title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Multiple kinesin motors coordinate cytoplasmic RNA transport on a subpopulation of microtubules in Xenopus oocytes. | RNA localization is a widely conserved mechanism for generating cellular asymmetry. In Xenopus oocytes, microtubule-dependent transport of RNAs to the vegetal cortex underlies germ layer patterning. Although kinesin motors have been implicated in this process, the apparent polarity of the microtubule cytoskeleton has p... | 18,771,961 |
First-trimester serum levels of soluble endoglin and soluble fms-like tyrosine kinase-1 as first-trimester markers for late-onset preeclampsia. | The aim of this investigation was to assess soluble endoglin (sEng) and soluble fms-like tyrosine kinase-1 (sFlt1) as first-trimester serum markers to predict preeclampsia. First-trimester sera were obtained from 46 women with subsequent late-onset preeclampsia and from 92 controls. sEng and sFlt1 concentrations were d... | 18,771,978 |
Obstetric management of hepatitis C-positive mothers: analysis of vertical transmission in 559 mother-infant pairs. | The objective of the study was to determine vertical transmission rates of hepatitis C in 2 tertiary level maternity units. This was a retrospective review of all hepatitis C-positive mothers and their pregnancy outcomes. Of 74,629 deliveries, 559 liveborn infants were born to 545 hepatitis C mothers; the rate of anten... | 18,771,997 |
Dynamics of the dopaminergic system as a key component to the understanding of depression. | For decades, clinical treatment of depression has usually involved antidepressants that target noradrenergic and serotonergic neurotransmission. Over the past half century, no genuinely ground-breaking progress has been made in the pharmacological development of antidepressant drugs. Dopaminergic mesolimbic and mesocor... | 18,772,037 |
Prospects for serotonin 5-HT2R pharmacotherapy in psychostimulant abuse. | The serotonin (5-HT) neurotransmitter system provides fundamental modulatory regulation of the limbic-corticostriatal circuitry known to be vital in the development of addiction as well as the aspects of addiction that hinder recovery and contribute to relapse. Thus, components of the 5-HT system may provide novel targ... | 18,772,040 |
Pharmacological inhibition of dopamine and serotonin activity blocks spontaneous and cocaine-activated behaviour. | The dopaminergic (DA) and serotonergic (5-HT) systems are modulatory transmitter systems that can influence a wide range of behavioural functions. Psychostimulant drugs increase both DA and 5-HT activity by substance-specific mechanisms and, consequently, can broadly influence behavioural and emotional processes in hum... | 18,772,041 |
Serotonergic and dopaminergic modulation of attentional processes. | Disturbances in attentional processes are a common feature of several psychiatric disorders such as schizophrenia, attention deficit/hyperactivity disorder and Huntington's disease. The use of animal models has been useful in defining various candidate neural systems thus enabling us to translate basic laboratory scien... | 18,772,049 |
Baseline low-density lipoprotein cholesterol is an important predictor of the benefit of intensive lipid-lowering therapy: a PROVE IT-TIMI 22 (Pravastatin or Atorvastatin Evaluation and Infection Therapy-Thrombolysis In Myocardial Infarction 22) analysis. | This study sought to determine whether the benefit of intensive lipid-lowering therapy (LLT) is dependent on baseline low-density lipoprotein cholesterol (LDL-C). Aggressive LDL-C reduction with statins improves cardiovascular outcomes in acute and chronic coronary heart disease (CHD). The importance of baseline LDL-C ... | 18,772,061 |
Evidence for involvement of calcitonin gene-related peptide in nitroglycerin response and association with mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys polymorphism. | This study sought to determine whether calcitonin gene-related peptide (CGRP) is involved in glyceryl trinitrate (GTN) response in humans, and its association with mitochondrial aldehyde dehydrogenase-2 (ALDH2) Glu504Lys (ALDH2*2) polymorphism. In animal models, CGRP contributes to the cardiovascular effects of GTN. Th... | 18,772,068 |
Ginsenosides chemistry, biosynthesis, analysis, and potential health effects. | Ginsenosides are a special group of triterpenoid saponins that can be classified into two groups by the skeleton of their aglycones, namely dammarane- and oleanane-type. Ginsenosides are found nearly exclusively in Panax species (ginseng) and up to now more than 150 naturally occurring ginsenosides have been isolated f... | 18,772,102 |
Mature solid teratoma of the fallopian tube associated with uterine leiomyomas. | Benign solid teratomas within the fallopian tube are rare. The incidence of this kind of benign solid teratoma of the fallopian tube associated with intrauterine leiomyomas is extremely low and may complicate the clinical manifestations. Here, we report a 40-year-old female with periodic lower abdominal pain and hyperm... | 18,772,124 |
High-output heart failure resulting from an obscure traumatic arteriovenous fistula. | Traumatic arteriovenous fistula (AVF) is not an uncommon disorder, but late discovery and the presentation of high-output heart failure is very rare. This patient did not know that he had traumatic AVF after a gunshot injury in the left thigh 14 years ago. The major presentation of the AVF was signs of heart failure. W... | 18,772,125 |
