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Many chemicals can, when properly used, significantly contribute to the improvement of our quality of life, health and well-being. But other chemicals are highly hazardous and can negatively affect our health and environment when improperly managed.10 chemicals or groups of chemicals of major public health concern are:...
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Earliest sign of fetal compromise is a raised S/D ratio in the Umblical aery flow. An absence of diastolic flow is indicative of severe fetal compromise and requires intensive fetal monitoring with NST and frequent doppler upto 34 weeks or occurence of reversal of flow (whichever is earlier) after which pregnancy shoul...
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Ans. is 'a' i.e., 4 - 8 O'clock Hymen Hymen is a thin, firm fold of mucous membrane present at vaginal orifice. It usually has one opening, which hardly admits the tip of the little finger in a virgin. Hymen is like a tight stretched membrane. The usual shape is annular or semilunar, that is, cresentric with the broade...
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(A) Dilated ventricle # Hypertrophic cardiomyopathy (HCM) is characterized by LV hypertrophy, typically of a nondilated chamber, without obvious cause, such as hypertension or aortic stenosis.> It is found in about 1 in 500 of the general population. Two features of HCM have attracted the greatest attention: Asymmetric...
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C i.e. Inferior frontal lobe
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Ans. (a) Vibrio cholerae Cholera toxin (CT) Protein enterotoxin Composed of 2 subunit: A - (Active monomeric moiety) B - (Pentameric binding moiety) Mechanism of action: The B-pentamer binds to GM, ganglioside, a glycolipid on the surface of epithelial cells that serves as toxin receptor | The activated A subunit (A,) ...
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Ans. d (Nd- YAG Laser). (Ref: Ophthalmology by A K Khurana 2nd ed: 209)LASERNd-YAG USER# Thin membranous after cataract and thickened posterior capsule are best treated by YAG laser capsulotomy or discission with cystotome or Ziegler's knife.# Nd-YAG produces an infrared radiation with a wavelength of 1064nm.He-Ne LASE...
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B i.e. Barbiturate
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Imprint abrasion Real confusion in this question is between imprint abrasion and patterned bruising. In both imprint abrasion and patterned brusing there is mark or pattern of the object causing injury. Abrasion is caused by friction and/or pressure between the skin and some rough object or surface. For abrasions to oc...
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Ans. (d) MedullaryRef: Schwartz 10th edition, Page 1550* FNAC showing Amyloid Stroma.* Can be asked as a Picture Based question
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Atherogenesis is the developmental process of atheromatous plaques. It is characterized by a remodeling of aeries leading to subendothelial accumulation of fatty substances called plaques. The buildup of an atheromatous plaque is a slow process, developed over a period of several years through a complex series of cellu...
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Type II Collagen is the major collagen in cartilage. Type I is the major collagen in Bone, Dermis, ligaments and tendons.
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"The number of positive nodes appeared to be the single most important prognostic factor."-DeVita
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Ans is 'a' ie left lumbar vein (Ref. BDC (vol II), 3/e, p 272)Tributaries of left renal veinLeft gonadal veinLeft suprarenal veinLeft inferior phrenic veinOn right side they open directly into the inferior vena cava.
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Atosiban is oxytocin antagonist and best tocolytic in cardiac patients. B agonists and Calcium channel blockers are contraindicated in hea disease complicated pregnancies.
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Ans. is 'a' i.e., Failure of obliteration of second branchial cleft Brachial Cyst* A branchial cleft cyst is a congenital epithelial cyst that arises on the lateral part of the neck usually due to failure of obliteration of the second branchial cleft in embryonic development. Less commonly, the cysts can develop from t...
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D. i.e. (4 years) (4 Ghai 6th) (6 - Ghai 7th)WeightLength or heightHead circumference*birth - about =3 kg*birth50 cm*Birth34 cm5 month(Doubles)6 kg1 years75 cm1 years45 cm1 years9 kg2years85 cm2years47 cm2 years12 kg3 years95 cm 3 years14 kg4 years(doubles)100 cm3 years49 cm4 years16 kg 4 years50 cm* A useful guide for...
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Ans. b. AcamprosateAnticraving drug given in alcohol dependence is Acamprosate.Treatment of Alcohol DependenceAversion therapy: ApomorphineQ, sub-threshold electric shockPsychotherapyGroup therapyDeterrent agents: (Alcohol sensitizing drugs)QDisulfiramQCitrated calcium carbimide (CCC)Metronidazole, NitrafezoleQMethylte...
