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Mechanisms and clinical management of inherited channelopathies: long QT syndrome, Brugada syndrome, catecholaminergic polymorphic ventricular tachycardia, and short QT syndrome. The following briefly reviews features and management of long QT syndrome (LQTS), Brugada Syndrome, catecholaminergic polymorphic ventricular... | Could Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
cause sudden cardiac death? | 52e8e96698d023950500001f_005 | yes |
Molecular spectrum and differential diagnosis in patients referred with sporadic or autosomal recessive osteogenesis imperfecta. BACKGROUND: Osteogenesis imperfecta (OI) is a heterogeneous bone disorder characterized by recurrent fractures. Although most cases of OI have heterozygous mutations in COL1A1 or COL1A2 and s... | Is autosomal dominant inheritanced form of Osteogenesis imperfecta caused by mutations in the genes associated with collagen production? | 5a6f77d7b750ff4455000051_014 | yes |
Proteome of formalin-fixed paraffin-embedded pancreatic ductal adenocarcinoma and lymph node metastases. Pancreatic ductal adenocarcinoma (PDAC) is a major cause of cancer-related death, largely due to metastatic disease. To better understand PDAC metastatic spread and identify novel therapeutic targets, we analysed th... | Is it possible to determine the proteome of a formalin fixed and paraffin embedded (FFPE) tissue? | 511a1e12df1ebcce7d000009_007 | yes |
Large-scale genome-wide association analysis of bipolar disorder identifies a new susceptibility locus near ODZ4. We conducted a combined genome-wide association study (GWAS) of 7,481 individuals with bipolar disorder (cases) and 9,250 controls as part of the Psychiatric GWAS Consortium. Our replication study tested 34... | Is there any association of the chromosomal region harboring the gene ITIH3 with schizophrenia? | 54d63d873706e89528000006_004 | yes |
Risk of progression from undifferentiated arthritis to rheumatoid arthritis: the effect of the PTPN22 1858T-allele in anti-citrullinated peptide antibody positive patients. OBJECTIVES: Anti-citrullinated peptide antibodies (ACPA) and the C1858T missense single-nucleotide polymorphism (SNP) in the PTPN22 gene are both a... | Is the PTPN22 gene a biomarker for Rheumatoid Arthritis? | 52e7870a98d023950500001a_010 | yes |
Radiological malformations of the ear in Pendred syndrome. Pendred syndrome comprises the association of severe congenital sensorineural deafness with thyroid pathology. Although it is the commonest form of syndromic hearing loss, the primary genetic defect remains unknown. The variable clinical presentation allied to ... | Do patients with Pendred syndrome present congenital deafness? | 56d8b27651531f7e33000003_014 | yes |
In vivo transcriptional profiling of Yersinia pestis reveals a novel bacterial mediator of pulmonary inflammation. UNLABELLED: Inhalation of Yersinia pestis results in primary pneumonic plague, a highly lethal and rapidly progressing necrotizing pneumonia. The disease begins with a period of extensive bacterial replica... | Does Yersinia pestis causes a respiratory infection? | 58caf86f02b8c60953000030_003 | yes |
Plasma magnesium concentrations and clinical outcomes in aneurysmal subarachnoid hemorrhage patients: post hoc analysis of intravenous magnesium sulphate for aneurysmal subarachnoid hemorrhage trial. BACKGROUND AND PURPOSE: Conflicting data have been obtained on optimal plasma magnesium concentrations for clinical outc... | Does magnesium sulfate improve outcomes of subarachnoid hemorrhage patients? | 54d62ede3706e89528000002_025 | no |
Autophagy and bacterial clearance: a not so clear picture. Autophagy, an intracellular degradation process highly conserved from yeast to humans, is viewed as an important defence mechanism to clear intracellular bacteria. However, recent work has shown that autophagy may have different roles during different bacterial... | Is autophagy the process where bacteria ingest viral particles? | 58dd2cb08acda34529000029_003 | yes |
Comparison of gamma glutamyltransferase in normal and in type 2 diabetics. OBJECTIVE: Comparison of gamma glutamyltransferase in normal and type 2 diabetics. METHODS: In a cross-sectional study, 100 apparently normal healthy subjects and, 47 type 2 diabetic subjects were selected from either sex with ages between 18-65... | SGOT is an abbreviation for an enzyme other wise known as alanine amino transferase, yes or no? | 5a67b48cb750ff4455000010_001 | no |
Biosynthesis of N-acetyldopamine and N-acetyloctopamine by Schistocerca gregaria nervous tissue. N-Acetyltyramine, N-acetyldopamine and N-acetyloctopamine were the major products when either L-[3H]tyrosine or [3H]tyramine were incubated with thoracic ganglia of the desert locust, Schistocerca gregaria. No label was inc... | Is NSD-1015 an inhibitor of Aromatic L-Amino Acid Decarboxylase? | 589c334e78275d0c4a00003d_014 | yes |
Topoisomerase 1 provokes the formation of short deletions in repeated sequences upon high transcription in Saccharomyces cerevisiae. High transcription is associated with genetic instability, notably increased spontaneous mutation rates, which is a phenomenon termed Transcription-Associated-Mutagenesis (TAM). In this s... | Is transcription-associated mutagenesis (TAM) related to gene expression levels? | 5544f3005beec11c10000008_003 | yes |