Lysophospholipid acyltransferases and arachidonate recycling in human neutrophils. | The cycle of deacylation and reacylation of phospholipids plays a critical role in regulating availability of arachidonic acid for eicosanoid production. The major yeast lysophospholipid acyltransferase, Ale1p, is related to mammalian membrane-bound O-acyltransferase (MBOAT) proteins. We expressed four human MBOATs in ... | 18,772,128 |
TRAF6 specifically contributes to FcepsilonRI-mediated cytokine production but not mast cell degranulation. | TRAF6 (tumor necrosis factor-associated factor 6) is an essential adaptor downstream from the tumor necrosis factor (TNF) receptor and Toll-like receptor superfamily members. This molecule is critical for dendritic cell maturation and T cell homeostasis. Here we show that TRAF6 is important in high affinity IgE recepto... | 18,772,140 |
Disease-causing mutation in GPR54 reveals the importance of the second intracellular loop for class A G-protein-coupled receptor function. | The G-protein-coupled receptor (GPCR) GPR54 is essential for the development and maintenance of reproductive function in mammals. A point mutation (L148S) in the second intracellular loop (IL2) of GPR54 causes idiopathic hypogonadotropic hypogonadism, a disorder characterized by delayed puberty and infertility. Here, w... | 18,772,143 |
FACTA: a text search engine for finding associated biomedical concepts. | FACTA is a text search engine for MEDLINE abstracts, which is designed particularly to help users browse biomedical concepts (e.g. genes/proteins, diseases, enzymes and chemical compounds) appearing in the documents retrieved by the query. The concepts are presented to the user in a tabular format and ranked based on t... | 18,772,154 |
Isolation of small RNAs using biotinylated PNAs. | In this study, an RNA isolation method was developed using a biotinylated peptide nucleic acid (PNA) that is complementary to the target RNA. Using the biotinylated PNA method, we successfully isolated several RNAs from Escherichia coli and from human total RNA in pure form. Damage to the RNA appears to be negligible b... | 18,772,156 |
First occurrence of KPC-2-possessing Klebsiella pneumoniae in a Greek hospital and recommendation for detection with boronic acid disc tests. | To investigate the first KPC carbapenemase-producing Klebsiella pneumoniae isolate from a Greek hospital, including phenotypic methods to aid recognition of this resistance type. A carbapenem-resistant clinical isolate of K. pneumoniae was recovered from a hospitalized Greek patient. Detailed susceptibility testing was... | 18,772,158 |
Minilaparotomy radical cystoprostatectomy (Minilap RCP) in the surgical management of urinary bladder carcinoma: early experience. | To assess the feasibility of minilaparotomy for radical cystoprostatectomy (RCP) and urinary diversion in the management of urinary bladder carcinoma. A total of 45 consecutive patients with muscle invasive urinary bladder cancer underwent RCP and urinary diversion [32, 12 and 1 patients with pitchers pot orthotopic ne... | 18,772,171 |
Comparison of inflammatory markers and angiographic outcomes after implantation of sirolimus and paclitaxel-eluting stents. | We compared the degree of systemic inflammation and its relation to the angiographic outcomes after drug-eluting stent (DES) implantations. We implanted a single DES in 79 stable angina patients (50 men; 60.4 (9.5) years of age; sirolimus-eluting stent (SES), n = 38; paclitaxel-eluting stent (PES), n = 41). The high-se... | 18,772,180 |
Differential origin of reticulospinal drive to motoneurons innervating trunk and hindlimb muscles in the mouse revealed by optical recording. | To better understand how the brainstem reticular formation controls and coordinates trunk and hindlimb muscle activity, we used optical recording to characterize the functional connections between medullary reticulospinal neurons and lumbar motoneurons of the L2 segment in the neonatal mouse. In an isolated brainstem-s... | 18,772,205 |
Tonic activation of group I mGluRs modulates inhibitory synaptic strength by regulating KCC2 activity. | The furosemide-sensitive potassium-chloride cotransporter (KCC2) plays an important role in establishing the intracellular chloride concentration in many neurons within the central nervous system. Consequently, modulation of KCC2 function will regulate the reversal potential for synaptic GABAergic inputs, thus setting ... | 18,772,206 |
Kinetics and thermodynamics of salt-dependent T7 gene 2.5 protein binding to single- and double-stranded DNA. | Bacteriophage T7 gene 2.5 protein (gp2.5) is a single-stranded DNA (ssDNA)-binding protein that has essential roles in DNA replication, recombination and repair. However, it differs from other ssDNA-binding proteins by its weaker binding to ssDNA and lack of cooperative ssDNA binding. By studying the rate-dependent DNA... | 18,772,224 |
Progesterone influence on neurite outgrowth involves microglia. | Progesterone (P4) antagonizes estradiol (E2) in synaptic remodeling in the hippocampus during the rat estrous cycle. To further understand how P4 modulates synaptic plasticity, we used entorhinal cortex lesions, which induce E2-dependent neurite sprouting in the hippocampus. In young ovariectomized rats, the E2-depende... | 18,772,232 |
