title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Better environmental decision making - recent progress and future trends. | Recent trends in risk-based decision making are reviewed in relation to novel developments in comparative risk analysis, strategic risk analysis, weight of evidence frameworks, and participative decision making. Delivery of these innovations must take account of organisational capabilities in risk management and the in... | 18,774,589 |
Diffusion-weighted magnetic resonance imaging in the early detection of response to chemoradiation in cervical cancer. | To investigate diffusion-weighted magnetic resonance imaging (DWI) as an early and reproducible response indicator in women receiving concurrent radiotherapy and chemotherapy (chemoradiation) for advanced cervical cancer. Twenty women with advanced cervical cancer were included in a prospective cohort study. DWI was ca... | 18,774,597 |
Effect of bleaching on the elution of monomers from modern dental composite materials. | The aim of this study was to evaluate the effect of bleaching on the elution of monomers from two modern composite materials. Two different resin composites (a nanohybrid the Filtek Supreme XT and an ormocer the Ceram X) were bleached with two products (hydrogen peroxide 38% for 45 min and carbamide peroxide 15% for 56... | 18,774,601 |
Intermediate-scale 2D experimental investigation of in situ chemical oxidation using potassium permanganate for remediation of complex DNAPL source zones. | In situ chemical oxidation is a technology that has been applied to speed up remediation of a contaminant source zone by inducing increased mass transfer from DNAPL sources into the aqueous phase for subsequent destruction. The DNAPL source zone can consist of one or more individual sources that may be present as an in... | 18,774,622 |
The study of operating variables in soil washing with EDTA. | This study discusses the operating variables for removal of metals from soils using EDTA, including the type of EDTA, reaction time, solution pH, dose, temperature, agitation, ultrasound and number of extractions. For As, Cd, Cu, Pb and Zn, the removal efficiency order was: H(4)-EDTA > Na(2)EDTA > (NH(4))(2)EDTA.... | 18,774,633 |
Isolation and characterization of human anti-VEGF165 monoclonal antibody with anti-tumor efficacy from transgenic mice expressing human immunoglobulin loci. | The purpose of this study was to prepare a fully human anti-VEGF (vascular endothelial growth factor) monoclonal antibody with anti-tumor activity from five-feature mice which express human immunoglobin loci. Four hybridomas secreting mAb stably were isolated successfully. Some characters such as isotypes, cross-reacti... | 18,774,636 |
The growth inhibitory effect of lapatinib, a dual inhibitor of EGFR and HER2 tyrosine kinase, in gastric cancer cell lines. | HER2 overexpression is observed in 5-25% of gastric cancers. Lapatinib is a dual inhibitor of the epidermal growth factor receptor and HER2 tyrosine kinase. We examined the antitumor effect of lapatinib in gastric cancer cell lines. Lapatinib induced selective and potent growth inhibition in two HER2-amplified gastric ... | 18,774,637 |
Switch of transforming growth factor beta function from tumor suppression to stimulation in adenomatous polyposis coli (APC) knocked-down human colon carcinoma cells. | TGFbeta exerts a potent tumor-suppressive effect in the human colon carcinoma CBS and Moser cells. However, TGFbeta can also function as a tumor promoter. The mechanisms underlying the tumor promoting effect of TGFbeta are not understood. Both the CBS and Moser cells were found to express mutant (truncated) APC. Expres... | 18,774,639 |
Further study of Codiostomum struthionis (Horst, 1885) Railliet and Henry, 1911 (Nematoda, Strongylidae) parasite of ostriches (Struthio camelus Linnaeus, 1758) (Aves, Struthioniformes). | Codiostomum struthionis is a nematode parasite of the ostrich caecum. Little is known about its pathology, being considered by many authors as a non-pathogenic parasite. Infections by C. struthionis are sometimes overlooked because its eggs are indistinguishable from another ostrich nematode, Libyostrongylus spp. Fecal... | 18,774,651 |
Elevated copper and oxidative stress in cancer cells as a target for cancer treatment. | As we gain a better understanding of the factors affecting cancer etiology, we can design improved treatment strategies. Over the past three to four decades, there have been numerous successful efforts in recognizing important cellular proteins essential in cancer growth and therefore these proteins have been targeted ... | 18,774,652 |
The relation of salivary cortisol to patterns of performance on a word list learning task in healthy older adults. | A pattern of performance on a word list learning task known as a reduced primacy effect has been shown to be characteristic of Alzheimer's disease (AD) and can distinguish AD from depression. Deficits in memory and hippocampal atrophy seen in AD have been associated with hypercortisolism. The present study evaluated wh... | 18,774,653 |
Upgrading the Gleason score in extended prostate biopsy: implications for treatment choice. | To determine the incidence of overestimation of Gleason score (GS) in extended prostate biopsy, and consequently circumventing unnecessary aggressive treatment. This is a retrospective study of 464 patients who underwent prostate biopsy and radical prostatectomy between January 2001 and November 2007. The GS from biops... | 18,774,658 |
