title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Isolated posterior cruciate ligament injuries associated with closed tibial shaft fractures: a report of two cases. | Knee ligament injuries associated with tibia shaft fractures are usually neglected and treatment is delayed. To our knowledge, no case presentation discusses the clinical result of closed tibial shaft fracture with concomitant ipsilateral isolated PCL injury. In this literature, we report the clinical result of two cas... | 18,758,794 |
Expression of matrix metalloproteinases and their inhibitors in cords and nodules of patients with Dupuytren's disease. | Dupuytren's disease is a fibroproliferative disorder characterized by thickening of the palmar fascia. Several studies indicate that MMPs and TIMPs may play a key role in the onset or progression of Dupuytren's disease and related disorders. In this study, we used a quantitative reverse-transcription PCR methodology to... | 18,758,795 |
MRI appearances of acute idiopathic scrotal oedema in an adult. | Acute idiopathic scrotal oedema is an uncommon cause of acute painless scrotal swelling that is usually seen in children. Traditionally, ultrasound has been used to help establish the diagnosis in the appropriate clinical setting. We report the MRI appearances of acute idiopathic scrotal oedema in a 51-year-old male wi... | 18,758,833 |
Bacterial succession within an ephemeral hypereutrophic Mojave Desert playa Lake. | Ephemerally wet playas are conspicuous features of arid landscapes worldwide; however, they have not been well studied as habitats for microorganisms. We tracked the geochemistry and microbial community in Silver Lake playa, California, over one flooding/desiccation cycle following the unusually wet winter of 2004-2005... | 18,758,846 |
HA/GSA-Rmax ratio as a predictor of postoperative liver failure. | Postoperative mortality after hepatectomy remains high compared with other types of surgery in patients who have cirrhosis or chronic hepatitis. Although there are several useful perioperative markers of liver dysfunction, there are no standard markers for predicting postoperative liver failure. This study investigated... | 18,758,848 |
Prognosis of Japanese breast cancer based on hormone receptor and HER2 expression determined by immunohistochemical staining. | We classified Japanese breast cancer patients based on estrogen receptor (ER), progesterone receptor (PR), and HER2 protein expression and compared their prognoses. We compared the background and prognostic factors of 600 patients with breast cancer who were assigned to the following groups: luminal A (ER + and/or PR +... | 18,758,851 |
Comparison between open and laparoscopic repair of perforated peptic ulcer disease. | The place of laparoscopic repair of perforated peptic ulcer followed by peritoneal toilet has been established, although it is not routinely practiced. This prospective study compared laparoscopic and open repair of perforated peptic ulcer disease. We evaluated whether the early results from laparoscopic repair resulte... | 18,758,854 |
Lung function response to 12-week treatment with combined inhalation of long-acting beta2 agonist and glucocorticoid according to ADRB2 polymorphism in patients with chronic obstructive pulmonary disease. | Recent reports suggest that beta(2)-adrenergic receptor (ADRB2) genotypes are associated with therapeutic responses to beta(2) agonists in asthmatics. However, few studies have investigated therapeutic responses to beta(2) agonists in chronic obstructive pulmonary disease (COPD) patients. This study investigated immedi... | 18,758,858 |
NtbZIP60, an endoplasmic reticulum-localized transcription factor, plays a role in the defense response against bacterial pathogens in Nicotiana tabacum. | A spermine-based signal transduction pathway plays a defensive role against incompatible pathogens. We identified a novel spermine-responsive cDNA from Nicotiana tabacum that encodes a basic region/leucine zipper protein with a putative transmembrane domain. Identity to Arabidopsis thaliana AtbZIP60 was sufficiently hi... | 18,758,894 |
Independent and combined effect of nutrition and exercise on bone mass development. | Food intake provides the necessary components for adequate metabolic functions in bone. Calcium, phosphorus, vitamin D, magnesium, proteins, and fluoride are some of the most important nutrients in this regard. These have different effects on bone mass. Additionally, exercise has been shown to elicit osteogenic respons... | 18,758,899 |
Cyclic AMP enhances Smad-mediated BMP signaling through PKA-CREB pathway. | We present experimental results indicating involvement of cyclic AMP (cAMP)-mediated signaling in bone morphogenetic protein (BMP)-induced osteoblastic gene expression at the transcriptional level by luciferase activity assay in C2C12 cells using the promoter sequence of the Id1 gene, an early-response gene to BMPs, wh... | 18,758,906 |
Matrix vesicles are carriers of bone morphogenetic proteins (BMPs), vascular endothelial growth factor (VEGF), and noncollagenous matrix proteins. | Matrix vesicles (MVs) are well positioned in the growth plate to serve as a carrier of morphogenetic information to nearby chondrocytes and osteoblasts. Bone morphogenetic proteins (BMPs) carried in MVs could promote differentiation of these skeletal cells. Vascular endothelial growth factor (VEGF) in MVs could stimula... | 18,758,911 |
