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135
2b914563-e45e-4c5b-a956-898049c68022
"Pseudopalisading" arrangement of malignant cells is characteristic of:
Glioblastoma
Ependymoma
Oligodendroglioma
Medulloblastoma
0a
single
"The highest grade tumor of astrocytoma, known as glioblastoma, has a histologic appearance similar to anaplastic astrocytoma with the additional features of necrosis and vascular or endothelial cell proliferation and pseudo-palisading nuclei." Glioblastoma is type of infiltrating astrocytoma (Classified as Grade 4). ...
Pathology
null
9ff1b39e-3523-4c43-aeb4-2e8190f093bd
Steeple sign is seen in
Croup
Acute epiglottitis
Laryngomalacia
Quinsy
0a
single
Acute laryngotracheobronchitis or croup is a viral infection caused by parainfluenza type 1, 2, and sometimes 3. The critical area involved is subglottic larynx producing oedema with stridor and respiratory distress. X-ray (PA view) larynx shows typical "steeple sign" but X-rays are avoided as any manipulation may prec...
ENT
Larynx
f5e1e31e-64d3-4a5c-b114-9bfb94f5a0d2
SIADH is caused by all EXCEPT :
Vincristine
Vinblastine
Actinomycin D
Cyclophosphamide
2c
multi
Drugs causing syndrome of inappropriate ADH (SIADH) secretion
Pharmacology
null
5ff1c598-70b9-41c8-a40d-7b1c13390466
VHL gene is located on?
3q
3p
5p
5q
1b
single
VHL gene mutation is associated with neurocutaneous syndrome Von - Hipple - Lindau disease. It is associated with Hemangioblastomas, cysts, Renal cell carcinoma.
Pathology
null
3da47ba9-a983-4103-8f18-96f71db8460c
Cetuximab (an EGFR antagonist) can be used in ?
Palliation in head and neck cancer
Anal canal ca
Gastric ca
Lung ca
0a
multi
Ans. is 'a' i.e., Palliation in head neck cancer Uses of Cetuximab Head and neck cancer Colorectal cancer
Pharmacology
null
5e9d17bb-fb95-4fd5-94c7-762219f408c1
Causes of papillary necrosis in kidney are/is:
Diabetes mellitus
Sickle cell disease
Analgesic abuse
All
3d
multi
Ans. d (All). (Ref. Robbin's, Pathology, 6th/pg.924)CAUSES OF PAPILLARY NECROSIS (mnemonic--POSTCARD):# Pyelonephritis# Obstructive uropathy# Sickle cell disease# TB and trauma, tubular necrosis, transplant rejection# Cirrhosis (alcoholism, coagulopathy)# Analgesics# Renal vein thrombosis# Diabetes, Dehydration
Pathology
Kidney
521095cd-26b7-45ad-b688-2d2355415336
'Heliotrope rash' over face is seen in
Systemic sclerosis
Dermatomyositis
Systemic lupus erythematosus
Rheumatoid ahritis
1b
single
Dermatomyositis a. Heliotrope erythema and oedema of the periorbital skin are seen in dermatomyositis, b. Dermatomyositis is a well established cutaneous marker of interval malignancy. c. About 10% of all patients of dermatomyositis have an underlying malignancy. d. The most common malignancies associated with dermatom...
Physiology
All India exam
af8ff85b-628f-408c-ab77-7b685db30837
Hypeension in childhood typically complicates
Post-streptococcal glomerulonephritis
Minimal change disease
Appendicitis
Peptic ulceration
0a
multi
Hypeension complicates 60-70% of post-streptococcal glomerulonephritis and it can result in cardiac failure and hypeensive encephalopathy.Post-streptococcal glomerulonephritis- Labile Hypeension as it resolves within 4-6 weeks of onset.In minimal change nephrotic syndrome, hypeension is absent.PSGN occurs 1-3 weeks fol...
Pediatrics
All India exam
35c1ba74-e05e-4e96-9772-6c7b74e3d588
29-year-old male with episodic abdominal pain and stress-induced edema of the lips, the tongue, and occasionally the larynx is likely to have low functional or absolute levels of which of the following proteins?
C5A (Complement cascade)
T cell receptor, a chain
Cyclooxygenase
C1 esterase inhibitor
3d
multi
Complement activity, which results from the sequential interaction of a large number of plasma and cell-membrane proteins, plays an impoant role in the inflammatory response. The classic pathway of complement activation is initiated by an antibody-antigen interaction. The first complement component (C1, a complex compo...
Biochemistry
null
6e1702ad-dfeb-4274-95de-052628a319d6
Colonic Polyp that has maximum chance of malignant change?
Hyperplastic polyp
Adenomatous polyp
Juvenile polyp
Polyp of Peutzeger syndrome
1b
single
Ans. B. Adenomatous polyp.. (Ref. Robbin's pathology 8th/pg. 618)Robbin's pathology 8th/pg. 618....."Adenomas are neoplastic polyps that range from small, often pedunculated, tumors to large lesions that are usually sessile. Incidence of adenomas in the small intestine is very low compared to those arise in the colon.T...
Pathology
G.I.T.
96c23a4f-3ee1-41ea-91b8-79bdb6ce6df3
13, years old boy, the LEAST common cause of proximal lytic lesion of the head of the femur is -
Plasmacytoma
Metastasis
Histiocytosis
Bone tumour
0a
single
If multiple myeloma occurs as a solitary lesion it is known as Plasmacytoma Age gp is 6th-7th decade, Rare before 40yrs of age So the lytic lesion in a 13 yrs old boy cannot be a plasmacytoma
Orthopaedics
null
5672e9f4-7e9a-40bf-8d7e-477f6823bccf
Venous drainage from neurohypophysis is routed through all of the following except -
Portal vessels to adenohypophysis
Superior hypophyseal veins to ventricular tanycytes
Inferior hypophyseal veins to dural venous sinuses
Capillaries to median eminence and hypothalamus
1b
multi
There are three routes for venous drainage of neurohypophysis :- To adenohypophysis via long and short portal vessels. Into dural venous sinuses via inferior hypophyseal veins. To hypothalamus via capillaries passing to median eminence.
Anatomy
null
f8227ae2-5dc5-4922-b2fa-e27fb5306691
Which orexin receptor antagonist is approved for treatment of insomnia ?
