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135
c208136e-f01f-4dfd-9666-d6dfeadfd8c5
Ebstein anomaly is known teratogenic effect due to this drug:
Clozapine
Phenytoin
Lithium
Lamotrogine
2c
single
(Ref: Katzung, 14th ed. pg. 527)* Lithium is DOC in manic disorder.* DOC for prophylaxis of mania: Lithium* DOC for acute attack of mania: Sedative + Atypical antipsychotics* DOC for mania in pregnancy: Atypical antipsychotics* Side effect of lithium (Mn: LITTH)# L: LEUCOCYTOSIS# I: Insipidus diabetes# T: Tremors (MC s...
Pharmacology
C.N.S
90148cb8-a5f2-418f-8af5-be80853e7e50
Recent nobel prize for -
RNA i
Lipoxin
T beta transcription factor
Mitochondrial DNA
0a
single
null
Microbiology
null
583294f9-4cc8-4b74-b445-6d38cd1fdfc3
If a fibrinolytic drug is used for the treatment of acute myocardial infarction, the adverse effect most likely to occur is:
Acute renal failure
Development of antiplatelet antibodies
Encephalitis secondary to liver dysfunction
Hemorrhagic stroke
3d
single
Bleeding is the most common adverse effect of anticoagulants, antiplatelets and fibrinolytic agents. Bleeding can manifest as hemorrhagic stroke in pts. on fibrinolytics therapy such as- Alteplase, Retaplase, Streptokinase. C/I of Fibrinolytics :- H/O Hemorrhagic Stroke H/O NON Hemorrhagic Stroke (within 1yr) Suspicion...
Pharmacology
Hematology
bcffe1d6-16f0-4ceb-a7d8-efbd80de1c5d
Most impoant indicator of successful neonatal resuscitation:
Color change
Improved air entry
Increase in hea rate
Bilateral chest movements
2c
single
Most impoant indicator of successful neonatal resuscitation - Increase in hea rate.
Pediatrics
Neonatal Resuscitation
bb5756b8-129f-49a7-9565-db32001f9888
In an after coming head the following bone is perforated during decapitation:
Occiput
Parietal
Palate
Frontal
0a
single
null
Gynaecology & Obstetrics
null
346a8a7b-20f4-461a-aec8-726a9f87a187
Courvoiser's law exception
Double impaction
Poal lymphademopathy
Periampullary CA
None
0a
multi
Answer- A. Double impactionCourvoisier's law states that in the presence of an enlarged gall bladder which is nontender and accompanied with jaundice the cause is unlikely to be gallstones. This is because gall stones areformed over alonger period oftime, and this result in a shrunken, fibrotic gall bladder which does ...
Surgery
null
036bad02-0362-4fcd-8581-8303c9809768
Which drug is vassopressin V2 receptor selective agonist -
Lypressin
Desmopressin
Terlipressin
None
1b
multi
Ans. is 'b' i.e., Desmopressin o Lypressin - Agonist on V1 & V2.o Desmopressin - Selective V2 agonisto Terlipressin - Prodrug of vasopressin.
Pharmacology
Diuretic
31ae221e-4db7-4f18-9d3b-ad022cd94e8a
About Vi polysaccharide vacine, true is:
Can be given in patients with yellow fever and hepatitis B
Has many contraindications
Has many serious systemic side effects
Has many serious local side effects
0a
multi
Ans. is (a) Can be given in patients with yellow fever and hepatitis B Yellow fever is not a contraindication for VICPS typhoid vaccine.
Microbiology
null
3c79b800-6b90-4dd1-a3fc-dd62972b6c15
Dental lamina cysts of new born are seen at:
The junction of hard and soft palate
Along the median raphae of hard palate
The alveolar ridges
None of the above
2c
multi
"Bohn's nodules" are seen at the junction of hard and soft palate, whereas "Epstein pearls" are seen along the median raphae of hard palate. A third type known as "Dental lamina cysts of new born" are seen on the alveolar ridges.
Pathology
null
2d70c5df-0049-460b-88c0-c88a581e657e
Anaerobic bacteria commonly found in cervix or vagina?
Lactobacilli
Gardnerella
Mobilincus
Clostridium
0a
single
ANSWER: (A) LactobacilliREF: Shaw 13th ed p. 125"Lactobacillus or Doderlein's bacillus is the most common organism found in vagina"
Gynaecology & Obstetrics
Vigina
52844af1-36f9-4bcf-9996-b3342f6c0c55
Orally active hormone is:
TSH
Thyroxine
GH
Prolactin
1b
multi
null
Pharmacology
null
c5fb74f3-eb89-4d34-8198-313de0534645
A 26 yrs old male with restriction of eye movements in all directions &moderate ptosis but with no diplopia or squint. Diagnosis is
Thyroid ophthaltnopathy
Chronic progressive external ophthalmoplegia
Myasthenia gravis
Multiple cranial nerve palsies
1b
multi
Chronic progressive external ophthalmoplegia Bilateral ptosis without diplopia is seen in chronic progressive external ophthalmoplegia (CPEO). Ptosis & diplopia are presenting symptoms in approx 50% of patients of Myasthenia gravis, & subsequently develop in 96% of patient during the course of the disorder. In thyroid-...
Ophthalmology
null
a83ae59c-9f53-418b-a363-00fc556a9fe5
All are markers of Mantle cell lymphoma except -
CD5
CD 19
CD 20
CD 23
3d
multi
null
Pathology
null
93f78fc7-8ce8-421e-9918-c4efdee0f961
Convulsions in a child with dehydration and vomiting can only be due to-
Decreased serum sodium
Decreased serum magnesium
Decreased serum potassium
Decreased serum potassium
0a
single
Ans. is 'a' i.e., Decreased serum sodium
Pediatrics
null
b5483b81-c60b-4e23-a5f9-66a27556d2d1
Which among the following is highest risk factor for molar pregnancy
Prior C-section
Hypertension in pregnancy
Advanced age
Diabetes in pregnancy
2c
single
Strongest risk factors for molar pregnancy are age and prior history of molar pregnancy.
