title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
|---|---|---|
Psycho-social counselling in predictive genetic testing for cancer: the association between number of supportive sessions and client characteristics as assessed by psycho-social workers. | Given the increased demand on genetic services, it is important to identify clients who may require relatively more extensive psychosocial support. This paper describes which client characteristics, as assessed in the first psycho-social counselling session, were associated with requiring relatively more psycho-social ... | 18,751,878 |
A pilot study of dose-dense adjuvant paclitaxel without growth factor support for women with early breast carcinoma. | Granulocyte-colony stimulating factor (G-CSF) was used in CALGB 9741 to support dose-dense sequential chemotherapy with doxorubicin and cyclophosphamide (AC) followed by paclitaxel (P) (Citron et al. J Clin Oncol 21:1431-1439, 2003). However, myelosuppression is not known to be dose or schedule limiting for paclitaxel.... | 18,751,888 |
Synaptic vesicle-bound pyruvate kinase can support vesicular glutamate uptake. | Glucose metabolism is essential for normal brain function and plays a vital role in synaptic transmission. Recent evidence suggests that ATP synthesized locally by glycolysis, particularly via glyceraldehyde 3-phosphate dehydrogenase/3-phosphoglycerate kinase, is critical for synaptic transmission. We present evidence ... | 18,751,889 |
Comparison of nitrogen narcosis and helium pressure effects on striatal amino acids: a microdialysis study in rats. | Exposure to nitrogen-oxygen mixture at high pressure induces narcosis, which can be considered as a first step toward general anaesthesia. Narcotic potencies of inert gases are attributed to their lipid solubility. Nitrogen narcosis induces cognitive and motor disturbances that occur from 0.3 MPa in man and from 1 MPa ... | 18,751,893 |
Constitutive modeling of rate-dependent stress-strain behavior of human liver in blunt impact loading. | An understanding of the mechanical deformation behavior of the liver under high strain rate loading conditions could aid in the development of vehicle safety measures to reduce the occurrence of blunt liver injury. The purpose of this study was to develop a constitutive model of the stress-strain behavior of the human ... | 18,751,900 |
Microarray analysis reveals similarity between CD8+CD28- T cells from young and elderly persons, but not of CD8+CD28+ T cells. | We isolated highly purified CD8+CD28+ and CD8+CD28- T cell populations from healthy young and elderly persons for gene expression profiling using Affymetrix oligonucleotide microarrays. We demonstrate that the gene expression profile of CD8+CD28- T cells is very similar in young and elderly persons. In contrast, CD8+CD... | 18,751,903 |
Fatty acid amide hydrolase: a gate-keeper of the endocannabinoid system. | The family of endocannabinoids contains several polyunsaturated fatty acid amides such as anandamide (AEA), but also esters such as 2-arachidonoylglycerol (2-AG). These compounds are the main endogenous agonists of cannabinoid receptors, able to mimic several pharmacological effects of Delta9-tetrahydrocannabinol (Delt... | 18,751,909 |
MALDI-TOF MS analysis of lipids from cells, tissues and body fluids. | Many diseases as atherosclerosis and metabolic dysfunctions are known to correlate with changes of the lipid profile of tissues and body fluids. Therefore, the importance of reliable methods of lipid analysis is obvious. Although matrix-assisted laser desorption and ionization time-of-flight mass spectrometry (MALDI-TO... | 18,751,926 |
Lipidomics in diagnosis of lipidoses. | A review is presented of the major clinical features of a number of glycolipidoses including Fabry, Gaucher, Tay-Sachs, metachromatic leukodystrophy as well as CeroidLipofucinosis and Sjogren-Larsson syndrome. The possibilities offered by lipidomics for diagnosis and follow-up after enzyme replacement therapy are prese... | 18,751,927 |
Laparoscopic cholecystectomy in patients with a history of gastrectomy. | Previous gastrectomy has been considered a relative contraindication to laparoscopic cholecystectomy (LC). The aim of this study was to evaluate the safety and efficacy of LC in patients with a history of gastrectomy. From a database of 1 104 consecutive patients with symptomatic gallstone disease, who underwent LC bet... | 18,751,943 |
The rapid growth of intraluminal tumor metastases at the intestinal wall sites damaged by obstructive colitis due to sigmoid colon cancer: report of a case. | A 53-year-old woman who was traveling in Australia was admitted to a local hospital with pyrexia and diarrhea. Megacolon was diagnosed from an X-ray and an emergency operation was performed. However, the cause of megacolon was not clear, and the attempted operation ended in a simple laparotomy. Sigmoid cancer was found... | 18,751,956 |
[Diffuse abdominal pain and eosinophilia]. | Eosinophilic gastroenteritis is a rare clinical condition of unknown aetiology and heterogenic etiopathology. Important differential diagnoses are intestinal parasitic infections, hypereosinophilic syndrome, malignancies such as lymphoma and allergic diseases. The diagnosis can be made in most cases by patient history,... | 18,751,963 |