Suvorexant
Doxepin
Ritanserin
Agomelatine
0a
single
Suvorexant MOA : Orexin 1 and 2 receptors inhibitor Orexin antagonist enhance REM and non-REM sleep. Suvorexant decreases sleep onset latency Dose : 10-mg dose within 30 min of going to bed S/E : Daytime somnolence
Pharmacology
Sedative-Hypnotics and Parkinsonism
2c2932a5-7d82-451b-9734-67a5c7499fa1
Contraindication of induction of labour among the following is
Contracted pelvis
Bad obstetrical history
Diabetes
Hea disease
0a
single
Methods to induce or augment labor are contraindicated by most conditions that preclude spontaneous labor or delivery. The few maternal contraindications are related toPrior uterine incisionType contracted or distoed pelvic anatomy,Abnormally implanted placentas, and Uncommon conditions such as active genital herpes in...
Gynaecology & Obstetrics
General obstetrics
63bf9364-0226-4f29-9b77-de17ef6e2c7d
Contraindication for applying forceps: March 2009
Crowning of head
Head station +1
Maternal cardiac disease
CPD
3d
single
Ans. D: CPDMnemonic for FORCEPS:Favourable head position and station Open os (fully dilated)Ruptured membranesContractions present and Consent Engaged head, Empty bladderPelvimetry-no major CPDStirrups, lithotomy positionThe following are contraindications to forceps-assisted vaginal deliveries:Any contraindication to ...
Gynaecology & Obstetrics
null
fa74cf8e-6c89-4000-8191-4b335f9376ad
Peau d’orange appearance is due to -
Intra-epithelial cancer
Sub-epidermal cancer
Lymphatic permeation
Vascular embolization
2c
single
Phenomena resulting from lymphatic obstruction in advanced breast cancer 1. Peaud* orange  Peau d' orange is due to cutaneous lymphatic edema, where the infiltrated skin is tethered by the sweat ducts, it cannot swell, leading to an appearance like orange skin. Occasionally it may be seen in a chronic abscess.  2. Canc...
Surgery
null
e9a5635b-3345-4dca-856b-6d756002c379
Periodontal diseases associated with neutrophil disorders include
Acute necrotizing ulcerative gingivitis
Localized juvenile periodontitis
Rapidly progressive periodontitis
All the above
3d
multi
null
Dental
null
d1e0bec3-88b2-4e94-ac57-57e1015bcade
A 30 year old, para two, with two live children has menorrhagia for 2 years. She was ligated 4 years back. On investigation she is found to have a 2 cm X 2 cm submucous myoma. What will be the best management option for her :
Total abdominal hysterectomy
Danazol 400mg twice daily for 3 months
Gn RH analogues
Hysteroscopic myoma resection
0a
multi
Total abdominal hysterectomy
Gynaecology & Obstetrics
null
9e918ba4-23b3-4379-a5f6-b40516007d6b
Which of the following drug is used for hyperkalemia?
Calcium gluconate
Glucagon
Sodium phosphate
Chloride salts
0a
single
Calcium gluconate is used to decrease potassium toxicity along with insulin. Calcium chloride is 2nd choiceRef:
Pharmacology
General pharmacology
ec337e61-0883-4ab3-aa51-636b30ac89aa
Purtscher retinopathy is seen in patients with -
Complication of chronic pancreatitis
Occlusion of anterior retinal artery
Head trauma
Diabetes mellitus
2c
single
Ans. is 'c' i.e., Head trauma Purtscher retinopathyo Occurrence of bilateral patches of retinal whitening and hemorrhage around the optic disc in patients who suffered massive head trauma was first described by Purtscher and is called Purtscher retinopathy.
Ophthalmology
Traumatic Lesions
87d78d59-f6b7-4c80-ba5e-62a466fe9428
Radial Keratoneuritis is seen in
Acanthamoeba
Herpes-simplex
Neuroparalytic
All of the above
3d
multi
(All of the above) (106- Khurana 4th)ACANTHAMOEBA KERATITIS (Protozoal)1. Initial-lesions of acanthamoeba Keratitis are in the form of limbitis, coarse, opaque streakes fine epithelial and subepithelial opacities and radial -kerato- neuritis in the form of infiltrates along coreal nerves2. Advanced cases show a central...
Ophthalmology
Cornea
e9d1242f-edc9-4374-a856-14c743e6dbec
A 5-year-old girl begins developing secondary sexual characteristics, including pubic hair growth and breast development. Her concerned parents bring her to the pediatrician for evaluation. An abdominal ultrasound examination reveals an ovarian mass. The mass is resected and pathologic examination reveals it to be a gr...
Signet-ring cells
Call-Exner bodies
Schiller-Duval bodies
Transitional cell epithelium
1b
multi
A young patient presenting with precocious pubey and an ovarian mass is likely to have a granulosa cell tumor. Call-Exner bodies, small follicles filled with eosinophilic secretion, are an impoant diagnostic feature. Signet-ring cells are seen in Krukenberg tumors (bilateral metastatic involvement of the ovaries by a s...
Pathology
Ovaries & prostate gland
08fb0113-f430-4445-84a9-ef0072bfa834
LH peak occurs how many hours before ovulation ?
36-48 hrs.
12-24 hrs.
48-72 hrs.
72-96 hrs.
0a
single
Ans.B.)12-24 hours Ovulation occurs 34 to 36 hours after the onset of the LH surge and about 10 to 12 hours after the LH peak.
Physiology
null
92b70865-b201-4d25-972f-ef3079cb038a
Which one of the following is not a special incidence rate-
Attack rate
Secondary attack rate
Hospital admission rate
Standardized moality rate
3d
single
Ans. is 'd' i.e., Standardized moality rate Special incidence rates i) Attack rate (case rate) ii) Secondary attack rate iii) Hospital admission rate
Social & Preventive Medicine
null
4f1d8f4f-d7d0-4a8c-b16a-b6b489a40362
In case control study, the risk is calculated by?
Relative risk
Attributable risk
Cross product ratio
None
2c
multi
Ans. is 'c' i.e., Cross product ratio o Risk in case control study is calculated by odds ratio (cross product ratio).
