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Echocardiography in the Assessment of Left Atrial Pressure After Pediatric Heart Surgery: A Comparison Study With Measurements Obtained From Left Atrial Catheter. | BACKGROUND: Correlation between ventricular end-diastolic pressure and pulsed Doppler and tissue Doppler-derived E/e' ratio has been widely reported in adults but scarcely studied in children with congenital heart diseases. This ratio is defined as the relationship between diastolic transmitral flow velocity (cm/s; E) ... | ['Adolescent', 'Atrial Pressure', 'Cardiac Catheterization', 'Cardiac Surgical Procedures', 'Child', 'Child, Preschool', 'Echocardiography, Doppler', 'Female', 'Heart Atria', 'Heart Defects, Congenital', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Prospective Studies'] | 26,180,162 | [['M01.060.057'], ['G09.330.040.600', 'G09.330.380.037'], ['E01.370.370.380.140', 'E02.148.442', 'E05.157.250'], ['E04.100.376', 'E04.928.220'], ['M01.060.406'], ['M01.060.406.448'], ['E01.370.350.130.750.220', 'E01.370.350.850.220.220', 'E01.370.350.850.850.220', 'E01.370.370.380.220.220'], ['A07.541.358'], ['C14.240.... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Diseases [C]', 'Organisms [B]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Microcirculatory methods for evaluating the effect of vasoactive drugs in clinical practice. | Microcirculatory methods have to be used in order to be able to evaluate the effect of vasoactive drugs in ischemic skin areas. During the past two decades several new such techniques for studying the microcirculation in man have been developed. These techniques have shown to be of great value for evaluating drug effec... | ['Capillaries', 'Cardiovascular Agents', 'Humans', 'Lasers', 'Microcirculation', 'Regional Blood Flow', 'Skin'] | 3,788,603 | [['A07.015.461.165'], ['D27.505.954.411'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E07.632.490', 'E07.710.520'], ['G09.330.100.645'], ['G09.330.100.780'], ['A17.815']] | ['Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Bridges to life: evaluation of an in-prison restorative justice intervention. | Restorative justice initiatives have been identified as primarily, if not exclusively, useful as a "front-end" diversionary option reserved for non violent property crimes and minor assaults. In-prison restorative justice programs are rare and have not been examined for their impact on recidivism. Bridges to Life (BTL)... | ['Adult', 'Criminal Law', 'Criminal Psychology', 'Female', 'Humans', 'Male', 'Prisoners', 'Program Evaluation', 'Religion', 'Social Responsibility', 'Texas'] | 16,440,874 | [['M01.060.116'], ['I01.198.290', 'I01.880.604.583.100'], ['F02.784.240'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.729'], ['E05.337.820', 'N04.761.685', 'N05.715.360.650'], ['K01.844'], ['F01.829.500.760', 'K01.752.566.869'], ['Z01.107.567.875.760.750']] | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Humanities [K]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Left hemispheric activation in depersonalization disorder: a case report. | Depersonalization disorder is classified in DSM-III-R (APA 1987) as a dissociative disorder characterized by altered perception or experience of the self. To date, there are no known reports of the neurobiological features of this disorder. We report clinical and biological correlates in a patient with depersonalizatio... | ['Adult', 'Brain', 'Depersonalization', 'Functional Laterality', 'Humans', 'Male', 'Neuropsychological Tests'] | 1,525,279 | [['M01.060.116'], ['A08.186.211'], ['F01.145.126.300'], ['F02.830.297.425', 'G11.561.225.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['F04.711.513']] | ['Named Groups [M]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Interleukin-3 production by mast cells from human lung. | The cytokine interleukin (IL)-3 is important in the proliferation of eosinophils and basophils in the airway. We investigated IL-3 production by human lung mast cells as a possible mechanism of the airway inflammation constituting the late asthmatic response. Mast cells were purified using affinity magnetic selection w... | ['Antibodies, Anti-Idiotypic', 'Humans', 'Immunoglobulin E', 'Immunohistochemistry', 'Interleukin-3', 'Kinetics', 'Lung', 'Mast Cells', 'RNA, Messenger', 'Receptors, IgE', 'Recombinant Proteins', 'Stem Cell Factor'] | 10,065,759 | [['D12.776.124.486.485.114.071', 'D12.776.124.790.651.114.071', 'D12.776.377.715.548.114.071'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.124.486.485.114.619.312', 'D12.776.124.790.651.114.619.312', 'D12.776.377.715.548.114.619.312'], ['E01.370.225.500.607.512', 'E01.370.225.750.551.512', 'E05.200.500.... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Phenomena and Processes [G]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
The Rotterdam Study: 2012 objectives and design update. | The Rotterdam Study is a prospective cohort study ongoing since 1990 in the city of Rotterdam in The Netherlands. The study targets cardiovascular, endocrine, hepatic, neurological, ophthalmic, psychiatric, dermatological, oncological, and respiratory diseases. As of 2008, 14,926 subjects aged 45 years or over comprise... | ['Aged', 'Aged, 80 and over', 'Chronic Disease', 'Cohort Studies', 'Epidemiologic Research Design', 'Female', 'Humans', 'Incidence', 'Life Expectancy', 'Male', 'Middle Aged', 'Netherlands', 'Population Dynamics', 'Risk Assessment'] | 21,877,163 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['C23.550.291.500'], ['E05.318.372.500.750', 'N05.715.360.330.500.750', 'N06.850.520.450.500.750'], ['E05.318.370', 'N05.715.360.325', 'N06.850.520.445'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375', 'N01.224.935.597.500', 'N06.850.505.400.9... | ['Named Groups [M]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Adaptation of Rabensburg virus (RBGV) to vertebrate hosts by experimental evolution. | Rabensburg virus (RBGV; Flaviviridae, Flavivirus) has been classified as both a novel flavivirus and a unique lineage of West Nile virus (WNV). RBGV and WNV share approximately 76% sequence homology, yet RBGV does not replicate to high viral titers within vertebrate cell lines at physiological temperatures and has not ... | ['Adaptation, Biological', 'Animals', 'Cell Line', 'Chlorocebus aethiops', 'Directed Molecular Evolution', 'Ducks', 'Flavivirus', 'Genetic Fitness', 'Genome, Viral', 'HEK293 Cells', 'Host Microbial Interactions', 'Humans', 'Mutation', 'Reverse Genetics', 'Sequence Homology', 'Vero Cells', 'Virus Replication', 'West Nil... | 30,554,071 | [['G16.012'], ['B01.050'], ['A11.251.210'], ['B01.050.150.900.649.313.988.400.112.199.120.126.110'], ['E05.393.420.175'], ['B01.050.150.900.248.050.200', 'B01.050.150.900.248.690.345'], ['B04.820.578.344.350'], ['G05.347'], ['G05.360.340.358.840'], ['A11.251.210.172.750', 'A11.436.334'], ['G06.373', 'G16.527'], ['B01.0... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Sodium movements in the human red blood cell. | Measurements were made of the sodium outflux rate constant, (o)k(Na), and sodium influx rate constant, (i)k(Na), at varying concentrations of extracellular (Na(o)) and intracellular (Na(c)) sodium. (o)k(Na) increases with increasing [Na(o)] in the presence of extracellular potassium (K(o)) and in solutions containing o... | ['Biological Transport', 'Erythrocytes', 'Humans', 'Male', 'Models, Chemical', 'Ouabain', 'Potassium', 'Sodium', 'Sodium Isotopes'] | 5,476,387 | [['G03.143'], ['A11.118.290', 'A11.443.240', 'A15.145.229.334'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.599.495'], ['D04.210.500.155.580.130.750.600', 'D09.408.180.810.600'], ['D01.268.549.550', 'D01.268.557.575', 'D01.552.528.652', 'D01.552.547.650'], ['D01.268.549.750', 'D01.268.557.650', 'D01.552.528... | ['Phenomena and Processes [G]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The submicrosomal distribution of dolichyl phosphate and dolichyl phosphate phosphatase in rat liver. | Rat liver microsomes were isolated and fractionated into Golgi, smooth endoplasmic reticulum (SER), and rough endoplasmic reticulum (RER), and the purity of these preparations was determined. The dolichyl phosphate (Dol-P) content of whole microsomes and of each of the submicrosomal fractions was estimated using high p... | ['Animals', 'Cell Fractionation', 'Dolichol Phosphates', 'Endoplasmic Reticulum', 'Golgi Apparatus', 'Male', 'Microsomes, Liver', 'Phosphoric Monoester Hydrolases', 'Polyisoprenyl Phosphates', 'Rats', 'Rats, Inbred Strains', 'Tissue Distribution'] | 6,317,680 | [['B01.050'], ['E05.242.251'], ['D02.033.318.250', 'D02.033.415.230.250', 'D02.455.849.366.250', 'D02.455.849.690.250', 'D02.705.400.725.200', 'D10.289.230.250'], ['A11.284.430.214.190.875.248'], ['A11.284.430.214.190.875.336'], ['A11.284.835.540.541'], ['D08.811.277.352.650'], ['D02.455.849.690', 'D02.705.400.725'], [... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
There is no difference in the plasma cortisol level between women with body mass index (BMI) greater than or equal 25 kg/m² and polycystic ovary syndrome and the control group without polycystic ovary syndrome and BMI 25 kg/m². | A 4-8% of women of reproductive age suffer from the polycystic ovary syndrome (PCOS). The clinical and/ or biochemical hyperandrogenemia is found up to 75% of women with PCOS. It is unclear whether the hyperandogenemia in PCOS is caused directly by this disorder or by obesity. The recent studies have shown that the cor... | ['Adult', 'Body Mass Index', 'Female', 'Humans', 'Hydrocortisone', 'Obesity', 'Overweight', 'Polycystic Ovary Syndrome', 'Young Adult'] | 27,526,420 | [['M01.060.116'], ['E01.370.600.115.100.125', 'E05.041.124.125', 'G07.100.100.125', 'N06.850.505.200.100.175'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D04.210.500.745.745.654.600', 'D06.472.040.585.353.476', 'D06.472.040.585.478.392'], ['C18.654.726.500', 'C23.888.144.699.500', 'E01.370.600.115.100.160.120.... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Is compartment pressure related to plasma colloid osmotic pressure, in patients during and after cardiac surgery? | Haemodilution is always considerable during cardiopulmonary bypass (CPB). If this extra fluid sits in the muscle compartments then a corresponding rise in the compartment pressure (CP) is to be expected. The aim of this study was to measure pressure changes in a body compartment with new equipment, the MTC (Microtransd... | ['Aged', 'Body Fluid Compartments', 'Cardiac Surgical Procedures', 'Cardiopulmonary Bypass', 'Colloids', 'Humans', 'Male', 'Middle Aged', 'Muscle, Skeletal', 'Osmotic Pressure', 'Plasma', 'Pressure', 'Time Factors', 'Transducers, Pressure', 'Water-Electrolyte Balance'] | 11,334,197 | [['M01.060.116.100'], ['A10.082', 'A12.207.180'], ['E04.100.376', 'E04.928.220'], ['E04.292.413'], ['D20.280', 'D26.255.165'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['A02.633.567', 'A10.690.552.500'], ['G01.374.715.578', 'G02.640.249', 'G02.723.661'], ['A12.207.152.693', 'A12.207.270.695... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Characterization of a chromosomal gene encoding type B beta-lactamase in phage group II isolates of Staphylococcus aureus. | In contrast to most Staphylococcus aureus isolates in which the gene for staphylococcal beta-lactamase (blaZ) is plasmid borne, isolates typeable by group II bacteriophages frequently carry blaZ on the chromosome. Furthermore, the chromosomal gene encodes the type B variant of staphylococcal beta-lactamase for which th... | ['Bacteriophage Typing', 'Base Sequence', 'Blotting, Southern', 'Cephaloridine', 'Cephalosporins', 'Chromosomes, Bacterial', 'Culture Media', 'DNA, Bacterial', 'Molecular Sequence Data', 'Penicillins', 'Plasmids', 'Staphylococcus aureus', 'beta-Lactamases'] | 9,835,509 | [['E01.370.225.875.150.125.150', 'E05.200.875.150.125.150'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['E05.196.401.114', 'E05.301.300.087', 'E05.601.150'], ['D02.065.589.099.249.210', 'D02.886.665.074.210', 'D03.633.100.300.249.210'], ['D02.065.589.099.249', 'D02.886.665.074', 'D03.633.100.300.249'],... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Colonic transit and anorectal manometry in children with severe brain damage. | OBJECTIVE: This study was conceived to determine the physiologic abnormalities in distal gastrointestinal motility that are responsible for constipation in brain-damaged children.DESIGN: Colonic transit and anorectal manometry were evaluated in 16 children with severe brain damage and constipation (mean age +/- SD; 5.1... | ['Anal Canal', 'Brain Damage, Chronic', 'Child', 'Child, Preschool', 'Chronic Disease', 'Colon', 'Constipation', 'Defecation', 'Female', 'Gastrointestinal Motility', 'Gastrointestinal Transit', 'Humans', 'Infant', 'Male', 'Manometry', 'Rectum'] | 8,036,068 | [['A03.556.124.526.070', 'A03.556.249.249.070'], ['C10.228.140.140'], ['M01.060.406'], ['M01.060.406.448'], ['C23.550.291.500'], ['A03.556.124.526.356', 'A03.556.249.249.356'], ['C23.888.821.150'], ['G10.261.165'], ['G10.261.360'], ['E01.370.372.310', 'G10.261.360.525'], ['B01.050.150.900.649.313.988.400.112.400.400'],... | ['Anatomy [A]', 'Diseases [C]', 'Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Excretion of BSE and scrapie prions in stools from murine models. | Faeces from infected animals have been suggested as a potential source of contamination and transmission of prion diseases in the environment. This work describes the development of a procedure for the detection of PrP(res) in stools which is based on a detergent-based extraction and immunoprecipitation (IP). The proce... | ['Animals', 'Blotting, Western', 'Cattle', 'Disease Models, Animal', 'Encephalopathy, Bovine Spongiform', 'Feces', 'Mice', 'Mice, Transgenic', 'PrPSc Proteins', 'Prions', 'Scrapie', 'Species Specificity', 'Time Factors'] | 18,395,370 | [['B01.050'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['B01.050.150.900.649.313.500.380.271'], ['C22.232', 'E05.598.500', 'E05.599.395.080'], ['C01.207.800.260', 'C10.228.228.800.260', 'C10.574.843.300', 'C22.196.250'], ['A12.459'], ['B01.050.150.900.649.313.... