title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Two novel myocilin mutations in a Chinese family with primary open-angle glaucoma. | To investigate the genetic linkage of primary open-angle glaucoma (POAG) in a Chinese family. We have screened for myocilin (MYOC) gene mutations in a glaucoma family of five generations. There are fifty-six members of whom 11 were confirmed to have POAG , two with ocular hypertension were considered as POAG suspect, a... | 18,776,955 |
Percutaneous septal ablation after unsuccessful surgical myectomy for patients with hypertrophic obstructive cardiomyopathy. | To evaluate the long-term outcome of percutaneous septal ablation (PTSMA) after a previous myectomy. Myectomy usually results in symptomatic improvement and reduction of dynamic obstruction in hypertrophic obstructive cardiomyopathy patients (HOCM-pts.). However, a few pts. remain with severe symptoms and obstruction, ... | 18,777,001 |
Wheat germ lipase catalyzed kinetic resolution of secondary alcohols in non-aqueous media. | The lipase from wheat germ was used for the kinetic resolution of secondary alcohols. It has the opposite enantioselectivity against the Kazlauskas rule and acts as an anti-Kazlauskas catalyst. The effect of initial water activity, organic solvent, acyl donor and temperature were investigated. Wheat germ lipase had a h... | 18,777,014 |
[Lupus erythematodes--evidence-based recommendations for monitoring and therapy]. | Standard care of patients with systemic lupus erythematosus (SLE) covers continuous extended diagnostics including the search for new disease manifestations, evaluation of disease activity and of comorbidities requiring treatment and, in particular, accompanying infections. Immunosuppressive medication is determined by... | 18,777,026 |
[Effectiveness of arthroscopic synovectomy in rheumatoid arthritis]. | Arthroscopic synovectomy in rheumatoid arthritis has proven beneficial in terms of pain relief and joint function, both for upper limb joints (shoulder, elbow, wrist) and the knee. The clinical long-term improvement, such as pain reduction and improved joint mobility, seems more distinct in joints with no or mild joint... | 18,777,027 |
Incidence of diabetes mellitus among children of Italian migrants substantiates the role of genetic factors in the pathogenesis of type 1 diabetes. | To investigate the role of genetic and environmental factors in the pathogenesis of type 1 diabetes mellitus (T1D), we carried out a study in Germany aimed at comparing the prevalence and incidence of T1D among children of migrant Italians from high-risk (Sardinia) and low-risk (continental Italy) regions versus German... | 18,777,043 |
Flow curves of colloidal dispersions close to the glass transition. Asymptotic scaling laws in a schematic model of mode coupling theory. | The flow curves, viz. the curves of stationary stress under steady shearing, are obtained close to the glass transition in dense colloidal dispersions using asymptotic expansions in the schematic F₁₂(γ)-model of mode coupling theory. The shear thinning of the viscosity in fluid states and the yielding of glassy states ... | 18,777,045 |
Endothelial dysfunction and inflammatory reactions of elderly and middle-aged men with obstructive sleep apnea syndrome. | Obstructive sleep apnea syndrome (OSAS) is considered to be associated with cardiovascular complications, and atherosclerosis could mediate this relationship. Cardiovascular risk factors of OSAS still need to be elucidated in elderly patients, since studies about the association between OSAS and cardiovascular diseases... | 18,777,130 |
Feed intake, digestibility, body weight and carcass parameters of Afar rams fed tef (Eragrostis tef) straw supplemented with graded levels of concentrate mix. | The experiment was conducted at Alamata Agricultural Research Center, Ethiopia using 20 Afar rams with an initial body weight (BW) of 18.2 +/- 1.76 (mean +/- SD) kg. The objectives were to study the effect of supplementation with concentrate mix consisting of wheat bran (WB), noug seed cake (NSC) and sesame seed cake (... | 18,777,140 |