Prospective dosimetry with 99mTc-MDP in metabolic radiotherapy of bone metastases with 153Sm-EDTMP. | On the basis of the encouraging results achieved in several clinical trials and its proven therapeutic efficacy, (153)Sm-ethylene diamine tetramethylene phosphonic acid (EDTMP) has become widely used to palliate pain from bone metastases. The results reported in the literature have led the product suppliers (QUADRAMET,... | 18,751,975 |
Non-operative diagnosis--effect on repeat-operation rates in the UK breast screening programme. | Non-operative diagnosis rates in the UK breast screening programme have improved dramatically from 48.8% in 1994/95 (only nine units achieved the then minimum standard of 70%) to 94% in 2005/06 (only seven units failed to achieve the target of 90%). Preoperative and operative history of all 120,550 women diagnosed with... | 18,751,983 |
Genome-wide distribution of ancestry in Mexican Americans. | Migrations to the new world brought together individuals from Europe, Africa and the Americans. Inter-mating between these migrant and indigenous populations led to the subsequent formation of new admixed populations, such as African and Latino Americans. These unprecedented events brought together genomes that had evo... | 18,752,003 |
Identification of novel gene expression in healing fracture callus tissue by DNA microarray. | Fracture healing requires controlled expression of thousands of genes. Only a small fraction of these genes have been isolated and fewer yet have been shown to play a direct role in fracture healing. The purpose of this study was threefold: (1) to develop a reproducible open femur model of fracture healing that produce... | 18,752,025 |
Staphylococcal cassette chromosome mec (SCCmec) characterization and panton-valentine leukocidin gene occurrence for methicillin-resistant Staphylococcus aureus in Turkey, from 2003 to 2006. | Methicillin-resistant Staphylococcus aureus (MRSA) cause serious community-acquired and nosocomial diseases all over the world. We determined the SCCmec types and occurrence of the PVL gene by using TaqMan real-time PCR method, and correlated these with phenotypic antibiotic susceptibility patterns for MRSA strains col... | 18,752,036 |
Inhibitor of DNA binding-1 overexpression in prostate cancer: relevance to tumor differentiation. | Inhibitor of DNA binding-1 (Id1) is a dominant-negative regulator of basic helix-loop-helix transcription factor, which control malignant cell behaviors in several types of carcinomas. This study aimed to find the relationship between Id1 expression and some clinical parameters. Paraffin-embedded tissue specimens from ... | 18,752,043 |
Mass spectrometric quantification of amino acid oxidation products identifies oxidative mechanisms of diabetic end-organ damage. | Diabetes mellitus is increasingly prevalent worldwide. Diabetic individuals are at markedly increased risk for premature death due to cardiovascular disease. Furthermore, substantial morbidity results from microvascular complications which include retinopathy, nephropathy, and neuropathy. Clinical studies involving dia... | 18,752,069 |
[Up-date on the treatment of serious fungal infections]. | In recent years, there has been an exponential increase in the incidence of severe fungal infections with elevated morbidity-mortality. An attempt is currently being made to obtain faster and more reliable diagnostic tests for a certainty diagnosis and to be able to use clinical criteria to identify patients who could ... | 18,752,076 |
Risk of hypertension and renal dysfunction with an angiogenesis inhibitor sunitinib: systematic review and meta-analysis. | Sunitinib is a multitargeted tyrosine kinase inhibitor used in the treatment of metastatic renal cell carcinoma (RCC) and gastrointestinal stromal tumor (GIST), and undergoing evaluation for other malignancy. Hypertension is one of its major side effects with a substantial variation in the reported incidences among cli... | 18,752,081 |
The syndromes of frontotemporal dysfunction in amyotrophic lateral sclerosis. | Amyotrophic lateral sclerosis is increasingly recognized to be a complex multisystems disorder both at the level of its pathobiology and in the breadth of non-motor manifestations that can accompany it. Paramount among these are disorders of frontotemporal function which can be associated with syndromes of behavioural,... | 18,752,088 |
Barriers in the help-seeking process: a multiple-case study of early-onset dysthymia in Sweden. | The aim of this study was to investigate barriers to diagnosis and adequate treatment of patients with early-onset dysthymia by studying how understandings of illness by patients and providers have evolved and how treatments have been negotiated over time. A theory-testing and explorative multiple-case study design was... | 18,752,107 |
The relationship between alexithymia and salivary cortisol levels in somatoform disorders. | The purpose of this study was to investigate cortisol levels as a function of the hypothalamic-pituitary-adrenal axis (HPA) in relation to alexithymia in patients with somatoform disorders (SFD). Diurnal salivary cortisol was sampled in 32 patients with SFD who also underwent a psychiatric examination and filled in que... | 18,752,108 |
SOCS-3 is associated with vascular invasion and overall survival in hepatocellular carcinoma. | Alteration of the suppressor of cytokine signalling-3 (SOCS-3) has been observed in certain human cancers. However, the clinical role of this short-lived protein in hepatocellular carcinoma (HCC) is not well established. Therefore, we aimed to explore the potential role of SOCS-3 proteins in HCC. Paraffin embedded sect... | 18,752,121 |