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A mutational analysis of Caenorhabditis elegans in space. | The International Caenorhabditis elegans Experiment First Flight (ICE-First) was a project using C. elegans as a model organism to study the biological effects of short duration spaceflight (11 days in the International Space Station). As a member of the ICE-First research team, our group focused on the mutational effe... | ['Animals', 'Caenorhabditis elegans', 'Caenorhabditis elegans Proteins', 'Calmodulin-Binding Proteins', 'Chromosome Mapping', 'Cosmic Radiation', 'Crossing Over, Genetic', 'DNA Mutational Analysis', 'Genes, Lethal', 'Muscle Proteins', 'Mutation', 'Poly C', 'Poly G', 'Space Flight', 'Telomere', 'Translocation, Genetic'] | 16,765,996 | [['B01.050'], ['B01.050.500.500.294.400.875.660.250.250'], ['D12.776.419.500'], ['D12.776.157.142'], ['E05.393.183'], ['G01.060.185', 'G01.750.750.235', 'G16.500.200', 'N06.230.300.100.300'], ['G05.728.615.200'], ['E05.393.760.700.300'], ['G05.360.340.024.340.350'], ['D12.776.210.500'], ['G05.365.590'], ['D13.695.578.5... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Technology, Industry, and Agriculture [J]', 'Anatomy [A]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Results following resection for stage IV gastric cancer; are better outcomes observed in selected patient subgroups? | BACKGROUND: Patients who present with stage IV gastric cancer are not commonly managed with surgical resection as effective palliation can usually be accomplished with systemic chemotherapy, endoscopic stenting, or surgical bypass procedures. Given the inherent morbidity and mortality associated with gastrectomy, palli... | ['Adult', 'Aged', 'Aged, 80 and over', 'Female', 'Gastrectomy', 'Humans', 'Lymph Nodes', 'Lymphatic Metastasis', 'Male', 'Middle Aged', 'Neoplasm Staging', 'Palliative Care', 'Retrospective Studies', 'Stomach Neoplasms', 'Treatment Outcome'] | 17,262,741 | [['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E04.210.419'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A10.549.400', 'A15.382.520.604.412'], ['C04.697.650.560', 'C23.550.727.650.560'], ['M01.060.116.630'], ['E01.789.625'], ['E02.760.666', 'N02.421.585.666'], ['E05.318.372.500.500.500', 'E05... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Trehalose biosynthesis is involved in sporulation of Stagonospora nodorum. | Stagonospora nodorum is a necrotrophic fungal pathogen that is the causal agent of leaf and glume blotch on wheat. S. nodorum is a polycyclic pathogen, whereby rain-splashed pycnidiospores attach to and colonise wheat tissue and subsequently sporulate again within 2-3weeks. As several cycles of infection are needed for... | ['Ascomycota', 'Biosynthetic Pathways', 'Fungal Proteins', 'Gene Deletion', 'Glucosyltransferases', 'Phylogeny', 'Plant Diseases', 'Plant Leaves', 'Sequence Homology', 'Spores, Fungal', 'Trehalose', 'Triticum', 'Virulence'] | 19,233,304 | [['B01.300.107'], ['G02.111.098', 'G03.493.100'], ['D12.776.354'], ['G05.365.590.762.320', 'G05.558.800.320'], ['D08.811.913.400.450.460'], ['G05.697', 'G16.075.605', 'L01.100.697'], ['G15.610'], ['A18.024.812'], ['G02.111.810', 'G05.810'], ['A11.870.710', 'A19.374.500', 'B05.775.710'], ['D09.698.365.900', 'D09.698.629... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Akt, a target of phosphatidylinositol 3-kinase, inhibits apoptosis in a differentiating neuronal cell line. | Phosphatidylinositol (PI) 3-kinase has been suggested to mediate cell survival. Consistent with this possibility, apoptosis of conditionally (simian virus 40 Tts) immortalized rat hippocampal H19-7 neuronal cells was increased in response to wortmannin, an inhibitor of PI 3-kinase. Downstream effectors of PI 3-kinase i... | ['Androstadienes', 'Animals', 'Apoptosis', 'Cell Differentiation', 'Cell Line', 'Culture Media, Serum-Free', 'Enzyme Activation', 'Enzyme Inhibitors', 'Genes, Dominant', 'Mutation', 'Neurons', 'Oncogene Protein v-akt', 'Phosphatidylinositol 3-Kinases', 'Phosphoinositide-3 Kinase Inhibitors', 'Protein-Serine-Threonine K... | 9,528,786 | [['D04.210.500.054.079.129'], ['B01.050'], ['G04.146.954.035'], ['G04.152'], ['A11.251.210'], ['D27.720.470.305.255', 'E07.206.255'], ['G02.111.263', 'G03.328'], ['D27.505.519.389'], ['G05.360.340.024.340.240', 'G05.420.320'], ['G05.365.590'], ['A08.675', 'A11.671'], ['D08.811.913.696.620.682.700.586', 'D12.776.624.664... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Contamination of propofol infusions in the intensive care unit: incidence and clinical significance. | Epidemics of bacteraemia and wound infection have been associated with the infusion of bacterially contaminated propofol administered during anaesthesia. We conducted an observational study to determine the incidence and clinical significance of administration of potentially contaminated propofol to patients in an ICU ... | ['APACHE', 'Anesthetics, Intravenous', 'Drug Contamination', 'Female', 'Humans', 'Incidence', 'Intensive Care Units', 'Male', 'Middle Aged', 'Observation', 'Propofol', 'Prospective Studies', 'Surgical Wound Infection', 'Syringes', 'Western Australia'] | 9,564,394 | [['E05.318.308.980.438.475.365', 'E05.318.308.980.438.475.456.500.250', 'N05.715.360.300.800.438.375.364.500.250', 'N06.850.520.308.980.438.475.364.500.250'], ['D27.505.696.277.100.035.075', 'D27.505.954.427.210.100.035.075'], ['N06.850.360'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.525.375',... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]', 'Diseases [C]', 'Geographicals [Z]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Effects of d-amphetamine and cocaine on repeated acquisition with timeout from avoidance. | The acute effects of d-amphetamine and cocaine on a repeated acquisition baseline with timeout from avoidance were investigated in two rats. Each session the animals acquired one of two different three-member response sequences. Each sequence member was associated with a different response lever. The first two correct ... | ['Animals', 'Avoidance Learning', 'Cocaine', 'Dextroamphetamine', 'Electroshock', 'Male', 'Rats', 'Time Factors'] | 733,855 | [['B01.050'], ['F02.463.425.097', 'F02.463.785.373.173'], ['D02.145.074.722.388', 'D03.132.889.354', 'D03.605.084.500.722.388', 'D03.605.869.388'], ['D02.092.471.683.152.110.200'], ['E05.723.402.403', 'F04.669.224'], ['B01.050.150.900.649.313.992.635.505.700'], ['G01.910.857']] | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Spinal pain due to metastasis of unknown origin. | A 58-year-old woman presented with non-radicular pain in the upper thorax. Due to the prolonged duration of symptoms, a bone scintigraphy was made, which showed pathological enhancement in the upper thoracic spine. An MRI demonstrated lesions of the third and fourth thoracic vertebrae. A biopsy showed a metastasis of p... | ['Antineoplastic Combined Chemotherapy Protocols', 'Biopsy, Needle', 'Combined Modality Therapy', 'Disease Progression', 'Fatal Outcome', 'Female', 'Humans', 'Immunohistochemistry', 'Low Back Pain', 'Magnetic Resonance Imaging', 'Middle Aged', 'Neoplasms, Unknown Primary', 'Positron-Emission Tomography', 'Radiotherapy,... | 15,688,189 | [['E02.183.750.500', 'E02.319.077.500', 'E02.319.310.037'], ['E01.370.225.500.384.100.119', 'E01.370.225.998.054.119', 'E01.370.388.100.100', 'E04.074.119', 'E04.665.100', 'E05.200.500.384.100.119', 'E05.200.998.054.119', 'E05.242.384.100.119'], ['E02.186'], ['C23.550.291.656'], ['E05.318.308.985.550.325', 'N01.224.935... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Named Groups [M]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 |
Blood-injury phobia with and without a history of fainting: disgust sensitivity does not explain the fainting response. | OBJECTIVE: Individuals diagnosed with blood-injury phobia respond to venipuncture with strong psychophysiological responses. We investigated whether disgust sensitivity contributes to the fainting response and is associated with parasympathetic activation, as suggested by previous research.METHODS: Twenty individuals d... | ['Adult', 'Anxiety', 'Blood', 'Emotions', 'Female', 'Humans', 'Male', 'Parasympathetic Nervous System', 'Phlebotomy', 'Phobic Disorders', 'Syncope', 'Wounds and Injuries'] | 16,554,401 | [['M01.060.116'], ['F01.470.132'], ['A12.207.152', 'A15.145'], ['F01.470'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A08.800.050.600'], ['E01.370.225.998.110.625', 'E02.800.558', 'E04.665.150.625', 'E05.200.998.110.625'], ['F03.080.725'], ['C10.597.606.358.800.600', 'C23.888.592.604.359.800.600'], ['C26']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Anatomy [A]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Four chamber right ventricular longitudinal strain versus right free wall longitudinal strain. Prognostic value in patients with left heart disease. | BACKGROUND: There is no consensus on which right ventricle (RV) strain parameter should be used in the clinical practice: four chamber RV longitudinal strain (4CH RV-LS) or free wall longitudinal strain (FWLS). The aim of this study was to analyze which RV strain parameter better predicts prognosis in patients with lef... | ['Aged', 'Echocardiography', 'Female', 'Follow-Up Studies', 'Heart Ventricles', 'Humans', 'Male', 'Prognosis', 'Prospective Studies', 'Stroke Volume', 'Ventricular Dysfunction, Left', 'Ventricular Function, Right'] | 26,711,464 | [['M01.060.116.100'], ['E01.370.350.130.750', 'E01.370.350.850.220', 'E01.370.370.380.220'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['A07.541.560'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.789'], ['E05.318.372.500.750.625', 'N05.715.360.330.500.750.650'... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Diseases [C]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Adaptive adhesion by a beetle: manipulation of liquid bridges and their breaking limits. | A drop brought into contact with a nearby substrate can wet and spread against the substrate, forming a liquid bridge that exerts a capillary force. This force due to surface tension can be used to "grab" the substrate, pulling it toward the drop. "Wet" adhesion results from the parallel action of an array of small liq... | ['Adaptation, Physiological', 'Animals', 'Chemical Phenomena', 'Coleoptera', 'Plant Leaves', 'Water'] | 24,739,008 | [['G07.025', 'G16.012.500'], ['B01.050'], ['G02'], ['B01.050.500.131.617.720.500.500.375'], ['A18.024.812'], ['D01.045.250.875', 'D01.248.497.158.459.650', 'D01.650.550.925']] | ['Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Induced niche shift as an anti-predator response for an endoparasitoid. | When two developmental stages do not share the same ecological niche, the control of the niche shift through a change in developmental timing, referred to as 'heterokairy', can provide an adaptive advantage for the individual (e.g. if mortality risk is higher in the first niche). For endoparasitic species that develop ... | ['Adaptation, Physiological', 'Animals', 'Aphids', 'Behavior, Animal', 'Diptera', 'Ecosystem', 'Feeding Behavior', 'Host-Parasite Interactions', 'Insecta', 'Larva', 'Predatory Behavior'] | 20,071,387 | [['G07.025', 'G16.012.500'], ['B01.050'], ['B01.050.500.131.617.412.165'], ['F01.145.113'], ['B01.050.500.131.617.720.500.500.750'], ['G16.500.275.157', 'N06.230.124'], ['F01.145.113.547', 'F01.145.407', 'G07.203.650.353'], ['G16.527.200.400'], ['B01.050.500.131.617'], ['B05.500.500', 'G07.345.500.550.500.500'], ['F01.... | ['Phenomena and Processes [G]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Health Care [N]'] | 0 | 1 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Bilingual young people's experiences of interpreting in primary care: a qualitative study. | BACKGROUND: Young people are often used as interpreters for family members in the primary healthcare setting.AIM: To explore bilingual young people's accounts of interpreting for family or friends in primary care settings.DESIGN OF STUDY: Qualitative study using in-depth interviews.SETTING: Community and youth groups i... | ['Adolescent', 'Child', 'Communication Barriers', 'Culture', 'Ethnic Groups', 'Family Practice', 'Female', 'Health Services Accessibility', 'Humans', 'Male', 'Multilingualism', 'Physician-Patient Relations', 'Professional-Family Relations'] | 14,694,665 | [['M01.060.057'], ['M01.060.406'], ['L01.143.230'], ['I01.076.201.450', 'I01.880.853.100'], ['M01.686.754', 'N01.224.317'], ['H02.403.340.500'], ['N04.590.374.350', 'N05.300.430'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.559.423.452'], ['F01.829.401.650.675', 'N05.300.660.625'], ['F01.829.401.550']] | ['Named Groups [M]', 'Information Science [L]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 |
