title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Hyperosmotic stress contributes to mouse colonic inflammation through the methylation of protein phosphatase 2A. | There are several reports suggesting hyperosmotic contents in the feces of patients suffering from inflammatory bowel disease (IBD). Previous works have documented that hyperosmolarity can cause inflammation attributable to methylation of the catalytic subunit of protein phosphatase 2A (PP2A) and subsequent NF-kappaB a... | 18,755,808 |
Effects of quetiapine, risperidone, 9-hydroxyrisperidone and ziprasidone on the survival of human neuronal and immune cells in vitro. | Because there are reports on cytotoxic and cytoprotective effects of antipsychotics, the aim of the present study was to evaluate the impacts of different concentrations (1.6-50 microg/mL) of atypical antipsychotics on the survival of human neuronal (neuroblastoma SH-SY5Y) and immune (monocytic U-937) cells and on ener... | 18,755,815 |
Association of killer cell immunoglobulin-like receptor genotypes with vascular arterial events and anticardiolipin antibodies in patients with lupus. | To determine whether killer cell immunologlobulin-like receptor (KIR) genotypes are associated with vasculitis, vascular arterial events or anticardiolipin (aCL) antibodies in patients with lupus. A total of 304 patients followed prospectively at the University of Toronto Lupus Clinic were assessed for the occurrence o... | 18,755,860 |
A proteomic study of peripheral blood mononuclear cells in systemic lupus erythematosus. | Our objective was to analyze the changes in the protein expression profiles of peripheral blood mononuclear cells (PBMCs) in patients with systemic lupus erythematosus (SLE). Peripheral blood was obtained from patients with SLE and healthy controls. 2-D gel electrophoresis was performed, and gels were silver-stained. D... | 18,755,861 |
Cross-regulatory protein-protein interactions between Hox and Pax transcription factors. | Homeotic Hox selector genes encode highly conserved transcriptional regulators involved in the differentiation of multicellular organisms. Ectopic expression of the Antennapedia (ANTP) homeodomain protein in Drosophila imaginal discs induces distinct phenotypes, including an antenna-to-leg transformation and eye reduct... | 18,755,899 |
Independent effect of depression and anxiety on chronic obstructive pulmonary disease exacerbations and hospitalizations. | Depression and anxiety are significant comorbid and potentially modifiable conditions in chronic obstructive pulmonary disease (COPD), but their effects on exacerbations are not clear. To investigate the independent effect of depression and anxiety on the risk of COPD exacerbations and hospitalizations. A multicenter p... | 18,755,925 |
Natural selection on a major armor gene in threespine stickleback. | Experimental estimates of the effects of selection on genes determining adaptive traits add to our understanding of the mechanisms of evolution. We measured selection on genotypes of the Ectodysplasin locus, which underlie differences in lateral plates in threespine stickleback fish. A derived allele (low) causing redu... | 18,755,942 |
Cavity optomechanics: back-action at the mesoscale. | The coupling of optical and mechanical degrees of freedom is the underlying principle of many techniques to measure mechanical displacement, from macroscale gravitational wave detectors to microscale cantilevers used in scanning probe microscopy. Recent experiments have reached a regime where the back-action of photons... | 18,755,966 |
Polarized gamma-ray emission from the crab. | Pulsar systems accelerate particles to immense energies. The detailed functioning of these engines is still poorly understood, but polarization measurements of high-energy radiation may allow us to locate where the particles are accelerated. We have detected polarized gamma rays from the vicinity of the Crab pulsar usi... | 18,755,970 |
The biologic properties of leukemias arising from BCR/ABL-mediated transformation vary as a function of developmental origin and activity of the p19ARF gene. | Recent reports have shown that upon expression of appropriate oncogenes, both stem cells and more differentiated progenitor populations can serve as leukemia-initiating cells. These studies suggest that oncogenic mutations subvert normal development and induce reacquisition of stem-like features. However, no study has ... | 18,755,985 |
Use of clinical decision support to increase influenza vaccination: multi-year evolution of the system. | Despite recognition that clinical decision support (CDS) can improve patient care, there has been poor penetration of this technology into healthcare settings. We used CDS to increase inpatient influenza vaccination during implementation of an electronic medical record, in which pharmacy and nursing transactions increa... | 18,756,001 |
Cardiovascular dynamics in healthy subjects with differing heart rate responses to tilt. | Orthostatic stress such as head-up tilt (HUT) elicits a wide range of heart rate (HR) and arterial pressure (AP) responses among healthy individuals. In this study, we evaluated cardiovascular dynamics in healthy subjects with different HR responses to HUT, but without autonomic dysfunction. We measured AP (brachial ar... | 18,756,006 |
