title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Negative brain: an integrative review on the neural processes activated by unpleasant stimuli. | Evolutionary pressure has led the nervous system to guarantee rapid and intense responses to negative events (dangerous, harmful or repugnant). Thus, the 'negative brain' (the set of neural mechanisms triggered by unpleasant or negative stimuli) is equipped with several specific characteristics. This review organizes t... | 18,727,941 |
Usefulness of cell-penetrating peptides to improve intestinal insulin absorption. | Cell-penetrating peptides (CPPs) are a useful tool for delivering therapeutic macromolecules across cell membranes. We previously devised an approach using CPPs without intermolecular cross-linking and showed the efficient delivery of insulin from the intestine to the systemic circulation using a typical CPP, oligoargi... | 18,727,945 |
Selective resistance of taurine-fed mice to isoniazide-potentiated seizures: in vivo functional test for the activity of glutamic acid decarboxylase. | Taurine, 2-aminoethanesulfonic acid, is one of the most abundant free amino acids especially in excitable tissues, with wide physiological actions. We have previously reported that in mice, supplementation of the drinking water with taurine induces alterations in the inhibitory GABAergic system. In taurine-fed mice we ... | 18,727,952 |
Reversible regulation of metastasis by ROS-generating mtDNA mutations. | It has been controversial whether mtDNA mutations are responsible for oncogenic transformation (normal cells to develop tumors), and for malignant progression (tumor cells to develop metastases). To clarify this issue, we created trans-mitochondrial cybrids with mtDNA exchanged between mouse tumor cells that express di... | 18,727,959 |
Impact of runoff on superficial femoral artery endoluminal interventions for rest pain and tissue loss. | While aggressive endoluminal therapy for superficial femoral artery (SFA) occlusive disease is commonplace, the implications of runoff on long-term outcomes of these interventions in patients with rest pain and tissue loss is unclear. Runoff is known to negatively effect graft patency. The aim of this study is to exami... | 18,727,964 |
First report of a late type III endoleak from fabric tears of a Zenith stent graft. | We report a case of a late type III endoleak from a hole in the fabric of the main body of a Zenith bifurcated endograft 7 years after implantation. Abdominal pain and a rapidly expanding aneurysm were eventually followed by rupture. The defect was detected at open surgery, whereas no evidence of endoleak was found at ... | 18,727,968 |
Early Palma procedure after iliac vein injury in abdominal penetrating trauma. | Ligation for penetrating abdominal vein trauma may have better outcome than a vascular reconstruction in an unstable patient. However, symptoms of chronic venous insufficiency may appear over time. We describe our surgical experience with 4 patients who underwent iliac vein ligation followed by venous bypass with a mod... | 18,727,974 |
The weaker sex: is being male a legally cognizable defect, impairment, or disability? | Compared with women, men die from cancer and coronary artery disease in disproportionately higher numbers and are more susceptible to a host of emotional and developmental disorders. The authors of this article consider what scientific proof or evidence would be required to legally recognize "being male" as a disabilit... | 18,727,986 |
Wastewater treatment plants (WWTPs) as a source of sediment contamination by toxic organic pollutants and fecal sterols in a semi-enclosed bay in Korea. | Toxic organic contaminants and a macrobenthic community were assayed in sediments collected near a wastewater treatment plant (WWTP) outfall to assess the impact of WWTP discharges on an aquatic environment. Average concentrations of toxic organic contaminants in sediments from 20 locations were 96.7ng TEQ/kg dry matte... | 18,727,999 |
Inhibition of protein tyrosine phosphatase 1B and alkaline phosphatase by bis(maltolato)oxovanadium (IV). | Vanadate has been recognized as a specific and potent phosphatase inhibitor since its structure is similar to that of phosphate. In this study, we measured the inhibition of glutathione S-transferase-tagged protein tyrosine phosphatase 1B (GST-PTP1B) and alkaline phosphatase (ALP) by the insulin enhancing compounds, bi... | 18,728,000 |
Tyrosine residues as redox cofactors in human hemoglobin: implications for engineering nontoxic blood substitutes. | Respiratory proteins such as myoglobin and hemoglobin can, under oxidative conditions, form ferryl heme iron and protein-based free radicals. Ferryl myoglobin can safely be returned to the ferric oxidation state by electron donation from exogenous reductants via a mechanism that involves two distinct pathways. In addit... | 18,728,007 |
Phospholipase Cgamma2 mediates RANKL-stimulated lymph node organogenesis and osteoclastogenesis. | Phospholipase Cgamma2 (PLCgamma2) is an important signaling effector of multiple receptors in the immune system. Here we show that PLCgamma2-deficient mice displayed impaired lymph node organogenesis but normal splenic structure and Peyer's patches. Receptor activator of NF-kappaB ligand (RANKL) is a tumor necrosis fac... | 18,728,019 |
