title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
|---|---|---|
Electrochemiluminescence detection of dichlorvos pesticide in luminol-CTAB medium. | A simple, novel electrochemiluminescence (ECL) method for the detection of dichlorvos pesticide (DDVP) with high sensitivity was discovered. Detection was carried out in a static ECL system, in which a glassy carbon electrode was selected as the working electrode. ECL parameters, including the concentrations of cetyrlt... | 18,761,159 |
Optimization of serotonin imprinted polymers and recognition study from platelet rich plasma. | Molecularly imprinted polymers using serotonin as the template molecule was prepared for selective recognition from platelet rich plasma by non-covalent imprinting approach. Four different monomers (methacrylic acid, acrylamide, 4-vinylpyridine and 2-acrylamido-2-methylpropane sulfonic acid) and acetonitrile and DMSO a... | 18,761,170 |
A systematic study on extraction of total arsenic from down-scaled sample sizes of plant tissues and implications for arsenic species analysis. | An easily feasible, species-conserving and inexpensive protocol for the extraction of total arsenic and arsenic species from terrestrial plants was designed and applied to the investigation of accumulation and metabolization of arsenite (As(III)), arsenate (As(V)), monomethylarsonate (MMA(V)), and dimethylarsinate (DMA... | 18,761,183 |
Laparoscopic radical cystectomy. | The application of laparoscopic techniques to radical cystectomy has been a recent and natural evolution of successful laparoscopic applications in renal surgery and prostatectomy. The authors' ongoing international registry comprises over 700 cases from 14 countries. Most laparoscopic radical cystectomy (LRC) operatio... | 18,761,199 |
Remifentanil-propofol versus fentanyl-propofol for monitored anesthesia care during hysteroscopy. | To compare the efficacy of remifentanil-propofol with that of fentanyl-propofol for monitored anesthesia care during hysteroscopy. Prospective, randomized study. Operating room and postanesthesia care unit of a university hospital. 30 ASA physical status I and II adult patients undergoing hysteroscopic procedures. Afte... | 18,761,238 |
Frequency of electrocardiographic changes indicating myocardial ischemia during elective cesarean delivery with regional and general anesthesia: detection based on continuous Holter monitoring and serum markers of ischemia. | To determine the frequency of electrocardiographic (ECG) changes and to assess the occurrence of myocardial ischemia during elective cesarean delivery with either regional or general anesthesia. Randomized, prospective, single-blinded clinical trial. Large referral hospital. 40 ASA physical status I and II term parturi... | 18,761,242 |
Intravenous remifentanil and propofol for gastroscopy. | To evaluate the efficiency and safety of intravenous (i.v.) remifentanil and propofol for gastroscopy in healthy adults. Randomized, double-blinded study. Endoscopy Center, West China Hospital, Sichuan University (Chengdu, People's Republic of China). 199 adult ASA physical status I and II patients. Patients were rando... | 18,761,243 |
Relationship of sustained brain natriuretic peptide release after reperfused acute myocardial infarction with gated SPECT infarct measurements and its connection with collagen turnover and left ventricular remodeling. | The relationship among plasma brain natriuretic peptide (BNP), markers of extracellular matrix (ECM) remodeling, and left ventricular (LV) dilation after reperfused acute myocardial infarction is poorly known. Echocardiogram, plasma BNP, and ECM degradation markers (serum amino-terminal telopeptide of type I procollage... | 18,761,267 |
Evaluation of mechanical dyssynchrony and myocardial perfusion using phase analysis of gated SPECT imaging in patients with left ventricular dysfunction. | Using phase analysis of gated single photon emission computed tomography (SPECT) imaging, we examined the relation between myocardial perfusion, degree of electrical dyssynchrony, and degree of SPECT-derived mechanical dyssynchrony in patients with left ventricular (LV) dysfunction. We retrospectively examined 125 pati... | 18,761,269 |
Dolphin natures, human virtues: MacIntyre and ethical naturalism. | Can biological facts explain human morality? Aristotelian 'virtue' ethics has traditionally assumed so. In recent years Alasdair MacIntyre has reintroduced a form of Aristotle's 'metaphysical biology' into his ethics. He argues that the ethological study of dependence and rationality in other species--dolphins in parti... | 18,761,281 |
"Curiously parallel": analogies of language and race in Darwin's Descent of man. A reply to Gregory Radick. | In the second chapter of The descent of man (1871), Charles Darwin interrupted his discussion of the evolutionary origins of language to describe ten ways in which the formation of languages and of biological species were 'curiously' similar. I argue that these comparisons served mainly as analogies in which linguistic... | 18,761,287 |
Caste and maternal health care service use among rural Hindu women in Maitha, Uttar Pradesh, India. | The objective of this study was to examine the association between caste and maternal health care service use among rural Hindu women in India. We analyzed data from the Morbidity and Performance Assessment, a population-based cross-sectional study, for 482 Hindu women who were pregnant during January 1998 to January 1... | 18,761,290 |
