title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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The significance of low-level plasma HIV viral load on COBAS TaqMan HIV-1 assays for patients with undetectable plasma viral load on COBAS Amplicor monitor version 1.5. | COBAS TaqMan assay is a new HIV assay for measuring plasma viral load (VL). A significant number of patients with undetectable plasma VL on Amplicor assay were reported to have detectable VL with TaqMan in the study centre. The aim of the present study was to investigate the significance of detectable VL counts with Ta... | 18,753,122 |
Structural and cell adhesion properties of zebrafish syndecan-4 are shared with higher vertebrates. | The syndecan proteoglycans are an ancient class of receptor, bearing heparan sulfate chains that interact with numerous potential ligands including growth factors, morphogens, and extracellular matrix molecules. The single syndecan of invertebrates appears not to have cell adhesion roles, but these have been described ... | 18,753,130 |
Breakthrough invasive fungal infection in an immunocompromised host while on posaconazole prophylaxis: an omission in patient counseling and follow-up. | Posaconazole (Noxafil (Schering-Plough Corporation) is a triazole antifungal approved in the United States for the treatment of oropharyngeal candidiasis and for the prophylaxis of Candida and Aspergillus infections in the immunocompromised host. Posaconazole is available only as an oral suspension. When used for the p... | 18,753,183 |
CSS-Palm 2.0: an updated software for palmitoylation sites prediction. | Protein palmitoylation is an essential post-translational lipid modification of proteins, and reversibly orchestrates a variety of cellular processes. Identification of palmitoylated proteins with their sites is the foundation for understanding molecular mechanisms and regulatory roles of palmitoylation. Contrasting to... | 18,753,194 |
In vitro and in vivo properties of adenovirus vectors with increased affinity to CD46. | Gene transfer vectors containing adenovirus (Ad) serotype 35 (Ad35) fibers have shown promise for cancer and stem cell gene therapy. In this study, we attempted to improve the in vitro and in vivo infection properties of these vectors by increasing their affinity to the Ad35 fiber receptor CD46. We constructed Ad vecto... | 18,753,195 |
Region between the canine distemper virus M and F genes modulates virulence by controlling fusion protein expression. | Morbilliviruses, including measles and canine distemper virus (CDV), are nonsegmented, negative-stranded RNA viruses that cause severe diseases in humans and animals. The transcriptional units in their genomes are separated by untranslated regions (UTRs), which contain essential transcription and translation signals. D... | 18,753,197 |
Double-stranded RNA adenosine deaminases enhance expression of human immunodeficiency virus type 1 proteins. | ADARs (adenosine deaminases that act on double-stranded RNA) are RNA editing enzymes that catalyze a change from adenosine to inosine, which is then recognized as guanosine by translational machinery. We demonstrate here that overexpression of ADARs but not of an ADAR mutant lacking editing activity could upregulate hu... | 18,753,201 |
Engineered intermonomeric disulfide bonds in the globular domain of Newcastle disease virus hemagglutinin-neuraminidase protein: implications for the mechanism of fusion promotion. | The promotion of membrane fusion by Newcastle disease virus (NDV) requires an interaction between the viral hemagglutinin-neuraminidase (HN) and fusion (F) proteins, although the mechanism by which this interaction regulates fusion is not clear. The NDV HN protein exists as a tetramer composed of a pair of dimers. Base... | 18,753,211 |
Recombination, decreased host specificity and increased mobility may have driven the emergence of maize streak virus as an agricultural pathogen. | Maize streak virus (MSV; family Geminiviridae, genus Mastrevirus), the causal agent of maize streak disease, ranks amongst the most serious biological threats to food security in subSaharan Africa. Although five distinct MSV strains have been currently described, only one of these - MSV-A - causes severe disease in mai... | 18,753,214 |
A third genotype of the human parvovirus PARV4 in sub-Saharan Africa. | PARV4 is a recently discovered human parvovirus widely distributed in injecting drug users in the USA and Europe, particularly in those co-infected with human immunodeficiency virus (HIV). Like parvovirus B19, PARV4 persists in previously exposed individuals. In bone marrow and lymphoid tissue, PARV4 sequences were det... | 18,753,240 |
TLR4 facilitates translocation of bacteria across renal collecting duct cells. | Uropathogenic Escherichia coli (UPEC) are the most frequent causes of urinary tract infections and pyelonephritis. Renal medullary collecting duct (MCD) cells are the intrarenal site to which UPEC strains prefer to adhere and initiate an inflammatory response, but the ability of UPEC strains to translocate across imper... | 18,753,256 |
Complement 5a receptor inhibition improves renal allograft survival. | Complement activation plays a key role in mediating apoptosis, inflammation, and transplant rejection. In this study, the role of the complement 5a receptor (C5aR) was examined in human renal allografts and in an allogenic mouse model of renal transplant rejection. In human kidney transplants with acute rejection, C5aR... | 18,753,257 |