Gynaecology & Obstetrics
null
33fee40c-5c53-4b81-b1f2-e0041cd8a2cb
Which of the following is not a difference between Centric relation and Centric occlusion?
Centric relation is a bone to bone relationship. Centric occlusion is the relationship of upper and lower teeth to each other.
Centric relation is for denture occlusion, whereas centric occlusion is present in natural dentition.
For denture patients CR=CO. For natural dentition CR≠CO.
In natural dentition, the centric occlusion is usually posterior to centric relation
3d
multi
Centric relation is present behind centric occlusion in natural dentition.
Dental
null
5180b0b3-8c20-4b17-9d39-b5096f91e3d8
Optimal front-line treatment of squamous cell carcinoma of the anal canal includes:
Abdominal perineal resection.
Low anterior resection when technically feasible.
Radiation therapy.
Combined radiation and chemotherapy.
3d
multi
Combination radiation therapy and chemotherapy is now the treatment of choice for squamous cell carcinoma of the anus. The area of the primary lesion is biopsied, and the patient begins radiotherapy to the pelvis. If inguinal lymph nodes are enlarged, they are also biopsied, usually by fine needle aspiration, and if po...
Surgery
Rectum and anal canal
205aa6ee-1223-47f3-a1ff-7690eef22da4
NOT a feature of Holt Oram Syndrome is
Absent Radius
Atrial septal defect
Thrombocytopenia
Autosomal dominant inheritance
2c
single
Holt Oram Syndrome Patient have normal blood picture.
Pediatrics
null
802f0634-768b-41fa-8db0-a21036a0135c
Patient presents to casualty with sudden onset LMN facial palsy on right side and inability to abduct right eye. There is left sided hemiparesis. Whats your diagnosis?
Fovilles syndrome
Milard gubler syndrome
Ramsay hunt syndrome
Tolosa hunt syndrome
1b
single
Triad of ipsilateral 6th nerve palsy, ipsilateral 7th nerve palsy and contralateral hemiparesis constitutes milard gubler syndrome.
Anatomy
null
3695ce48-9b9c-4155-9877-2e7866a7bc88
Burst EEG pattern is seen in?
Herpes simplex encephalitis
Absent seizures
Myoclonic epilepsy
SSPE
1b
single
Burst suppression is an electroencephalography (EEG) pattern that is characterized by periods of high-voltage electrical activity alternating with periods of no activity in the brain. The pattern is found in patients with inactivated brain states, such as from general anesthesia, coma, or hypothermia EEG video monitori...
Medicine
C.V.S
c9d8d498-c53b-47a7-a74b-fbe649372d4b
The coronal pulp has
Two surfaces
Five surfaces
Six surfaces
Four surfaces
2c
single
null
Dental
null
e3fdfcda-450d-44fa-bbdf-244abb70e4c5
The most common site of osteoma is( REPEAT QUESTION)
Maxillary sinus
Ethmoidal sinus
Frontal sinus
Sphenoid sinus
2c
single
Most osteomas are asymptomatic and are found incidentally when imaging the sinuses either for sinonasal symptoms or for unrelated complaints. Osteomas are frequently seen elsewhere in the head and neck paicularly the mandible and outer table of the skull vault. There is a paicular frequency distribution within the para...
ENT
Nose and paranasal sinuses
a494bc66-0ed0-4340-8a17-a6434248e318
Investigation of choice in cholestasis of pregnancy ?
Serum bilirubin levels
Serum bile acids levels
Serum alkaline phosphatase levels
Serum glutathiones transferase levels
1b
single
Ans. is 'b' i.e., Serum bile acid levels Obstetric cholestasis (also known as intrahepatic cholestasis of pregnancy or cholestasis of pregnancy) is a liver disease unique to pregnancy which presents with pruritus.Clinical featuresObstetric cholestasis most commonly presents in the third trimester (80% develop symptoms ...
Gynaecology & Obstetrics
Hepatic, Biliary, and Pancreatic Disorders
780c5d75-8009-4c14-b9c0-d63c79a48abe
Half-life of basiliximab is:-
7 days
7 hours
15 days
24 hours
0a
single
Half life of basiliximab is 7 days.Basiliximab* This is anti CD-25 antibody with higher affinity for the IL-2 receptor, but shoer plasma t 1/2 (1 week).* It is used to prevent renal and other transplant rejection reaction.* It can cause anaphylactic reactions and promote oppounistic infection.
Pharmacology
JIPMER 2019
6336772f-0a4c-44d3-96d5-ecabbdac91f2
Poiseuille’s hagen lawis
F = (PA–PB) × 3.14 × r4/8nl
F = (PA+PB) × 3.14 × r4/8nl
F = (PA/PB) × 3.14 × r4/8nl
F = (PA × PB) × 3.14 × r4/8nl
0a
single
Poiseuille-Hagen Formula The relation between the flow in a long narrow tube, the viscosity of the fluid, and the radius of the tube is expressed mathematically in the Poiseuille-Hagen formula:
Unknown
null
55b33c8a-2a0d-497d-96d0-234641a7438c
A patient presented with a 3.5-cm size lymph node enlargement, which was hard and present in the submandibular region. Examination of the head and neck did not yield any lesion. Which of the following investigations should follow?
Chest X-ray
Triple endoscopy
Supravital oral mucosa staining
Laryngoscopy
1b
single
Suspected lymph node may have metastases from the upper aerodigestive tract. Since no lesion is found on physical examination of head and neck, triple endoscopy would be justified next. Supravital staining helps in selecting the site of biopsy in a lesion. As no lesion is discovered, it will not be very useful.
ENT
Oral Cavity
a7bf373a-3372-495d-a53e-c12a9142f8d6
Hour glass deformity is seen in -
Carcinoma stomach
Peptic ulcer
Duodenal atresia
CHPS
1b
single
Hour glass stomach is caused due to cicatracia contraction of a saddle shaped ulcer at the lesser curvature.
Pathology
null
9775593b-66b1-44a6-8c02-cba3e6e4eee1
Most common detion used in social medicine is-
Mean
Range
Variance
Standard detion
3d
single
Ans. is 'd' i.e., Standard detion "Standard detion is most common and generally most appropriate measure of dispersion (variation)".