Modification of the side chain of micromolide, an anti-tuberculosis natural product. | This paper describes a series of modifications of the side chain of micromolide, an anti-tuberculosis natural product. Most of the synthesized compounds showed significantly decreased activities, which suggests that the long aliphatic side chain of micromolide and its double bond are essential to its activity. | 18,774,716 |
Three-dimensional motion of the scapula and shoulder during activities of daily living. | The purpose of this study was to describe 3-dimensional scapular motion during the activities of daily living (ADL) and the full range of arm motion, and to suggest a standardized method for evaluating scapular mobility. Eight healthy subjects between the ages of 25-40, with no prior history of shoulder pathology or su... | 18,774,735 |
Severe skin necrosis after breast reconstruction with a transverse rectus abdominis musculocutaneous flap in methylenetetrahydrofolate reductase deficiency. | We report a case of unexpected severe skin necrosis after autologous transverse rectus abdominis musculocutaneous flap breast reconstruction in a patient with homozygosis for the 5,10- methylenetetrahydrofolate reductase (MTHFR) gene. This genetic deficiency is hypothesised as the cause of this exceptional skin necrosi... | 18,774,766 |
Core protein phosphorylation facilitates the repair of photodamaged photosystem II at high light. | Phosphorylation of photosystem II (PSII) reaction center protein D1 has been hypothesised to function as a signal for the migration of photodamaged PSII core complex from grana membranes to stroma lamellae for concerted degradation and replacement of the photodamaged D1 protein. Here, by using the mutants with impaired... | 18,774,768 |
Ion chemistry of 1H-1,2,3-triazole. 2. Photoelectron spectrum of the iminodiazomethyl anion and collision induced dissociation of the 1,2,3-triazolide ion. | The 363.8 nm photoelectron spectrum of the iminodiazomethyl anion has been measured. The anion is synthesized through the reaction of the hydroxide ion (HO-) with 1 H-1,2,3-triazole in helium buffer gas in a flowing afterglow ion source. The observed spectrum exhibits well-resolved vibronic structure of the iminodiazom... | 18,774,783 |
Vibrational anharmonicity and harmonic force fields for dichloromethane from quantum-chemical calculations. | Anharmonic and related constants have been calculated for CH2Cl2, CD2Cl2, and CHDCl2 by using the program Gaussian03 and B3LYP and MP2 models. Bases used were 6-311++G** and cc-pVTZ. The size of grid used in the B3LYP/6-311++G** model had a noticeable effect on resulting data. Features of the MP2/6-311++G** calculation... | 18,774,789 |
Influence of ligand polarizability on the reversible binding of O2 by trans-[Rh(X)(XNC)(PPh3)2] (X = Cl, Br, SC6F5, C2Ph; XNC = xylyl isocyanide). Structures and a kinetic study. | The complexes trans-[Rh(X)(XNC)(PPh 3) 2] (X = Cl, 1; Br, 2; SC 6F 5, 3; C 2Ph, 4; XNC = xylyl isocyanide) combine reversibly with molecular oxygen to give [Rh(X)(O 2)(XNC)(PPh 3) 2] of which [Rh(SC 6F 5)(O 2)(XNC)(PPh 3) 2] ( 7) and [Rh(C 2Ph)(O 2)(XNC)(PPh 3) 2] ( 8) are sufficiently stable to be isolated in crystall... | 18,774,795 |
Magnetic field affects enzymatic ATP synthesis. | The rate of ATP synthesis by creatine kinase extracted from V. xanthia venom was shown to depend on the magnetic field. The yield of ATP produced by enzymes with 24Mg2+ and 26Mg2+ ions in catalytic sites increases by 7-8% at 55 mT and then decreases at 80 mT. For enzyme with 25Mg2+ ion in a catalytic site, the ATP yiel... | 18,774,801 |
Fluorescent signaling based on sulfoxide profluorophores: application to the visual detection of the explosive TATP. | The first visual fluorescence-based assay for the peroxide explosive triacetone triperoxide (TATP) is described. The assay is based on a conceptually new fluorescence signaling mechanism, in which nonemissive pyrenyl sulfoxide profluorophores are oxidized to visibly emissive pyrenyl sulfones. Although not without limit... | 18,774,810 |
Low coordinate, monomeric molybdenum and tungsten(III) complexes: structure, reactivity and calculational studies of (silox)3Mo and (silox)3ML (M = Mo, W; L = PMe3, CO; silox = (t)Bu3SiO). | Treatment of (silox)3MCl (M = Mo, 1-Cl; W, 2-Cl; silox = (t)Bu3SiO) with PMe3 and Na/Hg led to formation of monomeric, d(3) phosphine adducts, (silox)3MPMe3 (M = Mo, 1-PMe3; W, 2-PMe3) via (silox)3ClMPMe3 (M = Mo, 1-ClPMe3; W, 2-ClPMe3). Structural studies show 1-PMe3 and 2-PMe3 to be highly distorted; calculations on ... | 18,774,815 |
An expeditious synthesis of C(3)-N(1') heterodimeric indolines. | This paper describes the efficient and relatively simple synthesis of C(3)-N(1') heterodimeric indolines from the addition of indole nucleophiles to readily available bromopyrroloindolines. | 18,774,822 |
Cantilever tip near-field surface-enhanced Raman imaging of tris(bipyridine)ruthenium(II) on silver nanoparticles-coated substrates. | The near-field surface-enhanced Raman scattering (SERS) and surface-enhanced fluorescence (SEF) images of tris(bipyridine)ruthenium(II) adsorbed on a silver nanoparticles-coated substrate were obtained with a scanning near-field optical microscope (SNOM, or near-field scanning optical microscopy, NSOM) using a cantilev... | 18,774,828 |