Acute death due to hyperextension injury of the cervical spine caused by falling and slipping onto the face. | This retrospective study presents findings of cases involving fatal injuries, in which the victim was found dead at the scene, resulting from cervical hyperextension force attributable to a fall from a low height. External postmortem examination of 14 victims revealed that abrasions and lacerations of the face or the f... | 18,761,315 |
An enhancer required for transcription of the Col6a1 gene in muscle connective tissue is induced by signals released from muscle cells. | Collagen VI is a survival factor for skeletal muscle produced by endomysial cells and localized in connective tissue around muscle fibers. Mutations of its genes (COL6A1, COL6A2 and COL6A3) cause two muscular disorders, Bethlem myopathy and Ullrich disease. Expression of Collagen VI is highly dynamic during development... | 18,761,340 |
Cutaneous leishmaniasis caused by Leishmania infantum transmitted by Phlebotomus tobbi. | Transmission of cutaneous leishmaniasis (CL) caused by Leishmania infantum was studied in South Anatolia, Turkey. Small, non-ulcerating lesions prevailed and patients were negative in rK39 tests for antibody detection for human visceral leishmaniasis (VL). The most abundant sand fly species, Phlebotomus tobbi, was foun... | 18,761,342 |
Attenuation of the cardiovascular and metabolic complications of obesity in CD14 knockout mice. | Although toll-like receptors (TLR) are known to mediate the metabolic complications of obesity, the mechanisms underlying its activation remain largely unknown. The present study analyzed a model of diet-induced obesity in mice lacking the TLR4/TLR2 co-receptor CD14. Six-week-old male mice lacking CD14 (n = 16) were al... | 18,761,356 |
A delay reaction-diffusion model of the dynamics of botulinum in fish. | A model of interaction between fish and a bacterium (Clostridium botulinum) responsible for avian botulism is introduced, considering diffusion of both fish and bacterium in water. The fish population moves randomly in water. Death fish disintegrate in water, at different locations, causing bacteria to diffuse through ... | 18,761,358 |
A Micro-Electrode Array device coupled to a laser-based system for the local stimulation of neurons by optical release of glutamate. | Optical stimulation is a promising approach to investigate the local dynamic responses of cultured neurons. In particular, flash photolysis of caged compounds offers the advantage of allowing the rapid change of concentration of either extracellular or intracellular molecules, such as neurotransmitters or second messen... | 18,761,373 |
Liquid state machines and cultured cortical networks: the separation property. | In vitro neural networks of cortical neurons interfaced to a computer via multichannel microelectrode arrays (MEA) provide a unique paradigm to create a hybrid neural computer. Unfortunately, only rudimentary information about these in vitro network's computational properties or the extent of their abilities are known.... | 18,761,392 |
Molecular cloning and functional characterization of cynomolgus monkey multidrug resistance-associated protein 2 (MRP2). | The monkey is an important experimental model in the pharmacological evaluation of new drugs. We isolated monkey multidrug resistance-associated protein 2 (MRP2) cDNA to examine expression profiles among various tissues and measured ATPase activity to assess substrate specificity. The amino acid sequence encoded by mon... | 18,761,402 |
The salt tolerant yeast Zygosaccharomyces rouxii possesses two plasma-membrane Na+/H+-antiporters (ZrNha1p and ZrSod2-22p) playing different roles in cation homeostasis and cell physiology. | Antiporters exporting Na(+) and K(+) in exchange for protons are conserved among yeast species. The only exception so far has been Zygosaccharomyces rouxii, an osmotolerant species closely related to Saccharomyces cerevisiae. Z. rouxii was described as possessing one plasma-membrane antiporter transporting only Na(+) (... | 18,761,413 |
Monoprotection of diols as a key step for the selective synthesis of unequally disubstituted diamondoids (nanodiamonds). | The monoprotection (desymmetrization) of diamondoid, benzylic, and ethynyl diols has been achieved using fluorinated alcohols such as 2,2,2-trifluoroethanol (TFE) under acidic conditions. This practical acid-catalyzed S(N)1 reaction opens the door for the synthesis of novel bifunctional diamondoids. With diamantane as ... | 18,761,438 |
Fluorescence imaging of intracellular cadmium using a dual-excitation ratiometric chemosensor. | We described here a coumarin-based dual-excitation ratiometric probe for cadmium, CadMQ. This fluorescence sensor has high quantum yields of 0.59 and 0.70 in the metal-free and Cd2+-bound forms, respectively, and has a dissociation constant of 0.16 nM for Cd2+. CadMQ is cell permeable and locates within the acidic comp... | 18,761,452 |
Asymmetric intramolecular arylcyanation of unactivated olefins via C-CN bond activation. | The enantioselective, intramolecular arylcyanation of unactivated olefins via C-CN bond activation has been accomplished using a Ni(0) catalyst and BPh3 co-catalyst. High enantioselectivities are achieved using TangPHOS as a chiral ligand. This method allows the generation of two new C-C bonds and one new quaternary ca... | 18,761,453 |
