title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
|---|---|---|
Influence of medium components and fermentation conditions on the production of bacteriocin(s) by Bacillus licheniformis AnBa9. | Recently, antibacterial peptides are gaining more attention as an alternative therapeutics and food and other products from spoilage and deterioration. Antibacterial peptide producing strains were isolated from sediments of slaughterhouse sewage wastes. One among them, identified as Bacillus licheniformis inhibited the... | 18,762,415 |
Use of dewatered alum sludge as main substrate in treatment reed bed receiving agricultural wastewater: long-term trial. | This study aims to explore a novel application of dewatered alum sludge cakes (DASC) as the main medium in a single model reed bed to treat phosphorus-rich animal farm wastewater under "tidal flow" operation on a long-term basis. It is expected that the cakes act as the carrier for developing biofilm and also serve as ... | 18,762,417 |
Design, synthesis, and antibacterial activities of novel 3,6-bicyclolide oximes: length optimization and zero carbon linker oximes. | We designed and synthesized a series of novel 3,6-bicyclolide oximes, possessing linkers of varying lengths to the secondary binding site. The E isomers exhibited excellent antibacterial profiles against a broad spectrum of resistant pathogens. | 18,762,418 |
Patterns of diversification in the discus fishes (Symphysodon spp. Cichlidae) of the Amazon basin. | We carried out a phylogeograhic and population genetic analysis of fishes of the taxonomically contentious genus Symphysodon from the Amazon basin in order to test hypotheses of relationships among taxonomic units, and potential processes driving diversification within this genus. We sampled 334 individuals of the genu... | 18,762,435 |
Inconsistent use of terminology in whole body vibration exercise research. | Whole body vibration exercise (WBV) intensity can be manipulated by altering the frequency of oscillations and/or its magnitude. The inconsistencies and inaccuracies reported within the literature that at times challenge the replication and advancement of whole body vibration exercise research are discussed. Although f... | 18,762,453 |
Effect of a traditional Chinese medicine preparation Xindi soft capsule on rat model of acute blood stasis: a urinary metabonomics study based on liquid chromatography-mass spectrometry. | Xindi soft capsule is a traditional Chinese medicine preparation which consists of sea buckthorn flavonoids and sea buckthorn berry oil. In this study, a urinary metabonomics method based on the ultra-performance liquid chromatography combined with quadrupole time-of-flight tandem mass spectrometry (UPLC Q-TOF MS) was ... | 18,762,461 |
Muscarinic-3 acetylcholine receptor autoantibody in patients with systemic sclerosis: contribution to severe gastrointestinal tract dysmotility. | Patients with systemic sclerosis (SSc) complicated by severe gastrointestinal tract (GIT) dysmotility at an early stage are difficult to treat and mortality is high. To clarify the pathogenesis of GIT involvement, the occurrence of autoantibody was investigated for muscarinic-3 acetylcholine receptor (M3R) in patients ... | 18,762,475 |
Bosque: integrated phylogenetic analysis software. | Phylogenetic analyses today involve dealing with computer files in different formats and often several computer programs. Although some widely used applications have integrated important functionalities for such analyses, they still work with local resources only: input/output files (users have to manage them) and loca... | 18,762,483 |
Characteristics that distinguish abusive from nonabusive head trauma among young children who underwent head computed tomography in Japan. | Distinguishing abusive head trauma in young children from other diseases by symptoms is difficult in practice. Comparisons between abusive and nonabusive head trauma in young children in Japan, where computed tomography is widely and easily available, might contribute to identifying markers of abusive head trauma that ... | 18,762,487 |
Food security, maternal stressors, and overweight among low-income US children: results from the National Health and Nutrition Examination Survey (1999-2002). | A high proportion of children in the United States are overweight, suffer from food insecurity, and live in households facing maternal stressors. The objective of this article was to identify the associations of food insecurity and maternal stressors with childhood overweight among low-income children. We hypothesized ... | 18,762,488 |
Safety monitoring of drugs receiving pediatric marketing exclusivity. | The Food and Drug Administration Modernization Act provided for an additional 6-month period of marketing exclusivity to companies that perform pediatric drug trials in response to a Food and Drug Administration-issued written request. Because many safety concerns cannot be detected until after the introduction of a pr... | 18,762,496 |
First successful bone marrow transplantation for X-linked chronic granulomatous disease by using preimplantation female gender typing and HLA matching. | Allogeneic hematopoietic stem cell transplantation from an human leukocyte antigen (HLA)-identical donor is currently the only proven curative treatment for chronic granulomatous disease. Hematopoietic stem cell transplantation with alternative donors is associated with higher morbidity and mortality. Therefore, we per... | 18,762,514 |