Relative efficacies of alpha-tocopherol, N-acetyl-serotonin, and melatonin in reducing non-enzymatic lipid peroxidation of rat testicular microsomes and mitochondria. | In this study, we examined the relative efficacies of alpha-tocopherol, N-acetyl-serotonin, and melatonin in reducing ascorbate-Fe(2+) lipid peroxidation (LPO) of rat testicular microsomes and mitochondria. Special attention was paid to the changes produced on the highly polyunsaturated fatty acids (PUFAs) C20:4 n6 and... | 18,758,914 |
3D polycaprolactone scaffolds with controlled pore structure using a rapid prototyping system. | Designing a three-dimensional (3-D) ideal scaffold has been one of the main goals in biomaterials and tissue engineering, and various mechanical techniques have been applied to fabricate biomedical scaffolds used for soft and hard tissue regeneration. Scaffolds should be biodegradable and biocompatible, provide tempora... | 18,758,915 |
The future of implantable defibrillator and cardiac resynchronization therapy trials. | Implantable cardioverter defibrillator (ICD) trials were initially limited to survivors of sudden death. The focus of defibrillator trials in the last decade has been in prophylactic implantation of the device in high risk populations for the prevention of sudden cardiac death. It is the contention in this review that ... | 18,758,929 |
Evaluation of insulin and ascorbic acid effects on expression of Bcl-2 family proteins and caspase-3 activity in hippocampus of STZ-induced diabetic rats. | Effects of insulin and ascorbic acid on expression of Bcl-2 family proteins and caspase-3 activity in hippocampus of diabetic rats were evaluated in this study. Diabetes was induced in Wistar male rats by streptozotocin (STZ). Six weeks after verification of diabetes, the animals were treated for 2 weeks with insulin o... | 18,758,938 |
Pulque, an alcoholic drink from rural Mexico, contains phytase. Its in vitro effects on corn tortilla. | Pulque is made by fermenting the agave sap or aguamiel of Agave atrovirens with a whole array of microorganisms present in the environment including several lactic acid bacteria and yeasts such as Saccharomyces cerevisiae. Ascorbic acid was determined in pulque and aguamiel, respectively. Phytase activity in lees, liqu... | 18,758,961 |
Antioxidative and antigenotoxic activity of extracts from cosmos (Cosmos bipinnatus) flowers. | The Cosmos bipinnatus has been used in a traditional herbal remedy for various diseases such as jaundice, intermittent fever, and splenomegaly. The present study describes the preliminary evaluation of antioxidant activities and antigenotoxic effect of Cosmos bipinnatus flowers according to four different colors (white... | 18,758,962 |
Diagnosis, staging, and surgical treatment of malignant pleural mesothelioma. | The clinical presentation of malignant pleural mesothelioma (MPM) is nonspecific. The process to obtain the correct diagnosis can be challenging and requires a high index of suspicion. Once the diagnosis is made, there is no universally accepted standard of care and treatment decisions are strongly influenced by physic... | 18,758,965 |
Utilization of an intron located polyadenlyation site resulted in four novel glutamate decarboxylase transcripts. | Glutamate decarboxylase (GAD) is the rate-limiting enzyme in the synthesis of gamma-aminobutyric acid (GABA), the most important inhibitory neurotransmitter in central nervous system (CNS). Two homologous forms of GAD encoded by separate genes have been identified in mammalian brain, with molecular weight of 65 kDa (GA... | 18,758,993 |
Cold adaptation of a mesophilic cellulase, EG III from Trichoderma reesei, by directed evolution. | Cold-active enzymes have received little research attention although they are very useful in industries. Since the structure bases of cold adaptation of enzymes are still unclear, it is also very difficult to obtain cold-adapted enzymes for industrial applications using routine protein engineering methods. In this work... | 18,759,020 |
Rice bZIP protein, REB, interacts with GCN4 motif in promoter of Waxy gene. | A bifactorial endosperm box (EB), which contains an endosperm motif (EM) and a GCN4 motif, was found in rice Wx promoter. EB was found in 5' upstream region of many seed storage protein genes accounting for these genes expression exclusive in endosperm among various cereals. Many reports demonstrated that the bZIP tran... | 18,759,022 |
Genetic mapping of a new semi-dwarf gene, sd-t(t), in indica rice and estimating of the physical distance of the mapping region. | Application and functional study of dwarf and semi-dwarf genes are of great importance to both crop breeding and molecular biology. A new semi-dwarf gene, sd-t(t), non-allelic to sd-1, had been identified in an indica rice variety, Aitaiyin 2. In this study the gene was genetically mapped by using an F(2) population, w... | 18,759,026 |
beta-amylase in developing apple fruits: activities, amounts and subcellular localization. | Starch degradation in cells is closely associated with cereal seed germination, photosynthesis in leaves, carbohydrate storage in tuberous roots, and fleshy fruit development. Based on previously reported in vitro assays, beta-amylase is considered one of the key enzymes catalyzing starch breakdown, but up to date its ... | 18,759,031 |
Negative phototropism of rice root and its influencing factors. | Some characteristics of the rice (Oryza sativa L.) root were found in the experiment of unilaterally irradiating the roots which were planted in water: (i) All the seminal roots, adventitious roots and their branched roots bent away from light, and their curvatures ranged from 25 degrees to 60 degrees . The curvature o... | 18,759,036 |
