title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Analysis of thyreostatic drugs in thyroid samples by liquid chromatography tandem mass spectrometry: comparison of two sample treatment strategies. | A method based on ultra-performance liquid chromatography-electrospray ionisation-tandem mass spectrometry (UPLC-MS/MS) for the determination of six thyreostatic drugs in thyroid tissue has been optimised and validated in accordance with Decision 2002/657/EC. Sample extraction was evaluated in methanol and in ethyl ace... | 18,768,184 |
Genetic diversity in the yellow head nidovirus complex. | Penaeus monodon shrimp collected from across the Indo-Pacific region during 1997-2004 were screened for the presence of yellow head-related viruses. Phylogenetic analyses of amplified ORF1b gene segments identified at least six distinct genetic lineages (genotypes). Genotype 1 (YHV) was detected only in shrimp with yel... | 18,768,192 |
Putative gene promoter sequences in the chlorella viruses. | Three short (7 to 9 nucleotides) highly conserved nucleotide sequences were identified in the putative promoter regions (150 bp upstream and 50 bp downstream of the ATG translation start site) of three members of the genus Chlorovirus, family Phycodnaviridae. Most of these sequences occurred in similar locations within... | 18,768,195 |
Toxicity assessment of manufactured nanomaterials using the unicellular green alga Chlamydomonas reinhardtii. | With the rapid development of nanotechnology, there is an increasing risk of human and environmental exposure to nanotechnology-based materials and products. As water resources are particularly vulnerable to direct and indirect contamination of nonomaterials (NMs), the potential toxicity and environmental implication o... | 18,768,203 |
Reproducing stone monument photosynthetic-based colonization under laboratory conditions. | In order to understand the biodeterioration process occurring on stone monuments, we analyzed the microbial communities involved in these processes and studied their ability to colonize stones under controlled laboratory experiments. In this study, a natural green biofilm from a limestone monument was cultivated, inocu... | 18,768,211 |
Engineered extracellular matrices with cleavable crosslinkers for cell expansion and easy cell recovery. | An unmet need for expansion of primary cells and progenitor cells in three dimensions (3-D) is a synthetic mimic of the extracellular matrix (ECM) with user-controllable composition that would permit rapid recovery of viable cells under mild, non-enzymatic conditions. Three block copolymers based on disulfide-containin... | 18,768,219 |
Pre-operative chemoradiotherapy with UFT and Leucovorin in patients with advanced rectal cancer: a phase II study. | The aim this study was to determine the pathologic complete response (pCR) rate defined as tumor regression grade 1 (TRG1) and toxicity profile of the combination of high-dose pre-operative radiotherapy and simultaneous UFT/leucovorin (LV) in patients with locally advanced rectal cancer. Eligibility included biopsy pro... | 18,768,230 |
Radiological hazards of Narghile (hookah, shisha, goza) smoking: activity concentrations and dose assessment. | Narghile (hookah, shisha, goza, "water-pipe") smoking has become fashionable worldwide. Its tobacco pastes, known as moassel and jurak, are not standardized and generally contain about 30-50% (sometimes more) tobacco, molasses/juice of sugarcane, various spices and dried fruits (particularly in jurak) and, in the case ... | 18,768,240 |
Removal of COD from laundry wastewater by electrocoagulation/electroflotation. | The removal efficiency of COD in the treatment of simulated laundry wastewater using electrocoagulation/electroflotation technology is described. The experimental results showed that the removal efficiency was better, reaching to about 62%, when applying ultrasound to the electrocoagulation cell. The solution pH approa... | 18,768,252 |
Design of a neutral electro-Fenton system with Fe@Fe(2)O(3)/ACF composite cathode for wastewater treatment. | The narrow pH range limits the wide application of Fenton reaction in the wastewater treatment. It is of great importance to widen working pH range of Fenton reaction from strong acidic condition to neutral, even basic ones. In this study, for the first time nanostructured Fe@Fe(2)O(3) was loaded on active carbon fiber... | 18,768,254 |
The language of schizophrenia: an analysis of micro and macrolinguistic abilities and their neuropsychological correlates. | Language disturbance is one of the main diagnostic features in schizophrenia and abnormalities of brain language areas have been consistently found in schizophrenic patients. The main aim of this study was to describe the impairment of micro and macrolinguistic abilities in a group of twenty-nine schizophrenic patients... | 18,768,300 |
Circulating endothelial cells, bone marrow-derived endothelial progenitor cells and proangiogenic hematopoietic cells in cancer: From biology to therapy. | Vascularization, a hallmark of tumorigenesis, is classically thought to occur exclusively through angiogenesis (i.e. endothelial sprouting). However, there is a growing body of evidence that endothelial progenitor cells (EPCs) and proangiogenic hematopoietic cells (HCs) are able to support the vascularization of tumors... | 18,768,327 |
