title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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X-ray absorption measured in the resonant Auger scattering mode. | We report both experimental and theoretical studies on x-ray absorption measured in the resonant Auger scattering mode of gas phase carbon monoxide near the O1s-->2pi region. Both experiment and theory display a crucial difference between the x-ray absorption profiles obtained in the conventional and resonant scatte... | 18,764,527 |
Monotonic convergent optimal control theory with strict limitations on the spectrum of optimized laser fields. | We present a modified optimal control scheme based on the Krotov method, which allows for strict limitations on the spectrum of the optimized laser fields. A frequency constraint is introduced and derived mathematically correct, without losing monotonic convergence of the algorithm. The method guarantees a close link t... | 18,764,528 |
Recoil-ion momentum distributions for two-photon double ionization of He and Ne by 44 eV free-electron laser radiation. | Recoil-ion momentum distributions for two-photon double ionization of He and Ne (variant Planck's over omega=44 eV) have been recorded with a reaction microscope at FLASH (the free-electron laser at Hamburg) at an intensity of approximately 1 x 10(14) W/cm2 exploring the dynamics of the two fundamental two-photon-two-e... | 18,764,529 |
Suppression of inelastic collisions between polar molecules with a repulsive shield. | We propose and analyze a technique that allows one to suppress inelastic collisions and simultaneously enhance elastic interactions between cold polar molecules. The main idea is to cancel the leading dipole-dipole interaction with a suitable combination of static electric and microwave fields in such a way that the re... | 18,764,530 |
Optical near-field microscopy of light focusing through a photonic crystal flat lens. | We report here the direct observation by using a scanning near-field microscopy technique of the light focusing through a photonic crystal flat lens designed and fabricated to operate at optical frequencies. The lens is fabricated using a III-V semiconductor slab, and we directly visualize the propagation of the electr... | 18,764,535 |
Short-scale turbulent fluctuations driven by the electron-temperature gradient in the national spherical torus experiment. | Measurements with coherent scattering of electromagnetic waves in plasmas of the National Spherical Torus Experiment indicate the existence of turbulent fluctuations in the range of wave numbers k perpendicular rho(e)=0.1-0.4, corresponding to a turbulence scale length nearly equal to the collisionless skin depth. Expe... | 18,764,544 |
Interaction of streamer discharges in air and other oxygen-nitrogen mixtures. | The interaction of streamers in nitrogen-oxygen mixtures such as air is studied. First, an efficient method for fully three-dimensional streamer simulations in multiprocessor machines is introduced. With its help, we find two competing mechanisms how two adjacent streamers can interact: through electrostatic repulsion ... | 18,764,548 |
Breakdown of the two-step model in K-shell photoemission and subsequent decay probed by the molecular-frame photoelectron angular distributions of CO2. | We report results of measurements and of Hartree-Fock level calculations of molecular-frame photoelectron angular distributions (MFPADs) for C 1s photoemission from CO2. The agreement between the measured and calculated MFPADs is on average reasonable. The measured MFPADs display a weak but definite asymmetry with resp... | 18,764,609 |
Imaging intramolecular coulomb repulsions in multiply charged anions. | The properties of multiply charged anions are dominated by intramolecular Coulomb repulsion (ICR). Using photoelectron imaging, we show the effect of ICR on photoelectron angular distributions for a series of dianions, -O2C(CH2)_{n}CO_{2};{-} (D_{n};{2-}). The observed photoemission band of D_{n};{2-} was due to a perp... | 18,764,611 |
Microfluidic colloidal island formation and erasure induced by surface acoustic wave radiation. | Spatiotemporal patterns form in many nonlinear physicochemical or biological systems. Although unusual, microfluidic systems are no exception. We observe such patterns to form by colloids along the free surface of a drop beneath which surface acoustic waves propagate, and propose fundamental mechanisms to elucidate the... | 18,764,621 |
Direct mapping of phonon dispersion relations in copper by momentum-resolved x-ray calorimetry. | We have developed a new method of mapping phonon dispersion relations based on momentum-resolved x-ray calorimetry. X-ray scattering intensities are measured at selected points in reciprocal space with suitably chosen polarization configurations; the thermal part of the scattering intensity is extracted by scanning the... | 18,764,635 |
Optimal capping layer thickness for stacked quantum dots. | We study the effect of strain on the vertical and lateral self-organization of nanoscale patterns and stacked quantum dots during epitaxial growth. The computational approach is based on the level set method in combination with an atomistic strain code. Strain changes the energetics of microscopic parameters during gro... | 18,764,641 |