Pseudo-renal failure: bladder rupture with urinary ascites. | We report a case of pseudo-renal failure caused by urinary ascites due to spontaneous bladder rupture following transurethral resection of a bladder tumour (TUR-BT). A 63-year-old man presented with 2 months of abdominal distension due to ascites. Laboratory findings showed elevated serum creatinine and hyperkalaemia. ... | ['Abdomen', 'Acute Kidney Injury', 'Ascites', 'Catheterization', 'Creatinine', 'Humans', 'Kidney', 'Male', 'Middle Aged', 'Postoperative Complications', 'Renal Dialysis', 'Renal Insufficiency', 'Rupture', 'Rupture, Spontaneous', 'Urinary Bladder', 'Urinary Bladder Neoplasms', 'Urinary Catheters'] | 26,590,189 | [['A01.923.047'], ['C12.777.419.780.050', 'C13.351.968.419.780.050'], ['C23.550.081'], ['E02.148', 'E05.157'], ['D03.383.129.308.207'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.810.453'], ['M01.060.116.630'], ['C23.550.767'], ['E02.870.300', 'E02.912.800'], ['C12.777.419.780', 'C13.351.968.419.780'], ['C2... | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Videofluoroscopy in the examination of swallowing disorders. A useful method for evaluation of rehabilitation]. | This article presents a protocol for videofluoroscopy based upon the literature and on four years of practical experience in a rehabilitation hospital from evaluation and treatment of dysphagia in patients with cerebral vascular and/or traumatic head injury. The protocol includes a description of clinical evaluation, n... | ['Brain Injuries', 'Cerebrovascular Disorders', 'Deglutition Disorders', 'Evaluation Studies as Topic', 'Fluoroscopy', 'Humans', 'Video Recording'] | 7,754,494 | [['C10.228.140.199', 'C10.900.300.087', 'C26.915.300.200'], ['C10.228.140.300', 'C14.907.253'], ['C06.405.117.119', 'C09.775.174'], ['E05.337', 'N05.715.360.335'], ['E01.370.350.700.225'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.280.960']] | ['Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Organisms [B]', 'Information Science [L]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
Tibialis anterior muscle hernia: a rationale for treatment. | Tibialis anterior muscle hernia is an orthopedic problem that should be dealt with carefully since the potential complications of treatment are serious. The literature is reviewed to provide a better understanding of the natural history, incidence, classification and treatment of muscle hernias. Guidelines are proposed... | ['Hernia', 'Humans', 'Leg', 'Muscular Diseases'] | 3,828,914 | [['C23.300.707'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A01.378.610.500'], ['C05.651', 'C10.668.491']] | ['Diseases [C]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Use of an elastic intramedullary nail in difficult humeral fractures. | Debate continues over implant selection when surgical intervention is deemed necessary in the management of diaphyseal fractures of the humerus. We present a series of patients in which we used an elastic intramedullary nail to manage a variety of difficult humeral fractures and discuss the theoretical advantages which... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Bone Nails', 'Elasticity', 'Female', 'Fracture Fixation, Intramedullary', 'Fracture Healing', 'Humans', 'Humeral Fractures', 'Male', 'Middle Aged', 'Radiography'] | 10,211,197 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E07.695.370.249', 'E07.858.442.660.460.249', 'E07.858.690.725.460.249'], ['G01.374.590'], ['E04.555.300.300.300'], ['G16.762.891.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C26.088.390', 'C26.404.500'], ['M01.060.116.630'],... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Expression of biologically active recombinant arresten in Nicotiana tabacum]. | In this report, the biological activity of the recombinant Arresten expressed in Nicotiana tabacum was studied. The gene coding for the tumor angiogenesis inhibitor Arresten was PCR-amplified from the plasmid pCA and its plant expression vector named pCAMBIAarr was constructed by inserting the Arresten cDNA fragment in... | ['Agrobacterium tumefaciens', 'Angiogenesis Inhibitors', 'Collagen Type IV', 'Genetic Vectors', 'Plants, Genetically Modified', 'Recombinant Proteins', 'Tobacco', 'Transformation, Genetic'] | 19,160,831 | [['B03.440.400.425.700.024.050', 'B03.660.050.662.024.500'], ['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'], ['D12.776.860.300.250.400.100'], ['G05.360.337'], ['B01.650.520', 'B05.620.600'], ['D12.776.828'], ['B01.650.940.800.575.912.250.908.500.900'], ['G05.728.865']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
[Decrease in tumorigenic activity of murine hepatoma cells after treatment with antioxidants and melatonin]. | We studied the effect of antioxidants such as N-acetylcysteine (NAC, 10 mM) and alpha-lipoic acid (ALA, 1.25 mM) and of the hormone melatonin (1 microM) on the ability of murine hepatoma cells MH22a to develop tumors in syngenic mice (C3HA) after subsutaneous injection. Tumor formation and development slowed down and m... | ['Acetylcysteine', 'Animals', 'Antioxidants', 'Carcinoma, Hepatocellular', 'Cell Cycle', 'Flow Cytometry', 'Humans', 'Injections, Subcutaneous', 'Liver Neoplasms', 'Melatonin', 'Mice', 'Mice, Inbred C3H', 'Thioctic Acid', 'Transplantation, Isogeneic', 'Tumor Cells, Cultured', 'Xenograft Model Antitumor Assays'] | 21,786,683 | [['D02.886.030.230.259', 'D12.125.166.230.259'], ['B01.050'], ['D27.505.519.217', 'D27.505.696.706.125', 'D27.720.799.047'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['G04.144'], ['E01.370.225.500.363.342', 'E01.370.225.500.386.350', 'E05.196.712.516.600.240.350', 'E05.2... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization and functional analysis of a tandem-repeat galectin-9 in large yellow croaker Larimichthys crocea. | Galectins are a family of endogenous lectins with â-galactosides affinity, playing significant roles in the innate immunity of vertebrates and invertebrates. In this report, a new galectin-9 cDNA was identified and characterized in large yellow croaker Larimichthys crocea (designated as LcGal-9). The complete cDNA sequ... | ['Amino Acid Sequence', 'Animals', 'Base Sequence', 'Ciliophora', 'Ciliophora Infections', 'Fish Proteins', 'Galectins', 'Gene Expression Regulation', 'Perciformes', 'Poly I-C', 'Vibrio Infections', 'Vibrio parahaemolyticus'] | 26,997,199 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['B01.043.185'], ['C01.610.752.200'], ['D12.776.325'], ['D12.776.503.307'], ['G05.308'], ['B01.050.150.900.493.602'], ['D13.695.578.550.560.600', 'D13.695.578.550.650.600'], ['C01.150.252.400.959'], ['B0... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Diseases [C]', 'Chemicals and Drugs [D]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Angiographically undetected plaque in the left main coronary artery. Findings of intravascular ultrasound imaging. | The absence of angiographic findings despite significant coronary artery disease has been previously described. Possible explanations for the limitation of plaque detection by angiography include compensatory vessel enlargement in face of intracoronary plaque formation, the lack of reference segments in diffuse atheros... | ['Aged', 'Chi-Square Distribution', 'Coronary Angiography', 'Coronary Artery Disease', 'Coronary Vessels', 'Diagnostic Errors', 'Female', 'Humans', 'Male', 'Middle Aged', 'Sensitivity and Specificity', 'Ultrasonography, Interventional'] | 9,306,143 | [['M01.060.116.100'], ['E05.318.740.994.300', 'G17.820.300', 'N05.715.360.750.750.200', 'N06.850.520.830.994.300'], ['E01.370.350.130.625', 'E01.370.350.700.060.200', 'E01.370.370.050.200', 'E01.370.370.380.200'], ['C14.280.647.250.260', 'C14.907.137.126.339', 'C14.907.585.250.260'], ['A07.015.114.269', 'A07.015.908.19... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Diseases [C]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The effect of gantry spacing resolution on plan quality in a single modulated arc optimization. | Volumetric-modulated arc technique (VMAT) is an efficient form of IMRT delivery. It is advantageous over conventional IMRT in terms of treatment delivery time. This study investigates the relation between the number of segments and plan quality in VMAT optimization for a single modulated arc. Five prostate, five lung, ... | ['Head and Neck Neoplasms', 'Humans', 'Lung Neoplasms', 'Male', 'Neoplasms', 'Prostatic Neoplasms', 'Radiotherapy Dosage', 'Radiotherapy Planning, Computer-Assisted', 'Radiotherapy, Intensity-Modulated', 'Retrospective Studies'] | 22,089,019 | [['C04.588.443'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.894.797.520', 'C08.381.540', 'C08.785.520'], ['C04'], ['C04.588.945.440.770', 'C12.294.260.750', 'C12.294.565.625', 'C12.758.409.750'], ['E02.815.639'], ['E02.950.825', 'L01.313.500.750.100.710.600.608'], ['E02.815.635.700.700', 'L01.313.500.7... | ['Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 |
A downshift in temperature activates the high osmolarity glycerol (HOG) pathway, which determines freeze tolerance in Saccharomyces cerevisiae. | The molecular mechanisms that enable yeast cells to detect and transmit cold signals and their physiological significance in the adaptive response to low temperatures are unknown. Here, we have demonstrated that the MAPK Hog1p is specifically activated in response to cold. Phosphorylation of Hog1p was dependent on Pbs2... | ['Active Transport, Cell Nucleus', 'Blotting, Northern', 'Blotting, Western', 'DNA-Binding Proteins', 'Dimethyl Sulfoxide', 'Freezing', 'Fungal Proteins', 'Glycerol', 'Intracellular Signaling Peptides and Proteins', 'Membrane Proteins', 'Microscopy, Fluorescence', 'Mitogen-Activated Protein Kinase Kinases', 'Mitogen-Ac... | 16,371,351 | [['G03.143.310.100', 'G03.143.700.100'], ['E05.196.401.095', 'E05.301.300.074', 'E05.601.100'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['D12.776.260'], ['D02.886.640.150'], ['G01.645.500', 'G01.906.595.272.437', 'G02.734.466'], ['D12.776.354'], ['D02.033.800... | ['Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
A stochastic evaluation of the decision to specialize in orthodontics. | OBJECTIVE: The objective of this paper is to identify under different scenarios, and from a financial point of view, the conditions required to successfully switch from the general dentistry practice to orthodontics.STUDY DESIGN: A mail survey was used to collect the data from the practicing orthodontists. They estimat... | ['Decision Making', 'Financial Management', 'General Practice, Dental', 'Humans', 'Income', 'Internship and Residency', 'Models, Statistical', 'Orthodontics', 'Practice Management, Dental', 'Stochastic Processes', 'Time Factors'] | 12,627,793 | [['F02.463.785.373'], ['N03.219.463'], ['H02.163.342'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.824.417'], ['I02.358.337.350.500', 'I02.358.399.350.750'], ['E05.318.740.500', 'E05.599.835', 'N05.715.360.750.530', 'N06.850.520.830.500'], ['E06.658', 'H02.163.876.439'], ['N04.452.758.708.300'], ['E05.318.7... | ['Psychiatry and Psychology [F]', 'Health Care [N]', 'Disciplines and Occupations [H]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 |
