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Middle age female
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Body of the lesion Between unaffected surface and dark zone Area of greatest demineralization Pore volume – 5% in periphery and 25% in center Quinoline inhibition – body appears transparent Water inhibition – Positive birefringence compared to sound enamel Striae of Retzius - prominent
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Ans. is 'c' i.e., Gamma-amino butyric acid * Gamma-aminobutyric acid (GABA) is the major inhibitory transmitter of CNS. It produces presynaptic (indirect inhibition).* Glycine is also an inhibitory transmitter and is mainly present in spinal cord. It produces direct inhibition.
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Ans. D. All of the aboveThyroid peroxidase enzyme is responsible for oxidation, organification and coupling of thyroid hormone. Thus, propylthiouracil is the inhibitor of thyroid peroxidase enzyme and modulate all the functions.
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Ans. B. G proteina. Taste pathways: -b. Receptor stimulation: -i. For sour Via mammaliondegenerin-I and by activating H+ -gated cation channelsii. For salt Via Epithelium sodium channels (ENaC) by direct application amiloride (diuretic) on tongue, inhibits the ENaC and abolishes the ability to taste salt.iii. For Sweet...
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Paracentesisis a form of body fluid sampling procedure, generally referring to peritoneocentesis (also called laparocentesis or abdominal paracentesis) in which the peritoneal cavity is punctured by a needle to sample peritoneal fluid The procedure is used to remove fluid from the peritoneal cavity, paicularly if this ...
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Ans. is 'd' i.e., Veins
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Ans. is 'a' i.e., Paired t-test In this question :- i) Data is quantitative (BP) ii) Paired sample from same patients, before and after treatment. o So, Paired t-test is the best.
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Ans. is 'a' i.e., Esmolol Nodalol is longest acting b-blocker. Esmolol is shoest acting b-blocker. Acebutolol possesses all activities i.e., cardioselectivity, paial agonist activity, membrane stablizing activity and lipid insolubility.
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L5 - SI disc space is the most commonly involved space in disc prolapse. "Lumbar intervertebral disc herniation is most common at L5 - SI and slightly less common at L4 - L5, and rare at L3 - L4 or above". "The disc at L5 - Si is most commonly involved, followed in order by L4 - L5 and L3 - L4". — Pocket book of ortho...
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Ans. is 'a' i.e., Simple diffusion"Steroid hormones generally pass easily across a plasma membrane by simple diffusion as they are lipid soluble" .........Principle of medical physiology"Steroid hormones are rapidly transported across the cell membrane by simple diffusion" ........ Physiology Review
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(Ref: KDT 6/e p57) Drugs used for the treatment of central (pituitary) diabetes insipidus are: - Desmopressin (selective V2 agonist) - Thiazides - Chlorpropamide - Carbamazepine Drugs used for the treatment of nephrogenic (renal) diabetes insipidus are: - Thiazides - Amiloride (for lithium induced) Thiazides are useful...
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Pseudoaneurysm is a rare condition arising from disruption in the arterial wall with blood dissecting into the tissues around the damaged artery creating a perfused sac that communicates with the arterial lumen. Its incidence is on rising due to the increase in endovascular procedures, hemodialysis and intravenous drug...
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Ans. A i.e. 6th
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Answer is A (Hemochromatosis): The association of Ahritis, hyperpigmentation of skin and hypogonadism suggests the diagnosis of hematochromatosis. Hematochromatosis (Disorder of iron storage) Inappropriate increase in intestinal absorption results in deposition of excessive amounts of iron in parenchymal cells with eve...
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Drugs approved by the FDA for migraine prophylaxis are propranolol, timolol, sodium valproate and methysergide. Other used drugs are amitriptyline, noriptyline, verapamil, phenelzine, gabapentine and cyproheptadine. Ref: Harrisons 16th Edition, Page 93 (table 14-11)
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Bullous Skin Lesions - Primary blistering autoimmune diseases (pemphigus, bullous pemphigoid, herpes gestationalis, cicatricial pemphigoid, dermatitis herpitiformis, linear Ig A disease, epidermolysis bullosa aquisita). Secondary blistering diseases (contact dermatitis, erythema multiforme, TEN). Infections (VZV, HSV, ...