Estradiol replacement enhances sleep deprivation-induced c-Fos immunoreactivity in forebrain arousal regions of ovariectomized rats. | To understand how female sex hormones influence homeostatic mechanisms of sleep, we studied the effects of estradiol (E(2)) replacement on c-Fos immunoreactivity in sleep/wake-regulatory brain areas after sleep deprivation (SD) in ovariectomized rats. Adult rats were ovariectomized and implanted subcutaneously with cap... | 18,753,261 |
AtPTR1 and AtPTR5 transport dipeptides in planta. | Transporters for di- and tripeptides belong to the large and poorly characterized PTR/NRT1 (peptide transporter/nitrate transporter 1) family. A new member of this gene family, AtPTR5, was isolated from Arabidopsis (Arabidopsis thaliana). Expression of AtPTR5 was analyzed and compared with tissue specificity of the clo... | 18,753,286 |
Differential effects of urethane and isoflurane on external urethral sphincter electromyography and cystometry in rats. | Urethane is a common and often preferred anesthetic agent for urodynamic recordings in rats, but its use is often restricted to terminal procedures because of a prolonged duration of action and potentially toxic effects. When urodynamic recordings are part of survival procedures in rodent experimental models, inhalatio... | 18,753,298 |
Gender-specific regulation of mitochondrial fusion and fission gene transcription and viability of cortical astrocytes by steroid hormones. | Astroglia and steroid hormones such as estrogen and progesterone regulate cell growth, function, and protection in the central nervous system (CNS). It appears that astrocytes and steroids act in concert to promote cell survival under pathological conditions. With respect to the role of mitochondrial fusion and fission... | 18,753,308 |
Cortisol response to ACTH stimulation correlates with blood interleukin 6 concentration in healthy humans. | Interleukin 6 (IL6) has the ability to influence each level of the hypothalamo-pituitary-adrenocortical (HPA) axis. The aim of the study was to test whether IL6 concentration correlates with the adrenal cortex response to ACTH in healthy humans. We postulated that higher basal IL6 concentration would be associated with... | 18,753,312 |
Beta2-integrins contribute to skeletal muscle hypertrophy in mice. | We tested the contribution of beta(2)-integrins, which are important for normal function of neutrophils and macrophages, to skeletal muscle hypertrophy after mechanical loading. Using the synergist ablation model of hypertrophy and mice deficient in the common beta-subunit of beta(2)-integrins (CD18(-/-)), we found tha... | 18,753,316 |
Enhancement of human antigen-specific memory T-cell responses by interleukin-7 may improve accuracy in diagnosing tuberculosis. | Children and immunocompromised adults are at an increased risk of tuberculosis (TB), but diagnosis is more challenging. Recently developed gamma interferon (IFN-gamma) release assays provide increased sensitivity and specificity for diagnosis of latent TB, but their use is not FDA approved in immunocompromised or pedia... | 18,753,334 |
Proportions of Mycobacterium massiliense and Mycobacterium bolletii strains among Korean Mycobacterium chelonae-Mycobacterium abscessus group isolates. | Korean isolates of the Mycobacterium chelonae-Mycobacterium abscessus group, which had been isolated from two different hospitals in South Korea, were identified by PCR restriction analysis (PRA) and comparative sequence analysis of 16S rRNA genes, rpoB, and hsp65 to evaluate the proportion of four closely related spec... | 18,753,344 |
Femoral prosthesis infection by Rhodotorula mucilaginosa. | This case report is a case history of a femoral prosthesis infection caused by Rhodotorula mucilaginosa in a human immunodeficiency virus patient. Though the pathogenicity of this organism for bone tissue has been previously reported, this is the first reported case of an orthopedic prosthesis infection by this species... | 18,753,353 |
Detection of resistance to macrolides in thermotolerant campylobacter species by fluorescence in situ hybridization. | The resistance of enteritis-causing Campylobacter strains to erythromycin is an emerging problem. We therefore evaluated fluorescence in situ hybridization (FISH) for the rapid detection of resistance using 74 campylobacter isolates. FISH showed specificity and sensitivity of 100% for the detection of high-level resist... | 18,753,354 |
Assay for 5' noncoding region analysis of all human rhinovirus prototype strains. | Increasing recognition of the association of rhinovirus with severe lower respiratory tract illnesses has clarified the need to understand the relationship between specific serotypes of rhinovirus and their clinical consequences. To accomplish this, a specific and sensitive assay to detect and serotype rhinovirus direc... | 18,753,359 |
Pituitary tumor-transforming gene in endocrine and other neoplasms: a review and update. | Pituitary tumor-transforming gene (PTTG) was only recently discovered. Its overexpression occurs in a wide variety of endocrine and non-endocrine tumors, including ones of pituitary, thyroid, ovary, breast, prostate, lung, esophagus, colon, and the central nervous system. It affects tumor invasiveness and recurrence in... | 18,753,362 |
Array-CGH identifies cyclin D1 and UBCH10 amplicons in anaplastic thyroid carcinoma. | Anaplastic thyroid cancer (ATC) is a rare but highly aggressive disease with largely unexplained etiology and molecular pathogenesis. In this study, we analyzed genome-wide copy number changes, BRAF (V-raf sarcoma viral oncogene homolog B1) mutations, and p16 and cyclin D1 expressions in a panel of ATC primary tumors. ... | 18,753,363 |
