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Serum selenium is low in newly diagnosed Graves' disease: a population-based study. CONTEXT: Selenium deficiency may play an important role in the initiation and progression of autoimmune thyroid disease. OBJECTIVE: To compare serum selenium (s-Se) values in patients with newly diagnosed autoimmune thyroid disease and ... | Is selenium deficiency involved in autoimmune thyroid disease? | 550c1ca3a103b78016000003_001 | yes |
Histone lysine-specific demethylase 1 (LSD1) protein is involved in Sal-like protein 4 (SALL4)-mediated transcriptional repression in hematopoietic stem cells. The stem cell protein SALL4 plays a critical role in hematopoiesis by regulating the cell fate. In primitive hematopoietic precursors, it activates or represses... | Is Lysine-specific demethylase 1 (LSD1) a critical regulator of hematopoiesis? | 553c011af321868558000009_001 | yes |
Measurements of TSC2 GAP activity toward Rheb. Tuberous sclerosis complex (TSC) is a genetic disease caused by mutation in either the tsc1 or tsc2 tumor suppressor genes. TSC1 and TSC2 protein form a physical and functional complex in vivo. Recent studies have demonstrated that TSC2 displays GTPase activating protein (... | Is Tuberous Sclerosis a genetic disease? | 52b06a68f828ad283c000005_017 | yes |
Confirmation of STAT4, IL2/IL21, and CTLA4 polymorphisms in rheumatoid arthritis. OBJECTIVE: Recent advances have led to novel identification of genetic polymorphisms that are associated with susceptibility to rheumatoid arthritis (RA). Currently, 5 loci (HLA, PTPN22, TRAF1/C5, TNFAIP3, and STAT4) have been consistentl... | Is the PTPN22 gene a biomarker for Rheumatoid Arthritis? | 52e7870a98d023950500001a_021 | yes |
Non-invasive prenatal testing for aneuploidy: current status and future prospects. Non-invasive prenatal testing (NIPT) for aneuploidy using cell-free DNA in maternal plasma is revolutionizing prenatal screening and diagnosis. We review NIPT in the context of established screening and invasive technologies, the range o... | Can fetal aneuploidy be detected with non-invasive prenatal testing? | 57136cbf1174fb1755000007_000 | yes |
Characterization of a novel mutation in the cardiac ryanodine receptor that results in catecholaminergic polymorphic ventricular tachycardia. Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an arrhythmogenic disease that manifests as syncope or sudden death during high adrenergic tone in the absence of ... | Could Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT) cause sudden cardiac death? | 530cf4fe960c95ad0c000003_011 | yes |
Is progesterone a worthy candidate as a novel therapy for traumatic brain injury? Although progesterone is critical to a healthy pregnancy, it is now known to have other important functions as well. Recent research demonstrates that this hormone is also a potent neurosteroid that can protect damaged cells in the centra... | Is progesterone effective for treatment of patients with traumatic brain injury based on clinical trial data? | 54cf48acf693c3b16b00000b_009 | no |
Therapeutic Fc-fusion proteins and peptides as successful alternatives to antibodies. Therapeutic antibodies have captured substantial attention due to the relatively high rate at which these products reach marketing approval, and the subsequent commercial success they frequently achieve. In the 2000s, a total of 20 an... | Has Denosumab (Prolia) been approved by FDA? | 52bf1db603868f1b06000011_010 | yes |
Biosensors for the Diagnosis of Celiac Disease: Current Status and Future Perspectives. Celiac disease (CD) is an autoimmune enteropathy initiated and sustained by the ingestion of gluten in genetically susceptible individuals. It is caused by a dysregulated immune response toward both dietary antigens, the gluten prot... | Is celiac disease caused by gliadin-induced transglutaminase-2 (TG2)-dependent events ? | 5a79d195faa1ab7d2e00000e_002 | yes |
Nucleosome positioning and kinetics near transcription-start-site barriers are controlled by interplay between active remodeling and DNA sequence. We investigate how DNA sequence, ATP-dependent chromatin remodeling and nucleosome-depleted 'barriers' co-operate to determine the kinetics of nucleosome organization, in a ... | Is nucleosome eviction ATP-dependent? | 532ff558d6d3ac6a34000037_001 | yes |
TNF-α-stimulated fibroblasts secrete lumican to promote fibrocyte differentiation. In healing wounds and fibrotic lesions, fibroblasts and monocyte-derived fibroblast-like cells called fibrocytes help to form scar tissue. Although fibrocytes promote collagen production by fibroblasts, little is known about signaling fr... | Is lumican a secreted protein? | 5ad255210340b9f058000018_003 | yes |
Sonidegib phosphate: new approval for basal cell carcinoma. Basal cell carcinoma (BCC), although mostly locally confined, is the most common cancer. Most BCCs harbor inactivating mutations in the membrane receptor/gene Ptch, thereby activating the Hedgehog signaling pathway (Hh) via the essential signaling molecule Smo... | Is sonidegib effective for basal cell carcinoma? | 589a246f78275d0c4a000034_000 | yes |