The technique, validity and clinical use of the sweep VEP. | Vision scientists have concentrated on studying two visual functions when it comes to assessing the sensory visual development in human: visual acuity and contrast sensitivity. The methods used to measure these visual functions can be either behavioral or electrophysiological. A relatively new technique for measuring t... | 18,761,477 |
Assessing the optical performance of multifocal (diffractive) intraocular lenses. | While the optical performance of monofocal refractive lenses can be measured quite easily, more efforts are required to assess the performance of multifocal lenses, due to imaging to several foci. The purpose of this study was to develop a rugged test setup for evaluation of the optical properties of intraocular lenses... | 18,761,484 |
Extranodal gammadelta-T-cell lymphoma in a dog with leishmaniasis. | An 8-year-old intact male mongrel dog with alopecia and weight loss was referred to the Veterinary Faculty of Naples. The dog had pale mucous membranes, enlarged prescapular lymph nodes, and splenomegaly. Laboratory abnormalities included anemia, thrombocytopenia, and hyperglobulinemia. Bone marrow aspirate smears cont... | 18,761,522 |
What is your diagnosis? Biopsy impression smear of a hepatic mass in a yearling Thoroughbred filly. | A 1-year-old Thoroughbred filly was presented to the Cornell University Hospital for Animals with a 10-day history of fever, diarrhea, inappetance, and hypodipsia. Clinical pathology abnormalities found by the referring veterinarian included erythrocytosis, hyperproteinemia, and increased serum gamma-glutamyltransferas... | 18,761,530 |
Long-term safety, tolerability, and efficacy of the novel anti-muscarinic agent imidafenacin in Japanese patients with overactive bladder. | To evaluate the long-term safety, tolerability, and efficacy of imidafenacin, a novel anti-muscarinic agent, in Japanese patients with overactive bladder. Men and women who had overactive bladder symptoms were enrolled for open-label treatment with 0.1 mg of imidafenacin twice daily for 52 weeks; the safety and efficac... | 18,761,536 |
Eggshell pigmentation pattern in relation to breeding performance of blue tits Cyanistes caeruleus. | 1. We test the consequences, in terms of breeding success and parental effort, of eggshell pigmentation pattern in a hole-nesting bird, the blue tit Cyanistes caeruleus that lays eggs asymmetrically speckled with reddish spots (maculated eggs). 2. We assess the effect of distribution of spots (pigment 'spread') and spo... | 18,761,537 |
Abortive aphthous-like oral lesions: an underreported initial presentation of pemphigus vulgaris. | Pemphigus vulgaris (PV) usually presents as non-healing, painful oral erosions, but transient or aphtha-like lesions are not exceptional at the very beginning of the disease leading to the common misdiagnosis of recurrent aphthous stomatitis (RAS). We designed this cross-sectional, questionnaire-based study to evaluate... | 18,761,538 |
Polymorphisms of interleukin-1 and interleukin-2 genes in patients with gastric cancer in Korea. | Interleukin (IL)-1 gene polymorphism has been reported to be associated with the increment of gastric cancer (GC) and the decrement of duodenal ulcers (DU). In addition, IL-2 is known to induce Helicobacter pylori (H. pylori)-associated gastric atrophy, but it is not known whether IL-2 gene polymorphism increases the r... | 18,761,558 |
Development of a re-positionable aortic stent-valve: a preliminary study in swine. | Placement of aortic stent-valves in the proper position is difficult due to the high velocity and oscillation of blood flow and anatomical characteristics. To address this problem, a re-positionable stent-valve was designed and examined in a preliminary animal experiment. Protocols for this animal study were approved b... | 18,761,562 |
The 2008 National Institute of Child Health and Human Development workshop report on electronic fetal monitoring: update on definitions, interpretation, and research guidelines. | In April 2008, the Eunice Kennedy Shriver National Institute of Child Health and Human Development, the American College of Obstetricians and Gynecologists, and the Society for Maternal-Fetal Medicine partnered to sponsor a 2-day workshop to revisit nomenclature, interpretation, and research recommendations for intrapa... | 18,761,565 |
Immediate implant placement: clinical decisions, advantages, and disadvantages. | Implant placement in fresh extraction sockets in conjunction with appropriate guided bone regeneration is well documented. The decision to extract teeth and replace them with immediate implants is determined by many factors, which ultimately affect the total treatment plan. The goal of this article is to review some of... | 18,761,580 |
Psychophysiological assessment of sexual function in women after radiotherapy and total mesorectal excision for rectal cancer: a pilot study on four patients. | The potential contribution of psychological and anatomical changes to sexual dysfunction in female patients following short-term preoperative radiotherapy (5 x 5 Gy) and total mesorectal excision (TME) is not clear. Aim. In this study we assessed female sexual dysfunction in patients who underwent radiotherapy and TME ... | 18,761,589 |
Circadian variation of rectal sensitivity and gastrointestinal peptides in healthy volunteers. | The aim of our study was to identify diurnal variation of perception of rectal distension and the release of gastroenteropancreatic hormones. In 12 healthy male volunteers (25 years, range 22-32), a rectal balloon distension was performed. Rectal perception thresholds (minimal, urge and pain) and rectal compliance were... | 18,761,628 |