Diet or exercise: what is more effective in preventing or reducing metabolic alterations? | The influence of diet and exercise on metabolic syndrome is controversial since fit individuals might also eat healthier foods. We evaluated the association of diet/exercise variation with reductions in metabolic variables and C-reactive protein (CRP) values in the experimental and control arms of a 1-year randomized l... | 18,772,269 |
Depression in patients with diabetes: does it impact clinical goals? | To examine whether depressive symptoms are associated with achievement of recommended goals for control of glucose, lipids, and blood pressure among patients with diabetes. We used a prospective cohort study of 1223 adults with diabetes that obtained self-reported depression symptoms from a survey. Medication use was o... | 18,772,293 |
Do guidelines for the diagnosis and monitoring of diabetes mellitus fulfill the criteria of evidence-based guideline development? | Although the methodological quality of therapeutic guidelines (GLs) has been criticized, little is known regarding the quality of GLs that make diagnostic recommendations. Therefore, we assessed the methodological quality of GLs providing diagnostic recommendations for managing diabetes mellitus (DM) and explored sever... | 18,772,309 |
IFATS collection: Fibroblast growth factor-2-induced hepatocyte growth factor secretion by adipose-derived stromal cells inhibits postinjury fibrogenesis through a c-Jun N-terminal kinase-dependent mechanism. | Adipose-derived stem/stromal cells (ASCs) not only function as tissue-specific progenitor cells but also are multipotent and secrete angiogenic growth factors, such as hepatocyte growth factor (HGF), under certain circumstances. However, the biological role and regulatory mechanism of this secretion have not been well ... | 18,772,314 |
Nanomolar concentrations of pregnenolone sulfate enhance striatal dopamine overflow in vivo. | The balance between GABA-mediated inhibitory and glutamate-mediated excitatory synaptic transmission represents a fundamental mechanism for controlling nervous system function, and modulators that can alter this balance may participate in the pathophysiology of neuropsychiatric disorders. Pregnenolone sulfate (PS) is a... | 18,772,319 |
Hypoglossal premotor neurons of the intermediate medullary reticular region express cholinergic markers. | The inspiratory drive to hypoglossal (XII) motoneurons originates in the caudal medullary intermediate reticular (IRt) region. This drive is mainly glutamatergic, but little is known about the neurochemical features of IRt XII premotor neurons. Prompted by the evidence that XII motoneuronal activity is controlled by bo... | 18,772,326 |
The role of p66Shc deletion in age-associated arterial dysfunction and disease states. | Accumulation of oxidative stress with age is hypothesized to be the primary causative mediator of age-associated diseases. Among different tissues, aging vessels are known to accumulate oxidative damage and undergo functional impairment. Oxidative stress affects the availability and/or balance of key regulators of vasc... | 18,772,327 |
Endothelial dysfunction caused by circulating microparticles from patients with metabolic syndrome. | Microparticles are membrane vesicles that are released during cell activation and apoptosis. Elevated levels of microparticles occur in many cardiovascular diseases; therefore, we characterized circulating microparticles from both metabolic syndrome (MS) patients and healthy patients. We evaluated microparticle effects... | 18,772,329 |
Prevention of hepatic fibrosis in a murine model of metabolic syndrome with nonalcoholic steatohepatitis. | The endocannabinoid pathway plays an important role in the regulation of appetite and body weight, hepatic lipid metabolism, and fibrosis. Blockade of the endocannabinoid receptor CB1 with SR141716 promotes weight loss, reduces hepatocyte fatty acid synthesis, and is antifibrotic. D-4F, an apolipoprotein A-1 mimetic wi... | 18,772,330 |
Smad-independent transforming growth factor-beta regulation of early growth response-1 and sustained expression in fibrosis: implications for scleroderma. | Transforming growth factor-beta (TGF-beta) plays a key role in scleroderma pathogenesis. The transcription factor early growth response-1 (Egr-1) mediates the stimulation of collagen transcription elicited by TGF-beta and is necessary for the development of pulmonary fibrosis in mice. Here, we report that TGF-beta caus... | 18,772,333 |
The endothelin-converting enzyme-1/endothelin-1 pathway plays a critical role in inflammation-associated premature delivery in a mouse model. | Premature delivery occurs in 12% of all births and accounts for nearly half of long-term morbidity. Current therapeutic approaches to preterm delivery are ineffective and present serious risks to both mother and fetus. The single most common cause of preterm birth is infection. Previous in vitro investigations have sho... | 18,772,340 |
An unusual cause of atrial tachycardia in a young patient with lymphoma. | An 8-year-old girl who was recently diagnosed as having anaplastic large-cell lymphoma presented with atrial tachycardia and dilated cardiomyopathy, which is a contraindication for further treatment with cardio-toxic chemotherapy. After starting digoxin therapy, the dilated cardiomyopathy resolved. Repeated episodes of... | 18,772,357 |
