reference
stringlengths
7
774
aptamer_chemistry
stringclasses
21 values
aptamer_name
stringlengths
1
164
target_name
stringlengths
2
1.2k
aptamer_sequence
stringlengths
2
380
origin
stringclasses
6 values
target_chemistry
stringclasses
11 values
external_id
stringclasses
509 values
target_sequence
stringclasses
357 values
new_affinity
stringlengths
3
193
Yu, H., Canoura, J., Guntupalli, B., Lou, X., & Xiao, Y. (2017). A cooperative-binding split aptamer assay for rapid, specific and ultra-sensitive fluorescence detection of cocaine in saliva. Chemical Science, 8(1), 131–141. doi:10.1039/c6sc01833eMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
CBSA-5335 LF (ID# 8119)
Cocaine
CTCCTTCAACGAAGTGGGTCTCCTTCAACGAAGTGGGTCTC
https://www.aptagen.com/apta-index/
Small Organic
null
null
36 nM
Yang, M., Peng, Z., Ning, Y., Chen, Y., Zhou, Q., Deng, L., 2013. Highly specific and cost-efficient detection of salmonella paratyphi a combining aptamers with single-walled carbon nanotubes. Sensors 13, 6865–6881.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Apt22 (ID# 8212)
Salmonella Paratyphi A
ATGGACGAATATCGTCTCCCAGTGAATTCAGTCGGACAGCG
https://www.aptagen.com/apta-index/
Cells
null
null
47 nM
Gebhardt, K., et al. "RNA Aptamers to S-Adenosylhomocysteine: Kinetic Properties, Divalent Cation Dependency, and Comparison with Anti-S-adenosylhomocysteine Antibody." Biochemistry, 39 (2000): 7255-7265.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
S-adenosyl homocysteine (CTH-5) (ID# 7514)
S-adenosyl homocysteine
GGGCGGAUGAGACGCUUGGCGUGUGCUGUGGAGAGUCAUCCG
https://www.aptagen.com/apta-index/
Small Organic
null
null
0.1 nM
X Tan et al. Molecular beacon aptamers for direct and universal quantitation of recombinant proteins from cell lysates. Anal. Chem. [published online ahead of print August 23, 2012]. doi: 10.1021/ac301764qMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
HMBA (aptabeacon) (ID# 7716)
6X His-tag
ACAGGTTGGTCTGGTTGGGTTTGGCTCCTGTGTACGCAACCTGCG
https://www.aptagen.com/apta-index/
Protein
null
null
Not Mentioned in Database
L. Zhat et al. An RNA aptamer-based microcantilever sensor to detect the inflammatory marker, mouse lipocalin-2. Anal. Chem. 84(2012):8763-8770.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
Mouse Lipocalin-2 (mLcn2) (Oligo 569) (ID# 7744)
Mouse Lipocalin-2 (mLcn2)
CCUCCGGCUCAUACCUUUUCGAAGACAAGCUUCGACAGGAGG
https://www.aptagen.com/apta-index/
Protein
null
null
340 nM
Han, S. R. and Lee, S. "In Vitro Selection of RNA Aptamer Specific to Salmonella Typhimurium." Journal of Microbiology and Biotechnology, 23.6(2013): 878-84.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
Salmonella Typhimurium OmpC Protein (T-2) (ID# 7876)
S. Typhimurium OmpC Protein
UAGUGUGAGAGCCGUGAGUGAAAGGCCGCGACAAAGAUCGGA
https://www.aptagen.com/apta-index/
Protein
null
null
20 nM
Wang H, Li X, Lai LA, Brentnall TA, Dawson DW, Kelly KA, Chen R, Pan S. X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma. Biochimie. 2021 Feb;181:25-33. doi: 10.1016/j.biochi.2020.11.018. Epub 2020 Nov 23. PMID: 33242496; PMCID: PMC7863625.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
XA-A9 (ID# 8093)
Thy-1 membrane glycoprotein
TTGCCCACAGATCTGTGGAAGCCGAACCGCGTGCTAGTCGTG
https://www.aptagen.com/apta-index/
Protein
null
null
15 nM
Wang H, Li X, Lai LA, Brentnall TA, Dawson DW, Kelly KA, Chen R, Pan S. X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma. Biochimie. 2021 Feb;181:25-33. doi: 10.1016/j.biochi.2020.11.018. Epub 2020 Nov 23. PMID: 33242496; PMCID: PMC7863625.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
XA-B216 (ID# 8094)
Thy-1 membrane glycoprotein
TTGCCCACCTCCCTGTGCGGGCCACAGAGCAGCAGTGTCGTG
https://www.aptagen.com/apta-index/
Protein
null
null
36 nM
Wang H, Li X, Lai LA, Brentnall TA, Dawson DW, Kelly KA, Chen R, Pan S. X-aptamers targeting Thy-1 membrane glycoprotein in pancreatic ductal adenocarcinoma. Biochimie. 2021 Feb;181:25-33. doi: 10.1016/j.biochi.2020.11.018. Epub 2020 Nov 23. PMID: 33242496; PMCID: PMC7863625.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
XA-B217 (ID# 8095)
Thy-1 membrane glycoprotein
TTGCCCACCGTACTGTGCAGGTCGAACTACAGGCACGTCGTG
https://www.aptagen.com/apta-index/
Protein
null
null
2 nM
Song Z, Mao J, Barrero RA, Wang P, Zhang F, Wang T. Development of a CD63 Aptamer for Efficient Cancer Immunochemistry and Immunoaffinity-Based Exosome Isolation. Molecules. 2020 Nov 27;25(23):5585. doi: 10.3390/molecules25235585. PMID: 33261145; PMCID: PMC7730289.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
CD63-1 (ID# 8097)
CD63
TAACACGACAGACGTTCGGAGGTCGAACCCTGACAGCGTGGG
https://www.aptagen.com/apta-index/
Protein
null
null
38.71 nM
Niu, C., Ding, Y., Zhang, C., & Liu, J. (2022). Comparing two cortisol aptamers for label-free fluorescent and colorimetric biosensors. Sensors & Diagnostics, 1(3), 541–549. https://doi.org/10.1039/d2sd00042cMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
CSS.1 (ID# 8201)
Cortisol
GACGACGCCCGCATGTTCCATGGATAGTCTTGACTAGTCGTC
https://www.aptagen.com/apta-index/
Small Organic
null
null
245 nM
