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Aconite is monk's hood or blue rocket or mitha zaher or bish or bikh. Signs and symptoms include sweet taste, numbness and tingling of mouth, tongue and pharynx, salivation, nausea, and vomiting and diarrhea. Headache, giddiness, pallor, and profuse sweating, subnormal temperature, and patient becomes weak.
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Ans. is 'b' i.e., Trigeminal ganglion o Trigeminal ganglion (Gasserion ganglion or semilunar ganglion) lies in a dural pouch, the cavum trigeminale (Meckel's cave).
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In bimodal series Mode = 3xmedian - 2xmean= 3x3 - 2x2 = 5 Ref : Park&;s Textbook of Preventive and Social Medicine; 23rd edition - Pgno. 847
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Ca"
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EIEC produce disease similar to shigellosis, i.e. invasion of mucosa. OPTION 1 Persistent diarrhea especially in developing countries is most often caused by EAEC. OPTION 2 Enterohemorrhagic E. coli (EHEC): Serotypes associated with EHEC are: - O157: H7 (most common serotype). - Manifestations: HC (hemorrhagic colitis)...
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Ans: c (SAAG >1.1 gm/dl) Ref: Harrison, 16th ed, p. 245,17th ed, p.In exudative ascites SAAG <1.1SAAG is serum ascites albumin gradient. It is the difference between serum albumin and ascitic fluid albumin. In exudative ascites, the ascitic fluid albumin is more so S AAG is less than 1.1 gm/dlExudative ascitesProtein c...
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Ans. is 'a' i.e., Bile duct paucity
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Ans. C. Cerebellar degenerative diseaseParaneoplastic cerebellar degenerationa. Pure paraneoplastic cerebellar degeneration:i. Breast & Gynecological cancer (Anti Yo antibodies)ii. Hodgkin's lymphoma (Anti Tr antibodies)b. Subacute cerebellar degenerationi. Small cell carcinoma lungii. Thymomaiii. Neuroblastoma
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50% of the focal nodular hyperplasia shows presence of Kupfer cells (phagocytes). So uptake of sulphur colloid is noted in these lesions. No uptake is seen in HCC, hepatic adenoma and metastases
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Ans. At the lamina cribrosa
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Pierre Robbin’s Sequence includes unilateral cleft lip.
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DNA and RNA Acridine orange is a nucleic acid selective metachromatic stain useful for cell cycle determination Acridine orange interacts with DNA and RNA by intercalation or electrostatic attraction respectively - DNA intercalated Acridine orange fluoresces green - RNA electrostatically bound acridine orange fluoresce...
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Epidemic: Number of cases of a disease clearly in excess of normal frequency. An area is declared free of epidemic; if on search , no new cases are repoed for 'twice the incubation period of the disease since the occurrence of last case'.
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SRS is a dual record system initiated to provide reliable estimates of bih and death rates.It consists of a continuous enumeration of bihs and deaths by an enumerator and an independent survey every 6 months by an investigator-supervisor.Park 23e pg: 841
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Kuntsher&;s clover leaf intra medullary nail (K nail). Fixation of the K nail is based on 3 point fixation. It fixes bone at 3 points, at either ends and at isthmus. REF:Essential ohopaedics- 5th edn- pg no 373.
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Ans. is `d' i.e., All of the above Impoant risk factors and their outcomes/diseases which have been studied by case-control study are :- Cigarette smoking and lung cancer. Maternal smoking and congenital malformation. Radiation and leukemia. OCP used and hepatocellular carcinoma. Herpes-simplex and Bells palsy. Aificia...
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Best prognosis : Duodenal adenocarcinoma >Ampullary carcinoma >Distal Bile duct adenocarcinoma >Head of pancreas >Body and tail of pancreas (DAD Head Body and Tail) Ref: Shackelford 7th edition Pgno : 1201
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Ans. C. Nucleotide Excision RepairDisorder shown: Xeroderma pigmentosuma. Xeroderma pigmentosum (XP) is a rare autosomal recessive genetic disorder of DNA repair in which the ability to repair damage caused by ultraviolet (UV) light is deficient.b. In extreme cases, all exposure to sunlight must be forbidden, no matter...
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Vital capacity is sum of ERV + TV + IRV. All these lung volumes are Reduced in Restrictive lung disease due to pulmonary fibrosis. Do not mix with Timed vital capacity which is a ratio of FEV1/ FVC and is increased in restrictive lung disease.