Social & Preventive Medicine
null
b7cc4806-cb5d-4a00-a4ca-75b265265fe0
Rotterdam criteria are used to evaluate -
CA Breast
Aberrations in normal development and involution
PCOS
CA Cervix
2c
single
Answer- C. PCOSRotterdam criteriaTwo of the following three criteria are required :Oligo/anovulationHyperandrogenismClinical (hirsutism or less commonly male pattern alopecia) orBiochemical (raised FAI or free testosterone)Polycystic ovaries on ultrasound
Surgery
null
69c370f5-6e42-4b44-80ab-6376b3e03591
Ototoxic drugs are all except
Kanamycin
Streptomycin
Gentamicin
Ampicillin
3d
multi
Ampicillin is penicillin. Remaining 3 are aminoglycoside. Aminoglycosides are ototoxic.Other adverse effects of aminoglycosides are nephrotoxicity and NMB.ototocicity can be of auditory and vestibular most vestibulotocxic is sterptomycin followed by gentamycin and most auditory toxic is neomycin followed by amikacin Re...
Pharmacology
Other topics and Adverse effects
e3f23718-cc7c-4369-be21-2e85ecc4ea1c
Not a feature of diabetes mellitus in pregnancy
Postdatism
Hydramnios
Neonatal hyperglycemia
congenital defect
2c
single
Neonatal complications Respiratory distress syndrome Hypoglycemia Polycythemia Hyperbilirubinemia Hyperviscosity Cardiomyopathy Bih trauma Reference: Textbook of Obstetrics; Sheila Balakrishnan, 2nd edition; Page no: 241
Gynaecology & Obstetrics
Medical, surgical and gynaecological illness complicating pregnancy
93638f2d-6b25-4fe9-8cd1-39fe7f952d3c
A19 year old boy suffering from chronic schizophrenia is put on haloperidol in the dose of 20 mg/day. A week after the initiation of medication the patient shows restlessness, fidgety, irritability and cannot sit still at one place. The most appropriate treatment strategy is -
Increase in the dose of haloperidol
Addition of anticholinergic drug
Addtion of beta blocker
Adding another antipsychotic drug
2c
single
Ans: C Akathasia is the complication. It's the most common extrapyramidal side effect to develop due to use of antipsychotics. it appears within hoursto weeks of starting anti psychotics. Doc is propranolol.
Psychiatry
Pharmacotherapy Management of Children and Adolescents
7f0eec99-88fd-47d3-b64e-bca0955c5bef
Evidence based therapy of Bell's palsy include(s):
Facial nerve massage
Facial nerve stimulation
Steroid
Acyclovir
2c
single
Answer- C. Steroid1. Medical treatmentPrednisolone (steroid) is the drug of choice and is staed at initial visit. Initiation of therapy during first 24 hours of symptom confers a higher likelihood of recovery.Antiviral therapy (Acyclovir) is a newer adjunct in treating acute facial palsy of viral origin (both Bell's pa...
ENT
null
e4e4ee27-43e5-4bf5-bced-77043682864d
Which of the following is not a feature of Minimal change disease?
Hypertension
Edema
Proteinuria
Responsive to steroid therapy
0a
single
Ans. is 'a' i.e., Hypertension Minimal change disease (lipoid nephrosis)* Minimal Change Disease is the most common cause of Nephrotic syndrome in children.* Edema and Selective proteinuria are features of nephrotic syndrome. Fever may be present on account of increased susceptibility to infection.* Minimal change dise...
Pediatrics
Kidney
235e6a38-6976-49ff-acfb-11d819f94641
All are deep nuclei of cerebellum except-
Dentate nuclei
Emboliform nuclei
Fastigial nuclei
Caudate nuclei
3d
multi
Ans. is 'd' i.e., Caudate nuclei Important facts about cerebellumo Cerebellum is divided into -i) Cerebellar Cortex (external):- Contains five cellspurkinje cells, granule cells, basket cells, stellate cells and golgi cells.ii) Deep cerebellar nuclei (external):- There are four nuclei dentate fastigial, globose, and em...
Physiology
Cerebellum and Brainstem
3e31fc5e-7e0d-455a-a81c-cd09d5c47289
All are true about Entamoeba Histolytica except -a) Cyst are 8 nucleatedb) Cyst are 4 nucleatedc) Trophozoites colonise in the colond) The chromatid bodies are stained by Iodides
b
c
ac
ad
3d
multi
Cyst of E. histolytical is quadrinucleate (4 nuclei) Chromatid bodies do not stain with iodine but are seen as refractile oblong bars with rounded ends in preprations with normal saline and as black when stained with iron-haematoxylin. Trophozoites colonize cecum and ascending colon, sigmoid colon, rectum and appendi...
Microbiology
null
b44f58c6-778a-4151-8428-861173f20e6b
True about lupus vulgaris – a) Apple jelly nodule at root of noseb) TB of skin & mucosac) Also known as scrofulodermad) ATT is helpful
abd
bcd
abc
ab
0a
multi
Lupus vulgaris is the most common form of cutaneous (skin and mucosa) tuberculosis. Blanching with glass slide reveals grey green foci → Apple jelly nodules. Treatment is anti-tubercular drugs.
Dental
null
30c19d4b-e9df-4e14-8042-20cde472edb9
The intrinsic factor of the castle is secreted by which of the following cells in gastric glands
Chief cells
Parietal cells
Enterochromaffin cells
B cells
1b
single
Secretions of stomach -        HCl- Parietal cells/ Oxyntic cells -        The intrinsic factor of Castle- Parietal cells/ Oxyntic cells -        Pepsinogen- Chief cells/ Peptic cells -        Gastrin- G cells -        Somatostatin- D cells -        Histamine- ECL cells
Physiology
null
392035ee-0139-4c6e-adea-e4497e6a152f
Which anaesthetic is contraindicated in renal failure?
Isoflurane
Desflurane
Halothane
Methoxyflurne
3d
single
Ans. is 'd' i.e., Methoxyflurne Methoxyflurane It was most potent inhalation agent (least MAC), but not used not (now Halothane is most potent). o It should not be used in closed circuit (reacts with rubber tubing of the losed circuit). It has slowest onset & recovery (however now ether has slowest onset & recovery as ...
Anaesthesia
null
e1170155-2078-4c41-b9f7-2d4a5e9f1459
The aerial blood supply to the palatine tonsil is derived from branches of the external carotid aery. The principal aery is the tonsillar aery, which is a branch of the?