Crosspresentation by nonhematopoietic and direct presentation by hematopoietic cells induce central tolerance to myelin basic protein. | Central tolerance plays a critical role in eliminating self-reactive T cells specific for peripheral antigens. Here we show that central tolerance of MHC class I-restricted T cells specific for classic myelin basic protein (MBP), a component of the myelin sheath, is mediated by both bone marrow (BM)-derived and nonBM-d... | 18,772,374 |
A transcript profiling approach reveals an epicatechin-specific glucosyltransferase expressed in the seed coat of Medicago truncatula. | Expression of the Arabidopsis TRANSPARENT TESTA 2 (TT2) MYB family transcription factor leads to massive accumulation of proanthocyanidins (PAs) in hairy roots of Medicago truncatula. Microarray analysis showed that TT2 induces genes for flavonoid/PA biosynthesis, transcription factors, and a large number of genes of u... | 18,772,380 |
Comment on "Fire-derived charcoal causes loss of forest humus". | Wardle et al. (Brevia, 2 May 2008, p. 629) reported that fire-derived charcoal can promote loss of forest humus and belowground carbon (C). However, C loss from charcoal-humus mixtures can be explained not only by accelerated loss of humus but also by loss of charcoal. It is also unclear whether such loss is related to... | 18,772,418 |
Microcatheter contrast injections during intra-arterial thrombolysis may increase intracranial hemorrhage risk. | During intra-arterial revascularization, either guide catheter injections of contrast in the neck or microcatheter contrast injections (MCIs) at or beyond the site of an occlusion, can be used to visualize intracranial vasculature. Neurointerventionalists vary widely in their use of MCIs for a given circumstance. We te... | 18,772,441 |
Association of longer telomeres with better health in centenarians. | Prior animal model studies have demonstrated an association between telomere length and longevity. Our study examines telomere length in centenarians in good health versus poor health. Using DNA from blood lymphocytes, telomere length was measured by quantitative polymerase chain reaction in 38 sex- and age-matched cen... | 18,772,468 |
Trafficking pathways of mycolic acids: structures, origin, mechanism of formation, and storage form of mycobacteric acids. | Mycolic acids, the hallmark of mycobacteria and related bacteria, are major and specific components of their cell envelope and essential for the mycobacterial survival. Mycobacteria contain structurally related long-chain lipids, but the metabolic relationships between these various classes of compounds remain obscure.... | 18,772,482 |
[Expression and SNP analysis of BRD7 gene in acute leukemia cells]. | To evaluate the expression level of BRD7 gene in bone marrow mononuclear cells (BMNCs) in patients with acute leukemia (AL) and to analyze BRD7 single nucleotide polymorphism(SNP). RT-PCR was used to detect BRD7 expression in patients with AL and normal bone marrow subjects. Single-strand conformation polymorphism and ... | 18,772,500 |
Molecular mechanisms underlying the transition of cardiac hypertrophy to heart failure. | Heart failure is a condition in which the heart cannot supply enough blood to the body's organs, and is a final common consequence of various heart diseases. In the past 2 decades, much progress has been made in understanding the molecular and cellular processes that contribute to cardiac hypertrophy and heart failure,... | 18,772,527 |
[A case report of ball valve syndrome caused by the gastrointestinal stromal tumor arising from the muscularis mucosae in gastric fornix]. | An 83-year-old woman who was admitted to other hospital, was consulted us because of continuous tarry stool and abdominal fullness. On upper endoscopy, the submucosal tumor from greater curvature of gastric fornix invaginated into the duodenal bulbus, showing so-called "ball valve syndrome (BVS)". As the tumor incarcer... | 18,772,574 |
Effects of gender, gonadectomy and sex hormones on growth and plasma cholesterol level in rats. | No studies have clearly demonstrated how sex hormones are involved in the observed gender difference in growth and plasma cholesterol levels in animals fed hypercholesterolemic diets. This study was conducted to determine the effects of gender, gonadectomy (GNX), and sex hormones on growth, plasma cholesterol and corti... | 18,772,583 |
Methotrexate-loaded polymethylmethacrylate bone cement for local bone metastasis therapy: pilot animal study in the rabbit patellar groove. | Local chemotherapy is an option in bone metastasis treatment. On the other hand, evaluation of side effects on bone is a difficult issue in drug development and biomaterials research. Most animal models to date are inappropriate or not feasible. Rabbits are an alternative to other bigger mammals and have an appropriate... | 18,772,590 |
Angiographic and intravascular ultrasound assessment of immediate and 9-month efficacy of percutaneous transluminal renal artery balloon angioplasty with subsequent brachytherapy in patients with renovascular hypertension. | Scarce data exist concerning the long-term effect of renal balloon angioplasty (PTRA) enhanced by intravascular gamma-brachytherapy (IVBT) in patients with renovascular hypertension. The aim of this randomized study was to evaluate long-term outcome after PTRA with IVBT in patients with renal artery stenosis. 71 patien... | 18,772,602 |