Insulin detemir is characterized by a more reproducible pharmacokinetic profile than insulin glargine in children and adolescents with type 1 diabetes: results from a randomized, double-blind, controlled trial. | Insulin detemir (detemir) has previously been shown to be associated with lower within-subject variability compared with other basal insulin preparations in adults with type 1 diabetes mellitus (T1DM). This randomized, double-blind, crossover trial compared the within-subject variability of detemir and insulin glargine... | 18,761,644 |
Assessment of risk factors of poor metabolic control in type 1 diabetic children assisted in a public hospital in Argentina. | To evaluate predictive risk variables of poor diabetes control that are present at the onset of the disease. A prospective cohort study was carried out in a population of children with type 1 diabetes mellitus by means of a survey with information related to the clinical control of the patients, the sociodemographic an... | 18,761,645 |
The role of p53 in pigmentation, tanning and melanoma. | p53 has a central role in skin pigmentation and may impact on melanoma at all stages, however, as it's mutation frequency in melanoma is low, it's role has been somewhat under-appreciated. During normal skin function, p53 in the keratinocyte is a transducer of the skin tanning signal and an essential component of what ... | 18,761,658 |
Linkage and association study of late-onset Alzheimer disease families linked to 9p21.3. | A chromosomal locus for late-onset Alzheimer disease (LOAD) has previously been mapped to 9p21.3. The most significant results were reported in a sample of autopsy-confirmed families. Linkage to this locus has been independently confirmed in AD families from a consanguineous Israeli-Arab community. In the present study... | 18,761,660 |
Diversity and expression of nitrogen fixation genes in bacterial symbionts of marine sponges. | Marine sponges contain complex assemblages of bacterial symbionts, the roles of which remain largely unknown. We identified diverse bacterial nifH genes within sponges and found that nifH genes are expressed in sponges. This is the first demonstration of the expression of any protein-coding bacterial gene within a spon... | 18,761,667 |
Steering patients to safer hospitals? The effect of a tiered hospital network on hospital admissions. | To determine if a tiered hospital benefit and safety incentive shifted the distribution of admissions toward safer hospitals. A large manufacturing company instituted the hospital safety incentive (HSI) for union employees. The HSI gave union patients a financial incentive to choose hospitals that met the Leapfrog Grou... | 18,761,676 |
Contact-dependent growth inhibition requires the essential outer membrane protein BamA (YaeT) as the receptor and the inner membrane transport protein AcrB. | Contact-dependent growth inhibition (CDI) is a phenomenon by which bacterial cell growth is regulated by direct cell-to-cell contact via the CdiA/CdiB two-partner secretion system. Characterization of mutants resistant to CDI allowed us to identify BamA (YaeT) as the outer membrane receptor for CDI and AcrB as a potent... | 18,761,695 |
The major and minor wall teichoic acids prevent the sidewall localization of vegetative DL-endopeptidase LytF in Bacillus subtilis. | Cell separation in Bacillus subtilis depends on specific activities of DL-endopeptidases CwlS, LytF and LytE. Immunofluorescence microscopy (IFM) indicated that the localization of LytF depended on its N-terminal LysM domain. In addition, we revealed that the LysM domain efficiently binds to peptidoglycan (PG) prepared... | 18,761,696 |
Modelling Parkinson-like neurodegeneration via osmotic minipump delivery of MPTP and probenecid. | Mouse models of MPTP intoxication have been used extensively to explore the molecular mechanisms of Parkinson's disease. However, these models present some limitations since; (i) Dopaminergic (DA) cell death occurs rapidly in contrast to the presumably slow evolution of the disease process. (ii) Some of the key histolo... | 18,761,710 |
Constitutive histamine H2 receptor activity regulates serotonin release in the substantia nigra. | The substantia nigra pars reticulata (SNr) forms a principal output from the basal ganglia. It also receives significant histamine (HA) input from the tuberomammillary nucleus whose functions in SNr remain poorly understood. One identified role is the regulation of serotonin (5-HT) neurotransmission via the HA-H(3) rec... | 18,761,715 |
Assessment of the effectiveness of radon screening programs in reducing lung cancer mortality. | The present study was aimed at assessing the health consequences of the presence of radon in Quebec homes and the possible impact of various screening programs on lung cancer mortality. Lung cancer risk due to this radioactive gas was estimated according to the cancer risk model developed by the Sixth Committee on Biol... | 18,761,730 |
Carcinoid tumour of the appendix in children: a case report. | Carcinoids are the most common tumours of the appendix. These tumours show prevalence in white children. The clinical presentation of the appendiceal carcinoids is similar to that of acute appendicitis, although in many cases the tumour is diagnosed incidentally during an operation. The diagnosis should be confirmed h... | 18,761,734 |