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Datura is atropine .antidote is physostigmine because it is a teiary amine which can cross BBB and neutralize central effects produced by atropine Ref: KDT 6th ed pg 101-102
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32 - 34 weeks : sta feed by spoon or paladai ( Total enteral nutrition ) Ref : Ghai pediatrics eighth edition pg no 159
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(Richter's hernia) (1274-Baily & Love 24th) (970-B &L 25th)1. Richter's hernia - is a hernia in which the sac contains only of portion of the circumference of the intestine (usually small intestine). It usually complicates femoral and obturator hernias2. Littre's hernia - A meckel's diverticulum3. Spigelian hernia - Th...
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Ascending loop of Henle has Na+ - 2Cl - K+ cotranspoer. Ref: Ganong's review of medical physiology; 24th edition; page no; 685 ref of image :
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Answer- B. TetrodotoxinThe toxin involved is tetrodotorin.Syrnptoms of pufferfish poisoning include initial tingling, numbness of lips, tongue and fingers. trading to the paralysis of the extremities, ataxia, difficulty in speaking, and finally death by asphpiation sue to respiratory paralysis.
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Stem cell therapy has the potential to provide treatment for a wide range of diseases, including spinal cord injury and neurodegenerative conditions, cardiovascular disease, degenerative retinal conditions, type I diabetes and diseases of the musculoskeletal system.Risks of cell-based therapy.Tumour formationGenetic an...
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Ans. is `d' i.e., Phallic
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2 molecules of CO2 which are lost in TCA, are from Oxaloacetate. Acetyl CoA in one turn of the cycle gives it's carbons to oxaloacetate, not CO2. In the 2nd turn of the cycle , these two carbons from Oxaloacetate will be lost in the form of CO2. Answer oxaloacetate >>Acetyl CoA.
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Human genome: Size: 3 billion base pairs Number of genes: <25,000 At least 30% of the genome consists of repetitive sequences Alu family constitutes ~10% of human genome Largest gene: DMD gene coding for dystrophin protein Only around 1.5 % of human genome is made of protein-coding (exonic) DNA
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In x-ray of mechanical obstruction, there will be absence of rectal gas shadow.
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Tegmen tympani forms the roof of the middle ear and it also extends posteriorly to form a roof of aditus and antrum.
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In the first trimester, placental growth is more rapid than that of the fetus. But by approximately 17 weeks, placental and fetal weights are approximately equal. Ref:Williams Obs 24e pg 95.
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Mercury
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Beta-2 microglobulin and not beta macroglobulin may be used as a tumor marker (as in multiple myeloma).
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8th day
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The phenomenon of 'nuclear induction', later to be termed 'nuclear magnetic resonance' (NMR), was described by Bloch and Purcell and their colleagues in 1946. NMR has been used extensively for studying the propeies of matter at the molecular level (NMR spectroscopy). In applications to medicine, the term 'nuclear' has ...
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Respiratory rate is not a component of Apgar score; however, respiratory effo is: The Apgar score is an objective method of evaluating the newborn&;s condition using the 5 parameters stated below It is performed at 1 minute and 5 minutes after bih Components of APGAR score: Color (A Appearance) Hea rate (P Pulse) Respo...
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- Neonatal tetanus can be prevented by giving: Primigravida - 2 doses of td as soon as possible. Multigravida- If pregnancy occurs within 3 years of 1st pregnancy -1 dose of td booster is given. If pregnancy occurs after 3yrs of 1st pregnancy- 2doses should be repeated.
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. Prader -Willi syndrome
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Talon cusps appear to occur more frequently in Asians, Native Americans, the Inuit, and those of Arab descent. Both sexes may be affected, and the occurrence may be unilateral or bilateral.  In isolated cases, genetic influences appear to have an effect, because identical talon cusps occasionally have been documented i...
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Barrier method
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Ans. Squamous cell carcinoma
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85 dB
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Ans. is 'd' i.e.. All the above Treatment of ADHDPharmacotherapy Pharmacological treatment is considered to be the first line of treatment of ADHD. Drugs used for ADHD areCNS stimulants: - These are drugs of choice for ADHD. Methyiphenidate is the drug of choice. Other CNS stimulants used are dexmethyiphenyldate. dextr...
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Acidosis (↓ pH) precipitate sickling.
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A cancer that stas in the bone. In the ends of bone where new bone forms as the person grows. Thigh, upper arm, shin are the common sites.
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Ans. is `d i.e., AndrogensThe adrenal coex is divided into three zones (outer to inner) : Zona glomerulosa, zona fasciculata and zona reticularis.All three coical zones secrete coicosterone, but the active enzymatic mechanism for aldosterone biosynthesis is limited to the zona glomerulosa whereas the enzymatic machanis...