Pattern and spectrum of morphology referrals in breast pathology consultation. | We aimed to identify common reasons for second opinion breast pathology referrals at the Pathology Department, Singapore General Hospital, focusing on queries and diagnostic issues raised by referring clinicians and pathologists. Request forms for breast pathology consultations were retrieved from a specialist's corres... | 18,752,122 |
Paget's osteosarcoma and post-radiation osteosarcoma: secondary osteosarcoma at Middlemore Hospital, New Zealand. | To review the clinical and histological features of our cases of Paget's osteosarcoma and post-radiation osteosarcoma. A search through the files of the New Zealand Bone and Soft Tissue Tumour Registry was performed, patients were identified and the relevant details were collated. Thirty-one cases of Paget's osteosarco... | 18,752,128 |
Are positive surgical margins in radical prostatectomy specimens an independent prognostic marker? | A positive surgical margin (PSM) is considered an adverse prognostic indicator in patients undergoing radical prostatectomy (RP). However, there are discrepancies among studies concerning the effect of PSM on prognosis. In addition, the significance of PSM location and extent is uncertain. The aim of this study was to ... | 18,752,153 |
Hazardous use of gamma hydroxybutyrate: driving under the influence. | Focus group discussions elicited descriptive experiences of driving under the influence of gamma hydroxybutyrate (GHB), and uncovered motivations that led participants to decide whether to get behind the wheel after ingesting this illegal psychoactive substance. Of the 51 current and past users interviewed, average age... | 18,752,156 |
Alkyl-functionalized oxide-free silicon nanoparticles: synthesis and optical properties. | Highly monodisperse silicon nanoparticles (1.57 +/- 0.21 nm) are synthesized with a covalently attached alkyl monolayer on a gram scale. Infrared spectroscopy shows that these silicon nanoparticles contain only a few oxygen atoms per nanoparticle. XPS spectra clearly show the presence of unoxidized Si and attached alky... | 18,752,208 |
Computer-aided design and synthesis of nonpeptidic plasmepsin II and IV inhibitors. | Plasmepsins (Plm) II (EC number: 3.4.23.39) and IV (EC number: 3.4.23.B14) are aspartic proteases present in the food vacuole of the malaria parasite Plasmodium falciparum and are involved in host hemoglobin degradation. Based on our established efficient synthetic sequence, a series of inhibitors for Plm II and IV has... | 18,752,222 |
Intracellular uptake and inhibitory activity of aromatic fluorinated amino acids in human breast cancer cells. | Nonproteinogenic amino acids that either occur naturally or are synthesized chemically are becoming important tools in modern drug discovery. In this context, fluorinated amino acids have great potential in the development of novel pharmaceuticals and drugs. To assess whether different fluorinated aromatic amino acid a... | 18,752,223 |
Thiocarbamate-linked peptides by chemoselective peptide ligation. | Peptide chemical ligation chemistries, which allow the chemoselective coupling of unprotected peptide fragments, are useful tools for synthesizing native polypeptides or unnatural peptide-based macromolecules. We show here that the phenylthiocarbonyl group can be easily introduced into peptides on alpha or epsilon amin... | 18,752,254 |
Dose-escalation designs in oncology: ADEPT and the CRM. | The ADEPT software package is not a statistical method in its own right as implied by Gerke and Siedentop (Statist. Med. 2008; DOI: 10.1002/sim.3037). ADEPT implements two-parameter CRM models as described in O'Quigley et al. (Biometrics 1990; 46(1):33-48). All of the basic ideas (use of a two-parameter logistic model,... | 18,752,259 |
A cremophor-free formulation for tanespimycin (17-AAG) using PEO-b-PDLLA micelles: characterization and pharmacokinetics in rats. | Tanespimycin (17-allylamino-17-demethoxygeldanamycin or 17-AAG) is a promising heat shock protein 90 inhibitor currently undergoing clinical trials for the treatment of cancer. Despite its selective mechanism of action on cancer cells, 17-AAG faces challenging issues due to its poor aqueous solubility, requiring formul... | 18,752,263 |
A fast, fully automated cell segmentation algorithm for high-throughput and high-content screening. | High-throughput, high-content screening (HT-HCS) of large compound libraries for drug discovery imposes new constraints on image analysis algorithms. Time and robustness are paramount while accuracy is intrinsically statistical. In this article, a fast and fully automated algorithm for cell segmentation is proposed. Th... | 18,752,283 |
Determination of tenatoprazole enantiomers and their enantioselective pharmacokinetics in rats. | The enantioselective pharmacokinetics of tenatoprazole were studied in Wistar rats after the administration of a single oral dose of rac-tenatoprazole. Serial plasma samples were collected; and the pharmacokinetic behavior of each enantiomer was characterized using a sequential achiral and chiral liquid chromatographic... | 18,752,288 |
Pair distribution function X-ray analysis explains dissolution characteristics of felodipine melt extrusion products. | Solid solutions of felodipine with EUDRAGIT E and EUDRAGIT E/NE were shown to dramatically increase the dissolution rate of felodipine in biorelevant media. Of the two polymer systems, extrudates containing 5% EUDRAGIT NE showed a faster dissolution rate and less recrystallization (no precipitation within 2 h). Althoug... | 18,752,290 |