Facial aery
Lingual aery
Superficial temporal aery
Maxillary aery
0a
single
Facial Aery
Anatomy
null
942ebce9-a916-40e8-80f4-23b342b55b07
Which of the following is true of body iron stores?
Absorption is increased in iron deficiency and reduced in iron overload
Normally iron is stored as hemosiderin
Hepcidin increases iron absorption in iron overload
Transferrin is used as a storage form in iron overload
0a
multi
IRON DEFICIENCY ANAEMIA Iron Metabolism The amount of iron obtained from the diet should replace the losses from the skin, bowel and genitourinary tract. These losses together are about 1 mg daily in an adult male or in a non-menstruating female, while in a menstruating woman there is an additional iron loss of 0.5-1 m...
Pathology
miscellaneous
4c5512af-79f6-4aae-ab4c-a59134c9926f
Anaesthetic of choice in asthma patients: March 2007
Halothane
Thipentone
Ketamine
Feanyl
2c
single
Ans. C: Ketamine Ketamine is classified as an NMDA (N-methyl-D-aspaate) receptor antagonist, and at high, fully anesthetic level doses, ketamine has also been found to bind to opioid (mu) receptors and sigma receptors. Like other drugs of this class such as tiletamine and phencyclidine (PCP), it induces a state referre...
Anaesthesia
null
bcff1006-1f49-4150-84f5-cc8eb13844db
Arsenic poisoning presents with symptoms mimicking
Cholera
Dhatura poisoning
Barbiturates poisoniong
Morphine poisoning
0a
single
ARSENIC * Copper arsenite - sheele&;s green * Copper acetoarsenite - paris green * Permissible limits of arsenic in ground water - 0.05mg/L * The gastroenteric type of poisoning resembles cholera * Greatest quantity is seen in - liver * Red velvety appearance of mucosa of stomach * Most affected pa of the stomach - pyl...
Forensic Medicine
All India exam
437f9dcd-332f-4bd1-bc1c-ae04c912c247
After rupture of tympanic membrane the hearing loss is -
10-40 dB
5-15 dB
20 dB
300 dB
0a
single
null
ENT
null
c291cb0b-7ee2-45e8-8e0e-fff884882c71
Regarding diagnostic tests for syphilis, true is all except
VDRL test is used for measurement of antibody titers to assess response to treatment.
FTA-ABS is used to confirm diagnosis in clinically suspected syphilis.
TP-PA test is appropriate for population screening for syphilis.
Fourfold decrease in titer is required by 6 months after therapy for primary syphilis.
2c
multi
For population screening for syphilis, VDRL or RPR test is appropriate.
Gynaecology & Obstetrics
null
b33ee74b-ac01-4a85-bfcf-35d373786287
Psoralane Ultra Violet A (PUVA) therapy is advised in
Pemphigus vulgaris
Apthous ulcers
Carcinoma in situ
ANUG
0a
single
According to Rook and Colleagues the extra corporeal photochernotherapy for drug resistant pemphigus vulgaris include administration of 8-methoxypsoralen followed by exposure of peripheral blood to ultraviolet radiation. It is also used for vitiligo and graft versus host disease.
Pathology
null
ab76263d-6370-40df-9edb-dd57f42b313b
A 5-year-old girl presents with difficulty breathing. On examination, of the oral cavity a 3 cm mass is found in the midline on the posterior aspect of the tongue. The most likely diagnosis is:
Lingual tonsil
Lingual thyroid
Foreign body stuck to the tongue
Dermoid
1b
single
An ectopic thyroid gland can be located anywhere from the base of the tongue to the mediastinum. It often results in the failure of descent resulting in either a linginal thyroid or ectopic thyroid in the midline of the neck. The so called lateral aberrant thyroid is usually a metastasis from papillary carcinoma of the...
Surgery
Neck
d373bebf-6c5e-49a2-a51b-451358b47aaa
In those mammals which are seasonal breeder, the females are receptive only once in a year ; the cycle is termed as :
Follicular
Estrous
Menstrual
Luteal
1b
single
Ans. is b i.e. Estrous Estrous : It is cyclical period of sexual activity in non human female mammals, marked by congestion of and secretion by the uterine mucosa, proliferation of vaginal epithelium, swelling of the vulva, ovulation, and acceptance of the male by the female. During estrus, the animal is said to be "in...
Gynaecology & Obstetrics
null
bf734184-9689-495b-bcab-05bc108f0052
Acetazolamide can be used in all except :
Epilepsy
Acute mountain sickness
Cirrhosis
Glaucoma
2c
multi
null
Pharmacology
null
86df4d68-b1c6-4cc5-8bd1-f4c5fee14654
Joint between epiphysis and diaphysis of a long bone is a type of:
Plane Synovial joint
Fibrous joint
Symphysis
Synchondrosis
3d
single
Epiphysio-diaphyseal joint is a primary cartilaginous joint – synchondrosis. It is found in the growing bone, where the growth plate (hyaline cartilage) connects the epiphysis with the diaphysis, creating a hyaline cartilaginous joint. At this site the fate of synchondrosis is synostosis (bony fusion) after the growth ...
Anatomy
null
e3e9a2e5-d425-4c25-8cbe-6edcb34a76de
Main inspiratory muscle is -
Lattissimus dorsi
Transversus thoracis
Serratus anterior
Diaphragm
3d
single
Ans. is 'd' i.e., Diaphragm Respiratory musclesInspiratory muscles1. During quiet breathing : Diaphragm (most important), external intercostal and interchondral part of internal intercostal.2. During forced inspiration : Sternocleidomastoid, serratus anterior, serratus posterior superior, pectoral is major and minor, e...
Anatomy
Thorax
2a9c966b-2541-40a2-b92f-45b71d44fd8f
All are true about bulimia nervosa, except
Binge eating
Self-induced vomiting
Weight loss
Purgative abuse
2c
multi
Bulimia NervosaBulimia nervosa is an eating disorder characterised by the following clinical features:1. Bulimia nervosa usually has an onset in early teens or adolescence.2. There is an intense fear of becoming obese. There may be an earlier history of anorexia nervosa.3. There is usually body-image disturbance and th...