Methodology capture: discriminating between the "best" and the rest of community practice. | The methodologies we use both enable and help define our research. However, as experimental complexity has increased the choice of appropriate methodologies has become an increasingly difficult task. This makes it difficult to keep track of available bioinformatics software, let alone the most suitable protocols in a s... | 18,761,740 |
Prevention of radiochemotherapy-induced toxicity with amifostine in patients with malignant orbital tumors involving the lacrimal gland: a pilot study. | To use amifostine concurrently with radiochemotherapy (CT-RT) or radiotherapy (RT) alone in order to prevent dry eye syndrome in patients with malignancies located in the fronto-orbital region. Five patients (2 males, 3 females) with diagnosed malignancies (Non-Hodgkin B-cell Lymphoma, neuroendocrine carcinoma) involvi... | 18,761,746 |
Primary carcinoid tumour of nasal septum. | We present the first reported case of primary carcinoid tumour of the nasal septum. Case report of our experience of a carcinoid tumour of the nasal septum. We discuss our clinical, radiological and pathological findings. An 83-year-old woman presented with a history of left-sided nasal blockage. Clinical examination s... | 18,761,767 |
Porcine circoviruses: a minuscule yet mammoth paradox. | Porcine circovirus type 2 (PCV2) is the primary causative agent for porcine circovirus-associated disease (PCVAD). PCVAD has been the cause of considerable economic losses to the pork industry worldwide. The disease is primarily characterized by wasting, enlarged lymph nodes, jaundice and weight loss in affected weanli... | 18,761,774 |
[Effects of occupation on health of traffic policemen in a city]. | To investigate the health and work status of traffic policemen in a city, and analyze the effect of the occupation on health of them. The prevalent investigation was used to investigate the health status of on-the-job traffic policemen and the effect of the occupation on the health of traffic policemen was studied. Amo... | 18,761,799 |
[Application of the medicine profile in an ambulatory setting]. | A person with a digital signature can access his or her own personal electronic medicinal profile (PEM) which can also be accessed by the person's prescribing doctors. The PEM provides an overview and contains an overview of the prescription medicine sold to the patient over the previous two years. Randomly-selected ge... | 18,761,822 |
[Transient elastography for diagnosing liver fibrosis]. | Liver fibrosis is a known complication to chronic liver diseases. The reference method for diagnosing and assessing the progression of fibrosis or cirrhosis is histological examination of liver tissue. Since there is a slight but significant risk from every invasive procedure, a non-invasive method has been sought. Tra... | 18,761,829 |
[Breakfast habits and overweight in Danish schoolchildren. The role of socioeconomic positions]. | The prevalence of adolescent overweight has increased dramatically, and in many industrialised countries overweight is most prevalent in lower socioeconomic positions (SEP). It is therefore important to examine determinants of overweight and to understand the mechanisms behind social patterning. Several studies show th... | 18,761,839 |
[Analysis of deaths during hospitalization and after discharge from hospital]. | Analysis of deaths during and up to one month after discharge from hospital. For 2006, all deaths during and up to one month after discharge were identified for patients admitted to hospital in Roskilde or Køge. Age, acute or planned hospitalisation, duration of in-hospital stay, department of discharge and main diagno... | 18,761,842 |
[Whole-body magnetic resonance angiography]. | Whole-body magnetic resonance angiography (WB-MRA) is a new approach for diagnosing atherosclerosis. Through utilisation of fast whole-body MRI systems, the arterial system, excluding the intracranial and coronary arteries, can be investigated in one examination. WB-MRA has the potential of replacing conventional cathe... | 18,761,843 |
[Rabies in a cat in Greenland]. | We describe the first case of rabies diagnosed in a cat in Greenland. The cat showed aggressive behaviour one month after the visit of a rabid fox on the premises. Rabies is enzootic in Greenland, the arctic fox being the natural host of rabies virus. Cats are imported in increasing numbers to Greenland and the reporte... | 18,761,847 |
[Clinical aspects of Tourette syndrome]. | Tourette syndrome (TS) is a hereditary, chronic, neurobiological disease, characterized by the presence of motor and vocal tics. The disease is often accompanied by other symptoms: Attention Deficit Hyperactive Disorder (ADHD), Obsessive Compulsive Disorder (OCD), sleeping disorders, learning disabilities, speech disfl... | 18,761,861 |
[Complicated course after conservative treatment of incarcerated inguinal hernia]. | We report a case of intestinal perforation due to manual reduction of incarcerated inguinal hernia. Explorative laparotomy was delayed and first attempted after 21 hours. The patient died as a result of peritonitis. If conservative treatment of incarcerated inguinal hernia is considered, this should be done with cautio... | 18,761,865 |
[Intestinal duplication--an important differential diagnosis to intussusception]. | This is a case report on a 6-month-old child with an intestinal duplication cyst (ID), initially diagnosed as intussusception. As the patient failed to improve clinically after an apparently successful enema reduction, surgery was performed and an ID was found causing compression and strangulation of the ileum. ID shou... | 18,761,866 |