Acute toxicity of atrazine, endosulfan sulphate and chlorpyrifos to Vibrio fischeri, Thamnocephalus platyurus and Daphnia magna, relative to their concentrations in surface waters from the Alentejo region of Portugal. | Ecotoxicological effects of the herbicide atrazine and the insecticides endosulfan sulphate and chlorpyrifos were evaluated using a test battery comprising aquatic organisms from different trophic levels. According to the categories established in the EU legislation, atrazine can be considered non-harmful for the speci... | 18,777,155 |
Differential lipid profile and hormonal response in type 2 diabetes by exogenous insulin aspart versus the insulin secretagogue repaglinide, at the same glycemic control. | Our aim was to study, at the same glycemic control, how treatment with either the insulin secretagogue repaglinide or exogenous insulin aspart affects endogenous insulin secretion, plasma insulin and IAPP (islet amyloid polypeptide) levels, GH-IGF (growth hormone-insulin-like growth factor) axis and plasma lipoprotein ... | 18,777,156 |
Ethanol production from H(2)SO (3)-steam-pretreated fresh sweet sorghum stem by simultaneous saccharification and fermentation. | The present work presents an alternative approach to ethanol production from sweet sorghum: without detoxification, acid-impregnated fresh sweet sorghum stem which contains soluble (glucose and sucrose) and insoluble carbohydrates (cellulose and hemicellulose) was steam pretreated under mild temperature of 100 degrees ... | 18,777,165 |
Transformation of different barley (Hordeum vulgare L.) cultivars by Agrobacterium tumefaciens infection of in vitro cultured ovules. | Most cultivars of higher plants display poor regeneration capacity of explants due to yet unknown genotypic determined mechanisms. This implies that technologies such as transformation often are restricted to model cultivars with good tissue characteristics. In the present paper, we add further evidence to our previous... | 18,777,178 |
Differences in perceptions of communication, tourism benefits, and management issues in a protected area of rural Kenya. | With record-breaking tourist visits in Kenya in 2005-2006, communities near the country's renowned protected areas must undertake or revisit planning efforts to conserve and enhance the region's natural, social, and economic resources. This article examines the differences between two stakeholder groups in the Samburu ... | 18,777,191 |
Collecting 48,000 CT exams for the lung screening study of the National Lung Screening Trial. | From 2002-2004, the Lung Screening Study (LSS) of the National Lung Screening Trial (NLST) enrolled 34,614 participants, aged 55-74 years, at increased risk for lung cancer due to heavy cigarette smoking. Participants, randomized to standard chest X-ray (CXR) or computed tomography (CT) arms at ten screening centers, r... | 18,777,192 |
Efficacy of the electrothermal bipolar vessel sealer in laparoscopic spleen-preserving distal pancreatectomy with conservation of the splenic artery and vein. | Laparoscopic spleen-preserving distal pancreatectomy (LSPDP) with conservation of the splenic artery and vein has recently been performed as a minimally invasive surgery to retain splenic function in the treatment of pancreatic diseases. As the branches of the splenic vessels are very delicate, division of these branch... | 18,777,196 |
Improving recruitment and retention for an online randomized controlled trial: experience from the Youthnet study. | The objective of the study was to present recruitment and retention findings for an Internet based HIV prevention trial evaluated using a randomized controlled design among 15-25-year-olds accessing a website on the Internet. We used a combination of automated electronic and personalized approaches to increase and dive... | 18,777,217 |
Out-of-pocket costs of AIDS care in China: are free antiretroviral drugs enough? | Financial access to HIV care and treatment can be difficult for many people in China, where the government provides free antiretroviral drugs but does not cover the cost of other medically necessary components, such as lab tests and drugs for opportunistic infections. This article estimates out-of-pocket costs for trea... | 18,777,223 |
Impact of substance-induced and general medical condition exclusion criteria on the prevalence of common mental disorders as defined by the CIDI. | It has been previously argued that the methodology used by the Composite International Diagnostic Interview version 2.1 to assess the substance-induced and general medical condition exclusion criteria are inadequate. As a result prevalence estimates generated from epidemiological studies using this interview may be und... | 18,777,235 |