Attenuation of TCDD-induced oxidative stress by 670 nm photobiomodulation in developmental chicken kidney. | 2,3,7,8-Tetrachlorodibenzo-p-dioxin (TCDD), a potent developmental teratogen inducing oxidative stress and sublethal changes in multiple organs, provokes developmental renal injuries. In this study, we investigated TCDD-induced biochemical changes and the therapeutic efficacy of photobiomodulation (670 nm; 4 J/cm(2)) o... | 18,752,309 |
Prolonged survival of patients with lung adenocarcinoma expressing XAGE-1b and HLA class I antigens. | XAGE-1b is a cancer/testis antigen that has been shown to be expressed at a significant frequency and to be immunogenic in non-small cell lung cancer (NSCLC). In the present study, we investigated correlations between XAGE-1b expression and NSCLC patient survival. XAGE-1b expression was examined immunohistochemically u... | 18,752,338 |
[Effect of endothelin-1 on tumor arteries in patients with colorectal cancer]. | Endothelin-1 is an endothelium-derived vasoconstrictor peptide whose plasma levels are increased in patients with colorectal cancer, and which may be involved in tumor blood flow regulation. To study whether response to this peptide is altered in tumor arteries, mesenteric arteries supplying blood flow to colorectal tu... | 18,752,360 |
Safety, efficacy, and dosing requirements of bivalirudin in patients with heparin-induced thrombocytopenia. | To evaluate the safety, efficacy, and dosing requirements of bivalirudin in patients with heparin-induced thrombocytopenia (HIT). Retrospective cohort study. University-affiliated hospital. Thirty-seven adults with a diagnosis or history of HIT who were treated with bivalirudin between January 1, 2004, and March 31, 20... | 18,752,382 |
Research in women and special populations. | The American College of Clinical Pharmacy charged a Task Force on Research in Special Populations to review, update, and broaden its 1993 White Paper on Women as Research Subjects. Participants of the task force included pharmacy clinicians and investigators in the field. This resulting White Paper, Research in Women a... | 18,752,392 |
Socioeconomic disparities affect prefrontal function in children. | Social inequalities have profound effects on the physical and mental health of children. Children from low socioeconomic status (SES) backgrounds perform below children from higher SES backgrounds on tests of intelligence and academic achievement, and recent findings indicate that low SES (LSES) children are impaired o... | 18,752,394 |
Dissociation of frontal and medial temporal lobe activity in maintenance and binding of sequentially presented paired associates. | Substructures of the prefrontal cortex (PFC) and the medial-temporal lobe are critical for associating objects presented over time. Previous studies showing frontal and medial-temporal involvement in associative encoding have not addressed the response specificity of these regions to different aspects of the task, whic... | 18,752,401 |
All numbers are not equal: an electrophysiological investigation of small and large number representations. | Behavioral and brain imaging research indicates that human infants, humans adults, and many nonhuman animals represent large nonsymbolic numbers approximately, discriminating between sets with a ratio limit on accuracy. Some behavioral evidence, especially with human infants, suggests that these representations differ ... | 18,752,403 |
When time shapes behavior: fMRI evidence of brain correlates of temporal monitoring. | Time processing may shape behavior in several ways, although the underlying neural correlates are still poorly understood. When preparatory intervals between stimuli vary randomly in a block, for instance, responses are faster as the interval gets longer. This effect, known as variable foreperiod (FP) effect, has been ... | 18,752,413 |
Immune mechanisms in thyroid eye disease. | Thyroid eye disease (TED) is an inflammatory condition of the orbit closely associated with Graves' disease. During the course of TED, fibrosis can develop around the extraocular muscles, and excess extracellular matrix and fat accumulates in the periorbital space. This dramatic remodeling results in protrusion of the ... | 18,752,427 |
Decreasing listeriosis mortality in the United States, 1990-2005. | Listeria monocytogenes is among the most virulent foodborne pathogens, with 20% of clinical infections resulting in death. To explore listeriosis-associated mortality in the United States and to evaluate prevention efforts, we reviewed vital records over a 16-year period to assess demographic, temporal, and seasonal tr... | 18,752,441 |
Preferential protection of Borrelia burgdorferi sensu stricto by a Salp15 homologue in Ixodes ricinus saliva. | Ixodes ticks are the main vectors for Borrelia burgdorferi sensu lato. In the United States, B. burgdorferi is the sole causative agent of Lyme borreliosis and is transmitted by Ixodes scapularis. In Europe, 3 Borrelia species-B. burgdorferi, B. garinii, and B. afzelii-are prevalent, which are transmitted by Ixodes ric... | 18,752,445 |
p.Ala546 > Asp and p.Arg555 > Trp mutations of TGFBI gene and their clinical manifestations in two large Chinese families with granular corneal dystrophy type I. | The aim of this study was to conduct clinical, genetic, and molecular analysis of Chinese patients with granular corneal dystrophy type I (CDGG1). Two large unrelated Chinese families with CDGG1 were clinically and genetically evaluated. Molecular genetic analysis was performed on DNA extracted from peripheral blood. E... | 18,752,451 |