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G(s) alpha mutations in fibrous dysplasia and McCune-Albright syndrome. Weinstein LS1. Author information Abstract Fibrous dysplasia (FD) is a focal bone lesion composed of immature mesenchymal osteoblastic precursor cells. Some FD patients also have hyperpigmented skin lesions (cafe-au-lait spots), gonadotropin-indepe...
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A density of 15 microfilaria / drop of blood are needed to make it infective.
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C i.e. Multiple myeloma Features Disease Multiple punched out lesions Multiple myelomaQ Hair on end skull vault ThalessemiaQ, Sickel cell Anemia Erosion of dorsum sella Raised ICT (earliest & most common) Silver Beaten app. of vault Raised ICT Sunray calcification with spicules Meningioma
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Ans. is 'b' i.e., ARAutosomal recessive disordersMetabolicHematologicalEndocrineSkeletalNarvouso Cystic fibrosiso Phenylketonuriao Galactosemiao Homocystinuriao Lysosomal storage diso a1-antitrypsin deficiencyo Wilson diseaseo Hemochromatosiso Glycogen storage disorderso Sickle cell anemiao Thalassemiaso Congenital adr...
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Ans. D: Atracurium Suxamethonium should be avoided if hyperkalaemia is present. Some non-depolarising muscle relaxants depend on the kidney for elimination. Atracuriuin is the agent of choice as it undergoes spontaneous Hoffman degradation at body temperature. Vecuronium and mivacurium are safe to use in renal failure ...
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Marasmus is characterized by gross wasting of muscle and subcutaneous fat. The body weight is less than 60% of the expected weight for age. The affected child will be active and has a voracious appetite. Ref: Page 104; Ghai Essential Pediatrics; 6th edition
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Ans. (d) Absent P waves.In hypokalemia, the ECG shows1. Increased amplitude and width of the P wave2. Prolongation of the PR interval3. T wave flattening and inversion4. ST depression5. Prominent U waves (best seen in the precordial leads)6. Apparent long QT interval due to fusion of the T and U waves = long QU interva...
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Sclerosing adenosis is a type of proliferative fibrocystic disease that is often seen with other variants of fibrocystic disease. It is a proliferation of small ducts and myoepithelial cells near the terminal duct lobular unit. It also is characterized by fibrosis that distos the glands and lobules into a whorled patte...
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Spectrophotometry is not a rapid serological test it is a quantitative measurement of the reflection or transmission propeies of a material as a function of wavelength. A spectrophotometer is commonly used for the measurement of transmittance or reflectance of solutions, transparent or opaque solids, such as polished g...
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Ans. is 'd' i.e., Velocity of bullet > 'a' i.e., Weight of bullet o Tissue damage (or destructive power of bullet) is dependent on striking (kinetic) energy of bullet, which is proportional to its mass and square of velocity (KE = 1/2 mv2). So modem bullets are designed to have smaller mass allowing transportation of l...
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(Ref: Harrison 18/e p866, 17/e p645-646, Tejinder Singh 2/e p54-61)   Peripheral blood picture Bone marrow picture Macrocytosis (↑ MCV, MCH. Normal MCHC) Peripheral smear            Macroovalocytes            Few nucleated RBCs            Evidence of dyserythropoiesis like- Basophilic stippling Cabot ring ...
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Heroin is a semi synthetic derivative of opium. Withdrawal symptoms are lacrimation, sweating, yawning,anxiety,restlessness, rhinorrhoea and tremors seen 8-12 hours after last dose. All the other drugs donot have the above set of side effects. Ref: KD Tripathi 8th ed.
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Depersonalization / Derealisation is a type of dissociative disorder where patient feels detached from himself and world. He feels as if he is an external observer of his body.
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Ans. is c, i.e. Endometrial cultureRef: Williams Gynae 1st/ed, p420; Leon Speroff 7th/ed, p419Asherman's syndrome:* It is an acquired uterine defect characterized by the presence of uterine synechiaes and subsequent destruction of the lining endometrium.* M/C cause for asherman syndrome -Postpartum curettage* 2nd M/C c...
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Presence of uniocular diplopia together with the finding of the golden crescent on oblique illumination (edge of subluxated lens) or black crecent line on coaxial illumination (edge of subluxated lens) suggests a diagnosis of `subluxation' of the crystalline lens. Ectopic lens refers to the displacement of shows lens f...
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This female patient's symptoms are classic for a primary elevation of ACTH (Cushing's Disease). Exogenous steroids would produce similar symptoms, except that circulating ACTH would be low because of negative feedback suppression at both hypothalamic (CRF) and anterior pituitary levels (ACTH). Addison's Disease is caus...