Application of ion exchange resin in floating drug delivery system. | The purpose of this study was to explore the application of low-density ion exchange resin (IER) Tulsion(R) 344, for floating drug delivery system (FDDS), and study the effect of its particle size on rate of complexation, water uptake, drug release, and in situ complex formation. Batch method was used for the preparati... | 18,777,244 |
Characterization of alpha,alpha-trehalase released in the intestinal lumen by the probiotic Saccharomyces boulardii. | Trehalose intolerance due to alpha,alpha-trehalase deficiency has scarcely been studied. The purpose of this study was to measure alpha,alpha-trehalase activity in intestinal biopsy samples from 200 consecutive patients over a period of 6 months, and to characterize alpha,alpha-trehalase released by the probiotic Sacch... | 18,777,247 |
Chlortetracycline impregnated food-pellets for the prophylaxis and therapy of psittacosis/ornithosis in psittacines and pigeons. | Medicated food containing 5000 p.p.m. chlortetracycline (CTC) was used for the prophylaxis and therapy of psittacosis/ornithosis in approximately 3800 seed-eating psittacines representing 40 species of 22 genera, as well as 600 pigeons. On the basis of high blood levels of CTC (mostly over 1 mug/ml) in psittacines and ... | 18,777,265 |
The specific characters of the Eimeria, with special reference to the coccidia of the fowl. | The differentiation of species of Eimeria is discussed with special reference to those occurring in the domestic fowl. Details of the morphology of the oocysts and other developmental stages of the parasites, their location in the host and the characteristics of the lesions produced, the timing of the patent and prepat... | 18,777,269 |
Observations on the serological and dermal responses of turkeys to a single subcutaneous inoculation of inactivated Newcastle disease vaccine in mineral oil adjuvant. | Each of 10 growing turkeys given a primary subcutaneous inoculation of inactivated Newcastle disease vaccine in mineral oil adjuvant responded with the production of virus-neutralizing (VN) and haemagglutination-inhibiting (HI) antibodies. Biphasic modulation of the serological response was more evident with HI than wi... | 18,777,275 |
Fowl peritoneal exudate cells: collection and use for the macrophage migration inhibition test. | A method for the collection of fowl peritoneal exudate cells and their use in macrophage migration inhibition tests is described. | 18,777,285 |
A technique for separating oocysts from faeces. | A technique to separate oocysts from large amounts of faeces by a "Continuous-Flow-Different-Density-Flotation" method is presented. Measures to save labour and to decrease the risk of contaminating the laboratory as well as the oocyst isolate during the centrifugation and harvesting of the oocysts from the centrifuge ... | 18,777,295 |
Spray vaccination of turkeys against Newcastle disease. | Turkeys poults were vaccinated against Newcastle disease by spray vaccination using Hitchner B1 and La Sota vaccines. Turkeys with maternally derived immunity vaccinated at 7, 35 and 63 days of age developed an active immunity. Each revaccination resulted in higher levels of haemagglutination-inhibiting and neutralisin... | 18,777,335 |
Clinical and pathological observations on field and experimental zoalene poisoning in broiler chicks and the effect of the drug on laying hens. | Depression and ataxia was seen in 24-day-old chicks accidentally fed excess zoalene from 14 days of age. The presence of a small amount of furazolidone in the ration probably exacerbated the effect. There were no deaths. No other causes could be found for the condition and replacing the rations with food containing les... | 18,777,343 |
[Influence of Eimeria acervulina duodenal coccidiosis on intestinal absorption of lysine and on the movement of water and electrolytes]. | The absorption rate of 14C L-lysine and net flux of water and mineral ions (Na+, K+) were studied in 4-week-old male chickens infected with Eimeria acervulina (10(6) sporulated oocysts/chicken). Intestinal coccidiosis significantly decreased absorption rate of 14C-lysine. This effect was particularly pronounced in the ... | 18,777,344 |