Social & Preventive Medicine
null
f8a8f6c5-75bf-42f0-8e01-805144fba3a8
Which of the following is an investigation of choice to diagnose gall stones?
X ray abdomen
Ultrasound abdomen
ERCP
MRCP
1b
multi
Ans. B. Ultrasound abdomenCholelithiasis involves the presence of gallstones which are concretions that form in the biliary tract, usually in the gallbladder. Choledocholithiasis refers to the presence of one or more gallstones in the common bile duct (CBD) Patients with uncomplicated cholelithiasis or simple biliary c...
Pediatrics
Gastro Intestinal System
072290c4-b911-42df-852d-bc92f95f1c68
The Most common complication in varicose vein surgery is
Ecchymosis
Deep vein thrombosis
Recurrence of varicosity
Venous ulcer
0a
single
(A) Ecchymosis # Complications of varicose vein surgery: Bruising and discomfort are common following removal of varices, especially where the veins were of very large diameter. However, the pain usually requires only mild analgesics.
Surgery
Miscellaneous
e6becfc9-5431-4e30-8e64-b453a9e40d95
Females with orgasmic difficulties are advised following exercises to strengthen pubococcygealmuscles-
Kegel's exercises
Jacobson's stent on top
Keeping muscle up exercises
Johnsons exercises
0a
single
Ans. is 'a' i.e., Kegel's exercises o Kegels exercises are used to strengthen the pelvic floor muscles mainly pubococcygeal.o These exercises can thus be used to treat orgasmic difficulties and prevent genital prolapse.
Gynaecology & Obstetrics
Management
8007ba1f-1ff9-4c2a-b9b1-f21ffeda9732
A 3 year old male presents with a skin rash and epistaxis. He has had several, severe sinopulmonary infections. A careful history reveals that his maternal uncle died of bleeding complications following an emergency cholecystectomy. What additional findings are likely in this case?
A CD4/CD8 ratio of < 1.5:1
Cerebellar ataxia
Elevated platelet count and high serum IgG, IgA, and IgE levels
Low platelet count and low serum IgM levels
3d
single
This clinical scenario is typical for Wiskott-Aldrich syndrome. This is a sex-linked recessive disorder presenting with the triad of thrombocytopenia, eczema, and recurrent sinopulmonary infections. Serum IgM levels are low but IgG, IgA, and IgE levels are increased. Patients have a defective response to polysaccharide...
Medicine
null
a9fed167-929e-4a5a-a15d-863cb70919d8
Age for regular mammography is
20
30
40
50
2c
single
Screening mammography: For screening purpose it is done after 40 years. Early screening is indicated when there is family history of carcinoma breast or histological risk factor. Mammography before 35 years of age is usually not done unless there is a suspicious lump or a strong family history. Screening is done in asy...
Surgery
Endocrinology and breast
5ff73f66-7493-4d62-b776-9b6de7d5b4ad
The spine of the scapula can be palpated at which of the following level of veebrae?
T 1
T 3
T 5
T 7
1b
single
Spine of the scapula lies at the level of T3 veebrae. Scapular spine is seen on the posterior surface of the scapula and it expands into a terminal process called acromion process. The scapulae overlie the posterior poion of the thoracic wall, and cover the upper seven ribs. The superior angle of scapula can be palpate...
Anatomy
null
2438e28a-5db4-4f1e-bac9-b13a0567de8f
NAD acts as a cofactor for
Citrate synthetase
Isocitrate dehyrogenase
a ketoglutarate dehyrogenase
Malate dehydrogenase
1b
single
In the TCA cycle,Step 3. In the third step, isocitrate is oxidized and releases a molecule of carbon dioxide, leaving behind a five-carbon molecule--a-ketoglutarate. During this step, \text{NAD}^+NAD + N, A, D, sta superscript, plus, end superscript is reduced to form \text{NADH}NADHN, A, D, H. The enzyme catalyzing th...
Biochemistry
Metabolism of carbohydrate
f96ed7ff-a25e-4357-9306-6b77f1bf1f68
Criteria for a pancreas donor include:
No history of diabetes
No liver donation
No replaced hepatic aery vessels arising from the superior mesenteric aery (SMA)
No previous splenectomy
0a
single
- Combined liver-pancreas procurement should be routine, even if the right hepatic aery arises from the superior mesenteric aery. - In this situation, since the transplanted liver is the life-saving organ, the proximal superior mesenteric aery should remain with the liver and the distal superior mesenteric aery supplyi...
Surgery
Transplantation
b7d06c4c-1491-40b9-bb0e-9343e1dd98e8
Indication for intramuscular iron therapy is
Oral desforaxamine
Oral deferiprone
Intramuscular EDTA
Oral succimer
1b
single
Refer KDT 6/e p 868 Drug of choice for acute iron poisoning is desferroxamine, however it has to be admistered parentarally It is not effective by oral route In beta thalassemia major iron excess can result due to repeated blood transfusions and massive Hemolysis Cheating agent has to be admistered for long time OK thi...
Pharmacology
Respiratory system
ecc6fb58-587e-49a4-9e21-d059c182c641
Beta 2 selective agonist are often effective in
Angina due to cornary insufficiency
Asthama
Delayed labour
All the above
1b
multi
Ref-KDT 6/e p127 Beta 2 agonist are useful in premature uterine contraction to delay labour and not for delayed labour. Beta blockers are used in the treatment of the angina
Anatomy
Other topics and Adverse effects
07666a33-5e16-4d46-a1f9-e8219a56054b
Which of the following refers to the occurrence of hypehyroidism following administration of supplemental iodine to subjects with endemic iodine deficiency goiter?
Jod-Basedow effect
Wolff-Chaikoff effect
Thyrotoxicosis Factitia
De Quervain's Thyroiditis
0a
single
Jod Basedow Effect: Refers to induction of thyrotoxicosis by iodine in the form of dietary supplements or medication, especially especially in patients who are relatively iodide deficient. Treatment includes combination of antithyroid drugs and perchlorate paicularly in amiodarone-induced thyrotoxicosis. Ref: Harrison'...