Early language outcomes of early-identified infants with permanent hearing loss at 12 to 16 months of age. | The objectives of this study were to determine the early language outcomes of children with mild to profound hearing loss, compared with hearing control children, at 12 to 16 months of age and to examine the effects of "very early" enrollment (</=3 months) in early intervention. This was a prospective longitudinal s... | 18,762,523 |
Values parents apply to decision-making regarding delivery room resuscitation for high-risk newborns. | The aim of this study was to characterize parental decision-making regarding delivery room resuscitation for infants born extremely prematurely or with potentially lethal congenital anomalies. This was a qualitative multicenter study. We identified English-speaking parents at 3 hospitals whose infants had died as a res... | 18,762,529 |
Blood leucocyte telomere DNA content predicts vascular telomere DNA content in humans with and without vascular disease. | Previous studies have suggested that reduced telomere length in circulating leucocytes in humans is associated with premature vascular disease and by implication, accelerated vascular ageing. Importantly, a link between telomere length in circulating leucocytes and the blood vessel wall has never been established. We, ... | 18,762,552 |
Biochemical markers of myocardial remodelling in hypertensive heart disease. | The intricate mechanisms responsible for the structural remodelling of the myocardium that facilitates the evolution to heart failure in hypertensive patients, namely in those with left ventricular hypertrophy, requires from clinicians the utilization of a multibiomarker approach for short-term and long-term stratifica... | 18,762,556 |
Inhibition of specific HDACs and sirtuins suppresses pathogenesis in a Drosophila model of Huntington's disease. | Huntington's disease (HD) is associated with transcriptional dysregulation, and multiple studies with histone deacetylase (HDAC) inhibitors suggest that global approaches for restoring transcriptional balance and appropriate protein acetylation are therapeutically promising. To determine whether more targeted approache... | 18,762,557 |
Use of recombinant human interferon alpha-2a in the management of a dog with epitheliotropic lymphoma. | An 8-year-old, mixed-breed dog with preputial epitheliotropic lymphoma was initially treated with cyclophosphamide, vincristine, and prednisolone. A short-term partial response was followed by disease progression after 4 weeks. Recombinant human interferon alpha-2a was administered starting at week 7. The interferon th... | 18,762,565 |
Recruitment of PCM1 to the centrosome by the cooperative action of DISC1 and BBS4: a candidate for psychiatric illnesses. | A role for the centrosome has been suggested in the pathology of major mental illnesses, especially schizophrenia (SZ). To show that pericentriolar material 1 protein (PCM1) forms a complex at the centrosome with disrupted-in-schizophrenia 1 (DISC1) and Bardet-Biedl syndrome 4 protein (BBS4), which provides a crucial p... | 18,762,586 |
Genomewide association analysis followed by a replication study implicates a novel candidate gene for neuroticism. | Neuroticism is a trait that reflects a tendency toward negative mood states. It has long been linked to internalizing psychiatric conditions, such as anxiety and depression, and it accounts for much of the substantial comorbidity seen between these disorders. To identify common genetic variants that affect neuroticism ... | 18,762,592 |
Depressive symptoms in youth heads of household in Rwanda: correlates and implications for intervention. | To examine the level of depressive symptoms and their predictors in youth from one region of Rwanda who function as heads of household (ie, those responsible for caring for other children) and care for younger orphans. Cross-sectional survey Four adjoining districts in Gigonkoro, an impoverished rural province in south... | 18,762,600 |
Anaphylaxis following quadrivalent human papillomavirus vaccination. | In 2007, Australia implemented the National human papillomavirus (HPV) Vaccination Program, which provides quadrivalent HPV vaccine free to all women aged 12-26 years. Following notification of 7 presumptive cases of anaphylaxis in the state of New South Wales, Australia, we verified cases and compared the incidence of... | 18,762,618 |
Patient risk related to common dental radiographic examinations: the impact of 2007 International Commission on Radiological Protection recommendations regarding dose calculation. | In 2007, the International Commission on Radiological Protection (ICRP) revised estimates of the radiosensitivity of tissues including those in the maxillofacial region. The authors conducted a study to reassess patients' risk related to common dental radiographic exposures using the 2007 ICRP recommendations. The auth... | 18,762,634 |
Dentists in double trouble: the (un)fairness of punishing for the same mistake twice. | and Overview. Many state dental practice acts allow for the suspension or revocation of a dentist's license on the basis of a previous conviction for illegal behavior, even if the behavior is not related to the practice of dentistry. Penalizing a dentist twice for the same behavior appears to violate the legal principl... | 18,762,636 |
Total hip replacement in patients eighty years of age and older. | The number of people eighty years of age and older in developed countries is increasing, with a concomitant increased demand for total hip replacement. We analyzed the outcomes of total hip arthroplasty for patients in this age group using data from the Finnish National Arthroplasty Registry. Data from the Finnish Arth... | 18,762,648 |