Vitamin D from dietary intake and sunlight exposure and the risk of hormone-receptor-defined breast cancer. | Evidence has emerged for a role of vitamin D in the development of breast cancer, and there is some suggestion that its antiproliferative effect is greater in hormone-receptor-positive cells. Few epidemiologic studies have considered the association between vitamin D and hormone-receptor-defined breast cancer, and the ... | 18,756,015 |
Body weight and plasma levels of ghrelin and leptin during treatment with olanzapine. | Although enhanced appetite and weight gain are potential side effects of treatment with antipsychotic agents, particularly olanzapine and clozapine, the mechanisms underlying these side effects are poorly understood. Leptin and ghrelin were recently identified as hormones that play crucial roles in the regulation of en... | 18,756,058 |
Benign schwannoma of the liver: a case report. | A primary benign schwannoma of the liver is extremely rare. Only nine cases have been reported in the medical literature worldwide and no case has been reported in Korea previously. A 36-yr-old woman was admitted to our hospital with vague epigastric pain. The ultrasound and computed tomography scan revealed a multi-se... | 18,756,066 |
The rice genome structure as a trail from the past to beyond. | Rice is the first cultivated plant species to be completely sequenced. Cultivation, in general, is a major factor that contributes to selection pressure of a target species resulting in accelerated changes in genome structure from an original wild species. The genome sequence of cultivated rice can now be used as a sta... | 18,756,083 |
Heterologous expression and characterization of glycogen branching enzyme from Synechocystis sp. PCC6803. | A gene (sll0158) putatively encoding a glycogen branching enzyme (GBE, E.C. 2.4.1.18) was cloned from Synechocystis sp. PCC6803, and the recombinant protein expressed and characterized. The PCR-amplified putative GBE gene was ligated into a pET-21a plasmid vector harboring a T7 promoter, and the recombinant DNA transfo... | 18,756,098 |
Estimation of cardiovascular risk: a comparison between the Framingham and the SCORE model in people under 60 years of age. | The Framingham Heart Study risk model has been used in the majority of cardiovascular risk management guidelines. Recently, a new model based on the SCORE system has been proposed. We compared both risk models with regard to their ability to predict cardiovascular mortality in the Netherlands. Cohort study. In a Dutch ... | 18,756,178 |
Quantum dots versus organic dyes as fluorescent labels. | Suitable labels are at the core of Luminescence and fluorescence imaging and sensing. One of the most exciting, yet also controversial, advances in label technology is the emerging development of quantum dots (QDs)--inorganic nanocrystals with unique optical and chemical properties but complicated surface chemistry--as... | 18,756,197 |
Increases in weight and body size increase the odds for hypertension during 7 years of follow-up. | Changes in BMI and body size were compared to incident hypertension in 24,550 men and 10,111 women followed prospectively as part of the National Runners' Health Study to test whether long-term weight change affects hypertension risk. Incident hypertensions were reported by 2,143 men and 430 women during (mean +/- s.d.... | 18,756,262 |
Replication licensing and cancer--a fatal entanglement? | Correct regulation of the replication licensing system ensures that chromosomal DNA is precisely duplicated in each cell division cycle. Licensing proteins are inappropriately expressed at an early stage of tumorigenesis in a wide variety of cancers. Here we discuss evidence that misregulation of replication licensing ... | 18,756,287 |
Conjugated linoleic acid and atherosclerosis: studies in animal models. | Conjugated linoleic acids (CLA) are isomeric forms of linoleic acid (LA) containing two conjugated sites of unsaturation. The most abundant dietary form of CLA is the cis-9,trans-11 (c-9,t-11) isomer that is found in the fatty tissues and milk of ruminant animals. CLA can also be acquired by ingestion of supplements, w... | 18,756,324 |
Cardiovascular outcomes in the comparative hypertension drug trials: more consensus than controversy. | The comparative anti-hypertensive drug trials conducted to assess their cardiovascular protective efficacy actually produce compatible, not conflicting, results. In the last decade, there were 13 major comparative hypertension drug trials with the cardiovascular primary outcome being statistically equivalent in 11 of t... | 18,756,340 |
The alteration of plasma's zinc and copper levels in patients with burn injuries and the relationship to the time after burn injuries. | Burn injury is a medical problem as well as a social burden on the national health services in developing countries. Trace elements have important roles in wound healing and act as antioxidants. In this study, zinc (Zn) and copper (Cu) levels in plasma of burned patients and their relationship with the burn surface are... | 18,756,346 |
Static and moving phantom studies for radiation treatment planning in a positron emission tomography and computed tomography (PET/CT) system. | To determine an appropriate threshold value for delineation of the target in positron emission tomography (PET) and to investigate whether PET can delineate an internal target volume (ITV), a series of phantom studies were performed. An ellipse phantom (background) was filled with 1028 Bq/ml of [(18)F] fluoro-2-deoxygl... | 18,756,360 |
