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Ans. is 'c' i.e., Increased calcium release from saroplasmic reticulum Peusis toxin . Peussis toxin is an exotoxin that has A and B subunits. . B subunit binds to the target cells whereas A subunit acts on the target. . First, the peussis toxin itself gets activated by glutathione and ATP. . Once the toxin gets activat...
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Ans. is 'b' i.e, Angina o The drug that inhibit fatty acid oxidation is Trimetazine. o These drugs are paial inhibitors of FA oxidation o These drugs also inhibit lipid peroxidation ---> Reduce the generation of free radicals o These drugs are indicated for the treatment of chronic angina pectoris who failed to respond...
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Chronic osteomyelitis is the most common complication. Other complications are : septicemia and pyemia septic ahritis metastatic infection to other body pas pathological fractures altered growth from damage to epiphyseal growth plate recurrence. malignancy can be seen in chronic osteomyelitis. image of acute osteomylit...
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A
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Ans. D. 20ml/min.rate of elimination = amount of drug excreted per hour concentration in urine x urine flow 2mg/min = 100 mg% x 2 ml/minNow Cl = RoE/Plasma concentration Therefore, Clearance =2mg/min/10mg%=20ml/min.
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Von Gierke's disease is a glycogen storage disease caused by a deficiency of glucose-6-phosphatase. It typically presents with neonatal hypoglycemia, hyperlipidemia, lactic acidosis, and ketosis. Failure to thrive is common in early life; convulsions may occur due to profound hypoglycemia. The glycogen accumulation in ...
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Endemic typhus is is caused by Rickettsia typhi and is transmitted to humans by the rat flea Xenopsylla cheopis. When the flea bites humans it defecates and the organism enter through the bite wound into the blood. After an incubation period of 1-2 weeks patients gets headache, fever and myalgia. They develop a maculop...
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Ans. (b) EndocytosisEndocytosis is the process of taking contents inside the cell. It involves fusion of two cell membranesExocytosis is release of contents from inside of the cell to outside. It involves fusion of vesicles inside the cell to its cell membrane
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C i.e. Krait
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Ans. a. Submental disorderMajority of children with Down syndrome function in mild to moderate range of mental retardation.Down syndrome/Trisomy 21:Genetic disorder caused by presence of all or part of a third copy of chromosome 21.Typically associated with physical growth delays, characteristic facial features and mil...
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X0 is indicative of Turner’s Syndrome.
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BFHI was launched in 1992 by the UNICEF and was adopted in India in1993. Ref: Nutrition and Child Development, K.E. Elizabeth, 4th edition pg: 1
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Ans: C (Type IIIA) Ref: Rockwood and Green 's Fractures in Adults, 7th EditionExplanation:Compound fractures are classified under the Gustilo Anderson Classification of Open FracturesTYPE ILow-energy clean woundcl cm with minimal soft tissue injury and comminutionTYPE IIWound >1 cm with moderate soft-tissue damage and ...
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Perilymph fistula: In this condition, perilymph leaks into the middle ear through the oval or round window. It can follow as a complication of stapedectomy or ear surgery when stapes is accidentally dislocated. It can also result from sudden pressure changes in the middle ear (e.g. barotrauma, diving, forceful Valsalva...
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Epiploic foramen of Winslow is the passage of communication, or foramen, between the greater sac and the lesser sac (omental bursa).It has the following borders:1.Anterior: the free border of the lesser omentum, with the common bile duct, hepatic aery, and hepatic poal vein between its two layers. 2.Posterior: the peri...
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Once infected with HIV ,it is infected for life.strictly speaking,the term AIDS refers only to the last stage of the HIV infection.so the moality is 100%(Ref.PARK'S TEXTBOOK OF PREVENTIVE AND SOCIAL MEDICINE 21st Edition page no.316)
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Ans. D. Endometrial cancer and breast cancerNulliparity and late menopause are factors associated with increased exposure to estrogen, hence they are operative in endometrial hyperplasia, Unopposed estrogen stimulation is not operative in endometrial polyps, cervical cancer, or vulvar cancer
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Ans. C: Hyperophic cardiomyopathy Pulsus paradoxus (PP), also paradoxic pulse or paradoxical pulse, is an exaggeration of the normal variation during the inspiratory phase of respiration, in which the blood pressure declines as one inhales and increases as one exhales. It is a sign that is indicative of several conditi...