Autonomic dysfunction in pathologically confirmed multiple system atrophy and idiopathic Parkinson's disease--a retrospective comparison. INTRODUCTION: Autonomic dysfunction (AD) can be a feature of both multiple system atrophy (MSA) and idiopathic Parkinson's disease (IPD), conditions that are frequently misdiagnosed ... | Do Parkinson's disease patients experience stridor? | 54d8d4d1014675820d000006_004 | yes |
Endopeptidase activities of botulinum neurotoxin type B complex, holotoxin, and light chain. Botulinum neurotoxin (BoNT) serotype B (BoNT/B) is one of the serotypes of BoNT that causes deadly human botulism, though it is used clinically for treatment of many neuromuscular diseases. BoNT/B is produced by Clostridium bot... | Is the toxin produced by Clostridium botulinum always deadly? | 58a341a660087bc10a000017_006 | no |
Auto-antibodies, HLA and PTPN22: susceptibility markers for rheumatoid arthritis. OBJECTIVE: To analyse the relationship between the presence of auto-antibodies [rheumatoid factor (RF) and anti-cyclic citrullinated peptide (anti-CCP)], HLA-DRB1 alleles and PTPN22 1858 C/T polymorphism and test the value of their combin... | Is the PTPN22 gene a biomarker for Rheumatoid Arthritis? | 52e7870a98d023950500001a_040 | yes |
Surgical treatment of female stress urinary incontinence with a trans-obturator-tape (T.O.T.) Uratape: short term results of a prospective multicentric study. OBJECTIVE: The aim of the study was to assess the efficacy and safety of a new minimally invasive surgical procedure using the Trans-Obturator-Tape Uratape to tr... | Has silicon been used in treatment of incontinence ? | 536172d17d100faa09000009_000 | yes |
Hypertrophy and heart failure in mice overexpressing the cardiac sodium-calcium exchanger. BACKGROUND: The cardiac sodium-calcium exchanger (NCX1) is a key sarcolemmal protein for the maintenance of calcium homeostasis in the heart. Because heart failure is associated with increased expression of NCX1, heterozygous (HE... | Is Calcium homeostasis important in cardiac physiology and pathophysiology? | 54c26e29f693c3b16b000003_007 | yes |
Propranolol for treatment of infantile hemangiomas. Infantile hemangioma is the most common vascular tumor in early childhood. Propranolol has been successfully used recently in a limited number of children with Infantile hemangioma. We present 6 cases of Infantile hemangioma, at a single dermatological center, which r... | Is propranolol used for treatment of infantile hemangioma? | 5a67a72fb750ff445500000a_010 | yes |
ML-18 is a non-peptide bombesin receptor subtype-3 antagonist which inhibits lung cancer growth. Bombesin receptor subtype (BRS)-3 is a G protein coupled receptor (GPCR) for the bombesin (BB)-family of peptides. BRS-3 is an orphan GPCR and little is known of its physiological role due to the lack of specific agonists a... | Are the human bombesin receptors, GRPR and NMBR, frequently overexpressed G-protein-coupled-receptors by lung-cancers? | 5a8dc57ffcd1d6a10c000025_002 | yes |
Truncation of the deubiquitinating domain of CYLD in myelomonocytic cells attenuates inflammatory responses. The cylindromatosis tumor suppressor (CYLD) is a deubiquitinating enzyme that has been implicated in various aspects of adaptive and innate immune responses. Nevertheless, the role of CYLD in the function of spe... | Is the protein product of the cylindromatosis gene (CYLD) a deubiquitinating enzyme? | 550aef0ec2af5d5b7000000a_007 | yes |
Structural and immunocytochemical studies on alpha-N-acetylgalactosaminidase deficiency (Schindler/Kanzaki disease). Alpha-N-acetylgalactosaminidase (alpha-NAGA) deficiency (Schindler/Kanzaki disease) is a clinically and pathologically heterogeneous genetic disease with a wide spectrum including an early onset neuroaxo... | Is Kanzaki disease associated with deficiency in alpha-N-acetylgalactosaminidase? | 56f7c44109dd18d46b000013_004 | yes |
Circadian gene mPer2 overexpression induces cancer cell apoptosis. The Period2 gene, an indispensable component of the circadian clock, not only modulates circadian oscillations, but also regulates organic function. We examined whether overexpression of the mouse Period2 gene (mPer2) in tumor cells influences cell grow... | Is c-myc subject to regulation by the circadian clock? | 531616bdb166e2b806000003_004 | yes |
Solitary fibrous tumor of the meninges: a lesion distinct from fibrous meningioma. A clinicopathologic and immunohistochemical study. Seven solitary fibrous tumors (SFTs) of the meninges are presented and their clinicopathologic features are compared with those of 64 fibrous meningiomas (FM). Patients with SFT included... | Are psammoma bodies characteristic to meningiomas? | 514a4679d24251bc0500005b_014 | yes |
Phase I pharmacokinetic and pharmacodynamic study of recombinant human endostatin in patients with advanced solid tumors. PURPOSE: Endostatin is the first endogenous angiogenesis inhibitor to enter clinical trials. Laboratory investigations with endostatin have indicated broad antitumor activity coupled with remarkably... | Is endostatin a proangiogenic factor? | 53124e84e3eabad02100000c_001 | no |