Spin-charge separation in the quantum spin Hall state. | The quantum spin Hall state is a topologically nontrivial insulator state protected by the time-reversal symmetry. We show that such a state always leads to spin-charge separation in the presence of a pi flux. Our result is generally valid for any interacting system. We present a proposal to experimentally observe the ... | 18,764,648 |
Strontium ranelate for the management of osteoporosis. | To evaluate the role of strontium ranelate in the management of osteoporosis. A MEDLINE (January 1966 to May 2007) search using the terms osteoporosis, strontium ranelate, bonemineral density, and fractures. All English-language articles identified from the data sources were evaluated. Strontium ranelate stimulates bon... | 18,764,671 |
Evaluation of the effect of ranitidine on gastroduodenal contractile activity and gastric emptying in horses. | To determine the effect of ranitidine on gastric emptying in horses. 11 adult horses. In vitro, isolated muscle strips from the pyloric antrum and duodenum of 5 horses were suspended in baths and attached to isometric force transducers. Once stable spontaneous contractions were observed, ranitidine or diluent was added... | 18,764,686 |
Effect of colostrum administration by use of oroesophageal intubation on serum IgG concentrations in Holstein bull calves. | To determine the amount of colostral IgG required for adequate passive transfer in calves administered colostrum by use of oroesophageal intubation and evaluate the impact of other factors on passive transfer of colostral immunoglobulins in calves. 120 Holstein bull calves. Calves were randomly assigned to specific tre... | 18,764,687 |
Comparison of four methods to assess colostral IgG concentration in dairy cows. | To determine sensitivity and specificity of 4 methods to assess colostral IgG concentration in dairy cows and determine the optimal cutpoint for each method. Cross-sectional study. 160 Holstein dairy cows. 171 composite colostrum samples collected within 2 hours after parturition were used in the study. Test methods us... | 18,764,714 |
Emerging drugs for treatment of overactive bladder and detrusor overactivity. | Overactive bladder (OAB) signifies the presence of urinary urgency and can have major effects on quality of life and social functioning. Standard antimuscarinic drugs have good initial response rates but substantial adverse effects and long-term compliance problems. To review the complexities of the mechanisms underlyi... | 18,764,721 |
Emerging drugs for ovarian cancer. | Long-term survival of patients with ovarian cancer remains poor and therapy disappointing despite decades of experience with various chemotherapies, including the current gold standard, carboplatin/paclitaxel (TC). To review current and emerging therapies for ovarian cancer in search of ways to improve outcome, reduce ... | 18,764,727 |
Locking solutions for hemodialysis catheters; heparin and citrate--a position paper by ASDIN. | There is wide variation in the use of solutions to "lock" or fill tunneled central venous catheters for dialysis. Some centers use undiluted heparin concentrations ranging from 1000 to 10,000 U/ml and other centers place from 1000 to 10,000 U per lumen. Based on available evidence, it appears that heparin 1000 U/ml, or... | 18,764,795 |
Pain experience and the imagined researcher. | Little attention has been paid to what happens communicatively when members of the general population attempt to complete a postal survey. The questions - here, on the experience of pain - encapsulate health researchers' views of useful indicators of the scope of pain experience, hence displaying an 'official' represen... | 18,764,806 |
Is regression of left ventricular hypertrophy in maintenance hemodialysis patients possible? | Left ventricular hypertrophy (LVH), present in 70-80% of patients at the start of dialysis, results from chronic high blood pressure, volume overload, or both, in association with a number of metabolic and neurohumoral alterations. LVH is associated with poor outcome and was considered irreversible until the end of the... | 18,764,802 |
Development of an ELA-DRA gene typing method based on pyrosequencing technology. | The polymorphism of equine lymphocyte antigen (ELA) class II DRA gene had been detected by polymerase chain reaction-single-strand conformational polymorphism (PCR-SSCP) and reference strand-mediated conformation analysis. These methodologies allowed to identify 11 ELA-DRA exon 2 sequences, three of which are widely di... | 18,764,814 |
The syntaxins SYP31 and SYP81 control ER-Golgi trafficking in the plant secretory pathway. | Overexpression of the Golgi and endoplasmic reticulum (ER) syntaxins SYP31 and SYP81 strongly inhibits constitutive secretion. By comparing the secreted reporter alpha-amylase with the ER-retained reporter alpha-amylase-HDEL, it was concluded that SYP81 overexpression inhibits both retrograde and anterograde transport,... | 18,764,818 |
A PDZ-binding motif controls basolateral targeting of syndecan-1 along the biosynthetic pathway in polarized epithelial cells. | The cell surface proteoglycan, syndecan-1, is essential for normal epithelial morphology and function. Syndecan-1 is selectively localized to the basolateral domain of polarized epithelial cells and interacts with cytosolic PDZ (PSD-95, discs large, ZO-1) domain-containing proteins. Here, we show that the polarity of s... | 18,764,819 |