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A i.e. Nicotinic cholinergic receptorReceptors with intrinsic ion channelThese cell surface receptors enclose ion selective channels (Na+, Ca2+, CO within their molecule. Agonist binding opens the channels & causes depolarization / hyperpolarization depending on the ion that flows through.This includes: - Nicotinic cho...
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Most Commonly used Piezoelectric Crystal in Ultrasound probe is Lead Zirconate Titanate. Quaz is a natural piezoelectric crystal. Piezoelectric Crystals conve electrical energy into sound waves and sound waves back into electric current. Ultrasound transducers act as both transmitter and receiver. Other impoant points ...
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Ans. (c) SteroidsRef: Harrison's 18/e, chapter 295
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Dhat syndrome is seen in some Indian communities, where patient believes he is passing semen in urine and that leads to weakness.
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Ans. Irritation by hair of caterpillar
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Penetrating wounds produce hemorrhage and blast effects. The "blast effect" of a high-velocity projectile causes an immediate increase in supratentorial pressure and results in death because of impaction of the cerebellum and medulla into the foramen magnum. A low-velocity projectile increases the pressure at a more gr...
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c. 16 years(Ref: Nelson's 20/e p 2673, Ghai 8/e p 534)Delayed puberty is defined as absence of secondary sexual characters by 14 yrs age or absence of menarche by 16 years.
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The technique employed in radiotherapy to counteract the effect of tumour motion due to breathing is known as gating. In gated radiotherapy, beam is turned on only during a ceain phase of respiratory cycle, generally at the end of expiration. Respiration is monitored using external markers placed on the patients chest,...
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Ans. is 'd' i.e., Standardized moality rate Special incidence rates i) Attack rate (case rate) ii) Secondary attack rate iii) Hospital admission rate
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Ans. (d) Fall in blood pressure by adrenaline pretreated with phentolamine(Ref: Ganong, 25th ed/p.353)If the subject is given a blocker and then if epinephrine is injected, vasodilation and decrease in BP is seen. This effect is called "Vasomotor reversal of Dale"
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Thromboxane A2, prostacyclin, and prostaglandins are formed by the cyclooxygenase pathway whereas leukotrienes are formed by the lipooxygenase pathway.Ref: Textbook of medical physiology by N Geetha, 2nd edition, page no. 103
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Endonuclease Exonuclease Cut in between the DNA sequence Cut from the sides either from 5' or from 3' side Cut ds DNA Cut ss & ds DNA
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Most common cause of mental retardation is Down syndrome followed by Fragile X syndrome.
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Ans. a. Kennedy phenomenon (Ref : Reddy's 33/e p231, 31/e p 214)'Kennedy Phenomenon: Surgical alteration or suturing of gunshot wounds creates problems. The evaluation of the wound, whether it was an entrance or an exit wound becomes difficult.'Mac-Naughten's rule (The right or wrong test; The legal test):An accused pe...
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Pellagra is characterised by deficiency of tryptophan, leading to photosensitivity on exposure to uv light three D'sof pellagra diarrhoea dermatitis dementia some impoant cutaneous features gauntlet of pellagra-sun burn over Dorsum of hands castles necklace- dermatitis over neck extending to anterior chest. cheliosis s...
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Most common type of cutaneous tb is lupus vulgaris iadvl textbook of dermatology , page 245
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Cervical was are seen with HPV type 6,11 which are of low oncogenic potential and HPV type 16,18 which are of high oncogenic potential. From illustrated synopsis of dermatology and sexually transmitted diseases neena khanna 5th edition page no 287
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High affinity but low intrinsic activity. The activity is mainly governed by affinity , intrinsic activity of a drug. iagonist has high affinity and intrinsic activity,antagonist has affinity but no intrinsic activity zero. Paial agonist has high affinity and low intrinsic activity. KDT 6/e pg 37
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The course of muscle necrosis in dermatomyositis can be best followed by repeated CK determinations. Repeated muscle biopsies are rarely required. However, the goal of therapy is to increase muscle strength and function, so following muscle strength is the key clinical assessment of response to therapy.