Potential effects of chondroitin sulfate on joint swelling: a GAIT report. | The Glucosamine/chondroitin Arthritis Intervention Trial (GAIT) was a randomized double-blind placebo and active comparator (celecoxib) controlled trial of 1583 persons with symptomatic osteoarthritis (OA) of the knee(1). Patients randomized to celecoxib had significant improvement in knee pain compared to those random... | 18,768,335 |
Supplementation with a whey protein hydrolysate enhances recovery of muscle force-generating capacity following eccentric exercise. | There is evidence that protein hydrolysates can speed tissue repair following damage and may therefore be useful for accelerating recovery from exercise induced muscle damage. The potential for a hydrolysate (WPI(HD)) of whey protein isolate (WPI) to speed recovery following eccentric exercise was evaluated by assessin... | 18,768,358 |
Direct observation measurement of drowning risk exposure for surf beach bathers. | Because not all persons bathe at surf beaches, drowning rates based on resident population are likely to be underreported. To facilitate more precise drowning risk exposure data, this study aimed to develop a reliable direct observation measure of frequency and duration for surf beach bather exposure to water, by gende... | 18,768,365 |
Plant microRNA detection using the circular code information. | In this paper we present a new computational method leading to the identification of a new property in the plant microRNAs. This property which is based on the circular code information is then used to detect microRNAs in plants. The common C(3) circular code X is a set of 20 trinucleotides identified in the reading fr... | 18,768,373 |
In vitro biocompatibility and bacterial adhesion of physico-chemically modified Ti6Al4V surface by means of UV irradiation. | UV irradiation leads to a "spontaneous" wettability increase of the Ti6Al4V surface while preserving bulk properties of the alloy that are crucial for its performance as an orthopedic and dental implant. We hypothesized that UV treatment of Ti6Al4V may impair bacterial adhesion without compromising the good response of... | 18,768,375 |
Contrasting response to Pleistocene climate change by ground-living and arboreal Mandarina snails from the oceanic Hahajima archipelago. | While the genetic impact of Pleistocene climate change on temperate species has been well characterized, especially in Europe and North America, an effect on the diversification of species on oceanic islands has been less well studied. This is perhaps a surprising observation given the traditional and continuing contri... | 18,768,383 |
Mechanistic differences between GSH transport by multidrug resistance protein 1 (MRP1/ABCC1) and GSH modulation of MRP1-mediated transport. | Multidrug resistance protein 1 (MRP1/ABCC1) is an ATP-dependent polytopic membrane protein that transports many anticancer drugs and organic anions. Its transport mechanism is multifaceted, especially with respect to the participation of GSH. For example, vincristine is cotransported with GSH, estrone sulfate transport... | 18,768,387 |
Bone marrow microenvironment controls the in vivo differentiation of murine dendritic cells into osteoclasts. | Finding that activated T cells control osteoclast (OCL) differentiation has revealed the importance of the interactions between immune and bone cells. Dendritic cells (DCs) are responsible for T-cell activation and share common precursors with OCLs. Here we show that DCs participate in bone resorption more directly tha... | 18,768,394 |
Immediate postnatal growth is associated with blood pressure in young adulthood: the Barry Caerphilly Growth Study. | There is a consistent inverse association between birth weight and systolic blood pressure; however, few studies have been able to examine the immediate postnatal period. We have examined whether accelerated postnatal growth predicts adult systolic and diastolic blood pressure. We followed up participants from the Barr... | 18,768,401 |
Intravenous morphine can avoid distressing constipation associated with oral morphine: a retrospective analysis of our experience in 11 patients in the palliative care in-patient unit. | Morphine is the preferred strong opioid analgesic. Most of the adverse effects, such as daytime drowsiness, dizziness, mental clouding, and effects on cognitive and psychomotor function or nausea and vomiting, usually resolve with time. The main continuing adverse effect of morphine is constipation, and prophylactic us... | 18,768,425 |
Phase III, double-blind study of depot octreotide versus placebo in the prevention of acute diarrhea in patients receiving pelvic radiation therapy: results of North Central Cancer Treatment Group N00CA. | To assess the effectiveness of depot octreotide for the prevention of diarrhea during pelvic radiation therapy. Patients receiving pelvic radiation therapy (planned minimum dose, 45 Gy; 1.7 to 2.1 Gy daily) were eligible for the study. From May 10, 2002, through October 14, 2005, 125 patients were randomly allocated in... | 18,768,432 |
Leadership development for dental students: what do students think? | Effective leaders are needed to move the dental profession forward, building on past accomplishments, meeting new challenges, and leading innovation and change. There is a lack of research findings regarding students' perceptions of the importance of leadership abilities and/or their interest in developing leadership s... | 18,768,440 |
Developing a standardized cephalometric vocabulary: choices and possible strategies. | The science of cephalometry has been invaluable for guiding orthodontic diagnosis, treatment planning, and outcomes tracking. Though software packages easily calculate most cephalometric measurements, the ability to exchange cephalometric data between software packages is poorly developed. Hindering this effort is the ... | 18,768,441 |