Growth hormone stimulates mechano growth factor expression and activates myoblast transformation in C2C12 cells. | Mechano growth factor (MGF) is an alternatively spliced variant of insulin-like growth factor-I (IGF-I). Previous reports have revealed that the MGF in skeletal muscles is induced by mechanical overload or muscle injury. In the present study, we examined the effect of growth hormone (GH) on MGF expression in C2C12 mous... | 18,772,608 |
The efficacy of reboxetine as an antidepressant, a meta-analysis of both continuous (mean HAM-D score) and dichotomous (response rate) outcomes. | Reboxetine is the first selective Norepinephrine Reuptake Inhibitor (NRI). There are limited numbers of quantitative synthesis studies of the efficacy of this drug in treating depressive disorders. We have meta-analyzed the efficacy of the reboxetine using both continuous and dichotomous outcome measures. Data was coll... | 18,772,616 |
Predictive value of admission electrocardiography in patients with heart failure. | Admission electrocardiography (ECG) in heart failure (HF) patients provides important diagnostic information; however, there are limited data regarding the prognostic significance of ECG parameters for predicting cardiac events (CEs). The ECGs of 246 patients admitted with acute HF were evaluated for heart rate, rhythm... | 18,772,621 |
Thermal therapy: a viable adjunct in the treatment of heart failure? | The aim of this work was to review and provide a summary of published literature on the clinical impact of thermal therapy (ie, warm water immersion, traditional sauna bathing, and dry infrared sauna) in patients with heart failure. Medline and Embase database literature searches were conducted, and studies that includ... | 18,772,622 |
Characteristics, drug therapy, and outcomes from a database of 500,000 hospitalized patients with a discharge diagnosis of heart failure. | Knowledge related to acute heart failure (HF) and its management in "real-world" clinical practice is limited. The authors delineated characteristics and drug therapy for hospitalized HF patients and their association with clinical and economic outcomes. The NDCHealth (National Data Corporation, Atlanta, GA) database, ... | 18,772,626 |
Blood pressure control in patients with comorbidities. | Hypertension frequently coexists with obesity, diabetes, hyperlipidemia, or the metabolic syndrome; their association with cardiovascular disease is well established. The identification and management of these risk factors is an important part of the overall management of hypertensive patients. Because patients in thes... | 18,772,645 |
Receiving bad news: a phenomenological exploration of the lived experience of receiving a cancer diagnosis. | This article explores the process of coming to a place of knowing one's diagnosis of cancer. The study was guided by the philosophy of hermeneutic phenomenology, with data collected via unstructured in-depth interviews. This article focuses on 10 people who received a cancer diagnosis (recipients). The analysis of the ... | 18,772,654 |
Implications of systematic review for breast cancer prediction. | Highly accurate and predictive models are essential components to promote early breast cancer screening in primary care or home care settings. This study was conducted to demonstrate how the relevant variable selection process influenced the predictive performance of the model to identify individuals at high risk for b... | 18,772,655 |
Enhancing hope among early female survivors of childhood cancer via the internet: a feasibility study. | The purpose of this research was to establish the feasibility of delivering the Hope Intervention Program (HIP) using a Web-based design among 6 female survivors of childhood cancer. The HIP is an 8-week program to foster and promote hope. Each session of the HIP has specific focus, goals, and activities that offer opp... | 18,772,662 |
Pediatric strabismus imaging. | With both radiologists and ophthalmologists in mind, this article describes the best use of computed tomography and magnetic resonance imaging in the diagnosis of strabismus. Both computed tomography and magnetic resonance imaging are valuable tools in evaluation of strabismus, despite concerns about radiation exposure... | 18,772,668 |
Psychosocial characteristics of cancer patients who choose to attend an educational session on cancer-related fatigue. | Little is known about cancer patients who seek specific educational interventions on cancer-related fatigue (CRF). The objectives of this study were (1) to describe the level of CRF, and emotional distress; social support; coping styles; and quality of life of patients who chose to attend a 1-hour educational session o... | 18,772,666 |
Targeted monoclonal antibody therapy and radioimmunotherapy for lymphoproliferative disorders of the ocular adnexa. | The goal of this review is to update ophthalmologists and orbital and adnexal specialists with the emerging role of targeted monoclonal antibody therapy and radioimmunotherapy for orbital and adnexal non-Hodgkin's lymphoma and other lymphoproliferative disorders of the orbit. Rituximab as monotherapy for indolent lymph... | 18,772,675 |
Ptosis repair options and algorithm. | The treatment options for ptosis are strictly surgical. Each patient needs to be individually assessed and treated. A surgeon needs to be familiar with all types of surgical repair to choose the best possible option for his/her particular patient. There are certain established surgeries in ptosis repair; however, there... | 18,772,677 |
