', 'Biomarkers', 'Child, Preschool', 'Duodenogastric Reflux', 'Gastric Juice', 'Gastric Mucosa', 'Humans', 'Infant', 'Infant, Newborn', 'N-Acetylneuraminic Acid', 'Phospholipids', 'Secretory Rate', 'Sialic Acids', 'Statistics as Topic', 'Trypsin'] | 2,324,893 | [['N05.715.350.075', 'N06.850.490.250'], ['D23.101'], ['M01.060.406.448'], ['C06.405.469.275.700', 'C06.405.748.240'], ['A12.200.307'], ['A03.556.875.875.440', 'A10.615.550.291'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['M01.060.703.520'], ['D02.241.081.844.562.668.050', 'D02.241.511.902.562.... | ['Health Care [N]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Using parasites as biological tags of fish populations: a dynamical model. | A simple model of macro-parasitic infections has been used to evaluate the potential use of parasites as biological tags of fish populations. In the model, the parasite-host interaction is regulated by a birth-death process, and parasites can only be acquired by the non-specific migratory host population in a particula... | ['Animals', 'Biomarkers', 'Fish Diseases', 'Fishes', 'Host-Parasite Interactions', 'Models, Biological', 'Movement', 'Parasites', 'Parasitic Diseases, Animal', 'Population Dynamics', 'Time Factors'] | 10,824,422 | [['B01.050'], ['D23.101'], ['C22.362'], ['B01.050.150.900.493'], ['G16.527.200.400'], ['E05.599.395'], ['G07.568', 'G11.427.410'], ['B01.050.500.714'], ['C01.610.701', 'C22.674'], ['I01.240.600', 'N01.224.625', 'N06.850.505.400.700'], ['G01.910.857']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Ruptured hepatic abscess caused by fish bone penetration of the duodenal wall: report of a case. | The accidental ingestion of a foreign body into the gastrointestinal tract is not uncommon; however, the development of a hepatic abscess secondary to foreign body perforation is extremely rare. We report the case of a ruptured hepatic abscess caused by fish bone penetration of the duodenal bulb, resulting in generaliz... | ['Aged', 'Animals', 'Bone and Bones', 'Diagnosis, Differential', 'Drainage', 'Duodenum', 'Fishes', 'Follow-Up Studies', 'Foreign-Body Migration', 'Humans', 'Liver', 'Liver Abscess', 'Male', 'Rupture, Spontaneous', 'Tomography, X-Ray Computed'] | 17,952,539 | [['M01.060.116.100'], ['B01.050'], ['A02.835.232', 'A10.165.265'], ['E01.171'], ['E02.309', 'E04.237'], ['A03.556.124.684.124', 'A03.556.875.249'], ['B01.050.150.900.493'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['C26.392.500'], ['B01.050.150.900.649.313.988.400.112.4... | ['Named Groups [M]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
[Regulation of the biosynthesis of extracellular phosphohydrolases in Penicillium brevicompactum]. | The effect of certain metabolites of Penicillium brevi-compactum on the biosynthesis of exocellular ribonucleases and phosphomonoesterase was studied. Their synthesis was found to be inhibited by RNA and AMP, as well as by high concentrations of these enzymes in the medium. The mechanism which regulates the biosynthesi... | ['Culture Media', 'Enzyme Activation', 'Enzyme Repression', 'Penicillium', 'Phosphoric Monoester Hydrolases'] | 212,670 | [['D27.720.470.305', 'E07.206'], ['G02.111.263', 'G03.328'], ['G05.308.320.300'], ['B01.300.381.662'], ['D08.811.277.352.650']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Epidemiology & Disease Control Program. Update: Salmonella enteritidis associated with shell eggs. February, 1992. | In previous articles in the Maryland Medical Journal we have reviewed the problem of Salmonella enteritidis associated with shell eggs. Cases and outbreaks continue to occur. Health care professionals need to be aware of the association between the consumption of raw or undercooked eggs or egg-containing foods and gast... | ['Eggs', 'Food Contamination', 'Humans', 'Maryland', 'Salmonella Infections', 'Salmonella enteritidis'] | 1,565,008 | [['G07.203.300.470', 'J02.500.470'], ['J01.576.423.850.730.500.249', 'N06.850.460.400', 'N06.850.601.500.249'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.107.567.875.075.418', 'Z01.107.567.875.500.500'], ['C01.150.252.400.310.821'], ['B03.440.450.425.800.200.300', 'B03.660.250.150.710.160.160']] | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 |