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Achondroplasia Trident hand Champagne glass pelvic inlet Bullet vertebra.
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Screening of all blood donations should be mandatory for the following infections and using the following markers: HIV-1 and HIV-2: Screening for either a combination of HIV antigen-antibody or HIV antibodies. Hepatitis B: Screening for hepatitis B surface antigen (HBsAg). Hepatitis C: Screening for either a combinati...
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In immediate hypersensitivity (type I hypersensitivity), the injury is caused by TH2 cells, IgE antibodies, and mast cells and other leukocytes Mast cells release mediators that act on vessels and smooth muscle and proinflammatory cytokines that recruit inflammatory cells. In antibody-mediated disorders (type II hypers...
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C3 def can lead to recurrent pyogenic infections C1 inhibitor deficiency can lead to hereditary angioneurotic edema Ref: Textbook of Microbiology Baveja 5th ed Pg 125
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Subpoena/ summons is a document compelling the attendance of a witness in a cou of law, under penalty, on a paicular day, time and place for the purpose of giving evidence. Sec. 61-69 CrPC deals with the summons. A subpoena can be of two types: i. Subpoena duces tecum: Person is required to bring ceain documents or oth...
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Typical Neisseria are gram-negative diplococci. Neisseria gonorrhoeae contain pili, hair-like appendages that may be several micrometers long. They enhance attachment of the organism to mucous membranes, helping to make the organism more resistant to phagocytosis by WBCs. Gonococci isolated from clinical specimens prod...
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Hypokalemic periodic paralysis is a familial condition caused by missense mutations of voltage sensor domains within L-type calcium channels or the skeletal Na+ channel. Must know: Thyrotoxic Periodic Paralysis: Redistributive hypokalemia occurs in the setting of hypehyroidism. It can cause periodic attacks of hypokale...
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The common site of relapse of ALL → i) Bone marrow (most common - 20%), ii) CNS (5%)  iii) Testis (3%)
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In hydrocution (immersion syndrome / submersion inhibition) death occurs as a result of cardiac arrest which in turn is due to vagal inhibition of the hea. The cold water may stimulate nerve endings on the body surface, ear drum, nasal passage, larynx etc. leading to vagal stimulation resulting in cardiac death. Ref: E...
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Ref: KDT 6/e p444 'Weight gain ( not weight loss) in seen with TCAs.
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Percussion is one of the oldest pulp vitality tests used because it requires no armamentarium. Generally, patients who have a tooth sensitive to mastication have already percussed the tooth in question with their own finger tip(s) and informed the dentist which teeth are sensitive. Percussion is an indirect means of te...
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In aging or debilitating diseases the phospholipid end-products of membrane damage mediated by oxygen free radicals to get eliminated by intracellular lipid peroxidation. These, therefore, persist as collections of indigestible material in the lysosomes; thus lipofuscin is an example of residual bodies. Ref: Textbook o...
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The prevention of legionellosis involves minimizing production of aerosols in public places from water that may be contaminated with Legionella. Prevention is complicated by the fact that, compared with other environmental bacteria, Legionella bacteria are relatively resistant to chlorine and heat. The bacteria have be...
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Ans. is 'b' i.e., WPW syndrome o In WPW, the bundle of Kent is an accessory pathway which allows fast conduction to the ventricles and consequently leads to complaints of palpitations and reduction of PR interval.PR interval has an inverse relation with heart rateo All other options are characterized by bradycardia the...
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Loco Parentis: In an emergency involving children, when parents or guardians are not available, consent is taken from the person in charge of the child. Paternalism: Is an abuse of medical knowledge so as to disto the doctor-patient relationship in such a way that the patient is deprived of his autonomy, or his ability...
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ref : maheswari 9th ed
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Monochorionic pregnancies have dividing membrane that is 2 layer thick. Monozygous twins can be dichorionic as well.
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During post disaster phase, All vaccines are contraindicated especially typhoid, cholera and tetanus toxoid. (except measles) Whereas post disaster, typhoid, cholera and tetanus toxoid are mandatory in health workers.
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“The most common virus causing sporadic cases of encephalitis in immunocompetant adult are HSV-1, VZV, EBV and less commonly enterovirus.” Remember: Epidemic of encephalitis are caused by Arbovirus which include: Alphaviruses Toga viruses Bunyaviruses
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Ans) a (Hallucination) Ref Ahuja 6/E page 59Perception of objects without stimulus is hallucination.Delusion-Are false unshakable beliefs which are not in keeping with the patients sociocultural and educational background and not amenable to reasoningIt is a disorder of thoughtTypes of delusions in the following condit...