Medicine
null
632e3de5-908a-4af2-a33b-1595137fc78f
Seoli cells play a key role in which of the following process
Spermiogenesis
Testosterone secretion
Secretion of seminal fluid
Production of germ cells
0a
single
Seoli cells are elongated cells in the seminiferous tubules that ensheathe spermatogenic cells, providing a microenvironment that suppos spermiogenesis and spermatocytogenesis; they secrete androgen-binding protein and establish the blood-testis barrier by forming tight junctions with adjacent Seoli cells.Ref: Ganong&;...
Physiology
Endocrinology
5c9aed55-2802-46ae-8f55-7c96528e5deb
According to WHO, crede's method is applied for prophylactic use in ophthalmia neonatorum, is
Silver nitrate solution
Erythromycin ointment
Tetracycline ointment
Penicilline injection
0a
single
(Silver nitrate solution): Ref: 164-65-P, 71-KHOPHTHALMIA - NEONATORUM: any discharge or even watering from the eyes in the first week of life should arouse suspion of ophthalmia neonatorum* Use of either 1% tetracycline ointment or 0.5% erythromycin ointment or 1% silver nitrate solution (Crede's method) into the eyes...
Ophthalmology
Conjuctiva
91dc1d58-1676-468e-b070-c57d648e9f2c
A 6-week pregnant lady is diagnosed with sputum positive TB. Best management is -
Wait for 2nd trimester to start ATT
Start Category I ATT in first trimester
Start Category II ATT in first trimester
Start Category III ATT in second trimester
1b
single
Ans. is 'b' i.e., Start Category I ATT in first trimester * Tuberculosis during pregnancy should be diagnosed promptly and as early as possible. Late diagnosis and care is associated with 4-fold increase in obstetric morbidity and 9-fold increase in preterm labor.* Poor nutritional states, hypoproteinemia, anemia and a...
Gynaecology & Obstetrics
Miscellaneous (Gynae)
17f47413-489c-456f-95a4-d5d794aa601d
Commonest cause of acute intestinal obstruction is:
Adhesions
Volvulus
Inguinal hernias
Internal hernias
0a
single
SMALL BOWEL OBSTRUCTION - Adhesions secondary to previous surgery are the MC cause of SBO. - Causes: Adhesions (60%) > Malignant tumors (20%) >Hernia (10%) > Crohn's disease (5%)Q. - Primary colonic cancers (paicularly those arising from the cecum and ascending colon) may present as a SBO.
Surgery
Intestinal obstruction
8174ad90-afc8-4cc4-a906-87f9073a1f8b
The criteria for validity of a screening test are -
Accuracy
Predictability
Sensitivity & Specificity
Cost effectiveness
1b
single
Ans. is 'b' i.e., Predictability Screening test to be applied o The screening test to be applied should fulfil the following impoant criteria before it is considered suitable for screening : ? 1. Acceptability The test should be acceptable to the people at whom it is aimed. In general painful or embarrasing tests e.g.,...
Social & Preventive Medicine
null
503d8364-58ed-4605-9726-98f814409559
Aery supplying major pa of superolateral surface of brain is
Middle cerebral aery
Anterior cerebral aery
Posterior cerebral aery
Veebral aery
0a
single
The middle cerebral aery is the largest terminal branch of the internal carotid aery and it runs laterally in the lateral cerebral sulcus of the brain.It supplies the entire lateral surface of the cerebral hemisphere except the narrow strip along the superomedial border extending from the frontal pole to the parieto-oc...
Anatomy
null
8cce8415-daa7-4079-a3a4-cd68f91c832d
Double apical impulse is seen in?
HOCM
Cardiac tamponade
Aortic regurgitation
Pulmonary hypertension
0a
single
ANSWER: (A) HOCMREF: Harrison's 17th ed chapter 227"Most HOCM patients demonstrate a double or triple apical precordial impulse and a fourth heart sound. Those with intraventricular pressure gradients may have a rapidly rising arterial pulse. The hallmark of HOCM is a systolic murmur, which is typically harsh, diamond-...
Medicine
C.V.S.
ebb86720-905d-42e9-ae23-b852363cd97e
Tocilizumab used against Rheumatoid arthritis is a monoclonal antibody against :
Interleukin-6
Interleukin-6 receptor
Interleukin-5
Interleukin-5 receptor
0a
single
Monoclonal antibody against IL-6 : Tocilizumab                Monoclonal antibody against IL-6 receptor : Sarilumab Both are approved for Rheumatoid arthritis.
Pharmacology
null
dda9ad60-1b6c-46d7-abf5-b112219fcf45
One of the characteristic bedside features of Korsakoff's psychosis is-
Astereogenesis
Apraxia
Confabulation
Hallucination
2c
multi
null
Medicine
null
3f6a5045-4eb4-4e3e-9697-c731710159e4
Sequence which is responsible for retaining proteins in membrane
Translocon
Sec 61 complex
Docking protein
Halt signal
3d
single
D i.e. Halt signal
Biochemistry
null
dbe38f8b-26e8-4c5d-82a5-c2bfb32c8893
Most important amino-acid substrate for gluconeogenesis -
Leucine
Lysine
Histidine
Alanine
3d
single
Ans. is 'd' i.e., Alanine o The major noncarbohydrate precursors (substrate) for gluconeogenesis are lactate, pyruvate, glycerol, glucogenic amino acids, propionate and intermediates of the citric acid cycle. All aminoacids, exceptfor leucine and lysine, are substrate for gluconeogenesis. Alanine is the most important ...