Interlocking contoured intramedullary nail fixation for selected diaphyseal fractures of the forearm in adults. | Plate osteosynthesis is the most commonly used technique for the treatment of diaphyseal forearm fractures in adults. However, application of a plate can disrupt the periosteal blood supply and necessitates skin incisions that may be unsightly, and there is a risk of refracture if the implant is removed. The purpose of... | 18,762,649 |
Traumatic anterosuperior rotator cuff tears: the outcome of open surgical repair. | Anterosuperior rotator cuff tears involving the subscapularis and supraspinatus tendons are less common than posterosuperior tears and are rarely discussed in the literature. The purpose of this study was to identify the unique features of this injury and to assess the outcome of operative treatment. Thirty consecutive... | 18,762,651 |
Computerized tomographic morphometric analysis of subaxial cervical spine pedicles in young asymptomatic volunteers. | Although cervical spine pedicle screws have been shown to provide excellent fixation, widespread acceptance of their use is limited because of the risk of injury to the spinal cord, nerve roots, and vertebral arteries. The risks of pedicle screw insertion in the cervical spine can be mitigated by a three-dimensional ap... | 18,762,652 |
Linked elbow replacement: a salvage procedure for distal humeral nonunion. | Nonunion is a challenging and not uncommon complication of distal humeral fractures. Our long-term experience with linked semiconstrained total elbow arthroplasty as a salvage procedure for patients with distal humeral nonunion not amenable to internal fixation was investigated. Ninety-one consecutive patients (ninety-... | 18,762,655 |
Arthroscopic surgery for primary traumatic patellar dislocation: a prospective, nonrandomized study comparing patients treated with and without acute arthroscopic stabilization with a median 7-year follow-up. | No data exist whether patients with primary traumatic patellar dislocation benefit from initial arthroscopic medial repair surgery. To compare long-term outcomes of patients treated with acute arthroscopic stabilization for patellar dislocation with those treated nonoperatively except for removal of loose bodies. Cohor... | 18,762,668 |
Amplatzer device closure of a tortuous Gerbode (left ventricle-to-right atrium) defect complicated by transient hemolysis in an octogenarian. | An 86 year-old male presented with progressive shortness of breath and a murmur. Six years earlier, he had undergone mitral valve surgery. An echocardiogram revealed a significant left ventricular-to-right atrial connection (Gerbode defect). The defect was closed percutaneously using an Amplatzer Septal Occluder device... | 18,762,687 |
Large somatostatin-producing endocrine carcinoma of the ampulla of vater in association with GIST in a patient with von Recklinghausen's disease. Case report and review of the literature. | Somatostatin-producing endocrine tumors of the duodenum are very rare neoplasms of the gastrointestinal tract. These tumors may be associated with von Recklinghausen's disease. We present the case of a 49-year-old female patient with von Recklinghausen's disease and an incidentally diagnosed ampullary neoplasm. The pat... | 18,762,695 |
Heterotopic ileal pancreas with lipoma and coexisting fibromatosis associated with a rare case of gastrointestinal bleeding. A case report and review of the literature. | The development of pancreatic tissue outside the confines of the main gland represents a congenital abnormality referred to as heterotopic pancreas. This is a rare pathological and surgical entity which remains mostly asymptomatic. We present the case of a 28-year-old male, who was admitted to hospital because of a his... | 18,762,696 |
Impact of genetic polymorphisms of transporters on the pharmacokinetic, pharmacodynamic and toxicological properties of anionic drugs. | As the importance of drug transporters in the clinical pharmacokinetics of drugs is recognized, genetic polymorphisms of drug transporters have emerged as one of the determinant factors to produce the inter-individual variability of pharmacokinetics. Many clinical studies have shown the influence of genetic polymorphis... | 18,762,709 |
L-type fatty acid binding protein transgenic mouse as a novel tool to explore cytotoxicity to renal proximal tubules. | A novel biomarker of renal dysfunction, liver-type fatty acid binding protein (L-FABP), which is expressed in human proximal tubules, binds to lipid peroxidation products during renal injury and is excreted into the urine. Here, we examined the usefulness of human L-FABP transgenic (Tg) mice as a tool to explore nephro... | 18,762,714 |
Role of Na+/L-carnitine transporter (OCTN2) in renal handling of pivaloylcarnitine and valproylcarnitine formed during pivalic acid-containing prodrugs and valproic acid treatment. | Pivalic acid and valproic acid decreases L-carnitine concentration in the body via urinary excretion of their acylcarnitines, pivaloylcarnitine (PC) and valproylcarnitine (VC). To obtain an information about the mechanism of the physiological response, we investigated the renal handling of these acylcarnitines by Na+/L... | 18,762,717 |
