title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Proliferation and differentiation of human osteoblasts within 3D printed poly-lactic-co-glycolic acid scaffolds. | Bone repair and regeneration can be enhanced through implantation of biocompatible and biodegradable scaffolds, which serve primarily as osteoconductive moieties. In this study, the mechanical properties and microenviroment of 3D printed poly-lactic-co-glycolic acid (PLGA) scaffolds are examined. Additionally, the prol... | 18,757,495 |
The clinical time-course of experimental autoimmune uveoretinitis using topical endoscopic fundal imaging with histologic and cellular infiltrate correlation. | EAU is an established preclinical model for assessment of immunotherapeutic efficacy toward translation of therapy for posterior uveitis. Reliable screening of clinical features that correlate with underlying retinal changes and damage has not been possible to date. This study was undertaken to describe, validate, and ... | 18,757,507 |
Role of cell and matrix-bound VEGF isoforms in lens development. | To determine the role of vascular endothelial growth factor (VEGF) in embryonic eye development and lens differentiation. Expression of components of the VEGF signaling pathway during lens development and in adults was characterized by beta-galactosidase staining of VEGF-LacZ mice, immunohistochemistry, and real-time (... | 18,757,513 |
Adsorption of human tear lipocalin to human meibomian lipid films. | Tear lipocalin (Tlc) is a major lipid binding protein in tears and is thought to have an important role in stabilizing the Meibomian lipid layer by transferring lipids to it from the aqueous layer or ocular surface, or by adsorbing to it directly. These possible roles have been investigated in vitro using human Tlc. Tl... | 18,757,516 |
Fixation stability, fixation location, and visual acuity after successful macular hole surgery. | This study examined whether changes in fixation stability and fixation location are good predictors of visual acuity after successful macular hole surgery. Ten patients with macular hole were tested before surgery and at 1 and 3 months after surgery. Visual acuity was measured with the ETDRS; fixation stability and fix... | 18,757,517 |
Aromatic amino acid-dependent expression of indole-3-pyruvate decarboxylase is regulated by TyrR in Enterobacter cloacae UW5. | The plant growth-promoting rhizobacterium Enterobacter cloacae UW5 synthesizes the plant growth hormone indole-3-acetic acid (IAA) via the indole-3-pyruvate pathway utilizing the enzyme indole-3-pyruvate decarboxylase that is encoded by ipdC. In this bacterium, ipdC expression and IAA production occur in stationary pha... | 18,757,531 |
The Mycobacterium tuberculosis phoPR operon is positively autoregulated in the virulent strain H37Rv. | The attenuated Mycobacterium tuberculosis H37Ra strain is an isogenic counterpart of the virulent paradigm strain H37Rv. Recently, a link between a point mutation in the PhoP transcriptional regulator and avirulence of H37Ra was established. Remarkably, a previous study demonstrated negative autoregulation of the phoP ... | 18,757,548 |
Molecular remodeling of photosystem II during state transitions in Chlamydomonas reinhardtii. | State transitions, or the redistribution of light-harvesting complex II (LHCII) proteins between photosystem I (PSI) and photosystem II (PSII), balance the light-harvesting capacity of the two photosystems to optimize the efficiency of photosynthesis. Studies on the migration of LHCII proteins have focused primarily on... | 18,757,554 |
The cold-inducible CBF1 factor-dependent signaling pathway modulates the accumulation of the growth-repressing DELLA proteins via its effect on gibberellin metabolism. | Plants have evolved robust mechanisms to respond and adapt to unfavorable environmental conditions, such as low temperature. The C-repeat/drought-responsive element binding factor CBF1/DREB1b gene encodes a transcriptional activator transiently induced by cold that controls the expression of a set of genes responding t... | 18,757,556 |
Specific DNA binding of a potential transcriptional regulator, inosine 5'-monophosphate dehydrogenase-related protein VII, to the promoter region of a methyl coenzyme m reductase I-encoding operon retrieved from Methanothermobacter thermautotrophicus strain DeltaH. | Two methyl coenzyme M reductases (MCRs) encoded by the mcr and mrt operons of the hydrogenotrophic methanogen Methanothermobacter thermautotrophicus DeltaH are expressed in response to H(2) availability. In the present study, cis elements and trans-acting factors responsible for the gene expression of MCRs were investi... | 18,757,575 |
Comparative molecular analysis of endoevaporitic microbial communities. | A phylogenetic comparison of microbial communities in hypersaline evaporites was conducted on crusts from Guerrero Negro, Mexico, and Lindsey Lake, New Mexico, using culture-independent rRNA gene sequence analysis. Many sequences were shared between evaporites, which suggests that similar environments select for specif... | 18,757,573 |
Current status of salivary hormone analysis. | Saliva, which offers a noninvasive and stress-free alternative to plasma and serum, is a widely accepted sample source for analysis of steroids and also of certain amines and peptides. In recent years, numerous publications have described the use of salivary hormone analysis in many fields of clinical and basic researc... | 18,757,583 |