Synthesis and surface self-assembly of [3]rotaxane-porphyrin conjugates: toward the development of a supramolecular surface tweezer for C60. | Surface immobilization of pristine C60 by supramolecular interactions is an attractive way to introduce C60 on surfaces since the pi-electron network and the electronic properties of C60 remain intact. Several hosts have been developed for surface complexation of C60. With few exceptions, the hosts reported to date are... | 18,774,831 |
In-situ heating study on the structural change of surfactant-templated germanium oxide mesostructure. | Mesostructured germanium oxide has been well-synthesized by using a surfactant-templated approach under basic hydrothermal conditions. The cationic surfactant cetyltrimethylammonium bromide (CTAB) has formed nanotubes with uniform diameter of about 3.2 nm. Blanket-like morphology of the as-prepared sample has been obse... | 18,774,850 |
Total synthesis of hyacinthacine A1, a glycosidase inhibitor. | A practical and enantioselective total synthesis of hyacinthacine A1 is achieved involving syn allylic epoxide opening with retention using Pd catalysis and "domino" hydrogenation (five steps in one pot) sequences. | 18,774,860 |
11-Hydroxymonocerin from the plant endophytic fungus Exserohilum rostratum. | A new analogue of monocerin, 11-hydroxymonocerin (2), along with monocerin (1) and 12-hydroxymonocerin (3) were isolated from cultures of Exserohilum rostratum, a fungal strain endophytic in Stemona sp. The structure of 2 was determined by analysis of NMR and MS data and by comparison of spectroscopic data to those of ... | 18,774,863 |
Sources and types of discrepancies between electronic medical records and actual outpatient medication use. | Accuracy and transportability of the recorded outpatient medication list are important in the continuum of patient care. Classifying discrepancies between the electronic medical record (EMR) and actual drug use by the root cause of discrepancy (either system generated or patient generated) would guide quality improveme... | 18,774,872 |
Economic and clinical impact of multiple myeloma to managed care. | Because of the development of novel agents such as immunomodulators, proteasome inhibitors, and bisphosphonates, the standards of care for the multiple myeloma (MM) patient have changed. The costs associated with current and emerging therapies, as well as supportive care, are significant and pose a tremendous financial... | 18,774,882 |
High prevalence of prolonged norovirus shedding and illness among hospitalized patients: a model for in vivo molecular evolution. | During a 2-year survey in an academic hospital, 8 (8.4%) of all norovirus (NoV)-positive patients showed prolonged norovirus illness and shedding (duration, 21-182 days). All patients had underlying illnesses, resulting in some level of immunodeficiency in 5. Four patients were admitted to the hospital with gastroenter... | 18,774,885 |
Prescription medication borrowing and sharing among women of reproductive age. | The purpose of this study was to describe the patterns of prescription medication borrowing and sharing among adults, particularly women of reproductive age. Data were collected from the 2001-2006 HealthStyles surveys, an annual mail survey conducted in the United States concerning trends in health behavior. The total ... | 18,774,892 |
Improving reversal median computation using commuting reversals and cycle information. | In the past decade, genome rearrangements have attracted increasing attention from both biologists and computer scientists as a new type of data for phylogenetic analysis. Methods for reconstructing phylogeny from genome rearrangements include distance-based methods, MCMC methods, and direct optimization methods. The l... | 18,774,904 |
Molecular mechanisms and clinical implications of reversible protein S-glutathionylation. | Sulfhydryl chemistry plays a vital role in normal biology and in defense of cells against oxidants, free radicals, and electrophiles. Modification of critical cysteine residues is an important mechanism of signal transduction, and perturbation of thiol-disulfide homeostasis is an important consequence of many diseases.... | 18,774,901 |
Plasmid DNA as a safe gene delivery vehicle for treatment of chronic inflammatory disease. | The development of plasmid DNA (pDNA) vectors for safe and efficacious gene transfer therapy for chronic inflammatory diseases is a natural sequel to biological therapies which, whilst effective, are relatively expensive, require frequent administration and are not suitable for all patients. To outline the methods of n... | 18,774,919 |
Ad-MDA-7; INGN 241: a review of preclinical and clinical experience. | The melanoma differentiation-associated gene-7 (MDA-7) was isolated while screening for upregulated genes in terminally differentiated melanoma cell lines. Preclinical studies attempted to test the theory that oncogenesis arises from a cellular differentiation process culminating in dysregulation of the cell cycle and ... | 18,774,929 |
Metal cofactors play a dual role in Mycobacterium tuberculosis inorganic pyrophosphatase. | Inorganic pyrophosphatase from Mycobacterium tuberculosis (Mt-PPase) is one of the possible targets for the rational design of anti-tuberculosis agents. In this paper, functional properties of this enzyme are characterized in the presence of the most effective activators--Mg2+ and Mn2+. Dissociation constants of Mt-PPa... | 18,774,936 |