The effects of prolactin and gonadotropin on luteal function and morphology in the cyclic golden hamster. | The present study was conducted to evaluate the endocrinological effects of the pituitary on luteal maintenance and regression in the cyclic golden hamster (Mesocritus auratus). After hypophysectomy (Hypox) at 0900 h on day 1 of the estrous cycle (the day of ovulation), the animals received injection of prolactin (PRL)... | 18,762,720 |
Lack of association between the dopamine transporter gene 3' VNTR polymorphism and attention deficit hyperactivity disorder in Chinese Han children: case-control and family-based studies. | Attention deficit hyperactivity disorder (ADHD) is the most common childhood onset neurodevelopment disorder. The etiology is unclear, but is suspected to involve the dopamine system. In this study we used the haplotype-based haplotype relative risk (HHRR) analysis and the transmission disequilibrium test (TDT) to inve... | 18,762,727 |
Reversal effects of Ca2+ antagonists on multidrug resistance via down-regulation of MDR1 mRNA. | In previous reports, the effects of 12 Ca2+ antagonists on a multidrug resistant transporter, P-glycoprotein/MDR1, were evaluated in terms of those on MDR1-mediated transport of [3H]digoxin and the sensitivity of vinblastine sulfate or paclitaxel, and they were able to be classified into 4 subgroups based on their acti... | 18,762,730 |
Acute effects of angiotensin II receptor blocker on ventricular repolarization alternans in chronic heart failure. | Repolarization alternans, which can be detected clinically as microvolt-level T-wave alternans (TWA), is considered an important mechanism underlying the initiation of ventricular tachycardia/ventricular fibrillation (VT/VF) linked to sudden cardiac death (SCD). Recently, the rennin-angiotensin system (RAS) inhibitors ... | 18,762,731 |
The International Classification of Functioning Disability and Health: its development process and content validity. | The World Health Organization's International Classification of Functioning, Disability and Health (ICF) has provided a new foundation for our understanding of health, functioning, and disability. However, different challenges have to be addressed during its implementation process. The objective of this paper is to add... | 18,762,740 |
Efficacy of imatinib mesylate in the treatment of refractory sclerodermatous chronic GVHD. | Treatment of sclerodermatous chronic GVHD (cGVHD) remains disappointing. Imatinib mesylate enables selective, dual inhibition of the transforming growth factor beta (TGFbeta) and PDGF pathways. Recently, the drug's effects on fibroblasts have been reported in both in vitro and in vivo studies. The inhibition of fibrobl... | 18,762,765 |
Lapatinib therapy for patients with advanced renal cell carcinoma. | Lapatinib is an oral dual inhibitor of EGFR and HER2, the coexpression of which is associated with metastatic disease in patients with renal cell carcinoma. A recent randomized phase III trial of lapatinib versus hormone therapy was conducted in patients with cytokine-refractory metastatic renal cell carcinoma and tumo... | 18,762,792 |
The atypical Rho GTPase RhoBTB2 is required for expression of the chemokine CXCL14 in normal and cancerous epithelial cells. | The Rho family of small GTPases control cell migration, cell invasion and cell cycle. Many of these processes are perturbed in cancer and several family members show altered expression in a number of tumor types. RhoBTB2/DBC2 is an atypical member of this family of signaling proteins, containing two BTB domains in addi... | 18,762,809 |
Osteogenic differentiation of rat mesenchymal stem cells from adipose tissue in comparison with bone marrow mesenchymal stem cells: melatonin as a differentiation factor. | Adipose-derived stem cells (ADSC) could be an appealing alternative to bone marrow stem cells (BMSC) for engineering cell-based osteoinductive grafts. Meanwhile, prior studies have demonstrated that melatonin can stimulate osteogenic differentiation. Therefore, we assayed and compared the melatonin effect on osteogenic... | 18,762,816 |
The chemistry of gold as an anion. | Due to relativistic and classical shell structure effects, the 6s orbital of gold is significantly contracted and energetically stabilized. This is reflected by a strikingly high electron affinity, and a distinct tendency to adopt negatively polarized valence states. This tutorial review focuses on the chemistry of gol... | 18,762,832 |
The use of gold nanoparticles in diagnostics and detection. | The widespread use of gold nanoparticles (GNPs) as labels in diagnostics and detection is due to a unique combination of chemical and physical properties that allow biological molecules to be detected at low concentrations. In this critical review detection methods based on GNPs are divided up and discussed based on th... | 18,762,845 |
Supported gold nanoparticles as catalysts for organic reactions. | This critical review is intended to attract the interest of organic chemists and researchers on green and sustainable chemistry on the catalytic activity of supported gold nanoparticles in organic transformations. In the general part of this critical review, emphasis is given to the different procedures to form support... | 18,762,848 |
Catalysis by gold dispersed on supports: the importance of cationic gold. | There are many examples of catalysis in solution by cationic complexes of gold, and recent results, reviewed here in this critical review, demonstrate that cationic gold species on oxide and zeolite supports are also catalytically active, for reactions including ethylene hydrogenation and CO oxidation. The catalyticall... | 18,762,849 |