Congenital atresia of the left coronary artery--myocardial revascularization in two children. | Two patients with congenital atresia of the left coronary artery ostium underwent myocardial revascularization at the age of three years and three months, respectively. The patients were admitted to the hospital with a clinical history of sudden chest pain or short apnea not necessitating resuscitation. Non-invasive ex... | 18,728,035 |
Evidence of epistasis between interleukin 1 and selenoprotein-S with susceptibility to rheumatoid arthritis. | Selenoprotein-S (SELS) is involved in the stress response within the endoplasmic reticulum (ER) and inflammation. Recently, promoter variants in the SELS gene were shown to be associated with plasma levels of interleukin (IL)6, IL1beta and tumour necrosis factor (TNF). It was hypothesised that these variants could infl... | 18,728,048 |
Sudden cardiac death and left ventricular ejection fraction during long-term follow-up after acute myocardial infarction in the primary percutaneous coronary intervention era: results from the HIJAMI-II registry. | To determine the incidence of sudden cardiac death (SCD) according to left ventricular ejection fraction (LVEF) in survivors of myocardial infarction (MI) in the primary percutaneous coronary intervention (PCI) era. A multicentre observational prospective registered cohort study. 18 medical centres in Japan. 4122 conse... | 18,728,065 |
Autistic phenotypes and genetic testing: state-of-the-art for the clinical geneticist. | Autism spectrum disorders represent a group of developmental disorders with strong genetic underpinnings. Several cytogenetic abnormalities or de novo mutations able to cause autism have recently been uncovered. In this study, the literature was reviewed to highlight genotype-phenotype correlations between causal gene ... | 18,728,070 |
Sibutramine-associated QT interval prolongation and cardiac arrest. | To report on a probable association between sibutramine and QT interval prolongation leading to ventricular fibrillation and cardiac arrest. A previously well 51-year-old woman with obesity but no other relevant past medical history or cardiac risk factors was prescribed sibutramine (initial dose 10 mg daily, increased... | 18,728,104 |
Effects of feedback frequency and timing on acquisition, retention, and transfer of speech skills in acquired apraxia of speech. | Two studies examined speech skill learning in persons with apraxia of speech (AOS). Motor-learning research shows that delaying or reducing the frequency of feedback promotes retention and transfer of skills. By contrast, immediate or frequent feedback promotes temporary performance enhancement but interferes with rete... | 18,728,115 |
Polymorphisms in the adiponutrin gene are associated with increased insulin secretion and obesity. | The insulin responsive adiponutrin or patatin-like phospholipase 3 (PNPLA3, previously ADPN) gene shows association with obesity and in vitro adipocyte lipolysis. This study aimed to replicate the association between PNPLA3 variants and obesity, and to investigate their effect on insulin resistance and beta-cell functi... | 18,728,122 |
Comparison of two extracorporeal shock wave therapy techniques for the treatment of painful subcalcaneal spur. A randomized controlled study. | To describe and compare two extracorporeal shock wave therapy techniques for the treatment of painful subcalcaneal spur. Random assignment to two groups of treatment with two and eight months follow-up. The data were collected in outpatients. Forty-five subjects with a history of at least six months of heel pain were s... | 18,728,131 |
Neuropsychological predictors of powered wheelchair use: a prospective follow-up study. | To investigate (1) rates of powered wheelchair use and level of user-rated functional performance at one-month follow-up, and (2) whether psychological variables were prospectively predictive of outcome. Prospective follow-up study. UK hospital-based regional rehabilitation and mobility centre. Volunteer adults with im... | 18,728,137 |
Renal dysfunction in acute stroke: an independent predictor of long-term all combined vascular events and overall mortality. | Acute stroke is the third leading cause of death in western societies after ischemic heart disease and cancer. Although it is an emergency disease sharing the same atherosclerotic risk factors with ischemic heart disease, the association of renal function and stroke is poorly investigated. The present study aims at ass... | 18,728,156 |
EPAC and PKA allow cAMP dual control over DNA-PK nuclear translocation. | We identify a compartmentalized signaling system that identifies a functional role for the GTP exchange factor, exchange protein activated by cAMP (EPAC) coupled to Rap2 in the nucleus. In this system, cAMP regulates the nuclear/cytoplasmic trafficking of DNA-dependent protein kinase (DNA-PK), a critical kinase that ac... | 18,728,186 |
Mass incarceration can explain population increases in TB and multidrug-resistant TB in European and central Asian countries. | Several microlevel studies have pinpointed prisons as an important site for tuberculosis (TB) and multidrug-resistant TB in European and central Asian countries. To date, no comparative analyses have examined whether rises in incarceration rates can account for puzzling differences in TB trends among overall population... | 18,728,189 |
