title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
|---|---|---|
Antiepileptic drug use and rates of hip bone loss in older men: a prospective study. | To test the hypotheses that older community dwelling men taking non-enzyme-inducing antiepileptic drugs (NEIAEDs) and those taking enzyme-inducing antiepileptic drugs (EIAEDs) have increased rates of hip bone loss. We ascertained antiepileptic drug (AED) use (interviewer-administered questionnaire with verification of ... | 18,765,648 |
Dual activation of phospholipase C-epsilon by Rho and Ras GTPases. | Phospholipase C-epsilon (PLC-epsilon) is a highly elaborated PLC required for a diverse set of signaling pathways. Here we use a combination of cellular assays and studies with purified proteins to show that activated RhoA and Ras isoforms directly engage distinct regions of PLC-epsilon to stimulate its phospholipase a... | 18,765,661 |
The sushi domains of secreted GABA(B1) isoforms selectively impair GABA(B) heteroreceptor function. | GABA(B) receptors are the G-protein-coupled receptors for gamma-aminobutyric acid (GABA), the main inhibitory neurotransmitter in the brain. GABA(B) receptors are promising drug targets for a wide spectrum of psychiatric and neurological disorders. Receptor subtypes exhibit no pharmacological differences and are based ... | 18,765,663 |
Novel variants of Oct-3/4 gene expressed in mouse somatic cells. | It has been suggested that Oct-3/4 may regulate self-renewal in somatic stem cells, as it does in embryonic stem cells. However, recent reports raise the possibility that detection of human Oct-3/4 expression by RT-PCR is prone to artifacts generated by pseudogene transcripts and argue against a role for Oct-3/4 in som... | 18,765,667 |
Tibial fixation of bone-patellar tendon-bone grafts in anterior cruciate ligament reconstruction: a cadaveric study of bovine bone screw and biodegradable interference screw. | The use of interference screw fixation for bone-patellar tendon-bone grafts in anterior cruciate ligament fixation is well established. No previous study has compared bovine bone screws and biodegradable interference screws or demonstrated their efficacy for requirements associated with early rehabilitation. There is n... | 18,765,676 |
Use of labeled oral minimal model to measure hepatic insulin sensitivity. | The ability to accurately quantify indexes of the individual role of glucose (GE(L)) and insulin (S(I)(L)) in the suppression of endogenous glucose production (EGP) would improve the understanding of liver metabolism. Measuring these indexes during an IVGTT by minimal modeling of tracer labeled and unlabeled glucose da... | 18,765,681 |
Vaccination of mice with a Yop translocon complex elicits antibodies that are protective against infection with F1- Yersinia pestis. | Yersinia pestis, the bacterial agent of plague, secretes several proteins important for pathogenesis or host protection. The F1 protein forms a capsule on the bacterial cell surface and is a well-characterized protective antigen but is not essential for virulence. A type III secretion system that is essential for virul... | 18,765,742 |
Community-based inquiry improves critical thinking in general education biology. | National stakeholders are becoming increasingly concerned about the inability of college graduates to think critically. Research shows that, while both faculty and students deem critical thinking essential, only a small fraction of graduates can demonstrate the thinking skills necessary for academic and professional su... | 18,765,755 |
Evaluation of intra-annual variation in U.S. Geological Survey National Water Quality Assessment ground water quality data. | Assessment of ground-water quality trends under the U.S. Geological Survey National Water-Quality Assessment Program (NAWQA) included the analysis of samples collected on a quarterly basis for 1 yr between 2001 and 2005. The purpose of this quarterly sampling was to test the hypothesis that variations in the concentrat... | 18,765,766 |
Short-term sustainability of drainage water reuse: spatio-temporal impacts on soil chemical properties. | Greater urban demand for finite water resources, increased frequency of drought resulting from erratic weather, and increased pressure to reduce drainage water volumes have intensified the need to reuse drainage water. A study was initiated in 1999 on a 32.4-ha saline-sodic field (Lethent clay loam series; fine, montmo... | 18,765,781 |
The RNA-binding protein XSeb4R: a positive regulator of VegT mRNA stability and translation that is required for germ layer formation in Xenopus. | VegT represents a localized maternal determinant essentially required for endoderm formation in Xenopus. Here, we report on the identification of the RNA-binding protein XSeb4R as a positive regulator of VegT. XSeb4R interacts directly with the 3'-untranslated region of VegT mRNA, stabilizes it, and stimulates translat... | 18,765,788 |
Rice jmjC domain-containing gene JMJ706 encodes H3K9 demethylase required for floral organ development. | Histone lysine methylation is an important epigenetic modification with both activating and repressive roles in gene expression. Jumonji C (jmjC) domain-containing proteins have been shown to reverse histone methylation in nonplant model systems. Here, we show that plant Jumonji C proteins have both conserved and speci... | 18,765,808 |