[Surgical correction of pectus carinatum]. | Pectus carinatum (PC) is a protrusion of the sternum due to overgrowth of the costal cartilages. It can have considerable psychological and somatic impact on the patient. Many physicians are unaware of the beneficial effects and low comorbidity related to surgical correction and therefore erroneously advise patients ag... | 18,761,868 |
[Primary childhood vasculitis--new classification criteria]. | Primary vasculitis is seen in both adults and children, but some of the diseases like Kawasaki disease occur primarily in children. The Chapel Hill Classification Criteria for primary vasculitis refers to the size of vessels but has not been validated in children. Recently, new criteria for the classification of childh... | 18,761,873 |
Salmonella infections associated with reptiles: the current situation in Europe. | Salmonella infections are caused by consumption of contaminated food, person-to-person transmission, waterborne transmission and numerous environmental and animal exposures. Specifically, reptiles and other cold blooded animals (often referred to as "exotic pets") can act as reservoirs of Salmonella, and cases of infec... | 18,761,944 |
p53 strikes mTORC1 by employing sestrins. | The guardian of the genome (p53) elicits cell-cycle checkpoints in response to genotoxic stress. p53 also induces a metabolic checkpoint by inhibiting the mammalian target of rapamycin complex 1 (mTORC1). Recent results by Budanov and Karin, (2008) reveal that p53 exerts its effect on mTORC1 through sestrin1 and sestri... | 18,762,019 |
TRPV4-mediated calcium influx regulates terminal differentiation of osteoclasts. | Calcium signaling controls multiple cellular functions and is regulated by the release from internal stores and entry from extracellular fluid. In bone, osteoclast differentiation is induced by RANKL (receptor activator of NF-kappaB ligand)-evoked intracellular Ca(2+) oscillations, which trigger nuclear factor-activate... | 18,762,026 |
Microtensile bond strengths and scanning electron microscopic evaluation of self-adhesive and self-etch resin cements to intact and etched enamel. | The longevity of indirect adhesively cemented restorations is directly related to the bond quality of resin cements to dental tissues. Bonding to cervical enamel can generate significantly lower bond strengths than bonding to other enamel areas. The effect of enamel pretreatment on bond strengths of self-etch and self-... | 18,762,032 |
Reprint of "Cortical reorganization of language functioning following perinatal left MCA stroke" [Brain and Language 105 (2008) 99-111]. | Functional MRI was used to determine differences in patterns of cortical activation between children who suffered perinatal left middle cerebral artery (MCA) stroke and healthy children performing a silent verb generation task. Ten children with prior perinatal left MCA stroke (age 6-16 years) and ten healthy age match... | 18,762,059 |
Transstyloid, translunate fracture-dislocation of the wrist: case report. | Earlier reports have described characteristic fracture-dislocation patterns of the carpus and distal radius. Most result from a fall onto an outstretched arm, with an applied force directed in a radial-to-ulnar direction across the wrist. We present the clinical, radiographic, and arthroscopic findings noted with an un... | 18,762,109 |
Precontoured fixed-angle volar distal radius plates: a comparison of anatomic fit. | To compare distal radius volar fixed-angle plates for anatomic fit. Twenty embalmed radii were stripped of soft tissues. The volar lip (watershed line) on the volar distal radius served as a reference line. Seven volar fixed-angle plates were tested (Acumed Acu-loc Standard, Hand Innovations DVRAW and DVRAN, Synthes Ju... | 18,762,111 |
Metalloproteinase gene expression correlates with clinical outcome in Dupuytren's disease. | We have previously demonstrated that gene expression levels of matrix metalloproteinases (MMPs), related metalloproteinases "a disintegrin and metalloproteinase with thrombospontin motifs" (ADAMTSs), and tissue inhibitors of metalloproteinases (TIMPs) differed when comparing palmar fascia from 19 patients with Dupuytre... | 18,762,113 |
Imaging motor imagery: methodological issues related to expertise. | Mental imagery (MI) is the mental rehearsal of movements without overt execution. Brain imaging techniques have made it possible to identify the brain regions that are activated during MI and, for voluntary motor tasks involving hand and finger movements, to make direct comparison with those areas activated during actu... | 18,762,138 |
A roadmap for drug discovery and its translation to small molecule agents in clinical development for tuberculosis treatment. | Drug discovery and development, from an initial disease treatment concept to a new drug application (NDA), is a complex, lengthy and expensive process. In this review we discuss the key stages of drug discovery and early development, including target identification and validation, assay development and screening, confi... | 18,762,151 |
Subunit mass fingerprinting of mitochondrial complex I. | We have employed laser induced liquid bead ion desorption (LILBID) mass spectrometry to determine the total mass and to study the subunit composition of respiratory chain complex I from Yarrowia lipolytica. Using 5-10 pmol of purified complex I, we could assign all 40 known subunits of this membrane bound multiprotein ... | 18,762,163 |