The clinical efficacy of (18)F-FDG-PET/CT in benign and malignant musculoskeletal tumors. | Most of the current clinical data on the role of 2-[(18)F]fluoro-2-deoxy-D -glucose positron emission tomography ((18)F-FDG-PET) in musculoskeletal tumors come from patients studied with PET and less frequently with hardware fusion PET/computed tomography (CT). And the number of cases in each report is too small to cla... | 18,756,363 |
Detection of a suspected bronchobiliary fistula by hepatobiliary scintigraphy. | Bronchobiliary fistula (BBF) represents a rare but severe complication in patients affected by liver metastases. Although a clinical suspicion can arise when specific clinical signs, in particular biliptysis, are present, conventional imaging modalities often fail to confirm the diagnosis. We present a case of a patien... | 18,756,368 |
Conscientious refusal by physicians and pharmacists: who is obligated to do what, and why? | Some medical services have long generated deep moral controversy within the medical profession as well as in broader society and have led to conscientious refusals by some physicians to provide those services to their patients. More recently, pharmacists in a number of states have refused on grounds of conscience to fi... | 18,756,375 |
Elekta Precise Table characteristics of IGRT remote table positioning. | Cone beam CT is a powerful tool to ensure an optimum patient positioning in radiotherapy. When cone beam CT scan of a patient is acquired, scan data of the patient are compared and evaluated against a reference image set and patient position offset is calculated. Via the linac control system, the patient is moved to co... | 18,756,401 |
Tranilast: a pharmaceutical candidate for reduction of adhesions using a novel approach. | Postsurgical adhesion formation has numerous deleterious side effects in a wide variety of surgical settings. Physical barriers used together with laparoscopy were developed in hopes of reducing the tissue trauma seen with open procedures and separating tissues during the critical time of healing to reduce adhesion for... | 18,756,411 |
The concept of endophenotypes in psychiatric diseases meeting the expectations? | Although the prominent role of genetics in psychiatric diseases has been established in various family, twin and adoption studies over the last decades, the identification of concrete contributing genes has been demanding. The reasons for this are manifold, including inconsistencies in psychiatric classification system... | 18,756,419 |
[Efficacy of pegylated interferon alpha-2a and ribavirin treatment in chronic hepatitis C patients depends on various baseline parameters and early viral kinetics]. | The aim of the study was to compare efficacy and viral kinetics during antiviral treatment in different chronic hepatitis C patients--naïve, relapsers and non-responders to previous pegylated interferon alpha (PEG-IFN) and ribavirin treatment, with different genotypes, baseline viremia, body weight, age and gender--and... | 18,756,436 |
Manganese-enhanced MRI of acute cardiac ischemia and chronic infarction in pig hearts: kinetic analysis of enhancement development. | To assess infarction development in pig hearts, Mn-enhanced and Gd-enhanced MRI were used. In domestic pigs (25-35 kg, n = 37), the first and second diagonal branches of the left anterior descending coronary artery were ligated to induce acute ischemia and infarction (ischemia+reperfusion) or chronic infarction of incr... | 18,756,440 |
Distinctions between fetal and adult human platelet-derived growth factor-responsive neural precursors. | Platelet-derived growth factor (PDGF)-responsive neural precursors (PRPs; also known as oligodendrocyte progenitor cells) are one of the best characterized precursor cell populations of the rodent central nervous system. Yet little is known about the biology of human PRPs because of an apparent inability to culture and... | 18,756,507 |
HIV-associated plasmablastic lymphoma: lessons learned from 112 published cases. | Plasmablastic lymphoma (PBL) is a distinct subtype of non-Hodgkin B-cell lymphoma, originally described with a strong predilection to the oral cavity of human immunodeficiency virus (HIV)-infected individuals. Data regarding patient age and gender, HIV status, initiation of and response to highly active antiretroviral ... | 18,756,521 |
Discovery of water-soluble antioxidant flavonols without vasorelaxant activity. | 3',4'-Dihydroxyflavonol (DiOHF) is a cardioprotective flavonol that can decrease ischaemia/reperfusion injury in the heart. DiOHF exhibits antioxidant and vasorelaxant properties that are thought to underlie its cardioprotective activity. A major limitation to its use for the treatment or prevention of cardiovascular d... | 18,756,557 |
No indications of cognitive side-effects in a prospective study of breast cancer patients receiving adjuvant chemotherapy. | A number of cross-sectional studies have reported reduced cognitive function in cancer patients receiving chemotherapy compared with other cancer patients and healthy controls, suggesting that chemotherapy could be associated with cognitive side-effects. Recently published prospective studies question this hypothesis, ... | 18,756,583 |
