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Transit time is the time required for the basal cells to reach uppermost part of epidermis,which is 4 weeks.It is decreased in psoriasis.
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The patient has PMR. A relatively common disease of the elderly, PMR presents as morning stiffness and pain in the shoulders, neck, and hip girdle. Diagnosis is mainly clinical; improvement of symptoms throughout the day and an absence of joint findings on physical examination provide clues to the diagnosis. Most patie...
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Typhoid fever Clinical features are outlined in Box 11.42. The incubation period is typically about 10-14 days but can be longer, and the onset may be insidious. The temperature rises in a stepladder fashion for 4 or 5 days with malaise, increasing headache, drowsiness and aching in the limbs. Constipation may be cause...
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Ans. is 'a' i.e., First trimester of pregnancy In general, the earlier in pregnancy infection occurs, the greater the damage to the fetus. Maximum damage to the fetus occurs when infection is acquired in the first trimester of pregnancy.
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HPV 11 related Recurrent respiratory papillomatosis is more aggressive than HPV 6 mediated disease is suppoed by the clinical evidence. HPV 11 does demonstrate a greater probability of producing malignant changes also.
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Barr body, or X chromatin Inactive X can be seen in the interphase nucleus as a darkly staining small mass in contact with the nuclear membrane known as the. Number of Barr bodies = number of X chromosome -1 , Turner syndrome patients, number of Barr body = 1-1=0.
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Pure gold is the noblest of all dental metals, rarely tarnishing or corroding in the oral cavity. It is inactive chemically, and it is not affected by air, heat, moisture, or most solvents. At room temperature, two thin sheets of atomically clean pure gold can be welded under  pressure. The  procedure  is  also called ...
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Methods used for various studies: - 1. Bohr's method: - Physiological dead space 2. Fowler's method: - Anatomic dead space. Based on single breath nitrogen analysis technique. A person is given 100% oxygen in single breaths, that breath enters alveoli Now the person stas exhaling out, the first air that comes out, it h...
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Ans. is 'a' i.e., Yellow fever; 'b' i.e., Dengue; 'c' i.e.. Chikungunva fever
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Dysgerminoma: It is the most common pure germ cell tumor of ovary. Its solid, firm and non-cystic (solid tumor of young – first differential is dysgerminoma) It corresponds to Seminoma. It is common under the age of 20. It is usually unilateral. It is neutral. It secrets placental alkaline phosphatase. It may be assoc...
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HGP is a transferase that catalyzes the conversion of hypoxanthine to inosine monophosphate and guanine to guanosine monophosphate. This reaction transfers the 5-phosphoribosyl group from 5-phosphoribosyl 1-pyrophosphate (PRPP) to the purine. HGP plays a central role in the generation of purine nucleotides through the ...
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Sphincter of oddi dysfunction Pain similar to biliary colic with normal LFT and episodes of acute pancreatitis have been attributed to a poorly defined syndrome known as sphincter of oddi dysfunction The pathogenesis is unclear. Postulated theories include gallstone migration inducing fibrosis of the sphincter, trauma,...
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In children, ITP is the most common form of thrombocytopenic purpura. In most cases, a preceding viral infection can be noted. No diagnostic test identifies this disease; exclusion of the other diseases listed in the question is necessary. In this disease, the platelet count is frequently less than 20,000/mL, but other...
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Ans. is 'b' i.e. illusion o Altered perception of real object (i.e presence of external stimulus) - Illusiono False perception without external stimulus - Hallucination.# Here in this question external stimulus is present in the form of man shaped window cover. So it is an example of illusion.o A delusion is a disorder...
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Ursodeoxycholic acid (10-15 mg/kg/day) is the drug of choice in the treatment of intrahepatic cholestasis in pregnancy. It relieves pruritus, reduces bile salt levels in maternal serum and may reduce the frequency of fetal complications. It improves serum liver test and liver histology in cholestatic disease. Ref: Oxfo...
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Ans. is `c' i.e., Thyroplasty type III Puberphonia (Mutational falset to voice) In males at the time of pubey, the voice normally drops by an octave and becomes low pitch. It occurs because vocal cords lengthen. Failure of this change leads to persistence of childhood high pitched voice and is called as puberphonia. It...