Putative cytochrome P450 genes in rice genome (Oryza sativa L. ssp. indica) and their EST evidence. | We discovered 528 putative cytochrome P450s (P450s) in Oryza sativa L. ssp. indica using Arabidopsis thaliana P450s as database. Those putative rice P450s are thought to belong to 40 families classified in Arabidopsis thaliana. We compared distributions of Arabidopsis thaliana and Oryza sativa P450s and found the two s... | 18,759,039 |
Up-regulation of micro-RNA-221 (miRNA-221; chr Xp11.3) and caspase-3 accompanies down-regulation of the survivin-1 homolog BIRC1 (NAIP) in glioblastoma multiforme (GBM). | Glioblastoma multiforme (GBM) represents a class of malignant gliomas which rapidly proliferate, invade and destroy surrounding brain tissues. This study examined micro-RNA (miRNA) speciation and miRNA effects on gene expression in six ATCC glioma and GBM cell lines and in 14 glioma and GBM samples obtained from human ... | 18,759,060 |
Current and future therapies of pediatric cardiopulmonary arrest. | To review contemporary guidelines and therapies for pediatric cardiac arrest and discuss potential novel therapies. Key articles and guidelines in the field were reviewed along with recent publications in the fields of neurointensive care and neuroscience germane to cerebral resuscitation. A total of 45 articles were r... | 18,759,090 |
Morphological variability in selected heterocystous cyanobacterial strains as a response to varied temperature, light intensity and medium composition. | The effect of temperature, light and nutrient composition on morphological traits was determined in seven nostocacean cyanobacteria (Anabaena planctonica, A. sphaerica var. conoidea, A. spiroides, Aphanizomenon gracile, Nostoc sp., Scytonema sp., and Tolypothrix sp.). Their morphological variability was high but only s... | 18,759,118 |
Lack of Na(+),K (+)-ATPase expression in intercalated cells may be compensated by Na(+)-ATPase: a study on MDCK - C11 cells. | The lack of Na(+),K(+)-ATPase expression in intercalated cells (IC) is an intriguing condition due to its fundamental role in cellular homeostasis. In order to better understand this question we compared the activities of Na(+),K(+)-ATPase and Na(+)-ATPase in two MDCK cell clones: the C11, with IC characteristics, and ... | 18,759,127 |
Calibration of reference KAP-meters at SSDL and cross calibration of clinical KAP-meters. | In the summer of 2007 the secondary standard dosimetry laboratory (SSDL) in Norway established a calibration service for reference air-kerma product meter (KAP-meter). The air-kerma area product, P(KA), is a dosimetric quantity that can be directly related to the patient dose and used for risk assessment associated wit... | 18,759,141 |
The scourge: moral implications of natural embryo loss. | It is often claimed that from the moment of conception embryos have the same moral status as adult humans. This claim plays a central role in many arguments against abortion, in vitro fertilization, and stem cell research. In what follows, I show that this claim leads directly to an unexpected and unwelcome conclusion:... | 18,759,175 |
A critical analysis of the concept and discourse of 'unborn child'. | Despite its prominence in the abortion debate and in public policy, the discourse of 'unborn patient' has not been subjected to critical scrutiny. We provide a critical analysis in three steps. First, we distinguish between the descriptive and normative meanings of 'unborn child.' There is a long history of the descrip... | 18,759,183 |
[Gastroenterology - accusations and errors in treatment: evaluation of the completed expertise process in internal medicine of the expert committee of North Rhineland for the years 2001 to 2005]. | Since three decades the extrajudical expertise procedures of the Expert Committee and Arbitration Group has served to pacify the doctor-patient relationship. Systematic analyses of accusations and errors provide valuable data that help to avoid treatment errors and liability disputes against physicians. Disease of the ... | 18,759,199 |
[Summary of the annual meeting of the German society for neurogastroenterology and motility, March 28 - 30, 2008 at Castle Hohenkammer]. | The annual meeting of the German Society for Neurogastroenterology and Motility was held at Castle Hohenkammer from 28th to 30th of March 2008 with C. Pehl (Vilsbiburg) as chairman. The members of the Society study the function of the enteric nervous system, gastrointestinal motility, and functional disturbances of the... | 18,759,206 |
[Chances and risks of anti-VEGF therapy]. | Vascular endothelial growth factor (VEGF) plays a pivotal role in angiogenesis. Through regulation of haemodynamics, haematopoesis and the immune system, endocrinology and reparative processes, inhibition of VEGF can cause multiple adverse events. Previous data suggest that--even after intravitreal injection--systemic ... | 18,759,208 |
[Pupillography for the assessment of driver sleepiness]. | Sleepiness behind the wheel is the second most frequent cause of fatal highway accidents when trucks are involved. Spontaneous pupillary oscillations provide objective and quantitative measures of the tonic central nervous activation which is a precondition for higher level mental performance. First experience with thi... | 18,759,210 |