OCTN and CARD15 gene polymorphism in Chinese patients with inflammatory bowel disease. | To investigate the single nucleotide polymorphism (SNPs) distribution of NOD2/CARD15 (R702W, G908R), OCTN1 1672C/T and OCTN2-207G/C in Chinese patients with inflammatory bowel disease (IBD). A total of 61 patients with Crohn's disease (CD), 151 patients with ulcerative colitis (UC), and 200 unrelated healthy controls w... | 18,756,601 |
Compression anastomosis clip for gastrointestinal anastomosis. | To investigate the feasibility of compression anastomosis clip (CAC) for gastrointestinal anastomosis proximal to the ileocecal junction. Sixty-six patients undergoing gastrointestinal anastomosis proximal to the ileocecal junction were randomized into two groups according to the anastomotic method, CAC or stapler. The... | 18,756,603 |
Laparoscopic resection for incidentally detected Meckel diverticulum. | The management of Meckel diverticulum found unexpectedly during an abdominal operation remains controversial. Most published reports have included only patients undergoing diverticulectomy or bowel resection through laparotomy. We report a case of a carcinoid tumor in a Meckel's diverticulum which was incidentally dete... | 18,756,607 |
Primary malignant melanoma of the liver: a case report. | Primary malignant melanoma of the liver is an exceedingly rare tumor. Only 12 cases have been reported in the worldwide literature. We present a case of isolated malignant melanoma of the liver occurring in a 36-year-old Chinese male patient. Comprehensive dermatologic and ophthalmologic examinations revealed no eviden... | 18,756,609 |
The use of therapeutic hypothermia after cardiopulmonary arrest. | Actually recommended by the International Liaison Committee on Resuscitation (ILCOR), therapeutic hypothermia has been the only modality shown to improve neurological outcomes after cardiac arrest. This article provides the background for such recommendations as well as: pathophysiology, review of brain injury during c... | 18,756,644 |
Can etomidate have antiarrhythmic properties? | Etomidate is a drug commonly used for Rapid Sequence Intubation (RSI) and Procedural Sedation Anesthesia (PSA) in the Emergency Department because of its rapid onset of action and low cardiovascular risk profile. The antiarrhythmic effects of etomidate are presented in a patient with unstable wide complex tachycardia, ... | 18,756,645 |
Predictive role of the lambda ratio in the evaluation of metal-on-metal total hip replacement. | The wear of metal-on-metal bearings is affected by various design parameters, such as the clearance or surface roughness. It would be very useful to have a significant indicator of wear according to these design parameters, such as the lambda ratio. Three different batches of cast high- and low-carbon cobalt-chromium h... | 18,756,681 |
Dynamic simulation of a displacement-controlled total knee replacement wear tester. | This paper presents a dynamic finite element method (FEM) model of a commercial displacement-controlled total knee replacement (TKR) wear tester. The first goal of the study was to validate the model, which included both the wear tester and the TKR components. Convergence simulations and experimental testing were perfo... | 18,756,686 |
[Hyper- and hypoaldosteronism]. | The literature review devoted to pathogenesis of the development of hyper- and hypoaldosteronism is presented. Based on the analysis of Russian and English-written literature known and clinically significant diseases arising due to hyper- and hypoaldosteronism are presented. Pathogenetic mechanisms inducing the develop... | 18,756,739 |
[Study of ethno-racial and sexual specificity of hard palate mucosa for person identification]. | Relief of hard palatal mucosa was examined to identify ethno-racial and gender affiliation in representatives of europeoid, mongolid, and intermediate racial groups, viz Estonians (northern europeoid type), Azerbajaninans (southern europeoid), Koreans (Far East mongoloid), and Kasakhs (intermediate). The results of the... | 18,756,758 |
[Medical geography in study of rickettsioses]. | Shorts resume of medical-geographical studies of Q-fever, tsutsugamushi fever, rickettsioses of tick-borne spotted fever is represented. Influence of biotic and abiotic factors on spread and landscape tropism of infection agents is considered. Types of focuses on endemic territories are determined, regions with high ri... | 18,756,781 |
[Scientific collaboration of Russia and France in the study of ricketsioses]. | The description of emerging diseases unknown for the scientists before 90th has begun by the cooperative description of Astrakhan spotted fever by Irina Tarasevich and Didier Raoult. Molecular methods gave the possibility to distinguish its etiological agent from other rickettsiae and to prove that it differs from all ... | 18,756,786 |
[Effect of fluorinated silicone oil on the rabbit retinal antioxidant status]. | The high-grade fluorinated silicone oil made in Russia was tested for its effect on the rabbit retinal antioxidant status. Experiments were made on 36 rabbits (72 eyes) undergoing replacement of the excised vitreous body with sterile 0.9 NaCl solution or with one of the study implants (fluorinated silicon oil, silicon ... | 18,756,801 |
[Epidemic strains influenza viruses A and B in the 2005-2006 season in Russia]. | Investigations indicated that the epidemic upsurge of influenza morbidity in the 2005-2006 season in Russia was caused by the active circulation of influenza viruses A and B. The Center for Ecology and Epidemiology of Influenza, D. I. Ivanovsky Institute of Virology, Russian Academy of Medical Sciences, studied 182 epi... | 18,756,810 |