Voluntary running rescues adult hippocampal neurogenesis after irradiation of the young mouse brain. | Cranial radiation therapy is commonly used in the treatment of childhood cancers. It is associated with cognitive impairments tentatively linked to the hippocampus, a neurogenic region of the brain important in memory function and learning. Hippocampal neurogenesis is positively regulated by voluntary exercise, which i... | 18,765,809 |
MEDME: an experimental and analytical methodology for the estimation of DNA methylation levels based on microarray derived MeDIP-enrichment. | DNA methylation is an important component of epigenetic modifications that influences the transcriptional machinery and is aberrant in many human diseases. Several methods have been developed to map DNA methylation for either limited regions or genome-wide. In particular, antibodies specific for methylated CpG have bee... | 18,765,822 |
Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides. | We have studied the potential contribution of ABCG2 (breast cancer resistance protein) to resistance to nucleoside analogues. In cells transfected with DNA constructs resulting in overexpression of human or mouse ABCG2, we found resistance against cladribine, clofarabine, fludarabine, 6-mercaptopurine, and 6-mercaptopu... | 18,765,824 |
Genetic variants associated with carboplatin-induced cytotoxicity in cell lines derived from Africans. | To gain a better understanding of the genetic variants associated with carboplatin-induced cytotoxicity in individuals of African descent, we present a step-wise approach integrating genotypes, gene expression, and sensitivity of HapMap cell lines to carboplatin. Cell lines derived from 30 trios of African descent (YRI... | 18,765,826 |
Alternative wnt signaling is initiated by distinct receptors. | An unanswered question in the field of signal transduction research is how different signaling pathways are activated with strict specificity in a temporally and spatially controlled manner. Because extracellular ligands and membrane receptors constitute the first signaling modalities for most pathways, selectivity in ... | 18,765,832 |
Comparison of production traits between pigs with and without the Escherichia coli F4 receptors in a White Duroc x Erhualian intercross F2 population. | To evaluate the influence of enterotoxigenic Escherichia coli (ETEC) F4 receptors on production traits in pigs, ETEC F4ab, F4ac, and F4ad adhesion phenotypes and 27 traits related to growth, carcass, meat quality, and length of the small intestine in a White Duroc x Erhualian intercross population were measured. Perfor... | 18,765,849 |
Space requirements of weaned pigs during a sixty-minute transport in summer. | Currently, there are no trucking quality assurance recommendations for space allowance of weaned pigs during transport in the United States. The objective of this research was to establish a first estimate of the space requirements of weaned pigs during transport in summer based on measures of animal well-being. A comm... | 18,765,850 |
Effect of Scutellaria flavonoids on KCN-induced damages in rat pheochromocytoma PC12 cells. | Cerebral hypoxia is known to be involved in many neurodegenerative diseases such as Alzheimer's and cerebrovascular dementia. The present study was designed to investigate the effects of flavonoids from aerial part of Scutellaria baicalensis Georgi (SSF) on potassium cyanide (KCN) -induced hypoxic cytotoxicity in rat p... | 18,765,882 |
A method for 3D electron density imaging using single scattered x-rays with application to mammographic screening. | Screening mammography is the current standard in detecting breast cancer. However, its fundamental disadvantage is that it projects a 3D object into a 2D image. Small lesions are difficult to detect when superimposed over layers of normal, heterogeneous tissue. In this work, we examine the potential of single scattered... | 18,765,886 |
A preliminary study for non-invasive quantification of manganese in human hand bones. | Manganese (Mn) is a nutrient essential for regulating neurological and skeletal functions in the human body, but it is also toxic when humans are excessively exposed to Mn. Blood (or serum/plasma) and other body fluids reflect only the most recent exposure and rapidly return to within normal ranges, even when there has... | 18,765,892 |
The three-dimensional cultivation of the carcinoma cell line HepG2 in a perfused chip system leads to a more differentiated phenotype of the cells compared to monolayer culture. | We describe a polymer chip with a grid-like architecture that it is intended for the three-dimensional cultivation of cells with an active nutrient and gas supply. The chip is typically made from polymethyl methacrylate or polycarbonate but can also be manufactured from biodegradable polymers, such as poly(lactic-co-gl... | 18,765,895 |
Nano-beta-tricalcium phosphates synthesis and biodegradation: 1. Effect of microwave and SO(4)(2-) ions on beta-TCP synthesis and its characterization. | Nano-sized calcium deficient hydroxyapatite (CDHA) powders with an average particle size less than 100 nm were prepared by a co-precipitation method at low temperature. The initial Ca/P molar ratio was chosen to be less than the stoichiometric ratio of beta-TCP (1.5). Additionally, lowering the temperature and pH value... | 18,765,896 |