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Bushke - Lowenstein tumour (verrucous carcinoma): Tumor destroy adjacent tissue by compression, No metastasis usually (Locally malignant) Verrucous carcinoma is a locally aggressive form of condyloma acuminata. Wide local excision is TOC Topical immunomodulators- Imiquimod (Aldara)can be given Very large lesions may re...
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Ref: Pal GK. Cardiac output. In: Textbook of Medical Physiology. Ahuja Publishing House. 2007Explanation:Parameters increased with AgeingBlood pressureFat proportionADHProstateParameters decreased with AgeingLung complianceGlucose toleranceGFRRenal clearanceAcid secretionColonic motilityNo change with AgeingHematocrit
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The most common site is posterior part of nasal cavity close to the margin of sphenopalatine foramen. The tumor starts adjacent to the sphenopalatine foramen. Large tumors are frequently bilobed or dumbbell-shaped, with one portion of tumor filling the nasopharynx and the other portion extending to the pterygopalatine ...
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Montelukast, zafirlukast and pranlukast are Cys-LT1 receptor antagonists. Zileuton inhibits the production of leukotrienes by inhibiting the enzyme 5-lipoxygenase.
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Causes of SIADH = 1. CNS infection 2. Trauma 3. Meningitis 4. Encephalitis 5. Ectopic Ca tumor Option B: Pit Adenoma = Prolactinoma (increase prolactin), | GH Option C: Lithium = Causes Nephrogenic diabetic insipidus -Manifestation of SIADH- Dilutional Hypernatremia Treatment of SIADH = Vaptan tolvaptan
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Ans. B) Obturator nerveObturator nerve is the chief nerve of the medial (adductor) compament of thigh.
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Answer is B (Basal ganglia): The basal ganglia is the most common site of hypeensive haemorrhage The most common site of hypeensive haemorrhage within basal ganglia is the Putamen. The most common sites of hypeensive haemorrhage are : The basal ganglia (putamen, thalamus and adjacent deep white matter)- commonest Deep ...
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Egg shell calcification of Hilar Lymph nodes is not seen in Aspergillosis.
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Ans. is "a* i.e., Achondroplasia o Trident hand is seen in achondroplasia.Important radiological featuresDiseaseo Trident Hando Champagne glass pelviso Scottish terrier dog orScottish dog wearing a col loro Be-headed scotty dog signo Inverted napoleon's Hat signo Gulfs wing appearanceo Opera glass deformityo Cup and pe...
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ANSWER: (A) ImatinibREF: Harrison s 17th ed, CMDT 2008 p. 444The drug treatment of choice for CML when Allogenic SCT (stem cell therapy) is not feasible is IMATINIBIFN-tz used to be the drug treatment of choice for CML when IMATINIB was not available
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Compression of communication between medial and lateral plantar nerves is a common cause for neuralgic pain in foot. At the flexor retinaculum, the tibial nerve divides into the lateral and medial plantar nerves, compression here results in tarsal tunnel syndrome. Tarsal tunnel is located deep to the flexor retinaculum...
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The mRNAs, rRNAs, and tRNAs are directly involved in protein synthesis while the other RNAs paicipate in either mRNA splicing (snRNAs) or modulation of gene expression by altering mRNA function (mi/siRNAs) and/or expression (lncRNAs).The miRNAs do not encode proteins; instead, they function primarily to modulate the tr...
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Ans. D: Median Nerve Supracondylar humerus fracture: Most common < 10 years, peak age 5-8 years Constitutes 80% of all pediatric distal humerus fractures 2:1 males to female ratio Classificatio: Extension type: Extension type accounts for 90-98% of all supracondylar fractures Flexion type Galand Classification is commo...
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Ans- (Ulcerative lesion in the tonsil) (202-D) (87-LT)Ulcerative gingivitis - is a highly infectious and ulcerative lesion of the tonsils.It was common during the first world war, being called Trench mouth of Vincent's angina .
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b. Marasmus(Ref: Nelson's 20/e p 295-306> Ghai 8/e p 96-107)Clinical findingMarasmusEdemaAbsentActivityActiveAppetiteGood, VoraciousLiver enlargementAbsentMortalityLess than KwashiorkorRecoveryRecover earlySkin & hair changesLess common
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Ans. is 'a' small cell Ca of lung Small cell Ca of lung causes SIADH due to ectopic secretion of ADH.SyndromeSIADHChiefly associated withSmall cell lung Ca*Head & Neck cancer*Cushing's syndromeSmall cell lung Ca*Carcinoid Tumour*Hypercalcemia of malignancyNon-small cell lung Ca* (Squamous)Breast Cell*'Renal Ca Ca*Myelo...