Psychiatry
Sleep disorders and eating disorders
c59d6475-a716-4905-b995-cd79efd7db0d
Kim et al classification system deals with:
Apical constriction
Apical foramen
Isthmus
No. of canals
2c
single
According to Kim et al Classification; there are 5 types Type I incomplete isthmus between 2 canals. Type II well defined, complete isthmus between 2 canals. Type III very short but complete isthmus between 2 canals. Type IV 3 or more canals with the complete or incomplete isthmus. Type V 3 or more canals without any ...
Dental
null
7b94a82b-2050-4007-92e4-f11a5b345a8a
A child presents with recurrent bouts of severe cough followed by an audible whoop. Which of the following is considered the best type of specimen to isolate the organism and confirm the diagnosis
Nasopharyngeal swab
Cough plate
Throat Swabs
Anterior Nasal Swab
0a
single
Peussis is an acute highly contagious respiratory tract infection caused by Bordetella peussis. Extremely contagious and clinical presentation can be divided into 3 stages like catarrhal, paroxysmal and convalescent It is called whooping cough due to the characteristic whoop produced by the air rushing in during inspir...
Pediatrics
Infectious disease
8f87627b-4847-4932-82cf-287be2550116
Ion exchange chromatography is based on -
Size
Charge
Solubility
Polarity
1b
single
Ans. is 'b' i.e.. Charge Property of protein usedMethodProtein solubility'Salting out' or salt extraction (precipitation of protein by ammonium sulfate)Molecular sizeo Gel filtration chromatography (molecular-sieve chromatography or size exclusion chromatography)o Ultracentrifugationo SDS-PAGE (Sodium dodecvl sulphate-...
Biochemistry
Miscellaneous (Structure & Function of Proteins)
63551d23-9a50-4e37-8e62-85f99e3d4afd
All of the following are useful in the management of acute asthma except :
Hydrocortisone intravenously
Salbutamol inhalation
Salmeterol inhalation
Terbutaline inhalation
2c
multi
null
Pharmacology
null
1fe3ced3-7f19-4382-a515-a185f9f46027
All of the following GIT hormones belong to secretin family except
Secretin
Glucagon
CCK
VIP
2c
multi
Cholecystokinin (CCK) is secreted by cells in the mucosa of the upper small intestine. It has a plethora of actions in the gastrointestinal system, but the most impoant appears to be the stimulation of pancreatic enzyme secretion, the contraction of the gallbladder (the action for which it was named), and relaxation of...
Physiology
G.I.T
acb85a85-b0f8-4170-864e-7f0235bf1b93
All are hepatotoxic drugs Except :
Erythromycin estolate
Rifampicin
Tetracycline
None
3d
multi
null
Pharmacology
null
fc8185de-7fe6-48a1-b7ba-436275aad437
Earliest sensation to be lost Hansens disease is -
Pain
Touch
Vibration
Temperature
1b
single
In Hansen&;s disease ,the earliest sensation to be affected is usually light touch. Reference; Park&;s Textbook of preventive and social medicine, 24th edition.Pg no. 332
Social & Preventive Medicine
Communicable diseases
7b85ca57-6236-430b-915c-2955e089b6bb
Most common site of intracranial hemorrhage in hepeensive hemorrhage is :
Basal ganglia
Brain.stem
Cerebellum
Hippocampus
0a
single
Basal ganglia The most common sites of hypeensive haemorrhage are: The basal ganglia (putamen, thalamus and adjacent deep white matter) Deep cerebellum Pons
Surgery
null
e032877f-7224-4383-85ed-876bf7a86e1c
Which mutation is seen in Down’s syndrome -
Monosomy X
Trisomy 21
Trisomy 22
Trisomy 22
1b
single
The basic molecular defect in Down's syndrome is the extra genetic material of chromosome 21. It may be due to : 1) Trisomy 21 This is the most common cause (95%). There is an extra chromosome 21 (i.e. three 21 chromosomes) which is due to meiotic nondisjunction in the ovum. The extra chromosome is of maternal origin...
Pediatrics
null
d0e0f926-3c6c-4f9c-89bb-d86c48483b93
Testicualr tumor with best prognosis is :
Teratoma
Seminoma
Choriocarcinoma
All of the above
1b
multi
null
Surgery
null
fe9ab9d9-733f-46d6-981b-546b1058dac2
Trochanteric fracture of the femur is best treated by -
Dynamic hip screw
Inlay plates
Plaster in abduction
Plaster in abduction and internal rotation
0a
single
Dynamic hip screw (DHS) plate is the implant of choice for fixation. These days proximal femoral nail (PFN) is also commonly used.
Orthopaedics
null
c151b56a-5a12-4136-8a6a-9e938be7bf5d
Destructive power of bullet is determined by all except
Velocity of bullet
Weight of bullet
Shape of bullet
Kinetic energy
2c
multi
Ans. is 'c' i.e., Shape of bullet * Tissue damage (or destructive power of bullet) is dependent on striking (kinetic) energy of bullet, which is proportional to its mass and square of velocity (KE = Vi mv2). So modern bullets are designed to have smaller mass allowing transportation of large amount of ammunition and hi...
Forensic Medicine
Injuries
20a1b1e7-6e92-420d-8ac5-ff6ba176295a
Essential amino acid is:
Phenylalanine
Proline
Glutamine
Serine
0a
single
Phenylalanine It is an alpha-amino acid. This essential amino acid is classified as nonpolar because of the hydrophobic nature of the benzyl side chain. L-Phenylalanine (LPA) is an electrically neutral amino acid The codons for L-phenylalanine are UUU and UUC. Phenylalanine is a precursor for tyrosine, the monoamine si...
Biochemistry
null
b6f2d72c-3f76-446f-92c5-87fae48a677d
Savlon contains :
Cetrimide and cetavlon
Cetrimide and Chlorhexidine
Cetrimide, Chlorhexidine and butyl alcohol
Cetrimide and butyl alcohol
1b
single
Savlon is a very popular disinfectant in the hospitals and it contains chlorhexidine and cetrimide.
Pharmacology
null
21fa1168-73bb-4515-b6d8-798b7ecdd899
Which of the following condition is associated with a loss of attenuation reflex?