Purification, crystallization and preliminary X-ray analysis of human mannose-binding lectin-associated serine protease-1 (MASP-1) catalytic region. | MASP-1, a multidomain serine protease, is a component of the lectin pathway of complement. Its precise function is unknown, although it seems to enhance the complement-activating capacity of MASP-2, a related enzyme. MASP-1 has also been implicated as playing a role in blood coagulation. It is mostly found associated w... | 18,765,903 |
Preliminary X-ray diffraction analysis of YqjH from Escherichia coli: a putative cytoplasmic ferri-siderophore reductase. | YqjH is a cytoplasmic FAD-containing protein from Escherichia coli; based on homology to ViuB of Vibrio cholerae, it potentially acts as a ferri-siderophore reductase. This work describes its overexpression, purification, crystallization and structure solution at 3.0 A resolution. YqjH shares high sequence similarity w... | 18,765,906 |
Crystallization and preliminary X-ray diffraction analysis of the peptidylprolyl isomerase Par27 of Bordetella pertussis. | Proteins with both peptidylprolyl isomerase (PPIase) and chaperone activities play a crucial role in protein folding in the periplasm of Gram-negative bacteria. Few such proteins have been structurally characterized and to date only the crystal structure of SurA from Escherichia coli has been reported. Par27, the proto... | 18,765,910 |
Crystallization and preliminary X-ray diffraction studies of the calcium-binding protein CalD from Streptomyces coelicolor. | Calcium ions play an important regulatory role in eukaryotes. However, the regulatory roles of Ca(2+) in prokaryotes are poorly understood. CalD, an 18 kDa calcium-binding protein from the model actinomycete Streptomyces coelicolor A3(2), was purified and crystallized for structure determination by X-ray crystallograph... | 18,765,912 |
1,25-Dihydroxy vitamin D3 is an autocrine regulator of extracellular matrix turnover and growth factor release via ERp60-activated matrix vesicle matrix metalloproteinases. | As growth plate chondrocytes mature and hypertrophy, they reorganize their proteoglycan-rich type II collagen extracellular matrix (ECM), involving 1,25(OH)(2)D(3)-dependent regulation of matrix metalloproteinases (MMPs). Stromelysin-1 (MMP-3) and 72-kD gelatinase (MMP-2) are found in extracellular matrix vesicles (MVs... | 18,765,931 |
Magnetocardiography-guided management of an unusual case of isoimmune complete atrioventricular block complicated by ventricular tachycardia. | A fetus who was diagnosed at 25 weeks of gestation with isoimmune AV block presented at 34 weeks with a precipitous fall in ventricular rate and periods of tachycardia. Magnetocardiography revealed the tachycardia to be ventricular. After delivery, nonsustained ventricular tachycardia continued. The baby then successfu... | 18,765,944 |
Perceived stigmatization of children with speech-language impairment and their parents. | Developmental disorders in childhood are generally assumed to have stigmatizing effects. The goal of the present study was to assess whether parents of children with speech-language impairment perceive stigmatization of their child or themselves and which variables influence the degree of negative labeling. The study w... | 18,765,946 |
Transforming growth factor-beta signaling in thoracic aortic aneurysm development: a paradox in pathogenesis. | Thoracic aortic aneurysms (TAAs) are potentially devastating, and due to their asymptomatic behavior, pose a serious health risk characterized by the lack of medical treatment options and high rates of surgical morbidity and mortality. Independent of the inciting stimuli (biochemical/mechanical), TAA development procee... | 18,765,947 |
The phenomenology of the psychotic break and Huxley's trip: substance use and the onset of psychosis. | While considerable research attention has been devoted to the causal relationship between substance use and psychosis, the phenomenology of the association between the two has largely been ignored. This is a significant shortcoming, because it blinds researchers to the possibility that there may be elements of the subj... | 18,765,960 |
DSM-IV personality disorders and their axis I correlates in the South African population. | The prevalence of personality disorders (PD) in the South African population is largely unknown. Thus, we undertook to estimate prevalence, demographic correlates, co-morbidity and treatment rates of DSM-IV PD among South Africans. A three-stage probability sample design was used. Of the 4,433 interviews obtained, base... | 18,765,961 |
Improved effectiveness of nanoparticle albumin-bound (nab) paclitaxel versus polysorbate-based docetaxel in multiple xenografts as a function of HER2 and SPARC status. | Nanoparticle albumin-bound (nab)-paclitaxel (Abraxane) is an albumin-bound 130-nm particle form of paclitaxel that demonstrated higher efficacy and was well tolerated compared with solvent-based paclitaxel (Taxol) and docetaxel (Taxotere) in clinical trials for metastatic breast cancer. Nab-paclitaxel enhances tumor ta... | 18,766,004 |
Auditory frequency-following responses in rat ipsilateral inferior colliculus. | Auditory frequency-following responses (FFRs) are sustained potentials based on phase-locked neural activity preserving low-frequency information. Some neurons in rat inferior colliculus are excited by stimuli at either ear. This study shows that FFRs in inferior colliculus can be elicited by presenting pure tone burst... | 18,766,015 |