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Ans. is 'a' i.e., Bone
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Cervical cancer is the most common genital tract malignancy in females in India Predisposing factors: Young age at first intercourse Multiple sexual paners Delivery of first baby before the age of 20yrs Multiparity with poor bih spacing between pregnancies Poor socio-economic status Sexually transmitted diseases and HI...
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(b) Fracture zygoma(Ref. Scott Brown, 8th ed., Vol 1; 1196)Enophthalmos can be present in fracture zygoma or blow out fracture of orbit.Fracture maxilla, i.e. Le Fort fracture are caused by high velocity injuries.Fracture nasal bone class 3, i.e. including ethmoid are also caused by high velocity injuries and will caus...
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Sclerosing osteomyelitis of Garre typically develops in the jaw and is associated with an extensive new bone formation that obscures much of the underlying osseous structure.
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Anterior interosseous aery pierces the interosseous membrane at the upper border of pronator quadratus to enter the extensor compament. Posterior interosseous aery passes through a gap above the interosseous membrane to the back of forearm . Anterior interosseous nerve is the branch of median nerve. Posterior interosse...
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Answer is D (Post streptococcal glomerulonephritis): While, IgA Nephropathy presents within three days, presentation of poststreptococcal GN is usually delayed to more than 10 days'.
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Medroxy progesterone acetate
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(ECTA) (41 7-Reddy 29th) (2.38, 7.7-Parikh 6th)DNA-FINGER PRINTINGIdentification of person by genetic analysis*** DNA is extacted from the nuclei of white blood cells or of spermatozones or of the hair follicles cells that cling to the roots of hair that have fallen, or been pulled.* DNA finger printing is based on var...
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Primary hyperparathyroidism is a disease characterized by excessive secretion of parathormone which results in increased osteoclastic activity therby causing bone loss . The bone loss predisoses to microfractures and secondary hemorrhages that elicit an influx of macrophages and an ingrowth of reparative fibrous tissue...
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Pulled elbow or Nursemaid's elbow occurs in children under 4 years old. It is caused by a sudden pull on the extended pronated arm, usually by an adult tugging on a reluctant toddler. The pronated radial head slips paially under the annular ligament and displaces into the radiocapitellar joint. The child suddenly stops...
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KROLL → “MICROABRASION technique“18%  HCl.  Indication of microabrasion:  Fluorosis stains/any stains–limited to depth, not more than 0.2 to 0.3 mm.
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Non-canalisation of nasolacrimal duct
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Ans. is 'c' i.e., HbF* Adult haemoglobin is made up of a2b2* Foetal haemoglobin is made up of a2g2* Adult haemoglobin undergoes denaturation in the presence of alkali to form alkaline hematin. Alkaline hematin is insoluble and precipitates.* On the contrary foetal haemoglobin is resistant to alkali denaturation.* This ...
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Calories are calculated by catabolism of glucose (not proteins) Glucose: Amount of glucose in 20% glucose in 3000 ml of solution: 3000*20/100 = 600 gms. 1 gm glucose on catabolism produces: 4.2 KCal. 600 gms of glucose would produce: 600*4.2 = 2520 KCal. Protein: Percentage of protein in fluid: 4.25% Percentage of prot...
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Ans. is 'a' i.e., Convex Presbvopia Presbyopia is a vision condition in which the crystalline lens of eye loses its flexibility, which make it difficult to focus on the objects closer to the eye. Presbyopia is not an error of refraction but a condition of physiological insufficiency of accommodation leading to a progre...
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Ans. is 'c' i.e., Capsular hyaluronic acid
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Given Abd X-ray - Coffee bean sign / Omega sign / Bent inner tube | Sigmoid volvulus TREATMENT:- Colonoscopic detorsion After 3 days sigmoid colectomy Ischemia / strangulation / perforation - Emergency condition | Immediate colonic resection
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(4 months) (43-Dutta 6th) (2154-Nelson 17th)* At 16th week (4 month) lanugo (downy thin colourless hairs) appears but near term almost completely disappears.The homy layer of epidermis is absent before 20th week.