Comparison of the in vitro properties of apheresis platelets during 7-day storage after interrupting agitation for one or three periods. | Many platelet (PLT) components undergo multiple periods of shipment before transfusion. We have previously conducted studies investigating maintenance of apheresis PLT in vitro quality measures during a single 24- or 30-hour interruption of agitation, but data are not available for multiple periods without agitation. A... | 18,764,829 |
The orthotopic left lung transplantation in rats: a valuable experimental model without using cuff technique. | Advances in the field of clinical lung transplantation must rely on observations made in animal models. In this study, we introduced a new procedure in the rat, orthotopic left lung transplantation without using the cuff technique, in which the donor pulmonary artery, pulmonary vein, and membranous parts of the bronchu... | 18,764,833 |
Maternal sensitivity: a concept analysis. | The aim of this paper is to report a concept analysis of maternal sensitivity. Maternal sensitivity is a broad concept encompassing a variety of interrelated affective and behavioural caregiving attributes. It is used interchangeably with the terms maternal responsiveness or maternal competency, with no consistency of ... | 18,764,848 |
Total serum bilirubin levels during cyclooxygenase inhibitor treatment for patent ductus arteriosus in preterm infants. | To determine whether ibuprofen use in VLBW infants is associated with increased serum bilirubin levels and impaired neurodevelopmental outcome at 2 years of age compared to indomethacin. We retrospectively evaluated bilirubin data and outcome parameters of 178 VLBW infants treated with COX inhibitors for a haemodynamic... | 18,764,861 |
Metagenomic and stable isotopic analyses of modern freshwater microbialites in Cuatro Ciénegas, Mexico. | Ancient biologically mediated sedimentary carbonate deposits, including stromatolites and other microbialites, provide insight into environmental conditions on early Earth. The primary limitation to interpreting these records is our lack of understanding regarding microbial processes and the preservation of geochemical... | 18,764,874 |
A culture-independent study of free-living fungi in biological soil crusts of the Colorado Plateau: their diversity and relative contribution to microbial biomass. | Molecular methodologies were used to investigate free-living fungal communities associated with biological soil crusts (BSCs), along km-scale transects on the Colorado Plateau (USA). Two cyanobacteria-dominated crust types that did not contain significant lichen cover were examined. Fungal community diversity and compo... | 18,764,875 |
Proteome analysis at the subcellular level of the cyanobacterium Spirulina platensis in response to low-temperature stress conditions. | The present study addresses the differential expression of Spirulina platensis proteins detected during cold-induced stress, analyzed at the subcellular level. In performing differential expression analysis, the results revealed upregulated proteins in every subcellular fraction, including two-component response system... | 18,764,876 |
Nitric oxide produces HLA-G nitration and induces metalloprotease-dependent shedding creating a tolerogenic milieu. | Human leucocyte antigen G (HLA-G) is a tolerogenic molecule that protects the fetus from maternal immune attack, may favour tumoral immunoescape and is up-regulated in viral and inflammatory diseases. The aim of this work was to discover if nitric oxide (NO) could affect HLA-G expression or function because NO is an im... | 18,764,882 |
Ultraviolet radiation as a limiting factor in leaf expansion and development. | Reductions in leaf growth are a commonly observed response to ultraviolet radiation, but the underlying mechanisms remain poorly defined. This study examined the response of leaves exposed to a UV environment across a range of organizational scales, including leaf expansion rate, epidermal cell size and number, biomech... | 18,764,892 |
Metabolic engineering towards the enhancement of photosynthesis. | Photosynthetic capacity is a promising target for metabolic engineering of crop plants towards higher productivity. Crop photosynthesis is limited by multiple factors dependent on the environmental conditions. This includes photosynthetic electron transport, regeneration of CO2 acceptor molecules in the reductive pento... | 18,764,897 |
Expression of an Escherichia coli antigenic fusion protein comprising the heat labile toxin B subunit and the heat stable toxin, and its assembly as a functional oligomer in transplastomic tobacco plants. | Enterotoxigenic Escherichia coli (ETEC) strains are important pathogens in developing countries. Some vaccine formulations containing the heat labile toxin B subunit (LTB) have been used in clinical trials; however, the induction of neutralizing antibodies against the heat-stable toxin (ST), a poor immunogenic peptide,... | 18,764,920 |
CTD phosphatases in the attenuation of wound-induced transcription of jasmonic acid biosynthetic genes in Arabidopsis. | Trienoic fatty acids (TAs), the major constituents in plant membrane lipids, play essential roles in stress signalling as precursors of the phytohormone jasmonic acid (JA). Arabidopsis FAD7 encodes a plastidial omega-3 fatty acid desaturase, which catalyses the production of TAs. In coordination with other JA-biosynthe... | 18,764,923 |