Cardiac autonomic function and baroreflex changes following 4 weeks of resistance versus aerobic training in individuals with pre-hypertension. | Cardiac autonomic modulation and baroreflex sensitivity (BRS) are altered in individuals with hypertension. Aerobic exercise (AE) training has been shown to improve both measures, yet little is known about the effects of resistance exercise (RE). The purpose of this study was to examine the heart rate variability (HRV)... | 18,774,947 |
An enhanced level of motor cortical excitability during the control of human standing. | The study examined the role of the motor cortex in the control of human standing. Subjects (n = 15) stood quietly with or without body support. The supported standing condition enabled subjects to stand with a reduced amount of postural sway. Peripheral electrical stimulation, transcranial magnetic stimulation (TMS) or... | 18,774,948 |
Oxidative stress in NPC1 deficient cells: protective effect of allopregnanolone. | Niemann-Pick C disease (NPC) is an autosomal recessive neurodegenerative disorder caused by the abnormal function of NPC1 or NPC2 proteins, leading to an accumulation of unesterified cholesterol and glycosphingolipids (GSLs) in the lysosomes. The mechanisms underlying the pathophysiology in NPC disease are not clear. O... | 18,774,957 |
ABCB19/PGP19 stabilises PIN1 in membrane microdomains in Arabidopsis. | Auxin transport is mediated at the cellular level by three independent mechanisms that are characterised by the PIN-formed (PIN), P-glycoprotein (ABCB/PGP) and AUX/LAX transport proteins. The PIN and ABCB transport proteins, best represented by PIN1 and ABCB19 (PGP19), have been shown to coordinately regulate auxin eff... | 18,774,968 |
Insulin allergy desensitization with simultaneous intravenous insulin and continuous subcutaneous insulin infusion. | Persistent 'IgE-mediated' insulin allergy (type 1 allergy) (1), unresponsive to changes in insulin type or the use of antihistamines, necessitates desensitization. A number of case reports (2-7) and recent reviews (8, 9) have demonstrated that desensitization can be achieved with continuous subcutaneous insulin infusio... | 18,775,000 |
Early onset of type I diabetes mellitus, Hashimoto's thyroiditis and celiac disease in a 7-yr-old boy with Down's syndrome. | Patients with Down's syndrome are at higher risk for developing autoimmune diseases than those of the general population. Autoimmune diseases like Hashimoto's thyroiditis, Graves' disease, diabetes mellitus type I, celiac disease, autoimmune chronic active hepatitis, alopecia, vitiligo and hypoparathyroidism are recogn... | 18,775,001 |
Balloon occlusion and hypothermic perfusion of the renal artery in laparoscopic partial nephectomy. | We describe our initial experience with renal arterial catheterization for temporary balloon occlusion of renal artery and hypothermic perfusion during laparoscopic partial nephectomy and compare the preoperative and postoperative nephron function. Fifteen patients received laparoscopic partial nephrectomy from Septemb... | 18,775,030 |
The effect of a pedometer-based community walking intervention "Walking for Wellbeing in the West" on physical activity levels and health outcomes: a 12-week randomized controlled trial. | Recent systematic reviews have suggested that pedometers may be effective motivational tools to promote walking. However, studies tend to be of a relatively short duration, with small clinical based samples. Further research is required to demonstrate their effectiveness in adequately powered, community based studies. ... | 18,775,062 |
Effects of glatiramer acetate on fatigue and days of absence from work in first-time treated relapsing-remitting multiple sclerosis. | Treatment of multiple sclerosis patients with glatiramer acetate has been demonstrated a beneficial effect on disease activity. The objective of this prospective naturalistic study was to evaluate the impact of glatiramer acetate on fatigue and work absenteeism. 291 treatment-naïve patients with relapsing remitting mul... | 18,775,064 |
Radiographic outcome of surgical treatment of adolescent idiopathic scoliosis in males versus females. | Studies on adolescent idiopathic scoliosis have well documented the differences between natural history of male and female patients. There are also differences in responses to nonoperative treatment, but the results of operative treatment in male patients compared with females have not been widely reported. Only few st... | 18,775,076 |
Surgery vs. radiotherapy in localized prostate cancer. Which is best? | Surgery and radiotherapy are currently accepted alternatives for the treatment of localized prostate cancer. In the absence of relevant randomized trials no decision regarding the superiority of any of the given approaches can be made. Up to now several cohort-based approaches indicate similar outcomes for both treatme... | 18,775,078 |
Rb and hematopoiesis: stem cells to anemia. | The retinoblastoma protein, Rb, was one of the first tumor suppressor genes identified as a result of the familial syndrome retinoblastoma. In the period since its identification and cloning a large number of studies have described its role in various cellular processes. The application of conditional somatic mutation... | 18,775,080 |
Memory impairment in young women at increased risk of depression: influence of cortisol and 5-HTT genotype. | Memory deficits are common in depressed patients and may persist after recovery. The aim of the present study was to determine whether memory impairments were present in young women at increased familial risk of depression and whether memory performance was related either to cortisol secretion or to allelic variation i... | 18,775,088 |