PMLRARá binds to Fas and suppresses Fas-mediated apoptosis through recruiting c-FLIP in vivo. | Defective Fas signaling leads to resistance to various anticancer therapies. Presence of potential inhibitors of Fas which could block Fas signaling can explain cancer cells resistance to apoptosis. We identified promyelocytic leukemia protein (PML) as a Fas-interacting protein using mass spectrometry analysis. The fun... | ['Animals', 'Apoptosis', 'CASP8 and FADD-Like Apoptosis Regulating Protein', 'Cells, Cultured', 'Down-Regulation', 'Female', 'HL-60 Cells', 'Humans', 'Mice', 'Mice, Inbred C57BL', 'Mice, Transgenic', 'Models, Biological', 'Oncogene Proteins, Fusion', 'Protein Binding', 'U937 Cells', 'fas Receptor'] | 21,803,845 | [['B01.050'], ['G04.146.954.035'], ['D12.644.360.024.285.024', 'D12.644.360.024.500.024', 'D12.644.360.075.421.024', 'D12.776.157.057.018.024', 'D12.776.476.075.421.024'], ['A11.251'], ['G02.111.240', 'G05.308.200', 'G07.690.773.937'], ['A11.251.210.190.465', 'A11.251.860.180.465', 'A11.627.340.360.500'], ['B01.050.150... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Optical Coherence Tomography Macular Findings after Successful Scleral Buckling in Eyes with Compromised Visual Status. | OBJECTIVE: To determine the optical coherence tomography (OCT) macular findings after successful scleral buckling in eyes with compromised visual status.STUDY DESIGN: Descriptive cross-sectional study.PLACE AND DURATION OF STUDY: Department of Clinical Ophthalmology, Khyber Institute of Ophthalmic Medical Sciences, Pos... | ['Adult', 'Aged', 'Cross-Sectional Studies', 'Female', 'Fovea Centralis', 'Humans', 'Macular Edema', 'Male', 'Middle Aged', 'Pakistan', 'Postoperative Period', 'Retinal Detachment', 'Scleral Buckling', 'Tomography, Optical Coherence', 'Treatment Outcome', 'Young Adult'] | 29,615,171 | [['M01.060.116'], ['M01.060.116.100'], ['E05.318.372.500.875', 'N05.715.360.330.500.875', 'N06.850.520.450.500.875'], ['A09.371.729.522.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C11.768.585.439.245'], ['M01.060.116.630'], ['Z01.252.245.723'], ['E04.614.750', 'N02.421.585.753.750'], ['C11.768.648'], ['E0... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Organisms [B]', 'Diseases [C]', 'Geographicals [Z]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Analysis of clinical characteristics and outcomes in patients with COVID-19 based on a series of 1000 patients treated in Spanish emergency departments. | OBJECTIVES: To describe the clinical characteristics of patients with coronavirus disease 2019 (COVID-19) treated in hospital emergency departments (EDs) in Spain, and to assess associations between characteristics and outcomes.MATERIAL AND METHODS: Prospective, multicenter, nested-cohort study. Sixty-one EDs included ... | ['Adolescent', 'Adult', 'Age Distribution', 'Age Factors', 'Aged', 'Aged, 80 and over', 'Betacoronavirus', 'COVID-19', 'Cardiovascular Diseases', 'Child', 'Child, Preschool', 'Comorbidity', 'Coronavirus Infections', 'Emergency Service, Hospital', 'Female', 'Hospital Mortality', 'Humans', 'Infant', 'Infant, Newborn', 'I... | 32,692,000 | [['M01.060.057'], ['M01.060.116'], ['I01.240.050', 'N01.224.033', 'N06.850.505.400.050'], ['N05.715.350.075', 'N06.850.490.250'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['B04.820.578.500.540.150.113'], ['C01.748.214', 'C01.748.610.763.500', 'C01.925.705.500', 'C01.925.782.600.550.200.163', 'C08.381.677.807.500',... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Geographicals [Z]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Complicated unsafe abortion in a Nigerian teaching hospital: pattern of morbidity and mortality. | Addressing unsafe abortion in developing countries may propel a rapid decline in overall maternal death. A retrospective review of patients with complicated unsafe abortion was conducted in a Nigerian Tertiary Hospital. In order to provide evidence that may inform policy changes, we describe patients' clinical profiles... | ['Abortion, Induced', 'Adolescent', 'Adult', 'Developing Countries', 'Female', 'Hospitals, Teaching', 'Humans', 'Maternal Mortality', 'Nigeria', 'Patient Safety', 'Postoperative Complications', 'Pregnancy', 'Retrospective Studies', 'Young Adult'] | 29,577,786 | [['E04.520.050'], ['M01.060.057'], ['M01.060.116'], ['I01.615.500.300'], ['N02.278.020.300', 'N02.278.421.639'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.318.308.985.550.500', 'N01.224.935.698.653', 'N06.850.505.400.975.550.500', 'N06.850.520.308.985.550.500'], ['Z01.058.290.190.565'], ['N06.850.135.060.0... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Investigation of the probable homo-dimer model of the Xeroderma pigmentosum | The Xeroderma pigmentosum complementation group A (XPA) protein functions as a primary damage verifier and as a scaffold protein in nucleotide excision repair (NER) in all higher organisms. New evidence of XPA's existence as a dimer and the redefinition of its DNA-binding domain (DBD) raises new questions regarding the... | ['Binding Sites', 'DNA, Bacterial', 'Models, Molecular', 'Molecular Dynamics Simulation', 'Protein Conformation', 'Protein Multimerization', 'Xeroderma Pigmentosum', 'Xeroderma Pigmentosum Group A Protein'] | 30,205,752 | [['G02.111.570.120'], ['D13.444.308.212'], ['E05.599.595'], ['E05.599.595.500', 'G02.111.570.895', 'L01.224.160.500'], ['G02.111.570.820.709'], ['G02.111.694'], ['C04.834.867', 'C16.131.831.936', 'C16.320.850.970', 'C17.800.600.925', 'C17.800.621.936', 'C17.800.804.936', 'C17.800.827.970', 'C18.452.284.975'], ['D12.776... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Information Science [L]', 'Diseases [C]'] | 0 | 0 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Randomized comparison of adjunctive cilostazol versus high maintenance dose clopidogrel in patients with high post-treatment platelet reactivity: results of the ACCEL-RESISTANCE (Adjunctive Cilostazol Versus High Maintenance Dose Clopidogrel in Patients With Clopidogrel Resistance) randomized study. | OBJECTIVES: The purpose of this study was to determine the impact of adjunctive cilostazol in patients with high post-treatment platelet reactivity (HPPR) undergoing coronary stenting.BACKGROUND: Although addition of cilostazol to dual antiplatelet therapy enhances adenosine diphosphate (ADP)-induced platelet inhibitio... | ['Cilostazol', 'Clopidogrel', 'Coronary Disease', 'Drug Resistance', 'Female', 'Humans', 'Male', 'Middle Aged', 'Platelet Aggregation', 'Platelet Aggregation Inhibitors', 'Prospective Studies', 'Stents', 'Tetrazoles', 'Ticlopidine'] | 19,324,253 | [['D03.383.129.617.293', 'D03.633.100.810.069'], ['D02.886.778.823.500.500', 'D03.383.725.849.500.500', 'D03.383.903.830.500.500', 'D03.633.100.928.500.500'], ['C14.280.647.250', 'C14.907.585.250'], ['G07.690.773.984'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G09.188.370.687', 'G09.188.3... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
The potential of iron chelators of the pyridoxal isonicotinoyl hydrazone class as effective antiproliferative agents. | Numerous studies have suggested that iron (Fe) chelators such as desferrioxamine (DFO) may be useful antitumor agents (Blatt and Stitely, Cancer Res 47:1749, 1987; Becton and Bryles, Cancer Res 48:7189, 1988). Recent work with several analogues of the lipophilic Fe chelator, pyridoxal isonicotinoyl hydrazone (PIH), ind... | ['Antineoplastic Agents', 'Biological Transport, Active', 'Cell Division', 'Deferoxamine', 'Gallium', 'Humans', 'Iron', 'Iron Chelating Agents', 'Isoniazid', 'Pyridoxal', 'Transferrin', 'Tumor Cells, Cultured'] | 7,492,790 | [['D27.505.954.248'], ['G03.143.310'], ['G04.144.220', 'G04.161.750.500', 'G05.113', 'G07.345.249.410.750.500'], ['D02.092.570.394.265', 'D02.241.511.372.265'], ['D01.268.556.289', 'D01.552.544.289'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D01.268.556.412', 'D01.268.956.287', 'D01.552.544.412'], ['D27.505.5... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Fecal microbiome from patients with ulcerative colitis is potent to induce inflammatory responses. | Ulcerative colitis (UC) is a chronic idiopathic disease affecting the colon. Patients with UC display a number of alterations in immune-related molecules and cells, as well as dysbiosis in the intestinal microbiota. It remains unclear whether the alterations in the patients' immune systems are initiating factors of UC ... | ['Adult', 'Colitis, Ulcerative', 'Cytokines', 'Feces', 'Female', 'Humans', 'Male', 'Microbiota', 'Middle Aged', 'Monocytes', 'Young Adult'] | 29,684,823 | [['M01.060.116'], ['C06.405.205.265.231', 'C06.405.205.731.249', 'C06.405.469.158.188.231', 'C06.405.469.432.249'], ['D12.644.276.374', 'D12.776.467.374', 'D23.529.374'], ['A12.459'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G06.591', 'G16.500.275.157.049.100.500', 'N06.230.124.049.100.500'], ['M01.060.116.63... | ['Named Groups [M]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Anatomy [A]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
No clinically significant drug interactions between lenalidomide and P‑glycoprotein substrates and inhibitors: results from controlled phase I studies in healthy volunteers. | PURPOSE: Lenalidomide, a weak substrate of P-glycoprotein (P-gp) in vitro, is an oral anticancer drug eliminated predominantly via renal excretion as unchanged compound. The role of P-gp in lenalidomide disposition and the associated clinical relevance were evaluated.METHODS: Two phase I, crossover studies were conduct... | ['ATP Binding Cassette Transporter, Subfamily B', 'Adolescent', 'Adult', 'Aged', 'Angiogenesis Inhibitors', 'Cross-Over Studies', 'Double-Blind Method', 'Drug Interactions', 'Female', 'Healthy Volunteers', 'Humans', 'Lenalidomide', 'Male', 'Middle Aged', 'Thalidomide', 'Young Adult'] | 24,659,021 | [['D12.776.157.530.100.075', 'D12.776.157.530.450.074.500.500.250', 'D12.776.395.550.020.400', 'D12.776.543.550.192.400', 'D12.776.543.585.100.200', 'D12.776.543.585.450.074.500.500.250'], ['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['D27.505.696.377.077.099', 'D27.505.696.377.450.100', 'D27.505.954.248.025'... | ['Chemicals and Drugs [D]', 'Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Phenomena and Processes [G]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Characterization of different samples of quercetin in solid-state: indication of polymorphism occurrence. | The present work was designed to compare four commercial samples of quercetin, three of them presenting pharmaceutical grade (QPGa, QPGb and QPGc) and the other one pro-analysi grade (QPA) by means of different techniques. Physical and chromatographic characterization of these samples shows different properties followi... | ['Chromatography, Liquid', 'Crystallography, X-Ray', 'Isomerism', 'Microscopy, Electron, Scanning', 'Quercetin', 'Solubility', 'Spectrophotometry, Infrared', 'Spectrophotometry, Ultraviolet'] | 17,020,162 | [['E05.196.181.400'], ['E05.196.309.742.225'], ['G02.111.570.685', 'G02.607.445'], ['E01.370.350.515.402.541', 'E05.595.402.541'], ['D03.383.663.283.266.450.284.777', 'D03.633.100.150.266.450.284.777'], ['G02.805'], ['E05.196.712.726.676', 'E05.196.867.826.676'], ['E05.196.712.726.802', 'E05.196.867.826.802']] | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Transdiaphragmatic extension of hepatic hydatid cyst. | Transdiaphragmatic extension of hydatid cyst (HC) or cystic echinococcosis (CE) of the liver is a rare phenomenon. We report a case that presented as a right middle lobe consolidation. The diagnosis of transdiaphragmatic extension of hepatic hydatid cyst was suspected on CT scan of the chest and abdomen, and confirmed ... | ['Albendazole', 'Anticestodal Agents', 'Echinococcosis, Hepatic', 'Echinococcosis, Pulmonary', 'Hemagglutination Tests', 'Humans', 'Male', 'Middle Aged', 'Pneumonectomy', 'Suction', 'Tomography, X-Ray Computed', 'Treatment Outcome'] | 12,206,480 | [['D02.241.081.251.022', 'D03.633.100.103.070'], ['D27.505.954.122.250.075.100.040'], ['C01.610.335.190.396.314', 'C01.610.518.314', 'C06.552.664.272'], ['C01.610.335.190.396.480', 'C01.610.582.314', 'C01.748.450.314', 'C08.381.517.314', 'C08.730.450.314'], ['E01.370.225.812.735.050.375', 'E05.200.812.735.050.375', 'E0... | ['Chemicals and Drugs [D]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
9-Deoxy-delta 9, delta 12-13,14-dihydroprostaglandin D2, a metabolite of prostaglandin D2 formed in human plasma. | Incubation of prostaglandin D2 (PGD2) with human plasma yielded a product that has been identified as 9-deoxy-9,10-didehydro-12,13-didehydro-13,14-dihydro-PGD2 (9-deoxy-delta 9, delta 12-13,14-dihydro-PGD2). The identification was based on mass spectrometry, UV spectrometry, mobilities and retention time on TLC and HPL... | ['Blood Proteins', 'Gas Chromatography-Mass Spectrometry', 'Humans', 'Kinetics', 'Magnetic Resonance Spectroscopy', 'Platelet Aggregation', 'Prostaglandin D2', 'Prostaglandins D'] | 6,584,883 | [['D12.776.124'], ['E05.196.181.349.500', 'E05.196.566.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G01.374.661', 'G02.111.490'], ['E05.196.867.519'], ['G09.188.370.687', 'G09.188.390.600.640'], ['D10.251.355.255.550.200.200', 'D23.469.050.175.725.200.200'], ['D10.251.355.255.550.200', 'D23.469.050.175.725... | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Calcium-dependent exocytosis in an in vitro secretory granule plasma membrane preparation from sea urchin eggs and the effects of some inhibitors of cytoskeletal function. | Egg cortical granules remain attached to the egg plasma membrane when the egg is ruptured. We present evidence that demonstrates that, when the cytoplasmic face of the egg plasma membrane is exposed to micromolar calcium concentrations, an exocytosis of the cortical granules occurs which corresponds to the cortical gra... | ['Actins', 'Animals', 'Calcimycin', 'Calcium', 'Cytoplasmic Granules', 'Cytoskeleton', 'Exocytosis', 'Female', 'Microscopy, Electron', 'Myosins', 'Ovum', 'Phenothiazines', 'Sea Urchins'] | 6,136,975 | [['D05.750.078.730.250', 'D12.776.210.500.100', 'D12.776.220.525.255'], ['B01.050'], ['D03.633.100.221.173'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.284.430.214.190.500', 'A11.284.430.214.190.875.190.190'], ['A11.284.430.214.190.750'], ['G04.468'], ['E01.370.350.515.402', 'E05.595.402'], ['D05.750... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Association Between Sulfur-Metabolizing Bacterial Communities in Stool and Risk of Distal Colorectal Cancer in Men. | BACKGROUND & AIMS: Sulfur-metabolizing microbes, which convert dietary sources of sulfur into genotoxic hydrogen sulfide (H2S), have been associated with development of colorectal cancer (CRC). We identified a dietary pattern associated with sulfur-metabolizing bacteria in stool and then investigated its association wi... | ['Aged', 'Bacteria', 'Colorectal Neoplasms', 'Diet Surveys', 'Feces', 'Feeding Behavior', 'Follow-Up Studies', 'Gastrointestinal Microbiome', 'Health Personnel', 'Humans', 'Incidence', 'Male', 'Massachusetts', 'Middle Aged', 'Prospective Studies', 'Risk Factors', 'Sulfur'] | 31,972,239 | [['M01.060.116.100'], ['B03'], ['C04.588.274.476.411.307', 'C06.301.371.411.307', 'C06.405.249.411.307', 'C06.405.469.158.356', 'C06.405.469.491.307', 'C06.405.469.860.180'], ['E05.318.308.980.485.350', 'N05.715.360.300.800.469.300', 'N06.850.505.616.300', 'N06.850.520.308.980.469.350'], ['A12.459'], ['F01.145.113.547'... | ['Named Groups [M]', 'Organisms [B]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Anatomy [A]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Geographicals [Z]', 'Chemicals and Drugs [D]'] | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Building a framework for implementing new interventions. | Implementation into real-world practice of interventions previously studied in randomized controlled trials is an ongoing challenge. In this article, we describe the methodology we used for the first phase of a project for the implementation and outcomes assessment of an occupational therapy pressure ulcer prevention i... | ['Humans', 'Occupational Therapy', 'Outcome and Process Assessment, Health Care', 'Pressure Ulcer', 'Spinal Cord Injuries'] | 25,347,759 | [['B01.050.150.900.649.313.988.400.112.400.400'], ['E02.760.169.063.500.489', 'E02.831.489', 'H02.010.500'], ['N04.761.559', 'N05.715.360.575'], ['C17.800.893.665'], ['C10.228.854.763', 'C10.900.850', 'C26.819']] | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]', 'Health Care [N]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 |