FMRI/ERP of musical syntax: comparison of melodies and unstructured note sequences. | To date, the neural correlates of musical syntax processing have been investigated mainly by means of paradigms in which isolated chords are made incongruent with the harmonic context. Here, we present results obtained contrasting unfamiliar one-part piano melodies with unstructured note sequences, comparable in pitch ... | 18,766,016 |
Breast reduction: does the tumescent technique affect reimbursement? | Breast reduction is a very common procedure within the field of plastic surgery, with many techniques. These techniques include differences in the location of the pedicles and of the scars. Another variation on the technique for breast reduction relates to preoperative infiltration of an epinephrine solution to reduce ... | 18,766,030 |
Value of blood adipose tissue hormones concentration--adiponectin, resistin and leptin in the prediction of major adverse cardiac events (MACE) in 1-year follow-up after primary percutaneous coronary intervention in ST-segment elevation acute myocardial infarction. | The objective of the study was to assess the impact of adipokines on the future major adverse cardiac events (MACE) in patients with acute myocardial infarction. Subjects were 77 men with first, ST-segment elevation acute myocardial infarction undergoing primary percutaneous coronary intervention in whom data were avai... | 18,766,137 |
Adjunctive aripiprazole decreased metabolic side effects of clozapine treatment. | Clozapine is an atypical antipsychotic indicated for the treatment of refractory schizophrenia. Clozapine treatment is associated with the metabolic side effects. Weight gain, hyperlipidemia and hyperglycemia are the risk factors for onset of diabetes and cardiovascular disorders. We report a case vignette of a patient... | 18,766,167 |
Additional metabolic effects of adding GH receptor antagonist to long-acting somatostatin analog in patients with active acromegaly. | Somatostatin analogs, dopamine agonists and GH-receptor antagonist--pegvisomant are used in medical therapy of acromegaly. Since pegvisomant has not antitumor effect, the combination of pegvisomant and somatostatin analog could be an attractive option. Aim of study was to assess the effects of pegvisomant and octreotid... | 18,766,168 |
Recombinant oncolytic poliovirus eliminates glioma in vivo without genetic adaptation to a pathogenic phenotype. | Many viruses, either naturally occurring or as a result of genetic manipulation, exhibit conditional replication in transformed cells. This principle is the basis for experimental therapeutic approaches exploiting the oncolytic potential of such agents without the danger of collateral damage to resistant normal tissues... | 18,766,173 |
Treatment of localised resectable neuroblastoma. Results of the LNESG1 study by the SIOP Europe Neuroblastoma Group. | Main objective of this study was to confirm that surgery alone is an effective and safe treatment for localised resectable neuroblastoma except stage 2 with amplified MYCN gene (MYCNA). Of 427 eligible stages 1-2 patients, 411 had normal MYCN and 16 had MYCNA. Of the 288 stage 1 patients with normal MYCN, 1 died of com... | 18,766,186 |
Green tea consumption and lung cancer risk: the Ohsaki study. | We examined the risk of lung cancer in relation to green tea consumption in a population-based cohort study in Japan among 41,440 men and women, aged 40-79 years, who completed a questionnaire in 1994 regarding green tea consumption and other health-related lifestyle factors. During the follow-up period of 7 years (fro... | 18,766,189 |
Early changes in the haemostatic and procoagulant systems after chemotherapy for breast cancer. | Venous thromboembolism (VTE) following breast cancer chemotherapy is common. Chemotherapy-induced alterations in markers of haemostasis occur during chemotherapy. It is unclear how rapidly this occurs, whether this is upregulated in patients developing VTE and whether changes predict for VTE. Markers of haemostasis, fu... | 18,766,191 |
Quantitative evaluation of microvascular density after stroke in rats using MRI. | We investigated vascular changes after stroke using magnetic resonance imaging (MRI) microvascular density (MVD) measurement. T(2) and T(2)(*) were measured in eight rats before and after injecting an intravascular superparamagnetic iron oxide contrast agent to derive the corresponding transverse relaxation shift. Reli... | 18,766,197 |
A mechanistic investigation into the elimination of phosphonium salts from rhodium-TRIPHOS complexes under methanol carbonylation conditions. | Phosphine modified rhodium complexes are currently the topic of considerable research as methanol carbonylation catalysts, but often suffer from poor stability. This paper reports on an investigation into how coordination mode affects the elimination of phosphonium salts from rhodium complexes, namely [trans-RhCl(CO)(P... | 18,766,227 |
Quantum algorithm for obtaining the energy spectrum of molecular systems. | Simulating a quantum system is more efficient on a quantum computer than on a classical computer. The time required for solving the Schrödinger equation to obtain molecular energies has been demonstrated to scale polynomially with system size on a quantum computer, in contrast to the well-known result of exponential sc... | 18,766,235 |
A kinetic model for photoswitching of magnetism in the high spin molecule [Mo(IV)(CN)2(CN-Cu(II)(tren))6](ClO4)8. | The heptanuclear complex [Mo(IV)(CN)2(CN-CuL)6]8+ switches from a paramagnetic dark state corresponding to six spin-1/2 Cu(II) ions to a predominantly high spin S = 3 state, on prolonged irradiation with 406 nm laser radiation at low temperature. The system returns to a paramagnetic state on warming to room temperature... | 18,766,245 |