Glyburide is associated with attenuated vasogenic edema in stroke patients. BACKGROUND: Brain edema is a serious complication of ischemic stroke that can lead to secondary neurological deterioration and death. Glyburide is reported to prevent brain swelling in preclinical rodent models of ischemic stroke through inhibi... | Can glyburide reduce cerebral edema? | 588482f5e56acf517600000a_005 | yes |
Overexpression of long non-coding RNA HOTAIR predicts tumor recurrence in hepatocellular carcinoma patients following liver transplantation. BACKGROUND: The long noncoding RNA HOTAIR has been reported as a poor prognostic biomarker in patients with breast cancer. The aim of the present study is to examine the expressio... | Do lincRNAs play a role in human cancer? | 516e5f33298dcd4e5100007e_004 | yes |
Mechanism underlying catecholaminergic polymorphic ventricular tachycardia and approaches to therapy. Catecholaminergic polymorphic ventricular tachycardia (CPVT) is an inherited arrhythmia syndrome characterized by VT induced by adrenergic stress in the absence of structural heart disease and high incidence of sudden ... | Could Catecholaminergic Polymorphic Ventricular Tachycardia (CPVT)
cause sudden cardiac death? | 52e8e96698d023950500001f_006 | yes |
High-dose simvastatin for aneurysmal subarachnoid hemorrhage: a multicenter, randomized, controlled, double-blind clinical trial protocol. BACKGROUND: Experimental evidence has indicated the benefit of simvastatin in the treatment of subarachnoid hemorrhage. However, no clinical data are available to answer whether a h... | Is statin use associated with improved outcomes after aneurysmal subarachnoid hemorrhage? | 530e131b5937551c09000002_007 | yes |
Phospholamban knockout increases CaM kinase II activity and intracellular Ca2+ wave activity and alters contractile responses of murine gastric antrum. Phospholamban (PLB) inhibits the sarcoplasmic reticulum (SR) Ca(2+)-ATPase (SERCA), and this inhibition is relieved by Ca(2+) calmodulin-dependent protein kinase II (Ca... | Is phospholamban a regulatory/inhibitory protein of the Ca ATPase SERCA? | 5501b3b3e9bde69634000007_005 | yes |
Plant immunophilins: functional versatility beyond protein maturation. Originally identified as the cellular targets of immunosuppressant drugs, the immunophilins encompass two ubiquitous protein families: the FK-506 binding proteins or FKBPs, and the cyclosporin-binding proteins or cyclophilins. Present in organisms r... | Are cyclophilins ubiquitously expressed? | 56f6ab7009dd18d46b00000d_008 | yes |
Bapineuzumab and solanezumab for Alzheimer's disease: is the 'amyloid cascade hypothesis' still alive? INTRODUCTION: The 'amyloid cascade hypothesis' remains the leading hypothesis to explain the pathophysiology of Alzheimer's disease (AD). Immunotherapeutic agents have been developed to remove the neurotoxic amyloid β... | Is bapineuzumab effective for treatment of patients with Alzheimer's disease? | 530cefaaad0bf1360c000004_001 | no |
Medulloblastoma and glioblastoma multiforme in a patient with Turcot syndrome: a case report. BACKGROUND: Turcot syndrome (TS) or the glioma-polyposis syndrome, is a rare, heritable disorder thought by some authors to be a variant of familial adenomatous polyposis (FAP). It is characterized by central nervous system (C... | Is Turcot syndrome associated with glioblastoma? | 533581f5d6d3ac6a3400004d_009 | yes |
Reduced-nicotine content cigarettes: Is there potential to aid smoking cessation? INTRODUCTION: Current smoking cessation treatments largely address pharmacological dependence on nicotine. New approaches are needed that address both nicotine dependence and psychological dependence on cigarettes as the source of nicotin... | Are reduced-nicotine cigarettes effective for smoking cessation? | 56bc8d65ac7ad1001900001a_010 | yes |
Environmental exposures, epigenetics and cardiovascular disease. PURPOSE OF REVIEW: Epigenetic modifications are heritable alterations of the genome, which can govern gene expression without altering the DNA sequence. The purpose of this review is to render an overview of the possible mechanisms of epigenetic regulatio... | Are epigenetic modifications implicated in cardiovascular development and disease? | 54f7291630767eb92e000002_003 | yes |
T-cell prolymphocytic leukemia. T-cell prolymphocytic leukemia (T-PLL) is a rare aggressive post-thymic malignancy with poor response to conventional treatment and short survival. It can readily be distinguished from other T-cell leukemias on the basis of the distinctive morphology, immunophenotype, and cytogenetics. C... | Is alemtuzumab effective for remission induction in patients diagnosed with T-cell prolymphocytic leukemia? | 530cefaaad0bf1360c000001_007 | yes |
Simplified bladder training augments the effectiveness of tolterodine in patients with an overactive bladder. OBJECTIVES: To compare the efficacy of tolterodine plus simplified bladder training (BT) with tolterodine alone in patients with an overactive bladder. PATIENTS AND METHODS: In a multicentre, single-blind study... | Is Bladder training an effective method to treat urge incontinence ? | 515df98f298dcd4e51000030_011 | yes |
A phase II study of the combination of endocrine treatment and bortezomib in patients with endocrine-resistant metastatic breast cancer. The majority of patients with hormone receptor-positive metastatic breast cancer die from disease progression despite different types of anti-hormonal treatments. Pr... | Are proteasome inhibitors good candidates for treatment of leukemia and solid tumors? | 517179718ed59a060a00000e_007 | yes |