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Popliteus has an intracapsular origin from the lateral femoral epicondyle. It inses on the posterior surface of the tibia, just proximal to the soleal line. Popliteus tendon is intracapsular but Extra-aicular and Extra-synol. Tendon of Long head of Biceps brachii is intracapsular and intra-aicular but extra-synol.
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Ans. (b) Organophosphate poisoningRef Katzung Pharamacology 10th ed. Ch 7* In organophosphate poisoning, the organophosphate cholinesterase inhibitors are well absorbed from the skin, lung, gut, and conjunctiva--thereby making them dangerous to humans and highly effective as insecticides.* These organophosphates irreve...
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Monospot test is also known as Paul Bunnel test.
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b. Type 7(Ref: Nelson's 20/e p, Ghai 8/e p 200-201)Quadrivalent HPV vaccine contains serotypes 16, 18, 6 & 11 with aluminium containing adjuvant.
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The answer is D: Reactive oxygen species. Ischemia/reperfusion (I/R) injury is a common clinical problem that arises in the setting of occlusive cardiovascular disease, infection, transplantation, shock, and many other circumstances. The genesis of I/R injury relates to the interplay between transient ischemia and the ...
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Testicular descent through the inguinal canal is controlled in pa by Leydig cell production of insulin-like factor 3 (INSL3), which acts a receptor termed GREAT ( G protein-coupled receptor affecting testis descent). Ref Harrison 20th edi page no 2769
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Antipsychotic drugs Extrapyramidal symptoms- dur to D2 blockade in limbic system Extrapyramidal symptoms Clinical features Special DOC Acute dystonia Oculogyric crisis ocular muscles spasm and opisthotonos Toicollis Protrusion of tongue leading to laryngospasm Grimacing Earliest to develop (days) Anticholinergic drugs ...
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Ans. Doctor-cou
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Dinitrophenol is an uncoupling agent, that disconnects electron transport from phosphorylation and generates lot of heat at the cost of ATP. Other options are inhibitors of electron transport chain.
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(A) Naloxone # Typical syndrome, which includes shallow and slow respirations, pupillary miosis (with mydriasis once brain anoxia develops), bradycardia, hypothermia, and stupor or coma is seen in Opioid Toxicity and Overdosage.> If not treated rapidly, respiratory depression, cardiorespiratory arrest, and death can en...
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CRISPR is acronym for clustered regularly interspaced short palindromic repeats.
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The curve is shifted downward and to the right (compliance is decreased) by pulmonary edema and interstitial pulmonary fibrosis. Pulmonary fibrosis is a progressive restrictive airway disease in which there are stiffening and scarring of the lung. The curve is shifted upward and to the left (compliance is increased) in...
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The most common location of a Meckel's is the terminal ileum usually located 45-90 cm from the ileocecal valve.The location on the antimesenteric border is normal and is not an indication for surgical resection. Also Know:The most common complication from Meckel's diveiculum is bleeding secondary to ulceration of the h...
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Ans. is `B' i.e., Supraclavicular Brachial plexus block This is the second most commonly practised block after central neuraxial block (spinal & epidural anaesthesia). Brachial plexus block is used for upper limb surgeries. Brachial plexus can be blocked by 4 approaches : - 1. Interscalene approach Brachial plexus is b...
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Ans. is 'c' i.e., Hypoglycemia Problems of full term small for date infants (IUGR) o Bih asphyxia o Hypoglycemia o Hypocalcemia o Meconium aspiration syndrome o Infections o Hypothermia o Polycythemia & Hyperviscocity
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Ans. is 'b' i.e., Occurs immediately after death Cadaveric spasm (instantaneous rigor or cataleptic rigidity)o Instantaneous rigor is defined as the condition wherein a group of muscles, which were in contracted state at the time of death, continue to be in spasm after death, without the stage of primary relaxation. It...
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Erythema annulare centrifugum (EAC) Epidemiology :- * Peaks in fifth decade Pathogenesis:- * Unknown, but may be an immune reaction to an antigen such as infection (e.g., tinea pedis, other dermatophyte infections, other fungi, viruses, and parasites), drug, pregnancy, and neoplasms (usually lymphoproliferative maligna...
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-Vitamin C plays the role of a coenzyme in hydroxylation of proline and lysine while protocollagen is converted to collagen  (i.e.  post-translational modification). The hydroxylation reaction is catalysed by lysyl hydroxylase  (for  lysine)  and prolyl  hydroxylase (for  proline). -Hydroxylation of  glycine  is  carri...
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