[The present place of video-assisted procedures in thyroid surgery]. | Standardized surgical technique, the use of ultrasonic dissection and neuro- monitoring, have reduced morbidity in thyroid surgery, so that aesthetic aspects and endoscopic or minimally-invasive thyroid surgery have become more important for the patients. We report on minimally-invasive and endoscopic procedures with e... | 18,759,219 |
Two-dimensional fractal growth properties of the filamentous fungus Cryphonectria parasitica: the effects of hypovirus infection. | Whole-colony two-dimensional fractal growth patterns produced by hypovirus-infected Cryphonectria parasitica (EP155/CHV1-EP713) were measured and compared with those produced by the isogenic virus-free strain (EP155) on solid medium. We have quantified statistically significant differences in the rates of expansion and... | 18,759,224 |
Effect of heavy metals on cultural and morphological growth characteristics of halotolerant Penicillium morphotypes. | Four different morphotypes of halotolerant Penicillium isolated from mangroves and salterns, selected on the basis of their morphological dissimilarities, namely, monoverticillate, biverticillate symmetric, biverticillate asymmetric and terverticillate, were studied for their response to the presence of heavy metals - ... | 18,759,233 |
Study of the photochemical properties and conical intersections of [2,2'-bipyridyl]-3-amine-3'-ol. | The two isoelectronic bipyridyl derivatives [2,2'-bipyridyl]-3,3'-diamine and [2,2'-bipyridyl]-3,3'-diol are experimentally known to undergo very different excited-state double-proton-transfer processes, which result in fluorescence quantum yields that differ by four orders of magnitude. In a previous study, these diff... | 18,759,240 |
A hybrid design: case-parent triads supplemented by control-mother dyads. | Hybrid designs arose from an effort to combine the benefits of family-based and population-based study designs. A recently proposed hybrid approach augments case-parent triads with population-based control-parent triads, genotyping everyone except the control offspring. Including parents of controls substantially impro... | 18,759,250 |
Clinical course and prognosis of hand and wrist problems in primary care. | To describe the course of a new episode of hand and wrist problems in general practice and to identify predictors that are associated with poor outcome at short-term and long-term followup. Patients consulting their general practitioner with hand or wrist problems (no prior consultation in the preceding 3 months) were ... | 18,759,252 |
A systematic review of instruments measuring foot function, foot pain, and foot-related disability in patients with rheumatoid arthritis. | To compose an inventory of instruments that have been described to measure foot function (i.e., pressure and/or gait parameters), foot pain, and foot-related disability in rheumatoid arthritis (RA), and to investigate the clinimetric quality of these measures. A systematic search was conducted in Medline, CINAHL, EMBas... | 18,759,256 |
Rho kinase-dependent CCL20 induced by dynamic compression of human chondrocytes. | Mechanical stimulation of cartilage affects tissue homeostasis and chondrocyte function. The chondrocyte phenotype is dependent on cell shape, which is largely determined by the actin cytoskeleton. Reorganization of the actin cytoskeleton results from Rho GTPase activation. The purpose of this study was to examine the ... | 18,759,278 |
Chronic arthritis aggravates vascular lesions in rabbits with atherosclerosis: a novel model of atherosclerosis associated with chronic inflammation. | To determine whether systemic inflammation induced by chronic antigen-induced arthritis (AIA) accelerates vascular lesions in rabbits with atherosclerosis. Two models of atherosclerosis and chronic AIA were combined. Atherosclerosis was induced by coupling a hyperlipemic diet with an endothelial lesion at the femoral a... | 18,759,289 |
The importance of reporting disease activity states in rheumatoid arthritis clinical trials. | To compare the value of reporting treatment effects in rheumatoid arthritis (RA) as relative change from baseline (e.g., American College of Rheumatology [ACR] responder status) with the value of evaluating absolute disease activity states (e.g., remission). We pooled data from several recent RA clinical trials and eva... | 18,759,299 |
Mutation analyses in amyotrophic lateral sclerosis/parkinsonism-dementia complex of the Kii peninsula, Japan. | To clarify the genetic background of amyotrophic lateral sclerosis (ALS)/parkinsonism-dementia complex (PDC) of the Kii peninsula, Japan (Kii ALS/PDC), we performed extended mutation analyses of three patients with pathologically diagnosed Kii ALS/PDC. Direct sequencing analyses were performed in 19 genes, including AL... | 18,759,352 |
Magnetization transfer induced biexponential longitudinal relaxation. | Longitudinal relaxation of brain water (1)H magnetization in mammalian brain in vivo is typically analyzed on a per-voxel basis using a monoexponential model, thereby assigning a single relaxation time constant to all (1)H magnetization within a given voxel. This approach was tested by obtaining inversion recovery (IR)... | 18,759,367 |
Hydrolysis of cellulose by amorphous carbon bearing SO3H, COOH, and OH groups. | The hydrolysis of cellulose into saccharides using a range of solid catalysts is investigated for potential application in the environmentally benign saccharification of cellulose. Crystalline pure cellulose is not hydrolyzed by conventional strong solid Brønsted acid catalysts such as niobic acid, H-mordenite, Nafion ... | 18,759,399 |