Foodborne botulism in Canada, 1985-2005. During 1985-2005, a total of 91 laboratory-confirmed outbreaks of foodborne botulism occurred in Canada; these outbreaks involved 205 cases and 11 deaths. Of the outbreaks, 75 (86.2%) were caused by Clostridium botulinum type E, followed by types A (7, 8.1%) and B (5, 5.7%). App... | Can botulism poisoning of a pregnant woman harm her fetus? | 554763f0f35db75526000002_000 | no |
Management of symptomatic vulvovaginal atrophy: 2013 position statement of The North American Menopause Society. OBJECTIVE: To update and expand the previous position statement of The North American Menopause Society (NAMS) on the management of symptomatic vulvovaginal atrophy (VVA) in postmenopausal women. METHODS: NA... | Is ospemifene effective for treatment of dyspareunia? | 5335b373d6d3ac6a34000050_007 | yes |
Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. BACKGROUND: The programmed death 1 (PD-1) receptor is a negative regulator of T-cell effector mechanisms that limits immune responses against cancer. We tested the anti-PD-1 antibody lambrolizumab (previously known as MK-3475) in patients with advan... | Is lambrolizumab effective for treatment of patients with melanoma ? | 530cefaaad0bf1360c000008_001 | yes |
Activation of p53 by the MDM2 inhibitor RG7112 impairs thrombopoiesis. The tumor suppressor p53 is thought to play a role in megakaryocyte (MK) development. To assess the influence of the p53 regulatory pathway further, we studied the effect of RG7112, a small molecule MDM2 antagonist that activates p53 by preventing i... | Can RG7112 inhibit MDM2? | 56ed08062ac5ed1459000005_002 | yes |
Limited functional redundancy and oscillation of cyclins in multinucleated Ashbya gossypii fungal cells. Cyclin protein behavior has not been systematically investigated in multinucleated cells with asynchronous mitoses. Cyclins are canonical oscillating cell cycle proteins, but it is unclear how fluctuating protein gr... | Has the fungus Ashbya gossypii got many nuclei that share cytoplasm? | 550e6688a103b7801600000d_001 | yes |
Molecular characterisation of gastrointestinal microbiota of children with autism (with and without gastrointestinal dysfunction) and their neurotypical siblings. Many children with autism spectrum disorders (ASDs) suffer from gastrointestinal problems such as diarrhoea, constipation and abdominal pain. This has stimul... | Is abdominal pain a common symptom in autism? | 515debe7298dcd4e51000026_000 | yes |
Investigation of telomere lengths measurement by quantitative real-time PCR to predict age. Currently DNA profiling methods only compare a suspect's DNA with DNA left at the crime scene. When there is no suspect, it would be useful for the police to be able to predict what the person of interest looks like by analysing... | Can chronological age be predicted by measuring telomere length? | 56d34fbcf22319765a000009_001 | no |
The in vivo kinetics of RNA polymerase II elongation during co-transcriptional splicing. RNA processing events that take place on the transcribed pre-mRNA include capping, splicing, editing, 3' processing, and polyadenylation. Most of these processes occur co-transcriptionally while the RNA polymerase II (Pol II) enzym... | Does splicing occur co-transcriptionally? | 533c3871c45e133714000007_003 | yes |
Effects of P2 purinergic receptor stimulation in brown adipocytes. Sympathetic stimulation of brown adipocytes plays a major role in body energy homeostasis by activating energy-wasting pathways. Sympathetic neuronal input initiates a variety of metabolic, developmental, and membrane responses in brown fat cells. Many ... | Do brown fat cells produce heat? | 58ca906a02b8c6095300002e_025 | yes |
Alzheimer's disease risk alleles in TREM2 illuminate innate immunity in Alzheimer's disease. Genetic studies have provided the best evidence for cause and effect relationships in Alzheimer's disease (AD). Indeed, the identification of deterministic mutations in the APP, PSEN1 and PSEN2 genes and subsequent preclinical ... | Is TREM2 associated with Alzheimer's disease? | 531a31a1b166e2b806000035_000 | yes |
Development of gene therapy for blood disorders: an update. This review addresses the current status of gene therapy for immunodeficiencies, chronic granulomatous disease, suicide gene therapy for graft-versus-host disease, viral infections, malignant hematologic disorders, hemophilia, and the hemoglobin disorders. New... | Are retroviruses used for gene therapy? | 52ce531f03868f1b06000031_005 | yes |
Syndromic and non-syndromic deafness, molecular aspects of Pendred syndrome and its reported mutations. Deafness means partial or complete hearing impairment and is one of the most prevalent sensory defects in humans. It can be due to genetic or environmental causes or a combination of both and may be Syndromic (associ... | Do patients with Pendred syndrome present congenital deafness? | 56d8b27651531f7e33000003_016 | yes |
Epistatic interactions with a common hypomorphic RET allele in syndromic Hirschsprung disease. Hirschsprung disease (HSCR) stands as a model for genetic dissection of complex diseases. In this model, a major gene, RET, is involved in most if not all cases of isolated (i.e., nonsyndromic) HSCR, in conjunction with other... | Is RET the major gene involved in Hirschsprung disease? | 5503121de9bde69634000019_012 | yes |