The Effect of Cortical Elasticity and Active Tension on Cell Adhesion Mechanics. | We consider a cell as an elastic, contractile shell surrounding a liquid incompressible cytoplasm and with nonspecific adhesion. We perform numerical simulations of this model to study the mechanics of cell-cell separation. By variation of parameters, we are able to recover well-known limits of the Johnson-Kendall-Robe... | ['Animals', 'Biomechanical Phenomena', 'Cell Adhesion', 'Cell Line, Tumor', 'Elasticity', 'Mice', 'Models, Biological', 'Stress, Mechanical'] | 30,773,295 | [['B01.050'], ['G01.154.090', 'G01.374.089'], ['G04.022'], ['A11.251.210.190', 'A11.251.860.180'], ['G01.374.590'], ['B01.050.150.900.649.313.992.635.505.500'], ['E05.599.395'], ['G01.374.835']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Characterization of the in vitro expressed autoimmune rippling muscle disease immunogenic domain of human titin encoded by TTN exons 248-249. | Autoimmune rippling muscle disease (ARMD) is an autoimmune neuromuscular disease associated with myasthenia gravis (MG). Past studies in our laboratory recognized a very high molecular weight skeletal muscle protein antigen identified by ARMD patient antisera as the titin isoform. These past studies used antisera from ... | ['Amino Acid Sequence', 'Autoimmune Diseases', 'Connectin', 'DNA, Complementary', 'Exons', 'Humans', 'Immunodominant Epitopes', 'Molecular Sequence Data', 'Muscle Proteins', 'Muscular Diseases', 'Protein Kinases', 'Protein Structure, Tertiary'] | 21,741,357 | [['G02.111.570.060', 'L01.453.245.667.060'], ['C20.111'], ['D08.811.913.696.620.682.324', 'D12.776.210.500.246'], ['D13.444.308.497.220', 'D13.444.600.223.500', 'D27.720.470.530.600.223.260'], ['G05.360.340.024.340.137.232'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D23.050.550.500'], ['L01.453.245.667'], ['D... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Biochemical properties of a 24 kilodalton membrane glycoprotein antigen complex from Schistosoma mansoni. | Antibodies were affinity purified from crude antiserum by elution from the 24 kDa region of preparative one-dimensional Western blots containing immobilized adult Schistosoma mansoni inner bilayer membrane proteins. They were shown to be specific for a single acidic polypeptide complex, Smgp24, following immunoblotting... | ['Animals', 'Antigens, Helminth', 'Blotting, Western', 'Chromatography, Affinity', 'Electrophoresis, Polyacrylamide Gel', 'Lectins', 'Membrane Glycoproteins', 'Schistosoma mansoni'] | 3,185,620 | [['B01.050'], ['D23.050.223'], ['E05.196.401.143', 'E05.301.300.096', 'E05.478.566.320.200', 'E05.601.262', 'E05.601.470.320.200'], ['E05.196.181.400.170'], ['E05.196.401.402', 'E05.301.300.319'], ['D12.776.503'], ['D12.776.395.550', 'D12.776.543.550'], ['B01.050.500.500.736.715.770.680.700']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
A novel method for localizing reporter fluorescent beads near the cell culture surface for traction force microscopy. | PA gels have long been used as a platform to study cell traction forces due to ease of fabrication and the ability to tune their elastic properties. When the substrate is coated with an extracellular matrix protein, cells adhere to the gel and apply forces, causing the gel to deform. The deformation depends on the cell... | ['Acrylic Resins', 'Cytological Techniques', 'Fibroblasts', 'Fluorescent Dyes', 'Gels', 'Humans', 'Microscopy, Confocal', 'Polylysine'] | 25,286,326 | [['D05.750.716.822.111', 'D25.720.716.822.111', 'J01.637.051.720.716.822.111'], ['E01.370.225.500', 'E05.200.500', 'E05.242'], ['A11.329.228'], ['D27.720.233.348', 'D27.720.470.410.505.500'], ['D20.280.320', 'D26.255.165.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E01.370.350.515.395', 'E05.595.395'], ['D... | ['Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Anatomy [A]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Quantitation of digoxigenin in serum following oral administration of digoxin in humans. | Separation of the acid breakdown products from digoxin in serum was accomplished by high performance liquid chromatography (HPLC). The major, less cardioactive, product digoxigenin was quantitated by several different commercial antisera from digoxin radioimmunoassay (RIA) kits. When two normal subjects were given digo... | ['Administration, Oral', 'Biotransformation', 'Chromatography, High Pressure Liquid', 'Digoxigenin', 'Digoxin', 'Humans', 'Male', 'Methods', 'Radioimmunoassay', 'Time Factors'] | 897,341 | [['E02.319.267.100'], ['G03.171', 'G03.787.225', 'G07.690.725.225'], ['E05.196.181.400.300'], ['D04.210.500.155.580.130.688.350'], ['D04.210.500.155.580.130.500.436', 'D04.210.500.155.580.130.688', 'D09.408.180.261.436'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['E05.581'], ['E01.370.384.700', 'E05.478.566.639... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
In vitro culture may be the major contributing factor for transgenic versus nontransgenic proteomic plant differences. | Identification of differences between genetically modified plants and their original counterparts plays a central role in risk assessment strategy. Our main goal was to better understand the relevance of transgene presence, genetic, and epigenetic changes induced by transgene insertion, and in vitro culture in putative... | ['Electrophoresis, Gel, Two-Dimensional', 'Gene Expression Regulation, Plant', 'Mass Spectrometry', 'Metabolic Networks and Pathways', 'Oryza', 'Photosynthesis', 'Plant Proteins', 'Plants, Genetically Modified', 'Proteomics', 'Stress, Physiological'] | 25,283,639 | [['E05.196.401.250', 'E05.301.300.230'], ['G05.308.375'], ['E05.196.566'], ['G03.493'], ['B01.650.940.800.575.912.250.822.616'], ['G02.111.158.937', 'G02.111.669.700', 'G02.740.921', 'G03.191.937', 'G03.493.700', 'G03.800.700', 'G15.568'], ['D12.776.765'], ['B01.650.520', 'B05.620.600'], ['H01.158.201.843', 'H01.158.27... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Chemicals and Drugs [D]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Richness of Colchic vegetation: comparison between refugia of south-western and East Asia. | BACKGROUND: The Colchis is one of the species-rich refugia and a centre of biological diversity in western Eurasia. We analysed patterns of richness, endemism and invasions in relation to taxonomy (family membership), life form, certain habitats in the Colchis, and compared them to patterns found for Japan.RESULTS: We ... | ['Biodiversity', 'Climate', 'Cycadopsida', 'Environment', 'Geography', 'Geological Phenomena', 'Geology', 'Georgia (Republic)', 'Japan', 'Magnoliopsida', 'Random Allocation', 'Russia', 'Turkey'] | 11,801,200 | [['G16.500.275.157.049', 'N06.230.124.049'], ['G16.500.275.071', 'N06.230.300.100.250'], ['B01.650.940.800.575.156'], ['G16.500.275', 'N06.230'], ['H01.277.500'], ['G01.311'], ['H01.277.562'], ['Z01.542.900.420', 'Z01.542.931.420', 'Z01.586.950.420'], ['Z01.252.474.463', 'Z01.639.595'], ['B01.650.940.800.575.912.250'],... | ['Phenomena and Processes [G]', 'Health Care [N]', 'Organisms [B]', 'Disciplines and Occupations [H]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 |
Perioperative bridging of anticoagulation: towards a more reserved approach. | BACKGROUND: Most invasive procedures require the interruption of oral anticoagulation. In 2015, an international randomised trial demonstrated that perioperative bridging caused more harm than benefit in most anticoagulated patients with atrial fibrillation, leading to a more restrictive Dutch national guideline in Apr... | ['Aged', 'Aged, 80 and over', 'Anticoagulants', 'Antifibrinolytic Agents', 'Atrial Fibrillation', 'Female', 'Guideline Adherence', 'Guidelines as Topic', 'Humans', 'Male', 'Middle Aged', 'Netherlands', 'Perioperative Care', 'Retrospective Studies', 'Thromboembolism', 'Venous Thromboembolism', 'Vitamin K'] | 31,814,575 | [['M01.060.116.100'], ['M01.060.116.100.080'], ['D27.505.954.502.119'], ['D27.505.519.421.500', 'D27.505.954.502.270.463.091'], ['C14.280.067.198', 'C23.550.073.198'], ['N04.761.337', 'N05.715.360.395'], ['N04.761.700.350', 'N05.700.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['Z01.542.... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Geographicals [Z]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 1 |
Foeniculum vulgare extract and its constituent, trans-anethole, inhibit UV-induced melanogenesis via ORAI1 channel inhibition. | BACKGROUND: Ultraviolet radiation exposure is the most important cause of extrinsic skin aging (photoaging), which causes skin wrinkling and hyperpigmentation. Although many factors are involved in the photoaging process, calcium release-activated calcium channel protein 1 (ORAI1) has been reported to be involved in UV... | ['Animals', 'Anisoles', 'Calcium', 'Cell Survival', 'Foeniculum', 'Fruit', 'HEK293 Cells', 'Humans', 'Inhibitory Concentration 50', 'Melanocytes', 'Melanoma, Experimental', 'Mice', 'Monophenol Monooxygenase', 'Neoplasm Proteins', 'ORAI1 Protein', 'Patch-Clamp Techniques', 'Plant Extracts', 'Powders', 'Stromal Interacti... | 27,712,859 | [['B01.050'], ['D02.355.601.200', 'D02.355.726.158', 'D02.455.426.559.389.657.654.158'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.346'], ['B01.650.940.800.575.912.250.075.333'], ['A18.024.500', 'G07.203.300.562', 'J02.500.562'], ['A11.251.210.172.750', 'A11.436.334'], ['B01.050.150.900.649.313.988.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Patient-controlled analgesia at the end of life at a pediatric oncology institution. | BACKGROUND: Patient controlled anesthesia (PCA) is increasingly used to manage pain in pediatric cancer patients and is important in the treatment of escalating pain at the end of life. The description of the use of opioid PCA in this population has been limited.PROCEDURE: This retrospective chart review of the last 2 ... | ['Adolescent', 'Adult', 'Analgesia, Patient-Controlled', 'Analgesics, Opioid', 'Child', 'Child, Preschool', 'Female', 'Follow-Up Studies', 'Humans', 'Infant', 'Infant, Newborn', 'Male', 'Neoplasms', 'Pain', 'Pain Management', 'Palliative Care', 'Prognosis', 'Retrospective Studies', 'Terminally Ill', 'Young Adult'] | 25,820,345 | [['M01.060.057'], ['M01.060.116'], ['E03.091.120'], ['D27.505.696.277.600.500', 'D27.505.696.663.850.014.760.500', 'D27.505.954.427.040.550.500', 'D27.505.954.427.210.600.500'], ['M01.060.406'], ['M01.060.406.448'], ['E05.318.372.500.750.249', 'N05.715.360.330.500.750.350', 'N06.850.520.450.500.750.350'], ['B01.050.150... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Health Care [N]', 'Organisms [B]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Surgical management of the hypodynamic palate. | The most successful surgical correction of velopharyngeal insufficiency (VPI) has been achieved in those patients in whom residual dynamic function of the soft palate/nasopharyngeal sphincter mechanism exists. In spite of the obvious need for rehabilitation, surgical reconstruction has often been advised against in tho... | ['Adolescent', 'Adult', 'Female', 'Humans', 'Male', 'Methods', 'Palate, Soft', 'Speech Disorders', 'Velopharyngeal Insufficiency'] | 454,288 | [] | [] | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Lipomatosis of the sciatic nerve secondary to compression by a desmoid tumor. | Lipomatosis of nerve is a rare benign tumor-like process characterized by infiltration of the epineurium by adipose and fibrous tissue leading to nerve enlargement. We describe a case of lipomatosis of the sciatic nerve compressed by an adjacent desmoid tumor. This case supports the hypothesis that lipomatosis of nerve... | ['Adult', 'Antineoplastic Agents', 'Female', 'Fibromatosis, Aggressive', 'Humans', 'Lipomatosis', 'Peripheral Nervous System Neoplasms', 'Sciatic Neuropathy', 'Treatment Outcome'] | 23,801,100 | [['M01.060.116'], ['D27.505.954.248'], ['C04.557.450.565.590.340.410'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C17.800.463', 'C18.452.584.718'], ['C04.588.614.596', 'C10.551.775', 'C10.668.829.725'], ['C10.668.829.500.675'], ['E01.789.800', 'N04.761.559.590.800', 'N05.715.360.575.575.800']] | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Intravenous amifostine during chemoradiotherapy for head-and-neck cancer: a randomized placebo-controlled phase III study. | PURPOSE: Clinical trials demonstrated the efficacy and safety of intravenous (i.v.) or subcutaneous (s.c.) amifostine for reducing xerostomia and mucositis after radiotherapy or radiochemotherapy for head-and-neck cancer. This randomized, double-blinded, placebo-controlled, phase III study evaluated the efficacy and sa... | ['Adult', 'Aged', 'Amifostine', 'Antineoplastic Agents', 'Carboplatin', 'Combined Modality Therapy', 'Disease Progression', 'Double-Blind Method', 'Female', 'Head and Neck Neoplasms', 'Humans', 'Injections, Intravenous', 'Male', 'Middle Aged', 'Radiation Injuries', 'Radiation-Protective Agents', 'Stomatitis', 'Survival... | 16,243,440 | [['M01.060.116'], ['M01.060.116.100'], ['D02.705.400.625.050', 'D02.705.539.345.050', 'D02.886.300.692.050'], ['D27.505.954.248'], ['D02.257.125'], ['E02.186'], ['C23.550.291.656'], ['E05.318.370.300', 'E05.581.500.300', 'N05.715.360.325.320', 'N06.850.520.445.300'], ['C04.588.443'], ['B01.050.150.900.649.313.988.400.1... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Removal of nitrate and phosphate using chitosan/Al2 | In the present study the chitosan/Al2O3/Fe3O4 composite nanofibrous adsorbent was prepared by electrospinning process and its application for the removal of nitrate and phosphate were compared with chitosan/Al2O3/Fe3O4 composite bead adsorbent. The influence of Al2O3/Fe3O4 composite content, pH, contact time, nitrate a... | ['Adsorption', 'Aluminum Oxide', 'Chitosan', 'Environmental Pollutants', 'Ferrosoferric Oxide', 'Hydrogen-Ion Concentration', 'Kinetics', 'Microspheres', 'Nanofibers', 'Nitrates', 'Phosphates', 'Temperature'] | 27,612,644 | [['G01.030', 'G02.020'], ['D01.056.050', 'D01.650.550.050'], ['D05.750.078.139.500', 'D09.698.211.500'], ['D27.888.284'], ['D01.490.100.375', 'D01.490.200.350', 'D01.578.285'], ['G02.300'], ['G01.374.661', 'G02.111.490'], ['E07.565'], ['J01.637.512.300'], ['D01.248.497.158.606', 'D01.625.525.550', 'D02.583'], ['D01.029... | ['Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 |
Aripiprazole salts. II. Aripiprazole perchlorate. | The molecular structure of aripiprazole perchlorate (systematic name: 4-(2,3-dichlorophenyl)-1-{4-[(2-oxo-1,2,3,4-tetrahydroquinolin-7-yl)oxy]butyl}piperazin-1-ium perchlorate), C(23)H(28)Cl(2)N(3)O(2)(+)·ClO(4)(-), does not differ substantially from the recently published structure of aripiprazole nitrate [Freire, Pol... | ['Aripiprazole', 'Crystallography, X-Ray', 'Molecular Structure', 'Perchlorates', 'Piperazines', 'Quinolones', 'Salts'] | 22,669,195 | [['D03.383.606.170', 'D03.633.100.810.835.122'], ['E05.196.309.742.225'], ['G02.111.570', 'G02.466'], ['D01.029.260.650', 'D01.210.675'], ['D03.383.606'], ['D03.633.100.810.835'], ['D01.786']] | ['Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Glucose production from cellulose through biological simultaneous enzyme production and saccharification using recombinant bacteria expressing the â-glucosidase gene. | Efficient cellulosic biomass saccharification technologies are required to meet biorefinery standards. Biological simultaneous enzyme production and saccharification (BSES), which is glucose production from cellulosic biomass by Clostridium thermocellum, can be a reliable cellulose saccharification technology for biore... | ['Bacteria', 'Cellulase', 'Cellulose', 'DNA, Recombinant', 'Gene Expression', 'Glucose', 'Hydrolysis', 'beta-Glucosidase'] | 30,237,013 | [['B03'], ['D08.811.277.450.420.200.200'], ['D05.750.078.562.180', 'D09.698.365.180', 'D25.720.099.500', 'J01.637.051.720.099.500'], ['D13.444.308.460'], ['G05.297'], ['D09.947.875.359.448'], ['G02.380'], ['D08.811.277.450.420.200.100']] | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]', 'Phenomena and Processes [G]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
Muscle interstitial fibroblasts are the main source of collagen VI synthesis in skeletal muscle: implications for congenital muscular dystrophy types Ullrich and Bethlem. | Mutations in the extracellular matrix molecule collagen VI underlie the congenital muscular dystrophy types Ullrich and Bethlem. Establishing the origin of collagen VI in muscle is important for understanding the pathophysiology of these diseases and for developing future treatment approaches involving cell-specific de... | ['Animals', 'Animals, Newborn', 'Cell Differentiation', 'Cells, Cultured', 'Coculture Techniques', 'Collagen Type VI', 'Fibroblasts', 'Gene Expression Regulation', 'Humans', 'Mice', 'Mice, Inbred C57BL', 'Microscopy, Confocal', 'Muscle, Skeletal', 'Muscular Dystrophies', 'Mutation', 'Skin'] | 18,219,255 | [['B01.050'], ['B01.050.050.282'], ['G04.152'], ['A11.251'], ['E05.481.500.374'], ['D12.776.860.300.250.400.200'], ['A11.329.228'], ['G05.308'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['B01.050.150.900.649.313.992.635.505.500'], ['B01.050.050.199.520.520.420', 'B01.050.150.900.649.313.992.635.505.500.400.420'... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Diseases [C]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
The NAM9-1 suppressor mutation in a nuclear gene encoding ribosomal mitochondrial protein of Saccharomyces cerevisiae. | The nuclear gene NAM9 from Saccharomyces cerevisiae (Sc) codes for a protein which, on the basis of sequence homology, was previously postulated to be a mitochondrial (mt) equivalent of the Escherichia coli (Ec) S4 ribosomal protein (r-protein) [Boguta et al., Mol. Cell. Biol. 12 (1992) 402-412]. The mt-r character of ... | ['Amino Acid Sequence', 'Base Sequence', 'Cell Compartmentation', 'Cell Nucleus', 'Cross Reactions', 'Fungal Proteins', 'Genes, Fungal', 'Mitochondria', 'Molecular Sequence Data', 'Mutation', 'Nuclear Proteins', 'Repressor Proteins', 'Ribosomal Proteins', 'Saccharomyces cerevisiae', 'Saccharomyces cerevisiae Proteins',... | 7,557,422 | [['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['G04.128'], ['A11.284.430.106', 'A11.284.430.214.190.875.117'], ['G12.122.281'], ['D12.776.354'], ['G05.360.340.024.340.364.500', 'G05.360.340.358.024.500', 'G05.360.340.358.365.500'], ['A11.284.430.214.190.875.564'... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Organisms [B]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Analysis of neurodevelopmental delay in children exposed in utero to hyperemesis gravidarum reveals increased reporting of autism spectrum disorder. | The purpose of this study was to follow up on the reporting of neurodevelopmental disorders in children exposed in utero to Hyperemesis Gravidarum (HG). This was an exploratory descriptive study whereby neurodevelopmental outcomes of 267 children delivered by 177 mothers with HG were compared to neurodevelopmental outc... | ['Adult', 'Autism Spectrum Disorder', 'Child', 'Female', 'Humans', 'Hyperemesis Gravidarum', 'Male', 'Neurodevelopmental Disorders', 'Pregnancy'] | 30,594,672 | [['M01.060.116'], ['F03.625.164.113'], ['M01.060.406'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C13.703.407.500', 'C23.888.821.937.049.500'], ['F03.625'], ['G08.686.784.769']] | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Diseases [C]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
[Experimental study of peanut sensitization in guinea pigs]. | An experimental study of sensitization to peanut has shown that this can be induced in guinea pigs by crushed peanuts ingested daily for three weeks although peanut oil, which is found in some preparations of vitamin D, did not sensitize the guinea pigs, when compared with a control group and a group of guinea pigs tha... | ['Administration, Oral', 'Animals', 'Arachis', 'Food Hypersensitivity', 'Guinea Pigs', 'Immunization', 'Immunoglobulin E', 'Passive Cutaneous Anaphylaxis', 'Peanut Oil', 'Plant Oils'] | 7,702,730 | [['E02.319.267.100'], ['B01.050'], ['B01.650.940.800.575.912.250.401.077'], ['C20.543.480.370'], ['B01.050.150.900.649.313.992.550'], ['E02.095.465.425.400', 'E05.478.550', 'N02.421.726.758.310', 'N06.850.780.200.425', 'N06.850.780.680.310'], ['D12.776.124.486.485.114.619.312', 'D12.776.124.790.651.114.619.312', 'D12.7... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Diseases [C]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Direct O-glycosidation of resin bound thioglycosides. | The application of the safety-catch linker concept to solid-phase glycoconjugate synthesis is described. The process allows for direct conjugation of resin bound glycans to complex aglycones during cleavage. Large excesses of either coupling partner are not required, and even very hindered alcohols serve as acceptors i... | ['Alcohols', 'Disaccharides', 'Glycosylation', 'Molecular Structure', 'Thioglycosides'] | 22,261,792 | [['D02.033'], ['D09.698.629.305', 'D09.947.750'], ['G02.111.158.812', 'G02.607.299', 'G03.191.812'], ['G02.111.570', 'G02.466'], ['D02.886.740', 'D09.408.903']] | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]'] | 0 | 0 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Prey perception of predation risk: volatile chemical cues mediate non-consumptive effects of a predator on a herbivorous insect. | Predators can affect prey in two ways-by reducing their density (consumptive effects) or by changing their behavior, physiology or other phenotypic traits (non-consumptive effects). Understanding the cues and sensory modalities prey use to detect predators is critical for predicting the strength of non-consumptive effe... | ['Animals', 'Coleoptera', 'Cues', 'Female', 'Food Chain', 'Herbivory', 'Heteroptera', 'Larva', 'Male', 'Olfactory Perception', 'Predatory Behavior', 'Risk', 'Sex Characteristics', 'Visual Perception', 'Volatile Organic Compounds'] | 25,234,373 | [['B01.050'], ['B01.050.500.131.617.720.500.500.375'], ['F02.463.425.234'], ['G16.500.275.157.250', 'N06.230.124.250'], ['F01.145.113.547.600', 'F01.145.407.758', 'G07.203.650.353.758'], ['B01.050.500.131.617.412.420'], ['B05.500.500', 'G07.345.500.550.500.500'], ['F02.463.593.485'], ['F01.145.113.111.600', 'F01.145.11... | ['Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Climate variability in early expansions of Homo sapiens in light of the new record of micromammals in Misliya Cave, Israel. | In this study, we provide the first taphonomic and taxonomic descriptions of the micromammals from Misliya Cave, where recently a Homo sapiens hemimaxilla has been reported. This finding significantly extends the time frame for the out-of-Africa presence of anatomically modern humans. It also provides an opportunity to... | ['Animals', 'Biological Evolution', 'Caves', 'Climate', 'Climate Change', 'Fossils', 'Human Migration', 'Humans', 'Israel', 'Mammals', 'Neanderthals'] | 32,062,432 | [['B01.050'], ['G05.045', 'G16.075'], ['G01.311.169', 'G16.500.275.067', 'N06.230.066'], ['G16.500.275.071', 'N06.230.300.100.250'], ['G16.500.175.374'], ['I01.076.368.584.311'], ['I01.240.600.525', 'N01.224.625.525', 'N06.850.505.400.700.525'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.375'], ... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Lenvatinib versus sorafenib in first-line treatment of patients with unresectable hepatocellular carcinoma: a randomised phase 3 non-inferiority trial. | BACKGROUND: In a phase 2 trial, lenvatinib, an inhibitor of VEGF receptors 1-3, FGF receptors 1-4, PDGF receptor á, RET, and KIT, showed activity in hepatocellular carcinoma. We aimed to compare overall survival in patients treated with lenvatinib versus sorafenib as a first-line treatment for unresectable hepatocellul... | ['Aged', 'Antineoplastic Agents', 'Carcinoma, Hepatocellular', 'Female', 'Humans', 'Liver Neoplasms', 'Male', 'Middle Aged', 'Niacinamide', 'Phenylurea Compounds', 'Quinolines', 'Sorafenib', 'Survival Rate', 'Treatment Outcome'] | 29,433,850 | [['M01.060.116.100'], ['D27.505.954.248'], ['C04.557.470.200.025.255', 'C04.588.274.623.160', 'C06.301.623.160', 'C06.552.697.160'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['C04.588.274.623', 'C06.301.623', 'C06.552.697'], ['M01.060.116.630'], ['D03.066.515.530', 'D03.383.725.547.530'], ['D02.065.950.681', 'D... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
ATP stimulation of P2X(7) receptors activates three different ionic conductances on cultured mouse Schwann cells. | Extracellular ATP, by acting on P2 purinergic receptors, is a potent mediator of cell-to-cell communication both within and between the nervous and the immune systems. We show here by patch-clamp recording, fluorescent dye uptake and immunocytochemistry that, in cultured mouse Schwann cells, ATP activates a P2X(7) rece... | ['Adenosine Triphosphate', 'Animals', 'Biotransformation', 'Calcium', 'Cells, Cultured', 'Chelating Agents', 'Culture Media', 'Egtazic Acid', 'Electrophysiology', 'Immunohistochemistry', 'Ion Channels', 'Membrane Potentials', 'Mice', 'Neuroglia', 'Neuromuscular Junction', 'Patch-Clamp Techniques', 'Potassium', 'Puriner... | 11,595,031 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['B01.050'], ['G03.171', 'G03.787.225', 'G07.690.725.225'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['A11.251'], ['D27.505.519.914.500', 'D27.720.832.500'], ['D27.720.470.305', 'E07.206'], ['D02.092.782.258.368.257', 'D02.241... | ['Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Disciplines and Occupations [H]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 0 | 0 |