A Case of Systemic Lupus Erythematosus Presenting as Guillain-Barré Syndrome. Systemic lupus erythematosus (SLE) is an autoimmune systemic disease with multiple organ involvement with high morbidity and mortality rate. Among the severe potential fatal complications are those of the central and peripheral nervous system... | Is the Miller-Fisher syndrome considered to be a variant of Guillain-Barré? | 571f59cd0fd6f91b68000008_012 | yes |
Reconstitution of the cytoplasmic interaction between phospholamban and Ca(2+)-ATPase of cardiac sarcoplasmic reticulum. Phospholamban (PLN) reversibly inhibits the Ca(2+)-ATPase of cardiac sarcoplasmic reticulum (SERCA2a) through a direct protein-protein interaction, playing a pivotal role in the regulation of intrace... | Does Serca2a bind PLN in the heart? | 51680b05298dcd4e51000064_006 | yes |
The Sirt1 activator SRT3025 provides atheroprotection in Apoe-/- mice by reducing hepatic Pcsk9 secretion and enhancing Ldlr expression. AIMS: The deacetylase sirtuin 1 (Sirt1) exerts beneficial effects on lipid metabolism, but its roles in plasma LDL-cholesterol regulation and atherosclerosis are controversial. Thus, ... | Does PCSK9 (Proprotein convertase subtilisin/kexin type 9) binds with HDL-receptor (HDL-R)? | 58db9aa28acda34529000018_019 | no |
Radiotherapy plus nimotuzumab or placebo in the treatment of high grade glioma patients: results from a randomized, double blind trial. BACKGROUND: The prognosis of patients bearing high grade glioma remains dismal. Epidermal Growth Factor Receptor (EGFR) is well validated as a primary contributor of glioma initiation ... | Does nimotuzumab improve survival of glioblastoma patients? | 54d901ec4b1fd0d33c000006_000 | yes |
Effects of a single post-partum injection of a high dose of vitamin D on glucose tolerance and insulin resistance in mothers with first-time gestational diabetes mellitus. AIM: This study was performed to determine the effect of a single, large, intramuscular injection of vitamin D post-partum on glucose tolerance and ... | Is Vitamin D deficiency in pregnant women associated with gestational diabetes? | 515def40298dcd4e51000028_016 | yes |
Dynamic interaction between the dual specificity phosphatase MKP7 and the JNK3 scaffold protein beta-arrestin 2. JNK scaffold proteins bind JNK and upstream kinases to activate subsets of JNK and localize activated JNK to specific subcellular sites. We previously demonstrated that the dual specificity phosphatases (DSP... | Is protein M3/6 a dual specificity phosphatase? | 5512cce26a8cde6b7200000c_008 | yes |
[Between symbol and symptom: pain and its meanings in classical antiquity]. According to semiotics, which may be defined as the doctrine of the essential nature and fundamental varieties of signs, objects, and interpretants, pain is considered to be a sign (significant) with very different meanings (significance) eithe... | Is Loss of function one of the cardinal signs of inflammation? | 5a7a44b4faa1ab7d2e000010_001 | yes |
Phenothiazines induce PP2A-mediated apoptosis in T cell acute lymphoblastic leukemia. T cell acute lymphoblastic leukemia (T-ALL) is an aggressive cancer that is frequently associated with activating mutations in NOTCH1 and dysregulation of MYC. Here, we performed 2 complementary screens to identify FDA-approved drugs ... | Are Notch mutations related to T-cell Acute Lymphoblastic Leukemia (T-ALL)? | 5522fadb7b523f2123000001_005 | yes |
Growth factor independent-1 maintains Notch1-dependent transcriptional programming of lymphoid precursors. Growth factor independent 1 (Gfi1) is a transcriptional repressor originally identified as a gene activated in T-cell leukemias induced by Moloney-murine-leukemia virus infection. Notch1 is a transmembrane recepto... | Are Notch mutations related to T-cell Acute Lymphoblastic Leukemia (T-ALL)? | 5522fadb7b523f2123000001_017 | yes |
Hyperkalemia complicating propranolol treatment of an infantile hemangioma. Propranolol treatment was recently reported to be successful for the management of severe infantile hemangioma. Known adverse effects of propranolol treatment include transient bradycardia, hypotension, hypoglycemia, and bronchospasm (in patien... | Is propranolol used for treatment of infantile hemangioma? | 5a67a72fb750ff445500000a_015 | yes |
Mutation analysis of the RET, the endothelin-B receptor, and the endothelin-3 genes in sporadic cases of Hirschsprung's disease. To date, three genes have been identified as susceptibility genes for Hirschsprung's disease (HSCR), the RET proto-oncogene, the endothelin-B receptor gene (EDNRB) and the endothelin-3 gene (... | Are EDNRB mutations involved in the development of Hirschsprung disease? | 551910c5622b194345000007_023 | yes |
DNA repair gene XRCC3 polymorphisms and bladder cancer risk: a meta-analysis. The X-ray repair cross-complementing group 3 (XRCC3) in homologous recombination repair (HRR) pathway plays a vital role in DNA double-strand break repair (DSBR). Variants in the XRCC3 gene might result in altered protein structure or functio... | Are defects in recombination repair involved in carcinogenesis? | 52f77f752059c6d71c00002b_005 | yes |
Recurrent inactivating RASA2 mutations in melanoma. Analysis of 501 melanoma exomes identified RASA2, encoding a RasGAP, as a tumor-suppressor gene mutated in 5% of melanomas. Recurrent loss-of-function mutations in RASA2 were found to increase RAS activation, melanoma cell growth and migration. RASA2 expression was lo... | Is RASA2 involved in melanoma? | 5896399978275d0c4a00000b_000 | yes |