Effects of novel antituberculosis agents on OmpF channel activity. | Nanopore forming proteins spanning the outer membrane mediate in the diffusion of hydrophilic chemicals through the hydrophobic bacterial cell wall. In this study, the effects of two novel anti-TB derivatives, ethyl alpha-[5-(5-nitro-2-thienyl)-1,3,4-thiadiazole-2-ylthio] acetates and propyl alpha-[5-(5-nitro-2-thienyl... | 18,762,173 |
Cathepsin D: a cellular roadmap. | Cathepsin D is a normal and major component of lysosomes, it is found in almost all cells and tissues of mammals. Present review describes different events in cellular life of cathepsin D mainly its biosynthesis, co-translational and posttranslational modifications, targeting to lysosomes and proteolytic processing and... | 18,762,174 |
Regulation of antiapoptotic MCL-1 function by gossypol: mechanistic insights from in vitro reconstituted systems. | Small-molecule drugs that induce apoptosis in tumor cells by activation of the BCL-2-regulated mitochondrial outer membrane permeabilization (MOMP) pathway hold promise for rational anticancer therapies. Accumulating evidence indicates that the natural product gossypol and its derivatives can kill tumor cells by target... | 18,762,177 |
Activation of protein kinase C enhances NMDA-induced currents in primary cultured cerebellar granule cells: Effect of temperature and NMDA NR2 subunit composition. | The purpose of this study was to determine the effect of protein kinase C (PKC) activation by 100 nM phorbol 12-myristate 13-acetate (PMA) on N-methyl-d-aspartate (NMDA) receptor function with the whole-cell patch-clamp technique. Receptors expressed in primary cultured cerebellar granule cells at days in vitro that re... | 18,762,183 |
Tanshinone IIA reduces macrophage death induced by hydrogen peroxide by upregulating glutathione peroxidase. | Tanshinone IIA is an important ingredient in the herb danshen (Salvia miltiorrhiza), which has been used to treat cardiovascular diseases such as atherosclerosis and angina for hundreds of years in China. There are numerous reports that TIIA has anti-oxidant properties but the chemical structure indicates that TIIA is ... | 18,762,198 |
Distribution and neurochemical characterization of neurons within the nucleus of the solitary tract responsive to serotonin agonist-induced hypophagia. | Pharmacological compounds enhancing serotonergic tone significantly decrease food intake and are among the most clinically efficacious treatments for obesity. However, the central mechanisms through which serotonergic compounds modulate feeding behavior have not been fully defined. The primary relay center receiving vi... | 18,762,217 |
Oral creatine supplementation attenuates L-DOPA-induced dyskinesia in 6-hydroxydopamine-lesioned rats. | L-DOPA-induced dyskinesia (LID) is among the motor complications that arise in Parkinson patients after a prolonged treatment with levodopa (L-DOPA). Since previous transcriptome and proteomic studies performed in the rat model of LID suggested important changes in striatal energy-related components, we hypothesize tha... | 18,762,218 |
The polymeric stability of the Escherichia coli F4 (K88) fimbriae enhances its mucosal immunogenicity following oral immunization. | Only a few vaccines are commercially available against intestinal infections since the induction of a protective intestinal immune response is difficult to achieve. For instance, oral administration of most proteins results in oral tolerance instead of an antigen-specific immune response. We have shown before that as a... | 18,762,221 |
Cell-mediated immunity induced by chimeric tetravalent dengue vaccine in naive or flavivirus-primed subjects. | Three independent, phase 1 clinical trials were conducted in Australia and in USA to assess the safety and immunogenicity of sanofi pasteur dengue vaccine candidates. In this context, Dengue 1-4 and Yellow Fever 17D-204 (YF 17D)-specific CD4 and CD8 cellular responses induced by tetravalent chimeric dengue vaccines (CY... | 18,762,226 |
The effects of childhood disruptive disorder comorbidity on P3 event-related brain potentials in preadolescents with ADHD. | The present study examined the degree to which the P300 component of the visual brain event-related potential and associated task performance deficits often observed in children with attention-deficit hyperactivity disorder (ADHD) are attributable to comorbid childhood disruptive disorders using a community sample of 1... | 18,762,228 |
The F-domain of estrogen receptor-alpha inhibits ligand induced receptor dimerization. | The role of the carboxyl terminal F-domain of estrogen receptor (ERalpha) is uncertain, but evidence suggests that this region may impart internal restraint on ER dimerization in the presence of 17beta-estradiol (E2). To identify the C-terminal residues affecting human ERalpha activation, we created a series of deletio... | 18,762,230 |
Interaction of mitoxantrone with human serum albumin: spectroscopic and molecular modeling studies. | Mitoxantrone (MTX) is a clinically used antitumor anthracycline, which is made available to the target tissues by transport protein human serum albumin (HSA). Being less toxic unlike other member of this family, its binding characteristics are therefore of immense interest. The circular dichroism (CD), fluorescence and... | 18,762,252 |