Evidence for an asialoglycoprotein receptor on nonparenchymal cells for O-linked glycoproteins. | B cell-activating factor receptor 3 (BR3)-Fc is an IgG1-receptor dimeric fusion protein that has multiple O-linked glycosylation sites and sialylation levels that can vary in the manufacturing process. Increased sialic acid levels resulted from increased site occupancy with the O-linked N-acetylgalactosamine (GalNAc-Ga... | 18,728,239 |
Nonmelanoma skin cancer and risk for subsequent malignancy. | Individuals with a personal history of nonmelanoma skin cancer (NMSC) may have an increased risk of subsequent noncutaneous malignancies. To test this hypothesis, we carried out a community-based, prospective cohort study. In the CLUE (Give Us a Clue to Cancer and Heart Disease) II cohort, which was established in Wash... | 18,728,282 |
Induction of apoptosis in human cancer cells by candidaspongiolide, a novel sponge polyketide. | Candidaspongiolide (CAN), a novel polyketide from a marine sponge, is the active component of a mixture that was found to be potently cytotoxic in the National Cancer Institute's 60-cell-line screen. Effects of CAN on U251 glioma and HCT116 colorectal cancer cells and on normal fibroblasts were assessed using radiolabe... | 18,728,285 |
Relationship between perceived needs and assessed needs for services in community-dwelling older persons. | We examine the relationship between the perceived needs and assessed needs of community-dwelling seniors. Trained research assistants administered the Naturally Occurring Retirement Community Baseline Survey to 268 community-dwelling older adults in suburban Maryland. Perceived and assessed needs were measured in the d... | 18,728,300 |
Effects of radiation quality on the calibration of kerma-area product meters in x-ray beams. | The calibration coefficients of kerma-area product meters significantly depend on the energy spectrum of the x-ray beam. This effect was examined by measuring the calibration coefficients for several radiation qualities in the range generally used in diagnostic x-ray imaging. The intention was to determine the calibrat... | 18,728,309 |
Prognostic implications of the NT-ProBNP level and left atrial size in non-ischemic dilated cardiomyopathy. | The ratio of peak early diastolic mitral inflow to annular velocity (E/E') and left atrial size could provide prognosis on congestive heart failure (CHF). N-terminal Pro B-type natriuretic peptide (NT-ProBNP) has also been useful for predicting adverse cardiac events. However, it is not clear how these parameters compa... | 18,728,335 |
Enamel tissue engineering using subcultured enamel organ epithelial cells in combination with dental pulp cells. | We describe a strategy for the in vitro engineering of enamel tissue using a novel technique for culturing enamel organ epithelial (EOE) cells isolated from the enamel organ using 3T3-J2 cells as a feeder layer. These subcultured EOE cells retain the capacity to produce enamel structures over a period of extended cultu... | 18,728,352 |
Activation of Sirt1 decreases adipocyte formation during osteoblast differentiation of mesenchymal stem cells. | Mesenchymal stem cells (MSC) can differentiate into osteoblasts, adipocytes, chondrocytes and myoblasts. It has been suggested that a reciprocal relationship exists between the differentiation of MSC into osteoblasts and adipocytes. Peroxisome proliferator-activated receptor gamma2 (PPARgamma2) is a key element for the... | 18,728,353 |
[Evaluation of iQ200 automated urine microscopy analyzer]. | Microscopic examination of urine sediment is one of the most commonly performed tests in the clinical laboratory. However, manual microscopic sediment examination is labor-intensive, time-consuming and imprecise. In this study, we evaluated the analytical performance and clinical usefulness of a recently introduced ima... | 18,728,375 |
Budding yeast 14-3-3 proteins contribute to the robustness of the DNA damage and spindle checkpoints. | Cells respond to DNA or mitotic spindle damage by activating specific pathways that halt the cell cycle to allow for possible repair. Here, we report that inactivation of one of the Saccharomyces cerevisiae 14-3-3 proteins, Bmh1, as well as the bmh1-S189P bmh2 mutant, failed to exhibit normal spindle damage-induced cel... | 18,728,387 |
Mouse models for BRCA1 associated tumorigenesis: from fundamental insights to preclinical utility. | Germline mutations in BRCA1 result in a significant predisposition for breast and ovarian cancer, with frequent LOH of the remaining wild type allele. Soon after the identification of BRCA1, several different knockout mice were generated to study its biological function in vivo. BRCA1, which is involved in DNA double-s... | 18,728,395 |
Usp39 is essential for mitotic spindle checkpoint integrity and controls mRNA-levels of aurora B. | Accurate chromosome segregation relies on the mitotic spindle checkpoint. This checkpoint acts to restrict ubiquitin ligase activity of the Anaphase-promoting complex (APC/C) in mitosis until all chromosomes are bipolarly attached to the mitotic spindle. We performed a functional RNAi-based screen to identify De-ubiqui... | 18,728,397 |
The suppressor of metastasis Nm23-H1 interacts with the Cdc42 Rho family member and the pleckstrin homology domain of oncoprotein Dbl-1 to suppress cell migration. | Tumor invasion and metastasis is regulated by a number of cellular molecules known to be involved in signaling and cytoskeletal rearrangement. One of these molecules is the suppressor of tumor metastasis Nm23-H1 which linked to invasiveness and metastatic potential of human cancers. Nm23-H1 expression is down-regulated... | 18,728,402 |