Impact of the seeking safety program on clinical outcomes among homeless female veterans with psychiatric disorders. | Seeking Safety is a manualized cognitive-behavioral therapy intervention that is designed to treat clients with comorbid substance abuse and trauma histories. This study examined its effectiveness when used with homeless women veterans with psychiatric or substance abuse problems at 11 Department of Veterans Affairs me... | 18,757,592 |
Factors related to knowledge retention after crisis intervention team training for police officers. | This study examined whether knowledge scores of Crisis Intervention Team (CIT) officers would decline in the months following CIT training and whether shorter time since training would be a significant predictor of mental health knowledge retention. This study also examined whether sociodemographic and work-related cha... | 18,757,600 |
Reproductive cloning in humans and therapeutic cloning in primates: is the ethical debate catching up with the recent scientific advances? | After years of failure, in November 2007 primate embryonic stem cells were derived by somatic cellular nuclear transfer, also known as therapeutic cloning. The first embryo transfer for human reproductive cloning purposes was also attempted in 2006, albeit with negative results. These two events force us to think caref... | 18,757,615 |
Challenges of informed choice in organised screening. | Despite much research on informed choice and the individuals' autonomy in organised medical screening, little is known about the individuals' decision-making process as expressed in their own words. To explore the decision-making process among women invited to a mammography screening programme. Women living in the coun... | 18,757,624 |
The do-not-resuscitate order: associations with advance directives, physician specialty and documentation of discussion 15 years after the Patient Self-Determination Act. | Since the passage of the Patient Self-Determination Act, numerous policy mandates and institutional measures have been implemented. It is unknown to what extent those measures have affected end-of-life care, particularly with regard to the do-not-resuscitate (DNR) order. Retrospective cohort study to assess association... | 18,757,631 |
What reasons do those with practical experience use in deciding on priorities for healthcare resources? A qualitative study. | Priority setting is necessary in current healthcare services. Discussion of fair process has highlighted the value of developing reasons for allocation decisions on the basis of experience gained from real cases. To identify the reasons that those with experience of real decision-making concerning resource allocation t... | 18,757,635 |
Estimating recurrence of spontaneous preterm delivery. | To identify factors associated with spontaneous preterm birth and to estimate the risk of its recurrence for the second through fourth births among women in Utah who had a first and any subsequent birth between 1989 and 2001, using a retrospective cohort study design. Utah state birth records were reviewed to identify ... | 18,757,647 |
High-concentration supplemental perioperative oxygen to reduce the incidence of postcesarean surgical site infection: a randomized controlled trial. | Most postcesarean infections are caused by anaerobic bacteria. Oxidative killing, an important defense against surgical infections, depends on the oxygen level in contaminated tissue. Among patients undergoing colorectal surgery, perioperative supplemental oxygen decreased infection rates by 50%. We tested the hypothes... | 18,757,651 |
Correlation of catheterized and clean catch urine protein/creatinine ratios in preeclampsia evaluation. | To examine whether clean catch urine specimens correlate with catheterized specimens for determination of protein/creatinine ratios in pregnant women being evaluated for preeclampsia. Sixty pregnant women who were at least at 20 weeks of gestation were enrolled. Patients with ruptured membranes, vaginal bleeding, or ur... | 18,757,659 |
Retinal waves in mice lacking the beta2 subunit of the nicotinic acetylcholine receptor. | The structural and functional properties of the visual system are disrupted in mutant animals lacking the beta2 subunit of the nicotinic acetylcholine receptor. In particular, eye-specific retinogeniculate projections do not develop normally in these mutants. It is widely thought that the developing retinas of beta2(-/... | 18,757,739 |
Toxoplasma gondii Tic20 is essential for apicoplast protein import. | Apicomplexan parasites harbor a secondary plastid that has lost the ability to photosynthesize yet is essential for the parasite to multiply and cause disease. Bioinformatic analyses predict that 5-10% of all proteins encoded in the parasite genome function within this organelle. However, the mechanisms and molecules t... | 18,757,752 |
Structural basis for the catalytic mechanism of human phosphodiesterase 9. | The phosphodiesterases (PDEs) are metal ion-dependent enzymes that regulate cellular signaling by metabolic inactivation of the ubiquitous second messengers cAMP and cGMP. In this role, the PDEs are involved in many biological and metabolic processes and are proven targets of successful drugs for the treatments of a wi... | 18,757,755 |
Mechano-regulated tenascin-C orchestrates muscle repair. | Tenascin-C (TNC) is a mechano-regulated, morphogenic, extracellular matrix protein that is associated with tissue remodeling. The physiological role of TNC remains unclear because transgenic mice engineered for a TNC deficiency, via a defect in TNC secretion, show no major pathologies. We hypothesized that TNC-deficien... | 18,757,758 |