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Ans. C: Anti-endomysial antibody
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RANSON'S Prognostic Criteria (for Non-Gall Stone Induced Pancreatitis) At the Time of Admission After 48 Hours Age > 55 years Fall in Hematocrit > 10 points WBC count > 16,000/mm3 BUN Elevation > 5mg/dL RBS > 200 mg/dl S. Ca2+ < 8 mg/dL LDH > 350 IU/L Base deficit > 4 mEq/L AST > 250 U/L Aerial PO2< 60 mm Hg Fluid Sequ...
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Cardiolipin Is a Major Lipid of Mitochondrial Membranes Phosphatidic acid is a precursor of phosphatidylglycerol, which in turn gives rise to cardiolipin. This phospholipid is found only in mitochondria and is essential for the mitochondrial function. Decreased  cardiolipin levels or alterations in its structure or met...
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Clinical types of after cataract(secondary cataract). After cataract may present as thickened posterior capsule, or dense membranous after cataract or Soemmering's ring which refers to a thick ring of after cataract formed behind the iris, enclosed between the two layers of capsule or Elschnig's pearls in which the vac...
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Ans. is c, i.e. Ring pessaryRef: Dutta Obs 6th/ed, p312-3; Shaw 15th/ed, p337-8; Williams Gynae lst/ed, p545-7 (for details of pessaries)3deg prolapse with pregnancyIn early months of pregnancyIn late months of pregnancyUp till 18 weeks as after that spontaneous correction occur because uterus becomes a pelvic organAdm...
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c) surface ectoderm refkhurana 3rd/e p. 8
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Answer is C (Increased LDL and Decreased total cholesterol) The major effect of Omega -3-polyunsaturated Fatty Acids on plasma lipids is to decrease serum triglyceride levels. They do not have a consistent effect on total cholesterol and LDL cholesterol however most studies have repoed a rise in LDL cholesterol and a d...
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The minimum duration required for diagnosis of Hypomania is 4 days. Hypomania is milder form of manic symptoms and not requiring admission or intensive care. Presence of hypomanic episodes with depressive episodes is characteristic of Bipolar Type II disorder. Other impoant minimum durations related to mood disorders: ...
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The patient is showing features of otosclerosis. It is a condition due to new spongy bone formation. About 50% of the cases may have a positive family history and deafness stas between the age of 20-30 years. Non surgical treatment of otosclerosis includes use of hearing aid and sodium fluoride. Use of high doses of so...
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Ans. is 'a' i.e., Magnesium ammonium phosphate Staghorn calculi:* Staghorn calculi are composed of struvite (MAP, magnesium ammonium phosphate) and are usually seen in the setting of recurrent urinary tract infection with urease producing bacteria (e.g. Proteus, Klebsiella, Pseudomonas and Enterobacter).* Calcium phosp...
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Cadherins are Ca2+-dependent transmembrane glycoproteins that mediated cell-cell adhesion. E-cadherin is expressed on the surface of all epithelium and mediates cell adhesion by "zipper-like" interactions. -Desmin (choice A) is an intermediate filament protein found in cells of mesenchymal origin. -Lysyl hydroxylase (c...
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D. i.e. Inferior Phrenic aery
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Ans: c (Astigmatism) Ref: AK Khurana, 4th ed, p. 81Corneal astigmatism may occur in pterygium due to fibrosis in regressive stage.Pterygium:* Wing shaped fold of conjunctiva encroaching cornea from either side within the palpebral fissure* Degeneration & hyperplastic condition of conjunctiva* May be unilateral or bilat...
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Ans. (b) Differential media Ref: Microbiology by Ananthanarayan and Paniker 8th ed. / 40 DIFFERENTIAL MEDIA (OR INDICATOR MEDIA) * It distinguishes one microorganism type from another growing on the same media. * This type of media is used for the detection of microorganisms and by molecular biologists to detect recomb...