Chen and Gold. "Selection of High-Affinity RNA Ligands to Reverse Transcriptase: Inhibition of cDNA Synthesis and RNase H Activity." Journal of Biochemistry, 33(1994): 8746-8756.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
Avian Myeloblastosis Virus (a.1.1) (ID# 7574)
Avian Myeloblastosis Virus (AMV) RT
CGUCCCGUGCGCAAAAGUUCUUAGCGCUAGCAGUCCUAGUUGC
https://www.aptagen.com/apta-index/
Protein
null
null
0.5 nM
Hong-Ru Liang, Gui-Qiu Hu, Xiang-Hong Xue, Lu Li, Xue-Xing Zheng,Yu-Wei Gao, Song-Tao Yang, Xian-Zhu Xia, "Selection of an aptamer against rabies virus: A new class of molecules with antiviral activity". Virus Research 184 (2014) 7-13.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
GE54 (ID# 7909)
Rabies Virus glycoprotein(RABV)
TATTTTTATATTTGTTTGACAGTCGCTTGCTTGTGTAGGCGTT
https://www.aptagen.com/apta-index/
Protein
null
null
307 nM
Yang, Z. et al. Community Sewage Sensors towards Evaluation of Drug Use Trends: Detection of Cocaine in Wastewater with DNA-Directed Immobilization Aptamer Sensors. Sci. Rep. 6, 21024; doi: 10.1038/srep21024 (2016).Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Cocaine Aptamer (ID# 7966)
Cocaine
GACAAGGATAAATCCTTCAATGAAGTGGGTCACTCATCTGTGA
https://www.aptagen.com/apta-index/
Small Organic
null
null
Not Mentioned in Database
Zhang, L., Wang, S., Yang, Z., Hoshika, S., Xie, S., Li, J., …Tan, W. (2019). An Aptamer‐Nanotrain Assembled from 6‐Letter DNA Delivers Doxorubicin Selectively to Liver Cancer Cells. Angewandte Chemie. doi:10.1002/ange.201909691Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
LZH5B (ID# 8024)
HepG2 Liver Cancer Cells
GTGACGCAGCAGCTACTTGGGCCCTGGTTTCTGTGCTGGACAC
https://www.aptagen.com/apta-index/
Cells
null
null
12 nM
Kwon, J., Narayan, C., Kim, C., Han, M. J., Kim, M., & Jang, S. K. (2019). Development of a Subtype-Specific Diagnostic System for Influenza Virus H3N2 Using a Novel Virus-Based Systematic Evolution of Ligands by Exponential Enrichment (Viro-SELEX). Journal of Biomedical Nanotechnology, 15(7), 1609–1621. https://doi.org/10.1166/jbn.2019.2789Gold L, Ayers D, Bertino J, Bock C, Bock A, Brody EN, et al. (2010) Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery. PLoS ONE 5(12): e15004. https://doi.org/10.1371/journal.pone.0015004Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Aptamer A14 (ID# 8033)
HA protein of CJ01 H1N1 Influenza Virus
CCTGCCTTTGGCAGCCGGGCGAAGGCAACCCGACACCGACAGC
https://www.aptagen.com/apta-index/
Protein
null
null
2.98 nM
Famulok, M., " Molecular Recognition of Amino Acids by RNA-Aptamers: An L-Citrulline Binding RNA Motif and its Evolution into an L-Arginine Binder." Journal of the American Chemical Society, 116 (1994): 1698-1706.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
L-Citrulline (44Cit11) (ID# 7517)
L-Citrulline
GACGAGAAGGAGUGCUGGUUAUACUAGCGGUUAGGUCACUCGUC
https://www.aptagen.com/apta-index/
Small Organic
null
null
68 µM
M S Wang et al. "C-reactive protein (CRP) aptamer binds to monomeric but not pentameric form of CRP." Analytical and Bioanalytical Chemistry, 401(2011): 1309-1318. M S Wang and S M Reed. Direct visualization of electrophoretic mobility shift assays using nanoparticle-aptamer conjugates. Electrophoresis. 33(2012): 348-351.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
C-Reactive Protein Monomer (ID# 7565)
Monomeric C-Reactive Protein (CRP)
GCCUGUAAGGUGGUCGGUGUGGCGAGUGUGUUAGGAGAGAUUGC
https://www.aptagen.com/apta-index/
Protein
null
null
187.7 nM
Famulok, M., " Molecular Recognition of Amino Acids by RNA-Aptamers: An L-Citrulline Binding RNA Motif and its Evolution into an L-Arginine Binder." Journal of the American Chemical Society, 116 (1994): 1698-1706.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
L-Arginine(44Arg11) (ID# 7583)
L-Arginine
GACGAGAAGGAGCGCUGGUUCUACUAGCAGGUAGGUCACUCGUC
https://www.aptagen.com/apta-index/
Small Organic
null
null
60 nM
Levesque et al. "In vitro selection and characterization of RNA aptamers binding thyroxine hormone." Biochemical Journal, 403(2007): 129-138.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
Thyroxine (ApT4-A’) (ID# 7585)
Thyroxine
GGUGGAGGGGGACGUGCUGCAUCCGCAGUGCGUCUUGGGUUGUG
https://www.aptagen.com/apta-index/
Small Organic
null
null
50 µM
A Bini, M Mascini, et al. Development of an optical RNA-based aptasensor for C-reactive protein. Anal. Bioanal. Chem. 390(2008): 1077-1088Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
C-Reactive Protein (ID# 7819)
C-Reactive Protein (CRP)
GCCUGUAAGGUGGUCGGUGUGGCGAGUGUGUUAGGAGAGAUUGC
https://www.aptagen.com/apta-index/
Protein
null
null
125 nM
Huang, M., Song, J., Huang, P., Chen, X., Wang, W., Zhu, Z., Song, Y., & Yang, C. (2019). Molecular Crowding Evolution for Enabling Discovery of Enthalpy-Driven Aptamers for Robust Biomedical Applications. Analytical Chemistry, 91(16), 10879–10886. https://doi.org/10.1021/acs.analchem.9b02697Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Enthalpy Driven Aptamer SYL-H2C (ID# 8044)
EpCAM
GAGCTCGGGGTTTGGGGGTTCGGGGTCGGTTCGGTTTCTT
https://www.aptagen.com/apta-index/
Protein
null
null
34.7 nM