Immune-mediated mechanisms in the pathoprogression of amyotrophic lateral sclerosis. Amyotrophic lateral sclerosis (ALS) is a devastating neurodegenerative disease with selective loss of upper and lower motor neurons. At sites of motor neuron injury, neuroinflammation is a prominent pathological finding and is characte... | Are immune cells affected in Amyotrophic Lateral Sclerosis? | 56cae51f5795f9a73e000025_000 | yes |
Inverse association between glutathione peroxidase activity and both selenium-binding protein 1 levels and Gleason score in human prostate tissue. BACKGROUND: Data from human epidemiological studies, cultured mammalian cells, and animal models have supported a potentially beneficial role of selenium (Se) in prostate ca... | Do selenoproteins and selenium play a role in prostate cancer prevention? | 515ed87c298dcd4e51000032_002 | no |
Paroxetine: safety and tolerability issues. Paroxetine is a selective serotonin re-uptake inhibitor (SSRI) available in immediate release and controlled release (CR) formulations. Paroxetine is the most potent inhibitor of serotonin re-uptake among the now available SSRIs. Paroxetine has been approved for the treatment... | Is paroxetine effective for treatment of premenstrual dysphoric disorder? | 514a59c2d24251bc0500005d_014 | yes |
Initial testing of the MDM2 inhibitor RG7112 by the Pediatric Preclinical Testing Program. BACKGROUND: RG7112 is a selective inhibitor of p53-MDM2 binding that frees p53 from negative control, activating the p53 pathway in cancer cells leading to cell cycle arrest and apoptosis. RG7112 was selected for evaluation by th... | Can RG7112 inhibit MDM2? | 56ed08062ac5ed1459000005_007 | yes |
Thyroid hormone analog 3,5-diiodothyropropionic acid promotes healthy vasculature in the adult myocardium independent of thyroid effects on cardiac function. Patients with hypothyroidism are at a higher risk for coronary vascular disease. Patients with diabetes and related vascular complications also have an increased ... | Is DITPA a thyroid hormone analog utilized in experimental and clinical studies | 52fb4b462059c6d71c00005f_001 | yes |
Chimeras of channelrhodopsin-1 and -2 from Chlamydomonas reinhardtii exhibit distinctive light-induced structural changes from channelrhodopsin-2. Channelrhodopsin-2 (ChR2) from the green alga Chlamydomonas reinhardtii functions as a light-gated cation channel that has been developed as an optogenetic tool to stimulate... | Is the optogenetics tool ChR2 light-sensitive? | 56e073ad51531f7e3300000e_006 | yes |
The next generation proteasome inhibitors carfilzomib and oprozomib activate prosurvival autophagy via induction of the unfolded protein response and ATF4. The proteasome inhibitor bortezomib has shown remarkable clinical success in the treatment of multiple myeloma. However, the efficacy and mechanism of action of bor... | Are proteasome inhibitors good candidates for treatment of leukemia and solid tumors? | 517179718ed59a060a00000e_003 | yes |
[Influence of genetic factors on development and severity of rheumatoid arthritis--part I]. Both genetic and environmental factors affect susceptibility, severity and probably drugs' efficacy in patients with rheumatoid arthritis (RA). After initial completion of the Human Genome Project on the 16th February 2001, sign... | Is the PTPN22 gene a biomarker for rheumatoid arthritis? | 52ffb5d12059c6d71c00007c_018 | yes |
Histomorphologic parameters and CXCR4 mRNA and protein expression in sentinel node melanoma metastasis are correlated to clinical outcome. INTRODUCTION: Sentinel lymph node (SLN) biopsy is an important independent prognostic factor for invasive cutaneuos melanoma, although its role is strongly debated. In clinical prac... | Is protein CXCR4 used as a prognostic marker of cancer? | 56e68967edfc094c1f000002_006 | yes |
Patients as collaborators: using focus groups and feedback sessions to develop an interactive, web-based self-management intervention for chronic pain. OBJECTIVES: To describe the development of an interactive, web-based self-management intervention for opioid-treated, chronic pain patients with aberrant drug-related b... | Are there web based self management strategies for chronic pain ? | 54fefff26ad7dcbc1200000b_004 | yes |
Intrinsic transcript cleavage in yeast RNA polymerase II elongation complexes. Transcript elongation can be interrupted by a variety of obstacles, including certain DNA sequences, DNA-binding proteins, chromatin, and DNA lesions. Bypass of many of these impediments is facilitated by elongation factor TFIIS through a me... | Does RNA polymerase II have RNA cleavage activity? | 5a468785966455904c00000d_008 | yes |
TLR9 is required for MAPK/NF-κB activation but does not cooperate with TLR2 or TLR6 to induce host resistance to Brucella abortus. Brucella abortus is a Gram-negative intracellular bacterial pathogen that causes a zoonosis of worldwide occurrence, leading to undulant fever in humans and abortion in domestic animals. B.... | Is Brucella abortus the organism that causes brucillosis known to cause spontaneous abortions in humans? | 5aa6800ad6d6b54f79000011_015 | no |
Ovarian endometriomas and IVF: a retrospective case-control study. We performed this retrospective case-control study analyzing 428 first-attempt in vitro fertilization (IVF) cycles, among which 254 involved women with a previous or present diagnosis of ovarian endometriosis. First, the results of these 254 cycles were... | Does surgery for ovarian endometriomas improve fertility? | 54f088ee94afd61504000015_000 | yes |