Determination of haematology and blood chemistry values in healthy six-week old broiler hybrids. | Fourteen "comparison values" were determined for 6-week-old broilers. A total of 980 birds were sampled from 21 flocks to provide "comparison values" for body weight and blood characteristics. Production and management details are described and sources of variation in the "comparison values" within and between flocks a... | 18,777,356 |
Resistance of field isolates of Eimeria species to anticoccidial drugs. | A study was made of the incidence of coccidial oocysts in the litter of a broiler house used for commercial trials. The following anticoccidial drugs were under investigation: zoalene, Pancoxin, Lerbek and monensin. Monensin was the only drug able to suppress the numbers of oocysts appearing in the litter. Two species ... | 18,777,357 |
Mycoplasma synoviae in the guinea-fowl. | A mycoplasma strain, isolated from natural synovitis of guinea-fowl, was identified as Mycoplasma synoviae. In experimental infection this agent showed clear pathogenicity for guinea-fowl, and to a lesser degree for chickens. In guinea-fowl the strain was more likely to result in synovitis and amyloidosis when inoculat... | 18,777,358 |
Titers of precipitins in strains of chickens exposed to Marek's disease. | Titers of precipitating antibody against Marek's disease (MD) herpesvirus were determined on serum collected from five strains of chickens at intervals throughout the 411 day test period. The average titers for the genetically resistant Cornell K strain were consistently higher (P <.01) than for the genetically susc... | 18,777,379 |
An age-related resistance of chickens to Marek's disease: some preliminary observations. | Chickens of 2 strains, 20 to 22 weeks of age and free of prior infection, were substantially more resistant than l-day-old chicks to mortality and tumor induction caused by exposure to Marek's disease virus. These older chickens were refractory to inoculation with up to 10(4) chick tumor-inducing doses of Marek's disea... | 18,777,381 |
Delayed hypersensitivity and leucocyte migration inhibition in chickens with BCG or Marek's disease infection. | Production of Migration Inhibition Factor in vitro by lymphocytes from chickens with delayed hypersensitivity was examined. Chickens were sensitized with Bacille Calmette-Guerin (BCG) and others with Marek's Disease (MD) virus. Peripheral blood was used as a source of cells for in vitro radial migration inhibition. Usi... | 18,777,382 |
Observations on host range and control of goose virus hepatitis. | A number of experiments were done with a strain of goose hepatitis virus (isolated from sick goslings in the Netherlands in 1969. This virus was easily grown in embryonating eggs of the Muscovy duck (Cairina moschata) as well as in embryonating goose eggs. It also proved possible to adapt it to White Pekin duck eggs. T... | 18,777,395 |
Lead poisoning in domestic and wild ducks. | The results of clinical, radiological, hematological, histomorphological and toxicological research carried out on experimental lead poisoning of domestic and Wild ducks are reported and discussed. Radiological, histological and toxicological investigations were aimed at determining the most characteristic features for... | 18,777,397 |
Continuing medical education: AMEE Education Guide No 35. | This guide is designed to provide a foundation for developing effective continuing medical education (CME) for practicing physicians. For the purposes of this work, continuing medical education is defined as any activity which serves to maintain, develop, or increase the knowledge, skills and professional performance a... | 18,777,424 |
Learning and metaphors. | All thought and talk about learning involves the use of metaphors. Whilst metaphors aid our understanding of things by suggesting novel insights, they can also mislead if too much is read into the supposed likenesses. Acquisition and transfer are easily the most popular metaphors used to understand learning. This artic... | 18,777,427 |
Bus use and older people: a literature review applying the Person-Environment-Occupation model in macro practice. | The same reasons that prompt older people to give up driving can also result in difficulties with accessing public transport. Difficulties using public transport can limit older people's participation in society, thereby impacting negatively on their health. Focusing on public buses, this review explicates the link bet... | 18,777,441 |