Yang KA, Barbu M, Halim M, et al. Recognition and sensing of low-epitope targets via ternary complexes with oligonucleotides and synthetic receptors. Nat Chem. 2014;6(11):1003-1008. doi:10.1038/nchem.2058Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Glucose-bisboronic acid aptamer-sensor (ID# 8045)
Glucose
CTCTCGGGACGACAGCCGAGTTGATTCAACAGCCGAGTCGTCCC
https://www.aptagen.com/apta-index/
Small Organic
null
null
5 nM
Xiong, H., Yan, J., Cai, S., He, Q., Peng, D., Liu, Z., & Liu, Y. (2019). Cancer protein biomarker discovery based on nucleic acid aptamers. International Journal of Biological Macromolecules. doi:10.1016/j.ijbiomac.2019.03.165Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
S3 (ID# 8057)
CD109
TCTGAGAATAGTGGTTTGCTGTATGGTGGGCGTTGAAAGAGGGG
https://www.aptagen.com/apta-index/
Protein
null
null
10.5332 - 13.3326 nM
Qiao, N., Li, J., Wu, X., Diao, D., Zhao, J., Li, J., … Lou, X. (2019). Speeding up in vitro Discovery of Structure-Switching Aptamers via Magnetic Cross-Linking Precipitation. Analytical Chemistry. doi:10.1021/acs.analchem.9b00081Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Tb-L8 (ID# 8062)
Thrombin
GGTGTGGGCGACATGGGGGTTGGTGGTGTAGGAGCGCCAT
https://www.aptagen.com/apta-index/
Protein
null
null
33 nM
Lin et al. "Peptide conjugation to an in vitro-selected DNA ligand improves enzyme inhibition." PNAS, 92(1995): 11044-11048.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Human Neutrophil Elastase (DNA I) (ID# 7576)
Human Neutrophil Elastase (HNE)
TAGCGATACTGCGTGGGTTGGGGCGGGTAGGGCCAGCAGTCTCGT
https://www.aptagen.com/apta-index/
Protein
null
null
17 nM
Aptamer Selection Reference: Wiegand, T.W., et al. "High-Affinity Oligonucleotide Ligands to Human IgE Inhibit Binding to FCE Receptor I." Journal of Immunology, 157 (1996): 221-230 Liss, M., et al. "An Aptamer-Based Quartz Crystal Protein Biosensor." Anal. Chem.,74 (2002): 4488-4495.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Anti-IgE Aptamer, D 17.4 ext (ID# 7666)
IgE (human)
GCGCGGGGCACGTTTATCCGTCCCTCCTAGTGGCGTGCCCCGCGC
https://www.aptagen.com/apta-index/
Protein
null
null
3.6 nM
Kim HR, Song MY, Chan Kim B. Rapid isolation of bacteria-specific aptamers with a non-SELEX-based method. Analytical Biochemistry. 2020 Feb;591:113542. DOI: 10.1016/j.ab.2019.113542.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
20-10 (ID# 8013)
E. coli
TATGGCGTGGCAAGCTTGGCCCGCTTCTCAAGCATGGTTATCTAC
https://www.aptagen.com/apta-index/
Cells
null
null
10.1 nM
Lee, K.H., Zeng, H. A general double library SELEX strategy for aptamer selection using unmodified nonimmobilized targets. Anal Bioanal Chem 409, 5081–5089 (2017).Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
VA 6 (ID# 8014)
VEGF165
CGACCTTAGCCTATGTTTTCTCTACCGGCTATGTTACGCGGGTCG
https://www.aptagen.com/apta-index/
Protein
null
null
71 nM
Kim HR, Song MY, Chan Kim B. Rapid isolation of bacteria-specific aptamers with a non-SELEX-based method. Analytical Biochemistry. 2020 Feb;591:113542. DOI: 10.1016/j.ab.2019.113542.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
20-7 (ID# 8015)
E. coli
CGCAATACCAAAGTGGCGAGAGCGCTGTCTTGAGTGAGTGGTTGG
https://www.aptagen.com/apta-index/
Cells
null
null
8.0 nM
Kim HR, Song MY, Chan Kim B. Rapid isolation of bacteria-specific aptamers with a non-SELEX-based method. Analytical Biochemistry. 2020 Feb;591:113542. DOI: 10.1016/j.ab.2019.113542.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
20-5 (ID# 8016)
E. coli
ATTTCGCCCCCGTGTTCCGACTGGTATCTTCACGTCTTCGAGTGT
https://www.aptagen.com/apta-index/
Cells
null
null
3.9 nM
Trachman, R. J., Autour, A., Jeng, S. C. Y., Abdolahzadeh, A., Andreoni, A., Cojocaru, R., … Ferré-D’Amaré, A. R. (2019). Structure and functional reselection of the Mango-III fluorogenic RNA aptamer. Nature Chemical Biology, 15(5), 472–479. doi:10.1038/s41589-019-0267-9Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
Mango III A10U (ID# 8021)
Thiazole Orange - Biotin (TO1-Biotin)
GGCACGUACGAAGGAAGGUUUGGUAUGUGGUAUAUUCGUACGUGC
https://www.aptagen.com/apta-index/
Small Organic
null
null
1.7 nM
Kwon, J., Narayan, C., Kim, C., Han, M. J., Kim, M., & Jang, S. K. (2019). Development of a Subtype-Specific Diagnostic System for Influenza Virus H3N2 Using a Novel Virus-Based Systematic Evolution of Ligands by Exponential Enrichment (Viro-SELEX). Journal of Biomedical Nanotechnology, 15(7), 1609–1621. https://doi.org/10.1166/jbn.2019.2789 Gold L, Ayers D, Bertino J, Bock C, Bock A, Brody EN, et al. (2010) Aptamer-Based Multiplexed Proteomic Technology for Biomarker Discovery. PLoS ONE 5(12): e15004. https://doi.org/10.1371/journal.pone.0015004Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Aptamer A1 (ID# 8032)
HA protein of CJ01 H1N1 Influenza Virus
CCTGCCTTTGGAACCGACCGCCAGGCCGAGGAAAGGCACCGACAGC
https://www.aptagen.com/apta-index/
Protein
null
null
3.36 nM
Yu, H., Luo, Y., Alkhamis, O., Canoura, J., Yu, B., & Xiao, Y. (2021). Isolation of Natural DNA Aptamers for Challenging Small-Molecule Targets, Cannabinoids. Analytical chemistry, 93(6), 3172–3180. https://doi.org/10.1021/acs.analchem.0c04592Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
XA1 (ID# 8158)
XLR-11
CTTACGACTGTGGTCGGGTGGTGGGCCTCTAGAGGGGTGTCGTAAG
https://www.aptagen.com/apta-index/