High-dose methotrexate for elderly patients with primary CNS lymphoma. | The introduction of methotrexate (MTX)-based chemotherapy has improved median survival for patients with primary CNS lymphoma (PCNSL). Older age is a negative prognostic marker in patients with PCNSL and may increase the likelihood of MTX toxicity. We studied the response and adverse effects of intravenous high-dose MT... | 18,757,775 |
Gender has a small but statistically significant effect on clearance of CYP3A substrate drugs. | The role of gender on the disposition of drugs metabolized by cytochrome P4503A (CYP3A) remains controversial. Some sources suggest that CYP3A activity in women exceeds that in men, but evidence to support this position is inconsistent at best. We evaluated 38 data sets in which clearance of CYP3A substrate drugs was s... | 18,757,784 |
Effect of single and repeated doses of ketoconazole on the pharmacokinetics of roflumilast and roflumilast N-oxide. | Effects of single and multiple doses of oral ketoconazole on roflumilast and its active metabolite, roflumilast N-oxide, were investigated in healthy subjects. In study 1, subjects (n = 26) received oral roflumilast 500 microg once daily for 11 days and a concomitant 200-mg single dose of ketoconazole on day 11. In stu... | 18,757,786 |
Production of curcuminoids by Escherichia coli carrying an artificial biosynthesis pathway. | Curcuminoids, which are produced specifically by plants of the order Zingiberales, have long been used as food additives because of their aromatic, stimulant and colouring properties and as traditional Asian medicines because of their anti-tumour, antioxidant and hepatoprotective activities. Curcuminoids are therefore ... | 18,757,796 |
Lactobacillus plantarum response to inorganic carbon concentrations: PyrR2-dependent and -independent transcription regulation of genes involved in arginine and nucleotide metabolism. | Lactobacillus plantarum susbp. plantarum is a capnophilic Gram-positive heterotroph with optimal growth in 4 % CO(2)-enriched air. At low inorganic carbon (C(i)) concentrations, the pyr genes encoding the enzymes of the pyrimidine biosynthetic pathway were overexpressed, in agreement with a previous study showing that ... | 18,757,797 |
Transcriptional interplay among the regulators Rrp2, RpoN and RpoS in Borrelia burgdorferi. | The RpoN-RpoS alternative sigma factor pathway is essential for key adaptive responses by Borrelia burgdorferi, particularly those involved in the infection of a mammalian host. A putative response regulator, Rrp2, is ostensibly required for activation of the RpoN-dependent transcription of rpoS. However, questions rem... | 18,757,798 |
Mitochondrial involvement in aspirin-induced apoptosis in yeast. | We have previously reported that aspirin induces apoptosis in manganese superoxide dismutase (MnSOD)-deficient Saccharomyces cerevisiae cells when cultivated on the non-fermentable carbon source ethanol. Here, we investigated the role of mitochondria in aspirin-induced apoptosis. We report that aspirin had an inhibitor... | 18,757,807 |
The impact of childhood ADHD on dropping out of high school in urban adolescents/ young adults. | To examine cognitive and psychosocial factors associated with high school dropout in urban adolescents with and without childhood ADHD. In a longitudinal study, 49 adolescents/young adults with childhood ADHD and 44 controls who either dropped out or graduated from high school are included. Risk factors examined as pot... | 18,757,845 |
A common inferior pulmonary trunk detected by computed tomography affects atrial fibrillation ablation strategy. | Pulmonary veins (PV) display a variety of anomalies with a common trunk of the inferior pulmonary veins being the most infrequent. We report on a 65-year-old man who underwent an ablation procedure for atrial fibrillation (AF) exclusively based on electro-anatomical mapping. After recurrence of AF, a common trunk of th... | 18,757,868 |
SNAP predicts effect of mutations on protein function. | Many non-synonymous single nucleotide polymorphisms (nsSNPs) in humans are suspected to impact protein function. Here, we present a publicly available server implementation of the method SNAP (screening for non-acceptable polymorphisms) that predicts the functional effects of single amino acid substitutions. SNAP ident... | 18,757,876 |
Molecular pathogenesis of megalencephalic leukoencephalopathy with subcortical cysts: mutations in MLC1 cause folding defects. | Megalencephalic leukoencephalopathy with subcortical cysts (MLC) is a rare type of leukodystrophy, most often caused by mutations in the MLC1 gene. MLC1 is an oligomeric plasma membrane (PM) protein of unknown function expressed mainly in glial cells and neurons. Most disease-causing missense mutations dramatically red... | 18,757,878 |
Patient dose in neonatal units. | Lung disease represents one of the most life-threatening conditions in prematurely born children. In the evaluation of the neonatal chest, the primary and most important diagnostic study is therefore the chest radiograph. Since prematurely born children are very sensitive to radiation, those radiographs may lead to a s... | 18,757,900 |