Influence of Tree Size and Application Rate on Expression of Thiamethoxam in Citrus and Its Efficacy Against Diaphorina citri (Hemiptera: Liviidae). | Neonicotinoids are a key group of insecticides used to manage Diaphorina citri Kuwayama (Hemiptera: Liviidae), in Florida citrus. Diaphorina citri is the vector of Candidatus Liberibacter asiaticus, the presumed causal agent of huanglongbing, a worldwide disease of citrus. A two-season field study was conducted to eval... | ['Animals', 'Citrus', 'Dose-Response Relationship, Drug', 'Hemiptera', 'Insecticides', 'Neonicotinoids', 'Nitro Compounds', 'Nymph', 'Oxazines', 'Plant Leaves', 'Thiamethoxam', 'Thiazoles', 'Trees'] | 29,471,401 | [['B01.050'], ['B01.650.940.800.575.912.250.875.177'], ['G07.690.773.875', 'G07.690.936.500'], ['B01.050.500.131.617.412'], ['D27.720.031.700.491', 'D27.888.723.491'], ['D03.383.464'], ['D02.640'], ['B05.500.650', 'G07.345.500.550.500.650'], ['D03.383.533'], ['A18.024.812'], ['D02.640.910', 'D02.886.675.884', 'D03.383.... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Electrical properties of the rabbit cortical collecting duct from obstructed kidneys after unilateral ureteral obstruction. Effects of renal decapsulation. | Ureteral obstruction causes impaired salt wastage and K+ secretion in the distal nephron segments, including the cortical collecting duct (CCD). Recently, we demonstrated that conductances of Na+ and K+ in the apical membrane, as well as the electrogenic Na(+)-K+ pump activity and the relative K+ conductance in the bas... | ['Animals', 'Biological Transport', 'Female', 'Kidney Cortex', 'Kidney Tubules, Collecting', 'Organ Size', 'Potassium', 'Rabbits', 'Sodium', 'Sodium-Potassium-Exchanging ATPase', 'Ureteral Obstruction'] | 7,962,530 | [['B01.050'], ['G03.143'], ['A05.810.453.324'], ['A05.810.453.736.560.510'], ['E01.370.600.115.100.660', 'E05.041.124.715', 'G07.100.100.660', 'G07.345.249.690'], ['D01.268.549.550', 'D01.268.557.575', 'D01.552.528.652', 'D01.552.547.650'], ['B01.050.150.900.649.313.968.700'], ['D01.268.549.750', 'D01.268.557.650', 'D0... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bridging the gap between basic and clinical investigation. | This article focuses on the increasing importance of effective communication between scientists and their clinical colleagues. Some recent and innovative programs to facilitate these interactions are also discussed. | ['Awards and Prizes', 'Humans', 'Research Support as Topic', 'Translational Medical Research', 'Workforce'] | 20,172,732 | [['K01.150'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N03.219.483.645'], ['H01.770.644.145.675'], ['N04.452.525']] | ['Humanities [K]', 'Organisms [B]', 'Health Care [N]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
Infertility Stigma Scale: A psychometric study in a Turkish sample. | PURPOSE: The purpose of the present study is to conduct the Turkish validity and reliability study of the Infertility Stigma Scale (ISS).DESIGN AND METHODS: This methodological study was conducted in an infertility polyclinic in Turkey. The sample consisted of 178 infertile women.FINDINGS: The validity of the four-fact... | ['Adult', 'Female', 'Humans', 'Infertility, Female', 'Psychiatric Status Rating Scales', 'Psychometrics', 'Reproducibility of Results', 'Social Stigma', 'Turkey'] | 30,680,737 