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Ans. is 'a' i.e., Safflower oil
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70
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Minocycline This is the most lipid-soluble of the tetracyclines and inhibits bacterial protein synthesis. In clinical trials, the clearance of ble M.leprae from the skin by minocycline was faster than that repoed from dapsone or clofazimine and similar to that for ofloxacin. Minocycline may strengthen MDT, for multibac...
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Ans. C: Squamous Cell Carcinoma Cervical cancer is typically composed of squamous cells. The most impoant risk factor in the development of cervical cancer is infection with a high-risk strain of Human papilloma virus. Women who have many sexual paners (or who have sex with men or women who had many paners) have a grea...
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Ans. is 'c' i.e., Rhodamine Fluorescent microscopy helps to provide rapid diagnosis. When ceain dyes are exposed to ultraviolet light, they absorb energy and emit visible light, i.e. they fluoresce. Tissue or organisms stained with such a dye and examined with U.V. light in a specially adapted microscope are seen as fl...
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Obsessive compulsive disorder (OCD) is characterized by recurrent, irresistible, intrusive, irrelevant and EGO DYSTONIC thoughts. They present with CONTAMINATION OBSESSIONS- WASHING COMPULSIONS PATHOLOGICAL DOUBT OBSESSIONS- CHECKING COMPULSIONS Patients may present with repeated doubts of wheather they have locked the...
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Ans. is 'a' i.e., Thalassemiao Thalassemia is defined as a Quantitative defect in synthesis of structurally normal elobin chains.Sickle Cell Disease represents a qualitative defect in synthesis of globin chains (Structurally abnormal globin chains).# G6PD Deficiency and Diamond-Blackfan Syndrome (Pure Red Cell Aplasia)...
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D i.e. Ribonuclease
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Smears stained with methylene blue or one of the special stains(Neisser's or Albe's )will show the bacilli with metachromatic granules. Albes stain may show delicate green bacilli with purple-blue metachromatic granules. For culture, the swabs are inoculated on Loeffler's serum slope, tellurite blood agar and a plate o...
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Ans. is 'a' i.e., Vibrio VIBRIO CHOI.ERAEo MorphologyGram negativeBacilliNon capsulatedComma shapedS-shaped or spiral form may be seen.Arranged in parallel rows - Fish in stream appearanceMotile by polar flegellum - Darting type motility.Actively motile vibrios suggest a 'Swarm of gnats'o Culture characteristicStrongly...
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The pathophysiology of acute respiratory distress syndrome involves fluid accumulation in the lungs not explained by hea failure (noncardiogenic pulmonary edema). Of these, the pathology most associated with ARDS is DAD, which is characterized by a diffuse inflammation of lung tissue. Ref Harrison20th edition pg 1059
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Budd Chiari syndrome may be predisposed by hypercoagulable conditions, eg deficiency of antithrombin, protein C & S. Clinical features The acute syndrome presents with rapidly progressive - severe upper abdominal pain, jaundice, hepatomegaly (enlarge liver), ascites, elevated liver enzymes and eventual encephalopathy. ...
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RDA in pregnancy Energy → +350 kcal/d iron → 35 mg/d Folic acid → 500 ug/d Magnesium → 310 mg/d Iodine → 250 µg/d
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The side effects of oral pills are: a. Weight gain, acne, chloasma. Other serious complications are: b. Venous thromboembolism, pulmonary thrombosis. c. Coronary and cerebral thrombosis resulting in myocardial infarction or stroke. The estrogen component of the OC has been mainly held responsible for the venous thrombo...
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Post maturity
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EUS- Most sensitive method to detect ampullary stones
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Ans: C (Arise from C8 nerve root) "The trigeminal nerve through its three branches is the chief sensory' nerve of the faceJr>- B.D.C 4th/ VoS HI 54"The trigeminal nerve emerges near the midpontine level. It has small motor root & large sensory root?'- Gray's 40th/284 SpinaI nucleus of trigeminal nerve extends from uppe...