Recurrent inhibitory network among striatal cholinergic interneurons. | The striatum plays a central role in sensorimotor learning and action selection. Tonically active cholinergic interneurons in the striatum give rise to dense axonal arborizations and significantly shape striatal output. However, it is not clear how the activity of these neurons is regulated within the striatal microcir... | 18,753,369 |
Preferential enhancement of dopamine transmission within the nucleus accumbens shell by cocaine is attributable to a direct increase in phasic dopamine release events. | Preferential enhancement of dopamine transmission within the nucleus accumbens (NAc) shell is a fundamental aspect of the neural regulation of cocaine reward. Despite its importance, the nature of this effect is poorly understood. Here, we used fast-scan cyclic voltammetry to examine specific transmission processes und... | 18,753,384 |
Assay validation and biological variation of serum receptor for advanced glycation end-products. | The analytical performance characteristics of an enzyme-linked immunosorbent assay for the receptor for advanced glycation end-products (RAGE) were evaluated. The within- and between-subject components of biological variation were also estimated. Blood was sampled from healthy volunteers into K(2)-ethylenediamine tetra... | 18,753,428 |
Identification and expression profile of a novel alternative splicing of Pax7 in chick skeletal muscle. | Pax7 is essential for skeletal muscle myogenesis. The alternative splicing forms of Pax7 were found in human and mouse. In this study, we identified a new alternative splicing of chick Pax7. We named it Pax7-2 and localized it in the nucleus of chick myoblast. In Pax7-2 mRNA, exon 8 of chick Pax7 gene was spliced out. ... | 18,753,463 |
8-Isoprostane in exhaled breath condensate and exercise-induced bronchoconstriction in asthmatic children and adolescents. | Exercise-induced bronchoconstriction (EIB) in the asthmatic child is associated with persistent airway inflammation and poor disease control. EIB could arise partly from airway oxidative stress. Exhaled breath condensate (EBC) levels of 8-isoprostane (IsoP), which is a known marker of oxidative stress, might therefore ... | 18,753,466 |
Progesterone regulates FGF10, MET, IGFBP1, and IGFBP3 in the endometrium of the ovine uterus. | Progesterone (P4) is unequivocally required to maintain a uterine environment conducive to pregnancy. This study investigated the effects of P4 treatment on expression of selected growth factors (fibroblast growth factor 7 [FGF7], FGF10, hepatocyte growth factor [HGF], and insulin-like growth factors [IGF1 and IGF2]), ... | 18,753,603 |
Determination of pyrophosphorylated forms of lipid A in Gram-negative bacteria using a multivaried mass spectrometric approach. | Lipid A isolated from several bacteria (Escherichia coli, Pseudomonas aeruginosa, Salmonella enterica, and various strains of Yersinia) showed abundant formation of pyrophosphate anions upon ion dissociation. Pyrophosphate [H(3)P(2)O(7)](-) and/or [HP(2)O(6)](-) anions were observed as dominant fragments from diphospho... | 18,753,624 |
Stamped microbattery electrodes based on self-assembled M13 viruses. | The fabrication and spatial positioning of electrodes are becoming central issues in battery technology because of emerging needs for small scale power sources, including those embedded in flexible substrates and textiles. More generally, novel electrode positioning methods could enable the use of nanostructured electr... | 18,753,629 |
Exclusion of polymorphisms in carnosinase genes (CNDP1 and CNDP2) as a cause of diabetic nephropathy in type 1 diabetes: results of large case-control and follow-up studies. | Recently, an association was found between diabetic nephropathy and the D18S880 microsatellite, located in the carnosinase gene (CNDP1) on chromosome 18q. Alleles of this microsatellite encode for a variable number of leucine residues (from four to seven) in the leader peptide of the carnosinase precursor. The frequenc... | 18,753,673 |
Incidence of anterior cruciate ligament injuries among elite ballet and modern dancers: a 5-year prospective study. | Ballet and modern dance are jump-intensive activities, but little is known about the incidence of anterior cruciate ligament (ACL) injuries among dancers. Rigorous jump and balance training has been shown in some prospective studies to significantly reduce ACL injury rates among athletes. Dancers advance to the profess... | 18,753,681 |
Adeno-associated virus-mediated gene transfer in a rabbit vein graft model. | Stenoses of venous grafts represent a major limitation in coronary artery bypass surgery. The use of viral vectors to facilitate over-expression of factors within the graft to promote long-term patency is a promising new therapeutic concept. One of the viral vector systems is the adeno-associated virus (AAV); a non-pat... | 18,753,702 |
[Regional cerebral blood flow patterns in extremely elderly patients with Alzheimer's disease]. | Clinical and pathologic features in Alzheimer's disease (AD) patients differ depending on the age of onset. The aim of our study was to compare the regional cerebral blood flow (rCBF) patterns of younger, elderly, and extremely elderly patients with AD with that of controls to characterize the rCBF patterns in extremel... | 18,753,716 |