Dental hygiene education about patients with special needs: a survey of U.S. programs. | The objective of this study was to explore how dental hygiene programs in the United States educate their students about treating patients with special needs. Data were collected from 102 U.S. dental hygiene programs (response rate=49 percent) with a web-based survey. Nearly all programs (98 percent) reported that they... | 18,768,443 |
Electronic voting in dental materials education: the impact on students' attitudes and exam performance. | Dental materials is an integral part of any undergraduate dental curriculum and is most commonly taught in a traditional didactic, lecture-based format. It suffers from the ignominy of being viewed by many as a dry, factual subject with little to excite or engage the student. In this article, the author presents the ex... | 18,768,446 |
Effect of charcoal-containing cigarette filters on gas phase volatile organic compounds in mainstream cigarette smoke. | Of the chemicals identified to date in mainstream cigarette smoke with known toxicological properties, the volatile organic compounds (VOCs) are considered the most hazardous group owing to their high abundance and toxicity. In this research we evaluate a recently introduced line of cigarettes that contain charcoal in ... | 18,768,454 |
The feasibility of measuring puffing behaviour in roll-your-own cigarette smokers. | Despite the increase in roll-your-own (RYO) cigarette consumption in many countries, very little is known about RYO smokers. In order to estimate the health risks inherent in RYO use, it is important to assess exposure to tobacco toxins in this group. Exposure is determined by a number of factors, including puffing beh... | 18,768,455 |
Two patched protein subtypes and a conserved domain of group I proteins that regulates turnover. | Patched (Ptc) is a 12-cross membrane protein that binds the secreted Hedgehog protein. Its regulation of the Hedgehog signaling pathway is critical to normal development and to a number of human diseases. This report analyzes features of sequence similarity and divergence in the Ptc protein family and identifies two su... | 18,768,465 |
The motor complex of Plasmodium falciparum: phosphorylation by a calcium-dependent protein kinase. | Calcium-dependent protein kinases (CDPKs) of Apicomplexan parasites are crucial for the survival of the parasite throughout its life cycle. CDPK1 is expressed in the asexual blood stages of the parasite, particularly late stage schizonts. We have identified two substrates of Plasmodium falciparum CDPK1: myosin A tail d... | 18,768,477 |
Novel mechanism for suppression of hyperpolarization-activated cyclic nucleotide-gated pacemaker channels by receptor-like tyrosine phosphatase-alpha. | We have previously reported an important role of increased tyrosine phosphorylation activity by Src in the modulation of hyperpolarization-activated cyclic nucleotide-gated (HCN) channels. Here we provide evidence showing a novel mechanism of decreased tyrosine phosphorylation on HCN channel properties. We found that t... | 18,768,480 |
Differential expression of parathyroid hormone-related protein in adrenocortical tumors: autocrine/paracrine effects on the growth and signaling pathways in H295R cells. | Adrenocortical tumors (ACT) are rare and heterogeneous, but their pathogenesis is unclear. The oncoprotein parathyroid hormone-related protein (PTHrP), found in many common tumors, can regulate their growth in an autocrine/paracrine fashion through the PTH-R1 receptor. Little is known about the role of PTHrP in ACT. We... | 18,768,493 |
Residential traffic density and childhood leukemia risk. | Exposures to carcinogenic compounds from vehicle exhaust may increase childhood leukemia risk, and the timing of this exposure may be important. We examined the association between traffic density and childhood leukemia risk for three time periods: birth, time of diagnosis, and lifetime average, based on complete resid... | 18,768,496 |
Mitochondrial genetic polymorphisms do not predict survival in patients with pancreatic cancer. | Pancreatic cancer is a highly lethal malignancy, and the majority of patients succumb to the disease within 2 years. We evaluated the role of variants of mitochondrial DNA and mitochondrial haplogroups in predicting prognosis of patients with pancreatic cancer. A total of 24 mitochondrial single nucleotide polymorphism... | 18,768,524 |
Controlling alpha-globin: a review of alpha-globin expression and its impact on beta-thalassemia. | Synthesis of alpha-globin and alpha-globin subunits of hemoglobin occurs at high levels during erythrocyte differentiation in a tightly controlled and coordinated fashion. Expression of alpha-globin is a fascinatingly complex process which has been meticulously defined in several recent studies, from chromatin modifica... | 18,768,527 |
'MetLife V. Glenn': the Court addresses a conflict over conflicts in ERISA benefit administration. | In its June 2008 decision in MetLife v. Glenn, the Supreme Court held that federal courts reviewing claim denials by Employee Retirement Income Security Act (ERISA) employee benefit plan administrators should take into account the fact that plan administrators (insurers or self-insured plans) face a conflict of interes... | 18,768,537 |