Clinical implications of aspirin resistance. | Aspirin reduces major atherothrombotic events across a wide spectrum of patients with atherosclerotic disease. The occurrence of ischemic events despite of aspirin treatment is a failure of therapy, often denoted 'clinical aspirin resistance'. This is distinguished from laboratory assays showing an insufficient inhibit... | 18,766,252 |
Should female relatives of factor V Leiden carriers be screened prior to oral contraceptive use? A cost-effectiveness analysis. | Venous thromboembolism (VTE) is three-fold higher among FV Leiden (FVL) carriers receiving oral contraceptives (OCPs) than in the general population. FVL screening, however, is not routinely performed before prescribing OCP, and the cost-effectiveness of this strategy is unknown. A decision tree model was constructed t... | 18,766,261 |
Heparin-induced antibodies and cardiovascular risk in patients on dialysis. | The clinical relevance of heparin-induced antibodies (HIA) in the absence of thrombocytopenia remains to be defined. The aims of this study were (i) to determine the prevalence of HIA in patients treated by dialysis, (ii) to determine the prevalence of thrombocytopenia and heparin-induced thrombocytopenia (HIT), and (i... | 18,766,268 |
[Prevalence of low visual acuity and ophthalmological disorders in six-year-old children from Santa Fe city]. | Changes in children visual acuity that are not treated carry a high risk of irreversible consequences. To determine the prevalence of low visual acuity and to diagnose the ophthalmologic diseases that cause it in six-year-old children from Santa Fe City, Argentina. Observational, descriptive and transversal design. Vis... | 18,766,279 |
Depression, abuse and its relationship to interstitial cystitis. | This study evaluated the prevalence of depression, sexual abuse, and physical abuse among women diagnosed with interstitial cystitis (IC). One hundred forty-one subjects completed the validated Beck's Depression Inventory II Questionnaire (BDI-II) and the validated Drossman Abuse Questionnaire. Ninety-seven (69%) subje... | 18,766,291 |
Nightshift work and fracture risk: the Nurses' Health Study. | Nightshift work suppresses melatonin production and has been associated with an increased risk of major diseases including hormonally related tumors. Experimental evidence suggests that light at night acts through endocrine disruption likely mediated by melatonin. To date, no observational study has addressed the effec... | 18,766,292 |
[Worsening in patients treated in acute stroke units--results of the Austrian Stroke Unit Registry]. | Up to one-third of patients admitted to a hospital due to an ischemic stroke or a transient ischemic attack show clinical worsening of symptoms in the first hours to days after admission. We analyzed on the basis of a large patient group the frequency of minor or major worsening and the possible predictors for worsenin... | 18,766,311 |
Molecular mechanisms underlying the onset of degenerative aortic valve disease. | Morbidity from degenerative aortic valve disease is increasing worldwide, concomitant with the ageing of the general population and the habitual consumption of diets high in calories and cholesterol. Immunohistologic studies have suggested that the molecular mechanism occurring in the degenerate aortic valve resembles ... | 18,766,323 |
Activation of somatostatin receptors in the globus pallidus increases rat locomotor activity and dopamine release in the striatum. | Somatostatin and its receptors have been localized in brain nuclei implicated in motor control, such as the striatum, nucleus accumbens, ventral pallidum, and globus pallidus (GP). The objective of this study was to investigate the role of somatostatin receptors (sst(1,2,4)) in the GP on dopamine (DA)-mediated behavior... | 18,766,330 |
Dose-response effect of serum butyrylcholinesterase activity after clinical doses of pancuronium. | Low-dose pancuronium is known to affect serum cholinesterase activity (BChE); however, the dose-response effect of clinical doses of pancuronium on BChE has not been investigated. Thirteen ASA I-II patients scheduled for elective surgery requiring muscle relaxation were enrolled in this study. All patients had normal B... | 18,766,333 |
Interethnic differences of PEPT2 (SLC15A2) polymorphism distribution and associations with cephalexin pharmacokinetics in healthy Asian subjects. | The aims of this study were to characterize the population frequency of PEPT2 (SLC15A2) polymorphic variants in three Asian ethnic populations, namely Chinese, Malay and Asian Indian, and to investigate the associations of ethnicity (Chinese vs. Asian Indian), PEPT2 haplotype and cephalexin pharmacokinetics in healthy ... | 18,766,334 |
X-ray diffraction analysis of urinary calculi: need for heat treatment. | Although X-ray diffraction (XRD) is the most reliable method for analysis of urinary stones, it has its specific limitations. It fails to detect amorphous phases, cannot distinguish between chemically different phases having identical lattice geometry (e.g., brushite CaHPO4.2H2O and gypsum CaSO4.2H2O) and may miss some... | 18,766,336 |