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Bence Jones proteins are made up of light chain consisting of either kappa or lambda light chains and also para proteins in the serum Reference textbook of Pathology 6th edition Author Harsha Mohan page number 383
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Compomer is a polyacid-modified composite made by incorporating glass particles of GIC in water-free polyacid liquid monomer with appropriate initiator.  The rationale for using this material is the integration of the fluoride-releasing capability of glass ionomers with the durability of resin composites.  Compomers poss...
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Painless haematuria is by far the most common symptom and should be regarded as indicative of a bladder carcinoma untill proven otherwise." MC primary tumor which gives secondary to penis - bladder carcinoma Commonest tumor of Urinary bladder - transitional cell Ca Commonest tumor of U.B. in a child - rhabdomyosarcoma ...
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Sphincter urethrae muscle is a part of deep perineal space.
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Ans. is 'b' i.e., Vulva * The sentinel lymph node is the hypothetical first lymph node or group of nodes reached by metastasizing cancer cells from a primary tumor.* Sentinel node biopsy technique is used in the staging of certain types of cancer to see if they have spread to any lymph nodes. It is done using lymphosci...
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The patient should be nil per orally for 8 hours for solid food 6 hours for liquid and semisolid food 2 hours for clear liquid.
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Ans. (b) Sheep(Ref: Bailey 261e p37-38)Catgut points:* Discovered by John Hunter* Plain catgut is derived from Sheep submucosa of intestine* Plain catgut loses its strength by 50% in 3 days- Complete strength lost by 15 days and absorbed in 60 days* Isopropyl alcohol is used to preserve catgut.
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Ans. is 'a' i.e., Hyperhydrosis
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*Nerve involved in superior orbital fissure syndrome are 3rd, 4th, 6th and Ophthalmic division of 5th nerve.
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Colchicine is used during karyotyping to arrest the cell in metaphase In metaphase , all chromosomes lie at the equator
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post-marketing trial means phase IV trial Phase IV clinical trials are conducted to identify and evaluate the long-term effects of new drugs and treatments over a lengthy period for a greater number of patients Phase IV research takes place after the FDA approves the marketing of a new drug Pg.no.80 KD Tripathi Seventh...
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Glomus Tumour (Glomangioma)Glomus tumour is an uncommon true benign tumour arising from contractile glomus cells that are present in the aeriovenous shunts (Sucquet-Hoyer anastomosis). These tumours are found most often in the dermis of the fingers or toes under a nail; other sites are mucosa of the stomach and nasal c...
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Metamorphosia herein,patients perceive distoed images of the object . This results due to alteration in the ratinal contour caused by a raised patch of choroiditis. Ref :Ophthalmology A K Khurana 6th edition chapter-10 page no :162
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Ans. is 'b' i.e., 10
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Ans. is 'd' i.e., % body surface area x weight in Kgs x 4= Volume in ml This is the Parkland formula which is the simplest and most widely used formula. This calculates the fluid to be replaced in the first 24 hours. Half this calculated volume is given the first 8 hours, and the second half in the next 16 hours.
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Generation of Reducing Equivalents The major metabolic role of the pathway is to provide cytoplasmic NADPH for reductive biosynthesis of fatty acids, Co-enzymes of Fatty Acid Synthesis An impoant point to remember is that the co-enzyme utilised for de novo synthesis is NADPH. The sources of NADPH for fatty acidsynthesi...
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Ans. is 'd' i.e., Tachycardia * Amiodarone is a broad spectrum anti - arrhythmic drug which belongs to class III of the anti - arrhythmic drugs.* Following are the adverse effects -i) Fall in BP, bradycardia and myocardial depression occurs on i.v. injection.ii) Photosensitization and skin pigmentation occurs in about ...
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It cause the paralysis of facial muscle on the side of the face as the infection.
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Ans. is `d' i.e., None (All are Features of Acute severe Asthma) Symptoms of acute severe Asthma Breathlessness at rest Speak in words Unable to recline Respiratory rate > 30/min Loud insiratory and expiratory wheeze Hea rate > 120 Pulsus paradoxus > 25 Mental status agitated Functional assessment:? PEF < 50 or respons...