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The definite (true) tuberculides are erythema induratuni (Bazin's disease), papulonecrotic tuberculid, Lichen scrofulosorum.
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Amiloride (10-40 mg/day) can be substituted for spironolactone in patients with tender gynecomastia. Amiloride is more expensive and less effective Ref: HEPATOLOGY, June 2009
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Answer is B (Troponin T/I) Cardiac specific Troponins (Troponin T and Troponin I) are the biochemical markers of choice for detection of Acute MI in both healthy individuals as well as atheletes. 'The measurement of cTnT and cTnl (cardiac specific Troponin T & I) is of considerable diagnostic usefulness and they are no...
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MC neoplasm of spleen: Lymphoma (Non-Hodgkin's lymphoma) MC primary tumor of spleen: Hemangioma MC primary malignant tumor of spleen: Angiosarcoma (Hemangiosarcoma)
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Chorionic villous biopsy
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Patients with Meniere's disease often have transient hearing loss in the affected ear(s) during the veigo episodes. With repeated episodes, the veigo often improves, but the hearing loss can become permanent. Patients with Meniere's disease can usually be treated with medication to reduce their veigo (antihistamines su...
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Choking is done in shot gun at muzzle end to present dispersions of pellets.
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Clinical criteria for the diagnosis of autism are based on the DSM-IV TR and ICD10 specifications. A diagnosis of autism is based on symptoms in three areas: difficulties in reciprocal social interaction, difficulties in communication, and the presence of restricted and repetitive behaviors or interests. Children with ...
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Ans. (A) Echinococcus multilocularis(Ref: Paniker's Text book of Medical Parasitology 8th ED; page No-131, 136)Echinococcus multilocularis causes multiple alveolar like lesions in the liver.Unilocular hydatid cyst disease: Echinococcus granulosusAlveolar hydatid cyst disease: Echinococcus multilocularis. It presents wi...
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Oat Small-cell carcinoma (oat cell) and adenocarcinoma of the lung, although the most common lung tumors associated with skeletal metastases, rarely cause Many solid tumors associated with hypercalcemia, paicularly squamous cell and renal tumors, produce and secrete PTHrP that causes increased bone resorption and media...
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Ans. is 'd' i.e., Oral acetazolamide Treatment of POAG (Primary open angle glaucoma) Following treatment options are available for POAG : Medical therapy :- Total medical therapy is the treatment of choice for POAG. Topical 13-blockers (Timolol, Betoxalol, Levobunolol, caeolol) are the drugs of choice. Topical prostagl...
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Ref Harrison 19 th ed pg 1540 MS and sinus rhythm, the P wave usually suggests LA enlargement ). It may become tall and peaked in lead II and upright in lead V1 when severe pulmonary hypeension or TS complicates MS and right atrial (RA) enlargement occurs. The QRS complex is usually normal
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Ans. (b) It is autosomal recessive disorder(Ref: Robbins 9th ed p 315)Several rare autosomal recessive cancer syndromes have been described that are characterized by hypersensitivity to certain kinds of DNA-damaging agents, such as ionizing radiation (Bloom syndrome and ataxia-telangiectasia), or DNA cross-linking agen...
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Oocytes develop from the primordial germ cells, which themselves are derivatives of epiblast. Ref: Gray's 39e/p-1289
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- Peripheral smear showing 'bite cells' after treatment with anti-malarials - suggests G6PD deficiency. G6PD deficiency: X-linked recessive disorder. Most common red cell enzyme deficiency. Hemolysis is seen d/t raised oxidative stress. FEATURES: Pallor, icterus, hemoglobinemia, hemoglobinuria, splenomegaly etc are see...
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Ans. is 'd' i.e., Resistance to INH and Rifampicin Treatment of multidrug resistance (MDR) TBo MDR-TB is defined as resistance to at least both INH and rifampicin. Previously it was classified as Category IV under DOTS (DOTS-PLUS).o The treatment is given in two phases, the intestive phase (IP) and the continuation pha...