Biochemistry
Amino Acids Basics
f973a066-51eb-4914-8306-e7e125a332af
Investigation of choice in appendicitis in adults
CT Scan
USG
Serum ESR
MRI Abdomen
0a
single
Answer- A. CT Scan
Surgery
null
b106fa7e-ab26-46f9-a3d5-84a8aa570f44
Lack of Leucocyte adhesion molecules (LAM) is associated with -
Delayed closure of umblical cord
Normal chemotaxis
Compliment opsinization
Neutropenia
0a
single
null
Medicine
null
eb216a2d-ec98-4e03-8ac8-de3c93bc6d1b
A 66 year old female is posted for subtotal gastrectomy for adenocarcinoma. The important procedure related complication:
Pneumothorax
Constipation
Hemolytic anemia
Bilious vomiting
3d
single
Ans. (d) Bilious vomitingRef: Sabiston 20th Edition, Page 1212Complications of Gastric Surgeries:* Dumping syndrome* Afferent loop syndrome* Efferent loop syndrome* Malabsorption syndrome (Anemia, hypocalcemia, B12 deficiency)* Alkaline reflux gastritis* Bile reflux gastritis* Gastric atony* Duodenal stump blow out.
Surgery
Stomach & Duodenum
4638f8c0-9dd9-4d3a-afdc-a10b00029fc5
Treatment of TOF ?
Modified BT shunt
Fontan procedure
Glenn shunt
Rastelli operation
0a
single
Ans. is 'a' i.e., Modified BT shunt
Pediatrics
null
5286422d-9de6-4c71-a491-7267b79dc6ba
All of the following are cause of blood in stools in children except -
Meckels diveiculum
Carcinoma
Intussusception
Juvenile polyp
1b
multi
Ans. is 'b' i.e., Carcinoma
Surgery
null
444facf5-0bce-4548-821d-0cb8af2f2d15
Seoli cells secrete ?
Testosterone
Androgen
FSH
Inhibin
3d
single
Ans. is 'd' i.e., InhibinLeydig cells have receptors for LH and secrete androgens, i.e. Testosterone, dihydrotestosterone (DHT), androstenedione, and dehydroepiandrosterone (DHEA).Seoli cells have receptors for FSH and secrete ABP, inhibin and MIS. seoli cells also have receptor for testosterone.
Physiology
null
bc380d98-aad4-4e01-b466-fcbe853412c4
The term 'psychoanalysis' is associated with: March 2009
John Broadus Watson
Carl Gustav Jung
Sigmond Freud
Wilhelm Reich
2c
single
Ans. C: Sigmond Freud Psychoanalysis/Freudian psychology is a body of ideas developed by Austrian physician Sigmund Freud and continued by others. It is primarily devoted to the study of human psychological functioning and behavior, although it can also be applied to societies. Psychoanalysis has three applications: A ...
Psychiatry
null
58ad4600-071d-4d42-a83a-e98b9f5c705f
All the following can occur in a neonate for heat production except –
Shivering
Breakdown of brownfat with adrenaline secretion
Universal flexion like a fetus
Cutaneous vasoconstriction
0a
multi
"Always remember that newborn cannot produce heat by shivering." Thermogenesis in Newborn A newborn is more prone to develop hypothermia because of a large surface area per unit of body weight. A low birth weight baby has decreased thermal insulation due to reduced subcutaneous and brown fat.
Pediatrics
null
4d34f71e-b4cb-4b2f-b4ef-bc96bf049113
Muscle not included in Anterior compartment of thigh
lliacus
Sartorius
Gracilis
Rectus femoris
2c
single
Gracilis is a muscle of Medial compartment
Anatomy
null
52a0c3ef-8f2d-4999-8ed8-77de7d59982d
Ziemann's dots in RBC are seen in infection with
Pl vivax
Pl falciparum
Pl malaria
Pl ovale
2c
single
Ziemann dots in RBC-PL Malaria Schaffner dots in RBC- Pl vivax Accola rings-falciparum Ref: D.R. Arora. Medical parasitology 4th ed pg 108
Microbiology
parasitology
bacf14d5-2ae8-4c46-99eb-fd6fd4156d1e
Which of the following is not an example of Phase II drug metabolic reaction?
Acetylation
Sulfation
Decyclization
Methylation
2c
single
phase 1 reactions- oxidation, reduction, cyclization, decyclization and hydrolysis Phase II reactions: 1. Glucuronidation 2. Acetylation 3. Glutathione conjugation 4. Glycine conjugation 5. Sulfation 6. Methylation 7. Water conjugation Reference: Katzung Pharmacology; 13th edition; Chapter 4; Drug Biotransformation
Pharmacology
General anatomy
22019df1-e844-4ee0-86b1-6e832c91d23a
Which of the following is not true about tabes Dorsalis -
Seen in Neurosyphiilis
Deep tendon reflexes are brisk
Loss of vibration sense
Acute abdominal pain and visceral symptoms
1b
multi
Ans. is 'b' i.e., Deep tendon reflexes are brisk Tabes dorsaliso Usually develops 15 - 20 years after syphilis infectiono Major symptoms are- lightning pain, ataxia, urinary' incontinenceLightning paino Lightning or lancinating pain are sharp stabbing pain and brief like a flash of lightning.o More common in legs.o Are...
Medicine
Spinal Cord Diseases
78d08c3f-44b4-4b99-9389-30ebb087b04f
Necrotising lymphadenitis is seen with
Kimura disease
Kikuchi disease
Castle Man disease
Hodgkin's lymphoma
1b
single
null
Medicine
null
80572ed3-2941-47e1-b341-cac1fc3b5107
'Scalloping' of the edge of sigmoid colon on barium enema seen in:
Diveiculosis
Ulcerative colitis
Carcinoma colon
Pneumatosis intestinalis
3d
multi
Ans. Pneumatosis intestinalis
Radiology
null
c22d1d78-a64e-4066-b2cf-376bf07bdf62
The cutoff point of serum estrogen level for the diagnosis of ovarian failure:
10 pg/ml
20 pg/ml
30 pg/ml
40 pg/ml
1b
single
Diagnosis of menopause is from classical symptom of hot flush (50%) confirmed by elevated FSH levels to more than 100 mlU/ml and serum estradiol < 20 pg/ml.