Nocturnal penile erections: the diagnostic value of tumescence and rigidity activity units. | One of the most commonly used tests to distinguish psychogenic from organic erectile dysfunction (ED) is to monitor nocturnal penile tumescence using the RigiScan device and its new software called RigiScan Plus. To give a true estimate of the predictive ability of the new RigiScan software parameters, tumescence activ... | ['Adult', 'Aged', 'Algorithms', 'Erectile Dysfunction', 'Humans', 'Male', 'Middle Aged', 'Penile Erection', 'Penis', 'Predictive Value of Tests', 'Retrospective Studies', 'Sleep', 'Software', 'Young Adult'] | 19,812,580 | [['M01.060.116'], ['M01.060.116.100'], ['G17.035', 'L01.224.050'], ['C12.294.644.486', 'F03.835.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['G08.686.784.717'], ['A05.360.444.492'], ['E05.318.370.800.650', 'N05.715.360.325.700.640', 'N06.850.520.445.800.650'], ['E05.318.372.500.500.500'... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Diseases [C]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 1 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 1 | 1 | 0 |
Role of miR-34c microRNA in the late steps of spermatogenesis. | Spermatogenesis is a cyclic process in which diploid spermatogonia differentiate into haploid spermatozoa. This process is highly regulated, notably at the post-transcriptional level. MicroRNAs (miRNAs), single-stranded noncoding RNA molecules of about 20-25 nucleotides, are implicated in the regulation of many importa... | ['Animals', 'Cell Line, Tumor', 'Embryonic Stem Cells', 'HeLa Cells', 'Humans', 'Male', 'MicroRNAs', 'Oligonucleotide Array Sequence Analysis', 'RNA, Untranslated', 'Receptor, Notch2', 'Spermatogenesis', 'Transfection'] | 20,150,330 | [['B01.050'], ['A11.251.210.190', 'A11.251.860.180'], ['A11.872.700.250'], ['A11.251.210.190.400', 'A11.251.860.180.400', 'A11.436.340'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D13.150.650.319', 'D13.444.735.150.319', 'D13.444.735.790.552.500'], ['E05.393.661.640', 'E05.393.760.640', 'E05.588.570.660', 'E05... | ['Organisms [B]', 'Anatomy [A]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Study of the influencing factors of the blood levels of toxic elements in Africans from 16 countries. | Africa's economy is growing faster than any other continent and it has been estimated that the middle class in Africa now exceeds 350 million people. This has meant a parallel increase in the importation of consumer goods and in the implementation of communication and information technologies (ICT), but also in the gen... | ['Africa', 'Electronic Waste', 'Environmental Exposure', 'Environmental Pollution', 'Hazardous Substances', 'Humans', 'Income', 'Poverty', 'Recycling', 'Socioeconomic Factors', 'Spain'] | 28,734,263 | [['Z01.058'], ['N06.850.460.710.189'], ['N06.850.460.350'], ['N06.850.460'], ['D27.888.426'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N01.824.417'], ['I01.880.735.634', 'I01.880.853.996.535', 'N01.824.600'], ['N06.850.780.200.800.800.525', 'N06.850.860.510.244'], ['I01.880.853.996', 'N01.824'], ['Z01.542.846... | ['Geographicals [Z]', 'Health Care [N]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Anthropology, Education, Sociology, and Social Phenomena [I]'] | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 1 |
Brief cognitive-behavioral intervention for maternal depression and trauma in the neonatal intensive care unit: a pilot study. | Parents of hospitalized premature infants are at risk for developing psychological symptoms. This randomized controlled pilot study examined the effectiveness of a brief cognitive-behavioral intervention in reducing traumatic and depressive symptoms in mothers 1 month after their infant's discharge from the hospital. F... | ['Adult', 'Cognitive Behavioral Therapy', 'Depression', 'Female', 'Humans', 'Intensive Care Units, Neonatal', 'Mothers', 'Pilot Projects', 'Surveys and Questionnaires', 'Wounds and Injuries'] | 21,438,016 | [['M01.060.116'], ['F04.754.137.350'], ['F01.145.126.350'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['N02.278.388.493.390.380'], ['F01.829.263.500.320.200', 'I01.880.853.150.500.340.270', 'M01.620.630'], ['E05.318.372.750', 'E05.337.737', 'N05.715.360.330.720', 'N06.850.520.450.720'], ['E05.318.308.980', 'N05.... | ['Named Groups [M]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]'] | 0 | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 |
p95HER2-T cell bispecific antibody for breast cancer treatment. | T cell bispecific antibodies (TCBs) are engineered molecules that include, within a single entity, binding sites to the T cell receptor and to tumor-associated or tumor-specific antigens. The receptor tyrosine kinase HER2 is a tumor-associated antigen in ~25% of breast cancers. TCBs targeting HER2 may result in severe ... | ['Animals', 'Antibodies, Bispecific', 'Breast Neoplasms', 'CD3 Complex', 'Cell Line, Tumor', 'Cell Proliferation', 'Female', 'Humans', 'Mice', 'Receptor, ErbB-2', 'T-Lymphocytes', 'Xenograft Model Antitumor Assays'] | 30,282,693 | [['B01.050'], ['D12.776.124.486.485.114.125', 'D12.776.124.790.651.114.134', 'D12.776.377.715.548.114.134'], ['C04.588.180', 'C17.800.090.500'], ['D23.050.301.264.894.095', 'D23.101.100.894.095'], ['A11.251.210.190', 'A11.251.860.180'], ['G04.161.750', 'G07.345.249.410.750'], ['B01.050.150.900.649.313.988.400.112.400.4... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Diseases [C]', 'Anatomy [A]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
Tweet if you want to be sustainable: a thematic analysis of a Twitter chat to discuss sustainability in nurse education. | AIM: To explore the concept of sustainability in nursing using social media as a vehicle for discussion on the topic.BACKGROUND: There is a need for an increased awareness among nurses of the issues that are crucial for the healthcare sector to prepare for climate change and contribute to sustainable development. Howev... | ['Climate Change', 'Conservation of Natural Resources', 'Curriculum', 'Education, Nursing', 'Europe', 'Humans', 'Internet', 'Nurses', 'Qualitative Research', 'Social Media'] | 26,821,875 | [['G16.500.175.374'], ['J01.256', 'N06.230.080'], ['I02.158'], ['I02.358.462'], ['Z01.542'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.230.110.500'], ['M01.526.485.650', 'N02.360.650'], ['H01.770.644.241.850'], ['L01.178.751', 'L01.224.230.110.500.750']] | ['Phenomena and Processes [G]', 'Technology, Industry, and Agriculture [J]', 'Health Care [N]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Geographicals [Z]', 'Organisms [B]', 'Information Science [L]', 'Named Groups [M]', 'Disciplines and Occupations [H]'] | 0 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 1 | 1 |
ATP hydrolysis catalyzed by human replication factor C requires participation of multiple subunits. | Human replication factor C (hRFC) is a five-subunit protein complex (p140, p40, p38, p37, and p36) that acts to catalytically load proliferating cell nuclear antigen onto DNA, where it recruits DNA polymerase delta or epsilon to the primer terminus at the expense of ATP, leading to processive DNA synthesis. We have pre... | ['Adenosine Triphosphate', 'Amino Acid Sequence', 'Binding Sites', 'DNA', 'DNA Replication', 'DNA-Binding Proteins', 'Homeodomain Proteins', 'Humans', 'Hydrolysis', 'In Vitro Techniques', 'Minor Histocompatibility Antigens', 'Models, Biological', 'Mutagenesis, Site-Directed', 'Point Mutation', 'Proliferating Cell Nucle... | 9,751,713 | [['D03.633.100.759.646.138.236', 'D13.695.667.138.236', 'D13.695.827.068.236'], ['G02.111.570.060', 'L01.453.245.667.060'], ['G02.111.570.120'], ['D13.444.308'], ['G02.111.225', 'G05.226'], ['D12.776.260'], ['D12.776.260.400'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G02.380'], ['E05.481'], ['D23.050.301.500... | ['Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Oligodendroglial lineage cells express neuroligand receptors. | This study was designed to determine whether cells of the oligodendroglial lineage express neuroligand receptors linked to Ca2+ mobilization. Intracellular Ca2+ levels were monitored with a video-based imaging system and cells were characterized with immunocytochemical markers. O-2A progenitor cells (A2B5+/GFAP-) and m... | ['Animals', 'Animals, Newborn', 'Biomarkers', 'Calcium', 'Cell Differentiation', 'Cells, Cultured', 'Cerebral Cortex', 'Image Processing, Computer-Assisted', 'Neuropeptides', 'Neurotransmitter Agents', 'Oligodendroglia', 'Rats', 'Receptors, Neurotransmitter', 'Signal Transduction', 'Stem Cells', 'Videotape Recording'] | 8,104,891 | [['B01.050'], ['B01.050.050.282'], ['D23.101'], ['D01.268.552.100', 'D01.552.539.288', 'D23.119.100'], ['G04.152'], ['A11.251'], ['A08.186.211.200.885.287.500'], ['L01.224.308'], ['D12.644.400', 'D12.776.631.650'], ['D27.505.519.625', 'D27.505.696.577'], ['A08.637.600', 'A11.650.600'], ['B01.050.150.900.649.313.992.635... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Information Science [L]', 'Technology, Industry, and Agriculture [J]'] | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
A bacterial one-hybrid system for determining the DNA-binding specificity of transcription factors. | The DNA-binding specificities of transcription factors can be used to computationally predict cis-regulatory modules (CRMs) that regulate gene expression. However, the absence of specificity data for the majority of transcription factors limits the widespread implementation of this approach. We have developed a bacteri... | ['Animals', 'Binding Sites', 'DNA, Bacterial', 'Drosophila Proteins', 'Drosophila melanogaster', 'Escherichia coli', 'Genes, Regulator', 'Protein Binding', 'Protein Interaction Mapping', 'Sensitivity and Specificity', 'Sequence Analysis', 'Transcription Factors', 'Two-Hybrid System Techniques'] | 16,041,365 | [['B01.050'], ['G02.111.570.120'], ['D13.444.308.212'], ['D12.776.093.500.462'], ['B01.050.500.131.617.720.500.500.750.310.250.500'], ['B03.440.450.425.325.300', 'B03.660.250.150.180.100'], ['G05.360.340.024.340.425'], ['G02.111.679', 'G03.808'], ['E05.601.690'], ['E05.318.370.800', 'E05.318.740.872', 'G17.800', 'N05.7... | ['Organisms [B]', 'Phenomena and Processes [G]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]'] | 0 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 1 | 0 |
Hepatitis B carriers in large vehicle drivers of Iran. | Hepatitis B is a serious cause of mortality and morbidity worldwide. The prevalence of hepatitis B surface antigen in Iran is about 1.7% but little is known about the high-risk occupations. This study was conducted to investigate the prevalence of HBsAg and assess risk factors of infection in Iran's large vehicle drive... | ['Adult', 'Automobile Driving', 'Blood Transfusion', 'Carrier State', 'Hepatitis B', 'Hepatitis B Surface Antigens', 'Humans', 'Iran', 'Male', 'Middle Aged', 'Prevalence', 'Risk Factors', 'Smoking', 'Socioeconomic Factors', 'Tattooing'] | 12,706,681 | [['M01.060.116'], ['I03.125'], ['E02.095.135'], ['N06.850.520.169'], ['C01.221.250.500', 'C01.925.256.430.400', 'C01.925.440.435', 'C06.552.380.705.437'], ['D23.050.327.495.500.475'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['Z01.252.245.500.350'], ['M01.060.116.630'], ['E05.318.308.985.525.750', 'N01.224.935.... | ['Named Groups [M]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Health Care [N]', 'Diseases [C]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Geographicals [Z]', 'Psychiatry and Psychology [F]'] | 0 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 1 | 0 | 0 | 1 | 1 | 1 |
Ion-selective electrodes with unusual response functions: simultaneous formation of ionophore-primary ion complexes with different stoichiometries. | It is well known that the selectivity of an ion-selective electrode (ISE) depends on the stoichiometry of the complexes between its ionophore and the target and interfering ions. It is all the more surprising that the possibility for the simultaneous occurrence of multiple target ion complexes with different complex st... | ['Electrochemistry', 'Ion-Selective Electrodes', 'Ionophores', 'Membranes, Artificial', 'Potentiometry'] | 22,128,799 | [['H01.181.529.307'], ['E07.305.250.471'], ['D27.505.519.562.374', 'D27.720.395'], ['D25.479', 'J01.637.051.479', 'J01.637.087.500'], ['E05.196.922.750', 'E05.301.710']] | ['Disciplines and Occupations [H]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Technology, Industry, and Agriculture [J]'] | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 0 | 0 | 0 |
The effects of smoking on ovarian function and fertility during assisted reproduction cycles. | OBJECTIVE: To investigate the effects of cigarette smoking on ovarian function and fertility in women undergoing assisted reproduction cycles.METHODS: We assessed the effects of smoking on ovarian function and fertility in a cohort of 499 women. Questionnaires were designed to quantify past smoking exposure and to dete... | ['Adult', 'Female', 'Fertility', 'Fertilization in Vitro', 'Gamete Intrafallopian Transfer', 'Humans', 'Ovary', 'Pregnancy', 'Pregnancy Rate', 'Reproductive Techniques', 'Smoking', 'Zygote Intrafallopian Transfer'] | 8,885,914 | [['M01.060.116'], ['G08.686.210'], ['E02.875.800.750', 'E05.820.800.750'], ['E02.875.800.875', 'E05.820.800.875'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['A05.360.319.114.630', 'A05.360.576.497', 'A06.300.312.497'], ['G08.686.784.769'], ['E05.318.308.985.775', 'G08.686.705', 'N01.224.935.849', 'N06.850.505.4... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Anatomy [A]', 'Health Care [N]', 'Psychiatry and Psychology [F]'] | 1 | 1 | 0 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