Non-identical contributions of two membrane-bound cpSRP components, cpFtsY and Alb3, to thylakoid biogenesis. | The insertion of light-harvesting chlorophyll proteins (LHCPs) into the thylakoid membrane of the chloroplast is cpSRP-dependent, and requires the stromal components cpSRP54 and cpSRP43, the membrane-bound SRP receptor cpFtsY and the integral membrane protein Alb3. Previous studies demonstrated that the Arabidopsis mut... | 18,764,927 |
Evidence that the Amyloid beta Precursor Protein-intracellular domain lowers the stress threshold of neurons and has a "regulated" transcriptional role. | Regulated intramembrane proteolysis of the beta-amyloid precursor protein by the gamma-secretase yields two peptides. One, amyloid-beta, is the major component of the amyloid plaques found in Alzheimer's disease patients. The other, APP IntraCellular Domain, has been involved in regulation of apoptosis, calcium flux an... | 18,764,939 |
Male-killing endosymbionts: influence of environmental conditions on persistence of host metapopulation. | Male killing endosymbionts manipulate their arthropod host reproduction by only allowing female embryos to develop into infected females and killing all male offspring. Because of the reproductive manipulation, we expect them to have an effect on the evolution of host dispersal rates. In addition, male killing endosymb... | 18,764,948 |
Simultaneous circulation of genotypes I and III of dengue virus 3 in Colombia. | Dengue is a major health problem in tropical and subtropical regions. In Colombia, dengue viruses (DENV) cause about 50,000 cases annually, 10% of which involve Dengue Haemorrhagic Fever/Dengue Shock Syndrome. The picture is similar in other surrounding countries in the Americas, with recent outbreaks of severe disease... | 18,764,951 |
Traumatic brain injury in young children: postacute effects on cognitive and school readiness skills. | Previous studies have documented weaknesses in cognitive ability and early academic readiness in young children with traumatic brain injury (TBI). However, few of these studies have rigorously controlled for demographic characteristics, examined the effects of TBI severity on a wide range of skills, or explored moderat... | 18,764,969 |
Cognitive and adaptive deficits in young children with Duchenne muscular dystrophy (DMD). | The goal of the current investigation was to examine adaptive behavior and cognitive skills in young children with Duchenne muscular dystrophy (DMD), a genetic disorder that causes progressive muscular weakness and concomitant cognitive deficits. Previous studies have documented specific language deficits in older chil... | 18,764,980 |
Directed forgetting in depression. | Subjects with depression exhibit deficits in prefrontal function. We posited that as a result, in a supraspan memory test, they would be impaired in their ability to inhibit recall of irrelevant words, and because of consequent overload of working and episodic memory capacity, would be impaired in their ability to reca... | 18,764,986 |
[Risk behaviors for sexually transmitted diseases among truck drivers in Brazil]. | To evaluate the frequency of sexually transmitted diseases (STD) and associated risk factors based on self-reporting by long-haul truck drivers in Brazil. From October 2005-October 2006, 641 long-haul truck drivers that travel federal highway BR-153, traversing the country from south to north, were interviewed. A struc... | 18,764,991 |
Expression analysis of TFIID in single human oocytes: new potential molecular markers of oocyte quality. | Molecular characterization of human female gametes should make it easier to understand the basis of certain infertility disorders. Biologically significant mRNAs have been analysed in single oocytes to search for molecular biomarkers of oocyte quality. Initial analysis was focused on mRNA for proteins involved in cell ... | 18,765,004 |
Workload and resource implications of upper gastrointestinal cancer surgical centralisation in South East Wales. | The aim of this study was to determine whether one specialist unit could manage all patients diagnosed with oesophagogastric cancer in Gwent and Cardiff and Vale NHS Trusts over a 6-month period with regard to workload, resource and training opportunities. All patients diagnosed with oesophagogastric (OG) cancer in Gwe... | 18,765,024 |
Laparoscopically assisted vaginal hysterectomy versus vaginal hysterectomy for enlarged uterus. | To compare the surgical and immediate postoperative outcomes for vaginal hysterectomy (VH) with those for laparoscopically assisted vaginal hysterectomy (LAVH) in patients with enlarged myomatous uterus. Eighty women requiring hysterectomy for an enlarged myomatous uterus were randomly allocated into 2 treatment arms: ... | 18,765,046 |
Robot-assisted laparoscopic ileal ureter. | A patient with a solitary kidney, cysteine stones, and recurrent ureteral strictures underwent robot-assisted laparoscopic ureterectomy with ileal ureter formation. Using a transperitoneal, 4-port robotic approach, we removed the strictured ureter and created an ileal ureter. The ileal-pyelo and ileal-vesical anastomos... | 18,765,059 |
Laparoscopic management of small bowel intussusception in a 16-year-old with Peutz-Jeghers syndrome. | Peutz-Jeghers is a rare autosomal dominant disorder characterized by hamartomatous polyps and discoloration of mucosal membranes. The polyps can occur anywhere in the gastrointestinal tract and can grow large enough to cause bowel obstructions. A 16-year-old male presented to the emergency department with signs and sym... | 18,765,065 |