Rapid and Sensitive Multiplex Detection of Burkholderia pseudomallei-Specific Antibodies in Melioidosis Patients Based on a Protein Microarray Approach. BACKGROUND: The environmental bacterium Burkholderia pseudomallei causes the infectious disease melioidosis with a high case-fatality rate in tropical and subtropical ... | Is Melioidosis caused by the bacterium Burkholderia pseudomallei? | 58caf88c02b8c60953000031_048 | yes |
Clinical experience of treatment of metastatic melanoma and solid tumours adopting a derivative of diphtheria toxin: cross-reacting material 197. BACKGROUND: Diphtheria toxin (DT) has shown anticancer activity in both experimental models and humans but its adverse effects stopped further developments. Cross-reacting Ma... | Is fatigue prevalent in patients receiving treatment for glioblastoma? | 530e42e65937551c09000007_019 | yes |
The RNA polymerase of influenza virus, bound to the 5' end of virion RNA, acts in cis to polyadenylate mRNA. We previously demonstrated, by limited mutagenesis, that conserved sequence elements within the 5' end of influenza virus virion RNA (vRNA) are required for the polyadenylation of mRNA in vitro. To further chara... | Is polyadenylation a process that stabilizes a protein by adding a string of Adenosine residues to the end of the molecule? | 5a8714e261bb38fb24000005_023 | no |
Development and initial evaluation of a treatment decision dashboard. BACKGROUND: For many healthcare decisions, multiple alternatives are available with different combinations of advantages and disadvantages across several important dimensions. The complexity of current healthcare decisions thus presents a significant... | Are there any Decision support systems for chronic pain management ? | 54fefbbc6ad7dcbc1200000a_002 | yes |
Functional and clinical relevance of CD44 variant isoform expression on B-cell chronic lymphocytic leukemia cells. BACKGROUND AND OBJECTIVE: Recent studies have shown that expression of adhesion molecules of the Ig superfamily, of integrins and of selectins allows definition of high vs low risk B-cell chronic lymphocyt... | Are CD44 variants (CD44v) associated with poor prognosis of metastasis? | 533bf29cc45e133714000001_003 | yes |
Segregation analysis of brown oculocutaneous albinism. The segregation of brown (type IV) oculocutaneous albinism was analyzed in 18 Nigerian families. Analysis using the POINTER program showed that this type of oculocutaneous albinism was inherited in an autosomal recessive pattern, with an estimated gene frequency of... | Does oculocutaneous albinism show an autosomal recessive inheritance? | 58cbb55402b8c60953000033_005 | yes |
Global dinucleotide signatures and analysis of genomic heterogeneity. Early biochemical experiments measuring nearest neighbor frequencies established that the set of dinucleotide relative abundance values (dinucleotide biases) is a remarkably stable property of the DNA of an organism. Analyses of currently available g... | Can we detect DNA strand asymmetries using dinucleotide relative abundance "genomic signatures"? | 55435aeced966d112c000007_003 | no |
The Role of Cardiolipin in Cardiovascular Health. Cardiolipin (CL), the signature phospholipid of mitochondrial membranes, is crucial for both mitochondrial function and cellular processes outside of the mitochondria. The importance of CL in cardiovascular health is underscored by the life-threatening genetic disorder ... | Is diphosphatidylglycerol (cardiolipin) a phospholipid of the mitochondrial membranes? | 58d90f228acda3452900000f_010 | yes |
Osteoporosis in men: what has changed? Osteoporosis in men is finally receiving some attention; it has been realized that men are more likely to die after hip fracture. Methods for screening men for osteoporosis include dual energy x-ray absorptiometry and use of fracture risk calculators such as FRAX (World Health Org... | Has Denosumab (Prolia) been approved by FDA? | 52bf1db603868f1b06000011_019 | yes |
Signaling pathways in mitral valve degeneration. Heart valves exhibit a highly-conserved stratified structure exquisitely designed to counter biomechanical forces delivered over a lifetime. Heart valve structure and competence is maintained by heart valve cells through a process of continuous turnover extracellular mat... | Is there an association between carcinoid syndrome and mitral valve disease? | 5a67a550b750ff4455000009_005 | yes |
Inconsistency between glycemic and insulinemic responses to regular and fermented milk products. BACKGROUND: Foods with a low glycemic index are increasingly being acknowledged as beneficial in relation to the insulin resistance syndrome. Certain organic acids can lower the glycemic index of bread products. However, th... | Does cucumber lower blood sugar in diabetics? | 516c220e298dcd4e51000071_001 | yes |
Unusual association of ST-T abnormalities, myocarditis and cardiomyopathy with H1N1 influenza in pregnancy: two case reports and review of the literature. INTRODUCTION: Myocarditis is rarely reported as an extra-pulmonary manifestation of influenza while pregnancy is a rare cause of cardiomyopathy. Pregnancy was identi... | Is pregnancy an additional risk during during H1N1 infection? | 531a3fe3b166e2b806000038_007 | yes |