Small Organic
null
null
310 nM
Haixiang Yu, Weijuan Yang, Obtin Alkhamis, Juan Canoura, Kyung-Ae Yang, Yi Xiao, In vitro isolation of small-molecule-binding aptamers with intrinsic dye-displacement functionality, Nucleic Acids Research, Volume 46, Issue 8, 4 May 2018, Page e43, https://doi.org/10.1093/nar/gky026Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Aptamer MA (ID# 8176)
methylenedioxypyrovalerone (MDPV)
CTTACGACTCAGGCATTTTGCCGGGTAACGAAGTTACTGTCGTAAG
https://www.aptagen.com/apta-index/
Small Organic
null
null
7 nM
Sun, M., Liu, S., Wei, X., Wan, S., Huang, M., Song, T., Lu, Y., Weng, X., Lin, Z., Chen, H., Song, Y., & Yang, C. (2021). Aptamer Blocking Strategy Inhibits SARS-CoV-2 Virus Infection. Angewandte Chemie (International ed. in English), 60(18), 10266–10272. https://doi.org/10.1002/anie.202100225Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
CoV2-6C3 (ID# 8195)
SARS-CoV-2 Spike Protein RBD
CGCAGCACCCAAGAACAAGGACTGCTTAGGATTGCGATAGGTTCGG
https://www.aptagen.com/apta-index/
Protein
null
null
44.78 nM
S.H. Ohk et al. Antibody-aptamer functionalized fibre-optic biosensor for specific detection of Listeria monocytogenes from food. J. Appl. Microbiol. 109(2010): 808-817.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Internalin A of Listeria monocytogenes (ID# 7769)
Internalin A (InlA)
ATCCATGGGGCGGAGATGAGGGGGAGGAGGGCGGGTACCCGGTTGAT
https://www.aptagen.com/apta-index/
Protein
null
null
Not Mentioned in Database
Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
S21 (ID# 8065)
Cas9
GAGGCTCTCACATCGCGCCTTTCCCCAGCTTTCGGTGTGAGAGCCTC
https://www.aptagen.com/apta-index/
Protein
null
null
0.63 nM
Gao T , Ding P , Li W , Wang Z , Lin Q , Pei R . Isolation of DNA aptamers targeting N-cadherin and high-efficiency capture of circulating tumor cells by using dual aptamers. Nanoscale. 2020 Nov 19;12(44):22574-22585. doi: 10.1039/d0nr06180h. PMID: 33174555.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
NC3S (ID# 8079)
N‑Cadherin
TTGCACTATGTTTTAGCTAGGGTTCCCTCCGGAGATAGTAAGTGCAA
https://www.aptagen.com/apta-index/
Protein
null
null
20.08 ± 0.72 nM
Yu XX, Ge KL, Liu N, Zhang JY, Xue ML, Ge YL. Selection and Characterization of a Novel DNA Aptamer, Apt-07S Specific to Hepatocellular Carcinoma Cells. Drug Des Devel Ther. 2020 Apr 20;14:1535-1545. doi: 10.2147/DDDT.S244149. PMID: 32368012; PMCID: PMC7182459.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Apt-07S (ID# 8108)
HepG2 (Kd = 194.7nM) and SMMC-7721 (Kd = 224.2nM)
GTACTGTCAATTGGAAGTGGTGTTACGTTGTGTAGTCAAATCAGTGC
https://www.aptagen.com/apta-index/
Cells
null
null
194.7 and 224.2 nM
Yu, H., Luo, Y., Alkhamis, O., Canoura, J., Yu, B., & Xiao, Y. (2021). Isolation of Natural DNA Aptamers for Challenging Small-Molecule Targets, Cannabinoids. Analytical chemistry, 93(6), 3172–3180. https://doi.org/10.1021/acs.analchem.0c04592Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
THC1.2 (ID# 8156)
THC
CTTACGACCCAGGGGGGTGGACAGGCGGGGGTTAGGGGGGTCGTAAG
https://www.aptagen.com/apta-index/
Small Organic
null
null
40 nM
Lee, Seong-Wook and Sullenger, Bruce. "Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies." Nature Biotechnology, 15 (1997): 41-45.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
2'-NH2-RNA
Acetylcholine Receptor Antibody (mAB198) (SE RNA VII) (ID# 7482)
Acetylcholine Receptor Antibody (mAB198)
UGGGCCGGAGGUUAGCUUGCCCAUGGCAAGCAGGGCGCCACGGACCCA
https://www.aptagen.com/apta-index/
Protein
null
null
60 nM
Lee and Sullenger. "Isolation of a nuclease-resistant decoy RNA that can protect human acetylcholine receptors from myasthenic antibodies." Nature Biotechnology, 15(1997):Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
2'-NH2-RNA
Anti-acetylcholine Autoantibodies (SE RNA) (ID# 7538)
Anti-acetylcholine Autoantibodies
UGGGCCGGAGGUUAGCUUGCCCAUGGCAAGCAGGGCGCCACGGACCCA
https://www.aptagen.com/apta-index/
Protein
null
null
60 nM
Tang et al. "Selection of Aptamers for Molecular Recognition and Characterization of Cancer Cells." Analytical Chemistry, 79(2007): 4900-4907.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Ramos Cells (TD05) (ID# 7664)
Ramos Cells (B-cell lymphoma cell line)
AACACCGTGGAGGATAGTTCGGTGGCTGTTCAGGGTCTCCTCCCGGTG
https://www.aptagen.com/apta-index/
Cells
null
null
74.7 nM
Lin et al. "Recognition Imaging of Acetylated Chromatin Using a DNA Aptamer." Biophysical Journal, 97(2009): 1804-07.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Histone (H4K16Ac) (ID# 7722)
H4K16Ac
AGACGTAAGTTAATTGGACTTGGTCGTGTGCGGCACAGCGATTGAAAT
https://www.aptagen.com/apta-index/
Peptide
null
null
47 nM
Meng, Hsein-Wei, and John Pagano. "Discovering Aptamers by Cell-SELEX against Human Soluble Growth Factors Ectopically Expressed on Yeast Cell Surface." Plos-One 9.3 (2014): 1-12. Print.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
hVap1_Stem (ID# 7922)
VEGF
TCTAGCCCACTGCATAGAGGTAGCCACGTATGTTCGTGGCTACCGGTG
https://www.aptagen.com/apta-index/
Protein
null
null
5.6 nM
Yang K, Pei R, Stefanovic D, Stojanovic M.N. (2011) Optimizing Cross-reactivity with Evolutionary Search for Sensors. J. Am. Chem. Soc.134:1642-1647.