Weakly nonlinear analysis of a hyperbolic model for animal group formation. | We consider an one-dimensional nonlocal hyperbolic model for group formation with application to self-organizing collectives of animals in homogeneous environments. Previous studies have shown that this model displays at least four complex spatial and spatiotemporal group patterns. Here, we use weakly nonlinear analysi... | 18,766,343 |
Evolution of lamellar macular hole studied by optical coherence tomography. | To study the natural course of lamellar macular hole (LMH) as examined by optical coherence tomography (OCT) in a noncomparative observational case series. Forty-one eyes of 41 patients with LMH were included in this analysis. Baseline and final OCT findings related to LMH diameter, foveal thickness and visual acuity (... | 18,766,367 |
[Posttraumatic gusher phenomenon following fracture of the petrous bone]. | The gusher phenomenon is a very rare complication that may occur during stapedectomy or cochleostomy. A sudden perilymphatic flow of cerebrospinal fluid can be seen following platinotomy. The cause is an abnormal connection between subarachnoid and perilymphatic spaces due to congenital malformation, leading to an abno... | 18,766,399 |
"When strangers meet": John Bowlby and Harry Harlow on attachment behavior. | From 1957 through the mid-1970s, John Bowlby, one of the founders of attachment theory, was in close personal and scientific contact with Harry Harlow. In constructing his new theory on the nature of the bond between children and their caregivers, Bowlby profited highly from Harlow's experimental work with rhesus monke... | 18,766,423 |
Anakinra in the treatment of polyarticular-course juvenile rheumatoid arthritis: safety and preliminary efficacy results of a randomized multicenter study. | This study assessed the safety and preliminary efficacy of the interleukin-1 receptor antagonist anakinra in patients with polyarticular-course juvenile rheumatoid arthritis (JRA). Eighty-six patients entered a 12-week open-label run-in phase (1 mg/kg anakinra daily, < or =100 mg/day). Fifty responders were randomiz... | 18,766,426 |
Major influences on nutrient intake in pregnant New Zealand women. | To investigate factors associated with maternal diet during pregnancy and rank these in order of influence using data from a prospective cohort of 196 pregnant women, aged between 18 and 35 years of mostly European origin. Anthropometric measurements were taken, questionnaires administered and 16 days of weighed diet i... | 18,766,432 |
Bioaccumulation and physiological effects of mercury in Pteris vittata and Nephrolepis exaltata. | Anatomical, histochemical and biochemical approaches were used to study mercury uptake and phytotoxicity as well as anti-oxidative responses in two species of ferns [Chinese brake fern (Pteris vittata) and Boston fern (Nephrolepis exaltata)], grown in a hydroponic system. The roots of both cultivars accumulated large a... | 18,766,440 |
Oxidative stress by Helicobacter pylori causes apoptosis through mitochondrial pathway in gastric epithelial cells. | Helicobacter pylori is a gram negative bacterium that infects the human stomach of approximately half of the world's population. It produces oxidative stress, and mitochondria are one of the possible targets and the major intracellular source of free radicals. The present study was aimed at determining mitochondrial al... | 18,766,443 |
Infectious exposure in the first year of life and risk of central nervous system tumors in children: analysis of day care, social contact, and overcrowding. | Little is known regarding the aetiology of central nervous system tumors in children. Recent studies have speculated on a potential infectious aetiology, but no clear associations have been found. This article uses parent reported questionnaire data from the UK Childhood Cancer Study (UKCCS), a population-based case-co... | 18,766,446 |
Accuracy of retinal changes in predicting microalbuminuria among elderly hypertensive patients: a cross-sectional study from a teaching hospital in South India. | Microalbuminuria is an important marker of end organ damage in hypertensive patients, but is often not tested for, especially in a resource-poor setting. We studied the accuracy of retinal changes in predicting microalbuminuria among a cohort of geriatric hypertensive patients. One hundred and eighty elderly hypertensi... | 18,766,459 |
CCN2 YAPs at cancer. | The YAP transcription coactivator has been implicated as an oncogene and is amplified in human cancers. Previously, it has been shown that CCN2 (connective tissue growth factor, CTGF) is a target of the tumor promoting YAP and its transcription factor target TEAD. A recent report in Genes and Development by Zhao and co... | 18,766,468 |
Efficacy of avian influenza neuraminidase-specific vaccines in chickens. | This paper investigates the protection induced in chickens by live neuraminidase (N)-specific vaccines against highly pathogenic avian influenza. Vaccination with viruses belonging to N1 and N8 subtypes protected against challenge with virulent viruses of the same N subtype and irrelevant haemagglutinin (H) subtypes. T... | 18,766,509 |
Infectious typhlitis in chickens caused by spirochetes. | A weakly haemolytic spirochete was detected with an unabsorbed fluorescent antiserum to Treponema hyodysenteriae in smears and cultures of scrapings of caecal mucosa of laying hens with diarrhoea. Two groups of experimental chickens were fed a pure culture of this spirochete or homogenated intestinal contents of affect... | 18,766,524 |