Gynaecology & Obstetrics
null
21410650-b6bf-4c3f-8bb0-007d0fa6b98b
Post term pregnancy is the pregnancy which continues beyond: September 2006
274 days
284 days
294 days
304 days
2c
single
Ans. C: 294 days The normal duration of pregnancy is approximately 37 to 42 weeks, with the estimated due date at 40 weeks or 280 days from the first day of the last menstrual period. A postterm pregnancy/prolonged pregnancy/post maturity is one that has extended beyond 2 weeks of the expected date of delivery (beyond ...
Gynaecology & Obstetrics
null
facfee90-11e8-4ce2-a5c0-82710b5261d7
A 45-year-old man is admitted to the hospital with breathing problems. During physical examination the patient shows signs of airway obstruction. A CT scan examination reveals a nasal polyp obstructing the airway. Drainage from which of the following structures is also obstructed?
Sphenoid sinus
Maxillary sinus
Ethmoidal sinus
Frontal sinus
1b
single
(b) Source: GAS 797, 879, 1018, 1020, 1022; GA 487, 518, 525 The nasal polyp also involved the maxillary sinus, located immediately laterally to the nasal cavity. The sphenoid sinus, located posterosuperiorly to the nasopharynx, is unlikely to be affected by a nasal polyp. The ethmoidal sinuses, located medially to the...
Anatomy
Head & Neck
4b27fc61-89bb-44bb-a286-ccb418622a3d
Gene associated with autosomal dominant breast cancer?
PTEN and KAI
BRCA 1 and 2
APC
P53
1b
single
Ans. B. BRCA 1. (Ref. Bailey and Love 26th/pg. 817)The BRCA1 gene has been associated with an increased incidence of breast (and ovarian) cancer and is located on the long arm of chromosome 17 (17q). The gene frequency in the population is approximately 0.0006. It does, however, occur with greater frequency in certain ...
Surgery
Breast
53357344-ac6c-4f51-b325-c57ef0148986
A 35-year-old lady presents with vaginal discharge. Smears from vaginal discharge show presence of?
Trichomonas
Entamoeba Histiolytica
Toxoplasma
Giardia
0a
single
Ans-A Trichomonas VaginalisThe image shows the presence of the anaerobic flagellated protozoan parasite, which causes vaginitis in women with the development of greenish malodorous discharge.
Unknown
null
650debb1-0bee-4a55-a072-7f549690d93c
A mother brings her 1 year old child to the hospital with complaints that he turns blue while breastfeeding. It resolves when he assumes a squatting position. On examination, a cleft palate is seen. Labs show hypocalcemia. Which of the following abnormalities are expected to be seen in the lymphoid organs?
Decreased size of periaeriolar lymphoid sheath of spleen
Increased size of spleenic follicles
Increased size of para coical areas of lymph nodes
Decreased size of germinal centres of lymph nodes
0a
single
Decreased size of paracoical areas of lymph nodes is expected as this child has DiGeorge Syndrome. DiGeorge Syndrome: Deficient CMI is seen due to aplasia of thymus and hence deficiency of T cells. This leads to paracoical areas of lymph nodes and periaeriolar sheaths of the spleen being reduced in size. B cells are us...
Microbiology
Immunology
3b2c63e7-4da7-42d2-b8fb-67ff0cdf1c06
Length of Posterior vaginal wall is
Variable
Same as anterior vagina wall
Less than anterior vagina wall
More than anterior vagina wall
3d
multi
The anterior wall of the vagina is about 8 cm long and the posterior wall about 10 cm long. ref - BDC 6e vol2 pg 393
Anatomy
Abdomen and pelvis
20911c3b-6e7d-415d-822f-7165f1e27074
Austin flint murmur is seen in cases of
Aortic stenosis
Aortic regurgitation
Hypertrophic obstructive cardiac myopathy
Ventricular stenosis
1b
single
The Austin Flint murmur of chronic severe AR is a low-pitched mid to late apical diastolic murmur that sometimes can be confused with MS. The Austin Flint murmur typically decreases in intensity after exposure to vasodilators, whereas the murmur of MS may be accompanied by an opening snap and also may increase in inten...
Medicine
null
e492f3b1-ffdc-4524-9ee3-fb0b76399e95
HBV replication is indicated by -a) HBV DNAb) DNA polymerasec) HBeAgd) Anti-HBe
abc
bc
acd
bcd
0a
single
null
Medicine
null
904f526a-6a9f-4e49-a7a5-d6bbbf449dde
Pheochromocytoma is associated with -
Vitiligo
Cafe-au-lait spots
Ash leaf amelanotic macusles
Acanthosis Nigricans
1b
single
Ans. is 'b' i.e., Cafe-au-lait spots o About 25-33% of patients with a pheochromocytoma or paraganglioma have an inherited syndrome.# Neurofibromatosis type 1 (NF1) was the first described pheochromocytoma-associated syndrome.o The NF1 gene functions as a tumor suppressor by regulating the Ras signaling cascade. Classi...
Medicine
Endocrinology
2472904e-ec5a-425e-82c3-7970030122dd
Not a feature of brain death
Complete apnea
Absent Pupillary reflex
Absence deep tendon reflex
Hea rate un-responsive to atropine
3d
single
The structural and functional damage of brain-stem may be diagnosed depending upon the following observations: Dilated fixed pupils, not responding to sharp changes in intensity of incident light. Absence of motor responses within the cranial nerve distribution on painful stimulation. Absence of corneal reflexes. Abse...
Forensic Medicine
All India exam
786d23a7-7ed4-4f89-b62c-11ed1b16ad48
Squamous cell carcinoma on tongue most common site is
Apex
Base
Lateral borders
Dorsum
2c
single
null
Pathology
null
cab9ac8a-cc6f-4d3f-bd27-38bf324b2813
False statement regarding adductor pollicis muscle:
Has 2 heads
Supplied by Median nerve
Causes Adduction of thumb
Arterial supply is from Arteria priceps pollicis
1b
multi
Ans: B (Supplied by Median nerve) Ref : Gray s Anatomy, 39th edition, 2008.Page.918Explanation:Adductor pollicis:Has 2 heads, i) Obi ique head ii) Transverse headOblique head: Origin from capitate, bases of 2nd, & 3rd metacarpal bonesTransverse head: Origin from palmar surface of 3rd metacarpal honeInsertion: Two heads...