Laparoscopic resection of a virilizing adrenocortical tumor. | Virilizing adrenocortical tumors are rare. Laparoscopic unilateral adrenalectomy with serum androgen surveillance may provide curative treatment for benign, functional adenomas. Herein, we describe a case of laparoscopic resection of a testosterone-producing adrenal tumor in a sixteen-year-old female. | 18,765,068 |
Insights into natriuretic peptides in heart failure: an update. | Natriuretic peptides (NPs) secreted by the heart in response to volume overload are pleiotropic molecules with vasodilating, diuretic, natriuretic, antiproliferative, and antifibrotic actions. Functioning of the NP system is altered in congestive heart failure (CHF), suggesting that support of the NP system might be be... | 18,765,080 |
Prevention of atrial fibrillation in hypertension. | Hypertensive patients have an increased risk of developing atrial fibrillation (AF), which increases cardiovascular morbidity and mortality in this population. Primary prevention is a new strategy in treating AF; previously, it was more common to focus on preventing adverse outcomes and controlling the arrhythmia's rat... | 18,765,086 |
Gram-negative endocarditis. | Aerobic gram-negative bacilli are rare causes of endocarditis. The epidemiology and risk factors for developing gram-negative endocarditis are evolving. New pathogens, some of which are multidrug resistant, are emerging. The role of nosocomial infections, particularly central venous catheter infections, is increasing. ... | 18,765,099 |
16S-Ribosomal DNA to diagnose culture-negative endocarditis. | Culture-negative endocarditis (CNE) accounts for 2.5% to 48% of all cases of infectious endocarditis (IE). Prior or concurrent antibiotic treatment at the time blood cultures are taken accounts for 45% to 60% cases of CNE; the remainder are caused by slow-growing and fastidious organisms. Although limited in sensitivit... | 18,765,101 |
Acute disseminated encephalomyelitis. | Acute disseminated encephalomyelitis (ADEM) is a demyelinating syndrome of the central nervous system. It is considered to be an autoimmune response to an antecedent antigenic stimulus, most frequently a prior infectious illness (postinfectious encephalitis) or immunization (postvaccination encephalitis) occurring in t... | 18,765,104 |
Growth factors in benign prostatic hyperplasia: basic science implications. | Benign prostatic hyperplasia (BPH) is the most common proliferative disease of the prostate of men in the United States. The histopathology of BPH strongly implicates local paracrine and autocrine growth factors and inflammatory cytokines in its pathogenesis. A complex milieu of growth-regulatory proteins includes memb... | 18,765,125 |
Combination 5-alpha-reductase inhibitors and alpha-blockers for treatment of lower urinary tract symptoms secondary to benign prostatic hyperplasia. | Open or transurethral resection of the prostate was once the only option for men afflicted with symptomatic benign prostatic hyperplasia (BPH). In the past 10 to 15 years, however, medical management has become a common step in the treatment of BPH, often postponing or eliminating the need for surgical intervention. Th... | 18,765,128 |
Central mechanisms in the maintenance of chronic widespread noninflammatory muscle pain. | Chronic widespread pain (CWP) conditions such as fibromyalgia and myofascial syndromes are characterized by generalized pain, tenderness, morning stiffness, disturbed sleep, and pronounced fatigue. However, CWP pathophysiology is still unclear. A number of hypotheses have been proposed as the underlying pathophysiology... | 18,765,138 |
Prevalence and geographic distribution of childhood obesity in China in 2005. | China now joins the world epidemic of childhood obesity. Because of the large disparity of environmental conditions across various sub-populations, accurate prevalence of obesity/overweight cannot be estimated by population-based approaches. Using a resident-based targeted approach, we determined the geographical distr... | 18,765,165 |
Practical guide for three-dimensional transthoracic echocardiography using a fully sampled matrix array transducer. | Real-time three-dimensional (3D) echocardiography is a major innovation in the history of cardiovascular ultrasound. Advances in computer and transducer technologies, especially the fully-sampled matrix array transducer, have permitted real-time 3D image acquisition and display. Several vendors provide 3D imaging but u... | 18,765,173 |
Low-flow perfusion of guinea pig isolated hearts with 26 degrees C air-saturated Lifor solution for 20 hours preserves function and metabolism. | Donor human hearts cannot be preserved for >5 hours between explantation and recipient implantation. A better approach is needed to preserve transplantable hearts for longer periods, ideally at ambient conditions for transport. We tested whether Lifor solution could satisfactorily preserve guinea pig isolated hearts... | 18,765,194 |
Non-heart-beating lung donation: how big is the pool? | Lungs from non-heart-beating (NHB) donors are seldom used in The Netherlands despite the good quality of these organs. Based on a retrospective analysis of 162 NHB donor procedures we found that only 5% of the lungs were actually utilized, but that 30% of the lungs were suitable for transplantation. Not recognizing the... | 18,765,199 |