Response to oral supplementation in copper deficiency myeloneuropathy. | Neurological manifestations due to copper deficiency include ataxic myeloneuropathy that resembles subacute combined degeneration due to B12 deficiency. We report our experience in the treatment of 10 patients with copper deficiency myeloneuropathy and conclude that copper supplementation leads to stabilization rather ... | 18,772,693 |
Low bone mineral density in spinal muscular atrophy. | Pathological fractures are common in pediatric neuromuscular disorders. Dual-energy x-ray absorptiometry has become the most accepted technique for the measurement of bone mineral density (BMD) in adults and children. Limited data are available on BMD in pediatric neuromuscular diseases except Duchenne muscular dystrop... | 18,772,695 |
Bifrontal versus bitemporal electroconvulsive therapy in severe manic patients. | To compare the efficacy and safety of moderate-dose bifrontal (BF) with low-dose bitemporal (BT) electroconvulsive therapy (ECT) in the treatment of patients with severe mania. In a parallel, double-blind, randomized clinical trial, 28 patients with severe mania admitted to a university hospital were assigned randomly ... | 18,772,704 |
[Peri-partum hemorrhage: surgical management]. | Surgeons must be aware of the surgical techniques necessary to control grave peri-partum hemorrhage which place the life of the mother in jeopardy; at times, surgery is the only life-saving solution in spite of all the medical, obstetrical, and interventional radiologic techniques which have been developed. Surgical in... | 18,772,729 |
[Impact of the French consensus guidelines on the management of colonic and rectal cancer: a population-based study]. | To compare the management of colorectal cancer (CRC) before and after the French consensus conferences of rectal cancer (RC) in 1994 and colonic cancer (CC) in 1998. From 344 CCR incident cases in 1992 and 545 in 2000, patient characteristics, tumor data, and diagnostic and treatment modalities were collected to compar... | 18,772,733 |
[Cervical lymph nodes]. | Imaging plays a chief role in the care and monitoring of patients in cervico-facial oncology. The radiologist must know the anatomy of different lymph nodes as well as signs of malignancy (hypertrophy, enhancement, necrosis, capsular rupture, etc.). CT is still the first-line examination because of its high reliability... | 18,772,779 |
[Stab injury to the cervical cord: report of three cases]. | Retrospective review of the value of MR in the evaluation of stab injuries to the cervical cord in three patients admitted to our hospital. The mean patient age was 25 years old. Clinical examination showed hemiparesis in the first 2 cases and a Brown-Sequard syndrome in the third patient. Cervical spine radiographs sh... | 18,772,788 |
[Cataract surgery and age-related maculopathy: benefits in terms of visual acuity and quality of life--a prospective study]. | To assess the benefits of cataract surgery in patients with age-related macular degeneration (AMD) in terms of visual acuity and quality of life. Forty-two eyes of 30 patients were included in this prospective study between October 2003 and January 2005. The eyes were divided into two groups: the first group (n=12) wit... | 18,772,807 |
[Polypoidal choroidal vasculopathy: clinical and angiographic features]. | To clarify the clinical and angiographic characteristics of idiopathic polypoidal choroidal vasculopathy (IPCV) and its natural course. Descriptive, prospective, consecutive case series of patients with presumed IPCV seen at Fort-de-France Hospital Center (French West Indies) between January and June 2006. All particip... | 18,772,808 |
[Folic acid in physiology and pathology]. | This paper presents current knowledge of the biological functions of folic acid, the effects of its deficiency in the organism, as well as the possibilities of its therapeutic use. Folic acid (folate, B9) is a vitamin of special importance in normal cellular functions. Tetrahydrofolate (TH4-folate) is the biologically ... | 18,772,846 |
[The role of matrix metalloproteinases in the pathogenesis of diabetes mellitus and progression of diabetes retinopathy]. | Matrix metalloproteinases (MMPs) comprise a family of over 20 structurally related proteins which are zinc-dependent and calcium-activated endopeptidases. The members of this family are able to degrade most extracellular matrix (ECM) proteins and are thus involved in tissue remodeling and contribute to cell migration b... | 18,772,849 |
PCR-based gene targeting in Candida albicans. | PCR-based gene-targeting approaches have increased the speed of gene function analyses in ascomycetous fungi, for example, in the diploid human fungal pathogen Candida albicans. Here we describe a protocol that utilizes Rapid-PCR to amplify all cassettes available with the previously reported pFA modules. With this pro... | 18,772,868 |
Neutral desorption sampling of biological surfaces for rapid chemical characterization by extractive electrospray ionization mass spectrometry. | Extractive electrospray ionization mass spectrometry (EESI-MS) allows the real-time, direct analysis of complex gaseous and liquid samples without any sample pretreatment under ambient conditions. By using a neutral desorption (ND) sampling gas beam to gently impact a surface, the analyte present on a surface can be ef... | 18,772,874 |