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Severe malaria is indicated by Hyperparasitaemia (>5% parasitized RBCs in low endemic and >10% in hyperendemic areas) Ref:
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Answer- A. Dequern's thyroiditisDequervain thyroidits (granulomatous thyoiditis) - Most common cause of thyroid pain.
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d. Ascorbic acid(Ref: Nelson's 20/e p 2323-2325, Ghai 8/e p 334-335)Iron Absorption* Site of iron absorption: duodenum and upper jejunum; Ferrous form (Fe2+) of iron is absorbedQ* Transport of (Fe2+) into enterocyte occurs via DMT1Q Increased byDecreased by* Acids e.g. ascorbic acid (Vitamin C)Q* Amino acid containing ...
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Answer is C (Anticoagulant therapy): D-Dimer values are falsely decreased in patients receiving anticoagulant therapy -Clinical Hematology Myocardial infarction, pneumonia and pregnancy are all established causes for false positive (Elevated) D-Dimer values Elevated True Positive Thromboembolic Diseases * PE * DVT * DI...
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Streptococcus agalactiae is a group B hemolytic streptococci. They are normal flora of the female genital tract and an impoant cause of neonatal sepsis and meningitis. They hydolyze sodium hippucrate, typically beta hemolytic, gives a positive response to cAMP (Christie, Atkins and Munch-Peterson) and resistant to baci...
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.Lithotomy position used for all perineal surgeries like for fissure, piles, fistula, and APR. ref:SRB&;s manual of surgery,ed 3,pg no 913
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Chloroquine
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ref : schwaz 9e p570
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It ferments Maltose
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Investigation of choice for motor disorders (including diffuse esophageal spasm) is esophageal manometry.
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.Paralytic ileus is the commonest complicationof typhoid. 2. Intestinal haemorrhage--as the Peyer's patches in terminal ileum are enlarged and ulcerated - 10%. 3. Perforation usually occurs in 3rd week of the infection. Ulcers are multiple, arranged in parallel and in antimesenteric border of the ileum. One or more ulc...
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Ans. is 'c' i.e., Mgo Mg2+ is required in stage 2 of cholesterol synthesis.Biosynthesis (De Novo Synthesis) of cholesterolo The liver is the major site for cholesterol biosynthesis. Some cholesterol is also synthesized in intestine adrenal cortex, gonads and skin. The microsomal (smooth endoplasmic reticulum) and cytos...
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A i.e. Gallamine
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Radiation Effects Stochastic Deterministic (Non - stochastic) 1. They are not dose dependent 1. They are dose dependent 2. They have no threshold 2. They have a threshold 3. They can occur at low doses 3. They occur at high doses above threshold 4. Severity of effect is not related to dose, but probability of occurrenc...
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(B) 4 AM and 10 AM # ACTH the primary stimulator of adrenal cortisol production is synthesized by pituitary in response to CRH, which is released by hypothalamus.> Plasma ACTH and cortisol levels exhibit peaks at 6-8 AM and nadirs at 11 PM.> Referene values: 10-60 pg for AM values. No established reference values for P...
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Ans is 'd' i.e. Low prevalence "In a population with a low prevalence of a particular disease, it is likely that most of the positive results in a screening program for that disease would be falsely positive."- Epidemiology, biostatistics, and preventive medicine By James F. Jekel, David L. Katz, Joann G. Elmore 2/e p1...
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ANSWER: (D) Compression fractureREF: Manual of orthopedics by Marc F. Swiontkowski MD 6th ed Ch: 7Burst Compression fractures of the lumbar spine are associated with fractures of calcaneus in a setting where a person falls and land on foot. This type of fracture is called a Don Juan fracture.Calcaneal fractures are mor...
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Ans. is 'd' i.e., Clonorchis sinensis Parasites with a complex life cycle with three hosts Parasite Definitive fi Host H De First Inter- mediate host Second inter- mediate host Cestodes Diphyllobothrium Human beings, animals Cyclops Fish Trematodes Opisthorchis sinensis Human beings, animals Snails Fish Paragonimus wes...