Case study: the Stanford University School of Medicine and its teaching hospitals. | There is wide variation in the governance and organization of academic health centers (AHCs), often prompted by or associated with changes in leadership. Changes at AHCs are influenced by institutional priorities, economic factors, competing needs, and the personality and performance of leaders. No organizational model... | 18,728,444 |
Comparison of complications in percutaneous coronary intervention patients mobilized at 3, 4, and 6 hours after femoral arterial sheath removal. | The purpose of this research study was to explore groin complication rates of patients mobilized at 3, 4, and 6 hours after femoral arterial sheath removal following a percutaneous coronary intervention procedure. Participants were recruited from those undergoing coronary angioplasty and coronary stent placement at a l... | 18,728,513 |
Adiponectin and insulin resistance in childhood obesity. | To measure adiponectin serum levels in Greek children and adolescents and correlate them with body fat and insulin resistance. Forty-six obese prepubertal children (19 M, 27 F) and 34 obese adolescents (17 M, 17 F) ages 9.33 +/- 1.57 and 13.6 +/- 1.42 years, respectively, and 43 matched control individuals were studied... | 18,728,534 |
Endoscopic endonasal resection of anterior cranial base meningiomas. | The endonasal route may be feasible for the resection of anterior cranial base tumors that abut the paranasal sinuses. There are several case reports and mixed case series discussing this approach. Other than pituitary adenomas, there is a lack of literature describing the outcomes of endonasal approaches for single-tu... | 18,728,567 |
Lower incidence of reoperation with longer shunt survival with adult ventriculoperitoneal shunts placed for hemorrhage-related hydrocephalus. | The incidence of reoperation for ventriculoperitoneal shunts (VPS) in adults, although lower than in pediatric patients, is not insignificant. We hypothesize that adult VPS placed for hemorrhage-related hydrocephalus have a lower incidence of reoperation than those placed for other types of hydrocephalus. We retrospect... | 18,728,570 |
Internal carotid artery aneurysms occurring at the origin of fetal variant posterior cerebral arteries: surgical and endovascular experience. | A fetal variant posterior cerebral artery (fetal PCA) is an embryological remnant in which the PCA is primarily supplied via the anterior cerebral circulation. Internal carotid artery (ICA) aneurysms originating from the takeoff of fetal PCA vessels deserve special attention before surgical or endovascular obliteration... | 18,728,604 |
The X-files in immunity: sex-based differences predispose immune responses. | Despite accumulating evidence in support of sex-based differences in innate and adaptive immune responses, in the susceptibility to infectious diseases and in the prevalence of autoimmune diseases, health research and clinical practice do not address these distinctions, and most research studies of immune responses do ... | 18,728,636 |
Therapeutic efficacy of a herpes simplex virus with radiation or temozolomide for intracranial glioblastoma after convection-enhanced delivery. | The herpes simplex virus-1 (HSV-1)-infected cell protein 0 (ICP0) is an E3 ubiquitin ligase implicated in cell cycle arrest and DNA repair inhibition. Convection-enhanced delivery (CED) of either the replication-defective, ICP0-producing HSV-1 mutant, d106, or the recombinant d109, devoid of all viral genome expression... | 18,728,637 |
Ex vivo chemosensitivity testing and gene expression profiling predict response towards adjuvant gemcitabine treatment in pancreatic cancer. | Efficacy of chemotherapy for pancreatic cancer may be improved by tailoring it to individual chemosensitivity profiles. Identification of nonresponders before initiation of treatment may help to avoid side effects. In this study, primary pancreatic cancer cells were isolated from 18 patients undergoing pancreaticoduode... | 18,728,667 |
Calcipotriol/betamethasone dipropionate in the treatment of psoriasis vulgaris. | Psoriasis is one of the most common skin diseases. The mainstay of treatment for the vast majority of patients is topical therapy. A rising first-line treatment modality for psoriasis vulgaris is the two-compound ointment containing calcipotriol 50 mug/g plus betamethasone dipropionate 0.5 mg/g (Dovobet((R)), Daivobet(... | 18,728,704 |
Treatment of gastrointestinal stromal tumor: focus on imatinib mesylate. | Gastrointestinal stromal tumor (GIST) is a rare primary neoplasm of the gastrointestinal tract, mesentery, or omentum. In the past, surgery has been the only effective treatment. The diagnosis and treatment of GIST has been revolutionized over the past decade, since expression of the receptor tyrosine kinase KIT was sh... | 18,728,705 |
Therapeutic options for chronic myeloid leukemia: focus on imatinib (Glivec, Gleevectrade mark). | Treatment options for chronic myeloid leukemia (CML) have changed dramatically during the last decades. Interferon-alpha treatment and stem cell transplantation (SCT) clearly improved survival over conventional chemotherapy and offered the possibility of complete and durable responses. With the advent of the small mole... | 18,728,706 |