Oil-in-oil emulsions: a unique tool for the formation of polymer nanoparticles. | Polymer latex particles are nanofunctional materials with widespread applications including electronics, pharmaceuticals, photonics, cosmetics, and coatings. These materials are typically prepared using waterborne heterogeneous systems such as emulsion, miniemulsion, and suspension polymerization. However, all of these... | 18,759,463 |
Measurement of the field dependent electrophoretic mobility of surface modified silica/AOT suspensions. | We have investigated the electrophoretic mobility of silica spheres in a silica/AOT/paraffin ternary system as a function of the applied electric field and observed a large discrepancy with data published on a similar system ( Jin, F. H. ; Davis, H. T. ; Evans, D. F. Int. Conf. Digital Printing Technol. 1998, 206-209 )... | 18,759,467 |
Photothermal reshaping of gold nanorods depends on the passivating layers of the nanorod surfaces. | Photothermal reshaping of gold nanorods was triggered by pulsed-laser irradiation. The efficiency of the reshaping was strongly dependent on the surface conditions of the gold nanorods. When the gold nanorods were dispersed in concentrated hexadecyltrimethylammonium bromide (CTAB), the gold nanorods were efficiently tr... | 18,759,472 |
Efficient potassium-ion-templated synthesis and controlled destruction of [2]rotaxanes based on cascade complexes. | The triptycene-based macrotricyclic host can form pseudorotaxane-like cascade complexes with anthraquinone and its tetra-azide terminally functionalized derivative in the presence of potassium ions, which subsequently resulted in the synthesis of three novel potassium-ion-templated [2]rotaxanes 10-12 in high yields by ... | 18,759,481 |
Water soluble single-walled carbon nanotubes inhibit stimulated endocytosis in neurons. | We report the use of chemically functionalized water soluble single-walled carbon nanotube (SWNT) graft copolymers to inhibit endocytosis. The graft copolymers were prepared by the functionalization of SWNTs with polyethylene glycol. When added to the culturing medium, these functionalized water soluble SWNTs were able... | 18,759,491 |
Chemical reactivity and biological activity of diketene. | The alkylating potential of diketene (4-methylene-2-oxetanone), the basic unit of many derivatives of pesticides, chemicals, pharmaceuticals, and dyestuffs, was investigated kinetically. The nucleophile 4-( p-nitrobenzyl)pyridine (NBP), a trap for alkylating agents with nucleophilic characteristics similar to DNA bases... | 18,759,502 |
Relationship between p53 expression and gastric cancers in cardia and antrum. | The mutations in p53 gene and accumulation of p53 protein are the most common genetic events in gastric carcinomas. The present study was conducted to compare the frequency of p53 gene overexpression in a consecutive series of adenocarcinomas arising from the cardia and the antrum. This study also evaluates the associa... | 18,759,514 |
Proteomic characterization of primary diffuse large B-cell lymphomas in the central nervous system. | The lack of primary lymphoid tissue within the central nervous system (CNS) confounds our understanding of the pathogenesis of primary CNS lymphomas (PCNSLs). Comparing the protein expression of PCNSLs and sporadic systemic lymphomas (SSLs) provides a useful strategy for identifying a molecular signature that character... | 18,759,588 |
Epilepsy surgery and tuberous sclerosis complex: special considerations. | Epilepsy surgery for medically refractory seizures among patients with tuberous sclerosis complex (TSC) is a well-accepted treatment option. Many epilepsy centers around the world have published their experience over the past several years, supporting the idea that the best seizure control is obtained when a single tub... | 18,759,614 |
Phase I trial: safety and feasibility of intracranial electroencephalography using hybrid subdural electrodes containing macro- and microelectrode arrays. | Cerebral cortex electrophysiology is poorly sampled using standard, low spatial resolution clinical intracranial electrodes. Adding microelectrode arrays to the standard clinical macroelectrode arrays increases the spatial resolution and may ultimately improve the clinical utility of intracranial electroencephalography... | 18,759,625 |
Corpus callosotomy in children with intractable epilepsy using frameless stereotactic neuronavigation: 12-year experience at the Hospital for Sick Children in Toronto. | Although corpus callosotomy has been used effectively since the late 1930s to treat severe, medically intractable seizure disorders, particularly atonic or drop-attack seizures, controversy remains as to when, how, and how much surgery should be performed. Intraoperative determination of the extent of callosotomy, the ... | 18,759,631 |
Recent advances in understanding integrative control of potassium homeostasis. | The potassium homeostatic system is very tightly regulated. Recent studies have shed light on the sensing and molecular mechanisms responsible for this tight control. In addition to classic feedback regulation mediated by a rise in extracellular fluid (ECF) [K(+)], there is evidence for a feedforward mechanism: Dietary... | 18,759,636 |