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Oxidation of fatty acid - two pathway Major pathway - beta oxidation -oxidation of fatty acid at beta carbon atom and sequential removal of acetyl COA MINOR PATHWAY - a oxidation and o oxidation Refsum disease - Defect in the alpha-oxidation due to the deficiency of the enzyme phytanic acid alpha-oxidase. Phytanic acid...
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Superior constrictor MUSCLE Superior constrictor (Constrictor of pharynx) ORIGIN i. Pterygoid hamulus ii. Pterygomandibular raphe iii. Medial surface of mandible (near lower attachment of pterygomandibular raphe INSEION Median raphe on posterior wall of pharynx Inferior constrictor (Constrictor of Two pas: pharynx) i. ...
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After branching from the mandibular nerve (CN V3), the auriculotemporal nerve travels posteriorly and encircles the middle meningeal artery, remaining posterior and medial to the condyle. It then continues up towards the TMJ,external ear, and temporal region, passing through the parotid gland and traveling with the sup...
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- Inflammation of lacrimal sac - Dacryocystitis - In congenital dacryocystitis, most common site of obstruction is lower end of nasolacrimal duct, usually near valve of Hasner. CONGENITAL DACRYOCYSTITIS :- Occurs in approximately 5% of normal newborn infants.- Rate of spontaneous resolution is upto 90%- Presents with e...
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Hair on end appearance is characteristically and most commonly seen in thalassemia because marrow hyperplasia is more marked in this than other anemia. Sickle cell anemia is the 2nd most common cause (after thalassemia).
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Difficulty in communication, delayed speech, obsessiveness and problems in forming social relatonships in early childhood suggests the diagnosis of autism. The triad of autism include communication difficulties, repetitive or obsessional behaviours and difficulties in social interactions. Ref: Essentials of Pediatrics ...
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Ans. is 'a' i.e., Hypothyroidism causes delayed dentition; 'b' i.e., Premolar is not seen in primary dentition; 'c' i.e., 3rd molar is the last to appear in secondary dentition
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Isolated hematuria is usually of urologic cause (e.g., tumor, trauma, stone) but can also be glomerular in origin. The finding of red cell casts or dysmorphic red cells (best appreciated by phase microscopy) suggests the source of bleeding is glomerular in origin.
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In COPD the FEV1 and VC are reduced, but the FEV1 is reduced more because of high airway resistance resulting in a decreased FEV1/FVC ratio. The hallmark of COPD is airway obstruction (FEV1/FVC < 70%) that is not reversible with salbutamol. In predominant emphysema, diffusing capacity is more profoundly decreased than ...
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Among the given options, slow waves are maximum in the ileum. The rate of slow waves in ileum is 8/min. Slow waves or Basic Electric rhythm(BER) refers to the spontaneous rhythmic fluctuation in membrane potential of the GI smooth muscles (betwee -65mV and -45mV). These are initiated by the interstitial cells of Cajal....
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Ans. All of the above
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Ans. (a) Type A fiber(Ref: Ganong, 25th ed/p.94)Erlanger and Gasser classified nerve fibers in to three types A, B and C based on their diameter, degree of myelination and conduction velocities.The classification is for both sensory and motor nerve fibers. The classification is as follows,Fiber TypeMyelin Present or Ab...
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Answer is A (Recurrent Hemahrosis): Recurrent Hemahrosis is the most common manifestation of Hemophilia A. 'Recurrent Hemahrosis is the most common manifestation of Hemophilia-A occurring in up to two third of patients' --Primer on the Rheumatic Diseases 'In the severe form the most common bleeding manifestations are t...
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Centriacinar emphysema Destruction and enlargement of the central or proximal parts of acinus with sparing of distal alveoli. Most common type emphysema. Upper lobe and apices are predominant involvement. Commonly seen in heavy smokers and chronic bronchitis.
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VIRUS contain a single type of nucleic acid, i.e., either DNA or RNA, but not both. Bacteria and fungi contain both DNA and RNA. Spirochetes are bacteria.
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The sensory root is from the lingual nerve. It is suspended by two roots of lingual nerve.The sympathetic root is from the sympathetic plexus around the facial aery. This plexus contains postganglionic fibers from the superior cervical ganglion of the sympathetic trunk. These fibers pass express through the ganglion an...