Effect of cyclosporin A and tacrolimus on sister chromatid exchange frequency in renal transplant patients. | Long-term use of Cyclosporin A (CsA) and Tacrolimus is known to yield serious untoward side effects including nephrotoxicity, neurotoxicity, and malignant tumor formation. Sister chromatid exchange (SCE) is used to assess the genotoxic potential of various agents. A total of 37 postrenal transplant patients receiving e... | 18,752,452 |
Novel TFAP2B mutation in nonsyndromic patent ductus arteriosus. | Mutations in the gene encoding the TFAP2B transcription factor can cause Char syndrome with cardiac, craniofacial, and hand abnormalities. However, TFAP2B mutations result in great phenotypic variability, which is believed to reflect different expression patterns of tissue-specific TFAP2 coactivators. We investigated a... | 18,752,453 |
Fluorescence microscopy as a tool for in situ life detection. | The identification of extant and, in some cases, extinct bacterial life is most convincingly and efficiently performed with modern high-resolution microscopy. Epifluorescence microscopy of microbial autofluorescence or in conjunction with fluorescent dyes is among the most useful of these techniques. We explored fluore... | 18,752,456 |
Supplementation with active hexose correlated compound increases survival following infectious challenge in mice. | Active hexose correlated compound (AHCC) is a fermented mushroom extract that is promoted for immune support. This review focuses on results from in vivo studies evaluating the effects of AHCC supplementation on survival and the immune response to a variety of infectious agents, including influenza virus, avian influen... | 18,752,476 |
TNF/IL-1/NIK/NF-kappa B transduction pathway: a comparative study in normal and pathological human prostate (benign hyperplasia and carcinoma). | Tumour necrosis factor (TNF)-alpha induces death or cell proliferation by activation of nuclear factor (NF)-kappaB, also activated by interleukin (IL)-1 alpha. The aim was to investigate upstream and downstream components of NIK transduction pathway in normal (NP), benign prostatic hyperplasia (BPH), prostatic intraepi... | 18,752,500 |
Gender-related differences in cataract surgery outcome: a 5-year follow-up. | A prospective, longitudinal, population-based cohort study was performed to analyse gender-related differences in subjective and objective visual function 5 years after cataract surgery. All patients (n = 810) who underwent cataract surgery during a 1-year period (1997-98) at Norrlands University Hospital in Umeå, Swed... | 18,752,528 |
Ultrasound biomicroscopy of zonular anatomy in clinically unilateral exfoliation syndrome. | To evaluate the ability of ultrasound biomicroscopy (UBM) to detect abnormalities in the zonular apparatus in unaffected eyes of patients with clinically unilateral exfoliation syndrome (XFS) using a standardized grading system. The affected and unaffected eyes of 17 patients with clinically unilateral XFS and 17 eyes ... | 18,752,530 |
Erroneous automated optical platelet counts in 1-hour post-transfusion blood samples. | Thrombocytopenic patients with acute leukemia may show high post-transfusion count increments that significantly exceed the number of transfused platelets. This study demonstrates that the automated hematology analyzer Sysmex XE-2100 reports erroneously high optical platelet counts when the blood sample contains partic... | 18,752,538 |
Clinical experiences of solid pseudopapillary tumors of the pancreas in China. | To discuss the clinical experiences of solid pseudopapillary tumors (SPTs) of the pancreas by summarizing clinical information of patients with this disease in China. Chinese literature concerning SPTs of the pancreas published between January 1996 and October 2006 were retrospectively reviewed and analyzed. A total of... | 18,752,561 |
Factor V Leiden is associated with pre-eclampsia but not with fetal growth restriction: a genetic association study and meta-analysis. | Adverse pregnancy outcomes have been related to environmental and/or genetic factors. Of interest are genes associated with the clotting system as any perturbation in the balance of thrombotic and thrombolytic cascades could affect the placental circulation and hence the viability of the developing fetus. Several previ... | 18,752,569 |
Adhesive receptors, extracellular proteins and myosin IIA orchestrate proplatelet formation by human megakaryocytes. | Megakaryocytes release platelets from the tips of cytoplasmic extensions, called proplatelets. In humans, the regulation of this process is still poorly characterized. To analyse the regulation of proplatelet formation by megakaryocyte adhesion to extracellular adhesive proteins through different membrane receptors. Hu... | 18,752,571 |
Bispecific targeting of thrombin activatable fibrinolysis inhibitor and plasminogen activator inhibitor-1 by a heterodimer diabody. | Thrombin activatable fibrinolysis inhibitor (TAFI) and plasminogen activator inhibitor-1 (PAI-1) play important roles in fibrinolysis. Both reduce plasmin generation, but they exert their antifibrinolytic effects via different mechanisms. This study reports the cloning and characterization of a heterodimer diabody that... | 18,752,580 |