Characterization of nebulized liposomal amikacin (Arikace) as a function of droplet size. | The stress of nebulization has been shown to alter the properties of liposomal drugs. What has not been demonstrated is whether nebulized liposomes differ as a function of droplet size. Because droplet size influences lung deposition, liposomes with different properties could be deposited in different areas of the lung... | 18,759,656 |
Evaluation of extracellular matrix formation in polycaprolactone and starch-compounded polycaprolactone nanofiber meshes when seeded with bovine articular chondrocytes. | Cartilage defects are a major health problem. Tissue engineering has developed different strategies and several biomaterial morphologies, including natural-based ones, for repairing these defects. We used electrospun polycaprolactone (PCL) and starch-compounded PCL (SPCL) nanofiber meshes to evaluate extracellular matr... | 18,759,665 |
Umbilical cord blood stem cells: induction of differentiation into mesenchymal lineages by cell-cell contacts with various mesenchymal cells. | CD133(+) cells isolated from bone marrow, peripheral blood, or umbilical cord blood (UCB) represent an established source of transplantable hematopoietic progenitors. Further, there is increasing evidence that such CD133(+) cell isolates comprise subpopulations capable of differentiating into several mesenchymal lineag... | 18,759,667 |
Inkjet-mediated gene transfection into living cells combined with targeted delivery. | In this study a novel method of simultaneous gene transfection and cell delivery based on inkjet printing technology is described. Plasmids encoding green fluorescent protein (GFP) were coprinted with living cells (porcine aortic endothelial [PAE] cells) through the ink cartridge nozzles of modified commercial inkjet p... | 18,759,674 |
Reduction in rates of methicillin-resistant Staphylococcus aureus infection after introduction of quarterly linezolid-vancomycin cycling in a surgical intensive care unit. | The burden of infection with antibiotic-resistant gram-positive cocci, including methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE), continues to increase, leading to substantial morbidity and high mortality rates, particularly in intensive care units (ICUs). Creative interve... | 18,759,679 |
Acellular dermal matrix compared with synthetic implant material for repair of ventral hernia in the setting of peri-operative Staphylococcus aureus implant contamination: a rabbit model. | Implant infection is a common clinical complication of abdominal hernia repair. Our objectives were to determine if acellular dermal matrix (ADM) grafts resisted Staphylococcus aureus infection better (as measured by ability to reduce or clear bacterial counts) than synthetic (polytetrafluoroethylene [PTFE]) mesh when ... | 18,759,680 |
Nuclear medicine in the management of thyroid disease. | Thyroid disease management has changed little over the last 60 years and recent work suggests that the older approach remains the most effective. Treatment of benign hyperthyroidism has shown that functional imaging is essentially linked to therapy and uptake of iodine-131 ((131)I) cannot be assumed but should be teste... | 18,759,694 |
Androgen receptor: role and novel therapeutic prospects in prostate cancer. | Androgen receptor (AR) signaling is necessary for the development of prostate cancer. Androgen-deprivation therapy (ADT) for prostate cancer was described over 50 years ago and ADT remains the mainstay of systemic therapy. AR signaling remains intact as the disease evolves to castration-resistant prostate cancer (CRPC)... | 18,759,700 |
Drug-induced serotonin syndrome: a review. | Serotonin syndrome, or serotonin toxicity (ST), is a clinical condition that occurs as a result of an iatrogenic drug-induced increase in intrasynaptic serotonin levels primarily resulting in activation of serotonin(2A) receptors in the central nervous system. The severity of symptoms spans a spectrum of toxicity that ... | 18,759,711 |
Investing in the future: prevention a priority at last. | We won't make progress on preventing disease if we don't try. It's time to try! | 18,759,723 |
Significantly shorter telomeres in T-cells of patients with ZAP-70+/CD38+ chronic lymphocytic leukaemia. | In contrast to other B-cell neoplasias, chronic lymphocytic leukaemia (CLL) is characterized by increased non-leukaemic T-cells. In order to assess their replicative history, telomere length was analyzed in subsets of leucocytes from CLL patients. Naive and memory T-cells from ZAP-70(+)/CD38(+) patients exhibited signi... | 18,759,763 |
Should we protect the strong or the weak? Risk, resilience, and the selection of marine protected areas. | It is thought that recovery of marine habitats from uncontrollable disturbance may be faster in marine reserves than in unprotected habitats. But which marine habitats should be protected, those areas at greatest risk or those at least risk? We first defined this problem mathematically for 2 alternate conservation obje... | 18,759,769 |
Long-term rivastigmine treatment in a routine clinical setting. | The aim of the study was to observe the effects of long-term rivastigmine treatment in patients with mild to moderate Alzheimer's disease (AD) in a routine clinical setting. This was a prospective, open-label, observational, multicentre, non-randomized study. Outcome measures included the Mini Mental State Examination ... | 18,759,798 |