DNA
Beta-Estradiol Aptamer (BES.1) (ID# 7961)
Beta-Estradiol (Estrogen)
GGCTCTCGGGACGACATGGATTTTCCATCAACGAAGTGCGTCCGTCCC
https://www.aptagen.com/apta-index/
Small Organic
null
null
6 µM
Selection of DNA Aptamers against Epithelial Cell Adhesion Molecule for Cancer Cell Imaging and Circulating Tumor Cell Capture Yanling Song, Zhi Zhu, Yuan An, Weiting Zhang, Huimin Zhang, Dan Liu, Chundong Yu, Wei Duan, and Chaoyong James Yang Analytical Chemistry 2013 85 (8), 4141-4149 DOI: 10.1021/ac400366bMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Epithelial Cell Adhesion Molecule (EpCAM) SYL3C (ID# 7980)
Cancer Cells
CACTACAGAGGTTGCGTCTGTCCCACGTTGTCATGGGGGGTTGGCCTG
https://www.aptagen.com/apta-index/
Cells
null
null
38 nM
Boyacioglu, O., Stuart, C. H., Kulik, G., & Gmeiner, W. H. (2013). Dimeric DNA Aptamer Complexes for High-capacity–targeted Drug Delivery Using pH-sensitive Covalent Linkages. Molecular Therapy - Nucleic Acids, 2, e107. doi:10.1038/mtna.2013.37Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
PSMA Aptamer (SZTI01) (ID# 8017)
Prostate-specific membrane antigen (PSMA)
GCGTTTTCGCTTTTGCGTTTTGGGTCATCTGCTTACGATAGCAATGCT
https://www.aptagen.com/apta-index/
Protein
null
null
Unknown
Mayer, Gunter, et al. “Fluorescence-activated cell sorting for aptamer SELEX with cell mixtures.” Nature Protocols 5, (2010): 1993-2004.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
C10 (ID# 8026)
CD19+
CCCGGGTGTGGTGGGTGGGCAGGGGGGTTAGCATCTCACCAGCTCCGCA
https://www.aptagen.com/apta-index/
Protein
null
null
49.6 nM
Aptamer Binding Assay for the E Antigen of Hepatitis B Using Modified Aptamers with G-Quadruplex StructuresYanming Liu, Connie Le, D. Lorne Tyrrell, X. Chris Le, and Xing-Fang LiAnalytical Chemistry 2020 92 (9), 6495-6501DOI: 10.1021/acs.analchem.9b05740Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
EAg3-Py (ID# 8034)
Hepatitis B - E Antigen (HBeAg)
TTTTTTTTGGGCGAAGACCGGGACGGGAGGAAAGAGATGTTTGGTTTT
https://www.aptagen.com/apta-index/
Protein
null
null
0.4 nM
Vianini et al. "In vitro selection of DNA aptamers that bind L-tyrosinamide." Bioorganic & Medicinal Chemistry, 9 (2001): 2543-2548.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
L-Tyrosinamide (pe35) (ID# 7519)
L-Tyrosinamide
AATTCGCTAGCTGGAGCTTGGATTGATGTGGTGTGTGAGTGCGGTGCCC
https://www.aptagen.com/apta-index/
Small Organic
null
null
45 µM
Lauhon and Szostak. "RNA Aptamers That Bind Flavin and Nicotinamide Redox Cofactors." Journal of the American Chemical Society, 117(1994): 1246-1257.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
NAD (ID# 7552)
NAD
GGAACCCAACUAGGCGUUUGAGGGGAUUCGGCCACGGUAACAACCCCUC
https://www.aptagen.com/apta-index/
Small Organic
null
null
2.5 nM
Lauhon and Szostak. "RNA Aptamers That Bind Flavin and Nicotinamide Redox Cofactors." Journal of the American Chemical Society, 117(1994): 1246-1257.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
NADH (ID# 7667)
NADH
GGAACCCAACUAGGCGUUUGAGGGGAUUCGGCCACGGUAACAACCCCUC
https://www.aptagen.com/apta-index/
Small Organic
null
null
37 nM
Fu et al. "An ultrasensitive peroxidase DNAzyme-associated aptasensor that utilizes a target-triggered enzymatic signal amplification strategy." Chemical Communications, 47(2011): 9876-9878.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
DNA Blocker (Part of Lysozyme Aptasensor) (ID# 7703)
Lysozyme
ATCTACGAATTCATCAGGGCTAAAGAGTGCAGAGTTACTTAGCCCGTGA
https://www.aptagen.com/apta-index/
Other
null
null
Not Mentioned in Database
YJ Lee et al. An RNA aptamer that binds carcinoembryonic antigen inhibits hepatic metastasis of colon cancer cells in mice. Gastroenterology 143(2012): 155-165.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
Chimeric
Carcinoembryonic Antigen Aptamer (YJ-1) (ID# 7712)
Carcinoembryonic Antigen (CEA)
GCGGAAGCGUGCUGGGCUAGAAUAAUAAUAAGAAAACCAGUACUUUCGU
https://www.aptagen.com/apta-index/
Protein
null
null
0.77 nM
Hicke, Brain, et al. "DNA Aptamers Block L-Selectin Function In Vivo Inhibition of Human Lymphocyte Traf?cking in SCID Mic." Journal of Clinical Investigation, 98 (1996): 2688-2692Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
L-Selectin (LD201t1) (ID# 7772)
L-Selectin binding to sialyl Lewis X
TAGCCAAGGTAACCAGTACAAGGTGCTAAACGTAATGGCTTCGGCTTAC
https://www.aptagen.com/apta-index/
Protein
null
null
Not Mentioned in Database
Chang EK, Eckert MA, Ali MM, Riazifar H, Pone EJ, Liu L, et al. (2015) Facile Supermolecular Aptamer Inhibitors of L-Selectin. PLoS ONE 10(3): e0123034. doi:10.1371/journal.pone.0123034Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
L-Selectin Multivalent Aptamer (ID# 7951)
L-Selectin
TAGCCAAGGTAACCAGTACAAGGTGCTAAACGTAATGGCTTCGGCTTAC
https://www.aptagen.com/apta-index/
Protein
null
null
Not Mentioned in Database
Isolation and Identification of the DNA Aptamer Target to AcetamipridJiang He, Yuan Liu, Mingtao Fan, and Xianjin LiuJournal of Agricultural and Food Chemistry 2011 59 (5), 1582-1586DOI: 10.1021/jf104189gMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Acetamiprid Binding Aptamer (S18) (ID# 8001)
Acetamiprid
TGTAATTTGTCTGCAGCGGTTCTTGATCGCTGACACCATATTATGAAGA
https://www.aptagen.com/apta-index/
Small Organic
null
null
4.98 µM
Leva, S., et al. "GnRH Binding RNA and DNA Spiegelmers: A Novel Approach toward GnRH Antagonism." Chemistry and Biology, 9 (2002): 351-359.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
L-RNA
Gonadotropin-releasing hormone 1 (A10) (ID# 7492)
Gonadoliberin/Gonadotropin-releasing hormone 1 (GnRH)
CGGCCGAUAGAAAGACUACUUGAGCCCUUAAAUGAGGUUAUGUGCGGCCG
https://www.aptagen.com/apta-index/
Peptide
null
null
190 nM