Genomics: risk and outcomes in cardiac surgery. | Coronary artery bypass graft surgery is associated with several frequent postoperative adverse events. Outcome prediction is valued by patients and practitioners, because it provides some measure of balancing risks and benefits and provides expensive or higher-risk therapies to individuals at highest risk. Surgeons and... | 18,765,214 |
Hybrid coronary artery bypass grafting. | Owing to the high prevalence of atherosclerotic coronary artery disease, treatment has proceeded along three separate paths: medical, surgical, and percutaneous intervention. Medical treatment is now routinely combined with both surgical treatment and percutaneous methods; however, the surgical and percutaneous routes ... | 18,765,217 |
A transient breach in the epithelial barrier leads to regulatory T-cell generation and resistance to experimental colitis. | Previous studies have indicated that a defective epithelial barrier leads to inflammation of the underlying lamina propria. Nevertheless, it is likely that physiologic breaks in the barrier must occur for homeostatic regulatory T cells to develop. We determined the effect of agents that disrupt epithelial tight junctio... | 18,765,239 |
Circulating prolactin, MPOA prolactin receptor expression and maternal aggression in lactating rats. | Maternal aggression is most intense in lactating rats from the 3rd to the 12th day postpartum. The purpose of this study was to determine if plasma prolactin (PRL) and prolactin receptor (PRL-R(L)) mRNA expression in the medial preoptic area (MPOA) of lactating rats are altered in association with maternal aggression. ... | 18,765,257 |
One-step isolation of plasma membrane proteins using magnetic beads with immobilized concanavalin A. | We have developed a simple method for isolating and purifying plasma membrane proteins from various cell types. This one-step affinity-chromatography method uses the property of the lectin concanavalin A (ConA) and the technique of magnetic bead separation to obtain highly purified plasma membrane proteins from crude m... | 18,765,283 |
Endoplasmic reticulum stress underlying the pro-apoptotic effect of epigallocatechin gallate in mouse hepatoma cells. | It has been recently reported that tea flavanols, including epigallocatechin gallate (EGCG), efficiently inhibit glucosidase II in liver microsomes. Since glucosidase II plays a central role in glycoprotein processing and quality control in the endoplasmic reticulum we investigated the possible contribution of endoplas... | 18,765,294 |
Gimbals in the insect leg. | We studied the common kinematic features of the coxa and trochanter in cursorial and raptorial legs, which are the short size of the podomers, predominantly monoaxial joints, and the approximate orthogonality of adjacent joint axes. The chain coxa-trochanter with its short elements and serial orthogonality of joint axe... | 18,765,299 |
Bortezomib and the increased incidence of herpes zoster in patients with multiple myeloma. | Bortezomib has significantly advanced the treatment of patients with multiple myeloma (MM). However, considering that most patients with MM are elderly, bortezomib-related morbidity should be thoroughly studied to ensure the safe use of this drug. Herpes zoster has been reported as a possible adverse event associated w... | 18,765,311 |
Genome size and wing parameters in passerine birds. | Despite their status as the most speciose group of terrestrial vertebrates, birds exhibit the smallest and least variable genome sizes among tetrapods. It has been suggested that this is because powered flight imposes metabolic constraints on cell size, and thus on genome size. This notion has been supported by analyse... | 18,765,340 |
New Caledonia: a very old Darwinian island? | New Caledonia has generally been considered a continental island, the biota of which largely dates back to Gondwanan times owing to its geological origin and the presence of phylogenetic relicts. This view is contradicted by geological evidence indicating long Palaeocene and Eocene submersions and by recent biogeograph... | 18,765,357 |
Cryptic diversity, molecular phylogeny and biogeography of the rock- and leaf litter-dwelling land snails of Belau (Republic of Palau, Oceania). | The endemic diplommatinid land snails (Caenogastropoda: Mollusca) of Belau (Republic of Palau, Micronesia) are an exceptionally diverse group of largely undescribed species distributed among rock and leaf litter habitats on most of Belau's 586 islands. Diplommatinid shell morphology (e.g. shell sculpture) reflects habi... | 18,765,361 |
Characterization and expression of a Pinus radiata putative ortholog to the Arabidopsis SHORT-ROOT gene. | We characterized a Pinus radiata D. Don putative ortholog to the Arabidopsis thaliana (L.) Heynh. SHORT--ROOT gene (AtSHR) and analyzed its expression in different organs during vegetative development and in response to exogenous auxin during adventitious rooting. The predicted protein sequence contained domains charac... | 18,765,368 |
Water stress responses of two Mediterranean tree species influenced by native soil microorganisms and inoculation with a plant growth promoting rhizobacterium. | Soil microorganisms, such as plant growth-promoting rhizobacteria (PGPR), play crucial roles in plant growth, but their influence on plant water relations remains poorly explored. We studied the effects of native soil microorganisms and inoculation with the PGPR strain Aur6 of Pseudomonas fluorescens on water stress re... | 18,765,374 |