Relationship between sleep-disordered breathing level and acute onset time of congestive heart failure. | Sleep-disordered breathing (SDB) is frequently observed in patients with congestive heart failure. Recent studies have shown that SDB negatively affects the onset of congestive heart failure; however, no studies have addressed the relationship between the level of SDB and the onset time of acute dyspnea. We hypothesize... | 18,753,730 |
Effect of having a sense of purpose in life on the risk of death from cardiovascular diseases. | Many studies have focused on disease causality, but few of them deal with health-promoting factors. Thus, we examined the effect of having a sense of purpose in life (ikigai) on mortality from cardiovascular disease (CVD). In 1988, we conducted a prospective cohort study of 2,959 Japanese subjects, ranging in age from ... | 18,753,736 |
Testosterone is a strong correlate of ghrelin levels in men and postmenopausal women. | The secretion and regulation of several hormones such as leptin and growth hormone (GH) is sexually dimorphic. Gender effects on ghrelin, a hormone involved in the regulation of GH secretion and appetite control, are controversial. Our aim was to study the relationship between plasma ghrelin and serum sex steroid hormo... | 18,753,737 |
Bone turnover, osteopenia and vascular calcifications in hemodialysis patients. A histomorphometric and multislice CT study. | Several classical risk factors are at the base of vascular calcifications in hemodialysis patients. Among these, according to a general opinion, also bone turnover plays a role, which, however, requires a better definition. In addition, it has been suggested that there is a relationship between primary osteoporosis and... | 18,753,739 |
Tetracycline-inducible gene expression in conditionally immortalized mouse podocytes. | Conditionally immortalized podocytes are valuable research tools but are difficult to efficiently transfect and do not provide graded transgene expression. Conditionally immortalized mouse podocyte cell lines were established employing a tetracycline-inducible system. Glomerular cells, isolated from transgenic mice bea... | 18,753,740 |
The human genome and its upcoming dynamics. | The mapping, sequencing and analysis of the human genome is a milestone in biomedical research and a fundamental advance in self-knowledge. Because the sequence was intended to serve as a universal and permanent foundation of biomedical research, enormous international efforts were undertaken to reach the highest level... | 18,753,765 |
Cracking the genomic piggy bank: identifying secrets of the pig genome. | Though researchers are uncovering valuable information about the pig genome at unprecedented speed, the porcine genome community is barely scratching the surface as to understanding interactions of the biological code. The pig genetic linkage map has nearly 5,000 loci comprised of genes, microsatellites, and amplified ... | 18,753,772 |
The chicken genome. | The chicken has long been an important model organism for developmental biology, as well as a major source of protein with billions of birds used in meat and egg production each year. Chicken genomics has been transformed in recent years, with the characterisation of large EST collections and most recently with the ass... | 18,753,775 |
Insights from Xenopus genomes. | Amphibians have been used since the 19th century as vertebrate models for the experimentalist. Since 50 years or so, Xenopus laevis is the most widely used anuran amphibian research organism. However, because it is a pseudo-tetraploid species, its genetics has been lagging behind. Contemporary studies shift their focus... | 18,753,776 |
Divergence of regulatory sequences in duplicated fish genes. | Duplicated genes can undergo different fates, from nonfunctionalization to subfunctionalization and neofunctionalization. In particular, changes in regulatory sequences affecting the expression domain of genes seem to be responsible for the latter two fates. In this study we used in silico motif detection to show how a... | 18,753,786 |
[Effects of eye protective device and ear protective device application on sleep disorder with coronary disease patients in CCU]. | The purpose of this research was to analyze the effects of an eye protective device and ear protective device application on sleep disorder with coronary disease patients in CCU. The research design was set up as a nonequivalent control group non-synchronized design. The subjects were coronary disease patients in the C... | 18,753,810 |
Evaluation of serotonin-2A receptor occupancy with 123I-5-I-R91150 and single-photon emission tomography before and after low-dose pipamperone administration in the canine brain. | To conduct a cost-efficient pilot study on the effect of low-dose pipamperone on the serotonin-2A receptor binding in a large animal model with conventional single-photon emission tomography modalities. Three healthy drug-naive female Beagle dogs were scanned before and after administration of a single-dose pipamperone... | 18,753,826 |
Efficacy, safety and tolerability of tipranavir coadministered with ritonavir in HIV-1-infected children and adolescents. | To evaluate the efficacy, safety and tolerability of ritonavir-boosted tipranavir (TPV/r) in HIV-1-infected pediatric patients. Open-label randomized pediatric trial (1182.14/PACTG1051) comparing TPV/r at two doses including an optimized background regimen. HIV-1-infected patients (2-18 years) with plasma viral load 15... | 18,753,862 |