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.351.500.365.700'], ['F04.711.513.653'], ['F04.711.780'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.520.445.725'], ['F01.145.813.840'], ['Z01.252.245.500.850']] | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Tuberculous laryngitis--a one year harvest. | We present nine patients with tuberculous laryngitis seen in our otolaryngology out-patient department during the year of 1983. Four patients were previously diagnosed as having pulmonary tuberculosis and were receiving or had received treatment for the complaint prior to our consultation. Of the nine patients, eight h... | ['Adult', 'Female', 'Humans', 'Laryngitis', 'Male', 'Middle Aged', 'Tuberculosis, Laryngeal', 'Tuberculosis, Pulmonary'] | 4,056,598 | [['M01.060.116'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C01.748.368', 'C08.360.535', 'C08.730.368', 'C09.400.535'], ['M01.060.116.630'], ['C01.150.252.410.040.552.846.696', 'C01.748.860', 'C08.360.860', 'C08.730.860', 'C09.400.860'], ['C01.150.252.410.040.552.846.899', 'C01.748.939', 'C08.381.922', 'C08.73... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
An Improved Genome Assembly for Drosophila navojoa, the Basal Species in the mojavensis Cluster. | Three North American cactophilic Drosophila species, D. mojavensis, D. arizonae, and D. navojoa, are of considerable evolutionary interest owing to the shift from breeding in Opuntia cacti to columnar species. The 3 species form the "mojavensis cluster" of Drosophila. The genome of D. mojavensis was sequenced in 2007 a... | ['Animals', 'Cactaceae', 'Chromosomes, Insect', 'Drosophila', 'Female', 'Gene Expression Profiling', 'Genome, Insect', 'Male', 'Molecular Sequence Annotation', 'Sequence Analysis, RNA', 'Software', 'Species Specificity'] | 30,423,125 | [['B01.050'], ['B01.650.940.800.575.912.250.198.500.200'], ['A11.284.187.440', 'G05.360.162.440'], ['B01.050.500.131.617.720.500.500.750.310.250'], ['E05.393.332'], ['G05.360.340.357'], ['E05.393.760.479', 'L01.453.245.667.580'], ['E05.393.760.710'], ['L01.224.900'], ['G16.824']] | ['Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
High versus standard clopidogrel maintenance dose after percutaneous coronary intervention and effects on platelet inhibition, endothelial function, and inflammation results of the ARMYDA-150 mg (antiplatelet therapy for reduction of myocardial damage during angioplasty) randomized study. | OBJECTIVES: This study was done to compare effects of high versus standard clopidogrel maintenance doses on platelet inhibition, inflammation, and endothelial function in patients undergoing percutaneous coronary intervention.BACKGROUND: Previous data suggested that clopidogrel has various biological actions in additio... | ['Aged', 'Angioplasty, Balloon, Coronary', 'Blood Platelets', 'C-Reactive Protein', 'Clopidogrel', 'Endothelial Cells', 'Female', 'Humans', 'Male', 'Middle Aged', 'Platelet Aggregation Inhibitors', 'Prospective Studies', 'Ticlopidine'] | 21,310,311 | [['M01.060.116.100'], ['E02.148.050.060.100', 'E04.100.376.719.100', 'E04.100.814.529.124.060.100', 'E04.100.814.529.968.050', 'E04.502.382.124.060.100', 'E04.502.382.968.050', 'E04.928.220.520.100', 'E05.157.016.060.100'], ['A11.118.188', 'A15.145.229.188'], ['D12.776.034.145', 'D12.776.124.050.120', 'D12.776.124.486.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