Don't be afraid to treat depression in patients with epilepsy! | Major depression and related depressive disorders are highly prevalent in the general population and even more so in patients with epilepsy. Yet depression in these patients remains underdiagnosed and undertreated. This is particularly worrisome as depression has greater negative impact on quality of life than seizure ... | 18,759,799 |
Clinical evaluation of cessation of hyperopia in 123 children with accommodative esotropia treated with glasses for best corrected vision. | This study aimed to determine age at successful cessation of hyperopic glasses, the influence of hyperopia on the esotropic angle and age at discontinuation of glasses in accommodative esotropia (AE) patients. We performed a retrospective study in 123 AE patients who achieved complete emmetropization and maintained ort... | 18,759,801 |
Neuropsychological profile in bipolar disorder: a preliminary study of monotherapy lithium-treated euthymic bipolar patients evaluated at a 2-year interval. | To investigate the cognitive impairment of a sample of euthymic bipolar patients treated with lithium monotherapy at baseline in a 2-year longitudinal study. Fifteen DSM-IV-TR bipolar out-patients and 15 healthy-matched controls were cognitively assessed twice over a 2-year follow-up. All patients underwent lithium mon... | 18,759,809 |
Investigation of the neural substrates of voice recognition in Chinese schizophrenic patients with auditory verbal hallucinations: an event-related functional MRI study. | Auditory hallucinations (AVHs), like real auditory perceptions, are often perceived as familiar voices. Given that neural correlates of AVHs involve the auditory cortex, it is likely that those brain regions responsible for recognition of voice identity are invoked during AVHs. Schizophrenic patients with (n = 13) and ... | 18,759,811 |
Nested Markov compliance class model in the presence of time-varying noncompliance. | We consider a Markov structure for partially unobserved time-varying compliance classes in the Imbens-Rubin (1997, The Annals of Statistics 25, 305-327) compliance model framework. The context is a longitudinal randomized intervention study where subjects are randomized once at baseline, outcomes and patient adherence ... | 18,759,831 |
Diagnosis of random-effect model misspecification in generalized linear mixed models for binary response. | Generalized linear mixed models (GLMMs) are widely used in the analysis of clustered data. However, the validity of likelihood-based inference in such analyses can be greatly affected by the assumed model for the random effects. We propose a diagnostic method for random-effect model misspecification in GLMMs for cluste... | 18,759,837 |
Ratio estimation with measurement error in the auxiliary variate. | With auxiliary information that is well correlated with the primary variable of interest, ratio estimation of the finite population total may be much more efficient than alternative estimators that do not make use of the auxiliary variate. The well-known properties of ratio estimators are perturbed when the auxiliary v... | 18,759,838 |
Exact confidence bounds following adaptive group sequential tests. | We provide a method for obtaining confidence intervals, point estimates, and p-values for the primary effect size parameter at the end of a two-arm group sequential clinical trial in which adaptive changes have been implemented along the way. The method is based on applying the adaptive hypothesis testing procedure of ... | 18,759,843 |
A latent contingency table approach to dose finding for combinations of two agents. | Two-agent combination trials have recently attracted enormous attention in oncology research. There are several strong motivations for combining different agents in a treatment: to induce the synergistic treatment effect, to increase the dose intensity with nonoverlapping toxicities, and to target different tumor cell ... | 18,759,848 |
Cyclo-oxygenase-1 inhibition increases acid secretion by modulating H+,K+-ATPase expression and activation in rabbit parietal cells. | 1. In the present study, we evaluated the role of cyclo-oxygenase (COX)-1 and COX-2 on gastric acid secretion in rabbit isolated parietal cells and gastric glands by examining [(14)C]-aminopyrine uptake, prostaglandin (PG) E(2) synthesis and COX-1, COX-2 and proton pump expression at baseline and after treatment with v... | 18,759,857 |
The validity and reliability of the occupational contact dermatitis disease severity index. | The occupational contact dermatitis disease severity index (ODDI) was designed to assess the severity and importantly the functional disability caused by occupational contact dermatitis (OCD) of the hands in patients attending our occupational dermatology clinic. To investigate the accuracy of the ODDI. Of 205 patients... | 18,759,896 |
Regulation of hematopoietic cell function by inhibitory immunoglobulin G receptors and their inositol lipid phosphatase effectors. | Numerous autoimmune and inflammatory disorders stem from the dysregulation of hematopoietic cell activation. The activity of inositol lipid and protein tyrosine phosphatases, and the receptors that recruit them, is critical for prevention of these disorders. Balanced signaling by inhibitory and activating receptors is ... | 18,759,919 |