[Production of human recombinant beta-interferon in the avian cell culture]. | The avian recombinant adenovirus of serotype 1 (CELO) was obtained. The recombinant adenovirus of serotype 1 (CELO) induces expression of human beta-interferon (IB). The expression cassette containing IB gene was placed at the right end of the CELO genome under control of hybrid promoter hEF-1alpha/HTLV. The resulting ... | 18,756,823 |
[Serum levels of ghrelin and leptin in women with polycystic ovary syndrome]. | To compare ghrelin and leptin levels in women with PCOS and healthy subjects and to evaluate the relationship between them and the heterogeneity of clinical and biochemical manifestations of women with polycystic ovary syndrome (PCOS). 45 women with PCOS and 20 controls were included in the study. Serum levels of ghrel... | 18,756,827 |
Identifying serious causes of back pain: cancer, infection, fracture. | Most patients with back pain have a benign condition, but tumors, infections, and fractures must be considered during an initial evaluation because overlooking them can have serious consequences. This article discusses the presentation and diagnostic strategies of these serious causes of back pain. | 18,756,836 |
Adherence to highly active antiretroviral therapy (HAAT) at a Federal Medical Centre. | Highly active antiretroviral therapy (HAART) has proved effective in prolonging survival and improving the quality of life of the people living with HIV/AIDS (PLWHA). For the successful treatment of HIV infection, at least 95% adherence to HAART is required. This study sought to assess adherence to HAART and to identif... | 18,756,852 |
Anxiolytic and sedative effects of extracts of Hibiscus sabdariffa Linn (family Malvaceae). | Aqueous (A), hydroalcoholic (AE) and ethanolic (E) extracts and fractions of dried calyxes of Hibiscus sabdariffa were evaluated for anxiolytic property using elevated-plus maze (EPM), and sedative properties using ketamine-induced sleep in animal models. The extracts exhibited a dose-dependent increase in the time spe... | 18,756,855 |
Accidental displacement of mandibular third molar into soft tissue: a case report. | A case of accidental displacement of a mandibular molar tooth into adjacent submandibular space during routine extraction by a general practitioner is reported. The localization and surgical retrieval of the displaced tooth is described, post-operative period was uneventful and salient lessons for the practitioners hig... | 18,756,859 |
Cell apoptosis as assessed by M30 expression in keratoacanthoma and squamous cell carcinoma. | Involution displayed by keratoacanthoma (KA) represents an important difference between KA and squamous cell carcinoma (SCC). It has been suggested that apoptosis plays a part in process of involution of KA. Altogether 150 specimens were included in this study, 30 cases of each; normal skin (NS), proliferative (pKA) an... | 18,756,900 |
Prognostic significance of BsALP in healing of long bone fractures. | The aim of this work was to assess the relationship of both total alkaline phosphatase (ALP) and bone-specific alkaline phosphatase (BsALP) with the course and outcome of operatively treated long-bone fractures. The activity of total ALP and BsALP was measured in 41 patients with a long bone fracture, comprising 26 men... | 18,756,909 |
A case study of Chinese bound feet: application of footprint analysis. | Foot print patterns of the bound feet of a 90-year-old Chinese female were made to obtain insight into the ergonomic consequences of a Chinese custom that caused significant disabilities for many women throughout history. Pressure patterns were evaluated using the techniques applied to standard thumb print analsyis. A ... | 18,756,921 |
[Injection of activated carbon nanoparticles for guiding lymphadenectomy during minimal invasive surgery in lung cancer]. | To evaluate the clinical value of activated carbon nanoparticles for guiding lymphadenectomy in lung cancer. Fourty-two lung cancer patients were divided into two groups: the control group (22 cases) and experiment group (20 cases) who received activated carbon nanoparticles injection around the tumor either by endosco... | 18,756,943 |
[A comparison of localization by ductoscopy-guided wire and conventional methods in terminal duct excision for women with pathological nipple discharge]. | To evaluate and compare localization by ductoscopy-guided wire with localization by conventional methods in the terminal duct excision for women with pathological nipple discharge. Breast terminal duct excision were performed in 174 consecutive patients with intraductal lesions diagnosed by mammary ductoscopy. Sixty-ei... | 18,756,945 |
[Feasibility of establishment of rat model of bone cancer pain by using Walker 256 cells cultured in vitro or in vivo]. | To investigate the possibility of establishing rat model of bone cancer pain using cancer cells cultured in vitro or by ascites passaging and verify the reliability of this method. Syngeneic SD rat carcinoma cells of the line Walker 256 were cultured in vitro and inoculated into the peritoneal cavity of SD rats respect... | 18,756,951 |