["Reflex--in a strict sense". Ivan Michajlovic Secenov and the founding myths of the 'Russian reflex empire']. | This paper aims to reconstruct Ivan Michajlovik Secenov's impact on reflex theory by looking at the different narratives which constitute his specific position in the history of science, where he is considered the Russian founder of a purely materialist framing of consciousness and behaviour, the father figure of objec... | ['Behavior', 'Behavioral Research', 'Brain', 'Consciousness', 'Culture', 'History, 19th Century', 'History, 20th Century', 'Humans', 'Neurology', 'Politics', 'Psychology', 'Psychophysiology', 'Reflex', 'Russia'] | 19,824,305 | [['F01.145'], ['F04.096.144', 'H01.770.644.108'], ['A08.186.211'], ['F02.463.188.409', 'F02.830.233'], ['I01.076.201.450', 'I01.880.853.100'], ['K01.400.504.937'], ['K01.400.504.968'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['H02.403.600'], ['I01.738'], ['F04.096.628'], ['E02.190.525.812', 'F02.830', 'F04.096... | ['Psychiatry and Psychology [F]', 'Disciplines and Occupations [H]', 'Anatomy [A]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Humanities [K]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 |
Claims in advertisements for antihypertensive drugs in a Dutch medical journal. | BACKGROUND: Advertising claims must not conflict with the official summary of product characteristics. After a drug has been approved, new clinical evidence may become available.AIMS: To determine how the pharmaceutical industry deals with evolving clinical evidence in advertising claims for antihypertensive drugs, and... | ['Advertising', 'Antihypertensive Agents', 'Drug Industry', 'Evidence-Based Medicine', 'Humans', 'Netherlands', 'Peer Review', 'Publishing', 'Reproducibility of Results', 'Truth Disclosure'] | 17,278,989 | [['J01.219.687.274', 'L01.143.050'], ['D27.505.954.411.162'], ['J01.576.655.750'], ['H02.249.750', 'H02.403.200.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.542.651'], ['F01.829.316.549', 'I01.880.604.640', 'N03.706.700'], ['L01.737'], ['E05.318.370.725', 'E05.337.851', 'N05.715.360.325.685', 'N06.850.... | ['Technology, Industry, and Agriculture [J]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Analytical, Diagnostic and The... | 0 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 1 |
[Brain abscess following the use of skull traction with Gardner-Wells tongs]. | Brain abscess after insertion of skull traction is a rare and serious complication. Its development is secondary to superficial infection. Adequate preventive measures have to be taken: proper sterile dressing and daily care. Signs of local irritation are not always synonymous with skull migration. When gradual looseni... | ['Adult', 'Axis, Cervical Vertebra', 'Bandages', 'Bone Nails', 'Brain Abscess', 'Cervical Vertebrae', 'Humans', 'Male', 'Odontoid Process', 'Skin Care', 'Skin Diseases, Bacterial', 'Spinal Fractures', 'Traction'] | 10,546,398 | [['M01.060.116'], ['A02.835.232.834.151.383'], ['E07.101'], ['E07.695.370.249', 'E07.858.442.660.460.249', 'E07.858.690.725.460.249'], ['C01.207.090', 'C01.830.025.160', 'C10.228.140.116', 'C10.228.228.090'], ['A02.835.232.834.151'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A02.835.232.834.151.383.668'], ['E0... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Scientific rationale for changing lower water temperature limits for triathlon racing to 12°C with wetsuits and 16°C without wetsuits. | OBJECTIVES: To provide a scientific rationale for lower water temperature and wetsuit rules for elite and subelite triathletes.METHODS: 11 lean, competitive triathletes completed a 20 min flume swim, technical transition including bike control and psychomotor testing and a cycle across five different wetsuit and water ... | ['Adolescent', 'Adult', 'Bicycling', 'Body Temperature', 'Female', 'Humans', 'Male', 'Middle Aged', 'Protective Clothing', 'Running', 'Swimming', 'Temperature', 'Water'] | 29,720,479 | [['M01.060.057'], ['M01.060.116'], ['I03.450.642.845.140'], ['E01.370.600.875.374', 'G07.110'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E07.700.600', 'J01.637.215.600', 'J01.637.708.560.875'], ['G11.427.410.568.610', 'G11.427.410.698.277.750', 'I03.350.750', 'I03.450.642.845.610'], ['G11... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 |