Credentialing and certification: issues for clinical nurse specialists. | This article will provide a brief overview of the concepts of credentialing and certification and will identify some of the issues around certification and credentialing for clinical nurse specialists (CNSs). The article will also describe some of the misconceptions about certification and licensure that cause problems... | 18,753,882 |
Clade-specific HIV-1 integrase polymorphisms do not reduce raltegravir and elvitegravir phenotypic susceptibility. | The contribution of clade-specific polymorphisms in the HIV-1 integrase gene towards integrase inhibitor phenotypic susceptibility was tested on 137 clinical isolates, of which 60 were non-clade B strains. Control Q148R mutant virus showed fold change values of 17.85 +/- 2.77 and 88.94 +/- 9.02 for raltegravir and elvi... | 18,753,927 |
Lack of genetic association between exaggerated placental site reaction and placental site trophoblastic tumor. | Exaggerated placental site (EPS) reaction is a reactive or an exuberant physiologic process involving intermediate trophoblasts infiltrating the underlying endomyometrium at the implantation site. Sharing similar cytological and immunohistochemical features with the tumor cells of placental site trophoblastic tumor, a ... | 18,753,963 |
Structural aberrations affecting the MYC locus indicate a poor prognosis independent of clinical risk factors in diffuse large B-cell lymphomas treated within randomized trials of the German High-Grade Non-Hodgkin's Lymphoma Study Group (DSHNHL). | Recent retrospective studies of heterogeneously treated patients have suggested that chromosomal aberrations of the MYC gene locus indicate an unfavorable prognosis in diffuse large B-cell lymphoma (DLBCL). Here, we investigated the prognostic impact of MYC aberrations analyzed by interphase fluorescence in situ hybrid... | 18,754,028 |
NKG2D ligands expression and NKG2D-mediated NK activity in Sezary patients. | Sezary syndrome (SS) is a rare lymphoma characterized by the clonal expansion in the skin and in blood of CD4(+)CD158k(+) T cells. Natural killer (NK) activation against tumors in leukemia models is partly based on the recognition of the target through the NKG2D/NKG2D ligands interactions. We analyzed ex vivo SS malign... | 18,754,036 |
Macrophage inhibitory cytokine-1 is overexpressed in malignant melanoma and is associated with tumorigenicity. | The incidence of malignant melanoma has increased dramatically over the past four decades. Metastatic melanoma is associated with poor prognosis, as the current treatments do not have a significant impact on prolonging survival or decreasing mortality. We have identified a member of the transforming growth factor-beta ... | 18,754,039 |
Abrogation of the resistance of choline-induced Pseudomonas aeruginosa virulence to sub-MIC erythromycin by ethanol. | Despite Pseudomonas aeruginosa antibiotic resistance, erythromycin (ERM, a macrolide) at subinhibitory concentration (sub-MIC) reduces its pathogenicity. We assessed ERM effects on P. aeruginosa in cultures containing choline (Ch) without and with 1% ethanol (Et) addition. Ch, as an osmoprotectant, increases the follow... | 18,754,042 |
Immunotherapy: a way to improve the therapeutic outcome of photodynamic therapy? | Photodynamic therapy (PDT) is a treatment for cancer and non-cancerous lesions involving light and a sensitizing drug, a so-called photosensitizer. Photosensitizers for PDT usually accumulate in tumour tissues with some selectivity. Thus, malignant and abnormal cells can be destroyed by PDT which acts by producing sing... | 18,754,046 |
Cryopreservation of black chokeberry in vitro shoot apices. | In vitro shoot apices of black chokeberry (Aronia melanocarpa Elliott) were successfully cryopreserved utilizing three methods, namely vitrification, encapsulation-vitrification and encapsulation-dehydration. Encapsulation-dehydration and encapsulation-vitrification, however, seem preferable to vitrification, since the... | 18,754,061 |
Clinically relevant variations of the superior thyroid artery: an anatomic guide for surgical neck dissection. | The superior thyroid artery (STA) is the dominant arterial supply of the thyroid gland, upper larynx and the neck region. The knowledge of variations in possible patterns of origin, courses, and branching pattern of the STA is also important for surgical procedures in the neck region, such as emergency cricothyroidotom... | 18,754,071 |
Massive proteinuria and acute renal failure after oral bisphosphonate (alendronate) administration in a patient with focal segmental glomerulosclerosis. | A 61-year-old Japanese man with nephrotic syndrome due to focal segmental glomerulosclerosis was initially responding well to steroid therapy. The amount of daily urinary protein decreased from 15.6 to 2.8 g. Within 14 days of the oral bisphosphonate (alendronate sodium) administration, the amount of daily urinary prot... | 18,754,075 |
Deactivation kinetics and response surface analysis of the stability of alpha-L-rhamnosidase from Penicillium decumbens. | The stability of the mixed enzyme preparation Naringinase from Penicillium decumbens was studied in dependence of the temperature, the pH value, and the enzyme concentration by means of response surface methodology. Deactivation kinetics by formation of an intermediate state was proposed for fitting deactivation data. ... | 18,754,082 |