Hot flashes and subclinical cardiovascular disease: findings from the Study of Women's Health Across the Nation Heart Study. | Although evidence suggests adverse vascular changes among women with hot flashes, it is unknown whether hot flashes are associated with subclinical cardiovascular disease. The aim of this study was to examine relations between menopausal hot flashes and indices of subclinical cardiovascular disease. We hypothesized tha... | 18,765,392 |
Combined statin and niacin therapy remodels the high-density lipoprotein proteome. | Boosting low high-density lipoprotein (HDL) levels is a current strategy for preventing clinical events that result from cardiovascular disease. We previously showed that HDL(3) of subjects with coronary artery disease is enriched in apolipoprotein E and that the lipoprotein carries a distinct protein cargo. This obser... | 18,765,395 |
Perinatal outcome of fetal atrioventricular block: one-hundred-sixteen cases from a single institution. | Fetal atrioventricular (AV) block is an uncommon lesion with significant mortality. Because of the rarity of this disorder, the natural course, extensive evaluation of untreated fetuses, and late follow-up remain unclear. Of the 116 consecutive cases of fetal AV block studied from 1988 to 2006, only 1 was terminated, a... | 18,765,396 |
Evaluating the impact of a national pilot screening programme for type 2 diabetes in deprived areas of England. | A pilot programme designed to systematically screen for type 2 diabetes was introduced in 24 general practices in England selected for their high levels of socio-economic deprivation and multi-ethnic populations. To evaluate the impact of screening on the prevalence of type 2 diabetes. A prospective audit of screening ... | 18,765,406 |
A meta-analysis on XRCC1 R399Q and R194W polymorphisms, smoking and bladder cancer risk. | To elucidate the role of X-ray repair cross-complementing group 1 (XRCC1) R399Q and R194W genotypes in bladder cancer risk, all available studies were considered in the present meta-analysis, with 4152 patients and 5372 controls for R399Q and 3215 patients and 4313 controls for R194W. Studies were identified in PubMed ... | 18,765,423 |
From the two-dimensional Th1 and Th2 phenotypes to high-dimensional models for gene regulation. | The T(h)1/T(h)2 paradigm has been used for decades to characterize phenotypically different immune responses. Recent discoveries, e.g. T(h)17 cells are adding more dimensions to the helper T cell framework, and the T(h)1/T(h)2 paradigm is currently being extended to include these new phenotypes. Previous mathematical m... | 18,765,426 |
Cellular characterisation of magnetic resonance imaging bone oedema in rheumatoid arthritis; implications for pathogenesis of erosive disease. | Magnetic resonance imaging (MRI) bone oedema is an important predictor of bone erosion in rheumatoid arthritis (RA). This study aimed to determine the cellular components of MRI bone oedema, and clarify the relationship between bone erosion and MRI bone oedema. Twenty-eight bones from 11 patients with RA undergoing ort... | 18,765,428 |
Patient perspective of hand osteoarthritis in relation to concepts covered by instruments measuring functioning: a qualitative European multicentre study. | To explore whether the concepts important to patients with hand osteoarthritis (OA) are covered by the most commonly used instruments measuring functioning. A qualitative multicentre study using a focus group technique was performed in five European countries: Austria, The Netherlands, Norway, Sweden and the United Kin... | 18,765,429 |
DNA replication timing is deterministic at the level of chromosomal domains but stochastic at the level of replicons in Xenopus egg extracts. | Replication origins in Xenopus egg extracts are located at apparently random sequences but are activated in clusters that fire at different times during S phase under the control of ATR/ATM kinases. We investigated whether chromosomal domains and single sequences replicate at distinct times during S phase in egg extrac... | 18,765,475 |
Non-parametric estimation of state occupation, entry and exit times with multistate current status data. | As a type of multivariate survival data, multistate models have a wide range of applications, notably in cancer and infectious disease progression studies. In this article, we revisit the problem of estimation of state occupation, entry and exit times in a multistate model where various estimators have been proposed in... | 18,765,503 |
Overexpression of the zinc uptake transporter hZIP1 inhibits nuclear factor-kappaB and reduces the malignant potential of prostate cancer cells in vitro and in vivo. | Intracellular zinc levels and expression of the zinc uptake transporter, hZIP1, are markedly down-regulated in prostate adenocarcinomatous tissue compared with normal prostate tissue. Our previous studies have shown that zinc inhibits nuclear factor-kappaB (NF-kappaB) activity and reduces the malignant potential of pro... | 18,765,529 |
Inhibition of the p53 E3 ligase HDM-2 induces apoptosis and DNA damage--independent p53 phosphorylation in mantle cell lymphoma. | The ubiquitin-proteasome pathway has been validated as a target in non-Hodgkin's lymphoma through demonstration of the activity of the proteasome inhibitor bortezomib. Another potentially attractive target is the human homologue of the murine double minute-2 protein, HDM-2, which serves as the major p53 E3 ubiquitin li... | 18,765,533 |