A simple method for amino acid selective isotope labeling of recombinant proteins in E. coli. | A simple and user-friendly method of labeling protein selectively with amino acids in vivo is introduced. This technique does not require the use of transaminase-deficient or auxotrophic strains. By manipulating the product feedback inhibitory loops of the E. coli amino acid metabolic pathways and, if necessary, by usi... | 18,762,866 |
Characterization of S1 nuclease sensitive site at transcription initiation region of Attacus ricini rDNA. | A single-stranded S1 nuclease hypersensitive site which contains a d(AT)(18) sequence structure located in the 5'-non transcription spacer of silkworm A. ricini ribosomal RNA gene has been reported([1]). Using starved-refed silkworms, another S1 nuclease sensitive site was found existing in the rDNA chromatin, while un... | 18,762,880 |
Simultaneous bilateral opening-wedge high tibial osteotomy with early full weight-bearing exercise. | Simultaneous bilateral opening-wedge high tibial osteotomies (OWHTOs), using the TomoFix fixation device and artificial bone wedges (beta-TCP) were performed on 20 knees of 10 patients with an average age of 67 years (range 53-75) at the time of the operation. We established an early weight-bearing exercise program dur... | 18,762,910 |
Comparison of the bioabsorbable and metal screw fixation after ACL reconstruction with a hamstring autograft in MRI and clinical outcome: a prospective randomized study. | There has never been an MRI study of tunnel widening comparing bioabsorbable to metal screw fixation in autologous hamstring anterior cruciate ligament (ACL) reconstruction. We randomized 62 patients to hamstring ACL reconstruction with either a bioabsorbable (n=31) or metal screw (n=31) fixation. The evaluation method... | 18,762,911 |
Cross-modal plasticity for the spatial processing of sounds in visually deprived subjects. | Until only a few decades ago, researchers still considered sensory cortices to be fixed or "hardwired," with specific cortical regions solely dedicated to the processing of selective sensory inputs. But recent evidences have shown that the brain can rewire itself, showing an impressive range of cross-modal plasticity. ... | 18,762,928 |
Non-classical hereditary hemochromatosis in Portugal: novel mutations identified in iron metabolism-related genes. | The most frequent genotype associated with Hereditary hemochromatosis is the homozygosity for C282Y, a common HFE mutation. However, other mutations in HFE, transferrin receptor 2 (TFR2), hemojuvelin (HJV) and hepcidin (HAMP) genes, have also been reported in association with this pathology. A mutational analysis of th... | 18,762,941 |
Protective effect of trapidil on long-term histologic damage in a rat model of testicular ischemia-reperfusion injury. | Trapidil is an antianginal compound with a broad spectrum of pharmacological activities. In recent years, it has been used successfully to decrease ischemia-reperfusion injury in several organ systems. We evaluated the effect of trapidil on the long-term histologic damage in testicular ischemia-reperfusion injury. Adul... | 18,762,946 |
Activation of big conductance Ca(2+)-activated K (+) channels (BK) protects the heart against ischemia-reperfusion injury. | Activation of the large-conductance Ca(2+)-activated K(+) channel (BK) in the cardiac inner mitochondrial membrane has been suggested to protect the heart against ischemic injury. However, these findings are limited by the low selectivity profile and potency of the BK channel activator (NS1619) used. In the present stu... | 18,762,970 |
Evaluation of the relative importance of chemotherapeutic and antiemetic efficacy in various oncologic settings. | This study investigated physician's attitudes toward the relative importance of chemotherapeutic and antiemetic efficacy in different clinical scenarios. Oncologists in the USA and four European countries completed an online stated-choice survey consisting of three hypothetical treatment choices for each of two patient... | 18,762,991 |
Proinflammatory cytokine gene polymorphisms among Iranian patients with asthma. | Asthma is one of the most common respiratory diseases caused by acute and chronic inflammation of airways. Proinflammatory cytokines could contribute to this inflammatory process. This study was performed in order to analyze the genetic profile of proinflammatory cytokines in Iranian asthmatic patients. The allele and ... | 18,763,028 |
Family history is a significant risk factor for pancreatic cancer: results from a systematic review and meta-analysis. | Epidemiologic evidence suggests a family history of pancreatic cancer (PC) is a risk factor for the disease, yet the magnitude of risk varies between studies. We performed a systematic review of studies that quantified familial risks of PC, and through a meta-analysis, obtained more precise estimates of familial risk. ... | 18,763,055 |
Heat-shock response protects peripheral blood mononuclear cells (PBMCs) from hydrogen peroxide-induced mitochondrial disturbance. | The present study was designed to investigate ex vivo the protective mechanisms of heat-shock response against H(2)O(2)-induced oxidative stress in peripheral blood mononuclear cells (PBMCs) of rats. Twenty-four hours later, heat-shock treatment was executed in vivo; rat PBMCs were collected and treated with H(2)O(2). ... | 18,763,057 |
Molecular mechanism of signaling by tumor necrosis factor. | Tumor necrosis factor (TNF) is an important cytokine with multiple biological effects, including cell growth, differentiation, apoptosis, immune regulation and induction of inflammation. The effects of TNF are mediated by two receptors, TNF-R1 and TNF-R2. The major signal transduction pathways triggered by TNF include ... | 18,763,070 |