Pathogenicity of an isolate of Aspergillus flavus in chickens. | Cockerels aged 8 days were each given intraperitoneally a 1 ml suspension of Aspergillus flavus grown on Sabouraud's dextrose agar containing 10(6) colony forming units per ml. No clinical signs were observed but mortality was 37.5%. Liver and kidney were enlarged at necropsy. Granulomatous nodules were found in the se... | 18,766,525 |
Clinical and pathological changes caused by the interaction of lasalocid and chloramphenicol in broiler chickens. | Uncommon and abnormal gait, characterised by toe walking and progressive leg weakness, was observed in a large broiler flock in Israel. Identical clinical signs were reproduced when young chicks received feed supplemented with lasalocid (Abatec-Roche), and chloramphenicol at normal recommended levels, for 12 days or mo... | 18,766,527 |
Pathogenesis of rotavirus infection in turkey poults. | The pathogenesis of rotavirus infection was examined after experimental infection of conventional and specific-pathogen-free (SPF) turkey poults. In six experiments birds were exposed to turkey rotavirus isolates Tu-1 or TU-2 or the chicken isolate Ch-1 at 7, 10 or 42 days of age. Poults were examined between 1 and 24 ... | 18,766,543 |
Demonstration of a Marek's disease virus-specific antigen in tumour lesions of chickens with Marek's disease using monoclonal antibody against a virus phosphorylated protein. | By use of monoclonal antibody against a Marek's disease virus (MDV) serotype 1-specific phosphorylated protein, MDV antigen-positive cells were demonstrated in tumour lesions of various visceral organs of chickens with Marek's disease. However, these tumour lesions did not appear to have the MDV glycoproteins gA and gB... | 18,766,550 |
The differential contribution of B and T lymphocytes to susceptibility to Marek's disease in RPL line-7 chickens. | The nature of genetically determined resistance or susceptibility to Marek's disease (MD) has been investigated further in the two histocompatible chicken strains RPL line-6 (resistant) and line-7 (susceptible). Experiments involving the chemical ablation of host bursa cells and reconstitution with bursa cells from the... | 18,766,557 |
An outbreak of pox among pheasants in Iraq. | Clinical manifestations of pox are described in caged pheasants in Iraq, which killed 28 out of 400 adult pheasants. | 18,766,581 |
Enhancement of natural killer cell activity by Marek's disease vaccines. | Vaccination against Marek's disease with herpesvirus of turkeys (HVT) has been reported to cause increased natural killer (NK) cell activity as detected in vitro against LSCC-RP9 target cells. The effect of vaccination with SB-1 (a nononcogenic chicken herpesvirus), HVT and the HVT/SB-1 combination on NK cell activatio... | 18,766,591 |
The effect of increased sodium in the drinking water on right ventricular hypertrophy, right ventricular failure and ascites in broiler chickens. | One hundred commercial male broiler chickens were grown to 27 days in four floor pens on a commercial diet containing 0.14% sodium (Na+). From day 6 each pen received different levels of sodium chloride (NaCl) in the drinking water; 0.0%, 0.15% (0.06% Na+), 0.3% (0.12% Na+) and 0.6% (0.24% Na+). Eight chicks from each ... | 18,766,592 |
Development of an enzyme-linked immunosorbent assay for the detection of humoral antibody to Pasteurella anatipestifer. | An enzyme-linked immunosorbent assay (ELISA) for the detection of antibodies to Pasteurella anatipestifer in duck sera is described. As part of the initial assay development, micro-titration plates from different manufacturers were assayed for their suitability to bind P. anatipestifer antigen. The Nunc Immunopiate II ... | 18,766,597 |
Outbreak of atypical fowlpox in chickens with persistent reticuloendotheliosis viraemia. | During the Autumn in S/Eastern Australia, eight chickens of 7 months of age with an experimentally-induced reticuloendotheliosis virus (REV) viraemia developed cutaneous manifestations similar to fowlpox. Ten hatchmates housed in a separate pen nearby, and known to be free of REV infection, remained clinically normal. ... | 18,766,601 |
Effect of cyclophosphamide on infections produced by Escherichia coli of high and low virulence in chickens. | The effect of cyclophosphamide (Cy) on infections caused by Escherichia coli strains of high (Expt 1) and low (Expt 2) virulence was examined in 4-week-old specified-pathogen-free chickens. In Expt 1 the mortalities of Cy-treated and non-treated chickens given 5 x 10(7) cfu of a strain of E. coli of high virulence were... | 18,766,611 |
Experimental reproduction of psittacine beak and feather disease/French Moult. | Nestling budgerigars and galahs and one-day-old SPF chickens were inoculated with an homogenate prepared from the feathers of a variety of birds with psittacine beak and feather disease (PBFD), and known to contain virus-like particles 20 nm in diameter. Uninoculated birds were included as in-contact controls and group... | 18,766,613 |
'Cage clutch' in a flock of commercial White Leghorns. | Five commercial White Leghorn chickens were presented to the laboratory from a flock which was experiencing a mortality problem after transfer to the laying house. About 4 or 5% of the birds were 'squatting' in their cages and appeared nervous. Localized, ulcerative lesions were noted on the toes and shanks of the laye... | 18,766,621 |