Mfd is required for rapid recovery of transcription following UV-induced DNA damage but not oxidative DNA damage in Escherichia coli. Transcription-coupled repair (TCR) is a cellular process by which some forms of DNA damage are repaired more rapidly from transcribed strands of active genes than from nontranscribed str... | Are there any functional differences between Mfd and its human Cocaine syndrome protein B (CSB) homolog? | 553f8bc11d53b76422000002_001 | yes |
Combination with bortezomib enhances the antitumor effects of nanoparticle-encapsulated thiostrepton. Bortezomib is well-known for inducing cell death in cancer cells, specifically through the mechanism of proteasome inhibition. Thiostrepton, a thiazole antibiotic, has also been described for its proteasome inhibitory ... | Are proteasome inhibitors good candidates for treatment of leukemia and solid tumors? | 517179718ed59a060a00000e_005 | yes |
[Members of the Vaccine Central Committee: a group of men deserving their native land and even humanity]. Two hundred years ago, in May 1800, a private initiative set up a "Central Committee of Vaccine" in Paris. A handful of men launched an extraordinary research: how to implement a still recent and little-known disco... | Has small pox been eradicated from the world? | 58a1da4e78275d0c4a000059_006 | yes |
Accumulation of p100, a precursor of NF-κB2, enhances osteoblastic differentiation in vitro and bone formation in vivo in aly/aly mice. We previously reported that alymphoplasia (aly/aly) mice, which have a natural loss-of-function mutation in the Nik gene, which encodes a kinase essential for the processing of p100 to... | Is p100 the precursor protein molecule of the NF-kappaB transcription factor subunit p50? | 55088e412e93f0133a000001_013 | no |
Weight gain associated with antipsychotic drugs. Weight gain has been reported with nearly every antipsychotic drug on the market (molindone is an exception). Weight gain occurs no matter what the patient's age, sex, or race and is seen with both oral and depot drug formulations. Numerous studies have found that patien... | Does molindone affect body weight? | 52cae04c03868f1b06000024_010 | yes |
Photoaging and tretinoin. Premature skin aging caused by repeated exposure to solar radiation is called photoaging. Although once considered an irreversible process, it is now established that photoaging can be treated by topical tretinoin. Both from carefully designed controlled clinical studies; and basic investigati... | Is tretinoin effective for photoaging? | 5a68f2bab750ff4455000017_007 | yes |
The SNORD115 (H/MBII-52) and SNORD116 (H/MBII-85) gene clusters at the imprinted Prader-Willi locus generate canonical box C/D snoRNAs. The imprinted Snurf-Snrpn chromosomal domain contains two large arrays of tandemly repeated, paternally expressed box C/D small-nucleolar RNA (snoRNA) genes: the SNORD115 (H/MBII-52) a... | Is the Snord116 cluster associated with the Prader-Willi syndrome? | 52b2f0d84003448f55000009_004 | yes |
Pharmacokinetics of 8-hour intravenous infusion of NXY-059: a phase I, randomized, double-blind (within dose panels), placebo-controlled study in healthy Chinese volunteers. BACKGROUND: NXY-059 is a free radical-trapping neuroprotectant that has been reported to reduce infarct size and preserve brain function in experi... | Can NXY-059 be used for treatment of acute ischemic stroke patients? | 54d62faf3706e89528000003_018 | no |
Extensive alternative polyadenylation during zebrafish development. The post-transcriptional fate of messenger RNAs (mRNAs) is largely dictated by their 3' untranslated regions (3' UTRs), which are defined by cleavage and polyadenylation (CPA) of pre-mRNAs. We used poly(A)-position profiling by sequencing (3P-seq) to m... | Is there alternative polyadenylation during zebrafish development? | 58963b0278275d0c4a00000c_000 | yes |
Differential effects of fingolimod on B-cell populations in multiple sclerosis. BACKGROUND: Fingolimod is an oral drug approved for multiple sclerosis (MS) with an ability to trap central memory T cells in secondary lymphoid tissues; however, its variable effectiveness in individual patients indicates the need to evalu... | Is there a relationship between B cells and Multiple Sclerosis? | 58c0836102b8c6095300001c_013 | yes |
Developmental determinants of the independence and complexity of the enteric nervous system. Enteric nervous system (ENS) development is relevant to Hirschsprung's disease (HSCR; congenital aganglionosis of the terminal bowel), which is still imperfectly treated. Mutations in genes encoding the RET receptor tyrosine ki... | Are EDNRB mutations involved in the development of Hirschsprung disease? | 551910c5622b194345000007_016 | yes |
[Schindler disease/Kanzaki disease]. Schindler disease and Kanzaki disease are caused by a deficient lysosomal enzyme, alpha-N-acetylgalactosaminidase (E.C.3.2.1.49). Two German children were first reported in 1987 and other two Dutch children were recently reported in 1993. These children were very similar clinically ... | Is Kanzaki disease associated with deficiency in alpha-N-acetylgalactosaminidase? | 56f7c44109dd18d46b000013_000 | yes |