Cisplatin-induced gastric dysrhythmia and emesis in dogs and possible role of gastric electrical stimulation. | The aim of this study was to investigate the effect of cisplatin on gastric myoelectrical activity and the role of gastric electrical stimulation in the treatment of cisplatin-induced emesis in dogs. Seven dogs implanted with electrodes on the gastric serosa were used in a two-session study. Cisplatin was infused in bo... | 18,754,094 |
[Cellular mechanisms of tumor response: clinical demands]. | Diseases caused by cancer have become more common due to an increase in life-expectation, but the probability of reaching an old age with or without a tumor disease is still increasing. According to the statistics of the German Cancer register, at present more than half of cancer patients survive for at least 5 years a... | 18,754,097 |
Resistance to Thielaviopsis basicola in the cultivated A genome cotton. | Black root rot (BRR), incited by the soilborne pathogen Thielaviopsis basicola has the potential to cause significant economic loss in cotton (Gossypium spp.) production. Cultivated tetraploids of cotton (G. hirsutum and G. barbadense) are susceptible although resistant types have been identified in a possible tetraplo... | 18,754,098 |
Protective effect of resveratrol in endotoxemia-induced acute phase response in rats. | Lipopolysaccharide (LPS), a glycolipid component of the cell wall of gram-negative bacteria can elicit a systemic inflammatory process leading to septic shock and death. Acute phase response is characterized by fever, leucocytosis, thrombocytopenia, altered metabolic responses and redox balance by inducing excessive re... | 18,754,105 |
Vincristine-induced fatal neuropathy in non-Hodgkin's lymphoma. | The vinca alkaloids are neurotoxic, usually causing a peripheral neuropathy, but cranial neuropathies are rare as side effects. We describe a case of vincristine-induced multiple cranial and autonomic neuropathy, and sensory-motor axonal peripheral neuropathy (pan-neuropathy), which is an extremely rare fatal complicat... | 18,754,106 |
Speculating to accumulate: reducing the cost of wound care by appropriate dressing selection. | The key determinants of wound-care costs are well known. When undertaking local audits, practitioners are advised to collect data against each of these determinants and then use them to formulate cost-effective dressing formularies. | 18,754,198 |
Euthanasia: a summary of the law in England and Wales. | When medical treatment becomes futile, or the patient's suffering is intractable, doctors face the agonising dilemma of whether to proceed with euthanasia. It is important for a doctor to be familiar with the law surrounding euthanasia, in order to avoid prosecution. This paper explores the law in England and Wales reg... | 18,754,203 |
The vulnerable adult in police custody: lessons learned from the case of R v Paul James Aspinall. | This case review highlights some of the problems that vulnerable adults, especially those with a mental disorder as defined in section 1 (2) of the Mental Health Act 1983, face in police custody. These service users already experience some form of discrimination within the wider society in terms of access to community ... | 18,754,204 |
Appeals to the Mental Health Review Tribunal in an ageing population. | The United Kingdom (UK) population is ageing. This change is accompanied by an increase in the number of people aged over 65 who come into contact with psychiatric services. The use of the Mental Health Act 1983 (MHA) in patients above 65 years of age is limited. These patients are less likely to appeal against their d... | 18,754,213 |
Suicide pact by hanging: a case report. | A suicide pact is an agreement between two people to end their lives. The presence of an over-dependent relationship and a threat to the maintenance of closeness are strongly associated with the attempt. We present a case of a suicide pact where a 19-year-old female and a 20-year-old male who were lovers committed suic... | 18,754,217 |
Family history of cardiovascular disease as a risk factor for coronary artery disease in adult offspring. | There is controversy about the role of positive family history as an independent risk factor for coronary artery disease. The aim of this work was to investigate the influence of family history on presentation of coronary artery disease in adult offspring, and on its severity. In a retrospective cross-sectional study a... | 18,754,276 |
Maternal serum mannose-binding lectin in severe preeclampsia. | We aimed to investigate the level of serum mannose-binding lectin (MBL) in severe preeclamptic patients, women with uncomplicated pregnancies, and healthy reproductive-age females and its impact on gestational age at delivery and birth weight. Serum MBL levels were measured in 27 severe preeclampsia patients (Group 1),... | 18,754,287 |
Mid-trimester maternal serum AFP levels in predicting adverse pregnancy outcome. | In this prospective study, we investigated the association between mid-trimester maternal serum alpha-fetoprotein AFP (MSAFP) levels and adverse pregnancy outcome in a South-Western Greek population. 110 healthy Greek women with spontaneous pregnancies, investigated for MSAFP levels between the 13th and 24th week of ge... | 18,754,295 |