Opening angles and residual strains in normal rat trachea. | The no-load state and zero-stress state of the normal rat trachea were analyzed. It was found that there exist compressive residual strains in the inner wall region of the rat trachea and tensile residual strains in the outer wall region. The fact that the opening angle of the rat trachea cut at the cartilaginous regio... | 18,763,073 |
Amylin evokes protein p20 phosphorylation and insulin resistance in rat skeletal muscle extensor digitorum longus. | In the present study, we investigate effect of amylin on the insulin sensitivity of rat skeletal muscle extensor digitorum longus (EDL) using in vitro intact muscle incubation in combination with metabolic radioactive labeling. The molecular basis of the amylin action was further examined using proteomic analysis. In p... | 18,763,075 |
Constitutive expression of human coagulating factor IX in HeLa cells by homologous recombination of the promoter. | Constitutive expression of hFIX protein in nonhepatocytes was studied. The gene targeting vector was constructed and transferred into HeLa cells. With the detection system of PCR, we demonstrated that the endogenoushFIX promoter was replaced with anhCMV promoter when targeted insertion of the constructor was directed b... | 18,763,084 |
Binocular fusion in Panum's limiting case of stereopsis obeys the uniqueness constraint. | In the information processing procedure of stereo vision, the uniqueness constraint has been used as one of the constraints to solve the "correspondence problem". While the uniqueness constraint is valid in most cases, whether it is still valid in some particular stimulus configuration (such as Panum's limiting case) h... | 18,763,087 |
Study of rat neuronal genes with ordered differential display method. | Ordered differential display (ODD) was developed recently and has been applied to systematic comparison of expression profiles of genes. It was further improved with the specific complexing property between biotin and streptavidin by the authors. First, random primer and biotinylated oligo (dT) primer were used to make... | 18,763,101 |
Activity identification of chimeric anti-caspase-3 mRNA hammerhead ribozyme in vitro and in vivo. | To study the expression activity of various vectors containing anti-caspase-3 ribozyme cassettes in vivo, and to further study the role of caspas-3 in the apoptotic pathway, we constructed anti-caspase-3 hammerhead ribozyme embedded into the human snRNA U6, and detected the activity of the ribozyme in vitro and in vivo... | 18,763,103 |
The uplift of Qinghai-Xizang (Tibet) Plateau and the vicariance speciation of glyptosternoid fishes (Siluriformes: Sisoridae). | Based on the phylogenetic and biogeographical studies of the glyptosternoid fishes in Qinghai-Tibet area, the following hypothesis is proposed: the speciation of this group has a direct relationship with the three uplift intervals of the Qinghai-Tibet Plateau. This process was explained by the theory of vicariance of b... | 18,763,106 |
The human apoE7 and apoE4 transgenic mice models. | To scrutinize the disorders caused by human mutant apoE7/apoE4, human apoE4 and E7 transgenic mice were established with microinjection technique to examine molecular genetic phenomena in vivo. The integration and expression of h-apoE mutant genes in transgenic mice were determined with Southern blot, Northern blot and... | 18,763,107 |
Effect of different immunosuppressive drugs on calcineurin and its mutants. | Several mutants in Loop7 region and near Loop7 region of calcineurin A (CN A) subunit have been constructed and purified using site-directed mutagenesis. Their phosphatase activity and the corresponding solution conformation were examined. Their phosphatase activities between wild-type CN and mutants were compared to i... | 18,763,117 |
Structural feature of sorghum chloroplastpsbA gene and regulation effects of its 5'-noncoding region. | Comparative analysis reveals remarkahle homology between the sequences of bothpsbA gene nucleotides and the inferred amino acids of sorghum, a C(4) plant, and those of rice, a C(3) plant. The 5'-noncoding region of sorghumpsbA gene contains the conservative promoter elements, "-35" element and "-10" element, like the p... | 18,763,129 |
Effect of DNA binding protein Ssh12 from hyperthermophilic archaeonSulfolobus shibatae on DNA supercoiling. | An 11.5-ku DNA binding protein, designated as Ssh12, was purified from the hyperthermophilic archaeonSulfolobus shibatae by column chromatography in SP Sepharose, DNA cellulose and phosphocellulose. Ssh12 accounts for about 4 % of the total cellular protein. The protein is capable of binding to both negatively supercoi... | 18,763,131 |
ESI-MS study on non-covalent bond complex of rhFKBP12 and new neurogrowth promoter. | An ESI-MS method for studying the non-covalent bond complex of rhFKBP12 with its nonimmunosuppressive ligands was developed. The method was used to screen out three compounds capable of binding to rhFKBP12 non-covalently from 52 compounds. By competing binding experiment, the binding site and the relative binding stren... | 18,763,143 |