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Bactericidal drugs kill the bacteria whereas bacteriostatic drugs only inhibits bacterial growth. Bacteriostatic activity is adequate for the treatment of most infections ,bactericidal activity nay be necessary for cure in patients with altered immune system like neutropenia ,HIV and other immunosuppressive conditions ...
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Whipple's disease is a rare, systemic infectious disease caused by the bacterium Tropheryma whipplei. Whipple's disease primarily causes malabsorption but may affect any pa of the body including the hea, brain, joints, skin, lungs and the eyes.Weight loss, diarrhea, joint pain, and ahritis are common presenting symptom...
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Ans. c. Common peroneal nerve (Ref: BDC 4th/Vol-II/174)'Common peroneal nerve (L4, L5, S1, S2) is the smaller terminal branch of sciatic nerve. The larger terminal branch of sciatic nerve is the tibial nerve. The common peroneal nerve is relatively unprotected as it traverses the lateral aspect of the head of fibula an...
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Ans. is 'd' i.e., Avidity testing must be done to differentiate b/w IgA & IgM Avidity test is used to measure the strength of antigen-antibody reaction for IgG antibody (not to differentiate betweenIgA & IgM) Toxoplasma immunoglobulins to diagnose congenital toxoplasmosis 1) IgG o Presence of IgG in infants's blood doe...
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The traditional laboratory diagnosis is based on light microscopy, which shows diastaseresistant, periodic acid-Schiff (PAS)-positive, non-acid-fast granules in ..... The distinction could be made by acid-fast staining, which is positive for patients infected with M. avium and negative for those with Whipple&;s disease...
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Cushing's ulcers are Stress ulcers that are associated with intracranial injury or an increase in intracranial pressure. About the site of involvement in Cushing's ulcer the maximum information I could get was from Robin's. It states "Gastric, duodenal and esophageal ulcers arising in patients with intracranial injury,...
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The medial umbilical fold overlies the obliterated umbilical aery . The peitoneum of the lower anterior abdominal wall is raised into five folds that diverge as they descend from the umbilicus. These include One median umbilical fold overlies the median umbilical ligament and extends from the umbilicus to the apex of t...
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The hepatotoxic octapeptides of Amanita phalloides usually produce massive hepatic necrosis; the lethal dose of the toxin is 10 mg, the amount found in a single death cap mushroom. Ref: Harrison's Principles of Internal Medicine, 18th Edition, Page 2558.
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The saphenous nerve travels with the great saphenous vein, running along the medial side of the leg and thigh. It provides cutaneous innervation to the medial leg and foot and does not provide motor innervation to any muscles. So, both the case history and the symptoms point to a saphenous nerve injury. Branches of the...
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Answer- B. LungAccumulation of fluid in the interlobar spaces of the lung (as a result of CHF) appears as a neoplasm on a radiograph.It is called as Phantom tumor or pseudotumor or vanishing tumor.
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Inherited deficiency of GpIIb-IIIa results in a bleeding disorder called Glanzmann thrombasthenia.(ref Robbins 9th/118)
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Ans. is 'd' i.e, Glucose Important educational points* 60-70% of glomerular filtrate is reabsorbed in proximal tubule.* Na+ reabsorption occurs in all segments of nephron excepting descending limb of loop of Henle. 60% (60-70%) of filtered Na+ is reabsorbed in proximal tubule. About 30% of filtered Na+ is reabsorbed in...
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Ans. is 'b' i.e., M. kansasii can cause disease indistinguishable from tuberculosis.Other choices:(a) M. tuberculosis and M. bovis are equally pathogenic.(b) M. africanum infection is acquired from human and cattles.(d) M. marinum causes swimming pool granuloma.
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Ans. (a) i.e. Listeria monocytogenes Among options provided listeria is the only Gr positive bacilli. Listeria accounts for 10% of cases of community acquired bacterial meningitis. For details see previous answers.