Metazoan parasites of freshwater cyprinid fish ( Leuciscus cephalus): testing biogeographical hypotheses of species diversity. | The diversity and similarity of parasite communities is a result of many determinants widely considered in parasite ecology. In this study, the metazoan parasite communities of 15 chub populations (Leuciscus cephalus) were sampled across a wide geographical range. Three hypotheses of biogeographical gradients in specie... | 18,775,091 |
Brain morphometry volume in autistic spectrum disorder: a magnetic resonance imaging study of adults. | Several prior reports have found that some young children with autism spectrum disorder [ASD; including autism and Asperger's syndrome and pervasive developmental disorder - not otherwise specified (PDD-NOS)] have a significant increase in head size and brain weight. However, the findings from older children and adults... | 18,775,096 |
The composition of mineral waters sourced from Europe and North America in respect to bone health: composition of mineral water optimal for bone. | The consumption of mineral waters is increasing in industrialised countries. High intakes of Ca and other alkalising cations as well as a low acid intake are beneficial to bone. We examined which components of mineral waters are conditioning their Ca content and their alkalinising power, in order to define the optimal ... | 18,775,101 |
Cell cycle proteins preceded neuronal death after chronic cerebral hypoperfusion in rats. | To explore the re-expression of cell cycle related proteins and delayed neuronal death after chronic cerebral hypoperfusion in rats and to investigate the relationship between aberrant expression of cell cycle proteins and apoptotic cell death. Rat model of chronic cerebral hypoperfusion was established by permanent bi... | 18,775,106 |
QT interval in newborns of different ethnic origin: usefulness of neonatal ECG screening. | The cost-effectiveness of neonatal electrocardiographic (ECG) screening has been questioned. The objective of this study was to establish normal values for the QT interval in newborns of different ethnic origin. Between 2005 and 2006, ECGs were obtained during the first 48 h of life from 1305 at-term newborns at the Ho... | 18,775,242 |
Four years of surveillance of recent HIV infections at country level, France, mid 2003 - 2006: experience and perspectives. | New systems of surveillance to better monitor the dynamics of HIV are needed. A national surveillance of new HIV diagnoses which included the collection of dried serum spots (DSS) to identify recent infections (<6 months) using an EIA-RI assay was implemented in 2003 in France. The collection of DSS is based on the ... | 18,775,291 |
Principles and uses of HIV incidence estimation from recent infection testing--a review. | Since the 1990s, the development of laboratory-based methods has allowed to estimate incidence of human immunodeficiency virus (HIV) infections on single samples. The tests aim to differentiate recent from established HIV infection. Incidence estimates are obtained by using the relationship between prevalence, incidenc... | 18,775,292 |
Transcriptional ShortCUTs. | Recent work from Kuehner and Brow (2008) and Thiebaut et al. (2008) in Molecular Cell and Jenks et al. (2008) in Molecular and Cellular Biology reveals that regulated expression of central nucleotide synthesis pathway components directs start site-dependent RNA polymerase II termination. | 18,775,320 |
Pediatric tracheal stenosis. | Tracheal stenosis is a rare, potentially life-threatening condition described as innate narrowing of the tracheal lumen. The causes of tracheal stenosis vary widely. The most common forms result from prolonged intubation, although congenital causes usually involve complete tracheal rings or compression from cardiovascu... | 18,775,347 |
Assessment and pharmacologic treatment of sleep disturbance in autism. | Like children with other developmental disabilities, children with autism spectrum disorders suffer with sleep problems at a higher rate than do typically developing children. There is a growing recognition that addressing these sleep problems may improve daytime functioning and decrease family stress. Presented here i... | 18,775,369 |
Developing drugs for core social and communication impairment in autism. | There are many challenges to studying drug effects on core social and language impairment in autism. Drugs such as fenfluramine, naltrexone, and secretin do not appear to be efficacious for these core symptoms. Risperidone has led to improvement in some aspects of social relatedness when used to treat irritability in a... | 18,775,370 |
Assessment and behavioral treatment of feeding and sleeping disorders in children with autism spectrum disorders. | Children diagnosed with autism or autism spectrum disorders (ASD) are more likely than other children to exhibit behaviors characteristic of a feeding or sleeping disorder. Parents of children with these disorders may be extremely concerned about the health and safety of their child. Sleeping and feeding problems can c... | 18,775,376 |
Evaluation of integrative medicine supplements for mitigation of chronic insomnia and constipation in an inpatient eating disorders setting. | The aim of this study was to determine whether patients with eating disorders used fewer conventional sleep and constipation medications when given integrative medicine interventions. Retrospective data from two cohorts were compared; the eating disorder group (ED) received only conventional treatments for insomnia and... | 18,775,402 |