Stapedial palsy
Glomus tumor
Internal ear pathology
Malingerers
0a
single
In stapedial palsy, damage to the nerve result in a reduction in sound attenuation reflex resulting in sound being heard excessively loud in the affected ear (hyperacusis). Attenuation reflex: When very loud sound is transmitted through the ossicular system to CNS a reflex is initiated with a latent period of 40 to 80m...
ENT
null
2a644837-f62b-4860-8082-96cf6f9b4f8a
In a patient with chronic atrial fibrillation with a regular beat of 60/min, the most probable cause is-
Sleep
Digitalis toxicity
Sino nodal block
Hypothyroidism
1b
single
The health care provider may hear a fast heabeat while listening to your hea with a stethoscope. Your pulse may feel fast, uneven, or both. The normal hea rate is 60 to 100 beats per minute. In atrial fibrillation or flutter, the hea rate may be 100 to 175 beats per minute Digoxin toxicity is a life-threatening conditi...
Medicine
C.V.S
96287d02-8aa5-4b92-98ea-2eefe0ceb0f4
2nd constriction of esophagus is due to -
Left principal bronchus
Arch of arorta
Pharyngoesophageal junction
None
1b
multi
Ans. is 'b' i.e., Arch of arorta Esophageal constrictionsNumberDistance from incisorBony levelAnatomical landmark1st2nd3rd4th15 cm (6 inches)22-5 cm (9 inches)27-5 cm (11 inches)37 -5 -40 cm (15-16 inches)C6T4T6T10At its beginning (pharyngoesophageal junction)Crossing of aortic archCrossing of left main bronchusPiercin...
Anatomy
Thoracic Duct & Esophagus
7f23b0ed-dd25-4d64-a1ad-b1b5883363b0
A person identifies a pattern on wall as an animal is having:
Hallucination
Delusion
Illusion
Sensory distortion
2c
multi
Ans: c) IllusionIllusion:Misinterpretation of stimuli arising from an external object. There are three types:i) Complete illusion: depends on inattention of the person. For eg: misreading words in newspapers / missing misprints, we read the word automatically as if it were complete. It also depends on our previous expe...
Psychiatry
Symptoms & Signs
263a179f-1720-4174-82e6-398df4c1ba8a
True about caput succedaneum is -
Crosses the suture lines
Always present at birth
Resolves in 24-48 hours
All of the above
3d
multi
Ans. is 'd' i.e., All of the above * A caput succedaneum is an edema of the scalp at the neonate's presenting part of the head. It often appears over the vertex of the newborn's head as a result of pressure against the mother's cervix during labor. The edema in caput succedaneum crosses the suture lines 8c its always p...
Gynaecology & Obstetrics
Miscellaneous (Gynae)
28167b41-88dc-4acd-a31b-57054cc64c24
What is the uppermost intercostals space used for hepatic biopsy -
7th
10th
5th
9th
0a
single
Proper identification of the biopsy site is of paramount impoance. To choose the site, sta with percussion over the right upper quadrant. The biopsy site is usually located in the seventh or eighth intercostal space in the midaxillary line. The site can be fuher confirmed with either routine ultrasonography or a bedsid...
Medicine
G.I.T
2d6650ab-82fe-46e0-9db3-4ee00a6b3ad5
Anti-inflammatory drug that can safely be used in children is
Paracetamol
Ibuprofen
Diclofenac
Nimesulide
1b
single
Ans. b (Ibuprofen). (Ref. KDT 6th/pg. 191)AnalgesicPropertiesNimesulideDue to gastrointestinal, dermatological, renal & fulminant hepatic failure side effects, its safety, especially in children is questional. Banned in USA.IbuprofenSafest conventional NSAID.But should not be prescribed to pregnant women & peptic ulcer...
Pharmacology
Miscellaneous (Pharmacology)
55a4e602-2837-48e3-bc02-11540ff9d155
Keloid scars:
Usually occur in the Caucasian race
Often occur in wounds which have healed perfectly without complications
Surgical treatment as a single modality has the least recurrence
Radiation should not be administered as it is a non¬malignant condition
1b
multi
null
Surgery
null
983ccd7a-b123-4442-abbb-c95ef7499a72
Exclusive breastfeeding is advised till what age?
3 months
6 months
9 months
10 months
1b
single
Exclusive breastfeeding advised for 4-6months of age.(Refer: OP Ghai's Textbook of Pediatrics, 8th edition, pg no. 60, 122)
Pediatrics
All India exam
a72e5417-a383-436e-b652-f504052c925c
Which is true about Burkitt's lymphoma?
CD34 +ve & surface Immunoglobulin +ve
CD34 +ve & surface Immunoglobulin -ve
CD34 -ve & surface Immunoglobulin -ve
CD34 -ve & surface Immunoglobulin +ve
3d
multi
Forms of Burkitt lymphoma: Sporadic and endemic Sporadic type: Presents in the abdomen near the ileocecal valve, in the ovaries, or in the retroperitoneum; 15-20% of sporadic-type Burkitt lymphomas are associated with EBV infection. Endemic type: Commonly presents in the jaw. All endemic-type Burkitt lymphomas are asso...
Pathology
null
2ae300c9-e1d2-4827-98a5-44c8b8a6f0d6
The characteristic of the pulmonary circulation:
High resistance, high compliance
Low resistance, low compliance
High resistance, low compliance
Low resistance, high compliance
3d
single
Pulmonary aery pressures are reflective of RV pressures .Pulmonary circulation is low pressure, low resistance circulation as compared to systemic circulation. Pulmonary vessels are about 24 times more compliant compared to their systemic counterpas. Pulmonary circulation, in a sho route, has to accommodate large quant...
Physiology
Respiratory System
69ccc4e3-9e53-45e6-9c64-a8071be4a348
Roopa Devi, a 65-year-old female with lymph-node-positive breast cancer was treated with systemic chemotherapy. Four weeks later, she developed frequent urination, suprapubic pain, dysuria, and hematuria. Which of the following could have prevented this patient's condition?
Folinic acid
Mesns
Dexrazoxane
Amifostine
1b
single
(Ref: Katzung 11/e p942) The patient described in the question has henorrhagic cystitiws caus3d by drugs like cyclophosphamide and ifosfamide. Hemorrhagic cystitis during therapy with cyclophosphamide or ifosfamide is caused by the urinary excretion of the toxic metabolite acrolein. This can be preventede by aggressive...