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The receptor for tge virus is the CD4 antigen and therefore the virus may infect any cell bearing the CD4 antigen on the surface.This is primarily the CD4 T lymphocytes. REF:ANANTHANARAYAN AND PANIKER'S TEXTBOOK OF MICROBIOLOGY 9TH EDITION PAGE NO-574
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PET scan are not routinely used in the evaluation of thyroid nodules, however, they may show clinically occult thyroid lesions. USG is the most sensitive method for diagnosing intrathyroid lesions. CT and MRI are neither specific nor sensitive in diagnosing the intrathyroid lesions.
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Bilateral destruction of hippocampus leads to anterograde amnesia. The patients will be capable of new learning and retain old pre-lesion memories, but they cannot form new long-term memories. Conversion of sho-term memory into long-term memory will not take place.
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Steatorrhoea is an increase in stool fat excretion of >6% of dietary fat intake seen in malabsorption syndromes.Steatorrhoea may lead to weight loss, it is often associated with fat-soluble vitamin deficiency.Elevated alkaline phosphatase and reduced calcium levels suggest vitamin D deficiency and elevated prothrombin ...
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Fixed Drug Combination (FDC) Two different drug moieties are combined into a single pharmaceutical formulation. * As a rule, two drugs are ideal for combination into a FDC only when they have comparable pharmacokinetics. E.g: Cotrimoxazole = Sulfamethoxazole (t1/2 -11h) + Trimethoprim(t1/2 - 10h) Syndopa = Levodopa (t1...
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Currently, graft aeriosclerosis (AKA graft vascular disease) is the most impoant limit to the long-term success of hea transplantation. For unknown reasons, the coronary aeries of transplanted heas undergo intimal thickening associated with hyperplasia of myocytes and fibroblasts and deposition of matrix. This results ...
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Scaphoid Fractures * The scaphoid is the most frequently fractured carpal bone, accounting for 71% of all carpal bone fractures. * Scaphoid fractures often occur in young and middle-aged adults, typically those aged 15-60 years. * About 5-12% of scaphoid fractures are associated with other fractures * 70-80% occur at t...
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.
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Ref Robbins 9/e p 73 Myeloperoxidase (MPO) is a peroxidase enzyme that in humans is encoded by the MPO gene on chromosome 17. MPO is most abundantly expressed in neutrophil granulocytes (a subtype of white blood cells), and produces hypohalous acids to carry out their antimicrobial activity. It is a lysosomal protein s...
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In HOCM there is ground glass interventricular septum.Egg on side appearance is seen in TGA. In TOF boot shaped hea is seen
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Corneal epithelium develops from Surface ectoderm. Corneal stroma develops from Mesoderm.
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Ans. is 'd' i.e., Brain
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The head of a newborn is about 55%–60% of adult head breadth, 40%–50% of adult height and 30%–35% of adult depth. The cranium to-face ratio in a newborn is 8:1.  With continued development, especially of the lower face, the ratio changes to 1:2 in adulthood. By the age of 8 years, the brain is nearly 95% of its adult s...
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Ans. is 'a' i.e., Malaria JSB (Jaswant-Singh-Bhattacherji) stain is a fairly rapid staining method for the detection of malarial parasites. This stain is superior to the field's stain because the parasites stain clearer and both thick and thin smears can be stained. However, preparations fade quite rapidly and this sta...
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Answer is D (Hepatitis) : Chronic Active Hepatitis is a cause fior distal type 1 Renal tubular acidosis which is associated with increased urinary loss of potassium. "A high urinary K+ excretion with systemic acidosis is a charachteristic feature of renal tubular acidosis. Chronic Active Hepatitis is an established cau...
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The history points to a recent viral infection that could contribute to the development of pericarditis. Acute Pericarditis -Most common cause of pericarditis is idiopathic or viral. -ECG findings: Hea rate= 75 bpm Axis= normal PR interval= 0.16 sec QRS= 0.08 sec QT= 400 msec Uniform ST segment elevation - Concave upwa...