Role of sex and time of blood sampling in SOD1 and SOD2 expression variability. | This study investigates how some of human physiological parameters, in particular sex and daytime, can contribute to the normal variation in blood gene expression. The expressions of two genes: SOD1 (Cu/Zn) and SOD2 (Mn) in white blood cells of 19 healthy individuals (10 men and 9 women) were examined by qPCR at 09.00,... | 18,775,420 |
The role of Mac-1 (CD11b/CD18) in osteoclast differentiation induced by receptor activator of nuclear factor-kappaB ligand. | Multinuclear osteoclasts are derived from CD11b-positive mononuclear cells in bone marrow and in circulation. FACS sorting experiments showed impaired osteoclastogenesis in RAW264.7 cells with low CD11b expression. Neutralizing antibodies and siRNA against CD11b inhibited osteoclastogenesis induced by RANKL. Although p... | 18,775,427 |
Detection of humoral response in patients with glioblastoma receiving EGFRvIII-KLH vaccines. | The epidermal growth factor receptor variant III (EGFRvIII) is a consistent tumor-specific mutation that is widely expressed in glioblastoma multiforme (GBM) and other neoplasms. As such it represents a truly tumor-specific target for antitumor immunotherapy. Although endogenous humoral responses to EGFRvIII have been ... | 18,775,433 |
Reduced-volume cues effectively support fear conditioning despite sleep deprivation. | Sleep deprivation impairs contextual but not cued learned fear, and it has been suggested that this pattern reflects an insensitivity of the amygdala to sleep loss. The lack of effect of sleep deprivation on cued conditioning, however, might simply be due to the strong attention drawn by the typically loud cue tone. We... | 18,775,445 |
3'-Fluoro substitution in the pyridine ring of epibatidine improves selectivity and efficacy for alpha4beta2 versus alpha3beta4 nAChRs. | The analog of epibatidine having a fluoro substituent at the 3' position of the pyridine ring has been recently developed and shown to possess binding affinity in the pM range to alpha4beta2 nAChRs and in the nM range to alpha7 nAChRs and to exhibit potent agonist activity in nicotine-induced analgesia tests. Here we u... | 18,775,444 |
Methylated N-(4-pyridinylmethyl) chitosan as a novel effective safe gene carrier. | The objective of this study was to study the transfection efficiency of quaternized N-(4-pyridinylmethyl) chitosan; TM-Py-CS, using the pDNA encoding green fluorescent protein (pEGFP-C2) on human hepatoma cell lines (Huh 7 cells). The factors affecting the transfection efficiency, e.g. degree of quaternization (DQ), th... | 18,775,484 |
Current in vitro methods in nanoparticle risk assessment: limitations and challenges. | Nanoparticles are an emerging class of functional materials defined by size-dependent properties. Application fields range from medical imaging, new drug delivery technologies to various industrial products. Due to the expanding use of nanoparticles, the risk of human exposure rapidly increases and reliable toxicity te... | 18,775,492 |
The CCT/TRiC chaperonin is required for maturation of sphingosine kinase 1. | Sphingosine kinase 1 (SK1) catalyses the generation of sphingosine 1-phosphate (S1P), a bioactive phospholipid that influences a diverse range of cellular processes, including proliferation, survival, adhesion, migration, morphogenesis and differentiation. SK1 is controlled by various mechanisms, including transcriptio... | 18,775,504 |
Cleavage of syndecan-4 by ADAMTS1 provokes defects in adhesion. | Syndecan-4 is a membrane-bound heparan sulfate proteoglycan that participates in cell-cell and cell-matrix interactions and modulates adhesion and migration of many cell types. Through its extracellular domain, syndecan-4 cooperates with adhesion molecules and binds matrix components relevant for cell migration. Import... | 18,775,505 |
Occurrence and structural organization of the exocrine glands in the legs of ants. | Apart from their obvious locomotory function and hence the presence of muscle fibres, ant legs are also endowed with an astonishing variety of exocrine glands. This paper reviews the presence and structural variety of the 20 different glands that have so far been found in the legs of ants. Four of these glands are desc... | 18,775,512 |
Short-term intraocular pressure changes immediately after intravitreal injections of anti-vascular endothelial growth factor agents. | To assess short-term trends and the need to monitor intraocular pressure (IOP) changes immediately after intravitreal injections of ranibizumab, bevacizumab, pegaptanib, and triamcinolone acetonide. Retrospective, interventional case series. Charts of 213 consecutive injections to 120 eyes of 112 patients were reviewed... | 18,775,528 |
Centile charts of cervical length between 18 and 32 weeks of gestation. | To establish a centile chart of cervical length between 18 and 32 weeks of gestation in a low-risk population of women. A prospective longitudinal cohort study of women with a low risk, singleton pregnancy using public healthcare facilities in Cape Town, South Africa. Transvaginal measurement of cervical length was per... | 18,775,533 |