Design and validation of a neutral protein scaffold for the presentation of peptide aptamers. Peptide aptamers are peptides constrained and presented by a scaffold protein that are used to study protein function in cells. They are able to disrupt protein-protein interactions and to constitute recognition modules that a... | Can a peptide aptamer be used as protein inhibitor? | 53443b13aeec6fbd0700000e_009 | yes |
Fatal primary cutaneous cryptococcosis: case report and review of published literature. OBJECTIVE: Cryptococcus is an opportunistic yeast with a worldwide distribution that primarily causes significant infections in immunocompromised individuals, generally by affecting the respiratory tract. But primary cutaneous crypt... | Is Cryptococcus neoformans a frequent cause of isolated skin infections in immunocompromised individuals | 58e120036fddd3e83e00000d_000 | no |
Altered MicroRNA expression confined to specific epithelial cell subpopulations in breast cancer. MicroRNAs (miRNAs) are a new class of short noncoding regulatory RNAs (18-25 nucleotides) that are involved in diverse developmental and pathologic processes. Altered miRNA expression has been associated with several types... | Is miR-21 related to carcinogenesis? | 511a4ec01159fa8212000004_045 | yes |
Subacute Sclerosing Panencephalitis: The Devastating Measles Complication That Might Be More Common Than Previously Estimated. Background: Subacute sclerosing panencephalitis (SSPE) is a fatal complication of measles. We reviewed California cases from 1998-2015 to understand risk factors for SPPE and estimate incidence... | Is subacute sclerosing panencephalitis caused by the Measles vaccine? | 5aa3fa73d6d6b54f79000008_024 | no |
Synergistic killing effect between vorinostat and target of CD146 in malignant cells. PURPOSE: Although histone deacetylase inhibitors (HDACi) are emerging as a new class of anticancer agents, one of the most significant concerns is that interactions with a wide array of substrates using these agents might initiate bot... | Are histone deacetylase (HDAC) inhibitors good candidates to control metastasis of solid tumors? | 517404878ed59a060a000023_008 | yes |
Comprehensive ZEB2 gene analysis for Mowat-Wilson syndrome in a North American cohort: a suggested approach to molecular diagnostics. Mowat-Wilson syndrome is a genetic condition characterized by a recognizable facial phenotype in addition to moderate to severe cognitive disability with severe speech impairment and var... | Have mutations in the ZEB2 gene been found in any human syndrome? | 53552ed7f1005d6b58000001_002 | yes |
Young MLP deficient mice show diastolic dysfunction before the onset of dilated cardiomyopathy. Targeted deletion of cytoskeletal muscle LIM protein (MLP) in mice consistently leads to dilated cardiomyopathy (DCM) after one or more months. However, next to nothing is known at present about the mechanisms of this proces... | Is muscle lim protein (MLP) involved in cardiomyopathies? | 54f704b630767eb92e000001_005 | yes |
The serine/threonine kinase Ndr2 controls integrin trafficking and integrin-dependent neurite growth. Integrins have been implicated in various processes of nervous system development, including proliferation, migration, and differentiation of neuronal cells. In this study, we show that the serine/threonine kinase Ndr2... | Is the protein β1-integrin recycled? | 56e5b445edfc094c1f000001_001 | yes |
Trial of Tocilizumab in Giant-Cell Arteritis. BACKGROUND: Giant-cell arteritis commonly relapses when glucocorticoids are tapered, and the prolonged use of glucocorticoids is associated with side effects. The effect of the interleukin-6 receptor alpha inhibitor tocilizumab on the rates of relapse during glucocorticoid ... | Is Tocilizumab effective for Giant-Cell Arteritis? | 5a733d2a2dc08e987e000015_006 | yes |
ELMO1 and Dock180, a bipartite Rac1 guanine nucleotide exchange factor, promote human glioma cell invasion. A distinct feature of malignant gliomas is the intrinsic ability of single tumor cells to disperse throughout the brain, contributing to the failure of existing therapies to alter the progression and recurrence o... | Is Rac1 involved in cancer cell invasion? | 5319abc9b166e2b80600002d_015 | yes |
Effect of amiodarone and dronedarone administration in rats on thyroid hormone-dependent gene expression in different cardiac components. OBJECTIVE: In view of their different actions on thyroid hormone receptor (TR) isoforms we set out to investigate whether amiodarone (AM) and dronedarone (Dron) have different and/or... | Does amiodarone affect thyroid hormone receptors in the myocardium? | 516d5baa298dcd4e51000078_003 | yes |
Associations between lipid metabolism and fertility in the dairy cow. Dairy cows mobilise body tissues to support milk production and, because glucose supplies are limited, lipids are used preferentially for energy production. Lipogenic activity is switched off and lipolytic mechanisms in adipose tissue increase throug... | Has the protein TIEG1 been associated with apoptosis? | 53386282d6d3ac6a3400005a_013 | yes |