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The oxygen dissociation curve can be shifted right or left by a variety of factors. A right shift indicates decreased oxygen affinity of haemoglobin allowing more oxygen to be available to the tissues. A left shift indicates increased oxygen affinity of haemoglobin allowing less oxygen to be available to the tissues Re...
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Ans. is c, i.e. Perform hysterectomyFriends, management of PPH has to individualised in each case. In this question, oxytocin and balloon tamponade have failed incontrolling PPH. Inspite of giving 4 units of blood, her vitals are unstable.She is a grand multipara [?] instead of trying any conservative surgery like B ly...
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Diabetic mother and macrosomia: - Macrosomia defined as excessively large baby (>4kg) Causes are: - * Obesity * Poorly controlled maternal diabetes and gestational diabetes * Postmaturity * Multiparity * Male fetus. In diabetes: Excessive glycemia produce macrosomia due to insulin and insulin like growth factors. Indic...
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Hydrops fetalis - Excessive destruction of the fetal red cells leads to severe anemia, tissue anoxemia and metabolic acidosis It is accumulation of fluid in the body of the fetus in two out of three compaments: ascites, pleural effusion, pericardial effusion Most common cause of immune hydrops fetalis - Rh incompatibil...
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Caloric sweeteners • Xylitol • Lactitol • Sorbitol • Lycasin Non calorie sweeteners • Saccharin • Asparatame (Nutra sweetner)
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Ans: C
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Dysmophic features with low calcium and murmur point towards DiGeorge syndrome. Features can be summarized using the mnemonic CATCH-22 to describe DiGeorge syndrome, with the 22 to remind one the chromosomal abnormality is found on the 22 chromosome, as below Cardiac Abnormality (especially tetralogy of fallot) Abnorma...
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Gracilis
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Ans. is 'b' i.e., Veebral aery Location of Berry aneurysms Berry aneurysms commonly arise at the bifurcation of major aeries. Approximately 85% of intracranial aneurysms arise on the anterior circulation, mostly on the circle of Willis. Three most common locations are: (Ref.- Harrison 17/e) - the terminal internal caro...
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Diagnosis can be made as Pneumonia. Pneumonia without any danger sign can be treated at home with Oral antibiotic. In case of presence of any danger signs, the patient has to admitted to the hospital or to be referred to higher center.
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Ans. Ascariasis
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Ans. (c) Incubation periodRef: Park textbook 22nd ed 196
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"Gastrinomas are either associated with MEN I syndrome (30%) or sporadic (70%). Duodenal gastrinomas is the most frequent site for both the forms” Most gastrinomas (50-70%) are present in the duodenum, followed by the pancreas (20-40%) and other intraabdominal sites (mesentery, lymph nodes, biliary tract, liver, stomac...
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Methylergonovine, prostaglandin F2a, prostaglandin E1 (Misoprostol), and prostaglandin E2 are all uterotonic agents than can be used in situations where there is a postpaum hemorrhage due to uterine atony. Terbutaline is a tocolytic that is used to promote uterine relaxation for preterm labour, a disastrous option in t...
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SSRI * IMPOANCE Most widely prescribed antidepressant * MECHANISM Specifically acts on serotonin transpoers and increases serotonin in synapse. DRUGS FLUOXETINE FLUVOXAMINE DAPOXETINE CITALOPRAM ESCITALOPRAM ESCITALOPRAM SERALINE PAROXETINE USE FLUOXETINE=============CHILDHOOD DEPRESSION FLUVOXAMINE===========OCD DAPOX...
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Answer is C (Down's Syndrome) : Ultrasonography in a case of Down's syndrome Q may reveal increased nuchal fold thicknessY (Note that this is also a .feature of Turner's Syndrome.Q
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Hemangiomas: These are the most common type of benign liver tumor. They sta in blood vessels. Most of these tumors do not cause symptoms and do not need treatment. Hepatocellular carcinoma is the most common primary malignant tumor of the liver and has a relatively low 5-year survival rate. Fibrolamellar carcinoma (FLC...