[Trans-sacroiliac joint with plate via the anterior approach in management of posterior pelvic injuries]. | To report the clinical experience in trans-sacroiliac joint with plate via the anterior approach in management of posterior pelvic injuries. The clinical data of 29 cases (30 sides) with pelvic injury, 16 being of type B, and 13 of type C according to the Tile classification; with the average displacement of the poster... | 18,756,955 |
[Diagnostic value of protein tyrosine phosphatase-2beta antibody (IA-2betaA) in type 1 diabetes]. | To explore the prevalence and clinical features of protein tyrosine phosphatase-2beta antibody (IA-2betaA) in type 1 diabetes (T1DM). Four hundred and one T1DM patients and 200 healthy controls were screened for glutamic acid carboxylase antibody (GADA), islet cell antigen-2 (IA-2A), IA-2betaA by radioligand assay. The... | 18,756,962 |
[A clinical trial of using antiplatelet therapy to prevent restenosis following peripheral artery angioplasty and stenting]. | To evaluate the clinical effect and restenosis rate of antiplatelet therapy following peripheral artery angioplasty and stenting. After successful placement of peripheral artery stents to 103 patients with peripheral arterial occlusive disease (PAOD) in were randomized assigned to 2 groups: antiplatelet therapy group r... | 18,756,983 |
[The effect of a strategy to improve adherence of irregular non UE citizens to tuberculosis screening in a clinic of Reggio Emilia]. | Latent tubercolar infection in irregular non EU-citizens in Italy is an important issue of public health. Aim of this paper is to describe the effects of a new organization of the Centre for the health of foreign families of Reggio Emilia. A dedicated nurse, responsible of patients' screening and follow-up, in strict c... | 18,757,002 |
[Sterility in drained serums; before their use in emergency wards and in non-hospital emergency use]. | The authors detail the characteristics for the sterility of drained serums placed in a mobile emergency service unit and they determine how much time they can maintain optimum conditions for the use of these serums by means of a controlled, random, triple blind clinical test in which the units studied were serums prepa... | 18,757,014 |
Phosphorylation of yellow fever virus NS5 alters methyltransferase activity. | Serine/threonine phosphorylation of the nonstructural protein 5 (NS5) is conserved feature of flaviviruses, but the kinase(s) responsible and function(s) remain unknown. Mass spectrometry was used to characterize phosphorylated residues of yellow fever virus (YFV) NS5 expressed in mammalian cells. Multiple different ph... | 18,757,072 |
The Acheulean massive scrapers of Gesher Benot Ya'aqov-a product of the biface chaîne opératoire. | The presence of large scrapers has been reported from Acheulean sites worldwide but they are rarely described in detail. At Gesher Benot Ya'aqov (GBY), a similar group of artifacts, named here "massive scrapers," was identified as a significant component of the lithic assemblage. In this paper, we define and describe t... | 18,757,076 |
Children's pre-operative tonsillectomy pain education: clinical outcomes. | To examine the effects of pre-operative tonsillectomy pain education on children's (7-13 years) self-reported pre-operative anxiety and post-operative clinical outcomes (i.e., anxiety, pain intensity, quality of pain and sleep, oral intake, perceptions of pre-operative education, and pain expectation). A prospective, r... | 18,757,103 |
Effective rates of heavy metal release from alkaline wastes--quantified by column outflow experiments and inverse simulations. | Column outflow experiments operated at steady state flow conditions do not allow the identification of rate limited release processes. This requires an alternative experimental methodology. In this study, the aim was to apply such a methodology in order to identify and quantify effective release rates of heavy metals f... | 18,757,112 |
Upper limb motor strategies in persons with and without shoulder impingement syndrome across different speeds of movement. | Activities requiring repetitive arm movements, including high velocity actions, have been identified as a risk factor for shoulder impingement. However, the effect of speed on upper limb motor strategies has yet to be evaluated for individuals with shoulder impingement. The aims of this study were to characterize upper... | 18,757,123 |
Distribution of toxic trace elements in soil/sediment in post-Katrina New Orleans and the Louisiana Delta. | This study provided a comprehensive assessment of seven toxic trace elements (As, Pb, V, Cr, Cd, Cu, and Hg) in the soil/sediment of Katrina affected greater New Orleans region 1 month after the recession of flood water. Results indicated significant contamination of As and V and non-significant contamination of Cd, Cr... | 18,757,126 |
Photocatalytic degradation of p-phenylenediamine with TiO2-coated magnetic PMMA microspheres in an aqueous solution. | This study investigates the photocatalytic degradation of p-phenylenediamine (PPD) with titanium dioxide-coated magnetic poly(methyl methacrylate) (TiO2/mPMMA) microspheres. The TiO2/mPMMA microspheres are employed as novel photocatalysts with the advantages of high photocatalytic activity, magnetic separability, and g... | 18,757,136 |
Heart rate features in fetal behavioural states. | Fetal behavioural states have been defined on the basis of eye movements, body movements and heart rate patterns as presented by cardiotocography (CTG). The aim of this work was to determine whether behavioural states can be distinguished on the basis of heart rate features alone using high resolution beat-to-beat feta... | 18,757,143 |