Cripto recruits Furin and PACE4 and controls Nodal trafficking during proteolytic maturation. | The glycosylphosphatidylinositol (GPI)-anchored proteoglycan Cripto binds Nodal and its type I receptor Alk4 to activate Smad2,3 transcription factors, but a role during Nodal precursor processing has not been described. We show that Cripto also binds the proprotein convertases Furin and PACE4 and localizes Nodal proce... | 18,772,886 |
Graphene 2.0. | Once the preserve of physicists, graphene is now attracting the attention of growing numbers of chemists, who are discovering new ways to produce this remarkable material. | 18,772,903 |
Enhanced combined tumor-specific oncolysis and suicide gene therapy for prostate cancer using M6 promoter. | Enzyme pro-drug suicide gene therapy has been hindered by inefficient viral delivery and gene transduction. To further explore the potential of this approach, we have developed AdIU1, a prostate-restricted replicative adenovirus (PRRA) armed with the herpes simplex virus thymidine kinase (HSV-TK). In our previous Ad-OC... | 18,772,902 |
An atomic-resolution nanomechanical mass sensor. | Mechanical resonators are widely used as inertial balances to detect small quantities of adsorbed mass through shifts in oscillation frequency. Advances in lithography and materials synthesis have enabled the fabrication of nanoscale mechanical resonators, which have been operated as precision force, position and mass ... | 18,772,913 |
Highly conducting graphene sheets and Langmuir-Blodgett films. | Graphene is an intriguing material with properties that are distinct from those of other graphitic systems. The first samples of pristine graphene were obtained by 'peeling off' and epitaxial growth. Recently, the chemical reduction of graphite oxide was used to produce covalently functionalized single-layer graphene o... | 18,772,914 |
Revival of saprotrophic and mycorrhizal basidiomycete cultures after 20 years in cold storage in sterile water. | Vegetatively colonized agar cores of 69 basidiomycete fungus isolates (48 species in 30 genera and 17 families) were stored at 5 degrees C in tubes of sterile distilled water without manipulation for 20 years. These were represented by 34 isolates of saprotrophic fungi (29 species in 19 genera) and 35 isolates of mycor... | 18,772,921 |
Differences in nitric oxide steady states between arginine, hypoxanthine, uracil auxotrophs (AHU) and non-AHU strains of Neisseria gonorrhoeae during anaerobic respiration in the presence of nitrite. | Neisseria gonorrhoeae can grow by anaerobic respiration using nitrite as an alternative electron acceptor. Under these growth conditions, N. gonorrhoeae produces and degrades nitric oxide (NO), an important host defense molecule. Laboratory strain F62 has been shown to establish and maintain a NO steady-state level tha... | 18,772,926 |
Use of the 16S-23S ribosomal genes spacer region for the molecular typing of sphingomonads. | The ability of sphingomonads in drinking water to cause community- and hospital-acquired opportunistic infections has raised the need to establish reproducible identification assays. In this study, a total of 129 isolates recovered from drinking water with yellow- to orange-pigmented colonies were distributed among 10 ... | 18,772,929 |
The Pic19 NBS-LRR gene family members are closely linked to Scmv1, but not involved in maize resistance to sugarcane mosaic virus. | Sugarcane mosaic virus (SCMV) is the causal pathogen for a severe mosaic virus disease of maize worldwide. In our previous research, the maize resistance gene analog (RGA) Pic19 and its three cognate BAC contigs were mapped to the same region as the SCMV resistance gene Scmv1. Here we report the isolation and character... | 18,772,945 |
Effect of nano-scale crystal field on the broadening of Er3+- emission in sodium tellurite glass ceramics. | In this paper we report the effect of heat treatment of 10 mol% Na(2)O-89.5 mol% TeO(2) glass for studying the fluorescence and line broadening behavior of Er-ions in the glass-ceramic matrix. Controlled crystal growth measurements using the X-ray line broadening technique for samples heat treated in the temperature ra... | 18,772,961 |
Low loss elliptical core D-fiber to PANDA fiber fusion splicing. | Elliptical core D-fiber is difficult to fusion splice to other types of fiber due to its small core and D-shaped cladding. The presented method of splicing D-fiber to PANDA fiber involves using E-fiber in a bridge splice. The E-fiber core is expanded to match the mode of the PANDA fiber. The D-fiber is then connected t... | 18,772,964 |
Successive order, multiple scattering of two-term Henyey-Greenstein phase functions. | An analytic solution to the problem of determining photon direction after successive scatterings in an infinite, homogeneous, isotropic medium, where each scattering event is in accordance with a two-term Henyey-Greenstein phase function, is presented and compared against Monte Carlo simulation results. The photon dire... | 18,772,974 |
Fast time-domain diffuse optical tomography using pseudorandom bit sequences. | We report a novel time-domain diffuse optical tomography to determine the optical properties in a faster speed than the conventional ones. Instead of using the ultrashort pulse laser, a 2.5 Gbps pseudorandom bit sequence is used to modulate the near-infrared light for tissue-like phantom illumination. The time-resolved... | 18,772,975 |