Interaction of the active metabolite of prasugrel, R-138727, with cysteine 97 and cysteine 175 of the human P2Y12 receptor. | The P2Y(12) receptor plays a crucial role in platelet aggregation and is the target of platelet aggregation inhibitors, including the thienopyridine compound prasugrel. The present study analyzed the effects of R-138727 (2-[1-[2-cyclopropyl-1-(2-fluorophenyl)-2-oxoethyl]-4-mercapto-3-piperidinylidene]acetic acid), the ... | 18,752,581 |
Polymorphisms in the kappa casein (CSN3) gene in horse and comparative analysis of its promoter and coding region. | The major parts of the coding region and promoter of the equine kappa casein (CSN3) gene were sequenced and compared among several species. Four SNPs were identified in the CSN3 gene: two in exon 1 and two in exon 4. The SNPs were genotyped in six Slovenian horse breeds using RFLP and two different PCR-based methods. T... | 18,752,583 |
Titrated low-dose vaginal and/or oral misoprostol to induce labour for prelabour membrane rupture: a randomised trial. | To evaluate the clinical effectiveness and safety of titrated low-dose misoprostol for induction of labour (IOL) in the presence of prelabour rupture of membranes (PROM). Randomised controlled trial. Maternity units in the UK (9) and Egypt (1). Women >34 weeks of gestation with PROM, singleton viable fetus and no pr... | 18,752,586 |
On the adaptive accuracy of directional asymmetry in insect wing size. | Subtle left-right biases are often observed in organisms with an overall bilateral symmetry. The evolutionary significance of these directional asymmetries remains uncertain, however, and scenarios of both developmental constraints and adaptation have been suggested. Reviewing the literature on asymmetry in insect wing... | 18,752,614 |
An evolutionary expressed sequence tag analysis of Drosophila spermatheca genes. | This study investigates genes enriched for expression in the spermatheca, the long-term sperm storage organ (SSO) of female Drosophila. SSO genes are likely to play an important role in processes of sexual selection such as sperm competition and cryptic female choice. Although there is keen interest in the mechanisms o... | 18,752,616 |
Allelopathic growth inhibition by the toxic, bloom-forming cyanobacterium Planktothrix rubescens. | Blooms of freshwater cyanobacteria are typically accompanied by an important decrease in phytoplankton biodiversity in the water bodies where they occur. This study examines the potential production of growth-inhibiting substances by the toxic, bloom-forming cyanobacterium Planktothrix rubescens, following the observat... | 18,752,621 |
Proteomic identification of nitrated brain proteins in early Alzheimer's disease inferior parietal lobule. | Alzheimer's disease (AD) is a neurodegenerative disorder characterized by progressive decline in multiple cognitive domains. Its pathological hallmarks include senile plaques and neurofibrillary tangles. Mild cognitive impairment (MCI) is the earliest detectable stage of AD with limited symptomology and no dementia. Th... | 18,752,637 |
A post-mortem survey on end-of-life decisions using a representative sample of death certificates in Flanders, Belgium: research protocol. | Reliable studies of the incidence and characteristics of medical end-of-life decisions with a certain or possible life shortening effect (ELDs) are indispensable for an evidence-based medical and societal debate on this issue. This article presents the protocol drafted for the 2007 ELD Study in Flanders, Belgium, and o... | 18,752,659 |
Osteoid osteoma of a metacarpal bone: a case report and review of the literature. | Osteoid osteoma is a benign tumor of the growing skeleton. It presents with pain, which is usually worse at night. The radiographic features consist of a central oval or round nidus surrounded first by a radiolucent area followed by another area of sclerotic bone. In the hand, osteoid osteoma is more commonly located i... | 18,752,665 |
Identification and correction of abnormal, incomplete and mispredicted proteins in public databases. | Despite significant improvements in computational annotation of genomes, sequences of abnormal, incomplete or incorrectly predicted genes and proteins remain abundant in public databases. Since the majority of incomplete, abnormal or mispredicted entries are not annotated as such, these errors seriously affect the reli... | 18,752,676 |
A cross-sectional study to determine the seroprevalence of bluetongue virus serotype 8 in sheep and goats in 2006 and 2007 in the Netherlands. | In August 2006 a major epidemic of bluetongue virus serotype 8 (BTV8) started off in North-West Europe. In the course of 2007 it became evident that BTV8 had survived the winter in North-West Europe, re-emerged and spread exponentially. Recently, the European Union decided to start vaccination against BTV8. In order to... | 18,752,681 |
Executive dysfunction correlates with impaired functional status in older adults with varying degrees of cognitive impairment. | Previous studies have reported an association between executive dysfunction and the ability to perform activities of daily living (ADL)s among older adults. This study aims to examine the association between executive functions and functional status in a cross-section of older adults with varying degrees of cognitive i... | 18,752,698 |