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risk factors of gall stone A) advancing age B)female sex hormone C) obesity D)acquierd disorders such as gallblader stasis E)hereditory factor F)metabolic abnormality such as DM, hyperlipidemia and PBC GENERAL AND SYSTEMIC PATHOLOGY RAMDAS NAYAK PGNO.475
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Ans. (a) Intralesional injection of keloid(Ref: Bailey 26/e p30)Treatment of keloids and Hypertrophic scars:* Intra lesional Triamcinolone acetate* Local pressure* Intra lesional excision done only for keloids.* Laser to reduce redness.* Vitamin E or Palm Massage oil.* Silicone gel sheeting* Excision and Steroid Inject...
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Glaister Keen rod is used for close examination of the hymen or the degree of its rupture. Ref - Krishan Vij 5th edition pg 314
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Fundus of stomachPercussion for splenomegaly: The normal human spleen measures about 125 millimeters in length, and splenomegaly is an impoant clinical sign.There are 2 possibilities to evaluate splenomegaly in the clinical examination: percussion and palpation. Percussion can be done in this space.Beneath Traube's spa...
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Ans. A. Internal carotid arteryThe anterior choroidal artery originates from the internal carotid artery.The internal carotid artery is located in the inner side of the neck in contrast to the external carotid artery. In human anatomy, they arise from the common carotid arteries where these bifurcate into the internal ...
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Causes of hemorrhagic pericarditis 1. Tuberculosis 2. Malignant involvement of pericardial sac 3. Bleeding diathesis 4. Cardiac surgery 5. Post-myocardial infarction 6. Dissecting aneurysm of aorta 7. Uremic pericarditis
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Ans. D i.e. Hypokalemia Succinylcholine/ SCh Depolarizing muscle relaxant, Shoest acting depolarizing MR; Shoest acting MR Dual/ biphasic block, Rapidly hydrolyzed by pseudocholinesterase Pressure increased by SCh: - Intra-cranial pressure, - Intra-ocular pressure, - Intra-gastric pressure SCh causes: - Muscle pain, - ...
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Ans: A (Heart) Ref: The Essentials of Forensic Medicine and Toxicology by KS Narayan Reddy. 29th edition. 2010Explanation:Rigor MortisThis is the state of stiffening and sometimes shortening of muscles following deathIt occurs due to lack of ATP after birth.When the ATP is reduced to a critical levels of 85% of normal,...
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Ans. (b) PneumococcusRef: Microbiology by Ananthanarayan and Paniker 8th ed. 119, 63, 193* Due to alpha hemolysis, colonies of pneumococci resemble colonies of Str. viridans.* On further incubation the colonies of pneumococci become flat with raised edges and central umbonation, so that concentric rings are seen on the...
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The rabies virus is a bullet-shaped virion with a single-stranded ribonucleic acid (RNA) nucleocapsid core and lipoprotein envelope. Its nucleocapsid material consists of Negri bodies, which are observed in the cytoplasm of infected neurons (see the image below). The virus is transmitted in saliva or in aerosolized sec...
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Tretinoin is a cancer medication used to treat acute promyelocytic leukemia Acute Promyelocytic Leukemia For use in patients with APL classification M3, which is characterized by the presence of t(15;17) translocation and/or the presence of the PML/RAR-alpha gene, who are refractory to, or have relapsed from, anthracyc...
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Caroli's disease Clinical features : Symptoms include cholangitis (64%), poal hypeension (22%) and abdominal pain(18%) More common in males Septa containing poal veins protrude into the lumen of the ecstatic bile ducts (central dot sign) The main and often the only symptom of bacterial cholangitis secondary to caroli's...
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Leucocytoclastic vasculitis- It is a cutaneous acute vasculitis characterized clinically by palpable purpura especially of the legs and histologically by the presence of leucocytoclasts (Leucocytoclasts are nuclear debris of neutrophils) Causes of leucocytoclastic vasculitis: - Drug-induced vasculitis    Henoch scho...
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Ans: a (Below ) Ref: Cltaurasia, 4th ed, p. 79The shoulder joint is weakest interiorly. It is more prone to dislocation than any other joint.Dislocation usually occurs when the arm is kept in an abducted position.The stability of the shoulder joint is provided in part by the rotator cuff all around. It is made of the S...