Placenta percreta presenting in the first trimester and resulting in severe consumption coagulopathy and hysterectomy: a case report. | Placenta percreta complicating pregnancy in the first trimester is extremely rare, and only a few cases have been reported in the literature. A patient with risk factors for placenta percreta that presented as first trimester fetal demise, unresponsive to medical management with prostaglandin, is presented. The patient... | 18,754,300 |
Successful treatment of advanced endometriosis with extremely high CA 125 and moderately elevated CA 15-3 levels. | We present the case of a patient with advanced endometriosis who presented with chronic pelvic pain, bilateral unruptured ovarian endometrioma, massive peritoneal implants and extremely elevated CA 125, and also elevated CA 15-3 levels. Laparoscopy revealed bilateral unruptured ovarian endometrioma and diffuse peritone... | 18,754,302 |
The selection and use of essential medicines. | This report presents the recommendations of the Subcommittee of the WHO Expert Committee responsible for the WHO Model List of Essential Medicines. The task of this Subcommittee was to draw up the first WHO Model List of Essential Medicines for Children. The first part of the report contains a summary of the Committee'... | 18,754,303 |
[Arguments against implementing a population-based screening programme for colorectal cancer]. | Screening healthy people at low risk of colorectal cancer using faecal occult blood testing (FOBT) is an old method that was proven effective in reducing colorectal cancer mortality in randomised controlled trials published in 1993-1996. Screening reduced colorectal cancer mortality by 1 per 10,000 person-years and inc... | 18,754,310 |
[Transfusion-related acute lung injury (TRALI) in the Netherlands in 2002-2005]. | To determine the number of reported cases of transfusion-related acute lung injury (TRALI) in the Netherlands in 2002-2005 and to determine how many cases were associated with incompatibility between leukocyte-reactive antibodies in the donor plasma and leukocytes or antigens in the recipient. Retrospective national ca... | 18,754,313 |
Analysis of children with Chlamydophila (Chlamydia) pneumoniae and Mycoplasma pneumoniae respiratoryinfections by real-time PCR assay and serological tests. | We examined 73 children with respiratory infections for Chlamydophila (Chlamydia) pneumoniae and Mycoplasma pneumoniae using real-time PCR assay and serological tests. C. pneumoniae and M. pneumoniae infections were found in 11 (15.1%) and 6 (8.2%) cases, respectively. The sensitivities and specificities of real-time P... | 18,754,321 |
Evolution of human immunodeficiency virus type 1 serotypes in northern Tanzania: a retrospective study. | The HIV-1 epidemic in Tanzania is characterized by the circulation of heterogeneous virus subtypes. A retrospective study was conducted to determine the changing pattern of circulating HIV-1 subtypes in northern Tanzania. A peptide-binding enzyme immunoassay (PEIA) was employed to analyse 305 HIV-1 positive serum and p... | 18,754,325 |
Indoor levels of polycyclic aromatic hydrocarbons in homes with or without wood burning for heating. | The aim of this study was to investigate the impact of domestic wood burning on indoor levels of polycyclic aromatic hydrocarbons (PAHs). Indoor and outdoor concentrations of 27 PAHs were measured during wintertime in homes with (n= 13) or without (n 0) wood-burning appliances and at an ambient site in a Swedish reside... | 18,754,350 |
Catalytic wet air oxidation of aniline with nanocasted Mn-Ce-oxide catalyst. | The catalytic wet air oxidation of aqueous solution containing 1000 ppm aniline was conducted in a trickle-bed reactor packed with a novel nanocasted Mn-Ce-oxide catalyst (surface area of 300 m2/g) prepared using SBA-15 silica as a hard template. A range of liquid hourly space velocities (5-20 h(-1)) and temperatures (... | 18,754,364 |
Laboratory measurements of the heterogeneous oxidation of condensed-phase organic molecular makers for meat cooking emissions. | Multiphase oxidation of trace organic constituents inside of complex atmospheric particles is not well understood. In this study, organic aerosol formed from flash-vaporized residual grease from meat cooking was exposed to atmospherically relevant ozone concentrations in a smog chamber for 4-6 h. Changes in particle co... | 18,754,366 |
Atmospheric transport and outflow of polycyclic aromatic hydrocarbons from China. | A potential receptor influence function (PRIF) model, based on air mass forward trajectory calculations, was applied to simulate the atmospheric transport and outflow of polycyclic aromatic hydrocarbons (PAHs) emitted from China. With a 10 day atmospheric transport time, most neighboring countries and regions, as well ... | 18,754,369 |
Quantitative structure-property relationships for predicting metal binding by organic ligands. | Quantitative structure-property relationships (QSPRs) are developed to predict the complexation of Al(III), Ca(II), Cd(II), Cu(II), Ni(II), Pb(II), and Zn(II) by organic ligands containing carboxylate, phenol, amine, ether, and alcoholfunctional groups. These QSPRs predict conditional stability constants (K(M') at pH 7... | 18,754,371 |
Quantification of functional groups and modeling of their ionization behavior in the active layer of FT30 reverse osmosis membrane. | A new experimental approach was developed to measure the concentration of charged functional groups (FGs) in the active layer of thin-film composite reverse osmosis (RO) and nanofiltration (NF) membranes as a function of solution pH. FT30 RO membrane, with a fully aromatic polyamide (PA) active layer sandwiched between... | 18,754,378 |