Treatment of prostate cancer: therapeutic potential of targeted immunotherapy with APC8015. | The body's immune system has some capacity to recognize and attack cancerous growths, including prostate cancer. However, various intrinsic characteristics of tumor cells usually limit that capacity. Therapeutically administered immunologic stimuli, such as APC8015, an individualized, ex vivo stimulation of a patient's... | 18,728,723 |
Role of phosphodiesterase 5 in synaptic plasticity and memory. | Phosphodiesterases (PDEs) are enzymes that break down the phosphodiesteric bond of the cyclic nucleotides, cAMP and cGMP, second messengers that regulate many biological processes. PDEs participate in the regulation of signal transduction by means of a fine regulation of cyclic nucleotides so that the response to cell ... | 18,728,748 |
Water Dynamics in Nafion Fuel Cell Membranes: the Effects of Confinement and Structural Changes on the Hydrogen Bond Network. | The complex environments experienced by water molecules in the hydrophilic channels of Nafion membranes are studied by ultrafast infrared pump-probe spectroscopy. A wavelength dependent study of the vibrational lifetime of the O-D stretch of dilute HOD in H(2)O confined in Nafion membranes provides evidence of two dist... | 18,728,757 |
Evaluation of two methods to estimate and monitor bird populations. | Effective management depends upon accurately estimating trends in abundance of bird populations over time, and in some cases estimating abundance. Two population estimation methods, double observer (DO) and double sampling (DS), have been advocated for avian population studies and the relative merits and short-comings ... | 18,728,775 |
Drug-selected human lung cancer stem cells: cytokine network, tumorigenic and metastatic properties. | Cancer stem cells (CSCs) are thought to be responsible for tumor regeneration after chemotherapy, although direct confirmation of this remains forthcoming. We therefore investigated whether drug treatment could enrich and maintain CSCs and whether the high tumorogenic and metastatic abilities of CSCs were based on thei... | 18,728,788 |
Prolonged cholinergic enrichment influences regional cortical activation in early Alzheimer's disease. | Neuroimaging studies of cholinesterase inhibitor (ChEI) treatment in Alzheimer's disease (AD) indicate that the short and long term actions of ChEIs are dissimilar. fMRI studies of the ChEI rivastigmine have focused on its short term action. In this exploratory study the effect of prolonged (20 weeks) rivastigmine trea... | 18,728,791 |
Epidemiology and treatment of post-stroke depression. | Mood depression is a common and serious complication after stroke. According to epidemiological studies, nearly 30% of stroke patients develop depression, either in the early or in the late stages after stroke. Although depression may affect functional recovery and quality of life after stroke, such condition is often ... | 18,728,805 |
A review of ramelteon in the treatment of sleep disorders. | Ramelteon is a selective melatonin receptor (MT(1) and MT(2)) agonist that has been approved by the US Food and Drug Administration for the treatment of insomnia characterized by difficulty with sleep onset. It is the only approved sleep-promoting medication that does not have a direct sedating effect, but rather enhan... | 18,728,808 |
Depression in Parkinson's disease: health risks, etiology, and treatment options. | Depression is found in about 30%-40% of all patients with Parkinson's disease (PD), but only a small percentage (about 20%) receive treatment. As a consequence, many PD patients suffer with reduced health-related quality of life. To address quality of life in depressed PD patients, we reviewed the literature on the hea... | 18,728,814 |
Zosyn (piperacillin/tazobactam) reformulation: Expanded compatibility and coadministration with lactated Ringer's solutions and selected aminoglycosides. | Zosyn((R)) , also known as Tazocin((R)) for injection, contains piperacillin and tazobactam and was approved by the US Food and Drug Administration in 1993 for the treatment of indicated serious infections. In 1995, United States Pharmacopoeia and European Pharmacopoeias reduced the particulate limit for injectables by... | 18,728,835 |
Luminescence properties of Pt(II) complexes containing polypyridine ligands with extended aromatic moieties. | The luminescence properties of eleven Pt(II) complexes containing polypyridine ligands with extended aromatic moieties have been studied, both in acetonitrile fluid solution at 298 K and in butyronitrile rigid matrix at 77 K. For comparison purposes, also the phosphorescence properties of three free ligands at 77 K in ... | 18,728,885 |
Prediction of dropout from respiratory symptoms and airflow limitation in a longitudinal respiratory study. | This study investigated the possibility that employees reporting respiratory symptoms were more likely than asymptomatic workers to dropout of a respiratory study carried out in Norwegian smelters. The study included 3924 employees in 24 Norwegian smelters. They were examined annually using a respiratory questionnaire ... | 18,728,912 |
Predicting longitudinal patterns of psychological distress in older husband caregivers: further analysis of existing data. | Further analysis of existing data from a previous longitudinal study of older husband caregivers sought to determine whether primary objective and subjective stressors drawn from Pearlin's model of caregiving could predict three patterns of psychological distress observed in the sample over 1 year: (a) stable high (n=1... | 18,728,946 |