Transmission dynamics of heritable silencing induced by double-stranded RNA in Caenorhabditis elegans. | Heritable silencing effects are gene suppression phenomena that can persist for generations after induction. In the majority of RNAi experiments conducted in Caenorhabditis elegans, the silencing response results in a hypomorphic phenotype where the effects recede after the F1 generation. F2 and subsequent generations ... | 18,757,930 |
Inducing segmental aneuploid mosaicism in the mouse through targeted asymmetric sister chromatid event of recombination. | Loss or gain of whole chromosomes, or parts of chromosomes, is found in various pathological conditions, such as cancer and aneuploidy, and results from the missegregation of chromosomes during cellular division or abnormal mitotic recombination. We introduce a novel strategy for determining the consequences of segment... | 18,757,940 |
A simple performance test for quantifying the severity of cervical myelopathy. | We evaluated 30 patients with cervical myelopathy before and after decompressive surgery and compared them with 42 healthy controls. All were asked to grip and release their fingers as rapidly as possible for 15 seconds. Films recorded with a digital camera were divided into three files of five seconds each. Three doct... | 18,757,962 |
The viability and proliferation of human chondrocytes following cryopreservation. | Human articular cartilage samples were retrieved from the resected material of patients undergoing total knee replacement. Samples underwent automated controlled freezing at various stages of preparation: as intact articular cartilage discs, as minced articular cartilage, and as chondrocytes immediately after enzymatic... | 18,757,968 |
Grey matter abnormalities in trichotillomania: morphometric magnetic resonance imaging study. | Trichotillomania (repetitive hair-pulling) is an Axis I psychiatric disorder whose neurobiological basis is incompletely understood. Whole-brain trichotillomania neuroimaging studies are lacking. To investigate grey and white matter abnormalities over the whole brain in patients with trichotillomania. Eighteen patients... | 18,757,980 |
[Mechanism underlying osteoarthritis induced by mechanical stress on joint cartilage]. | Osteoarthritis (OA) , one of the most common skeletal disorders characterized by cartilage degradation and osteophyte formation in joints, is induced by accumulated mechanical stress ; however, little is known about the underlying molecular mechanism. Several experimental OA models in mice by producing instability in t... | 18,758,033 |
[Osteocytes and mechanical stress]. | A number of fascinating studies suggest that osteocytes play an important role in bone metabolism, especially in its regulation by mechanical stimuli. However, it has been still discussed how the osteocytes were activated by mechanical stimuli. For example, direct mechanical load applied to cells at levels measured to ... | 18,758,034 |
[TRP channels and mechanical stress]. | Transient receptor potential (TRP) channels respond to diverse external stimuli and convert them into intracellular calcium signals. Recent evidence shows that TRPV4, one of the vanilloid subfamily, plays a key role in mechanosensation in bone. Here I summarize the current knowledge on possible functions of TRP channel... | 18,758,036 |
[PTH and mechanical stress]. | Intermittent administration of PTH increases bone mass by enhancing bone formation. Several mechanisms have been demonstrated for this effect of PTH on bone formation such as the enhancement of Wnt signaling as well as the stimulation of differentiation and the inhibition of apoptosis of cells in the osteoblast lineage... | 18,758,039 |
[Supracondylar and condylar fracture of the humerus]. | Fractures of the distal humerus around the elbow joint are most often in supracondylar or condylar lesion. This article described the diagnosis, classification, treatment, progress, side-effect, after-treatment and rehabilitation of fractures of supracondylar, lateral condyle and medial epicondyle of the humerus in chi... | 18,758,040 |
Dipyridamole therapy improves long-term survival after complete revascularization in patients with impaired cardiac function: a propensity analysis. | Although dipyridamole is no longer used as a mainstream medication for coronary artery disease because of the coronary steal phenomenon, recent studies have shown that the elevation of serum adenosine levels caused by dipyridamole improves cardiac function in heart failure patients. In the present study it was investig... | 18,758,087 |
Sustained release of prostaglandin E1 potentiates the impaired therapeutic angiogenesis by basic fibroblast growth factor in diabetic murine hindlimb ischemia. | Basic fibroblast growth factor (bFGF) is a potent mitogen; however, diabetes mellitus might impair its angiogenic property. Prostaglandin E1 (PGE1) is a potent vasodilator and improves endothelial function. Thus, PGE1 could potentiate the angiogenic properties of bFGF in patients with diabetes mellitus. Streptozotocin-... | 18,758,090 |
Coumarins from campylotropis hirtella (FRANCH.) SCHINDL. and their inhibitory activity on prostate specific antigen secreted from LNCaP cells. | Campylotropis hirtella (FRANCH.) SCHINDL. was used as a folk medicine for the treatment of benign prostate hyperplasia (BPH) in China. In this study, two new coumarins, 7,2',4'-trihydroxy-5-methoxy-3-arylcoumarin (1), 6-[(1S,2S)-2-angeloyloxy-1,3-dihydroxy-3-methylbutyl]-7-methoxycoumarin, named angelol M (2), together... | 18,758,115 |