Genetic clustering of clear cell renal cell carcinoma based on array-comparative genomic hybridization: its association with DNA methylation alteration and patient outcome. | The aim of this study was to clarify genetic and epigenetic alterations occurring during renal carcinogenesis. Copy number alterations were examined by array-based comparative genomic hybridization analysis using an array harboring 4,361 bacterial artificial chromosome clones, and DNA methylation alterations on CpG isl... | 18,765,545 |
Magnetic resonance imaging-measured blood flow change after antiangiogenic therapy with PTK787/ZK 222584 correlates with clinical outcome in metastatic renal cell carcinoma. | To measure changes in tumor blood flow following treatment with PTK787/ZK 222584, a pan-vascular endothelial growth factor receptor tyrosine kinase inhibitor, and their association with clinical response in patients with metastatic renal cell carcinoma. In 10 patients with metastatic renal cell carcinoma treated with P... | 18,765,547 |
A phase I study of bexarotene, a retinoic X receptor agonist, in non-M3 acute myeloid leukemia. | Bexarotene is a retinoic X receptor agonist that has been shown in vitro to inhibit growth and induce differentiation of myeloid leukemic cell lines. We therefore conducted a phase I dose escalation study to assess the maximum tolerated dose, toxicities, and activity of bexarotene in patients with non-M3 acute myeloid ... | 18,765,556 |
Recruitment of mismatch repair proteins to the site of DNA damage in human cells. | Mismatch repair (MMR) proteins contribute to genome stability by excising DNA mismatches introduced by DNA polymerase. Although MMR proteins are also known to influence cellular responses to DNA damage, how MMR proteins respond to DNA damage within the cell remains unknown. Here, we show that MMR proteins are recruited... | 18,765,568 |
Effects of method of presynchronization and source of selenium on uterine health and reproduction in dairy cows. | The objectives of this study were to evaluate the effects of method of presynchronization and source of supplemental Se on uterine health and reproductive performance of lactating dairy cows. Holstein cows (n = 512) were assigned randomly to 2 methods of presynchronization, Presynch (2 PGF(2a) given 14 d apart) or CIDR... | 18,765,591 |
Developmental histology, segmental expression, and nutritional regulation of somatotropic axis genes in small intestine of preweaned dairy heifers. | Components of the somatotropic axis and nutrition regulate intestinal development and maturation of enterocytes. We measured gene expression in the mucosal layer of small intestine of preweaned dairy heifers to test the hypothesis that feeding increased amounts of protein and fat alters expression of somatotropic axis ... | 18,765,593 |
How does live yeast differ from sodium bicarbonate to stabilize ruminal pH in high-yielding dairy cows? | The objectives of this study were to evaluate the capacity of 2 dietary feed additives, sodium bicarbonate and live yeast Saccharomyces cerevisiae (strain Sc 47), in optimizing ruminal pH in dairy cows and to determine their modes of action. Three early lactating Holstein cows, fitted with ruminal cannulas, were alloca... | 18,765,611 |
Quantitative trait loci underlying udder morphology traits in dairy sheep. | A genome scan was conducted on the basis of the daughter design to detect quantitative trait loci (QTL) influencing udder morphology traits in Spanish Churra dairy sheep. A total of 739 ewes belonging to 11 half-sib families were genotyped for 182 microsatellite markers covering 3,248.2 cM (Kosambi) of the ovine autoso... | 18,765,625 |
Short communication: new alleles of the bovine kappa-casein gene revealed by resequencing and haplotype inference analysis. | We tested the hypothesis that extensive undiscovered genetic diversity exists in important functional genes from domestic and wild cattle species (Bos spp.). We resequenced 483 bp of a key exon (exon IV) from the kappa (kappa)-casein gene (CSN3) for a panel of samples of domestic cattle from 8 countries and a close rel... | 18,765,626 |
Short communication: casein haplotype variability in sicilian dairy goat breeds. | In the Mediterranean region, goat milk production is an important economic activity. In the present study, 4 casein genes were genotyped in 5 Sicilian goat breeds to 1) identify casein haplotypes present in the Argentata dell'Etna, Girgentana, Messinese, Derivata di Siria, and Maltese goat breeds; and 2) describe the s... | 18,765,627 |
Heritability of the severity of diabetic retinopathy: the FIND-Eye study. | Diabetic retinopathy (DR) and diabetic nephropathy (DN) are serious microvascular complications of diabetes mellitus. Correlations between severity of DR and DN and computed heritability estimates for DR were determined in a large, multiethnic sample of diabetic families. The hypothesis was that (1) the severity of DR ... | 18,765,632 |
Spinal anaesthesia for elective surgery: a comparison of hyperbaric solutions of racemic bupivacaine, levobupivacaine, and ropivacaine. | The aim of this study was to compare the clinical effects of 'hyperbaric' bupivacaine for spinal anaesthesia with those of similar preparations of levobupivacaine and ropivacaine. Sixty ASA grade I-II patients undergoing elective surgery under spinal anaesthesia were randomized to receive 3 ml of bupivacaine, levobupiv... | 18,765,643 |
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