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Milk contains calcium which Inhibits absorption of Iron by binding to Intestinal DMT-2 (Divalent Metal transpoer-2). Hence, iron tablets should never be taken with milk. Components impeding/ inhibiting iron absorption are: Phytates Tannates Oxalates Calcium Tetracycline. Vitamin C (ascorbic acid) is a facilitator of ir...
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This a case of phase II block, caused by a high dose of succinylcholine. "After administration of 7-10 mg/kg or 30-60 minutes of exposure to succinylcholine, non-deplarizing dual or phase II block occurs". — Millers Option a requires specific mention here because prolonged paralysis with succinylcholine administratio...
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In the olfactory bulbs, the axons of the olfactory sensory neurons contact the primary dendrites of the mitral cells and tufted cells to form anatomically discrete synaptic units called olfactory glomeruli. The olfactory bulbs also contain periglomerular cells, which are inhibitory neurons connecting one glomerulus to ...
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Ref: Robbins Pathologic Basis of Disease, 8th: editionExplanation:HASHIMOTO THYROIDITISMost common cause of hypothyroidism in areas of the world where iodine levels are sufficient. Gradual thyroid failure due to autoimmune destruction of the thyroid gland.Common age group (45 - 65)Female predominance (10: 1 to 20: 1)Ca...
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Ans. (b) Methenamine silver Ref. Ananthanarayan 8/e p 601; DR Arora 3/e 656 Stains for funp. Gomori methenamine silver (GMS) (Better contrast) Gridley fungus (GF) Periodic acid Schiff (PAS) Giemsa Alcian blue Meyer's mucicarmine Out of these GMS is the best stain for fungi. For studying tissue response secondary to fun...
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Ref BDC volume 3,6th edition pg 208NERVE SUPPLY:The superior oblique is supplied by trochlear nerveThe lateral rectus is supplied by abducent nerveThe superior rectus, medial rectus, inferior rectus and inferior oblique is supplied by occulomotor nerve
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Epinephrine markedly stimulates glycogen breakdown in muscle and, to a lesser extent, in the liver. The liver is more responsive to glucagon, a polypeptide hormone that is secreted by the a cells of the pancreas when the blood-sugar level is low Ref: guyton and hall textbook of medical physiology 12 edition page number...
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A i.e. Fine touchProprioceptive information is transmitted up the spinal cord in the dorsal columnQ. Majority of the proprioceptive input goes to the cerebellum but some passes to the coex also (conscious Propriocetion). There is some evidence that propioceptive information passes to consciousness in the antero-lateral...
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Renal tract anomalies coexist with Mullerian duct anomalies. Hence it is every case of congenital malformation of genital tract, it is wise to perform IVU to exclude urinary tract abnormalities.
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Lets have a look at each option: Option a: Stenosis of external os would result in hematometra, i.e. uterus would be large and non functioning (hence ruled out). Option c: Partial agenesis of vagina  In parital agenesis of vagina a segment of vagina may be atretic in the upper-third. It is often associated with hypopla...
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viral hemirrhagic fever caused by 2 families-Arenavirus and Filovirus.Filovirus invludes marburg anf ebola virus. REF:ANANTHANARAYAN AND PANIKER'S TEXTBOOK OF MICROBIOLOGY 9TH EDITION PAGE NO:558
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(B) 2 mg/kg > The dose of Propofol is 2-2.5 mg/kg for induction.> The lower dose should be used in the elderly.> The effective blood concentration for anaesthesia (ED 90 - the dose at which the effect is seen for 90% of patients) is 3.4 mg/mL when used with 67% nitrous oxide.> Sedation may be produced with a 0.2 mg/kg ...
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ganong's review of medical physiology 24th edition . *mesencephalic periaqueductal gray(PAG) is pa of descending pathway that modulates pain transmission by inhibition of primary afferent transmissiion in the dorsal horn of spinalcord *PAG neurons project directly to and activate two groups of neurons in brainstem:neur...
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The nohern blot is used to demonstrate specific RNA. The total RNA is isolated from the cell, electrophoresed and then blotted to a membrane. This is then probed with radioactive cDNA. There will be RNA-DNA hybridization, if the specific RNA is present in the cell. For DNA analysis southern blot technique is used, west...