Pharmacology
Other topics and Adverse effects
fd7a96fe-1436-4ebd-a66f-d6524a81dc95
A patient made a self-diagnosis of athlete's foot (tinea pedis) and began using a product adveised on television. The condition improved but did not clear and then the patient showed himself to a Dermatologist. A skin scraping was sent to the laboratory for culture, including culture for fungi. The fungal culture yield...
Trichophyton
Microsporum
Epidermophyton
Trichosporon
1b
multi
Ans. is 'a' i.e., Trichophyton . Dermatophytes can be identified by their colonial appearance and microscopic morphology after growth for 2 weeks at 25degc on sabouraud's dextrose agar. . Differential diagnosis of Dermatophytes on the basis of Macroconidia and microconidia General Microconidia Macroconidia Trichophyton...
Microbiology
null
ab4aecea-2371-41f6-9413-08b83e0a4783
Cerebral amaebiasis is not caused by:
Naegleria
Dientamoeba
Acanthamoeba
Balamuthia
2c
single
Ans. c. Dientamoeba
Microbiology
null
e084cba4-4467-4a69-8e7e-1fd25e43b770
Sensory nerve supply of middle ear cavity is provided by:
Facial
Glossopharyngeal
Vagus
Trigeminal
1b
single
(b) Glossopharyngeal(Ref. Scott Brown, 8th ed., Vol 2 page 535)The sensory supply of the middle ear is by the tympanic plexus which is formed by the Jacobson's nerve which is the tympanic branch of Glossopharyngeal (IX) along with sympathetic plexus from around the internal carotid.
ENT
Ear
4125d594-0304-4a75-903f-d5a5dbaec5ec
All are features seen in Chronic Pancreatitis except ?
Chronic persistent pain
Diarrhoea, Steatorrhoea
Calcification
Paralytic ileus
3d
multi
Ans. is 'd' i.e., Paralytic ileus
Surgery
null
0250b33f-a4fb-425f-999e-42512a759377
Best indication foe testicular biopsy in male is:
Polyspermia
Oligospermia
Necrospermia
Azoospermia
3d
single
Testicular Biopsy in Male Infeility The testis biopsy provides direct information regarding the state of spermatogenesis Abnomalities of seminiferous tubules architecture and cellular composition are then categorized into several patterns. This procedure is most useful in the azoospermia patient, in which it is often d...
Surgery
Urology
e4f0738f-a824-430d-aaca-02577ddb637c
All of the following are sexually transmitted, Except –
Candida albicans
Echinococcus
Molluscum contagiosum
Group B streptococcus
1b
multi
Echinococcus granulosus (Hydatid disease) is not a STD. All other three options are STDs.
Dental
null
9c86c6a5-8846-4990-a296-1e840bfe000f
A 78-year-old man with a history of coronary aery disease and an asymptomatic reducible inguinal hernia requests an elective hernia repair. Which of the following would be a valid reason for delaying the proposed surgery?
Coronary aery bypass surgery 3 months earlier
A history of cigarette smoking
Jugular venous distension
Hypeension
2c
single
The work of Goldman and others has served to identify risk factors for perioperative myocardial infarction. The highest likelihood is associated with recent myocardial infarction: the more recent the event, the higher the risk up to 6 months. It should be noted, however, that the risk never returns to normal. A non-Q-w...
Anaesthesia
Preoperative assessment and monitoring in anaesthesia
5fd74d5f-3d32-4823-ac9f-556e5be1ba8d
Among the following, which one is not good dietary source of iron -
Liver
Jaggery
Fish
Milk
3d
single
Haem iron is present in liver, meat, poultry, and fish. Non haem iron is present in green leafy vegetable,jaggery and dry fruit. REF. PARK'S TEXTBOOK OF PREVENTIVE AND SOCIAL MEDICAL 21ST EDITION. PAGE NO - 623
Social & Preventive Medicine
Nutrition and health
daa7340b-639c-4ad5-a66a-79d593d641a2
The fold in collagen is because of presence of:
Histidine
Glycine
Argininc
Glutamate
1b
single
The fold in collagen is because of presence of Glycine. ADDITIONAL READING ON STRUCTURE OF COLLAGEN: Collagen is made up of 3 alpha- chains (not alpha helix). These 3 chains together make a superhelix --> Tropocollagen(a rope like triple helix) Superhelix (right handed) is oured by Glycine residues. Glycine has the sma...
Biochemistry
Glycine Metabolism Detail
253a14cc-8ca3-44c0-97f3-0006d820939a
The unique propey of SERMs is that they:
Have both estrogenic and progestational agonistic activity
Inhibits the aromatase enzyme that is required for estrogen synthesis
Produces estrogenic effect without binding to estrogen receptors
Act as agonist in some tissues and antagonist in other tissues
3d
multi
SERM: 1. Raloxifene- Agonist at bone - Agonist in blood : Increase HDL level- Antagonist at breast: Decrease breast carcinoma risk- Antagonist at endometrium: Decrease endometrium carcinoma- Agonist at liver: Increase thromboembolism risk 2. Tamoxifen- Agonist at bone - Agonist in blood : Increase HDL level- Antagonist...
Pharmacology
Osteoporosis, Sex Hormones and OCPs
a25051b0-38e2-489b-973f-68488093d961
The common organism isolated in Emphysematous pyeloneohritis is
E. Coli
Proteus
Pseudomonas
Klebsiella
0a
single
Emphysematous pyelonephritis (EPN) is a severe, necrotizing infection of the renal parenchyma causing gas formation within the collecting system, renal parenchyma, and/or perirenal tissues. Also called renal emphysema and pneumonephritis. Gas in the renal pelvis alone, without parenchymal gas, is often referred to as e...
Surgery
Urology
49a16e93-7129-4023-9356-c09c0831118f
A patient presents with a platelet count of 700 x 109/L with abnormalities in size, shape and granularity of platelets. WBC count of 12 x 109 /L, hemoglobin of 11g/dl and the absence of the Philadelphia chromosome. The most likely diagnosis would be-
Polycythemia vera
Essential thrombocythemia
Chronic myeloid leukemia
Leukemoid reaction
1b
single
null
Pathology
null
be4e39a8-9497-4e46-a7e9-56d5eff39800
Which of the following is the most commonly used site for Transcranial Magnetic Stimulation to reduce frequency of Parkinsonism symptoms:
Striatus
Globus Pallidus
Subthalamic Nucleus
Putamen
2c
multi
Answer is C (Subthalamic Nucleus): Primary Targets Subthalamic Nucleus (STN) Globus Pallidus Internus (GPI) Subthalamic Nucleus (STN) is the single most common preferred site for Deep Brain Stimulation in patients with Parkinsonism. Globus Pallidus Internus (GPi) is the second most common site for Deep Brain Stimulatio...