Gender, health inequalities and welfare state regimes: a cross-national study of 13 European countries. | This study is the first to examine the relationship between gender and self-assessed health (SAH), and the extent to which this varies by socioeconomic position in different European welfare state regimes (Liberal, Corporatist, Social Democratic, Southern). The EUROTHINE harmonised data set (based on representative cro... | 18,768,570 |
Accelerated senescence in the kidneys of patients with type 2 diabetic nephropathy. | We examined the hypothesis that senescence represents a proximate mechanism by which the kidney is damaged in type 2 diabetic nephropathy (DN). As a first step, we studied whether the senescence-associated beta-galactosidase (SA-beta-Gal) and the cell cycle inhibitor p16INK4A are induced in renal biopsies from patients... | 18,768,588 |
List of new names and new combinations previously effectively, but not validly, published. | The purpose of this announcement is to effect the valid publication of the following effectively published new names and new combinations under the procedure described in the Bacteriological Code (1990 Revision). Authors and other individuals wishing to have new names and/or combinations included in future lists should... | 18,768,592 |
Roseomonas vinacea sp. nov., a Gram-negative coccobacillus isolated from a soil sample. | Strain CPCC 100056(T), which was isolated from a soil sample collected from the Qinghai-Tibet plateau, China, was subjected to a polyphasic taxonomic study. The organism was coccobacillus-shaped, non-motile and formed vinaceous colonies on ISP2 agar medium. The respiratory quinone was ubiquinone-10. The major fatty aci... | 18,768,606 |
Paenibacillus konsidensis sp. nov., isolated from a patient. | A Gram-positive, rod-shaped bacterium, designated strain LBY(T), was isolated from the blood of a Korean patient. The organism could not be identified based on conventional clinical microbiological methods. 16S rRNA gene sequencing and phylogenetic analysis revealed that it belonged to the genus Paenibacillus, but was ... | 18,768,623 |
Reclassification of the genus Leuconostoc and proposals of Fructobacillus fructosus gen. nov., comb. nov., Fructobacillus durionis comb. nov., Fructobacillus ficulneus comb. nov. and Fructobacillus pseudoficulneus comb. nov. | A taxonomic study was made of the genus Leuconostoc. The species in the genus were divided into three subclusters by phylogenetic analysis based on the 16S rRNA gene sequences. The three subclusters were the Leuconostoc mesenteroides subcluster (comprising L. carnosum, L. citreum, L. gasicomitatum, L. gelidum, L. inhae... | 18,768,629 |
Steroidobacter denitrificans gen. nov., sp. nov., a steroidal hormone-degrading gammaproteobacterium. | A denitrifying bacterium, designated strain FS(T), was isolated from anoxic digested sludge on oestradiol [17beta-oestra-1,3,5(10)-triene-3,17-diol] or testosterone (17beta-hydroxyandrost-4-en-3-one) as the sole source of carbon and energy with nitrate as the electron acceptor. Strain FS(T) represents the first known b... | 18,768,632 |
DSCF neurons within the primary auditory cortex of the mustached bat process frequency modulations present within social calls. | Neurons in the Doppler-shifted constant frequency processing (DSCF) area in the primary auditory cortex of mustached bats, Pteronotus parnellii, are multifunctional, responding both to echolocation and communication sounds. Simultaneous presentation of a DSCF neuron's best low and high frequencies (BF(low) and BF(high)... | 18,768,643 |
The human dorsal stream adapts to real actions and 3D shape processing: a functional magnetic resonance imaging study. | We tested whether the control of real actions in an ever-changing environment would show any dependence on prior actions elicited by instructional cues a few seconds before. To this end, adaptation of the functional magnetic resonance imaging signal was measured while human participants sequentially grasped three-dimen... | 18,768,646 |
Detection of perinatal cytomegalovirus infection and sensorineural hearing loss in belgian infants by measurement of automated auditory brainstem response. | Since auditory disability causes serious problems in the development of speech and in the total development of a child, it is crucial to diagnose possible hearing impairment as soon as possible after birth. This study evaluates the neonatal hearing screening program in Flanders, Belgium. The auditory ability of 118,438... | 18,768,656 |
NMDA receptor blockade maintains correlated motor neuron firing and delays synapse competition at developing neuromuscular junctions. | Mammalian neuromuscular synapses undergo an activity-dependent competitive transition from multiple to single innervation during postnatal life. The presence of temporally correlated motor neuron activity, which, in part, is controlled by gap junctional coupling within the spinal cord, appears to modulate synapse elimi... | 18,768,692 |
Whole-brain voxel-based morphometry in Kallmann syndrome associated with mirror movements. | There are 2 main hypotheses concerning the cause of mirror movements (MM) in Kallmann syndrome (KS): abnormal development of the primary motor system, involving the ipsilateral corticospinal tract; and lack of contralateral motor cortex inhibitory mechanisms, mainly through the corpus callosum. The purpose of our study... | 18,768,731 |