Perceived stress and resilience in Alzheimer's disease caregivers: testing moderation and mediation models of social support. | The study examined whether social support functioned as a protective, resilience factor among Alzheimer's disease (AD) caregivers. Moderation and mediation models were used to test social support amid stress and resilience. A cross-sectional analysis of self-reported data was conducted. Measures of demographics, percei... | 18,728,949 |
Pulmonary function test in transfusion-dependent beta-thalassemia patients. | Beta-thalassaemia is the most common hemoglobinopathies in our region with treatment of regular blood transfusion. Iron overload and hemosiderosis can cause organ involvement. Recent studies have focused on pulmonary involvement and pathophysiology of lung damage. The goal of this study was to investigate the pulmonary... | 18,728,979 |
Condom use and self-efficacy among female sex workers with steady partners in China. | This study attempted to determine the association of self-efficacy with condom-use practice and to explore reasons of not using condoms among female sex workers (FSWs) with steady partners in China. Data from 309 establishment-based FSWs with steady partners in one Chinese county were collected through a cross-sectiona... | 18,728,985 |
Ecology of E. coli O157:H7 and Salmonella enterica in the primary vegetable production chain. | There is an increased concern that plants might be more important as a carrier for human enteric pathogens like E. coli O157:H7 and Salmonella enterica serovars than previously thought. This review summarizes the knowledge available on the ecology of E. coli O157:H7 and Salmonella enterica in the primary production cha... | 18,728,991 |
Apixaban, an oral, direct inhibitor of activated Factor Xa. | Apixaban is an oral, direct Factor Xa inhibitor that is being developed by Bristol-Myers Squibb Co and Pfizer Inc. Apixaban is currently undergoing phase III clinical trials for cerebrovascular ischemia, deep vein thrombosis and lung embolism, and phase II clinical trials for coronary artery disease. | 18,729,009 |
Preparing for biofilm studies in the field. | In their natural environments, microorganisms are under constant environmental selection to form biofilms. Using aquatic biofilms as an example, this unit illustrates general concepts in field biology and practical suggestions for designing, conducting, and analyzing biofilm experiments at varying distances from the la... | 18,729,052 |
Functional decoupling of BOLD and gamma-band amplitudes in human primary visual cortex. | Although functional magnetic resonance imaging is an important tool for measuring brain activity, the hemodynamic blood oxygenation level dependent (BOLD) response is only an indirect measure of neuronal activity. Converging evidence obtained from simultaneous recording of hemodynamic and electrical measures suggest th... | 18,729,078 |
Dose-dependent growth inhibition in vivo of PC-3 prostate cancer with a reduction in tumoral growth factors after therapy with GHRH antagonist MZ-J-7-138. | Antagonists of growth hormone-releasing hormone (GHRH) inhibit the growth of various cancers and affect tumoral growth factors. We investigated the effect of a new GHRH antagonist MZ-J-7-138 at doses of 1.25, 2.5, 5 and 10 microg/day s.c. on the growth of PC-3 human androgen independent prostate cancers xenografted s.c... | 18,729,085 |
Carotid angioplasty and stenting in octogenarians: is it safe? | Elderly patients have a higher risk of complications in carotid endarterectomy. The aim of the study was to evaluate whether carotid artery stenting (CAS) performed in octogenarians also increases the procedure related risk. 870 patients (male 626) mean age 70.9 +/- 9.3 years underwent 930 CAS for de novo lesions (n = ... | 18,729,151 |
Neuroanatomy of the complex tibial organ of Stenopelmatus (Orthoptera: Ensifera: Stenopelmatidae). | Stenopelmatidae (or "Jerusalem crickets") belong to the atympanate Ensifera, lacking hearing organs in the foreleg tibiae. Their phylogenetic position is controversial, either as a taxon in Tettigonioidea or within the clade of Gryllacridoidea. Similarly, the origin of tibial auditory systems in Ensifera is controversi... | 18,729,154 |
Complications of type 1 diabetes: new molecular findings. | Interventions targeting the treatment of diabetic complications have not been nearly as successful as initially estimated, despite a marked improvement in therapeutic options for diabetes. The need for understanding why some very promising interventions have failed demands a closer look at the pathomechanisms of the co... | 18,729,179 |
Tumor expressed PTHrP facilitates prostate cancer-induced osteoblastic lesions. | Expression of parathyroid hormone-related protein (PTHrP) correlates with prostate cancer skeletal progression; however, the impact of prostate cancer-derived PTHrP on the microenvironment and osteoblastic lesions in skeletal metastasis has not been completely elucidated. In this study, PTHrP overexpressing prostate ca... | 18,729,185 |
Diet diversity and the risk of squamous cell esophageal cancer. | A varied diet may have a favorable role against digestive tract cancers. We analyzed the relationship between diet diversity (i.e. measured by the number of different foods consumed at least once per week) and the risk of esophageal cancer. We considered data from a case-control study conducted between 1992 and 1997 in... | 18,729,191 |