Cerchia, Laura, et al. "Neutralizing Aptamers from Whole-Cell SELEX Inhibit the RET Receptor Tyrosine Kinase." PLoS Biology, 3 (2004): e123Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
2'-F-RNA
Receptor Tyrosine Kinase (RET) Mutant (D4) (ID# 7500)
Receptor Tyrosine Kinase (RET) Mutant
GCGCGGGAAUAGUAUGGAAGGAUACGUAUACCGUGCAAUCCAGGGCAACG
https://www.aptagen.com/apta-index/
Protein
null
null
35 nM
Burke et al. "RNA aptamers to the peptidyl transferase inhibitor chloramphenicol." Chemistry & Biology, 4(1997): 833-843.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
Chloramphenicol (Cm1) (ID# 7556)
Chloramphenicol
GGGAUCACAGUGAAAAAAGACGUGUGAAUGUCACACUGAAAAAAGAUCCC
https://www.aptagen.com/apta-index/
Small Organic
null
null
110 nM
Yu et al. "Aptamers can Discriminate Alkaline Proteins with High Specificity." Chem. Biochem. , 12(2011): 2659-2666.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Histone H4 N-terminal tail (4.33) (ID# 7721)
H4 N-terminal tail
TGGTGGGGTTCCCGGGAGGGCGGCTACGGGTTCCGTAATCAGATTTGTGT
https://www.aptagen.com/apta-index/
Protein
null
null
1.3 nM
Z Kiani et al. In vitro selection and characterization of deoxyribonucleic acid aptamers for digoxin. Analytica Chimica Acta 748(2012): 67-72.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Digoxin (Truncated D1) (ID# 7770)
Digoxin
AGCGAGGGCGGTGTCCAACAGCGGTTTTTTCACGAGGAGGTTGGCGGTGG
https://www.aptagen.com/apta-index/
Protein
null
null
0.05 nM
Li et al. "Characterization of DNA aptamers generated against the soft-shelled turtle iridovirus with antiviral effects." BMC Veterinary Research, 11 (2015): Article number 245.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
QA-36 (ID# 8089)
Soft-Shelled Turtle Iridovirus (STIV)
TGTGCGGGGGAGGGGAGTGGCGCTGTTGGTGCGGGTATAGCGCGTGGTGT
https://www.aptagen.com/apta-index/
Other
null
null
53.8 nM
Dunn MR, McCloskey CM, Buckley P, Rhea K, Chaput JC. Generating Biologically Stable TNA Aptamers that Function with High Affinity and Thermal Stability. J Am Chem Soc. 2020 Apr 29;142(17):7721-7724. doi: 10.1021/jacs.0c00641. Epub 2020 Apr 20. PMID: 32298104.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
HIV-RT 3.17 (ID# 8103)
HIV reverse transcriptase (HIV RT)
TTATGTAGCATTTATGAAATTTTTAAATCAATTTACTATTGGTGGTATCC
https://www.aptagen.com/apta-index/
Cells
null
null
0.38 nM
Yu, F., Li, H., Sun, W., Xu, D. and He, F., 2019. Rapid selection of aptamers based on protein microarray. RSC advances, 9(17), pp.9762-9768.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
YFL-6 (ID# 8180)
Lactoferrin
AGGCAGGACACCGTAACCGGTGCATCTATGGCTACTAGCTCTTCCTGCCT
https://www.aptagen.com/apta-index/
Protein
null
null
4.97 nM
Pereira, A. C., Pina, A. F., Sousa, D., Ferreira, D., Santos-Pereira, C., Rodrigues, J. L., Melo, L. D. R., Sales, G., Sousa, S. F., & Rodrigues, L. R. (2022). Identification of novel aptamers targeting cathepsin B-overexpressing prostate cancer cells. Molecular Systems Design & Engineering, 7(6), 637–650. https://doi.org/10.1039/d2me00022aMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Apt08rc (ID# 8207)
Cathepsin B
GGGCAGGCAACCTCCCACTATTGAAGACACTACCACCACCACTGCACACA
https://www.aptagen.com/apta-index/
Protein
null
null
10.1-10.7 nM
Deniz Yılmaz, Tuğdem Muslu, Ayhan Parlar, Hasan Kurt, Meral Yüce,SELEX against whole-cell bacteria resulted in lipopolysaccharide binding aptamers, Journal of Biotechnology, Volume 354, 2022, Pages 10-20, ISSN 0168-1656.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
EC1 (ID# 8208)
Escherichia Coli
AATGATGACATTCCGAGGTACCCAGAGTGCGATACTAACCGGCCTGCTTG
https://www.aptagen.com/apta-index/
Cells
null
null
1.165 nM
Deniz Yılmaz, Tuğdem Muslu, Ayhan Parlar, Hasan Kurt, Meral Yüce, SELEX against whole-cell bacteria resulted in lipopolysaccharide binding aptamers, Journal of Biotechnology, Volume 354, 2022, Pages 10-20, ISSN 0168-1656.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
LM3 (ID# 8209)
Listeria monocytogenes
CCGTCCCGGTAGTCTGAGCTTACAATGTCTGATTGGAAATGCACACCAAG
https://www.aptagen.com/apta-index/
Cells
null
null
8.89 nM
Heike, S., et al. "Aptamers that bind to the antibiotic moenomycin A." Bioorganic & Medicinal Chemistry, 9 (2001): 2557-2563.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
2'-NH2-RNA
Moenomycin A (C2) (ID# 7494)
Moenomycin A
GGAGGUCGACCUCGCGCGAGGAGGGUGGAGGGUCGUAGAGCGCGUAGGAGG
https://www.aptagen.com/apta-index/
Small Organic
null
null
350 nM
Bridonneau, P., et al. "High-Affinity Aptamers Selectively Inhibit Human Nonpancreatic Secretory Phospholipase A2 (hnps-PLA2)." Journal of Medicinal Chemistry, 41(1998): 778-786.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
2'-NH2-RNA
Human Nonpancreatic Secretory Phospholipase A2 (Aptamer 15) (ID# 7536)
Human Nonpancreatic Secretory Phospholipase A2 (hnps-PLA2)
GGGAAAAGAGACGGCCGGCGCCAUAGCCGAGAUCCGAGGUGUUGCCGAGAA
https://www.aptagen.com/apta-index/
Small Organic
null
null
1.7 nM
Huang, Y. (2012). RNA aptamer-based functional ligands of the neurotrophin receptor, TrkB. J. Pharmacol. Exp. Ther. 82(2012):623-635.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
2'-F-RNA
Neurotrophin receptor, TrkB (C4-3) (ID# 7691)
Neurotrophin receptor, TrkB
GGGAGGACGAUGCGGUCGUAUUAUCCGCUGCACGCCAGACGACUCGCCCGA
https://www.aptagen.com/apta-index/
Protein
null
null
2.1 nM
Lee, Y., Kim, I., Park, S., Kim, Y., Wu, S., Lee, J., Noh, D., Kim, K., Ryu, S. and Suh, P. "Periostin-binding DNA aptamer inhibits breast cancer growth and metastasis." The American Society of Gene & Cell Therapy 21.5 (2013): 1004-13.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
Periostin Aptamer (PNDA-3) (ID# 7890)
Periostin
ACGAGTTGTCGCATGTGCGGTTCAGTCTGGTCCTTCAGCACCGTACAACAA