Physical interaction of calmodulin with the 5-hydroxytryptamine2C receptor C-terminus is essential for G protein-independent, arrestin-dependent receptor signaling. | The serotonin (5-hydroxytryptamine; 5-HT)(2C) receptor is a G protein-coupled receptor (GPCR) exclusively expressed in CNS that has been implicated in numerous brain disorders, including anxio-depressive states. Like many GPCRs, 5-HT(2C) receptors physically interact with a variety of intracellular proteins in addition... | 18,768,750 |
Opposing activities of the Snx3-retromer complex and ESCRT proteins mediate regulated cargo sorting at a common endosome. | Endocytosed proteins are either delivered to the lysosome to be degraded or are exported from the endosomal system and delivered to other organelles. Sorting of the Saccharomyces cerevisiae reductive iron transporter, composed of the Fet3 and Ftr1 proteins, in the endosomal system is regulated by available iron; in iro... | 18,768,754 |
Thermal tolerance of contractile function in oxidative skeletal muscle: no protection by antioxidants and reduced tolerance with eicosanoid enzyme inhibition. | Mechanisms for the loss of muscle contractile function in hyperthermia are poorly understood. This study identified the critical temperature, resulting in a loss of contractile function in isolated diaphragm (thermal tolerance), and then tested the hypotheses 1) that increased reactive oxygen species (ROS) production c... | 18,768,765 |
Using kindergarten number sense to predict calculation fluency in second grade. | Children's number sense in kindergarten was used to predict their calculation fluency in second grade (N = 198). Using block entry regression, usual predictors of age, reading, memory, and verbal and spatial cognition were entered in the first block and number sense measures were added in the second block. Number sense... | 18,768,776 |
Forest commons and local enforcement. | This article examines the relationship between local enforcement and forests used as commons. It uses a unique multicountry dataset, created over the past 15 years by the International Forestry Resources and Institutions Research Program. Drawing on original enforcement and forest commons data from 9 countries, we find... | 18,768,821 |
Macrophage polarization in bacterial infections. | Converging studies have shown that M1 and M2 macrophages are functionally polarized in response to microorganisms and host mediators. Gene expression profiling of macrophages reveals that various Gram-negative and Gram-positive bacteria induce the transcriptional activity of a "common host response," which includes gen... | 18,768,823 |
Staphylococcus aureus-induced plasmacytoid dendritic cell activation is based on an IgG-mediated memory response. | Type I IFNs represent a major antimicrobial defense mechanism due to their property of enhancing immune responses by priming both innate and adaptive immune cells. Plasmacytoid dendritic cells (pDC) are the major source of type I IFN in the human body and represent innate immune cells involved in first-line defense aga... | 18,768,836 |
Inside-out regulation of Fc alpha RI (CD89) depends on PP2A. | To achieve a correct cellular immune response toward pathogens, interaction between FcR and their ligands must be regulated. The Fc receptor for IgA, FcalphaRI, is pivotal for the inflammatory responses against IgA-opsonized pathogens. Cytokine-induced inside-out signaling through the intracellular FcalphaRI tail is im... | 18,768,864 |
Trafficking of antigen-specific CD8+ T lymphocytes to mucosal surfaces following intramuscular vaccination. | A critical goal of vaccine development for a wide variety of pathogens is the induction of potent and durable mucosal immunity. However, it has been assumed that this goal would be difficult to achieve by systemic vaccination due to the anatomic and functional distinctness of the systemic and mucosal immune systems and... | 18,768,876 |
Elevated numbers of Fc gamma RIIIA+ (CD16+) effector CD8 T cells with NK cell-like function in chronic hepatitis C virus infection. | CTL are crucial in the defense against viral infections. In the course of investigating peripheral blood and intrahepatic CD8 T cells in patients with chronic hepatitis C virus (HCV) infection, we observed a significant population of CD8 T cells expressing the FcgammaRIIIA (CD16) receptor. This observation led us to ch... | 18,768,879 |
Serum amyloid A induces CCL2 production via formyl peptide receptor-like 1-mediated signaling in human monocytes. | Although the presence of an elevated level of serum amyloid A (SAA) has been regarded as a cardiovascular risk factor, the role of SAA on the progress of atherosclerosis has not been fully elucidated. In the present study, we investigated the effect of SAA on the production of CCL2, an important mediator of monocyte re... | 18,768,891 |
Rapid deletional peripheral CD8 T cell tolerance induced by allogeneic bone marrow: role of donor class II MHC and B cells. | Mixed chimerism and donor-specific tolerance are achieved in mice receiving 3 Gy of total body irradiation and anti-CD154 mAb followed by allogeneic bone marrow (BM) transplantation. In this model, recipient CD4 cells are critically important for CD8 tolerance. To evaluate the role of CD4 cells recognizing donor MHC cl... | 18,768,896 |
4-1BB enhances proliferation of beryllium-specific T cells in the lung of subjects with chronic beryllium disease. | In contrast to naive T cells, reactivation of memory cells is less dependent on CD28-mediated costimulation. We have shown that circulating beryllium-specific CD4(+) T cells from chronic beryllium disease patients remain CD28-dependent, while those present in the lung no longer require CD28 for T cell activation. In th... | 18,768,897 |