Bicontinuous cyclosporin a loaded water-AOT/Tween 85-isopropylmyristate microemulsion: structural characterization and dermal pharmacokinetics in vivo. | Topical delivery of Cyclosporin A (CysA) is of great interest for the treatment of autoimmune skin disorders. Microemulsion systems prepared by AOT/Tween85/isopropyl myristate (IPM)/water possessing a potentially improved skin bioavailability of CysA were designed. The structure of microemulsions was investigated by di... | 18,729,203 |
Germline transgenesis of zebrafish using the medaka Tol1 transposon system. | Tol1 is a DNA-based transposable element first identified from an albino mutant medaka fish. It has been demonstrated to function as an efficient gene transfer vector in mammalian cells. We now demonstrate Tol1 germline transgenesis in zebrafish. A construct containing the green fluorescence protein (GFP) reporter gene... | 18,729,212 |
Enhancer detection and developmental expression of zebrafish sprouty1, a member of the fgf8 synexpression group. | Signaling pathways mediated by receptor tyrosine kinases (RTKs) are under positive and negative regulation, and misregulation of RTK signaling results in developmental defects and malignancy. A major class of antagonists of Fgf and Egf signaling are the Sprouty proteins. Through an enhancer detection approach, we isola... | 18,729,221 |
A critical evaluation of specific aspects of joint development. | Synovial joint formation has been divided into two phases; the formation of the anlagen of the opposing bones and the interzone and the later formation of the joint cavity. Here we review current theories on the mechanism by which these events are achieved in the joints of the developing limb. | 18,729,226 |
Expression of protocadherin-1 (Pcdh1) during mouse development. | Protocadherin-1 (Pcdh1) is a member of the delta-protocadherin subgroup of non-clustered protocadherins. We studied the expression of Pcdh1 from the early embryonic to the adult stage of mouse development by semi-quantitative RT-PCR and in situ hybridization. Pcdh1 can be detected as early as embryonic day 9.5. In earl... | 18,729,229 |
Expression of TMEM16 paralogs during murine embryogenesis. | The TMEM16 protein family has recently been identified through several different experimental strategies including bioinformatic and microarray-based approaches. In mice and humans, there exist 10 paralogs with each containing eight putative transmembrane domains and a conserved C-terminal domain of unknown function. M... | 18,729,231 |
Antibodies against RNA hydrolyze RNA and DNA. | Immunization of animals with DNA leads to the production of anti-DNA antibodies (Abs) demonstrating both DNase and RNase activities. It is currently not known whether anti-RNA Abs can possess nuclease activities. In an attempt to address this question, we have shown that immunization of three rabbits with complex of RN... | 18,729,241 |
A one-year survey on the use of a powder from Rosa canina lito in acute exacerbations of chronic pain. | This pilot surveillance included 152 patients with acute exacerbations of chronic pain, 124 (Back group) with non-specific low back pain (NSLBP), 20 with NSLBP overridden by osteoarthritic pain (Knee-Hip group), and eight with specific LBP (included in the safety analysis). Patients were recommended the rose hip and se... | 18,729,248 |
Risk factors for neonatal infections in full-term babies in South Korea. | Since 1997, private postnatal care facilities (San-hu-jo-ri-won in Korean) have emerged to take the role of the family. As a result, neonates are now exposed to many people and are very vulnerable to infection. However, there has been no study on the influence of postnatal care facilities on neonatal infection. The aim... | 18,729,294 |
Antenatal cognitive-behavioral therapy for prevention of postpartum depression: a pilot study. | To examine the efficacy of cognitive-behavioral therapy (CBT) for the prevention of postpartum depression (PPD) in "at risk" women. We recruited 927 pregnant women in 6 obstetric and gynecology clinics and screened them using Beck Depression Inventory (BDI). Ninety-nine of the screened women who had significantly high ... | 18,729,297 |
Maternal depression predicts maternal use of corporal punishment in children with attention-deficit/hyperactivity disorder. | We sought to determine if maternal depression contributed to the use of corporal punishment in children with attention-deficit/hyperactivity disorder (ADHD). The data were gathered through chart review of clinic-referred children with ADHD and their mothers who were evaluated at a psychiatric clinic located in a large ... | 18,729,299 |
Iatrogenic gastric dilatation: a rare and transient cause of hepatic-portal venous gas. | Gas in the portal veins is rare and in most cases is associated with serious diseases and poor clinical outcome. A case of gas in the hepatic-portal veins with gastric dilatation, as shown by CT-scanning for abdominal trauma, is reported. The condition was clinically benign and resolved spontaneously. An abdominal CT s... | 18,729,313 |
A spindle cell predominant pancreatic solid-pseudopapillary tumor. | A hitherto unrecognized variant of solid-pseudopapillary tumor (SPT) of the pancreas is reported. The tumor presented in the pancreatic tail of a 44-year-old female patient. It was a well-defined, solid nodule measuring 25 mm in diameter, with homogenous tan gray cut surface. Histologically, the neoplasm was mostly com... | 18,729,314 |