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D i.e. 18FDG PET Scan - 18 FDG-PET scan detects cerebral metabolism and is used for tumor grading, estimation of prognosis, localization of optimal biopsy site (most malignant areas show maximum F18 fluoro-deoxy-glucose uptake), assessment of response to therapy and detection of recurrence (versus radionecrosis)Q in br...
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The deoxygenated subunits of the hemoglobin tetramer exist in the T ("tense") conformational state. As erythrocytes enter the capillaries of the lung alveoli, the paial pressure of O2 has increased sufficiently to allow binding to hemoglobin. When one mole of O2 binds, it causes a shift in the overall conformation of t...
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Lung cancer -- Approximately 2 to 4 percent of patients with lung cancer develop SVC syndrome at some point during their disease course SVC syndrome is more common with SCLC, occurring in approximately 10 percent of cases at presentation . This is presumably because SCLC develops and grows rapidly in central, rather th...
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Where it enters the pelvis
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Ans is 'b' i.e., Wrist Radiograph used to determine skeletal age o 3-9 months --> Shoulder o 1-13 years --> Hand and wrist o 12-14 years --> Elbow and hip
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Feature of aificial bruising is given below: 1) Seen on exposed easily accessible pas 2) Dark brown in colour 3) Well defined wound covered with vesicles 4) Inflammation around the surrounding site 5) Itching 6) Vesicles on the fingeip and other pas of the body due to scratching Note: Aificial bruises can be caused by ...
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Reefer - CANNABIS Smack - HEROIN Speedball - COCAINE AND HEROIN Ecstacy - MDMA
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B i.e. Best Disease Best disease & vitelliform dystrophy occurs d/t mutation of bestrophin (VMD2) gene on 11q13 chromosome and has autosomal dominant inheritence (AD)Q. It has lipofuscin accumulation through out the RPE. It is typified by a large yellow yolk like (vitelliform) lesion giving characteristic egg yolk appe...
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Ans. is 'b' i.e., Vibrio parahemolyticus Bipolar staining (safety pin appearance)o Some bacteria display a safety pin appearance due to the accumulation of dye at the poles of the cells,o This characteristic is called bipolar staining.o Bacteria showing bipolar staining are-1. Caiymmatobacter granulomatis (Donovani gra...
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ANSWER: (C) 1-3REF: Park 20th ed p. 636Drinking water should be moderately hard. Softening of drinking water Is recommended when the hardness exceeds 3 mEq/LClassificationLevel of hardness ( mEq/L)Soft water< 1 ( < 50 mg/l)Moderately hard1-3 ( 50-150 mg/l )Hard water3-6 (150-300 mg/l)Very hard water> 6 ( > 300 mg/l)
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Ans. is 'c' i.e., Semple Vaccine Rabies Vaccine . Rabies vaccines are fluid or dried prepration of fixed virus grown in the neural tissues of rabbits, sheep, goats, mice or rats or in embryonated ducks egg or in cell cultures. . Inactivation of virus is commonly done by treatment with formalin or R. Propiolactone (B.P....
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Ans. (B) Hyperkalemia(Ref: Katzung 11th/e p460)Succinylcholine can cause hyperkalemia especially in patients with nerve and muscle disorders. Therefore it is contra-indicated in patients with nerve diseases (like paraplegia, hemiplegia and Guillain barre syndrome) and muscle diseases (muscular dystrophy, myasthenia gra...
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Reverse split S2 implies aoic valve closes very late to a level that it closes after the pulmonary valve closure (Normally aoic valve closes first and then pulmonic valve). Severe aoic stenosis -Valvular obstruction makes the work of left ventricle harder. The longer ejection time leads to delayed closure of aoic valve...
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Whipples operation (Pancreaticoduodenectomy) is the most commonly performed operation for carcinoma of head of pancreas. It includes resection of: - distal stomach - duodenum - gall bladder - proximal jejunum - CBD - regional lymphatics - head of pancreas Restoration of gastrointestinal continuity requires - pancreatic...
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In case of intermittent upper GI bleeding for which no source has been found endoscopically or radiologically, laparotomy is done to see any missed common cause or angiodysplasia or for any obscure causes. SRB edition 5th page no .992
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Aoic regurgitation Valvular Congenital (bicuspid) Endocarditis Rheumatic fever Myxomatous (prolapse) Traumatic Syphilis Ankylosing spondylitis Root disease Aoic dissection Cystic medial degeneration Marfan's syndrome Bicuspid aoic valve Nonsyndromic familial aneurysm Aoitis Hypeension ( Harrison&;s principle of interna...