Artificial fertilization by intracytoplasmic sperm injection in a teleost fish, the medaka (Oryzias latipes). | Intracytoplasmic sperm injection (ICSI) is a technique that has been successfully used for assisting reproduction in mammals. However, this method is still not reliable in nonmammalian species, including teleosts. We succeeded in producing medaka individuals by ICSI with a rate of 13.4% (28 hatched embryos out of 209 e... | 18,768,915 |
Chondroitin-4-sulfation negatively regulates axonal guidance and growth. | Glycosaminoglycan (GAG) side chains endow extracellular matrix proteoglycans with diversity and complexity based upon the length, composition and charge distribution of the polysaccharide chain. Using cultured primary neurons, we show that specific sulfation in the GAG chains of chondroitin sulfate mediates neuronal gu... | 18,768,934 |
Communication between key stakeholders within a medical home: a qualitative study. | The objective of this study was to determine perceived benefits, detriments, and barriers to communication between pediatric providers and home visitors. The authors performed a cross-sectional, qualitative study consisting of 3 focus groups with paraprofessional home visitors (n=12), 6 with parents receiving home visi... | 18,768,937 |
Efficient subgroup C avian sarcoma and leukosis virus receptor activity requires the IgV domain of the Tvc receptor and proper display on the cell membrane. | We recently identified and cloned the receptor for subgroup C avian sarcoma and leukosis viruses [ASLV(C)], i.e., Tvc, a protein most closely related to mammalian butyrophilins, which are members of the immunoglobulin protein family. The extracellular domain of Tvc contains two immunoglobulin-like domains, IgV and IgC,... | 18,768,966 |
The interferon antagonist ML protein of thogoto virus targets general transcription factor IIB. | The ML protein of Thogoto virus, a tick-transmitted orthomyxovirus, is a splice variant of the viral matrix protein and antagonizes the induction of antiviral type I interferon (IFN). Here we identified the general RNA polymerase II transcription factor IIB (TFIIB) as an ML-interacting protein. Overexpression of TFIIB ... | 18,768,974 |
Identification of monomorphic and divergent haplotypes in the 2006-2007 norovirus GII/4 epidemic population by genomewide tracing of evolutionary history. | Our norovirus (NoV) surveillance group reported a >4-fold increase in NoV infection in Japan during the winter of 2006-2007 compared to the previous winter. Because the increase was not linked to changes in the surveillance system, we suspected the emergence of new NoV GII/4 epidemic variants. To obtain information ... | 18,768,979 |
Molecular and transmission characteristics of primary-passaged ovine scrapie isolates in conventional and ovine PrP transgenic mice. | A more complete assessment of ovine prion strain diversity will be achieved by complementing biological strain typing in conventional and ovine PrP transgenic mice with a biochemical analysis of the resultant PrPSc. This will provide a correlation between ovine prion strain phenotype and the molecular nature of differe... | 18,768,980 |
Growth determinants for H5N1 influenza vaccine seed viruses in MDCK cells. | H5N1 influenza A viruses are exacting a growing human toll, with more than 240 fatal cases to date. In the event of an influenza pandemic caused by these viruses, embryonated chicken eggs, which are the approved substrate for human inactivated-vaccine production, will likely be in short supply because chickens will be ... | 18,768,983 |
Eastern and Venezuelan equine encephalitis viruses differ in their ability to infect dendritic cells and macrophages: impact of altered cell tropism on pathogenesis. | Eastern and Venezuelan equine encephalitis viruses (EEEV and VEEV, respectively) cause severe morbidity and mortality in equines and humans. Like other mosquito-borne viruses, VEEV infects dendritic cells (DCs) and macrophages in lymphoid tissues, fueling a serum viremia and facilitating neuroinvasion. In contrast, EEE... | 18,768,986 |
Transactivation of the hepatitis B virus core promoter by the nuclear receptor FXRalpha. | Hepatitis B virus (HBV) core promoter activity is positively and negatively regulated by nuclear receptors, a superfamily of ligand-activated transcription factors, via cis-acting sequences located in the viral genome. In this study, we investigated the role of farnesoid X receptor alpha (FXRalpha) in modulating transc... | 18,768,987 |
Relationships between colleges of pharmacy and academic medical centers. | The nature of the relationships between academic medical centers and colleges of pharmacy, particularly in respect to experiential education, was studied. A 22-item questionnaire was developed to assess the extent and type of student experiences academic medical centers offered, the presence of a contractual agreement,... | 18,769,003 |
Anterior cruciate ligament reconstruction grafts: MR imaging features at long-term follow-up--correlation with functional and clinical evaluation. | To assess the presence of increased intrasubstance signal intensity within anterior cruciate ligament (ACL) grafts and to assess whether such signal intensity changes are correlated to clinical assessments of graft instability and patient function 4-12 years after ACL reconstruction. Ethical permission and written info... | 18,769,016 |