Anatomy
Hand
b0665dd4-9301-45ba-842b-de34ba80abcf
Testing for microdeletion of Y-chromosome is offered for which patient with a normal Karyotype
Sperm concentration of 2 million/ml
Semen volume of 2 ml
Presence of fructose in semen
Normal morphology sperms >4%
0a
single
A patient with severely decreased sperm counts and a normal Karyotype is offered testing for microdeletion of Y chromosome.
Gynaecology & Obstetrics
null
1e2ec312-45ca-487f-859b-2115f248ee1e
True statement regarding insulin:
Produced by alpha cells of pancreas
Two polypeptide chains are bound by disulfide linkages
Shifts potassium outside the cell
S.c insulin tl/2 is 60 mins
1b
multi
Ref: Harper's Illustrated Biochemistry,28th editionExplanation:InsulinSecreted from pancreatic islet b cellsReleased regulated by blood (glycemic thresholdSynthesized as a single chain : pro-insulinInsulin is formed from proinsulin (removal of the connecting or "C" peptide)Insulin is thus made up of 2 chainsA (21 amino...
Biochemistry
Chemistry of Carbohydrates, Amino sugars, and Mucopolysaccharides
012f16b6-454e-47ea-be80-045e81ea4ba6
Internal carotid artery is derivative of
First pharyngeal arch
Third pharyngeal arch
Fourth pharyngeal arch
Sixth pharyngeal arch
1b
single
null
Anatomy
null
b2064efb-9890-49c3-8a47-7b3f51315c8a
Nipple shadows in chest xray characteristically have a sharp
Medial margin
Lateral margin
Superior margin
Inferior margin
1b
multi
Miller et al proposed that solitary pulmonary nodules that reach some or all of the following criteria can be considered nipple shadows :Bilateral and symmetric"fuzzy" margins or radiolucent "halo"Sharp lateral border and poorly defined medial border (may be present only on pa projections 3)Nodules are in a characteris...
Radiology
All India exam
cadf8a35-bbee-49b9-a54c-b855ae257161
What changes the conformation of alpha helix in collagen
Methionine
Proline
Alanine
Tyrosine
1b
single
Ans. (b) ProlineRef: Harper's Biochemistry, 30th ed. pg. 141, 298-99* Proline is the amino acid which changes the conformation of the alpha helix in collagen due to the nature of proline having a cyclical structure. It also forms the ends of the beta sheets in the secondary structures.
Biochemistry
Proteins and Amino Acids
80c83132-0c7b-452d-8218-757339c85c3d
Disruption or disorganization of biological rhythm is observed in
Schizophrenia
Anxiety
Depression
Mania
2c
single
Disturbance of biological functions is common with depression, with insomnia (or sometimes increased sleep), loss of appetite and weight (or sometimes hyperphagia and weight gain), and loss of sexual drive. When the disturbance is severe, it is called as melancholia ( somatic syndrome) The somatic syndrome in depressio...
Psychiatry
Mood disorders
9fc273b2-34fa-4e59-8b46-7c0fe32fed5f
All of the following are features of musculocutaneous nerve injury at axilla except
Loss of flexion of shoulder
Weak elbow flexion
Weak forearm supination
Loss of sensation on radial side of forearm
0a
multi
Loss of flexion of shoulder* Flexion at shoulder is done by major muscles like pectoralis major, anterior fibres of deltoid, which are intact here. Musculocutaneous nerve (MCN)originates from the lateral cord of the brachial plexus of nerves. It pierces the coracobrachialis muscle and gives off branches to the muscle, ...
Surgery
null
fa78e93d-8507-4de8-80e2-10025371faa9
Material used in veebroplasty:
Polymethyl methacrylate
IsoMethyl Methacry]ate
Isoethyl Methacrylayte
Silicon
0a
single
Ans. Polymethyl methacrylate
Radiology
null
bb9e9fc3-46aa-409a-bd4e-b18725e775d0
Paramesonephric duct in males remains as
Prostatic utricle
Prostatic uretha
Colliculus seminalis
Ejaculatory duct
0a
single
The paramesonephric ducts remain rudimentary in the maleThe greater pa of each duct eventually disappearsThe cranial end of each duct persists as a small rounded body attached to the testis(appendix of testis)It has been considered that the prostatic utricle represents the uterovaginal canalRef: Inderbir Singh&;s Human...
Anatomy
General anatomy
5aee74ad-3d07-4020-b50e-4d93d852b1d3
Following injury to the right temple region, patient complaints of pain in the right eye and loss of vision. On examination the eye movements are normal, and pupil normally reacts to light. The diagnosis is
Functional loss of vision
Optic nerve atrophy
Traumatic glaucoma
Sub-arachnoid haemorrhage
2c
multi
(C) Traumatic glaucoma# Traumatic Glaucoma: Atraumatic separation to the iris root and citiary body. Is not an uncommon cause of trauma by blunt object or by penetrating injury to globe.> Symptoms: Pain, blurred vision, history of blunt and penetrating injury.> Sings: Hyphaema, an irregular pupil in acute phase, slight...
Surgery
Miscellaneous
c8801c78-9276-47ac-aa92-0ce05792dc4a
Under EMCP launched in 1997,the criteria for selection of PHCs included the following EXCEPT:
API more than 2 for the last 3 years
Plasmodium falciparum more than 30% of total malaria cases
The area has been reporting deaths
The area has been reporting epidemics
3d
multi
Under EMCP (Enhanced Malaria Control Project) launched in 1997, the criteria for selection of PHCs (Primary Health Center) include API more than 2 for the last 3 years, Plasmodium falciparum more than 30% of total malaria cases and the area has been reporting deaths.
Unknown
null
6cfbc54b-6e9d-4284-8208-301a0c0c93f7
All of the following statements about purification of water are true except :
Presence of Clostridial spores indicate recent contamination of water
Coliforms must not be detectable in any 10 ml sample of drinking water
Sodium thiosulphate is used to neutralize chlorine.