Differentiation of human pluripotent stem cells to retinal pigmented epithelium in defined conditions using purified extracellular matrix proteins. A potential application of human embryonic stem cells (hESCs) and induced pluripotent stem cells (iPSCs) is the generation of retinal pigmented epithelium (RPE) to treat ag... | Have hESC been tested for the treatment of age-related macular degeneration? | 56f553aa09dd18d46b000005_004 | yes |
The enhancer-blocking activity of the Fab-7 boundary from the Drosophila bithorax complex requires GAGA-factor-binding sites. In the work reported here we have analyzed the role of the GAGA factor [encoded by the Trithorax-like (Trl) gene] in the enhancer-blocking activity of Frontabdominal-7 (Fab-7), a domain boundary... | Is GAGA associated with nucleosome-free regions (NFR)? | 56f3f6b12ac5ed145900001a_001 | yes |
Phase II evaluation of gefitinib in patients with newly diagnosed Grade 4 astrocytoma: Mayo/North Central Cancer Treatment Group Study N0074. PURPOSE: Amplification of the epidermal growth factor receptor (EGFR) gene represents one of the most frequent gene alterations in glioblastoma (GBM). In the current study, we ev... | Is fatigue prevalent in patients receiving treatment for glioblastoma? | 530e42e65937551c09000007_000 | yes |
Protective role of three vegetable peels in alloxan induced diabetes mellitus in male mice. The hitherto unknown glucose regulating role of three vegetable peels from cucurbitaceae family was evaluated. In a preliminary study, effects of ethanolic extracts of Cucurbita pepo, Cucumis sativus and Praecitrullus fistulosus... | Does cucumber lower blood sugar in diabetics? | 516c220e298dcd4e51000071_003 | yes |
Nimodipine and nitrendipine inhibit N-type calcium channels in dibutyryl cAMP-differentiated neuroblastoma x glioma hybrid (NG 108-15) cells. The effects of nifedipine, niguldipine, nimodipine and nitrendipine on the high K+-induced intracellular Ca2+ ([Ca2+]i) transient in dibutyryl cAMP-differentiated neuroblastoma x... | Does nifedipine inhibit L-type calcium channels? | 56c313d150c68dd416000002_010 | yes |
Neonatal diabetes caused by a homozygous KCNJ11 mutation demonstrates that tiny changes in ATP sensitivity markedly affect diabetes risk. AIMS/HYPOTHESIS: The pancreatic ATP-sensitive potassium (KATP) channel plays a pivotal role in linking beta cell metabolism to insulin secretion. Mutations in KATP channel genes can ... | Can Diabetes be caused by a defect in a potassium chanel? | 58a0a28a78275d0c4a000051_000 | yes |
Anti-Müllerian hormone deficiency in females with Fanconi anemia. CONTEXT: In females with Fanconi anemia (FA), infertility is often accompanied by diminished ovarian reserve and hypergonadotropic amenorrhea before the age of 30 years, suggesting primary ovarian insufficiency (POI). POI is typically diagnosed only afte... | Is infertility characteristic of individuals with Fanconi anemia? | 58b6d26122d300530900000e_001 | yes |
The E3 SUMO ligase Nse2 regulates sumoylation and nuclear-to-cytoplasmic translocation of skNAC-Smyd1 in myogenesis. Skeletal and heart muscle-specific variant of the α subunit of nascent polypeptide associated complex (skNAC; encoded by NACA) is exclusively found in striated muscle cells. Its function, however, is lar... | Is sumoylation implicated in myogenesis? | 56cca4da5795f9a73e000034_002 | yes |
Dicer-2 processes diverse viral RNA species. RNA silencing pathways play critical roles in gene regulation, virus infection, and transposon control. RNA interference (RNAi) is mediated by small interfering RNAs (siRNAs), which are liberated from double-stranded (ds)RNA precursors by Dicer and guide the RNA-induced sile... | Is Dicer part of the RISC loading complex? | 5516fc8832767d0305000002_001 | yes |
A familial case of Muenke syndrome. Diverse expressivity of the FGFR3 Pro252Arg mutation--case report and review of the literature. Muenke is a fibroblast growth factor receptor 3 (FGFR-3)-associated syndrome, which was first described in late 1990 s. Muenke syndrome is an autosomal dominant disorder characterized main... | Is there an association between Muenke Syndrome and FGFR3 gene mutation? | 5895ec5e7d9090f353000015_008 | yes |
Oxidase-deficient neutrophils from X-linked chronic granulomatous disease iPS cells: functional correction by zinc finger nuclease-mediated safe harbor targeting. We have developed induced pluripotent stem cells (iPSCs) from a patient with X-linked chronic granulomatous disease (X-CGD), a defect of neutrophil microbici... | Can zinc finger nucleases be used to combat disease? | 56f15c5a2ac5ed1459000012_007 | yes |
Neuropsychiatric syndromes and occupational exposure to zinc phosphide in Egypt. Eighty-six workers exposed to zinc phosphide (Zn3P2) pesticide were studied for evidence of neuropsychiatric manifestations. They were evaluated clinically, by electroencephalography (EEG), and, in some cases, by electromyography (EMG). Al... | Is pesticide exposure associated with polyneuropathy? | 530cefaaad0bf1360c000010_011 | yes |
Two novel mutations of GARS in Korean families with distal hereditary motor neuropathy type V. Glycyl-tRNA synthetase (GARS), which encodes the enzyme responsible for charging tRNA(Gly) with glycine in both the cytoplasm and mitochondria, is implicated to Charcot-Marie-Tooth disease 2D (CMT2D) and distal hereditary mot... | Is glycyl-tRNA synthetase gene involved in the development of Charcot-Marie-Tooth disease? | 5713c4a11174fb1755000013_005 | yes |