https://www.aptagen.com/apta-index/
Protein
null
null
1.07 nM
Veeramani, Suresh,et al."An RNA aptamer-based biomarker platform demonstrates high soluble CD25 occupancy by IL2 in the serum of follicular lymphoma patients" American Association for Cancer Research 7, (2019) 1511-1522Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
Tr-8 (ID# 8036)
CD25
GGGAGGACGAUGCGGGCCGUUGUUGUGUGCCGCCCCAGACGACUCGCCCGA
https://www.aptagen.com/apta-index/
Protein
null
null
35.7 nM
Veeramani, Suresh,et al."An RNA aptamer-based biomarker platform demonstrates high soluble CD25 occupancy by IL2 in the serum of follicular lymphoma patients" American Association for Cancer Research 7, (2019) 1511-1522Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
Tr-1 (ID# 8037)
IL2-CD25 Complex
GGGAGGACGAUGCGGUCCUGUCGUCUGUUCGUCCCCAGACGACUCGCCCGA
https://www.aptagen.com/apta-index/
Protein
null
null
67.8 nM
Veeramani, Suresh,et al."An RNA aptamer-based biomarker platform demonstrates high soluble CD25 occupancy by IL2 in the serum of follicular lymphoma patients" American Association for Cancer Research 7, (2019) 1511-1522Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
Tr-7 (ID# 8038)
IL2-CD25 Complex
GGGAGGACGAUGCGGUGAGUCGUUCCCUUCGUCCCCAGACGACUCGCCCGA
https://www.aptagen.com/apta-index/
Protein
null
null
45.0 nM
Yang KA, Barbu M, Halim M, et al. Recognition and sensing of low-epitope targets via ternary complexes with oligonucleotides and synthetic receptors. Nat Chem. 2014;6(11):1003-1008. doi:10.1038/nchem.2058Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Fructose-bisboronic acid aptamer-sensor (ID# 8046)
Fructose
CTCTCGGGACGACGGCTGGCACGTTTGGTTCAAGAATGTGGGTGTCGTCCC
https://www.aptagen.com/apta-index/
Small Organic
null
null
4 nM
Yang KA, Barbu M, Halim M, et al. Recognition and sensing of low-epitope targets via ternary complexes with oligonucleotides and synthetic receptors. Nat Chem. 2014;6(11):1003-1008. doi:10.1038/nchem.2058Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Galactose-bisboronic acid aptamer-sensor (ID# 8047)
Galactose
CTCTCGGGACGACCACTACGCATAGTTTCTATCGCCAGGAAGGGTCGTCCC
https://www.aptagen.com/apta-index/
Small Organic
null
null
13 nM
Yang KA, Barbu M, Halim M, et al. Recognition and sensing of low-epitope targets via ternary complexes with oligonucleotides and synthetic receptors. Nat Chem. 2014;6(11):1003-1008. doi:10.1038/nchem.2058Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Phenylalanine-Cp*Rh(III) sensor (ID# 8048)
Phenylalanine
CTCTCGGGACGACGGACGCTAATCTTACAAGGGCGTAGTGTATGTCGTCCC
https://www.aptagen.com/apta-index/
Small Organic
null
null
3.2 nM
Yang KA, Barbu M, Halim M, et al. Recognition and sensing of low-epitope targets via ternary complexes with oligonucleotides and synthetic receptors. Nat Chem. 2014;6(11):1003-1008. doi:10.1038/nchem.2058Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Tryptophan-Cp*Rh(III) sensor (ID# 8050)
Tryptophan
CTCTCGGGACGACCGCGGTAGTCTTAACCTAAAGCGGTGTCAGGTCGTCCC
https://www.aptagen.com/apta-index/
Small Organic
null
null
1.2 µM
Periera, A., Pina, A., Sousa, D., Ferriera, D., Periera, C., Rodrigues, J., Melo, L., Sales, G., Sousa, S., & Rodrigues, L. (2022). Identification of Novel Aptamers Targeting Cathepsin B-Overexpressing Prostate Cancer Cells, 1–14. https://doi.org/10.1039/d2me00022aMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Apt01 (ID# 8200)
CatB
TGGGGGGCAAGCAATTGGTGTGTGGTGTAGCATCCCCCTGTACCGCGCGGG
https://www.aptagen.com/apta-index/
Protein
null
null
9.0 nM
Song, Yanling; Song, Jia; Wei, Xinyu; Huang, Mengjiao; Sun, Miao; Zhu, Lin; et al. (2020): Discovery of Aptamers Targeting Receptor-Binding Domain of the SARS-CoV-2 Spike Glycoprotein. ChemRxiv. Preprint. https://doi.org/10.26434/chemrxiv.12053535.v2Song, Y., Song, J., Wei, X., Huang, M., Sun, M., Zhu, L., Lin, B., Shen, H., Zhu, Z., and C. Yang. 2020. Discovery of Aptamers Targeting the Receptor-Binding Domain of the SARS-CoV‑2 Spike Glycoprotein. Analytical Chemistry 2020, 92, 9895−9900. https://dx.doi.org/10.1021/acs.analchem.0c01394Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
SARS-CoV-2 Aptamer 1C (ID# 8006)
RBD of the Spike glycoprotein from SARS-CoV-2
CAGCACCGACCTTGTGCTTTGGGAGTGCTGGTCCAAGGGCGTTAATGGACA
https://www.aptagen.com/apta-index/
Protein
null
null
5.8 nM
Sylvestre, M.; Saxby, C.; Kacherovsky, N.; Gustafson, H.; Salipante, S.; Pun, S. Identification of a DNA Aptamer That Binds to Human Monocytes and Macrophages. Bioconjug. Chem. 2020 Aug 9; 31(8): 1899-1907. DOI: 10.1021/acs.bioconjchem.0c00247.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
A2 (ID# 8125)
M0-like and M2-like macrophages and monocytes
GAAGAGTAGATGAAACGTTTTTTCGCCCGATAAAAGGGACGTGCGTCAGACA
https://www.aptagen.com/apta-index/
Cells
null
null
20-45 nM
Hadi Bakhtiari, Abbas Ali Palizban, Hossein Khanahmad, and Mohammad Reza MofidACS Omega 2021 6 (16), 11005-11014DOI: 10.1021/acsomega.1c00876Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
#AP-Cell 1 (ID# 8146)
Aspartate β-Hydroxylase (ASPH)
CGGGACAAGACAACGAACGAACAGGAAGAGAACCGGAATGCAGACGTCAGGG
https://www.aptagen.com/apta-index/
Protein
null
null
47.51 ± 5.86 nM
Hadi Bakhtiari, Abbas Ali Palizban, Hossein Khanahmad, and Mohammad Reza MofidACS Omega 2021 6 (16), 11005-11014DOI: 10.1021/acsomega.1c00876Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
#AP-Cell 3 (ID# 8147)
Aspartate β-Hydroxylase (ASPH)
CCGTATCGCCCAGGCAACTGGGCTAAACTTCCCAGAGGGAACGAAACCTGGG
https://www.aptagen.com/apta-index/
Protein
null
null
65.23 ± 9.61 nM
Liu, M.; Wang, Z.; Tan, T.; Chen, Z.; Mou, X.; Yu, X.; Deng, Y.; Lu, G.; He, N. An Aptamer-Based Probe for Molecular Subtyping of Breast Cancer. Theranostics. 2018, 8, 5772-5783.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