The role of DNA repair by homologous recombination in oncogenesis. DNA repair by homologous recombination (HR) may be regarded as the two faces of a coin: lowering the oncogenetic potential (precise repair with no consequences on genomic status) or increasing it (deleterious action which may determine chromosome rearra... | Are defects in recombination repair involved in carcinogenesis? | 52f77f752059c6d71c00002b_003 | yes |
[Selenium deficiency in celiac disease: risk of autoimmune thyroid diseases]. The essential trace mineral selenium is of fundamental importance to human health. It is incorporated in the proteome in the forms of the genetically encoded amino acids selenocysteine and selenomethionine, which are the characteristic compon... | Is selenium deficiency involved in autoimmune thyroid disease? | 550c1ca3a103b78016000003_003 | yes |
[Safety of immunosuppressants]. METABOLISM: Cyclosporin A and leflunomide may increase the blood pressure, whereas administration of prednisolone and tacrolimus may cause hyperglycemia. Azathioprine, chloroquine, methotrexate and mycophenolate mofetil seem to be metabolically neutral. Tocilizumab and tumor necrosis fac... | Is it safe to use Abatacept during pregnancy? | 52bf1aa503868f1b06000006_000 | no |
Jarid2 links MicroRNA and chromatin in Th17 cells. In this issue of Immunity, Escobar et al. (2014) bring microRNAs and chromatin together by showing how activation-induced miR-155 targets the chromatin protein Jarid2 to regulate proinflammatory cytokine production in T helper 17 cells. | Is there any association between Jarid2 and miR-155 in Th17 cells? | 56b8f28a156496395c000006_001 | yes |
ZEB2 zinc-finger missense mutations lead to hypomorphic alleles and a mild Mowat-Wilson syndrome. Mowat-Wilson syndrome (MWS) is a severe intellectual disability (ID)-distinctive facial gestalt-multiple congenital anomaly syndrome, commonly associating microcephaly, epilepsy, corpus callosum agenesis, conotruncal heart... | Is Hirschsprung disease one of the characteristics of the Mowat-Wilson syndrome? | 55001420e9bde69634000005_007 | yes |
Over-expressing CYLD augments antitumor activity of TRAIL by inhibiting the NF-κB survival signaling in lung cancer cells. The death ligand tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) can selectively induce apoptosis in tumor cells. But studies have demonstrated that many tumor cells were resistant ... | Is there a role for the cylindromatosis tumor suppressor (CYLD) in lung cancer? | 5545e926d355485447000002_001 | yes |
Lenalidomide: targeted anemia therapy for myelodysplastic syndromes. Lenalidomide, an IMiD drug (a novel type of immunomodulating drug) was recently approved by the US Food and Drug Administration for the treatment of transfusion-dependent anemia in patients with myelodysplastic syndromes (MDS) and interstitial deletio... | Has Revlimid been approved by the US Food and Drug Administration? | 56ed0ba22ac5ed1459000007_006 | yes |
Cardiovascular Profile of Propranolol after Multiple Dosing in Infantile Hemangioma. Propranolol is becoming the treatment of choice for complicated infantile hemangioma. We report here data on peripheral blood flow, O2-saturation, electrocardiographic PR-interval, left ventricular function, blood pressure and heart ra... | Is propranolol used for treatment of infantile hemangioma? | 5a67a72fb750ff445500000a_009 | yes |
Comparison of pharmacological activity of macitentan and bosentan in preclinical models of systemic and pulmonary hypertension. AIMS: The endothelin (ET) system is a tissular system, as the production of ET isoforms is mostly autocrine or paracrine. Macitentan is a novel dual ETA/ETB receptor antagonist with enhanced t... | Is macitentan an ET agonist? | 56c863385795f9a73e000015_002 | no |
Effects of dexmedetomidine on adrenocortical function, and the cardiovascular, endocrine and inflammatory responses in post-operative patients needing sedation in the intensive care unit. We have compared the effects of dexmedetomidine and propofol on endocrine, metabolic, inflammatory and cardiovascular responses in p... | Is Propofol used for short-term sedation? | 515d9a42298dcd4e5100000d_009 | yes |
Absence of sensory neuropathy among workers with occupational exposure to chlorpyrifos. Several studies have reported the occurrence of sensory neuropathy with exposure to chlorpyrifos and other organophosphorus insecticides, at levels not associated with overt toxicity. We evaluated 113 chemical workers, including 53 ... | Is pesticide exposure associated with polyneuropathy? | 530cefaaad0bf1360c000010_005 | yes |
Chronic systemic administration of serotonergic ligands flibanserin and 8-OH-DPAT enhance HPA axis responses to restraint in female marmosets. BACKGROUND: Flibanserin, a novel serotonin (5-HT)(1A) agonist and 5-HT(2A) antagonist, has been shown to increase sexual desire and reduce distress in women with Hypoactive Sexu... | Is flibanserin effetive for Hypoactive Sexual Desire Disorder? | 56bb6b0eac7ad1001900000e_002 | yes |
Gene silencing of MIR22 in acute lymphoblastic leukaemia involves histone modifications independent of promoter DNA methylation. Aberrant epigenetic regulation has recently been implicated in the downregulation of tumour suppressor microRNAs (miRNAs). Histone modification and DNA methylation can have different roles in... | Are microRNA (miR) regulated through DNA methylation of their promoters? | 53636e727d100faa0900000d_002 | yes |