The tumor suppressor role of CTCF. CTCF is an evolutionary conserved and ubiquitously expressed protein that binds thousands of sites in the human genome. Ectopic expression of CTCF in various normal and tumoral human cell lines inhibits cell division and clonogenicity, with the consequence to consider CTCF a potential... | Are CTCF and BORIS involved in genome regulation and cancer? | 56a375f8496b62f23f000002_002 | yes |
Validation and application of Drosophila melanogaster as an in vivo model for the detection of double strand breaks by neutral Comet assay. Comet assay under neutral conditions allows detection of DNA double-strand breaks (DSBs), which has consequence to genome instability and carcinogenesis. The present study aims to ... | Do DNA double-strand breaks play a causal role in carcinogenesis? | 5162f5b6298dcd4e5100004c_009 | yes |
Nocturnal cardiac arrhythmia in patients with obstructive sleep apnea. BACKGROUND AND PURPOSE: Nocturnal cardiac arrhythmias occur in patients with obstructive sleep apnea (OSA), reportedly as a consequence of the autonomic effects of recurrent apnea with subsequent oxygen desaturation. We have investigated whether dif... | Are sleep apnea and snoring associated with cardiac arrhythmias? | 5a981dd0fcd1d6a10c00002e_009 | yes |
MicroRNA and proteome expression profiling in early-symptomatic α-synuclein(A30P)-transgenic mice. The α-synuclein has been implicated in the pathophysiology of Parkinson's disease (PD), because mutations in the alpha-synuclein gene cause autosomal-dominant hereditary PD and fibrillary aggregates of alpha-synuclein are... | Is the microRNA 132 (miR-132) involved in brain pathologies? | 5156be5ed24251bc05000087_002 | yes |
Luteal phase administration of paroxetine for the treatment of premenstrual dysphoric disorder: a randomized, double-blind, placebo-controlled trial in Canadian women. OBJECTIVE: To evaluate the efficacy and safety of intermittent, luteal phase-only administration of paroxetine (10 mg and 20 mg) in the treatment of pre... | Is paroxetine effective for treatment of premenstrual dysphoric disorder? | 514a59c2d24251bc0500005d_007 | yes |
Using stem cells in multiple sclerosis therapies. Stem cell transplantation approaches offer for the first time the opportunity to design therapeutic approaches for multiple sclerosis (MS) with curative intent. Here we discuss key observations and questions emerging from clinical trials of hematopoietic stem cell trans... | Are there clinical trials on stem cells in multiple sclerosis | 515df5b2298dcd4e5100002c_004 | yes |
Clinical relationship between EDN-3 gene, EDNRB gene and Hirschsprung's disease. AIM: To investigate the mutation of EDNRB gene and EDN-3 gene in sporadic Hirschsprung's disease (HD) in Chinese population. METHODS: Genomic DNA was extracted from bowel tissues of 34 unrelated HD patients which were removed by surgery. E... | Are EDNRB mutations involved in the development of Hirschsprung disease? | 551910c5622b194345000007_017 | yes |
The relationship between protein C, protein S and cytokines in acute ischemic stroke. OBJECTIVE: The role of inflammation in the pathogenesis of acute ischemic stroke is well known, but its association with the clinical picture is as yet unclear. MATERIAL AND METHODS: In our study, we measured the serum levels of the p... | Is there an association between serum interleukin-6 concentrations and outcomes of stroke patients? | 54cf4bc3f693c3b16b00000d_002 | yes |
Treatment with propranolol for infantile hemangioma in 13 Taiwanese newborns and young infants. BACKGROUND: Hemangioma in infants has a benign self-limited course, but the 10% of cases with complications need further treatment. Successful treatment with propranolol in western countries has been reported over the past f... | Is propranolol used for treatment of infantile hemangioma? | 5a67a72fb750ff445500000a_014 | yes |
High-throughput screening for N-type calcium channel blockers using a scintillation proximity assay. N-type calcium channels located on presynaptic nerve terminals regulate neurotransmitter release, including that from the spinal terminations of primary afferent nociceptors. Accordingly, N-type calcium channel blockers... | Does ziconotide bind to N-type calcium channels? | 56cf27293975bb303a000003_003 | yes |
Focal adhesion proteins Zyxin and Vinculin are co-distributed at tubulobulbar complexes. Tubulobulbar complexes (TBCs) are actin-related double-membrane invaginations formed at intercellular junctions in the seminiferous epithelium of mammalian testis. They occur at basal junction complexes between neighboring Sertoli ... | Is zyxin a focal adhesion protein? | 54f4b319d0d681a040000005_002 | yes |
CD99 (MIC2) regulates the LFA-1/ICAM-1-mediated adhesion of lymphocytes, and its gene encodes both positive and negative regulators of cellular adhesion. Despite the fact that integrin-mediated lymphocyte adhesion is a crucial event for an appropriate immune response, little is known about the mechanisms that control t... | Is CD99 encoded by MIC2 gene? | 55376b37bc4f83e82800000b_011 | yes |