8'-Hydroxyzearalanone and 2'-hydroxyzearalanol: resorcyclic acid lactone derivatives from the marine-derived fungus Penicillium sp. | Two new 14-membered resorcyclic acid lactone derivatives, 8'-hydroxyzearalanone (1) and 2'-hydroxyzearalanol (2), and four known zearalanone derivatives (3-6) were isolated from the marine-derived fungus Penicillium sp. The structures of compounds 1-6 were elucidated by spectroscopic methods. | 18,758,119 |
Protective effects of lactoferrin against intestinal mucosal damage induced by lipopolysaccharide in human intestinal Caco-2 cells. | Indirect evidence suggests that lactoferrin (Lf), a major iron-binding protein in human milk, induces enterocyte growth and proliferation, depending on its concentration and affects the function and permeability of the intestinal mucosa. The bacterial endotoxin (lipopolysaccharide, LPS) is known to cause mucosal hyperp... | 18,758,152 |
First prenatally detected small supernumerary neocentromeric derivative chromosome 13 resulting in a non-mosaic partial tetrasomy 13q. | Neocentromeres are functional centromeres located in non-centromeric euchromatic regions of chromosomes. The formation of neocentromeres results in conferring mitotic stability to chromosome fragments that do not contain centromeric alpha satellite DNA. We present a report of a prenatal diagnosis referred to cytogeneti... | 18,758,175 |
Pattern of pain management practices of Filipino surgeons. | Among all the fields of specialization in medicine, the surgeons probably encounter the highest number of pain patients, aside from 'causing' many painful conditions due to surgical procedures. It was widely presumed that surgeons in general do not pay much attention to pain management of their patients, often passing ... | 18,758,196 |
Postmarketing surveillance study of OxyContin tablets for relieving moderate to severe cancer pain. | To evaluatethe efficacy and safety of OxyContin tablets (controlled-release oxycodone hydrochloride: 5, 10, 20, and 40 mg) in relieving moderate to severe cancer pain. A multicenter, open-label, prospective, self-controlled clinical trial was used. Pain was relieved in 89.1% of patients within 1 h after drug administra... | 18,758,197 |
Urodynamic evaluation of patients with lower urinary tract symptoms and small prostate volume. | The relevance of prostate size in the pathophysiology of lower urinary tract symptoms (LUTS) is controversial. We evaluated the urodynamic findings in patients with LUTS and small prostate volumes. 84 patients aged >or=50 years with LUTS and prostates <40 ml were evaluated. All had an International Prostate Sympt... | 18,758,208 |
A-to-I RNA editing and cancer: from pathology to basic science. | In eukaryotes mRNA transcripts are extensively processed by different post-transcriptional events such as alternative splicing and RNA editing in order to generate many different mRNAs from the same gene, increasing the transcriptome and then the proteome. The most frequent RNA editing mechanism in mammals involves the... | 18,758,244 |
Percutaneous plating of periarticular tibial fractures: a reliable, reproducible technique for controlling plate passage and positioning. | This article describes percutaneous plating of periarticular tibial fractures, in which a suture, tied to the proximal pole of a precontoured plate, is used to guide the plate through a submuscular tunnel. The technique enables the surgeon to manipulate both poles of the plate during its passage and to accurately posit... | 18,758,289 |
Oral vinorelbine and cisplatin as induction chemotherapy and concomitant chemo-radiotherapy in stage III non-small cell lung cancer: final results of an international phase II trial. | Cisplatin in combination with vinorelbine has reported an optimal activity/tolerance ratio when used in combination with radiotherapy in locally advanced unresectable non-small cell lung cancer. The currently available oral formulation of vinorelbine should be easier to use assuming a similar activity profile. An inter... | 18,758,302 |
Tracheal glomus tumor successfully resected with rigid bronchoscopy: a case report. | Glomus tumor of the trachea is a rare disease. A glomus tumor of the trachea in a 70-year-old man is described. The tumor was successfully excised with rigid bronchoscopy. Twenty-four months after treatment there remains no evidence of endobronchial regrowth at bronchoscopy or imaging studies. Histologic features and t... | 18,758,313 |
Occlusive endobronchial stent placement as a novel management approach to massive hemoptysis from lung cancer. | Massive hemoptysis in patients with advanced thoracic malignancies can be difficult to manage. Frequently, the bleeding source is not amenable to either bronchial artery embolization or surgical resection. Isolation of the bleeding source by endobronchial tamponade is an alternative management option. This is commonly ... | 18,758,315 |
Another cause for conductive hearing loss with present acoustic reflexes. | There are numerous potential causes of conductive hearing loss (HL). It is important to obtain a thorough history and perform a complete examination, including audiometric testing and radiographic evaluation when necessary. In this report, we present a patient with an intact tympanic membrane, no history of ear disease... | 18,758,374 |
Cortical sensorimotor control in vocalization: a functional magnetic resonance imaging study. | Verbal communication is a human feature and volitional vocalization is its basis. However, little is known regarding the cortical areas involved in human vocalization. Therefore, functional magnetic resonance imaging at 3 Tesla was performed in 16 healthy adults to evaluate brain activations related to voice production... | 18,758,379 |