sk6Ea (ID# 7998)
SK-BR-3 cells (HER2 positive)
TCACGCCCGATAAGGGCGATGCCGATCCCTGTGGCCGTAGGGCAGTCCCCTAG
https://www.aptagen.com/apta-index/
Cells
null
null
34.79\u202c-63.85 nM
Lin, N.; Wu, L.; Xu, X.; Wu, Q.; Wang, Y.; Shen, H.; Song, Y.; Wang, H., Zhu, Z.; Kang, D.; Yang, C. Aptamer Generated by Cell-SELEX for Specific Targeting of Human Glioma Cells. ACS Appl. Mater. Interfaces. 2021 Mar 3; 13(8): 9306-9315. DOI: 10.1021/acsami.0c11878.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
S6-1b (ID# 8136)
Membrane protein of glioma cell line SHG44
CACAGGTTCCAGGTAATACCTAAGGGTATGCTCTCGCCTATTATATGGAGCAC
https://www.aptagen.com/apta-index/
Protein
null
null
3.1-44 nM
Wang, L, et al. (2012). Selection of DNA aptamers that bind four organophosphorus pesticides. Biotechnol Lett, 2012(34), 869-874. doi: 10.1007/s10529-012-0850-6Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Phorate (SS4-54) (ID# 7681)
Phorate
AAGCTTTTTTGACTGACTGCAGCGATTCTTGATCGCCACGGTCTGGAAAAAGAG
https://www.aptagen.com/apta-index/
Small Organic
null
null
1.43 µM
Wang, L, et al. (2012). Selection of DNA aptamers that bind four organophosphorus pesticides. Biotechnol Lett, 2012(34), 869-874. doi: 10.1007/s10529-012-0850-6Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Profenofos (SS4-54) (ID# 7682)
Profenofos
AAGCTTTTTTGACTGACTGCAGCGATTCTTGATCGCCACGGTCTGGAAAAAGAG
https://www.aptagen.com/apta-index/
Small Organic
null
null
1.25 µM
Wang, L, et al. (2012). Selection of DNA aptamers that bind four organophosphorus pesticides. Biotechnol Lett, 2012(34), 869-874. doi: 10.1007/s10529-012-0850-6Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Isocarbophos (SS4-54) (ID# 7683)
Isocarbophos
AAGCTTTTTTGACTGACTGCAGCGATTCTTGATCGCCACGGTCTGGAAAAAGAG
https://www.aptagen.com/apta-index/
Small Organic
null
null
0.9 µM
Wang, L, et al. (2012). Selection of DNA aptamers that bind four organophosphorus pesticides. Biotechnol Lett, 2012(34), 869-874. doi: 10.1007/s10529-012-0850-6Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Omethoate (SS4-54) (ID# 7684)
Omethoate
AAGCTTTTTTGACTGACTGCAGCGATTCTTGATCGCCACGGTCTGGAAAAAGAG
https://www.aptagen.com/apta-index/
Small Organic
null
null
2 µM
Congsheng Cheng, Yong Hong Chen, Kim A Lennox, Mark A Behlke, Beverly L Davidson, "In vivo SELEX for Identification of Brain-penetrating Aptamers" Molecular Therapy-Nucleic Acids (2013)2, e67, American Society of Gene & Cell TherapyMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
RNA
A15 (ID# 7919)
Penetrating the Blood Brain Barrier (BBB)
GGGAGGACGAUGCGGCGUAUUGCGCGAGGAUUAUCCGCUCAUCGUUGUUGUUGUGCAGACGACUCGCCCGA
https://www.aptagen.com/apta-index/
Other
null
null
. nM
Sai Jin Xiao, Jun Zuo, Zhi Qiang Zhu, Yong Zhong Ouyang, Xing Lei Zhang, Huan Wen Chen, & Li Zhang (2015) Highly Sensitive DNAzyme Sensor for Selective Detection of Trace Uranium in Ore and Natural Water Samples. Sensors and Actuators B 210 (2015) 656-660Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Uranium DNAzyme (ID# 7950)
Uranium
CACGTCCATCTCTGCAGTCGGGTAGTTAAACCGACCTTCAGACATAGTAAGGGG
https://www.aptagen.com/apta-index/
Other
null
null
n/a nM
"In vitro HER2 protein-induced affinity dissociation of carbon nanotube-wrapped anti-HER2 aptamers for HER2 protein detection" J. H. Niazi, S. K. Verma, S. Niazi and A. Qureshi, Analyst, 2014DOI: https://doi.org/10.1039/C4AN01665CMiyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
H2 (ID# 8226)
HER-2
GGGCCGTCGAACACGAGCATGGTGCGTGGACCTAGGATGACCTGAGTACTGTCC
https://www.aptagen.com/apta-index/
Protein
null
null
270 nM
Wang, L, et al. (2012). Selection of DNA aptamers that bind four organophosphorus pesticides. Biotechnol Lett, 2012(34), 869-874. doi: 10.1007/s10529-012-0850-6Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Phorate (SS2-55) (ID# 7677)
Phorate
AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC
https://www.aptagen.com/apta-index/
Small Organic
null
null
1.11 µM
Wang, L, et al. (2012). Selection of DNA aptamers that bind four organophosphorus pesticides. Biotechnol Lett, 2012(34), 869-874. doi: 10.1007/s10529-012-0850-6Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Profenofos (SS2-55) (ID# 7678)
Profenofos
AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC
https://www.aptagen.com/apta-index/
Small Organic
null
null
1 µM
Wang, L, et al. (2012). Selection of DNA aptamers that bind four organophosphorus pesticides. Biotechnol Lett, 2012(34), 869-874. doi: 10.1007/s10529-012-0850-6Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Isocarbophos (SS2-55) (ID# 7679)
Isocarbophos
AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC
https://www.aptagen.com/apta-index/
Small Organic
null
null
0.83 µM
Wang, L, et al. (2012). Selection of DNA aptamers that bind four organophosphorus pesticides. Biotechnol Lett, 2012(34), 869-874. doi: 10.1007/s10529-012-0850-6Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
DNA
Omethoate (SS2-55) (ID# 7680)
Omethoate
AAGCTTGCTTTATAGCCTGCAGCGATTCTTGATCGGAAAAGGCTGAGAGCTACGC
https://www.aptagen.com/apta-index/
Small Organic
null
null
2.5 µM
K. P. Williams, D. P. Bartel, et al. Bioactive and nuclease-resistant l-DNA ligand of vasopressin. Proc. Natl. Acad. Sci., USA. 94(1997): 11285-11290.Miyakawa, Shin, et al. "Structural and molecular basis for hyperspecificity of RNA aptamer to human immunoglobulin G." RNA Journal 14,(2008): 1154-1163.
L-DNA
L-vasopressin (ID# 7820)
L-vasopressin/arginine vasopressin/AVP/ADH
TCACGTGCATGATAGACGGCGAAGCCGTCGAGTTGCTGTGTGCCGATGCACGTGA
https://www.aptagen.com/apta-index/
Peptide
null
null
1.2 µM