Putting out the fire: coordinated suppression of the innate and adaptive immune systems by SOCS1 and SOCS3 proteins. | The mounting of an effective immune response requires the coordinated function of both the innate and the adaptive arm of the immune system. Cells from both types of immunity respond to antigenic stimuli through a variety of surface and intracellular receptors and produce cytokines that tightly orchestrate the inflamma... | 18,759,933 |
Reduced activation in right lateral prefrontal cortex and anterior cingulate gyrus in medication-naïve adolescents with attention deficit hyperactivity disorder during time discrimination. | Patients with attention deficit hyperactivity disorder (ADHD) under-perform when discriminating between durations differing by several hundred milliseconds. This function involves right prefrontal and anterior cingulate (AC) brain regions, which are structurally and functionally compromised in this patient group during... | 18,759,938 |
Factors associated with knowledge of genetics and nutritional genomics among dietitians. | Knowledge of genetics and nutritional genomics is important for dietitians in the prevention and management of disease. The present study aimed to analyse data from a nationwide postal questionnaire survey in order to investigate the factors associated with knowledge of genetics and nutritional genomics among dietitian... | 18,759,954 |
Pentobarbital versus thiopental in the treatment of refractory intracranial hypertension in patients with traumatic brain injury: a randomized controlled trial. | Experimental research has demonstrated that the level of neuroprotection conferred by the various barbiturates is not equal. Until now no controlled studies have been conducted to compare their effectiveness, even though the Brain Trauma Foundation Guidelines recommend that such studies be undertaken. The objectives of... | 18,759,980 |
"Hook"-calibration of GeneChip-microarrays: chip characteristics and expression measures. | Microarray experiments rely on several critical steps that may introduce biases and uncertainty in downstream analyses. These steps include mRNA sample extraction, amplification and labelling, hybridization, and scanning causing chip-specific systematic variations on the raw intensity level. Also the chosen array-type ... | 18,759,984 |
Effect of sperm parameters on intrauterine insemination pregnancy rate. | To assess the effect of sperm parameters on pregnancy rate following Intrauterine Insemination (IUI) in primary and secondary infertile patients. An observational study. The Assisted Conception Unit, Department of Obstetrics and Gynaecology, Services Institute of Medical Sciences, Lahore, Pakistan, from January 2004 to... | 18,760,044 |
Hypereosinophilic syndrome causing acute hemiplegia in childhood. | Hypereosinophilic syndrome (HES) is a rare heterogeneous group of disorders, characterized by marked peripheral blood and tissue eosinophilia resulting in end organ damage. This case describes a six-year-old girl child who presented with sudden weakness of right half of body and fever. Computed tomogram of brain showed... | 18,760,055 |
Perineal ectopic testis - a rare encounter in paediatric surgical practice. | Perineal ectopic testis is a rare form of testicular maldescent. We report 2 patients with perineal ectopic testes, in one of them, the condition was bilateral (only the 6th case of this variety). Surgery was performed in both cases and testicles were mobilized and fixed in the scrotum. Gubernaculum testis was found to... | 18,760,056 |
Bouveret's syndrome. | Gastric Outlet Obstruction (GOO) due to impaction of a gallstone in the duodenum after migration through a bilioduodenal fistula is known as Bouveret's syndrome. Its clinical symptoms are entirely vague and nonspecific. Because of its rarity, insidiousness and unpredictable symptomatology, Bouveret's syndrome is never ... | 18,760,069 |
Complete Androgen Insensitivity Syndrome. | The incidence of Complete Androgen Insensitivity Syndrome (CAIS) is about 1 in 20,000. People with CAIS are normal appearing females, despite the presence of testes and a 46, XY chromosome constitution. We came across a case in which a 17 years old girl presented with the complaint of inguinal hernia and amenorrhea. Su... | 18,760,072 |
[Infectious complications of surgically treatment pelvic fractures]. | Based on case histories, the authors draw attention to important infectious complications in patients surgically treated for pelvic injuries. These complications were recorded in four out of 75 patients (5.3%) undergoing surgery for pelvic fracture in the period from 2001 to 2005. The chief risk factors for the develop... | 18,760,086 |
Current role of sodium bicarbonate-based preprocedural hydration for the prevention of contrast-induced acute kidney injury: a meta-analysis. | The optimal hydration strategy for prevention of contrast-induced acute kidney injury (AKI) remains unknown. The purpose of this meta-analysis is to compare the effectiveness of normal saline (NS) versus sodium bicarbonate hydration (NaHCO(3)) for prevention of contrast-induced AKI. We performed a meta-analysis of rand... | 18,760,120 |
Treatment of chronic systolic heart failure secondary to Chagas heart disease in the current era of heart failure therapy. | The treatment of chronic heart failure secondary to Chagas disease has been based on extrapolation of data achieved in the treatment of non-Chagas disease heart failure. Because beta-blockers decrease the incidence of sudden cardiac death in non-Chagas disease heart failure and sudden cardiac death occurs preferentiall... | 18,760,121 |
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