Peripheral MR angiography with blood pool contrast agent: prospective intraindividual comparative study of high-spatial-resolution steady-state MR angiography versus standard-resolution first-pass MR angiography and DSA. | To prospectively compare the accuracy of high-spatial-resolution steady-state magnetic resonance (MR) angiography with standard-resolution first-pass MR angiography in the lower extremities, with digital subtraction angiography (DSA) as the reference standard. Institutional ethics committee approval and written informe... | 18,769,017 |
Efficacy and safety of Chinese black tea (Pu-Ehr) extract in healthy and hypercholesterolemic subjects. | Water-extracted Chinese black tea (Pu-Ehr) exerts a precipitating effect on mixed bile salt micelles in foods. The amount of black tea extract (BTE) effective for hypercholesterolemia (HC) was examined in humans. Animals (test 1) and humans (tests 2-5) were given BTE in the following studies: (test 1) an acute 2-week t... | 18,769,024 |
Anticancer properties of 2-piperidyl analogues of the natural indole phytoalexin 1-methoxyspirobrassinol. | Several indole phytoalexins exhibit antiproliferative and/or cancer chemopreventive properties in vitro. However, the potency and selectivity of their anticancer effects were reported to be relatively weak. In order to improve the anticancer activity of the natural phytoalexin 1-methoxyspirobrassinol, its new 2-amino a... | 18,769,026 |
Hypoxia increases activity of the BK-channel in the inner mitochondrial membrane and reduces activity of the permeability transition pore. | Hypoxia can cause severe damage to cells by initiating signaling cascades that lead to cell death. A cellular oxygen sensor, other than the respiratory chain, might exist in sensitive components of these signaling cascades. Recently, we found evidence that mitochondrial ion channels are sensitive to low levels of oxyge... | 18,769,039 |
Chondroitin sulfates act as extracellular gating modifiers on voltage-dependent ion channels. | Chondroitin sulfates are glycosaminoglycans bound to core proteins of proteoglycans in the extracellular matrix and perineuronal nets surrounding many types of neurones. Chondroitin 4- and chondroitin 6- sulfate can bind calcium ions with different affinities, depending on their sulfation position. Extracellular calciu... | 18,769,040 |
Nongenomic effect of aldosterone on ion transport pathways of red blood cells. | The direct influence of aldosterone on the human and avian red blood cell (RBC) transport systems, Na(+)/K(+) pump, Na(+),K(+),2Cl(-) symporter, and K(+) (Na(+))/H(+) exchanger, was investigated with tracer kinetics. The present work proved that aldosterone has no significant effect on these transport pathways. However... | 18,769,054 |
Hemangiopoietin promotes endothelial cell proliferation through PI-3K/Akt pathway. | Hemangiopoietin (HAPO) is a novel human growth factor acting on the primitive cells of both hematopoietic and endothelial cell lineages. Our previous study has shown that HAPO exerts a proliferative effect on endothelial cells. However, the mechanism of this action remains unclear. Thus, we studied the signal transduct... | 18,769,058 |
Midazolam for caudal analgesia in children: comparison with caudal bupivacaine. | Caudal analgesia is the most popular and commonly used regional anaesthesia technique for post operative analgesia in children undergoing lower limb, anoperineal and abdominal surgical procedures. It is commonly applied in all the paediatric patients undergoing the above mentioned surgery, as the goal of balanced anaes... | 18,769,080 |
Clinical spectrum of patients presenting with bronchiectasis in Nepal: evidence of linkage between tuberculosis, tobacco smoking and toxic exposure to biomass smoke. | The aim of the study was to describe the clinical spectrum of the patients presenting with bronchiectasis at the referral clinic for the respiratory diseases in eastern Nepal. An attempt would also be made to provide an overview of factors responsible for poor lung health in the community. This is a retrospective obser... | 18,769,086 |
Sexual and reproductive health status among young peoples in Nepal: opportunities and barriers for sexual health education and services utilization. | This article attempts to summarise the situation of sexual and reproductive health among young people in Nepal. Modernisation and social transformation are occurring rapidly in Nepalese society. Growing expansion of communication and transportation networks, urbanisation and in-migration of population to urban areas is... | 18,769,100 |
Enhancement of tumor-TRAIL susceptibility by modulation of autophagy. | Autophagy has recently been recognized as an important cellular response to stress. However, the prospect of manipulating the autophagic process for the enhancement of cancer therapy remains unresolved. This lack of resolution stems from the current controversy regarding the fundamental function of autophagy in tumor s... | 18,769,107 |
Knockdown of RCK/p54 expression by RNAi inhibits proliferation of human colorectal cancer cells in vitro and in vivo. | Colorectal cancer is the third most common cancer in both men and women around the world. Although much progress of the mechanism of colorectal carcinogenesis has been made, the studies centering on the mechanisms of tumorigenesis are much needed to be further exploited. The overexpression of RCK/p54 gene, a member of ... | 18,769,115 |
The yin and yang of the Cdkn2a locus in senescence and aging. | Senescence of cultured cells involves activation of the p19(Arf)-p53 and the p16(Ink4a)-Rb tumor suppressor pathways. This, together with the observation that p19(Arf) and p16(Ink4a) expression increases with age in many tissues of humans and rodents, led to the speculation that these pathways drive in vivo senescence ... | 18,769,141 |