Nonpharmacologic approach to fatigue in patients with cancer. Cancer-related fatigue is a common yet underappreciated problem with a significant impact on functional ability and quality of life. Practice guidelines mandate that all cancer patients and survivors be screened for cancer-related fatigue (CRF) at regular in... | Can cognitive behavioral therapy improve fatigue in cancer patients? | 54d762653706e89528000014_016 | yes |
Awakenings and awareness recovery in disorders of consciousness: is there a role for drugs? Disorders of consciousness (DOC) include coma, vegetative state (VS) and minimally conscious state (MCS). Coma is a condition of unarousability with a complete absence of wakefulness and awareness, whereas VS is characterized by... | Is amantadine effective for treatment of disorders conciousness? | 530f7cdde3eabad021000001_004 | yes |
Elevated quantitative vibrotactile threshold among workers previously poisoned with methamidophos and other organophosphate pesticides. To evaluate chronic effects of acute organophosphate pesticide poisoning, quantitatively determined vibrotactile thresholds were measured as an index of peripheral neuropathy among agr... | Is pesticide exposure associated with polyneuropathy? | 530cefaaad0bf1360c000010_022 | yes |
Phenotypic spectrum of disorders associated with glycyl-tRNA synthetase mutations. We describe clinical, electrophysiological, histopathological and molecular features of a unique disease caused by mutations in the glycyl-tRNA synthetase (GARS) gene. Sixty patients from five multigenerational families have been evaluat... | Have mutations in the GARS gene been identified to cause Charcot-Marie-Tooth Disease Type 2D (CMT2D)? | 52b2ecd34003448f55000003_006 | yes |
Flibanserin: initial evidence of efficacy on sexual dysfunction, in patients with major depressive disorder. INTRODUCTION: Flibanserin, a novel 5-HT(1A) agonist and 5-HT(2A) antagonist, has the potential to treat sexual dysfunction. AIM: Provide historical perspective on the rationale for development of flibanserin to ... | Is flibanserin effetive for Hypoactive Sexual Desire Disorder? | 56bb6b0eac7ad1001900000e_004 | yes |
Lipoplex mediated silencing of membrane regulators (CD46, CD55 and CD59) enhances complement-dependent anti-tumor activity of trastuzumab and pertuzumab. The therapeutic potential of anticancer antibodies is limited by the resistance of tumor cells to complement-mediated attack, primarily through the over-expression of... | Is HER2 active only when it dimerizes? | 5509ec41c2af5d5b70000006_005 | yes |
Atrial natriuretic peptide as a marker for doxorubicin-induced cardiotoxic effects. Doxorubicin is an effective antineoplastic agent, but it frequently causes dose-related cardiotoxic effects. Because the atrial natriuretic peptide (ANP) level is elevated in children with heart defects, the authors measured the ANP lev... | Is Doxorubicin cardiotoxic? | 58cdb80302b8c60953000043_019 | yes |
DNA-methylation effect on cotranscriptional splicing is dependent on GC architecture of the exon-intron structure. DNA methylation is known to regulate transcription and was recently found to be involved in exon recognition via cotranscriptional splicing. We recently observed that exon-intron architectures can be group... | Is DNA methylation correlated with nucleosome occupancy? | 5a43a214966455904c000009_004 | yes |
Loss of productivity due to depression among Korean employees. OBJECTIVES: The aim of this study was to investigate the difference in productivity between those who are depressed and those who are not. METHODS: A cross-sectional study of depressive and non-depressive employees at a workplace was performed. Data was col... | Is there an association between presenteeism and depression? | 54f49e56d0d681a040000004_003 | yes |
Nifedipine, an L-type calcium channel blocker, restores the hypnotic response in rats made tolerant to the alpha-2 adrenergic agonist dexmedetomidine. Rats were made tolerant to the hypnotic effects of the alpha-2 adrenergic agonist dexmedetomidine by a 7- or 14-day continuous systemic administration of the same, and t... | Does nifedipine inhibit L-type calcium channels? | 56c313d150c68dd416000002_009 | yes |
[The Supernatant Obtained from Cultured Anip973 Cells Enhances the Biological Activities of HUVEC]. BACKGROUND AND OBJECTIVE: Unlike normal tissue-derived microvascular endothelial cells, tumor microvessel endothelial cells are highly reactive to growth factors and exhibit more adhesion molecules. Thus, vascular tumors... | Is Annexin V an apoptotic marker? | 5894597e7d9090f353000004_008 | yes |
Nystagmus: an uncommon neurological manifestation of thiamine deficiency as a serious complication of sleeve gastrectomy. Wernicke encephalopathy--a debilitating acute or subacute neurological disorder-is caused by a deficiency in thiamine (vitamin B(1)). It is characterized by a classical clinical triad of symptoms: o... | Can vitamin B1 deficiency cause encephalopathy? | 572211540fd6f91b68000016_011 | yes |
Characterizing ligands for farnesoid X receptor--available in vitro test systems for farnesoid X receptor modulator development. INTRODUCTION: Farnesoid X receptor (FXR) is an ascending target for metabolic and inflammatory diseases. As a nuclear receptor, FXR exhibits many physiological effects in transcription contro... | Is farnesoid X receptor (FXR) a nuclear receptor? | 55263a1898daae017c000001_006 | yes |