Production of virus-specific antisera to lymphoproliferative disease virus of turkeys. | Lymphoproliferative disease virus, a recently isolated C-type retro-virus, cannot yet be cultured in cells in vitro and rarely induces a high titre virus-specific antiserum. However, after digestion of purified virus with bromelain and rebanding the treated virus in sucrose gradients bald virions devoid of the viral sp... | 18,766,656 |
Parsley-induced photosensitivity in ostriches and ducks. | Clinical and pathological changes suggesting an acute case of photo-sensitivity were observed in a flock of ostriches. A preliminary diagnosis of parsley (Petroselinum sativum)-induced photosensitisation was confirmed by experimental reproduction of the typical lesions in ducks. This seems to be the first report on nat... | 18,766,676 |
Efficacy of piperazine dihydrochloride against ascaridia galli in the domestic fowl. | The efficacy of piperazine dihydrochloride (Ascarex D, Rexolin Chemicals AB, Helsingborg, Sweden) was evaluated against natural infections of Ascaridia galli in broiler breeders. The compound was administered in the drinking water at a concentration of 1 or 2%. Efficacy against mature A. galli in controlled anthelminti... | 18,766,706 |
Hatchability and mortality following infection of chick embryos with subgroup a Rous sarcoma virus. | An investigation, using Rhode Island Red, New Hampshire, Columbian and Australorp, was conducted to study the correlation between chorioallantoic membrane (CAM)-infection phenotype to challenge with Bryan strain of Rous sarcoma virus (BS-RSV) of subgroup A and subsequent mortality, following hatching. A total of 806 CA... | 18,766,714 |
Natural haemagglutinins and immune responsiveness in young chicks. | Titres of natural haemagglutinins to sheep erythrocytes and of experimentally induced antibodies to Newcastle disease virus (NDV), bovine serum albumin (BSA) and human gammaglobulin (HgG) were determined in White Rock broiler chicks immunised at 28 days of age. There was no relationship between levels of natural haemag... | 18,766,759 |
Normal and clinical haematology of captive cranes (Gruiformes). | Fall blood counts on 56 clinically normal cranes of nine different species have provided reference values for the interpretation of haematological changes in 13 cranes presenting with abnormal clinical signs. Hypochromic anaemia, heterophilia and lymphocytosis were found in birds with probable Mycobacterium avium infec... | 18,766,764 |
Acute toxicity of citrinin in turkeys and ducklings. | Citrinin, a naturally occurring mycotoxin, was dissolved in dimethyl-sulphoxide - 70% ethanol (3:1, v/v) and administered orally in two trials to 7-day-old male turkey poults and male white Pekin ducklings. The single dose LD50 value in 7-day-old male turkey poults was 56 mg/kg and in 7-day-old male white Pekin ducklin... | 18,766,779 |
The role of histocompatibility antigens in cell-mediated cytotoxicity against Marek's disease tumour-derived lymphoblastoid cell lines. | The cytotoxic activity of spleen cells from Marek's disease (MD) virus-infected chickens against syngeneic and allogeneic tumour cell lines was compared, using MD lymphoma-derived lymphoblastoid cell lines obtained from two inbred and two outbred chicken strains. Activity was significantly greater against allogeneic th... | 18,766,805 |
Mycotoxicoses produced in ducklings and turkeys by dietary and multiple doses of citrinin. | Citrinin was mixed in the diet (100, 250, 500 parts/10(6)) and fed to 1-day-old male White Pekin ducklings (Trial I), or it was dissolved in dimethyl-sulphoxide-70% ethanol (3:1, v/v) and administered by crop gavage to 14-day-old male White Pekin ducklings (Trial II) or 7-day-old male turkey poults (Trial III). Ducklin... | 18,766,819 |
The pathogenicity of some avian reoviruses with particular reference to tenosynovitis. | In two experiments, 13 avian reoviruses from different sources were tested in specific pathogen-free (SPF) light hybrid chicks at 1-day-old for their pathogenicity with particular respect to tenosynovitis. All strains including two from commercial ducks and another from a wedge-tail eagle caused tenosynovitis. In most ... | 18,766,835 |
Lymphoproliferative disease of turkeys: effect of chemical and surgical bursectomy on viraemia, pathogenesis and on the humoral immune response. | Turkey poults which were surgically or chemically bursectomised after hatching, and inoculated with the lymphoproliferative disease (LPD) virus at 3(1/2) weeks of age, developed typical tumourous lesions in various organs (pancreas, spleen, thymus, liver, gonads and kidneys) to the same extent as intact but inoculated ... | 18,766,844 |
Avian cellular immune effector mechanisms--a review. | Considerable new knowledge has accumulated within the last few years on the immune functions of birds, and data show that the avian cellular immune effector mechanisms are quite similar to those of mammals. Cellular immunity in the chicken, the most widely studied avian species, is primarily mediated by T cells, macrop... | 18,766,854 |
Eimeria necatrix: selection and characteristics of a precocious (and attenuated) line. | A line of Eimeria necatrix with an abbreviated life cycle (i.e. a "precocious" line) was derived from the Houghton laboratory strain by repeated passage of the oocysts which were the first to be recovered from infections in chickens. The precocious line had a reproductive potential much lower than that of its parent st... | 18,766,877 |
Subsets and Splits
No community queries yet
The top public SQL queries from the community will appear here once available.