Critical assessment of QSAR models of environmental toxicity against Tetrahymena pyriformis: focusing on applicability domain and overfitting by variable selection. | The estimation of the accuracy of predictions is a critical problem in QSAR modeling. The "distance to model" can be defined as a metric that defines the similarity between the training set molecules and the test set compound for the given property in the context of a specific model. It could be expressed in many diffe... | 18,729,318 |
Synthesis of platinum nanowheels using a bicellar template. | Disk-like surfactant bicelles provide a unique meso-structured reaction environment for templating the wet-chemical reduction of platinum(II) salt by ascorbic acid to produce platinum nanowheels. The Pt wheels are 496 +/-55 nm in diameter and possess thickened centers and radial dendritic nanosheets (about 2-nm in thic... | 18,729,320 |
DNA interaction with antitumor polyamine analogues: a comparison with biogenic polyamines. | Biogenic polyamines, putrescine, spermidine, and spermine, are ubiquitous cellular cations and exert multiple biological functions. Polyamine analogues mimic biogenic polyamines at macromolecular level but are unable to substitute for natural polyamines and maintain cell proliferation, indicating biomedical application... | 18,729,321 |
Lyotropic liquid-crystalline mesophases of [Zn(H2O)6](NO3)2-C12EO10-CTAB-H2O and [Zn(H2O)6](NO3)2-C12EO10-SDS-H2O systems. | The mixture of two surfactants (C12EO10-CTAB and C12EO10-SDS) forms lyotropic liquid-crystalline (LLC) mesophases with [Zn(H2O)6](NO3)2 in the presence of a minimum concentration of 1.75 H2O per C12EO10. The metal ion/C12EO10 mole ratio can be increased up to 8.0, which is a record high metal ion density in an LLC meso... | 18,729,333 |
Light-induced biocidal action of conjugated polyelectrolytes supported on colloids. | A series of water soluble, cationic conjugated polyelectrolytes (CPEs) with backbones based on a poly(phenylene ethynylene) repeat unit structure and tetraakylammonium side groups exhibit a profound light-induced biocidal effect. The present study examines the biocidal activity of the CPEs, correlating this activity wi... | 18,729,335 |
Theoretical study on the phenyl torsional potentials of trans-diphenyldiphosphene. | The phenyl torsional potentials of trans-diphenyldiphosphene ( trans-phosphobenzene; t-DPP), which is an analogue of trans-azobenzene ( t-AZB), have been examined by means of ab initio complete active space self-consistent field (CASSCF) calculations. Though the electronic structures of t-DPP are similar to those of t-... | 18,729,342 |
Binding of ADP in the mitochondrial ADP/ATP carrier is driven by an electrostatic funnel. | The ADP/ATP carrier (AAC) is a membrane protein of paramount importance for the energy-fueling function of the mitochondria, transporting ADP from the intermembrane space to the matrix and ATP in the opposite direction. On the basis of the high-resolution, 2.2-A structure of the bovine carrier, a total of 0.53 micros o... | 18,729,359 |
UV absorption cross-sections of a series of dimethylbenzaldehydes. | The ultraviolet absorption cross-sections of 2,4-, 2,5-, 2,6-, 3,4- and 3,5- dimethylbenzaldehydes are reported in the wavelength range 240-320 nm. The measurements were carried out in the temperature range 318-363 K using two different experimental systems (D 2 lamp-monochromator and D 2 lamp-diode array). The absorpt... | 18,729,433 |
Cyclic ruthenium-alkylidene catalysts for ring-expansion metathesis polymerization. | A series of cyclic Ru-alkylidene catalysts have been prepared and evaluated for their efficiency in ring-expansion metathesis polymerization (REMP). The catalyst structures feature chelating tethers extending from one N-atom of an N-heterocyclic carbene (NHC) ligand to the Ru metal center. The catalyst design is modula... | 18,729,450 |
Nectar Flavonol rhamnosides are floral markers of acacia (Robinia pseudacacia) honey. | With the objective of finding floral markers for the determination of the botanical origin of acacia (robinia) honey, the phytochemicals present in nectar collected from Robinia pseudacacia flowers were analyzed by high-performance liquid chromatography-tandem mass spectrometry. Eight flavonoid glycosides were detected... | 18,729,455 |
Fractionation of honey carbohydrates using pressurized liquid extraction with activated charcoal. | This article describes the development of a new procedure that combines the use of activated charcoal and pressurized liquid extraction (PLE) to obtain enriched fractions of di- and trisaccharides from honey. Honey was adsorbed onto activated charcoal and packed into a PLE extraction cell. Optimum results were obtained... | 18,729,462 |
Mathematical model for mixing reactants in a capillary microreactor by transverse diffusion of laminar flow profiles. | Transverse diffusion of laminar flow profiles (TDLFP) was recently suggested as a generic approach for mixing reactants inside a capillary microreactor. Conceptually, solutions of reactants are injected inside the capillary by high pressure as a series of consecutive plugs. Because of the laminar nature of the flow ins... | 18,729,469 |
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