Educational strategies and atraumatic restorative treatment effect on salivary characteristics: A controlled clinical trial. | OBJECTIVE: To evaluate educational strategies and atraumatic restorative treatment (ART)-restoration impact on salivary physicochemical and microbiological characteristics.DESIGN: Two groups of 6- to 7-year-old children were included: GART , with at least one decayed primary molar (n = 36), submitted to four sessions o... | ['Biofilms', 'Calcium', 'Child', 'Dental Caries', 'Dental Restoration, Permanent', 'Female', 'Gingivitis', 'Humans', 'Hydrogen-Ion Concentration', 'Male', 'Oral Health', 'Patient Education as Topic', 'Phosphorus', 'Saliva', 'Streptococcus mutans'] | 28,650,087 | [['A20.593', 'G06.120'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['M01.060.406'], ['C07.793.720.210'], ['E06.323.428', 'E06.780.346.737', 'E07.695.190.190'], ['C01.408', 'C07.465.714.258.480'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.300'], ['N01.400.535'], ['I02.233.332.500', 'N02.421.726... | ['Anatomy [A]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
The reasons that many radiology practices don't use off-hours services. | PURPOSE: To compare radiology practices that use external, internal, and no off-hours services.METHODS: From August 2005 to June 2006, 300 nonspecialty hospitals randomly selected from the AHA Guide 2005 Edition were contacted by telephone, e-mail, and mail, with attempts made to speak to the chiefs of radiology. A tot... | ['After-Hours Care', 'Hospitals', 'Professional Practice', 'Radiology', 'Teleradiology', 'United States'] | 18,657,784 | [['N04.590.374.034', 'N05.300.049'], ['N02.278.421'], ['N04.452.758'], ['H02.403.740'], ['E05.920.700', 'H02.010.850.700', 'H02.403.840.700', 'L01.178.847.652.700', 'N04.452.515.825.500', 'N04.590.374.800.700'], ['Z01.107.567.875']] | ['Health Care [N]', 'Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 |
[The status of ascorbate oxidation-reduction system of blood in patients with chronic pancreatitis throughout parenteral nutrition]. | There was conducted operative treatment of patients with complicated chronic pancreatitis. Intravenous infusion of aminoacid cocktail with enhanced content of glutamine, methionine with the selenium addition was applied in the complex of therapy. Under the influence of modified cocktail during 3 days there was observed... | ['Adult', 'Ascorbate Oxidase', 'Chronic Disease', 'Female', 'Humans', 'Male', 'Middle Aged', 'Oxidation-Reduction', 'Pancreatitis', 'Parenteral Nutrition'] | 10,584,506 | [['M01.060.116'], ['D08.811.682.180'], ['C23.550.291.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G02.700', 'G03.295.531'], ['C06.689.750'], ['E02.421.505', 'E02.642.500.505']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Identification of I:A mismatch base-pairing structure in DNA. | Deoxyoligonucleotides containing deoxyinosine residues at positions corresponding to ambiguous nucleotides derived from an amino acid sequence have been successfully used as hybridization probes. It is assumed that the hypoxanthine residue can make base pairs with multiple bases. In order to obtain direct evidence for ... | ['Base Composition', 'DNA', 'Deoxyadenosines', 'Inosine', 'Magnetic Resonance Spectroscopy', 'Nucleic Acid Conformation', 'Nucleic Acid Heteroduplexes', 'Oligodeoxyribonucleotides'] | 3,495,532 | [['G02.111.080'], ['D13.444.308'], ['D03.633.100.759.590.138.325', 'D13.570.230.229', 'D13.570.583.138.325'], ['D03.633.100.759.590.616', 'D13.570.583.616', 'D13.570.800.573'], ['E05.196.867.519'], ['G02.111.570.820.486', 'G05.360.580'], ['D13.444.500'], ['D13.695.578.424.450']] | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