Phylogenetic analysis of Trypanosoma vivax supports the separation of South American/West African from East African isolates and a new T. vivax-like genotype infecting a nyala antelope from Mozambique. | In this study, we addressed the phylogenetic and taxonomic relationships of Trypanosoma vivax and related trypanosomes nested in the subgenus Duttonella through combined morphological and phylogeographical analyses. We previously demonstrated that the clade T. vivax harbours a homogeneous clade comprising West African/... | 18,752,705 |
Anti-VSG antibodies induce an increase in Trypanosoma evansi intracellular Ca2+ concentration. | Trypanosoma evansi and Trypanosoma vivax have shown a very high immunological cross-reactivity. Anti-T. vivax antibodies were used to monitor changes in the T. evansi intracellular Ca2+ concentration ([Ca2+]i) by fluorometric ratio imaging from single parasites. A short-time exposure of T. evansi parasites to sera from... | 18,752,709 |
Cardiac resynchronization therapy: application of imaging to optimize patient selection and assess response. | Cardiac resynchronization therapy (CRT) has been shown to be effective for advanced heart failure and discoordinate wall motion, although the nonresponse rate for patients meeting standard CRT criteria remains about 30%. Although electrical delay (wide QRS) is commonly used to select candidates, recent data show that d... | 18,752,761 |
In-capillary derivatization and capillary electrophoresis separation of amino acid neurotransmitters from brain microdialysis samples. | A new in-capillary derivatization method with naphtalene-2,3-dicarboxyaldehyde (NDA)/CN(-) has been developed for capillary electrophoresis with laser-induced fluorescence detection of brain microdialysate amino acids. Samples are sandwiched between two plugs of reagent mixture at the capillary inlet and subsequently s... | 18,752,800 |
Development of cultural strategies of attention in North American and Japanese children. | Recent studies suggest that North American adults exhibit a focused strategy of attention that emphasizes focal information about objects, whereas Japanese adults exhibit a divided strategy of attention that emphasizes contextual information about objects. The current study investigated whether 4- and 5-, 6- to 8-, and... | 18,752,808 |
Model approach for estimating potato pesticide bioconcentration factor. | We presented a model that estimates the bioconcentration factor (BCF) of pesticides in potatoes supposing that the pesticide in the soil solution is absorbed by the potato by passive diffusion, following Fick's second law. The pesticides in the model are nonionic organic substances, traditionally used in potato crops t... | 18,752,828 |
Innovative PCDD/F-containing gas stream generating system applied in catalytic decomposition of gaseous dioxins over V2O5-WO3/TiO2-based catalysts. | Development of effective PCDD/F (polychlorinated dibenzo-p-dioxin and dibenzofuran) control technologies is essential for environmental engineers and researchers. In this study, a PCDD/F-containing gas stream generating system was developed to investigate the efficiency and effectiveness of innovative PCDD/F control te... | 18,752,829 |
The extent of active processing of a long-duration stimulus modulates the scalp-recorded sustained potential. | A long-duration stimulus will elicit a negative sustained potential (SP) that is maximum in amplitude over fronto-central areas of the scalp. This study examines how the duration of active attentional processing of the stimulus might also elicit a nonsensory contingent negative variation (CNV) that overlaps and summate... | 18,752,881 |
Risk for excessive alcohol use and drinking-related problems in college student athletes. | There is compelling evidence that college student athletes engage in frequent episodes of heavy drinking and are prone to negative consequences resulting from such use. This study sought to identify risk and protective factors associated with student-athlete drinking and determine if student-athlete risk factors differ... | 18,752,900 |
The catechol-O-methyltransferase (COMT) gene polymorphism and prevalence of uterine fibroids. | To assess the possible association between the catechol-O-methyltransferase (COMT) polymorphism and uterine fibroids in Brazilian women. Case-control study. Department of Gynecology; teaching hospital. One hundred twenty-four premenopausal women with fibroids, and 193 postmenopausal controls not presenting the disease.... | 18,752,908 |
Effects of biotin deficiency on embryonic development in mice. | The purpose of this investigation was to determine the effects of biotin deficiency on maternal metabolism and embryonic development in pregnant mouse dams. The pregnant mice were randomly assigned to one of three dietary groups and given a biotin-deficient diet, biotin-supplemented diet, or biotin-control diet during ... | 18,752,930 |
Curcumin attenuates the organ dysfunction caused by endotoxemia in the rat. | Curcumin has antioxidant, antitumor, and anti-inflammatory properties. However, it remains unknown whether curcumin has any protective effects on sepsis. The purpose of this study was to demonstrate whether curcumin prevents organ dysfunction in animals with sepsis. Rats were randomized into four groups. The control gr... | 18,752,929 |
Comparative performance and microbial diversity of hyperthermophilic and thermophilic co-digestion of kitchen garbage and excess sludge. | The objective of this study was to evaluate the performance characteristics of a hyperthermophilic digester system that consists of an acidogenic reactor operated at hyperthermophilic (70 degrees C) conditions in series with a methane reactor operated at mesophilic (35 degrees C), thermophilic (55 degrees C), and hyper... | 18,752,938 |