Dissecting the localization and function of Atg18, Atg21 and Ygr223c. | Atg18p and Atg21p are two highly homologous yeast autophagy proteins. Atg18p functions in both autophagy and the selective Cvt-pathway, while the function of Atg21p is restricted to the Cvt-pathway. The yeast genome encodes with Ygr223cp (Hsv2p), a third member of this protein family. So far no function has been assign... | 18,769,150 |
Functions of ocular surface mucins in health and disease. | The purpose of the present review is to describe new concepts on the role of mucins in the protection of corneal and conjunctival epithelia and to identify alterations of mucins in ocular surface diseases. New evidence indicates that gel-forming and cell surface-associated mucins contribute differently to the protectio... | 18,769,205 |
Neuropathies in the context of malignancies. | To conduct a critical review of recent data pertaining to the clinical and therapeutic aspects of peripheral neuropathies in the setting of malignancies, with the exception of paraproteinemic neuropathies. Our search extended to the past 2 years, using a PubMed search strategy. In the field of neuropathies linked with ... | 18,769,246 |
SWiFT: a rapid triage tool for vulnerable older adults in disaster situations. | : In 2005, Hurricane Katrina caused extensive damage to parts of Mississippi, Louisiana, and Alabama, causing many people, including vulnerable older adults, to evacuate to safe surroundings. Approximately 23,000 evacuees--many of them 65 years old or older, frail, and lacking family to advocate for their care--arrived... | 18,769,267 |
Simultaneous posterior ischemic optic neuropathy, cerebral border zone infarction, and spinal cord infarction after correction of malignant hypertension. | A 31-year-old woman developed bilateral posterior ischemic optic neuropathy and infarctions of the cerebral arterial border zones and spinal cord after correction of malignant hypertension. Although a few reports have described patients with neurologic abnormalities after treatment of malignant hypertension, full clini... | 18,769,283 |
Loss of myelinated retinal nerve fibers from chronic papilledema. | An intracranial pilocytic astrocytoma was diagnosed in a 13-year-old boy after he presented with headaches and visual disturbances. The initial ophthalmoscopic examination revealed papilledema bilaterally and myelinated retinal nerve fibers (MRNFs) in the left eye. Serial ophthalmoscopic examinations demonstrated gradu... | 18,769,289 |
Avoiding "too little, too late" in supporting faculty research. | Many new nursing leaders assuming deanships or assistant or interim deanships have limited education, experience, or background to prepare them for the job. To assist new deans and those aspiring to be deans, the authors of this department, 2 deans, offer survival tips based on their personal experiences and insights. ... | 18,769,314 |
Increased survival and reduced renal injury in MRL/lpr mice treated with a novel sphingosine-1-phosphate receptor agonist. | Agonists of the type 1 sphingosine-1-phosphate (S1P) receptor inhibit lymphocyte migration, causing their sequestration in lymphoid tissue. The S1P agonist FTY720 prolongs the survival of organ allografts and blocks T-cell mediated autoimmune diseases in experimental models; however, it is a non-selective agonist of fo... | 18,769,369 |
New imaging approaches for understanding lung cancer response to treatment. | The survival rate for lung cancer patients has barely improved over the past 30 years. New evaluation benchmarks for cancer response are needed to test therapy agents in a cost-effective and timely manner. From recent work, it is evident that primary lung cancers are very complex structures containing not only cancerou... | 18,769,370 |
Event-horizon-scale structure in the supermassive black hole candidate at the Galactic Centre. | The cores of most galaxies are thought to harbour supermassive black holes, which power galactic nuclei by converting the gravitational energy of accreting matter into radiation. Sagittarius A* (Sgr A*), the compact source of radio, infrared and X-ray emission at the centre of the Milky Way, is the closest example of t... | 18,769,434 |
Multimodal warning signals for a multiple predator world. | Aposematism is an anti-predator defence, dependent on a predator's ability to associate unprofitable prey with a prey-borne signal. Multimodal signals should vary in efficacy according to the sensory systems of different predators; however, until now, the impact of multiple predator classes on the evolution of these si... | 18,769,439 |
SOCS2: inhibitor of JAK2V617F-mediated signal transduction. | Janus kinase 2 (JAK2)V617F-activating mutations (JAK2mu) occur in myeloproliferative disorders (MPDs) and myelodysplastic syndromes (MDSs). Cell lines MB-02, MUTZ-8, SET-2 and UKE-1 carry JAK2V617F and derive from patients with MPD/MDS histories. Challenging the consensus that expression of JAK2V617F is the sole precon... | 18,769,447 |
Directly observed therapy and improved tuberculosis treatment outcomes in Thailand. | The World Health Organization (WHO) recommends that tuberculosis (TB) patients receive directly observed therapy (DOT). Randomized controlled trials have not consistently shown that this practice improves TB treatment success rates. In Thailand, one of 22 WHO-designated high burden TB countries, patients may have TB tr... | 18,769,479 |
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