American attitudes toward health maintenance organizations. | The growth of the health maintenance organization movement (HMO) in recent years is evidence of continuing interest by the American public in prepaid health care. The trustees and officers of the Henry J. Kaiser Family Foundation believe that up-to-date knowledge about consumer attitudes helps to address issues pertine... | ['Consumer Behavior', 'Health Maintenance Organizations', 'Public Opinion', 'United States'] | 10,250,753 | [['F01.145.236'], ['N03.219.521.576.343.800.400', 'N03.219.521.576.343.925.400', 'N04.452.758.244.425', 'N04.590.374.410.400'], ['I01.880.630.548'], ['Z01.107.567.875']] | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Treatments for acute and old distal radius fracture with lunate dislocation. | PURPOSE: Our study was undertaken to determine the correct treatment protocol for distal radius fracture with lunate anterior dislocation.METHODS: From 2000 to 2007, 58 patients (36 with acute injury and 22 with old injury) with distal radius fracture with lunate anterior dislocation were enrolled in the study. Among a... | ['Adolescent', 'Adult', 'Aged', 'Female', 'Humans', 'Joint Dislocations', 'Lunate Bone', 'Male', 'Middle Aged', 'Radius Fractures', 'Time Factors', 'Treatment Outcome', 'Wrist Injuries', 'Young Adult'] | 23,412,451 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C05.550.518', 'C26.289'], ['A02.835.232.087.319.150.500'], ['M01.060.116.630'], ['C26.088.268.556', 'C26.404.562'], ['G01.910.857'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800'], ['C26.088.906... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Vitreous loss during cataract surgery: prevention and optimal management. | Vitreous loss during cataract surgery is associated with a poor visual outcome. Experienced surgeons and those performing a high volume of cataract operations have lower rates of vitreous loss. Risk stratification systems, which allow prediction of intraoperative complications from preoperative criteria exist, so that ... | ['Cataract Extraction', 'Clinical Competence', 'Contraindications', 'Female', 'Humans', 'Intraoperative Complications', 'Lens, Crystalline', 'Male', 'Patient Education as Topic', 'Phacoemulsification', 'Prognosis', 'Risk Assessment', 'Visual Acuity', 'Vitrectomy', 'Vitreous Body'] | 18,292,788 | [['E04.540.825.249'], ['I02.399.630.210', 'N04.761.210', 'N05.715.175'], ['E02.208'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C23.550.505'], ['A09.371.060.500'], ['I02.233.332.500', 'N02.421.726.407.680'], ['E04.540.825.249.704', 'E04.943.875'], ['E01.789'], ['E05.318.740.600.800.715', 'N04.452.871.715', 'N0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
Penile pyoderma gangrenosum: successful treatment with colchicine. | Pyoderma gangrenosum is an ulcerative skin disease with variable clinical outcomes. The diagnosis is based on clinical features and exclusion of other ulcerative diseases. To date, a specific treatment is not known. Since the disease can be destructive, aggressive treatment is preferable. Here, we present a patient wit... | ['Adult', 'Colchicine', 'Humans', 'Male', 'Penile Diseases', 'Penis', 'Pyoderma Gangrenosum', 'Skin', 'Tubulin Modulators'] | 18,986,476 | [['M01.060.116'], ['D03.132.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C12.294.494'], ['A05.360.444.492'], ['C17.800.695.675', 'C17.800.862.675', 'C17.800.893.675'], ['A17.815'], ['D27.505.519.593.249.500']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Technological and life cycle assessment of organics processing odour control technologies. | As more municipalities and communities across developed world look towards implementing organic waste management programmes or upgrading existing ones, composting facilities are emerging as a popular choice. However, odour from these facilities continues to be one of the most important concerns in terms of cost & effec... | ['Air Pollution', 'Conservation of Natural Resources', 'Environment', 