Activation of signal transducers and activators of transcription 3 and overexpression of its target gene CyclinD1 in laryngeal carcinomas. | Constitutive activation of signal transducers and activators of transcription (STAT) 3 has been observed in many solid tumors including head and neck squamous cell carcinoma. Expression and activation of STAT3 in laryngeal carcinoma have not been fully understood. The study aims to investigate the expression and activa... | 18,758,380 |
Sleep apnea and mandibular advancement device. Revision of the literature. | Sleep apnea and hypopnea syndrome (SAHS) is a disorder characterized by intermittent and repetitive obstruction of the upper airway provoking pharyngeal collapse. It is characterized clinically by a triad of daytime hypersomnia, snoring and pauses in breathing during sleep that are normally reported by the partner. Pol... | 18,758,397 |
Treatment of condylar fractures: A retrospective cohort study. | Evaluate routine alterations in patients submitted to treatment of unilateral fractures of the mandibular condyle. The sample consisted of 30 patients of both sexes submitted to surgical and nonsurgical treatment. All patients answered an evaluation questionnaire on perception of the Oral Impact on Daily Performances (... | 18,758,405 |
Treatment of bilateral hyperplasia of the coronoid process of the mandible. Presentation of a case and review of the literature. | Bilateral hyperplasia of the coronoid process is infrequent. It consists of an elongation of the coronoid process of the mandible and is, accordingly, a mechanical problem, limiting mouth opening. This article looks at the case of a 28 year-old male with significant limitation on opening his mouth, secondary to bilater... | 18,758,406 |
Behavioral and psychological symptoms in the preclinical stage of Alzheimer's disease. | AD is preceded by a lengthy preclinical period. Neural degeneration may lead to the appearance of behavioral and psychological symptoms, even before other clinical symptoms are manifest. We attempted to evaluate this symptomatology in preclinical AD. We recruited 291 care center residents who did not demonstrate dement... | 18,758,418 |
Growth inhibition of an established A431 xenograft tumor by a full-length anti-EGFR antibody following gene delivery by AAV. | Therapeutic monoclonal antibodies continue to achieve clinical success for the treatment of many different diseases, particularly cancer. However, the production and purification of antibodies continues to be a time and labor-intensive process with considerable technical challenges. Gene-based delivery of antibodies ma... | 18,758,433 |
Novel function of the class I bHLH protein Daughterless in the negative regulation of proneural gene expression in the Drosophila eye. | Two types of basic helix-loop-helix (bHLH) family transcription factor have functions in neurogenesis. Class II bHLH proteins are expressed in tissue-specific patterns, whereas class I proteins are broadly expressed as general cofactors for class II proteins. Here, we show that the Drosophila class I factor Daughterles... | 18,758,436 |
The Creb1 coactivator Crtc1 is required for energy balance and fertility. | The adipocyte-derived hormone leptin maintains energy balance by acting on hypothalamic leptin receptors (Leprs) that act on the signal transducer and activator of transcription 3 (Stat3). Although disruption of Lepr-Stat3 signaling promotes obesity in mice, other features of Lepr function, such as fertility, seem norm... | 18,758,446 |
Dynein is required for polarized dendritic transport and uniform microtubule orientation in axons. | Axons and dendrites differ in both microtubule organization and in the organelles and proteins they contain. Here we show that the microtubule motor dynein has a crucial role in polarized transport and in controlling the orientation of axonal microtubules in Drosophila melanogaster dendritic arborization (da) neurons. ... | 18,758,451 |
Notch signaling regulates tumor angiogenesis by diverse mechanisms. | The Notch signaling pathway is fundamental to proper cardiovascular development and is now recognized as an important player in tumor angiogenesis. Two key Notch ligands have been implicated in tumor angiogenesis, Delta-like 4 and Jagged1. We introduce the proteins and how they work in normal developing vasculature and... | 18,758,482 |
Inhalation of an endothelin receptor A antagonist attenuates pulmonary inflammation in experimental acute lung injury. | We recently demonstrated that inhalation of the endothelin receptor A (ETA) antagonist LU 135252 improved arterial oxygenation and reduced pulmonary artery pressure in experimental acute lung injury (ALI). In this study we analyzed potential immune modulatory effects of inhaled LU 135252 in experimental ALI. ALI was in... | 18,758,498 |
Hybrid digital holographic imaging system for three-dimensional dense particle field measurement. | To apply digital holography to the measurement of three-dimensional dense particle fields in large facilities, we have developed a hybrid digital holographic particle-imaging system. The technique combines the advantages of off-axis (side) scattering in suppressing speckle noise and on-axis (in-line) recording in lower... | 18,758,519 |