Quantification of 2,5-dimethyl-4-hydroxy-3(2H)-furanone using solid-phase extraction and direct microvial insert thermal desorption gas chromatography-mass spectrometry. | A GC-MS method for the determination of furaneol in fruit juice was developed using Lichrolut-EN solid-phase extraction (SPE) coupled to microvial insert thermal desorption. Lichrolut-EN can effectively extract furaneol from juice, and had much less retention for pigments and other non-volatiles than HLB and C18 column... | 18,775,541 |
Context-influenced cap-independent translation of Tombusvirus mRNAs in vitro. | Tomato bushy stunt virus (TBSV) possesses a positive-strand RNA genome that is not 5'-capped or 3'-polyadenylated. Previous analysis revealed that the TBSV genome contains a 3'-cap-independent translational enhancer (3'CITE) in its 3'-untranslated region (3'UTR) that facilitates translation of viral mRNAs in vivo. A lo... | 18,775,547 |
Identifying useable semen. | The "predictors of useable semen" used in most commercial AI centers provide a very conservative estimate of the relative fertility of individual boars. Furthermore, the relatively high sperm numbers used in commercial AI practice (usually >3 x10(9) total sperm per dose of extended semen) usually compensate for redu... | 18,775,561 |
In vitro and in vivo evidence for lack of endovascular remodeling by third trimester trophoblasts. | The placental-decidual interaction through invading trophoblasts determines whether a physiological transformation of the uterine spiral arteries is established or not. Trophoblast-orchestrated artery remodeling is central to normal placentation. Dysregulated uteroplacental interaction and vascular remodeling are thoug... | 18,775,564 |
Report of the 3rd Havemeyer workshop on allergic diseases of the Horse, Hólar, Iceland, June 2007. | Allergic diseases occur in most mammals, although some species such as humans, dogs and horses seem to be more prone to develop allergies than others. In horses, insect bite hypersensitivity (IBH), an allergic dermatitis caused by bites of midges, and recurrent airway obstruction (RAO), a hyperreactivity to stable born... | 18,775,570 |
Cracking neural circuits in a tiny brain: new approaches for understanding the neural circuitry of Drosophila. | Genetic screens in Drosophila have identified many genes involved in neural development and function. However, until recently, it has been impossible to monitor neural signals in Drosophila central neurons, and it has been difficult to make specific perturbations to central neural circuits. This has changed in the past... | 18,775,572 |
Association of psychiatric and substance use disorder comorbidity with cocaine dependence severity and treatment utilization in cocaine-dependent individuals. | The relations among psychiatric and substance dependence disorders and treatment utilization are of interest both for their clinical management and for health services. We examined these relations using six self-reported indices of cocaine dependence severity and three self-reported measures of treatment utilization an... | 18,775,607 |
[Treatment of chronic hepatitis B]. | In recent years, marked progress has been made in the treatment of chronic hepatitis B. Several agents have been approved: interferon alpha-(IFN), pegylated interferon alpha2a (PEG-IFN alpha2a), lamivudine, adefovir, entecavir, telbivudine and recently, tenofovir. Each drug has advantages and limitations. IFN and PEG-I... | 18,775,613 |
The effects of extended-release naltrexone on holiday drinking in alcohol-dependent patients. | A post hoc analysis examined the effect of extended-release naltrexone (XR-NTX) treatment combined with psychosocial support on alcohol consumption during holiday and nonholiday periods in a cohort of alcohol-dependent patients who had maintained at least 4 days of continuous abstinence before receiving their first tre... | 18,775,624 |
Assessing the effectiveness of an Internet-based videoconferencing platform for delivering intensified substance abuse counseling. | Enhanced schedules of counseling can improve response to routine opioid-agonist treatment, although it is associated with increased time demands that enhance patient resistance and nonadherence. Internet-based counseling can reduce these concerns by allowing patients to participate from home. This study assesses treatm... | 18,775,625 |
Micro-metastases in stages I and II colon cancer are a predictor of the development of distant metastases and worse disease-free survival. | Approximately 30% of the patients with Dukes A/B colon carcinoma will develop loco-regional recurrence or distant metastases. The aim of this study was to evaluate if patients with micro-metastases are at higher risk for developing distant metastases and therefore a worse disease-free survival and overall survival. In ... | 18,775,627 |
[French hospital doctors attend many educational programmes but have organisational and financial difficulties for their continuing medical education]. | Few data on the educational needs and practices of the French hospital doctors have been obtained through surveys. Considering that the CME information is now available on www.cnfmc.fr and that providers were accredited, we investigated, on a representative sample of hospital doctors, the CME practices and the knowledg... | 18,775,631 |
Visual MRI: merging information visualization and non-parametric clustering techniques for MRI dataset analysis. | This paper presents Visual MRI, an innovative tool for the magnetic resonance imaging (MRI) analysis of tumoral tissues. The main goal of the analysis is to separate each magnetic resonance image in meaningful clusters, highlighting zones which are more probably related with the cancer evolution. Such non-invasive anal... | 18,775,655 |