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Progressive supranuclear palsy presents with symmetrical parkinsonism, cognitive impairement, early falls and bulbar involvement. The charecteristic eye movement disorder, with up and down gaze. There will be dysahria, but not tremors. Reference : Harrison20th edition pg 2456
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Clinical features of osteogenesis imperfecta:- *Blue sclera * Dentinogenesis imperfecta *Generalized osteoporosis *Osteoporosis given rise to bowing and multiple fractures. Fracture are usually due to tril trauma but surprisingly heal well. *Radiology shows Wormian bones in the skull. Radiographic features vary accordi...
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Ans: A (Post ethmoid artery) Ref: Diseases of the Ear Nose and Throat by PL Dhingra 5th edn .2010.page 190Explanation:Kiesselbach's plexus is situated in the Little's area which is the anterior inferior part of the septumAnterior ethmoidal, septal branch of superior labial, greater palatine and sphenopalatine arteries ...
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Histamine. When IgE-sensitized mast cells are stimulated by antigen, preformed mediators of inflammation are secreted into the extracellular tissues. Histamine binds to specific H1 receptors in the vascular wall, inducing endothelial cell contraction, gap formation, and edema. Massive release of histamine may cause cir...
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Maximum milk output is seen at the age of 5-6 months Park 23e pg: 530
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Carcinoid hea disease Results from neoplasms of enterochromaffin cells. Can survive up to 10 years after diagnosis, because the tumors, although malignant, are slow growing. Associated with production of serotonin | Serotonin - Cardiac failure, due to fibrous deposits in the endocardium a- fibrous degeneration of the v...
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D i.e. GTP not required
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Disinfection of milk by pasteurization, water by chlorine and handwashing may be cited as examples of precurrent infection. Ref: 25th edition, Park's Textbook of Preventive and Social Medicine, Page no. 140
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B. i.e. Scabies
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. Hypersensitivity reaction with modified macrophages, lymphocytes and giant cells
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Transposons are also known as jumping genes Jumping genes/Transposons DNA sequences that can move from one chromosome locus to another
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1 Fc fragment & 2 Fab fragments REF: Jawetz, Melnick, & Adelberg's Medical Microbiology, 24TH edition Chapter 44 If an antibody molecule is treated with a proteolytic enzyme (eg, Papain), peptide bonds in the hinge region are broken. This breakage produces two identical Fab fragments, which carry the antigen-binding si...
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Progressive, symmetric motor weakness, areflexia, and autonomic instability, with mild or absent sensory signs, are typical features of Guillain-Barre syndrome. Frequently there is a history of infection (often respiratory) in the several weeks preceding clinical onset of the syndrome. Suppoive evidence for the diagnos...
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Ref: Park&;s Textbook of Preventive and Social Medicine 25 th Ed Pgno : 417-418
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Studies have concluded that tubal sterilization protects against ovarian cancer. There is no change in the incidence of breast cancer. The incidence of functional ovarian cysts is increased almost two fold following tubal sterilization. No repos of decrease in salpingitis after tubal ligation.
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Persons who are previously exposed to tuberculous infection shows incidence of reactivation of primary tuberculosis and the pattern of lesions in such cases is similar to that of primary tuberculosis i.e. with involvement of hilar lymph nodes rather than cavitary and apical lesions in the lung. In addition, infection w...
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Ans. A: DPT Park's PSM,21st ed., p-101 states "Deep freezers are used for making ice packs and to store OPV and measles vaccines" Among the vaccines, polio is the most sensitive to heat, requiring storage at minus 20 degree C. Vaccines which must be stored in the freezer compament are OPV and measles vaccine. Vaccines ...
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Thyroglobulin is a glycoprotein specific to the follicular cell, facilitates the conversion of MIT and DIT into T3 and T4. Measurement of peripheral thyroglobulin has predictive value for the recurrence of DTC (differentiated thyroid cancers) locally or in metastatic deposits after initial total thyroidectomy Source : ...