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(A) B cell immunodeficiency # DiGeorge syndrome or 22q11.2 deletion syndrome, which has several presentations including DiGeorge syndrome (DGS), DiGeorge anomaly, velo-cardio-facial syndrome, Shprintzen syndrome, conotruncal anomaly face syndrome, Strong syndrome, congenital thymic aplasia, and thymic hypoplasia, is a ...
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.Gram -ve septicaemia is common in acute abdomen like peritonitis, abscess, urinary infections, biliary infections, postoperative sepsis. It is commonly seen in malnutrition, old age, diabetics, immunosuppressed people. Diabetic acute abdomen -Patient with diabetes mellitus may present as acute abdomen. Free fluid in t...
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Ans. (a) Phrenic nerveRef: Internet sourcesCauses of Diaphragm paralysis:* Neurological causes:# Phrenic nerve palsy# Motor neuron disease# Neuropathies# Myopathies* Viral infections* Tumors* Trauma* Surgical Operations
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Ans. b. Otoacoustic Emissions The screening investigation of high-risk neonates in ICU for suspected hearing loss is otoacoustic emissions. Uses of OAE Screening test of hearing in neonatesQ Help to differentiate between cochlear and retrocochlear lesionsQ Used to diagnose retrocochlear pathologies especially auditory ...
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Haematoma (not hamartoma) causes lung cavitation. Pulmonary infarct, squamous cell carcinoma of lung, RA & Caplan's syndrome can also cause lung cavitation.
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When a toxic amount of acetaminophen is ingested, the first two processes are overwhelmed and more acetaminophen is metabolized by the cytochrome P450 system to a hepatotoxic metabolite (N-acetyl-p-benzoquinoneimine, NAPQI). In therapeutic acetaminophen ingestions, the liver generates glutathione, which detoxifies NAPQ...
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B i.e. NinhydrinAmino acids can be detected and quantified by reaction with ninhydrin after seperation of amino acid from mixtures. The test requires intact peptide bondsQ.
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Answer is D (Aoic Dissection) Aoic Dissection is not a known cause for digital clubbing: Digital clubbing results from long standing conditions that take months to develop. It is not associated with acute event like aoic dissection Cardiovascular causes of Digital clubbing (Ultra medicine (2005)/285) Subacute Bacterial...
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Infectious mononucleosis is a benign lymphoproliferative disorder caused by infection with the Epstein-Barr virus (EBV). It typically occurs in young adults and presents with systemic symptoms, lymphadenopathy, and pharyngitis. Hepatosplenomegaly may be present. Peripheral blood shows an absolute lymphocytosis, and man...
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Occurs due to the retina being pushed away by a neoplasm or accumulation of fluid beneath the retina following inflammatory or vascular lesions. Etiology: Systemic diseases- toxaemia of pregnancy, retinal HTN, blood dyscrasias. Ocular diseases- scleritis, central serous retinopathy, orbital cellulitis, retinoblastoma, ...
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Hypoventilation always causes both hypoxemia and hypercapnia. If the hypoventilation syndrome is caused exclusively by impaired respiratory drive (e.g., drug overdose), then the alveolar-arterial PaO2 gradient remains normal. Often, hypoventilation results from more than one disorder in the respiratory system (e.g., CO...
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In a DNA double helix, two polynucleotide strands come together through complementary pairing of the bases, which occurs by hydrogen bonding.Each base forms hydrogen bonds readily to only one other -- A to T and C to G -- so that the identity of the base on one strand dictates what base must face it on the opposing str...
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Rickets is characterized by the continued formation of the collagen matrix of bone, but incomplete mineralization results in soft, pliable bones.  In osteomalacia, demineralization of pre-existing bones increases their susceptibility to fracture. Insufficient exposure to daylight and/or deficiencies in vitamin D consum...
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Queckenstedt maneuver IJV: Venous outflow Brain | ICP: Patent subarachnoid space i.e. no spinal block present If presence of sagittal vein thrombosis/spinal block then this maneuver will not increase in the pressure of manometer reading because entire circuit is blocked. Queckenstedt or Tobey- Ayer test: Compression of...
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Ans. is 'c' i.e., Epididymis Spermatozoa leaving the testis (seminiferous ubules) are not fully mobile. They continue their maturation and acquire their mobility during their passage through epididymis. From epididymis they come to vas deference, distal end of which also receives the secretions of seminal vesicle, and ...
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