In vitro human plasma distribution of nanoparticulate paclitaxel is dependent on the physicochemical properties of poly(ethylene glycol)-block-poly(caprolactone) nanoparticles. | In this study, we synthesized and characterized two methoxy poly(ethylene glycol)-block-poly(caprolactone) (MePEG-b-PCL) amphiphilic diblock copolymers, both based on MePEG with a molecular weight of 5000 g/mol (114 repeat units) and PCL block lengths of either 19 or 104 repeat units. Nanoparticles were formed from the... | 18,762,253 |
Can type-1 responses against intracellular pathogens be T helper 2 cytokine dependent? | While control of intracellular pathogens, such as the protozoan Leishmania, is dependent on the generation of type-1 immune responses, the role of T helper 2 cytokines in the disease process is more controversial. Traditionally these cytokines were perceived as counter-regulating type-1 responses and promoting disease ... | 18,762,265 |
Cellular uptake of lipoproteins and persistent organic compounds--an update and new data. | There are a number of interactions related to the transport of lipophilic xenobiotic compounds in the blood stream of mammals. This paper will focus on the interactions between lipoproteins and persistent organic pollutants (POPs) and how these particles are taken up by cells. A number of POPs including the pesticide p... | 18,762,293 |
Methods for the determination of phenolic brominated flame retardants, and by-products, formulation intermediates and decomposition products of brominated flame retardants in water. | Brominated flame retardants (BFRs) are the chemicals of high importance within the REAch framework. In addition to polybrominated diphenyl ethers (PBDEs), hexabromocyclododecane (HBCD) and tetrabromobisphenol A (TBBPA), other BFRs such as bromophenols, intermediates in FR formulation like bromoanilines, and their bromi... | 18,762,297 |
[Cerebrovascular diseases and... skin abnormalities that disclose the diagnosis]. | In many cases, the diagnostic work-up after a stroke can be greatly enhanced by a thorough examination of the skin, since vasculitis or vasculopathies, even if inherited, may affect cerebral vessels and the skin. Skin abnormalities differ depending on familial history, age of the patient, stroke subtype (cerebral infar... | 18,762,305 |
Laser ultrasonic diagnostics of residual stress. | Ultrasonic NDE is one of the most promising methods for non-destructive diagnostics of residual stresses. However the relative change of sound velocity, which is directly proportional to applied stress, is extremely small. An initial stress of 100 MPa produces the result of deltaV/V approximately 10(-4). Therefore meas... | 18,762,308 |
Partitioning and granulometric distribution of metal leachate from urban traffic dry deposition particulate matter subject to acidic rainfall and runoff retention. | Vehicular transportation coupled with urban hydrology is a significant source as well as vector of particulate matter (PM) and particulate-bound metal inventories in urban systems. This study examines the granulometric distribution of metals from dry deposition PM generated from 17 dryfall periods and equilibrium metal... | 18,762,311 |
Short- and long-term effects of immunization against gonadotropin-releasing hormone, using Improvac, on sexual maturity, reproductive organs and sperm morphology in male pigs. | The objective of this study was to determine the short and long term effects of a gonadotropin-releasing hormone (GnRH) vaccine (Improvac Pfizer Ltd.), on sexual maturity, development of the reproductive organs, and the morphology of caudal epididymal spermatozoa in non-castrated male pigs. The pigs were slaughtered 4,... | 18,762,333 |
Evaluation of polymerization shrinkage and hydroscopic expansion of fiber-reinforced biocomposites using optical fiber Bragg grating sensors. | Polymerization shrinkage of dental composite materials is recognized as one of the main reasons for the development of marginal leakage between a tooth and filling material. In addition, hydroscopic expansion due to water sorption is known to cause instability in dental materials. Several methods have been proposed to ... | 18,762,334 |
Age-related changes in multi-finger interactions in adults during maximum voluntary finger force production tasks. | This study aimed to continue our characterization of finger strength and multi-finger interactions across the lifespan to include those in their 60s and older. Building on our previous study of children, we examined young and elderly adults during isometric finger flexion and extension tasks. Sixteen young and 16 elder... | 18,762,348 |
Manufacturing process of reproduction plate by nonmetallic materials reclaimed from pulverized printed circuit boards. | The aim of this study was to present a new method for resource utilization of nonmetallic materials reclaimed from pulverized waste printed circuit boards. A reproduction nonmetallic plate (RNMP) was prepared by adding resin paste, glass fiber and additives into nonmetallic materials using self-made hot-press former. P... | 18,762,372 |
Quinolone-resistance in Salmonella is associated with decreased mRNA expression of virulence genes invA and avrA, growth and intracellular invasion and survival. | A variety of environmental factors, such as oxygen, pH, osmolarity and antimicrobial agents, modulate the expression of Salmonella pathogenicity islands (SPI) genes. This study investigated SPI-1 gene expression and the pathogenicity of quinolone-resistant Salmonella. mRNA expression levels of the invA and avrA genes, ... | 18,762,392 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.