Infections in a surgical intensive care unit of a university hospital in Greece. | We aimed to evaluate the clinical and microbiological characteristics of the patients who developed an infection in our surgical intensive care unit (SICU). This was a prospective study of all patients who sustained an ICU-acquired infection from 2002 to 2004. Among 683 consecutive SICU patients, 123 (18.0%) developed ... | 18,775,663 |
Rotavirus-associated infantile diarrhea in Uberaba, Minas Gerais, on the wake of the Brazilian vaccination program. | Rotaviruses are major causes of diarrhea in children for which vaccines were developed and are currently in use. To investigate the genotypes of rotavirus strains causing dehydrating diarrhea in children in Uberaba, Triângulo Mineiro region, Minas Gerais, during 2005-2006. Rotavirus-associated diarrhea was investigated... | 18,775,667 |
The antagonistic effect of antipsychotic drugs on a HEK293 cell line stably expressing human alpha1A1-adrenoceptors. | Antipsychotic drugs often cause orthostatic hypotension, probably through antagonist action on resistance vessel alpha(1A)-adrenoceptors. Here we have tested this possibility directly using cells transfected with a relevant human alpha(1A)-adrenoceptor splice variant. To determine a splice variant which was relevant, w... | 18,775,692 |
A conserved dibasic site is essential for correct processing of the peptide hormone AtRALF1 in Arabidopsis thaliana. | Prohormone proteins in animals and yeast are typically processed at dibasic sites by convertases. Propeptide hormones are also found in plants but little is known about processing. We show for the first time that a dibasic site upstream of a plant peptide hormone, AtRALF1, is essential for processing. Overexpression of... | 18,775,699 |
delta-Opioid receptors stimulate ERK1/2 activity in NG108-15 hybrid cells by integrin-mediated transactivation of TrkA receptors. | This study demonstrates that activation of delta-opioid receptors (DORs) in neuroblastomaxglioma (NG108-15) hybrid cells by [D-Ala2, D-Leu5]enkephalin (DADLE) and etorphine significantly enhances cell adhesion to fibronectin-coated wells. This effect is blocked by both naloxone and integrin binding RGDT peptides. In ad... | 18,775,707 |
The role of a conserved histidine residue in a pyruvate-specific Class II aldolase. | Histidine 45 in HpaI was replaced with alanine (H45A) and glutamine (H45Q). In the aldol cleavage reaction, kcat values were lowered by 78- and 2059-fold while Km values were increased by 100- and 42-fold in H45A and H45Q, respectively, compared to the wild-type enzyme. Both mutants displayed higher dissociation consta... | 18,775,708 |
Misacylation of pyrrolysine tRNA in vitro and in vivo. | Methanosarcina barkeri inserts pyrrolysine (Pyl) at an in-frame UAG codon in its monomethylamine methyltransferase gene. Pyrrolysyl-tRNA synthetase acylates Pyl onto tRNAPyl, the amber suppressor pyrrolysine Pyl tRNA. Here we show that M. barkeri Fusaro tRNAPyl can be misacylated with serine by the M. barkeri bacterial... | 18,775,710 |
Effective Tityus serrulatus anti-venom produced using the Ts1 component. | Scorpion stings are a public health problem in Brazil, with most incidents involving the species Tityus serrulatus. Some T. serrulatus toxins may act as immunogens for the production of a specific anti-venom, but many of the component toxins remain poorly characterized. Here, we describe the immunological characteristi... | 18,775,739 |
Anatomical particularities of the porcine immune system--a physician's view. | In this article the anatomical structure of the porcine immune organs is described. The focus is on their particularities that are related to the use of pigs as an animal model. Key issues of the intrauterine development of the lymphoid organs are presented, such as the specific epithelio-chorial placenta, the appearan... | 18,775,744 |
The role of ethnic identity and perceived ethnic norms in the purchase of ethnical food products. | The role of group and individual variables in the purchasing of ethnical food products was tested through an extended theory of planned behavior (TPB) model. A total of 100 Indian female immigrants, living in Rome, Italy, were administered a self-reported questionnaire measuring the classical TPB variables (attitudes, ... | 18,775,756 |
Mutations that affect coenzyme binding and dimer formation of fungal 17beta-hydroxysteroid dehydrogenase. | The 17beta-hydroxysteroid dehydrogenase from the fungus Cochliobolus lunatus (17beta-HSDcl) is an NADPH-dependent member of the short-chain dehydrogenase/reductase superfamily, and it functions as a dimer that is composed of two identical subunits. By constructing the appropriate mutants, we have examined the M204 resi... | 18,775,764 |
Lymphocyte recruitment to the liver: molecular insights into the pathogenesis of liver injury and hepatitis. | Recirculation of blood lymphocytes through the liver occurs under normal conditions as part of the process of immune surveillance. In response to injury or infection recruitment from blood increases and the nature and distribution of the infiltrate will determine the type and outcome of the resulting hepatitis. Recruit... | 18,775,762 |
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