Discovery of novel series of benzoic acid derivatives containing biphenyl ether moiety as potent and selective human beta(3)-adrenergic receptor agonists: Part IV. | Identification and SAR study of novel series of beta(3)-AR agonists with benzoic acid are described. Conversion of ether linkage position of phenoxybenzoic acid derivative 2b led to compound 7b with moderate beta(3)-AR activity. Further modification in right, center and left parts of compound 7b was investigated to imp... | 18,752,946 |
Mobilizations of the asymptomatic cervical spine can reduce signs of shoulder dysfunction in adults. | Generalized shoulder pain is a common problem that is difficult to treat and frequently recurrent. The asymptomatic cervical spine must be ruled out as a cause of any shoulder pain, as it can have a similar presentation to an isolated shoulder disorder. Previous studies have shown that lateral cervical glide mobilizati... | 18,752,983 |
Anticipatory postural control following fatigue of postural and focal muscles. | To investigate the effect of fatigue of postural and focal muscles on anticipatory postural adjustments (APAs). Nine healthy adults performed rapid bilateral arm raising movements before and after isometric hamstring (postural) and deltoid (focal/prime mover) muscle fatigue. Muscle force and peak acceleration of the ar... | 18,752,990 |
Sleep patterns among rural Chinese twin adolescents. | To examine sleep patterns and influencing factors (age, gender, Tanner Stage, weekday vs. weekend, and pre-sleep activity) among rural Chinese adolescents. This is a prospective study among 621 adolescents aged 11-20 years (341 males) using both a questionnaire and sleep diary to obtain bedtime, wake-up time, sleep lat... | 18,752,997 |
Periodic leg movements in RLS patients as compared to controls: Are there differences beyond the PLM index? | To characterize periodic leg movements (PLM) and their association with sleep disturbances in drug-free patients with restless legs syndrome (RLS) and healthy subjects without sleep complaints. Polysomnographic recordings of 95 patients with idiopathic RLS and 31 age-matched controls were compared, and correlation anal... | 18,753,004 |
A finite element study on the effects of disorder in cellular structures. | The susceptibility to deformation localization of simple cubic arrangements of struts, which are a simple approximation of the micro-architecture in cancellous bone, is analyzed. The coherence between structural disorder and the tendency towards deformation localization is investigated and its relevance from a biologic... | 18,753,022 |
[Effect of maternal BDE-209 exposure on the expression of GAP-43 and BDNF in the hippocampus of the offspring rats]. | To evaluate the effect of prenatal and lactational exposure to brominated diphenyl ethers-209 (BDE-209) on the expression of growth associated protein-43 (GAP-43) and brain-derived neurotrophic factors (BDNF) in the hippocampus of the offspring rats. Peanut oil suspensions of commercial BDE-209 were administered daily ... | 18,753,049 |
[Effects of ruthenium red on body temperature in rats with lipopolysaccharide-induced fever]. | To observe the effect of ruthenium red (RR) on the body temperature of rats with lipopolysaccharide (LPS)-induced fever and investigate the possible mechanism. Rat models of fever were established with lipopolysaccharide and the effects of RR at different doses were observed on the body temperature of the rats and the ... | 18,753,064 |
[Effect of peptide YY on subcutaneous transplantation tumor of human hepatoma in nude mice]. | To investigate the effects of peptide YY (PYY) on subcutaneous transplantation tumor of human hepatoma in nude mice and preliminarily explore the mechanisms. HepG2 human hepatic carcinoma cells were injected into nude mice subcutaneously, and the resultant tumor were taken and prepared into small tissue blocks. The tis... | 18,753,082 |
[Construction of a three-dimensional mandible model containing teeth based on the Virtual Chinese Human data]. | To construct a three-dimensional (3D) model of the mandible containing the teeth based on the Virtual Chinese Human Data. From the previously established Virtual Chinese Human Dataset, 280 consecutive images containing the mandibular region were taken as a source data for reconstruction of the 3D mandible model. The Ph... | 18,753,084 |
Metabolic effects of 2 days of strict bed rest. | To examine the possibility of whether 2 days of strict hospitalized bed rest would alter the metabolic profile (including insulin resistance as calculated by the quantitative insulin sensitivity check index or QUICKI) in both normal subjects and patients with type 2 diabetes in comparison with 2 days of normal activity... | 18,753,098 |
Treatment of altered body composition in HIV-associated lipodystrophy: comparison of rosiglitazone, pravastatin, and recombinant human growth hormone. | Treatment options for HIV-associated lipodystrophy syndrome (HALS) remain limited. The objective of this randomized open-label study was to compare three emerging therapies, rosiglitazone, pravastatin, and growth hormone alone and together, in men and women with HALS. Sixty-four subjects received daily rosiglitazone (4... | 18,753,120 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.