Applications of the theory of fluctuation in the regular transmittance through a dispersion of large cylindrical particles to concentration and size measurements. | Four measurement principles based on the theory of fluctuation in the regular transmittance through a dispersion of large cylindrical particles are presented. The principles concern the measurement of particle concentration, particle length classes, particle length, and particle width. In previous publications, the mea... | 18,758,520 |
Two-dimensional integration of a vertical-cavity surface-emitting laser and photodetectors for position sensing. | Noncontact long-range position sensing is desirable for a number of applications. We have designed and fabricated a monolithically integrated vertical-cavity surface-emitting laser (VCSEL) and p-type/intrinsic/n-type (PIN) photodetectors for optical position sensing. Calculations using the reflection from a periodic me... | 18,758,525 |
Time-averaged electronic speckle pattern interferometry in the presence of ambient motion. Part I. Theory and experiments. | An electronic speckle pattern interferometer is introduced that can produce time-averaged interferograms of harmonically vibrating objects in instances where it is impractical to isolate the object from ambient vibrations. By subtracting two images of the oscillating object, rather than the more common technique of sub... | 18,758,536 |
Analysis of surface modes in photonic crystals by a plane-wave transfer-matrix method. | We have developed a plane-wave transfer-matrix method (PWTMM) with the aid of the interpolation technique to analyze the dispersion relation of surface modes in photonic crystal or photonic crystal surface waveguide. The proposed approach has been applied to several surface structures in two-dimensional photonic crysta... | 18,758,543 |
Coherence and polarization of electromagnetic beams modulated by random phase screens and their changes through complex ABCD optical systems. | The change of coherence and polarization of an electromagnetic beam modulated by a random anisotropic phase screen passing through any optical system is found within the framework of complex ABCD-matrix theory This means that the formalism can treat imaging and Fourier transform and free-space optical systems, as well ... | 18,758,562 |
Accurate calculation of reflectance spectra for thick one-dimensional inhomogeneous optical structures and media: stable propagation matrix method. | Numerical instability is usually observed when the propagation matrix method is used to calculate the reflectance and transmittance spectra for the thick one-dimensional inhomogeneous optical structures and media. To remove this numerical instability we applied two procedures, the normalization and the singular-value d... | 18,758,574 |
Fiber-array-based detection scheme for single-shot pulse contrast characterization. | We propose and demonstrate a fiber-array-based detection scheme for single-shot pulse contrast characterization. The parallel to serial mapping using the fiber array allows the use of a high-sensitivity photomultiplier tube and eliminates the external neutral density filter, both resulting in significantly improved dyn... | 18,758,581 |
Fluorescent or not? Size-dependent fluorescence switching for polymer-stabilized gold clusters in the 1.1-1.7 nm size range. | The synthesis of fluorescent water-soluble gold nanoparticles by the reduction of a gold salt in the presence of a designed polymer ligand is described, the size and fluorescence of the particles being controlled by the polymer to gold ratio; the most fluorescent nanomaterial has a 3% quantum yield, a 1.1 nm gold core ... | 18,758,601 |
Direct, facile synthesis of N-acyl-alpha-amino amides from alpha-keto esters and ammonia. | N-acyl-alpha-amino amides were prepared, without the necessity of chromatographic purification, in a single step by heating the corresponding alpha-keto ester in methanolic ammonia. | 18,758,623 |
Structures of two haptotropic isomers generated by the sliding of 1,3,5-triene ligands on a Pd-Pd-Pd chain. | Two haptotropic isomers of [Pd3(micro3-DMVC)2(CH3CN)2][BF4]2 (DMVC=1,2-di-(E)-carbomethoxyvinylcyclopentene) were structurally determined by X-ray crystallographic analyses; a monoclinic crystal contained a symmetric sandwich complex (micro3-eta2:eta2:eta2-coordination of DMVC ligands) and a triclinic crystal contained... | 18,758,626 |
Cellular and molecular mechanisms underlying neurorehabilitation after stroke in aged subjects. | Old age is associated with an enhanced susceptibility to stroke and poor recovery from brain injury, but the cellular processes underlying these phenomena are uncertain. Therefore studying the basic mechanism underlying functional recovery after brain ischemia in aged subjected it is of considerable clinical interest. ... | 18,758,632 |
Histopathological factors as predictors for survival in colon and rectal cancers. | Colorectal cancer is one of the most frequent malignant diseases with a raising incidence in Romania. Survival at 5-years even was improved in the last decade, remains low especially because of delayed diagnosis. Many clinical-biological and pathological factors have demonstrate a good prognostic value over the time bu... | 18,758,642 |
Study of the correlation between newborn and fetus ages and some morphometric cervical vertebral arches indices. | Establishing the newborn and fetus age by taking into account of cervical vertebral bony parts dimensions is useful in anthropology and anthropometry as well. In the present study, we tried to determine some morphometric indices of fifth bony part's cervical vertebral arch in both fetus and newborn. We analyzed their c... | 18,758,645 |