Coliforms may be detected by multiple method & indole production
0a
multi
Spores of Cl. perfrignence (in the absence of coliform group) indicate remote fecal contamination of water. Total coliform bacteria must not be detectable in any 100 ml of sample. Sodium thiosulphate is used to dechlorinate tap water for aquariums or treat effluent from waste water treatments prior to release into rive...
Social & Preventive Medicine
null
28cf27d2-a2cf-4885-8bf1-35771a6545c5
In rhinosporidiosis the following is true:
Fungal granuloma
Greyish mass
Surgery is the treatment
Radiotherapy is treatment
2c
multi
(c) Surgery is the treatment(Ref. Scott Brown, 6th ed., 4/8/40)Rhinosporidiosis is managed by wide excision and cauterisation of base. Recurrence may occur if sporangium is left behind. Dapsone is given in the postoperative period to decrease the chances of recurrence.
ENT
Rhinosporidiosis
1a5c58ea-02c5-444a-be0f-3a8d582b190b
A 45-year-old woman is admitted to the emergency department with a complaint of severe abdominal pain. CT scan and MRI examinations reveal a tumor of the head of the pancreas involving the uncinate process. Which of the following vessels is most likely to be occluded?
Common hepatic artery
Cystic artery and vein
Superior mesenteric artery
Inferior mesenteric artery
2c
single
The superior mesenteric artery arises from the aorta, deep to the neck of the pancreas, then crosses the uncinate process and third part of the duodenum. An uncinate tumor can cause compression of the superior mesenteric artery. The common hepatic artery arises superior to the body of the pancreas and is unlikely to be...
Anatomy
Abdomen & Pelvis
c87967c4-06df-4c85-a2a2-0ecfb060fd61
Among various glands, salivary gland secretion is unique in that, its secretions are controlled by
Hormones
Nerves
Chemicals
All of the above
1b
multi
null
Dental
null
7f1aea67-72b4-4833-94ff-f4562c59933a
A 35-year-old man presents with following problem. Most likely diagnosis?
Cellulitis
Deep vein thrombosis
Gout
PAN
2c
single
Ans. C. Gouta. Acute gout causing swelling, erythema and extreme pain and tenderness of the first metatarsophalangeal joint.b. This is also known as Podagra- Colchicine and indomethacin are the drug of choice in this acute attack.
Medicine
Immunology and Rheumatology
2331335a-1845-45b5-bf35-4dbc770018a4
All of the following passthrough lesser sciatic foramen except:
Pudendal nerve
Internal pudendal vessels
Nerve to obturatorinternus
Inferior gluteal vessels
1b
multi
Internal pudendal vessels
Anatomy
null
4d06b572-fb1a-46a0-903d-6a439ad69c8a
Extrapyramidal side effects of antipsychotics -a) Dystoniab) Akathisiac) Seizuresd) Diarrheae) Parkinsonism
abc
bcd
abe
acd
2c
single
Extrapyramidal side effects of antipsychotics Extrapyramidal side effects are the major dose limiting side effects of antipsychotics. Maximum extrapyramidal side effects are seen with haloperidol. Least extrapyramidal side effects are seen with clozapine (amongst all antipsychotics). Among typical antipsychotics, thi...
Psychiatry
null
10679cc4-20b7-4a3e-a10a-f273865c34b7
Hard exudates are seen in the following except
Hypeensive retinopathy
Diabetic retinopathy
Exudative retinopathy of Coat's
Leukemic retinopathy
3d
multi
Leukaemic retinopathy It is characterised by pale and orange fundus background with dilated and touous veins. In later stages, greyish white lines may be seen along the course of the veins (due to perivascular leukaemic infiltration). Aerioles become pale and narrow. Retinal haemorrhages with typical white centre (Roth...
Ophthalmology
Cornea and sclera
3b40b5c2-df3d-4b66-9db6-d55e9574b592
A newborn child presents with inverted foot and the dorsum of the foot cannot touch the anterior tibia. The most probable diagnosis is:
Congenital vertical talus
Arthrogryposis Multiplex
CTEV
Cerebral palsy
2c
single
Ans. c. CTEV (Ref: Apley's 9/e p291, 591-594; Turek's 6/e p658-661; Campbell's 11/e p1474-1475)The most probable diagnosis in a newborn child with inverted foot in whom the dorsum of the foot cannot touch the anterior tibia is CTEV.Congenital Talipes EquinoVarus (CTEV):Congenital deformity involving one foot or both.Af...
Orthopaedics
Lower Limb and Foot & Ankle Problems
7d499d38-8956-41d8-841b-e7440b64d4c8
Increase in body temp during ovulation is by -
Estrogen
Progesterone
LH
FSH
1b
single
Ans. is 'b' i.e., Progesterone o Ovulation mav be inferred bv measuring the basal body temperature throuehout the menstrual cycle.o Temperature recordings are done on a chart and sustained upward shift of temperature (0.3degrees F for three days) infers that progesterone is being synthesized and released into circulati...
Gynaecology & Obstetrics
Pathology of Conception
96f7144f-23c6-46bc-b5f0-7c3dfefb031e
Replacement of etonogestrel implant(Implanon) is normally done after how many years?
2 years
3 years
4 years
5 years
1b
multi
Implanon is a single rod subdermal implant with 68 mg of the progestin etonogestrel (ENG), and an ethylene vinyl acetate copolymer cover. It can be used as contraception for 3 years and then replaced at the same site or opposite arm. It is placed in the medial surface of the upper arm 6 to 8 cm from the elbow in the bi...
Gynaecology & Obstetrics
null
a6a1fb5c-28b8-431d-9be0-ffdb727b4aba
True morbidity in a population can be calculated by
Sentinel Surveillance
Passive Surveillance
Active Surveillance
Monitoring
2c
multi
Active Surveillance Extra measures are taken to collect data and confirm diagnoses to ensure more complete repos for surveys and outbreak investigations. Active surveillance encompasses formal and informal communications. Eg: Malaria surveillance by a health worker Main objectives of Surveillance 1. Provide information...
Social & Preventive Medicine
Concept of health and disease