Tele-pain management: use of videoconferencing technology in the delivery of an integrated cognitive-behavioral and physical therapy group intervention. Chronic pain has been recognized as a highly prevalent problem, and interdisciplinary treatments have been shown to be effective in the treatment of chronic pain. An i... | Are there telemedicine applications for chronic pain management? | 54ff106b6ad7dcbc1200000c_004 | yes |
The direct factor Xa inhibitor rivaroxaban. Warfarin and heparin are the traditional mainstay anticoagulant therapies for treating thromboembolic disease. These drugs, with a documented history of utility, also have inherent difficulties in usage; in particular, the complicated monitoring and numerous drug-drug interac... | Are there any specific antidotes for rivaroxaban? | 532f08b8d6d3ac6a34000029_009 | no |
Tumor suppression and circadian function. Circadian clock and cell division cycle are two fundamental biological processes. The circadian clock is the body's molecular time-keeping system, while the cell division cycle regulates development and cellular renewal. The expression of cell cycle genes such as Wee1, Cyclins,... | Is c-myc subject to regulation by the circadian clock? | 531616bdb166e2b806000003_009 | yes |
Effect of AZD1480 in an epidermal growth factor receptor-driven lung cancer model. OBJECTIVE: STAT3 plays a vital role in inducing and maintaining a pro-carcinogenic inflammatory microenvironment and is reported to be a critical mediator of the oncogenic effects of EGFR mutations. STAT3 activation is mediated through J... | Is signal transducer and activator of transcription-3 (STAT3) critical for tumor angiogenesis progression? | 533d0f44c45e13371400000e_006 | yes |
Current perspective new insights into the molecular basis of familial dilated cardiomyopathy. Genetic disease transmission has been identified in a significant proportion of patients with dilated cardiomyopathy (DCM). Variable clinical characteristics and patterns of inheritance, as well as recent molecular genetic dat... | Is desmin an intermediate filament protein involved in Dilated Cardiomyopathy (DCM)? | 55031963e9bde6963400002a_001 | yes |
Optimizing the purification and analysis of miRNAs from urinary exosomes. BACKGROUND: Exosomes are cytoplasm containing vesicles released by many cells that can be found in several biological fluids including urine. Urinary exosomes are released from every segment of the nephron, are detectable in urine, constitutively... | Can exosomes be detected in urine? | 550895c12e93f0133a000002_002 | yes |
Six-month paroxetine treatment of premenstrual dysphoric disorder: continuous versus intermittent treatment protocols. AIMS: Several trials have proved the efficacy of selective serotonin re-uptake inhibitors (SSRI) in the treatment of premenstrual dysphoric disorder (PMDD) in Western society. The SSRI can be administe... | Is paroxetine effective for treatment of premenstrual dysphoric disorder? | 514a59c2d24251bc0500005d_006 | yes |
The molecular autopsy: an indispensable step following sudden cardiac death in the young? Annually thousands of sudden deaths involving young individuals (<35 years of age) remain unexplained following a complete medicolegal investigation that includes an autopsy. In fact, epidemiological studies have estimated that ov... | Could Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
cause sudden cardiac death? | 52e8e96698d023950500001f_026 | yes |
Proteomics applied to the study of platelet-related diseases: aiding the discovery of novel platelet biomarkers and drug targets. Platelets play a fundamental role in hemostasis. Because they do not have a nucleus, proteomics is an ideal way to approach their biochemistry. Platelet proteomics is still a young field tha... | Can we use platelet biomarkers to study Alzheimer's disease? | 530b4f49970c65fa6b00000a_002 | yes |
Natural variation for alleles under epigenetic control by the maize chromomethylase zmet2. The contribution of epigenetic alterations to natural variation for gene transcription levels remains unclear. In this study, we investigated the functional targets of the maize chromomethylase ZMET2 in multiple inbred lines to d... | Are chromomethylases present in animal genomes? | 5171833c8ed59a060a00000f_004 | no |
Indistinguishable patterns of protooncogene expression in two distinct but closely related tumors: Ewing's sarcoma and neuroepithelioma. Genetic characterization of human tumors promises new insights of biological importance and clinical relevance. We have found that two solid tumors, peripheral neuroepithelioma and Ew... | Is peripheral neuroepithelioma related to Ewing sarcoma? | 552fa6f5bc4f83e828000002_008 | yes |
Maternal and paternal thrombophilia: risk factors for perinatal mortality. BACKGROUND: Although some paternal components to the predisposition to pre-eclampsia have been demonstrated recently, it is not known whether such paternal factors play a role to thrombophilia-related perinatal mortality. OBJECTIVE: To compare t... | Is thrombophilia related to increased risk of miscarriage? | 513cdc38bee46bd34c000007_001 | yes |
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