Effects of TFAR19 gene on the growth and biorheological properties of mouse erythroleukemia cell line MEL. | Using the method of gene transfection with liposome, we obtained the mouse erythroleukemia cell line MEL-TF19, which stably carries TFAR19, a novel apoptosis-related gene. The expression of TFAR19 was detected by Western blot. Growth curve and flow cytometry analysis showed that after being transfected with TFAR19 gene... | 18,763,144 |
Effects of simulated microgravity on nitric oxide level in cardiac myocytes and its mechanism. | The depression of cardiac contractility induced by space microgravity is an important issue of aerospace medicine research, while its precise mechanism is still unknown. In the present study, we explored effects of simulated microgravity on nitric oxide (NO) level, inducible nitric oxide synthase (iNOS) expression and ... | 18,763,145 |
Inhibition of human poly(A)-specific ribonuclease (PARN) by purine nucleotides: kinetic analysis. | Poly(A)-specific ribonuclease (PARN) is a cap-interacting and poly(A)-specific 3'-exoribonuclease that efficiently degrades mRNA poly(A) tails. Based on the enzyme's preference for its natural substrates, we examined the role of purine nucleotides as potent effectors of human PARN activity. We found that all purine nuc... | 18,763,168 |
Drug discovery and development for Huntington's disease - an orphan indication with high medical need. | Huntington's disease (HD) is a rare neurodegenerative disorder that progressively destroys the mental capacity and motor control of patients. This loss of motor control results in abnormal body movements (chorea) - the hallmark of HD. Given that no disease-modifying therapy for HD exists and that available symptomatic ... | 18,763,216 |
Standardized remission criteria in schizophrenia: descriptive validity and comparability with previously used outcome measures. | Standardized consensus criteria for remission in schizophrenia were recently proposed. As yet, the validity of these criteria and their comparability with previously used outcome measures are unclear. The symptom-severity component of the proposed remission criteria was applied to 288 inpatients who fulfilled the ICD-1... | 18,763,221 |
[Contrast enhanced endosonography for improving differential diagnosis between chronic pancreatitis and pancreatic cancer]. | The aim of this study was to evaluate contrast-enhanced endosonography as a method for improving the differentiation between chronic focal pancreatitis and ductal pancreatic cancer, based on perfusion characteristics of the microcirculation. In 194 patients [75 women, 119 men; age: 64 +/- 11 years] with chronic pancrea... | 18,763,228 |
Rapid and sensitive analysis of multiple bioactive constituents in Compound Danshen preparations using LC-ESI-TOF-MS. | By fully optimizing the separation and analytical conditions, a rapid-resolution LC (RRLC, 1.8 microm particle size) coupled with TOF-MS method was developed and validated for multiple compounds analysis of traditional Chinese medicinal compound preparations (TCMCPs). As a typical example, determination of Compound Dan... | 18,763,250 |
The panel of egg allergens, Gal d 1-Gal d 5: Their improved purification and characterization. | Egg proteins represent one of the most important sources evoking food allergic reactions. In order to improve allergy diagnosis, purified and well-characterized proteins are needed. Although the egg white allergens Gal d 1, 2, 3 and 4 (ovomucoid, ovalbumin, ovotransferrin, and lysozyme) are commercially available, thes... | 18,763,254 |
Real-time, on-line monitoring of organic chemical reactions using extractive electrospray ionization tandem mass spectrometry. | Extractive electrospray ionization mass spectrometry (EESI-MS) for real-time monitoring of organic chemical reactions was demonstrated for a well-established pharmaceutical process reaction and a widely used acetylation reaction in the presence of a nucleophilic catalyst, 4-dimethylaminopyridine (4-DMAP). EESI-MS provi... | 18,763,264 |
Urinary metabolic profile of 19-norsteroids in humans: glucuronide and sulphate conjugates after oral administration of 19-nor-4-androstenediol. | 19-Nor-4-androstenediol (NOL) is a prohormone of nandrolone (ND). Both substances are included in the WADA List of Prohibited Classes of Substances and their administration is determined by the presence of 19-norandrosterone (NA) with the urinary threshold concentration of 2 ng mL(-1). Routine analytical procedures all... | 18,763,272 |
Treatment of polycystic liver disease with resection-fenestration and a new classification. | To evaluate outcomes in patients with autosomal dominant polycyst liver disease (APLD) treated by combined hepatic resection and fenestration. A new classification was recommended to presume postoperative complications and long outcome of patients. Twenty-one patients with APLD were treated by a combined hepatic resect... | 18,763,291 |
Preliminary studies on the chemical characterization and antioxidant properties of acidic polysaccharides from Sargassum fusiforme. | In order to investigate the antioxidant properties of the polysaccharides from the brown alga Sargassum fusiforme, the crude polysaccharides from S. fusiforme (SFPS) were extracted in hot water, and the lipid peroxidation inhibition assay exhibited that SFPS possessed a potential antioxidant activity. Hence, two purely... | 18,763,305 |
Using Google Earth as an innovative tool for community mapping. | Maps are used to track diseases and illustrate the social context of health problems. However, commercial mapping software requires special training. This article illustrates how nonspecialists used Google Earth, a free program, to create community maps. The Bronx, New York, is characterized by high levels of obesity a... | 18,763,409 |