Medicine
null
03269bf3-37ef-432a-96f8-9a4f510af8de
Renal plasma flow is increased by 50-75% during pregnancy. Which of the following is normally seen in the urine of a pregnant woman in the third trimester?
Glucose
Galactose
Fructose
Sucrose
0a
multi
During pregnancy, renal threshold is diminished due to the combined effect of increased glomerular filtration and impaired tubular reabsorption of glucose. Also know: During pregnancy, renal tubules also fail to reabsorb uric acid, amino acids, water soluble vitamins and other substances completely. Glycosuria on one o...
Gynaecology & Obstetrics
null
ab75d591-7c8c-48c8-b7f8-2207c230e5d6
Post transcriptional modification include all except:
5' capping
3' polyadenylation
Splicing
Glycosylation
3d
multi
Glycosylation is a post translational modification, not a post transcriptional modification. Post Translational Modifications Post Transcriptional Modifications Phosphorylation Capping at 5'end Glycosylation (most frequent) Removal of Introns/ Splicing Hydroxylation Tailing at 3'end Acetylation Vit K Dependent Carboxyl...
Biochemistry
Transcription
b2141e6c-2386-4906-b069-c5fe6fbfd5a6
Kaposi sarcoma is seen in -
Leukemia
Lymphoma
AIDS
Cytomegalovirus infections
2c
single
null
Surgery
null
4b439229-a9ed-481f-9889-5e5715e8a707
Oxalate crytals in urine is seen in -
Ethylene glycol poison
Di glycol poison
Alcohol
Indivavir
0a
single
Oxalate crystals in urine is seen with Ethylene Glycol poisoning. Renal pain and acute tubular necrosis in it, occurs due to renal calcium oxalate precipitation. Other features includes, opthalmoplegia, cranial nerve palsies, hyporeflexia and myoclonus Reference: Harrison20th edition pg pg 789
Medicine
Toxicology
355df8ca-ea7e-4834-b7fc-6372c73a7830
An HIV positive patient is pregnant. During which of the following stage is HIV transmission maximum?
Labour
Early pregnancy
Late pregnancy
Post delivery
0a
single
Majority of HIV transmission occur during labour (40-80%). Perinatal transmission of HIV: Veical transmission of HIV to the neonate is about 14 - 25%. Transmission of HIV 2 is less frequent (1-4%) than HIV 1(14-35%). Veical transmission of HIV is more in cases with preterm bih and with prolonged membrane rupture. Risk ...
Gynaecology & Obstetrics
null
a65d5def-6a8f-4ef6-aab2-9654b9dacefe
Porin present in-
Cell wall of gram positive bacteria
Cell membrane of gram positive bacteria
Cell wall of gram negative bacteria
Outer membrane of gram negative bacteria
3d
multi
Ans. is 'd' i.e.. Outer membrane of gram negative bacteria o Cell envelop of bacteria comprises-An outer membrane (only in gram negative bacteria).A cell wall composed of peptidoglycan.Periplasm (only in gram negative bacteria).Cell membrane (cytoplasmic membrane), wrhich encloses cytoplasm.o Outer membranes, which are...
Microbiology
General
fad29693-a438-4461-8ed8-a62ed18bc338
M in 99Tc"' stands for?
Micro
Mega
Metastable
Metastatic
2c
single
Metastable REF: Nuclear Physics: Principles And Applications by Lilley Page 20 "In 99Tcm the superscript M denotes that the technetium 99 is not in its ground state but a long lived metastable excited state"
Radiology
null
3db37ca6-c82d-4fd2-b0a5-6d7efcc659cc
In MI, which enzyme is raised in 4 to 6 hrs and decreases in 3 to 6 days -
SGOT
LDH
CPK
SGOT
2c
single
Ans. is 'c' i.e., CPKCreatinine phosphokinase (CK) Previously It was the gold standard marker of acute Ml.o But now it has largely been replaced by troponin T and I (see above explanation).o But, CK remains the best alternative to troponin measurement.CK-MB isotype of this enzyme is specific for myocardium.It is raised...
Pathology
null
a5c19009-dbf7-449d-9b85-939da7ccac97
Which of the following statements in not true regarding Lac Operon concept
CAP is a positive regulator of LAC operon
It is regulation method in eukaryotes and prokaryotes
It is inducible operon
Lac Z gene codes for β galactosidase.
1b
multi
Lac operon is regulatory method seen only in prokaryotes.
Biochemistry
null
baa471b1-7296-45c4-b051-43443803fc78
During treatment for Wilson disease with trientine and penicillamine, free serum copper should be kept below which level?
25 mcg/dl
50 mcg/dl
75 mcg/dl
100 mcg/dl
0a
single
The normal free copper value is 10-15 mcg/dL and it is often as high as 50 mcg/dL in untreated Wilson's disease. With treatment, free copper should be <25 mcg/dL. Reference: Harrisons Principles of Internal Medicine, 18th Edition, Page 3190
Medicine
null
1dcc7baa-98e2-4dc9-9dfb-d28aa95e03b6
Psammoma bodies shows which type of calcification -
Metastatic
Dystrophic
Secondary
Any of the above
1b
multi
Ans. is 'b' i.e., Dystrophic
Pathology
null
6b82db1a-9535-4442-9b79-dc90fa288524
The order of sensory blockade of local anesthesia is:
Temperature - pain - touch - pressure
Pain - pressure - touch - temperature
Touch - pressure - temperature - pain
Touch - pain - pressure - temperature
0a
single
Individual type of nerve differs in their minimal blocking concentration. Not all sensory and motor modalities are blocked equally by local anesthetics. This is termed differential blockade. For different fibers order of blockade b > AS = C > AU > A b > Aa autonomic > sensory> motor is the sequence of block. for sensor...
Anaesthesia
Regional Anesthesia