Positive regulation of osteogenesis by bile acid through FXR. Farnesoid X receptor (FXR) is a nuclear receptor that functions as a bile acid sensor controlling bile acid homeostasis. We investigated the role of FXR in regulating bone metabolism. We identified the expression of FXR in calvaria and bone marrow cells, whi... | Is farnesoid X receptor (FXR) a nuclear receptor? | 55263a1898daae017c000001_014 | yes |
Structure-function relation of phospholamban: modulation of channel activity as a potential regulator of SERCA activity. Phospholamban (PLN) is a small integral membrane protein, which binds and inhibits in a yet unknown fashion the Ca(2+)-ATPase (SERCA) in the sarcoplasmic reticulum. When reconstituted in planar lipid... | Is phospholamban a regulatory/inhibitory protein of the Ca ATPase SERCA? | 5501b3b3e9bde69634000007_010 | yes |
The mutation rate and cancer. The stability of the human genome requires that mutations in the germ line be exceptionally rare events. While most mutations are neutral or have deleterious effects, a limited number of mutations are required for adaptation to environmental changes. Drake has provided evidence that DNA-ba... | Does replication timing affect the rate of somatic mutations? | 5710dd61cf1c32585100002e_006 | yes |
Aptameric peptide for one-step detection of protein kinase. Protein kinases are significant regulators in the cell signal pathway, and it is difficult to achieve quick kinase detection because traditional kinase assays normally rely on a time-consuming kinase phosphorylation process. Herein, we present a novel one-step... | Can a peptide aptamer be used as protein inhibitor? | 53443b13aeec6fbd0700000e_007 | yes |
Disseminated septicaemic melioidosis: an unusual presentation of masticator space infection. Melioidosis is an infectious disease caused by a saprophytic bacterium, Burkholderia pseudomallei. It is endemic to Southeast Asia and Northern Australia. The spectrum of melioidosis in humans varies from sub-clinical to overwh... | Is Melioidosis caused by the bacterium Burkholderia pseudomallei? | 58caf88c02b8c60953000031_016 | yes |
DNA-Repair Defects and Olaparib in Metastatic Prostate Cancer. BACKGROUND: Prostate cancer is a heterogeneous disease, but current treatments are not based on molecular stratification. We hypothesized that metastatic, castration-resistant prostate cancers with DNA-repair defects would respond to poly(adenosine diphosph... | Is olaparib effective for prostate cancer? | 56c1f01eef6e394741000046_000 | yes |
Multiplex protein signature for the detection of bladder cancer in voided urine samples. PURPOSE: Accurate urine assays for bladder cancer detection would benefit patients and health care systems. Through extensive genomic and proteomic profiling of urine components we previously identified a panel of 8 biomarkers that... | Are there any urine biomarkers for bladder cancer diagnosis? | 52cb9b9b03868f1b0600002d_005 | yes |
A mutation in the human norepinephrine transporter gene (SLC6A2) associated with orthostatic intolerance disrupts surface expression of mutant and wild-type transporters. The norepinephrine transporter (NET) mediates reuptake of norepinephrine released from neurons, and, as such, it is an important regulator of noradre... | Is the gene SLC6A2 associated with orthostatic intolerance? | 56d8ba1851531f7e33000005_004 | yes |
HER2 testing by local, central, and reference laboratories in specimens from the North Central Cancer Treatment Group N9831 intergroup adjuvant trial. PURPOSE: To evaluate concordance between local and central laboratory HER2 testing results in patients from the North Central Cancer Treatment Group (NCCTG) N9831 adjuva... | Is there a pharmacogenetic test for trastuzumab? | 514a1469d24251bc05000056_005 | yes |
Physical and functional crosstalk between Fanconi anemia core components and the GINS replication complex. Fanconi anemia (FA) is an inherited disease characterized by bone marrow failure, increased cancer risk and hypersensitivity to DNA cross-linking agents, implying a role for this pathway in the maintenance of geno... | Is hypersensitivity to DNA crosslinking agents a hallmark of Fanconi anemia? | 54ecb66d445c3b5a5f000002_012 | yes |
Serum endostatin levels are elevated in patients with soft tissue sarcoma. BACKGROUND: Solid tumors are angiogenesis dependent, and elevated levels of proangiogenic cytokines have been reported in a variety of histologies. Endostatin is an antiangiogenic fragment of the basement membrane protein, collagen XVIII. Becaus... | Is endostatin a proangiogenic factor? | 53124e84e3eabad02100000c_008 | no |
Irritable bowel syndrome and chronic constipation in patients with endometriosis. AIM: The aim of this study was to evaluate how many patients with endometriosis have concomitant irritable bowel syndrome (IBS) and/or constipation according to the Rome III criteria. Furthermore, the value of an additional gastroenterolo... | Is irritable bowel syndrome more common in women with endometriosis? | 54f08d4a94afd61504000016_015 | yes |
The regulation of SERCA-type pumps by phospholamban and sarcolipin. Both sarcolipin (SLN) and phospholamban (PLN) lower the apparent affinity of either SERCA1a or SERCA2a for Ca(2+). Since SLN and PLN are coexpressed in the heart, interactions among these three proteins were investigated. When SERCA1a or SERCA2a were c... | Does Serca2a bind PLN in the heart? | 51680b05298dcd4e51000064_010 | yes |
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