Maternal obesity and risk of infant death based on Florida birth records for 2004. | The purpose of this study was to assess the relationship between pre-pregnancy maternal obesity and risk of infant death. In March 2004, maternal height and pre-pregnancy weight were added to the data collected on the Florida birth certificate. Using birth records linked to infant deaths, these data were used to assess... | 18,763,411 |
Receiver operating characteristics for the brief symptom inventory depression, paranoid ideation, and psychoticism scales in a large sample of clinical inpatients. | A commonly used screening tool for psychopathology, the Brief Symptom Inventory, provides normative data for assessing current mental functioning across multiple domains. Using data from 654 psychiatric inpatients, receiver operating characteristic (ROC) analyses were conducted for three scales, Depression, Paranoid Id... | 18,763,438 |
Attractive but guilty: deliberation and the physical attractiveness bias. | The current study examined the effect of jury deliberation on the tendency for mock jurors to find attractive defendants guilty less often. It was expected that there would be an interaction between group deliberation (yes or no) and defendant's appearance (plain-looking or attractive). It was hypothesized that mock ju... | 18,763,443 |
Women and suicide in Islamic sub-Saharan Africa. | Research on suicide among Islamic women in sub-Saharan Africa was reviewed. The few reports available do not specify the ethnicity and religious affiliation of the cases, making interpretation of the reports difficult. | 18,763,444 |
Insubordination and genius: Galileo, Darwin, Pasteur, Einstein, and Pauling. | This essay examines the lives of five great scientists who contributed enormously to mankind. Although their lives were vastly different, they all trod a final common pathway in securing scientific breakthroughs. These were stubborn, egotistical, tenacious, work-oriented people who could not be deterred by obstacles of... | 18,763,453 |
Skin conductance as an indicator of anticipated concealed knowledge. | The present study investigated the effects of anticipation on skin conductance while participants were answering a set of questions which included one of concealed knowledge. Two experiments were conducted. In Exp. 1, 26 participants completed one experimental session. Each participant was asked to choose one two-digit... | 18,763,466 |
[Ionic chemistry in snowpits from Yamzhog Yumco Basion]. | During August and September, 2006, a total of 50 samples had been collected from three different snowpits at the Yamzhog Yumco Basion in the south of the Tibetan Plateau. All samples were analyzed for major cations (Na+, NH4+, K+, Ca2+ and Mg2+), anions (Cl-, SO4(2-) and NO3-) and stable oxygen isotope ratio. The resul... | 18,763,489 |
[Effect and mechanism of heavy metal stabilization treatment of sediment in Jinshan Lake]. | The heavy metal stabilization treatment (by mixture of CaO, CaO2, CaO and CaO2) of sediment in Jinshan Lake were investigated through soil column experiment, including the transport and transformation of heavy metal in sediment after stabilization, and the mechanism of heavy metal stabilization treatment technology. In... | 18,763,527 |
[Preparation of Cu/ZrO2/S2O8(2-)/gamma-Al2O3 solid acid catalyst and its catalytic activity to selective reduction of NO]. | Cu/ZrO2/S2O8(2-)/gamma-Al2O3 solid acid catalyst was prepared by loading of (NH4)2S2O8, ZrOCl2, and Cu(NO3)2 onto gamma-Al2O3 step by step, which was obtained from calcining of pseudoboehmite. The catalytic property of Cu/ZrO2/S2O8(2-)/gamma-Al2O3 on the selective reduction of NO by C3H6 in excess oxygen was investigat... | 18,763,532 |
Shallow groundwater nitrogen responses to different land use managements in the riparian zone of Yuqiao Reservoir in North China. | This field study investigated the nitrogen concentrations in the shallow groundwater from an ephemeral stream and four land uses: cropland, two-year restored (2 yr) and five-years restored (5 yr) woodlands, fishponds, and the nitrogen flux in the riparian zone of Yuqiao Reservoir. The groundwater nitrate-N concentratio... | 18,763,557 |
Patient rehabilitation following lower limb amputation. | Patient rehabilitation following lower limb amputation is essential to provide optimum patient outcomes and to improve the amputee's quality of life. The age of the patient and the stump length or level of amputation emerge as dominant factors affecting the outcome of rehabilitation. A variety of outcome measures are a... | 18,763,548 |
[Peculiarities of stress-reactivity of hypothalamo-pituitary-adrenal system in prenatally stressed rats exposed to dexamethasone]. | The protective effect of dexamethasone, a synthetic agonist of glucocorticoids, on the functional activity of hypothalamo-pituitary-adrenal system (HPAS) in adult offspring in both genders whose mothers were subject to immobilization stress in last trimester of pregnancy, has been studied. Dexamethasone treatment prior... | 18,763,576 |
[Age-related aspects of intestinal microflora and the intestinal immune system]. | The importance of influence of microorganisms on human health has been recognized for years. Vast amount of data has been collected regarding interaction of intestinal microflora and elements of gut immune system. Novel technologies are offering new insights into bi-directional host-flora exchange along mucosal surface... | 18,763,586 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.