Acid rain phenomenon in niger delta region of Nigeria: economic, biodiversity, and public health concern. | Rain samples were collected from Warri and Port Harcourt, two major oil-producing cities of Nigeria in April-June, July-August, and September-October 2005 and 2006. Awka, a "non-oil" city was used as control. Samples were collected from three points, using clean plastic basins fastened to a table, 2 m above ground leve... | 18,758,657 |
The physiotherapy clinical outcome variables scale predicts length of hospital stay, discharge destination and future home facility in the acute comprehensive stroke unit. | The aims of this study were: to follow the course of recovery of motor function following acute stroke, as assessed by the Physiotherapy Clinical Outcome Variables Scale (COVS), and; to investigate the ability of this instrument to predict length of hospital stay, discharge destination and future home facility. In this... | 18,758,668 |
A randomized controlled trial of acupuncture added to usual treatment for fibromyalgia. | To evaluate the effectiveness of acupuncture for fibromyalgia. Fifty-eight women with fibromyalgia were allocated randomly to receive either acupuncture together with tricyclic antidepressants and exercise (n=34), or tricyclic antidepressants and exercise only (n=24). Patients rated their pain on a visual analogue scal... | 18,758,677 |
Mobility of heavy metals from soil into hot pepper fruits: a field study. | Capsaicin and dihydrocapsaicin contribute to pungency as well as having health-promoting properties, in peppers. Twenty-three genotypes (four spp.) of hot pepper from the USDA germplasm collection were grown in the field to identify accessions having increased concentrations of these two compounds and determine the con... | 18,758,679 |
High number of striatal dopaminergic neurons during early postnatal development: correlation analysis with dopaminergic fibers. | Dopamine (DA) axons in the developing striatum cluster in discrete areas called "DA islands". During the third postnatal week, most DA islands are no-longer detectable and the DA innervation becomes uniform. In this study we explored the relationship between the pattern of DA innervation and the number of striatal tyro... | 18,758,687 |
Analysis of the downstream region of nodD3 P1 promoter by deletion and complementation tests in Sinorhizobium meliloti. | In Sinorhizobium meliloti, the nodD3 gene is transcriptionally controlled by two promoters, P1 and P2. Under P1, there is a 660 bp sequence including a small open reading frame, ORF2, followed by the nodD3 coding region. Genetic analysis using the different deletions on the 3' ends of P1 downstream sequence showed that... | 18,758,707 |
A study of gene transfer and expression of human clotting factor IX in hemophilia B mice mediated by mini-adenoviral vector. | Vector Gti'IX containing human clotting factor IX cDNAwith intron 1 (hFIX mini-gene or Fi'IX) driven by CMV promoter was constructed based on the mini-adenoviral vector GT2073 (mini-Ad vector) with all viral protein coding sequences deleted. Mini-Ad packaging cell 293Cre4 was first transduced with GTi'IX, and then was ... | 18,758,720 |
Map-based cloning of the ALK gene, which controls the gelatinization temperature of rice. | Gelatinization temperature (GT) is an important parameter for evaluating the cooking and eating quality of rice besides amylose content (AC). The inheritance of the genes affecting GT has been widely studied and is considered to be controlled by a major gene. Here, we report the map-based cloning of rice ALK that encod... | 18,758,723 |
Soft tissue tension in extension in total knee arthroplasty affects postoperative knee extension and stability. | The purpose of this study was to assess correlation of soft tissue tension in extension with postoperative extension deficit and valgus/varus instability. Sixty-four osteoarthritic knees that underwent primary total knee arthroplasty were investigated. Soft tissue tension in extension was measured during operation with... | 18,758,749 |
Individual differences in acute alcohol impairment of inhibitory control predict ad libitum alcohol consumption. | Research has begun to examine how acute cognitive impairment from alcohol could contribute to alcohol abuse. Specifically, alcohol-induced impairment of inhibitory control could compromise the drinker's ability to stop the self-administration of alcohol, increasing the risk of binge drinking. The present study was desi... | 18,758,758 |
Drug discrimination and neurochemical studies in alpha7 null mutant mice: tests for the role of nicotinic alpha7 receptors in dopamine release. | The nicotine discriminative stimulus has been linked to beta2-containing (beta2*) nicotinic receptors, with little evidence of a role for alpha7 nicotinic receptors, because nicotine discrimination was very weak in beta2 null mutant mice but normal in alpha7 mutants. As both alpha7 and beta2* nicotinic receptors have b... | 18,758,759 |
High variability in the MHC class II DA beta chain of the brushtail possum (Trichosurus vulpecula). | The diversity of class II major histocompatibility complex (MHC) loci was investigated in the brushtail possum, an important marsupial pest species in New Zealand. Immunocontraception, a form of fertility control that generates an autoimmune response, is being developed as a population control method for the possum. Be... | 18,758,765 |
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