The presence of urinary nitrites is a significant predictor of pediatric urinary tract infection susceptibility to first- and third-generation cephalosporins. | Previous studies in adults have refuted the use of nitrites as a predictor of bacterial resistance to both trimethoprim-sulfamethoxazole and cephalosporins. Some centers now consider first-line outpatient therapy with an oral third-generation cephalosporin appropriate for young children. The objective of this study was... | 18,757,159 |
HPV testing versus repeat Pap testing for the management of a minor abnormal Pap smear: evaluation of a decision aid to support informed choice. | To examine women's informed preference for the management of a mildly abnormal Pap smear and the impact of a decision aid. Women (n=106) were given a choice of management supported by a decision aid and surveyed before, and after decision making to evaluate predictors of choice and decision aid impact. HPV triage was p... | 18,757,164 |
Minimal access breast surgery: a single breast incision for breast conservation surgery and sentinel lymph node biopsy. | Minimal access breast surgery (MABS) is a procedure that completes breast conservation surgery (BCS) and sentinel node biopsy (SNB) through a single incision. It allows access to axillary sentinel nodes via the breast incision and also provides access to the internal mammary nodes (IMN) as well as other nodal sites whe... | 18,757,165 |
In vivo wear rate of the Birmingham Hip Resurfacing arthroplasty. A review of 10 retrieved components. | The wear of 8 femoral and 2 acetabular components of the Birmingham Hip Resurfacing (Midland Medical Technologies Ltd, Birmingham, UK) was measured using a coordinate measuring machine (CMM5; SIP, Geneva, Switzerland). After a median in situ time of 13 months, measurements of the Birmingham Hip Resurfacing femoral head... | 18,757,168 |
Clinical trials for children with cancer in Europe - still a long way from harmonisation: a report from SIOP Europe. | Clinical trials for children with cancer have been particularly hard hit by the introduction of the EU Clinical Trials Directive in 2004. Largely investigator-led and lacking in commercial sponsorship, they have struggled to find the resources necessary to comply with the complex bureaucracy. These rare diseases requir... | 18,757,192 |
Identification of equid herpesvirus-5 in respiratory liquids: a retrospective study of 785 samples taken in 2006-2007. | During a case control study undertaken in 2006-2007, a screening and consensus polymerase chain reaction (PCR) was performed to evaluate the potential role of equid herpesviruses (EHV) in several occurrences of respiratory disorders in 661 horses. Of 785 bronchoalveolar or tracheal lavage fluid samples submitted for an... | 18,757,217 |
Trastuzumab administration associated with change in HER2 status. | Recent results from large randomized clinical trials have demonstrated that administration of trastuzumab reduces the risk of death by half in patients with early-stage breast cancer; however, controversy still exists as to the timing and duration of treatment with trastuzumab in the adjuvant setting and whether its ad... | 18,757,266 |
Global temperature stabilization via controlled albedo enhancement of low-level maritime clouds. | An assessment is made herein of the proposal that controlled global cooling sufficient to balance global warming resulting from increasing atmospheric CO2 concentrations might be achieved by seeding low-level, extensive maritime clouds with seawater particles that act as cloud condensation nuclei, thereby activating ne... | 18,757,272 |
Carbon neutral hydrocarbons. | Reducing greenhouse gas emissions from the transportation sector may be the most difficult aspect of climate change mitigation. We suggest that carbon neutral hydrocarbons (CNHCs) offer an alternative pathway for deep emission cuts that complement the use of decarbonized energy carriers. Such fuels are synthesized from... | 18,757,281 |
Reperfusion-associated hemorrhagic transformation in SHR rats: evidence of symptomatic parenchymal hematoma. | Symptomatic hemorrhagic transformation (HT) is the most important complicating factor after treatment with intravenous tissue plasminogen activator. In this study, we used multimodal magnetic resonance imaging to investigate the incidence and severity of reperfusion-based HT in spontaneously hypertensive rats after isc... | 18,757,286 |
Resident cellular components of the lung: developmental aspects. | In a recent workshop organized by the NIH-NHLBI, investigators working on different aspects of lung biology met to discuss recent progress regarding the origin, development, and characterization of the various cell lineages present in the lung in both normal and disease states. The workshop was entitled "Resident Cellu... | 18,757,315 |
Insulin-like growth factor-I activates gene transcription programs strongly associated with poor breast cancer prognosis. | Substantial evidence implicates insulin-like growth factor-I (IGF-I) signaling in the development and progression of breast cancer. To more clearly elucidate the role of IGF in human breast cancer, we identified and then examined gene expression patterns of IGF-I-treated breast cancer cells. MCF-7 cells were stimulated... | 18,757,322 |