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Ans. B. Biceps
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Ans. is 'c' i.e., 100% immunization National population policy (2000)o Objectives of National Population Policy 2000# Immediate objectives: To meet unmet need of contraception; to strengthen health infrastructure; to strengthen health personnel and to promote integrated service delivery for basic RCH care# Mid term obj...
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Ans. Killing people randomly
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Algogens are pain producing substances and Bradykinin is the most potent algogen Ref:Guyton and Hall textbook of medical physiology 12th edition,page number:698,699,700
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Any trauma to the ciliary body can cause sympathetic ophthalmitis ; hence it is considered the dengerous area of the eye
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HYPERVITAMINOSIS A: Chronic hypervitaminosis A results from excessive ingestion of preformed vitamin A (retinol or retinyl ester), generally for several weeks or months. Toxicity can be induced in adults and children with chronic daily intakes of 15,000 mg and 6,000 mg, respectively. Signs of subacute or chronic toxici...
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(C) Myasthenia gravis # ENDOCRINE MYOPATHY:> Major categories of endocrine myopathy include those associated with Adrenal dysfunction (as in Gushing disease or steroid myopathy); Thyroid dysfunction (as in myxedema coma or thyrotoxic myopathy); Parathyroid dysfunction (as in multiple endocrine neoplasia); Pituitary dys...
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Phrenicocolic ligament is not attached to the spleen but supports its anterior end.
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For Karyotyping, the cell needs to be arrested in the Metaphase stage for separating the chromosomes. The monocytes do not divide and therefore, they cannot be used for Karyotyping).
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Vimentin
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Sildenafil is the DOC for erectile dysfunction.
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PLASMA MEMBRANE 1. The plasma membrane separates the cell from the external environment. It has highly selective permeability propeies so that the entry and exit of compounds are regulated. The cellular metabolism is in turn influenced and probably regulated by the membrane. The membrane is metabolically very active. 2...
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Anterior cranial fossa fracture Middle cranial fossa fracture Posterior cranial fossa fracture MC type of skull base fracture Caused by fracture of cribriform plate Clinical features: Subconjunctival hematoma CSF rhinorrhea Epistaxis Anosmia Periorbital hematoma or "Raccoon eyes" Carotico cavernous fistula Frontal lobe...
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A i.e. Berlin's edema
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At bih: Fixation at light held 8-10 inches away, momentarily 6-8 weeks:Fixation of light and objects more steady 3 months:Follows moving object 5-6 months:Depth perception, colour vision and eye-body coordination
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(Bluish discolouration in the umbilicus) (1124-Baily & love 24th) (1140-Baily & Love 25th)Acute Pancratitis* Bluish discolouration of the flanks - Grey Turner Sign* Bluish discolouration of the umbilicus - Cullen's sign.
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Desmoid TumourTumour arising in the musculoaponeurotic structures of the abdominal wall, especially below the level of the umbilicus.It is a completely unencapsulated fibroma. Distribution: Extra-abdominal (60%), abdominal wall (25%), intra-abdominal (15%).Some cases recur repeatedly in spite of apparently adequate exc...
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Aggregatory substances: TXA2 ADP Inhibits aggregation: PGI2. Aspirin is Irreversible inhibitor of COX - thus preventing TXA2 formation & aggregation of PLATELETS.
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Most of the side effects of steroids are mainly hoarseness, oropharyngeal candidiasis, decreased growth in children with adrenal suppression. • The plausible explanation is that since these drugs are inhaled, they avoid the first pass metabolism that orally administered steroids undergo and hence have a preponderance t...
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Ans. (a) P.S.A (Prostate specific antigen)Ref.: Bailey & Love 26th ed. /1341Prostatic acid phosphataseIt is elevated in:* Prostate cancer* Metastatic prostate cancerProstate specific antigenAs the PSA level increases, so does the risk of this disease. When the PSA is 1 ng/mL, cancer can be detected in about 8% of men i...
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The palatopharyngeus forms the posterior tonsillar pillar. It also functions to close off the nasopharynx and larynx during swallowing. The anterior tonsillar pillar is formed by the palatoglossus.
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