A prospective, naturalistic, blinded study of early neurobehavioral outcomes for infants following prenatal antidepressant exposure. | OBJECTIVE: This study examined the potential effects of antidepressant exposure in pregnancy on early infant neurobehavioral outcomes.METHOD: In this prospective, naturalistic study, neurobehavioral assessments using the Brazelton Neonatal Behavioral Assessment Scale (BNBAS) were completed by blinded raters between Mar... | ['Adult', 'Antidepressive Agents', 'Child Development', 'Depressive Disorder, Major', 'Female', 'Humans', 'Infant', 'Infant Behavior', 'Infant, Newborn', 'Male', 'Neurologic Examination', 'Pregnancy', 'Pregnancy Complications', 'Prenatal Exposure Delayed Effects', 'Prospective Studies', 'Reference Values', 'Risk Factor... | 21,672,498 | [['M01.060.116'], ['D27.505.954.427.700.122'], ['F01.525.200', 'G07.345.374.750'], ['F03.600.300.375'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703'], ['F01.145.179.500'], ['M01.060.703.520'], ['E01.370.376.550', 'E01.370.600.550'], ['G08.686.784.769'], ['C13.703'], ['C13.703.824.500'], ['E05.318.372... | ['Named Groups [M]', 'Chemicals and Drugs [D]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Differential roles of viral RNA and cRNA in functional modulation of the influenza virus RNA polymerase. | The RNA-dependent RNA polymerase of influenza virus is composed of three viral P proteins (PB1, PB2, and PA) and involved in both transcription and replication of the RNA genome. For the molecular anatomy of this multifunctional enzyme, we have established a simultaneous expression of three P proteins in cultured insec... | ['Baculoviridae', 'Base Sequence', 'DNA-Directed RNA Polymerases', 'Molecular Sequence Data', 'Orthomyxoviridae', 'Poly A', 'RNA, Complementary', 'RNA, Viral'] | 11,373,286 | [['B04.280.065', 'B04.525.100'], ['G02.111.570.080', 'G05.360.080', 'L01.453.245.667.080'], ['D08.811.913.696.445.735.270'], ['L01.453.245.667'], ['B04.820.480.968'], ['D13.695.578.550.500'], ['D13.444.600.723.480', 'D13.444.735.480', 'D27.720.470.530.600.825.840'], ['D13.444.735.828']] | ['Organisms [B]', 'Phenomena and Processes [G]', 'Information Science [L]', 'Chemicals and Drugs [D]'] | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Brain structure, cognition and negative symptoms in schizophrenia are associated with serum levels of polysialic acid-modified NCAM. | The neural cell adhesion molecule (NCAM) is a glycoprotein implicated in cell-cell adhesion, neurite outgrowth and synaptic plasticity. Polysialic acid (polySia) is mainly attached to NCAM (polySia-NCAM) and has an essential role in regulating NCAM-dependent developmental processes that require plasticity, that is, cel... | ['Adult', 'Brain', 'Brain Mapping', 'Cell Movement', 'Cognition Disorders', 'Diffusion Tensor Imaging', 'Female', 'Humans', 'Male', 'Neural Cell Adhesion Molecules', 'Neuronal Plasticity', 'Organ Size', 'Schizophrenia', 'Sialic Acids'] | 26,460,482 | [['M01.060.116'], ['A08.186.211'], ['E01.370.350.578.875.500', 'E01.370.376.537.625.500', 'E05.629.875.500'], ['G04.198', 'G07.568.500.180'], ['F03.615.250'], ['E01.370.350.578.750', 'E01.370.350.825.500.150.500', 'E01.370.376.537.500', 'E05.629.750'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['D12.776.395.550.... | ['Named Groups [M]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Psychiatry and Psychology [F]', 'Organisms [B]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Translation of random painful stimuli into numerical responses in fibromyalgia and perioperative patients. | Number-based assessment tools are used to evaluate pain perception in patients and determine the effect of pain management. The aim of this study was to determine the ability of chronic and acute pain patients to score their response to randomly applied noxious stimuli and assess the effect of opioid treatment. Thirty-... | ['Adolescent', 'Adult', 'Aged', 'Aged, 80 and over', 'Electric Stimulation', 'Female', 'Fibromyalgia', 'Humans', 'Male', 'Middle Aged', 'Pain Measurement', 'Pain Threshold', 'Pain, Postoperative', 'Severity of Illness Index', 'Young Adult'] | 26,307,857 | [['M01.060.057'], ['M01.060.116'], ['M01.060.116.100'], ['M01.060.116.100.080'], ['E05.723.402'], ['C05.651.324', 'C05.799.321', 'C10.668.491.425'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.116.630'], ['E01.370.600.550.324'], ['F02.463.593.710.560', 'F02.830.816.444.700', 'G11.561.790.444.700'], ['C23... | ['Named Groups [M]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Organisms [B]', 'Psychiatry and Psychology [F]', 'Phenomena and Processes [G]', 'Health Care [N]'] | 0 | 1 | 1 | 0 | 1 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 |
Cerebrovascular Hemodynamics During the Practice of Bhramari Pranayama, Kapalbhati and Bahir-Kumbhaka: An Exploratory Study. | Various pranayama techniques are known to produce different physiological effects. We evaluated the effect of three-different pranayama techniques on cerebrovascular hemodynamics. Eighteen healthy volunteers with the mean ± standard deviation age of 23.78 ± 2.96 years were performed three-different pranayama techniques... | ['Adult', 'Cerebrovascular Circulation', 'Exercise', 'Female', 'Hemodynamics', 'Humans', 'Male', 'Respiration', 'Ultrasonography, Doppler, Transcranial', 'Yoga', 'Young Adult'] | 29,188,396 | [['M01.060.116'], ['G09.330.100.159'], ['G11.427.410.698.277', 'I03.350'], ['G09.330.380'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G09.772.705'], ['E01.370.350.578.937.260.850', 'E01.370.350.700.560.260.850', 'E01.370.350.850.260.850', 'E01.370.350.850.850.870', 'E01.370.376.537.750.260.850', 'E05.629.937.2... | ['Named Groups [M]', 'Phenomena and Processes [G]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Humanities [K]'] | 0 | 1 | 0 | 0 | 1 | 0 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 |
High content analysis assay for prediction of human hepatotoxicity in HepaRG and HepG2 cells. | Drug-induced liver injury (DILI) results in the termination of drug development or withdrawal of a drug from the market. The establishment of a predictive, high-throughput preclinical test system to evaluate potential clinical DILI is therefore required. Here, we established a high content analysis (HCA) assay in human... | ['Cell Line', 'Chemical and Drug Induced Liver Injury', 'Drug Evaluation, Preclinical', 'Glutathione', 'Hep G2 Cells', 'Humans', 'Membrane Potential, Mitochondrial', 'Reactive Oxygen Species'] | 26,921,665 | [['A11.251.210'], ['C06.552.100', 'C25.100.562', 'C25.723.260'], ['E05.290.750', 'E05.337.550'], ['D12.644.456.448'], ['A11.251.860.180.432', 'A11.436.348.500'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['G03.295.770.500', 'G04.580.550', 'G07.265.675.550'], ['D01.339.431', 'D01.650.775']] | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Phenomena and Processes [G]'] | 1 | 1 | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 0 |
IQGAPs are differentially expressed and regulated in polarized gastric epithelial cells. | IQGAPs, GTPase-activating proteins with an IQ motif, are thought to regulate many actin cytoskeleton-based activities through interactions with Cdc42 and Rac. Recently, Cdc42 was implicated in regulation of gastric parietal cell HCl secretion, and IQGAP2 was immunolocalized with Cdc42 to F-actin-rich intracellular cana... | ['Amino Acid Sequence', 'Animals', 'Cells, Cultured', 'Epithelial Cells', 'Gastric Mucosa', 'Gene Expression', 'Gene Expression Regulation', 'Molecular Sequence Data', 'Parietal Cells, Gastric', 'Phosphorylation', 'Rabbits', 'Sequence Alignment', 'Sequence Homology, Amino Acid', 'Signal Transduction', 'Subcellular Frac... | 15,458,922 | [['G02.111.570.060', 'L01.453.245.667.060'], ['B01.050'], ['A11.251'], ['A11.436'], ['A03.556.875.875.440', 'A10.615.550.291'], ['G05.297'], ['G05.308'], ['L01.453.245.667'], ['A03.556.875.875.440.708', 'A10.615.550.291.650', 'A11.436.708'], ['G02.111.665', 'G02.607.780', 'G03.796'], ['B01.050.150.900.649.313.968.700']... | ['Phenomena and Processes [G]', 'Information Science [L]', 'Organisms [B]', 'Anatomy [A]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 |
Bioreactor cultivation of anatomically shaped human bone grafts. | In this chapter, we describe a method for engineering bone grafts in vitro with the specific geometry of the temporomandibular joint (TMJ) condyle. The anatomical geometry of the bone grafts was segmented from computed tomography (CT) scans, converted to G-code, and used to machine decellularized trabecular bone scaffo... | ['Bioreactors', 'Bone Transplantation', 'Dimethylpolysiloxanes', 'Equipment Design', 'Humans', 'Image Processing, Computer-Assisted', 'Temporomandibular Joint', 'Tissue Engineering', 'Tissue Scaffolds', 'Tomography, X-Ray Computed'] | 24,014,312 | [['E07.115', 'J01.897.120.115'], ['E02.095.147.725.052', 'E04.555.130', 'E04.936.580.052'], ['D02.756.650.700.150', 'D05.750.900.850.150', 'D25.720.900.850.150', 'J01.637.051.720.900.850.150'], ['E05.320'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['L01.224.308'], ['A02.835.583.861', 'A14.907'], ['E05.481.500.3... | ['Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]', 'Organisms [B]', 'Information Science [L]', 'Anatomy [A]'] | 1 | 1 | 0 | 1 | 1 | 0 | 0 | 0 | 0 | 1 | 1 | 0 | 0 | 0 |
Congestive heart failure and absent femoral pulses in newborns without coarctation of the aorta. | Two infants with thrombosis of the abdominal aorta are discussed. In each case the presentation was indistinguishable from that in coarctation of the aorta, with heart failure and absent femoral pulses. Surgery in one infant successfully relieved the obstruction. The diagnosis may not be suspected from the history. Agg... | ['Aorta, Abdominal', 'Aortic Coarctation', 'Aortic Diseases', 'Diagnosis, Differential', 'Heart Failure', 'Humans', 'Infant, Newborn', 'Infant, Newborn, Diseases', 'Male', 'Thrombosis'] | 6,831,958 | [['A07.015.114.056.205'], ['C14.240.400.090', 'C14.280.400.090', 'C16.131.240.400.090'], ['C14.907.109'], ['E01.171'], ['C14.280.434'], ['B01.050.150.900.649.313.988.400.112.400.400'], ['M01.060.703.520'], ['C16.614'], ['C14.907.355.830']] | ['Anatomy [A]', 'Diseases [C]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Organisms [B]', 'Named Groups [M]'] | 1 | 1 | 1 | 0 | 1 | 0 | 0 | 0 | 0 | 0 | 0 | 1 | 0 | 0 |
Paraquat concentration and renal function in mice fed purified and cereal-based diets. | Paraquat, a broad spectrum herbicide, has differential effects in mice depending upon whether a purified or a cereal-based diet is fed. Male ICR mice were fed either a cereal-based closed-formula diet or a purified diet for 7-14 days. After intraperitoneal injection, radiolabeled paraquat was measured in blood, lung, k... | ['Animals', 'Blood Urea Nitrogen', 'Diet', 'Edible Grain', 'Food, Formulated', 'Hematocrit', 'Ions', 'Kidney', 'Kinetics', 'Male', 'Mice', 'Mice, Inbred ICR', 'Paraquat'] | 6,678,755 | [['B01.050'], ['E01.370.225.124.100.115', 'E01.370.390.400.100', 'E05.200.124.100.115'], ['G07.203.650.240'], ['A18.024.500.750.500', 'B01.650.160.250', 'B01.650.510.250', 'G07.203.300.300.550', 'G07.203.300.775.500', 'J02.500.300.550', 'J02.500.775.500'], ['G07.203.300.525.350', 'J02.500.525.350'], ['E01.370.225.625.4... | ['Organisms [B]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Phenomena and Processes [G]', 'Anatomy [A]', 'Technology, Industry, and Agriculture [J]', 'Chemicals and Drugs [D]'] | 1 | 1 | 0 | 1 | 1 | 0 | 1 | 0 | 0 | 1 | 0 | 0 | 0 | 0 |
[Diagnosis and therapy of a dog with an atypical eosinophilic cellulitis]. | A 6 years old female bernese mountain dog was seen for a nodular and erythemato-edematous dermatosis resistant to therapy. The histopathological exam showed a eosinophilic cellulitis with flame figures, which are caracteristic for the Wells' syndrome in human. A combined treatment with marbofloxacin and prednisolone br... | ['Animals', 'Anti-Bacterial Agents', 'Anti-Infective Agents', 'Biopsy', 'Cellulitis', 'Dapsone', 'Dermatitis', 'Dogs', 'Eosinophilia', 'Euthanasia', 'Female', 'Fluoroquinolones', 'Humans', 'Prednisolone', 'Skin Ulcer'] | 21,043,027 | [['B01.050'], ['D27.505.954.122.085'], ['D27.505.954.122'], ['E01.370.225.500.384.100', 'E01.370.225.998.054', 'E01.370.388.100', 'E04.074', 'E05.200.500.384.100', 'E05.200.998.054', 'E05.242.384.100'], ['C01.800.130', 'C01.830.200', 'C17.300.185', 'C23.550.470.756.200'], ['D02.886.590.263'], ['C17.800.174'], ['B01.050... | ['Organisms [B]', 'Chemicals and Drugs [D]', 'Analytical, Diagnostic and Therapeutic Techniques, and Equipment [E]', 'Diseases [C]', 'Anthropology, Education, Sociology, and Social Phenomena [I]', 'Health Care [N]'] | 0 | 1 | 1 | 1 | 1 | 0 | 0 | 0 | 1 | 0 | 0 | 0 | 1 | 0 |
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