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Carotid atherosclerosis is a pathological thickening of the common or internal carotid intima, typically into focal areas known as plaques (or atheromata). Although atheromata can remain stable for many years, surface rupture of unstable (vulnerable) plaques leads to local thrombus formation, with subsequent embolisati...
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People who have Sturge-Weber syndrome usually have both facial and intraoral macular hemangioma, although the intraoral hemangiomas may also be of the exophytic variety. An additional characteristic is the "tramline" calcifications seen in lateral skull radiographs. Wood and Goaz - Differential Diagnosis of oral & maxi...
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Ans. is 'c' i.e. HBV predisposes Most common cancers in the world are --> Lung > Breast > Colorectal. As already stated before, HCC presents quite late and thus only 15-20% cancers are resectable. Most patients with unresectable lesions die within a year after diagnosis.
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Ans. is 'a' i.e., Flexion at MCP joint MuscleNerve supplyActionLumbricals (4)First and second: Median nerve; Third and fourth: Deep branch of ulnar nerve.Flex the MP joints & extend the IP joints of the fingers.Palmar interossei (4)Deep branch of ulnar nerve.Adducts digits, flex the MP joints and extends the IP joints....
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(A) HBsAg[?]HEPATITIS B VIRUS:oThe envelope contains a protein called the surface antigen (HBsAg), which is important for laboratory diagnosis & immunization.oHBsAg was known as Australia antigen because it was first found in the serum of an Australian aborigine.oGenome contains 4 genes that encode 5 proteins:-S gene e...
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Particularly affects the basal ganglia, particularly the putamen.
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The capsule of Cryptococcus can be demonstrated by Indian ink or nigrosin stain. capsules are prominent in Indian ink preparation. There are 4 serological types of capsular polysaccharide, it can be demonstrated by precipitation test. All others do not have capsules. Ref: Textbook of Microbiology, Ananthanarayan and Pa...
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Ans. is 'a' i.e., Type A personality Types of personalitiesA. Type A personality: - Type 'A' individuals are impatient, time-conscious, highly competitive, ambitious, hostile, and aggressive. They have difficulty in relaxing and are concerned about their status. Type A individuals are often highly achieving workaholics...
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Gamna gandy bodies in CVC spleen is characterised by calcific deposits admixed with hemosiderin on fibrous tissue. Gandy-Gamna nodules or Gandy-Gamna bodies, sometimes known as Gamna-Gandy bodies or Gamna-Gandy nodules, are small yellow-brown, brown, or rust-colored foci found in the spleen in patients with splenomegal...
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Spironolactone is a competitive antagonist of the aldosterone receptor. Hypokalemia and hypeension in patients with primary aldosteronism can be controlled by spironolactone, 50-100 mg/d. Although spironolactone is an effective aldosterone receptor antagonist, it is not without side effects that can limit its use in th...
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Conjugate vaccine is now available where polysaccharide antigen is conjugated to diphtheria toxoid which makes the vaccine immunogenic to children below 2 years. Monovalent and polyvalent vaccines containing capsular polysaccharide of Meningococci group A, C, W-135 and Y are available. Induces good immunity after a sin...
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(b) Mean = Median, not equal to ModeIn the given question,* Red curve is Bilaterally symmetrical, bell shaped curve, hence it's a Normal distribution- In Normal distribution, Mean = Median = Mode (Green vertical line)* Blue curve has two modes (both symmetrical too), hence it's a Bimodal distribution- Since Bimodal cur...
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Amiloride is a ENaC blocker which inhibits uptake of Lithium through ENaC channels and prevents its toxicity.
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Ans. is 'a' i.e., Herpangina . Amongst the given options only Herpangina is caused by enterovirus (Coxsackie group A) and the diagnosis is made by virus isolation from the lesions or from feces. . All other are respiratory viruses and are shed in respiratory secretions. Common Sites of Isolation of Picornaviruses Enter...
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After adenoidectomy , there might occur injury to Glossopharyngeal ( 9th ) nerve. The Glossopharyngeal nerve supplies sensory innervation to the mucosa of the nasopharynx. The Vagus nerve supplies sensory innervation to the lower pharynx and larynx.
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