Pharmacodynamic-guided modified continuous reassessment method-based, dose-finding study of rapamycin in adult patients with solid tumors. | Pharmacodynamic studies are frequently incorporated into phase I trials, but it is uncommon that they guide dose selection. We conducted a dose selection study with daily rapamycin (sirolimus) in patients with solid tumors employing a modified continuous reassessment method (mCRM) using real-time pharmacodynamic data a... | 18,757,332 |
LDLs stimulate p38 MAPKs and wound healing through SR-BI independently of Ras and PI3 kinase. | Intracellular signals elicited by LDLs are likely to play a role in the pathogenesis associated with increased LDL blood levels. We have previously determined that LDL stimulation of human skin fibroblasts, used as a model system for adventitial fibroblasts, activates p38 mitogen-activated protein kinases (MAPKs), foll... | 18,757,346 |
Health promotion of faculty and staff: the school nurse's role. | Health promotion of school faculty and staff is an important part of a coordinated school health program. The lack of evaluation of health promotion programs and inconsistent results highlighting the efficacy and benefits of programs adds to employers' perceptions of inconsistent benefits. More studies evaluating effec... | 18,757,350 |
Biomesh placement in laparoscopic repair of paraesophageal hernias. | The placement of mesh in the crural closure of paraesophageal hiatal hernia repairs has been shown to decrease hernia recurrence rates. Typical synthetic mesh are easy to use but have high rate of erosion into the esophagus. Alternatively, biologic mesh decrease the risk of erosion, but are more difficult to manipulate... | 18,757,377 |
Is operative conversion necessary for patients diagnosed with dense adhesions during an elective laparoscopic colectomy? | Laparoscopic colectomy is often complicated by adhesions. Studies examining the morbidity of laparoscopic lysis of adhesions (LOA) combined with colectomy are sparse. The goal of this study was to prospectively evaluate the results of using the harmonic scalpel to lyse adhesions in patients undergoing laparoscopic cole... | 18,757,381 |
Basal cell carcinoma is not granulation tissue in the venous leg ulcer. | The authors present a case of a 76-year-old female with a 7-year history of a nonhealing leg ulcer. The wound surface had epithelial tissue present in a diffuse way with shiny granulations on parts of the edge of the ulcer. A biopsy of the ulcer edge was performed to study the reasons for the absence of response to tre... | 18,757,394 |
Synergistic inhibition with a dual epidermal growth factor receptor/HER-2/neu tyrosine kinase inhibitor and a disintegrin and metalloprotease inhibitor. | The ErbB family of receptors is overexpressed in numerous human tumors. Overexpression correlates with poor prognosis and resistance to therapy. Use of ErbB-specific antibodies to the receptors (Herceptin or Erbitux) or ErbB-specific small-molecule inhibitors of the receptor tyrosine kinase activity (Iressa or Tarceva)... | 18,757,423 |
Chondroitin sulfate E fragments enhance CD44 cleavage and CD44-dependent motility in tumor cells. | During tumor cell invasion, certain extracellular matrix (ECM) components such as hyaluronan (HA) are degraded into small oligosaccharides, which are detected in patients. We previously reported that such HA oligosaccharides induce the proteolytic cleavage of an ECM-binding molecule CD44 from tumor cells and promote tu... | 18,757,435 |
Intraindividual comparative study of corneal and ocular wavefront aberrations after biaxial microincision versus coaxial small-incision cataract surgery. | To compare the optical outcomes of biaxial microincision cataract surgery (B-MICS) versus coaxial small-incision cataract surgery (C-SICS). Thirty patients (sixty eyes) with bilateral age-related cataract underwent B-MICS through a 1.7 mm clear corneal incision (CCI) in one eye and C-SICS through a 2.8-mm CCI in the ot... | 18,757,472 |
Adenosine A2A receptor activation reduces infarct size in the isolated, perfused mouse heart by inhibiting resident cardiac mast cell degranulation. | Mast cells are found in the heart and contribute to reperfusion injury following myocardial ischemia. Since the activation of A2A adenosine receptors (A2AARs) inhibits reperfusion injury, we hypothesized that ATL146e (a selective A2AAR agonist) might protect hearts in part by reducing cardiac mast cell degranulation. H... | 18,757,481 |
Soluble guanylyl cyclase activation by HMR-1766 (ataciguat) in cells exposed to oxidative stress. | Many vascular diseases are characterized by increased levels of ROS that destroy the biological activity of nitric oxide and limit cGMP formation. In the present study, we investigated the cGMP-forming ability of HMR-1766 in cells exposed to oxidative stress. Pretreatment of smooth muscle cells with H(2)O(2) reduced cG... | 18,757,489 |
The paramutated SULFUREA locus of tomato is involved in auxin biosynthesis. | The tomato (Solanum lycopersicum) sulfurea mutation displays trans-inactivation of wild-type alleles in heterozygous plants, a phenomenon referred to as paramutation. Homozygous mutant plants and paramutated leaf tissue of heterozygous plants show a pigment-deficient phenotype. The molecular basis of this phenotype and... | 18,757,490 |
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