Transformation of oxidation products and reduction of estrogenic activity of 17beta-estradiol by a heterogeneous photo-Fenton reaction. | A novel photo-Fenton catalyst, alpha-FeOOH loaded resin (alpha-FeOO HR), was synthesized and evaluated through transformation of a steroidal endocrine disrupting compounds (EDC), 17beta-estradiol (E2), under weak UV irradiation in the presence of H2O2. E2 photodegradation intermediates elucidated in detail by GC/MS and... | 18,754,381 |
Development of silica/vanadia/titania catalysts for removal of elemental mercury from coal-combustion flue gas. | SiO2/V2O5/TiO2 catalysts were synthesized for removing elemental mercury (Hg0) from simulated coal-combustion flue gas. Experiments were carried out in fixed-bed reactors using both pellet and powder catalysts. In contrast to the SiO2-TiO2 composites developed in previous studies, the V2O5 based catalysts do not need u... | 18,754,385 |
Bleedings, purges, and vomits: Dr. Benjamin Rush's republican medicine, the bilious remitting yellow-fever epidemic of 1793, and the non-origin of the law of informed consent. | To the consternation of many physicians, the modern law of informed consent imposes certain constraints on their actions, not least that they respect patients' decisions to redefine at will the scope of care. The consequences of this transfer of power are often a nuisance and occasionally fatal, but always a reflection... | 18,754,398 |
[Endothelial function assessment by positron emission tomography in patients with hypercholesterolemia]. | Hypercholesterolemia prompts to endothelial dysfunction (ED) and ED predisposes to atherogenesis. ED appears early in the course of atherogenesis and it is considered a coronary artery disease (CAD) marker. To assess endothelial function (EF) using Positron Emission Tomography (PET) in asymptomatic patients with recent... | 18,754,405 |
[Accuracy of 64 slice computed tomography angiography in the diagnosis of ischemic coronary artery disease]. | Multislice computed tomography coronary angiography (MSCT-CA) has been developed in the last years. One of the advantages is to supply information of the lumen and wall of the vessels. The aim was to assess the diagnostic accuracy of MSCT - CA to detect significant coronary stenoses taking as gold standard the invasive... | 18,754,407 |
[Medical image retrieval based on low level feature fusion and relevance feedback]. | Based on chest images' features, this paper presents a retrieval method with domination color of partition, gray level co-occurrence matrix and gradient image shape invariant moments, as well as the fusion of them and the technique of relevance feedback. In Windows Vista environment with Visual C + +, a chest image ret... | 18,754,416 |
[Multi-points pulse information acquisition and 3-D reconstruction based on grid-net images]. | A method of acquiring radial pulse information from the grid-net area on every pulse image frame is proposed based on the principle of lens imaging and the characteristics of image data. The radial pulse image data are collected by the pulse image sensor. Multi-points out-of-plane displacements of the pulse are acquire... | 18,754,418 |
[Design of a flyback switch mode power supply for multichannel electrophysiological stimulators]. | In order to supply the multichannel electrical stimulator, a DC-DC flyback switch mode power supply based on a high-performance current mode controller UC3845 has been designed. The experimental results indicate that the power supply has satisfied the demands and can supply the multichannel electrical stimulator and si... | 18,754,421 |
[Identification of two potential serum biomarkers for ovarian cancer and clinical validation thereof]. | To identify practical biomarkers used in diagnosis of ovarian cancer. Peripheral blood samples were collected from 59 ovarian cancer patients, 64 ovarian benign tumors patients, and 142 healthy women and underwent column chromatography to purify the target proteins. The proteins thus obtained were identified with matri... | 18,754,431 |
Occurrence of zearalenone on Fusarium graminearum infected wheat and maize fields in crop organs, soil, and drainage water. | The mycotoxin zearalenone (ZON) is a very potent natural endocrine disrupting chemical, produced by Fusarium graminearum fungi growing on crops such as wheat and maize. Although it is well-investigated in food and feed, very little is known about its environmental fate and behavior. Here, we report the occurrence of ZO... | 18,754,460 |
Detailed characterization and profiles of crankcase and diesel particulate matter exhaust emissions using speciated organics. | A monitoring campaign was conducted in August-September 2005 to compare different experimental approaches quantifying school bus self-pollution. As part of this monitoring campaign, a detailed characterization of PM2.5 diesel engine emissions from the tailpipe and crankcase emissions from the road draft tubes was perfo... | 18,754,490 |
Permanganate oxidation of sulfur compounds to prevent poisoning of Pd catalysts in water treatment processes. | The practical application of Pd-catalyzed water treatment processes is impeded by catalyst poisoning by reduced sulfur compounds (RSCs). In this study, the potential of permanganate as a selective oxidant for the removal of microbially generated RSCs in water and as a regeneration agent for S-poisoned catalysts was eva... | 18,754,501 |
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