Measuring the spatiotemporal electric field of tightly focused ultrashort pulses with sub-micron spatial resolution. | We demonstrate a powerful and practical spectral interferometer with near-field scanning microscopy (NSOM) probes for measuring the spatiotemporal electric field of tightly focused ultrashort pulses with high spatial and spectral resolution. Our measurements involved numerical apertures as high as 0.44 and yielded the ... | 18,772,978 |
A photon-counting time-of-flight ranging technique developed for the avoidance of range ambiguity at gigahertz clock rates. | This paper describes a rapid data acquisition photon-counting time-of-flight ranging technique that is designed for the avoidance of range ambiguity, an issue commonly found in high repetition frequency time-off-light systems. The technique transmits a non-periodic pulse train based on the random bin filling of a high ... | 18,772,980 |
Reconstructing subsurface electrical wave orientation from cardiac epi-fluorescence recordings: Monte Carlo versus diffusion approximation. | The development of voltage-sensitive dyes has revolutionized cardiac electrophysiology and made optical imaging of cardiac electrical activity possible. Photon diffusion models coupled to electrical excitation models have been successful in qualitatively predicting the shape of the optical action potential and its depe... | 18,772,987 |
Two-photon induced polymer nanomovement. | We present the first report of two-photon induced plastic surface deformation in solid polymer films. Exposure of azo polymer films, which absorb in the visible range (lambda(max) = 480 nm), to intense 920 nm irradiation leads to polarization dependent photofluidic polymer nanomovement caused by photoselective two-phot... | 18,773,020 |
Guidelines for palliative surgery of cholangiocarcinoma. | The aims of the guidelines are to help assess the evidence for palliation surgery in patients with cholangiocarcinoma (CCA). The guidelines are classified in accordance with the location of the primary lesion, i.e. intrahepatic, hilar, and distal. They are based on comprehensive literature surveys, including results fr... | 18,773,044 |
Surgery for extrahepatic cholangiocarcinoma: predictors of survival. | The incidence of extrahepatic cholangiocarcinoma is increasing worldwide and is often in an advanced stage at diagnosis and difficult to treat. The TNM (tumor node metastasis) cancer staging system predicts survival on the basis of tumor histopathology and the presence of distant metastases. However, numerous prognosti... | 18,773,053 |
Development of a swine model of secondary liver tumor from a genetically induced swine fibroblast cell line. | Metastatic disease is the most common liver tumor. Although alternative therapies have been developed for non-surgical candidates, those therapies lacked ideal testing prior to clinical application because of a paucity of large animal models. The purpose of the present study was to develop a model for secondary liver t... | 18,773,055 |
Staging cholangiocarcinoma by imaging studies. | Cholangiocarcinoma (CCA) is an adenocarcinoma that arises from the bile duct epithelium and is observed in the entire biliary tree (intrahepatic, hilum, and extrahepatic distal). The staging of this tumor differs depending on location. The role of imaging in the staging of hilar CCA is to assess the extent of ductal in... | 18,773,065 |
Identification of neural crest and glial enhancers at the mouse Sox10 locus through transgenesis in zebrafish. | Sox10 is a dynamically regulated transcription factor gene that is essential for the development of neural crest-derived and oligodendroglial populations. Developmental genes often require multiple regulatory sequences that integrate discrete and overlapping functions to coordinate their expression. To identify Sox10 c... | 18,773,071 |
Rhythm generation through period concatenation in rat somatosensory cortex. | Rhythmic voltage oscillations resulting from the summed activity of neuronal populations occur in many nervous systems. Contemporary observations suggest that coexistent oscillations interact and, in time, may switch in dominance. We recently reported an example of these interactions recorded from in vitro preparations... | 18,773,075 |
Toward a comprehensive approach to the collection and analysis of pica substances, with emphasis on geophagic materials. | Pica, the craving and subsequent consumption of non-food substances such as earth, charcoal, and raw starch, has been an enigma for more than 2000 years. Currently, there are little available data for testing major hypotheses about pica because of methodological limitations and lack of attention to the problem. In this... | 18,773,081 |
Stability and dynamics of polycomb target sites in Drosophila development. | Polycomb-group (PcG) and Trithorax-group proteins together form a maintenance machinery that is responsible for stable heritable states of gene activity. While the best-studied target genes are the Hox genes of the Antennapedia and Bithorax complexes, a large number of key developmental genes are also Polycomb (Pc) tar... | 18,773,083 |
Ultrasonically activated device for parenchymal division during open hepatectomy. | The use of new technological devices has gained popularity and has been proposed to improve the safety of liver resection. This study was designed to evaluate the usefulness of the ultrasonically activated device (USAD) during open liver resection. Indication for surgery, type of resection, need to perform a Pringle ma... | 18,773,104 |
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