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Turner syndrome (gonadal dygenesis) is the most common cause of primary amenorrhea. In patients of Mullerian agenesis the karyotype is 46 XX. Whereas in testicular feminization syndrome (androgen insensitivity syndrome) it is 46 XY. Laparoscopy will reveal absent uterus in both the cases but in Mullerian agenesis there...
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In the synthesis of Norepinephrine, Tyrosine is hydroxylated to 3,4dihydroxyphenylalanine by tyrosine hydroxylase. This enzyme catalyses the rate limiting reaction and require tetrahydrobiopterin as coenzyme.Ref: Biochemistry, U. Satyanarayana, Fouh edition, page no: 349
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Ans. is b, i.e. Obstetric conjugateRef. Dutta Obs. 9/e, p 80-81Anteroposterior diameters of the pelvic inlet.DiametersFeatureMeasurement IObstetric conjugate* It is the distance between the midpoint of the sacral promontory to prominent bony projection in the midline on the inner surface of the symphysis pubis.* It is ...
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- This is the first step of base excision repair. Bases modified by deamination, methylation, or by other chemical modification are removed by this kind of repair system.
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People living with RHD need to be on medication to reduce the risk of blood clots which can cause stroke. Medication may be needed if you have a hea valve replacement operation or an abnormal hea rhythm (atrial fibrillation). The most common anticoagulation medicine is called warfarin An INR range of 2.0 to 3.0 is gene...
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Pulmonary sequestration is nonfunctional pulmonary tissue that does not communicate with the tracheobronchial tree and receives its blood supply from one or more anomalous systemic aeries. This abnormality originates during the embryonic period of lung development. It is classified as either extralobar or intralobar.Ex...
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Popliteus rotates the tibia medially on the femur or, when the tibia is fixed, rotates the femur laterally on the tibia. At the beginning of flexion of the fully extended knee, lateral femoral rotation by popliteus muscle unlocks the joint.Must know:Locking of knee joint is due to the the action of quadriceps femoris, ...
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Green house gases Water vapour (Highest contribution) Carbon dioxide (second highest contribution) Methane Ozone: Ozone later is beneficial as it cuts down IV transmission CFC's depletes ozone layer Ref : Wikipedia
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Cephalohematoma cranial subperiosteal hematomas cause is prolonged second stage of labour or instrumental delivery develop from shearing forces during labor and delivery that lacerate the emissary or diploic veins, the densely adhered periosteum impedes rapid enlargement and limits final hematoma size. does not cross s...
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.Ans. (c) Beating on both earsRef: Reddy 5th ed. / 257
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Insulin is a peptide hormone, produced by beta cells of the pancreas, and is central to regulating carbohydrate and fat metabolism in the body. Insulin causes cells in the liver, skeletal muscles, and fat tissue to absorb glucose from the blood. In the liver and skeletal muscles, glucose is stored as glycogen, and in f...
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Design of the major connector must be determined during diagnostic and treatment planning phase, because mouth preparation procedures depend in part on the contemplated design of major connectors.
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Ganer's duct cyst arises from incomplete regression of the vaginal poion of the Wolffian (mesonephric) ducts. Ganer's ducts are determined by the presence of persistent remnants of mesonephric ducts. Since the mesonephric ducts have secretory propeies, cysts can develop. Usually, cysts located along the anterior-latera...
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Ans. a. Coats' disease
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Central nervous system involvement is one of the most prominent clinical manifestations in APLAS.
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Ans. is 'b' i.e. procaineThis one has been repeated so many times beforeAmide linked Local anaestheticsLidocaineBupivacaineDibucainePrilocaineRopivacaineEster linked local anaestheticsCocaineProcaineChlorprocaineTetracaineBenzocaine
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Atypical lymphocytosis -points diagnosis towards Infectious mononucleosis (EBV) (kissing disease) among the given other options. Essentials of Diagnosis Malaise, fever, and (exudative) sore throat Palatal petechiae, lymphadenopathy, splenomegaly, and, occasionally, a maculopapular rash Positive heterophile agglutinatio...
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