'Environmental Monitoring', 'Odorants'] | 25,981,938 | [['N06.850.460.100'], ['J01.256', 'N06.230.080'], ['G16.500.275', 'N06.230'], ['N06.850.460.350.080', 'N06.850.780.375'], ['G16.500.275.640', 'N06.230.480']] | ['Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Isl1â Overexpression With Key â Cell Transcription Factors Enhances Glucose-Responsive Hepatic Insulin Production and Secretion. | Adenoviral gene transfer of key â cell developmental regulators including Pdx1, Neurod1, and Mafa (PDA) has been reported to generate insulin-producing cells in the liver. However, PDA insulin secretion is transient and glucose unresponsive. Here, we report that an additional â cell developmental regulator, insulin gen... | ['Animals', 'Basic Helix-Loop-Helix Transcription Factors', 'Female', 'Gene Expression Regulation', 'Glucose', 'Homeodomain Proteins', 'Hyperglycemia', 'Insulin', 'Insulin Secretion', 'Insulin-Secreting Cells', 'LIM-Homeodomain Proteins', 'Liver', 'Maf Transcription Factors, Large', 'Male', 'Mice', 'Mice, Inbred ICR', ... | 29,220,426 | [['B01.050'], ['D12.776.260.103', 'D12.776.930.125'], ['G05.308'], ['D09.947.875.359.448'], ['D12.776.260.400'], ['C18.452.394.952'], ['D06.472.699.587.200.500.625', 'D12.644.548.586.200.500.625'], ['G03.442', 'G07.475'], ['A03.734.414.131', 'A06.300.414.087', 'A06.390.131', 'A11.382.625.092', 'A11.436.294.092'], ['D12... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Diseases [C]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Beyond Angiogenesis: Exploiting Angiocrine Factors to Restrict Tumor Progression and Metastasis. | Looking beyond tumor angiogenesis, the past decade has witnessed a fundamental change of paradigm with the discovery that the vascular endothelium does not just respond to exogenous cytokines, but exerts active "angiocrine" gatekeeper roles, controlling their microenvironment in an instructive manner. While vascular ni... | ['Angiogenesis Inhibitors', 'Animals', 'Antineoplastic Combined Chemotherapy Protocols', 'Carcinogenesis', 'Disease Models, Animal', 'Disease Progression', 'Drug Evaluation, Preclinical', 'Endothelial Cells', 'Endothelium, Vascular', 'Humans', 'Neoplasm Metastasis', 'Neoplasms', 'Neoplastic Cells, Circulating', 'Neovas... | 31,831,463 | [['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['B01.050'], ['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['C04.697.098', 'C23.550.727.098'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C23.550.291.656'], ['E05.290.750', 'E05.337.550'], ['A11.436.275'], ['A07.015.700.5... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Angiogenic activity of Onchocerca volvulus recombinant proteins similar to vespid venom antigen 5. | Although the mechanisms underlying the host inflammatory response in ocular onchocerciasis have been examined, the role of particular parasite proteins in this process remains largely unexplored. Recently, it was found that one of the most abundant expressed sequence tags in Onchocerca volvulus infective larvae encoded... | ['Animals', 'Antigens, Helminth', 'Cornea', 'Helminth Proteins', 'Mice', 'Mice, Inbred BALB C', 'Molecular Sequence Data', 'Neovascularization, Pathologic', 'Onchocerca volvulus', 'Onchocerciasis, Ocular', 'Phylogeny', 'Recombinant Fusion Proteins', 'Sequence Analysis, DNA', 'Wasp Venoms'] | 10,960,168 | [['B01.050'], ['D23.050.223'], ['A09.371.060.217'], ['D12.776.419'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.338', 'B01.050.150.900.649.313.992.635.505.500.400.338'], ['L01.453.245.667'], ['C23.550.589.500'], ['B01.050.500.500.294.400.937.463.510.850'], ['C01.610.300.562', 'C01.610.335.50... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Information Science [L]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
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