The vascular trigger of type II diabetes mellitus. | Type II diabetes mellitus is associated with obesity and insulin resistance. However, many humans with these symptoms never develop diabetes. This raises the key question of the difference that determines why one obese individual develops diabetes, whereas another one does not. Here we review the experimental support f... | 18,777,448 |
[Thenar hammer syndrome]. | Chronic traumatic aneurysm of the distal radial artery is rare. The literature offers only 20 cases of chronic traumatic vascular lesions of the thenar region. We present the case of a 58-year-old cheese maker who had done manual work for years and who experienced swelling at the thenar eminence, pain, cold and warm pa... | 18,777,469 |
Considerations in the choice of an antiepileptic drug in the treatment of epilepsy. | The advent of multiple new antiepileptic drugs (AEDs) in the past 15 years has provided new options for clinicians treating patients with epilepsy, but has also created a need for guidelines in AED use. For selection of the most appropriate AED, the neurologist must know the pharmacological properties of the AEDs and h... | 18,777,477 |
T1rho-prepared balanced gradient echo for rapid 3D T1rho MRI. | To develop a T1rho-prepared, balanced gradient echo (b-GRE) pulse sequence for rapid three-dimensional (3D) T1rho relaxation mapping within the time constraints of a clinical exam (<10 minutes), examine the effect of acquisition on the measured T1rho relaxation time and optimize 3D T1rho pulse sequences for the knee... | 18,777,535 |
MRI diagnosis of brown tumor based on magnetic susceptibility. | A 56-year-old male with chronic renal failure was incidentally found to have lytic bone lesions in the pubic symphysis, left femoral head, left acetabulum, left iliac bone, and L1 vertebra on computed tomography (CT). Subsequent magnetic resonance imaging (MRI) of the abdomen was performed (for evaluation of a renal le... | 18,777,537 |
Evaluation of locally recurrent pelvic malignancy: performance of T2- and diffusion-weighted MRI with image fusion. | To evaluate the performance of T2- and diffusion-weighted magnetic resonance imaging (MRI) with image fusion for detection of locally recurrent pelvic malignancy. The study group consisted of 28 patients (27 female, 1 male) who underwent pelvic MRI at 1.5 T after treatment of pelvic malignancy. MR images were reviewed ... | 18,777,555 |
Assessment of fluctuating velocities in disturbed cardiovascular blood flow: in vivo feasibility of generalized phase-contrast MRI. | To evaluate the feasibility of generalized phase-contrast magnetic resonance imaging (PC-MRI) for the noninvasive assessment of fluctuating velocities in cardiovascular blood flow. Multidimensional PC-MRI was used in a generalized manner to map mean flow velocities and intravoxel velocity standard deviation (IVSD) valu... | 18,777,557 |
Stromal myofibroblasts are drivers of invasive cancer growth. | Tissue integrity is maintained by the stroma in physiology. In cancer, however, tissue invasion is driven by the stroma. Myofibroblasts and cancer-associated fibroblasts are important components of the tumor stroma. The origin of myofibroblasts remains controversial, although fibroblasts and bone marrow-derived precurs... | 18,777,559 |
Discriminating accuracy of medial temporal lobe volumetry and fMRI in mild cognitive impairment. | We investigated structural and functional changes in the medial temporal lobe (MTL) using magnetic resonance imaging (MRI) and compared the discriminative power of these measures with neuropsychological testing in mild cognitive impairment (MCI) and Alzheimer's disease (AD). Functional MRI (fMRI) was performed in 21 el... | 18,777,563 |
Accumulation of yolk in a caecilian (Gegeneophis ramaswamii) oocyte: a light and transmission electron microscopic study. | There is a paucity of information on the female reproductive biology of the caecilian amphibians when compared with the other vertebrate groups. Hence, the accumulation of nutrient reserves in the form of yolk and formation of yolk platelets were studied in Gegeneophis ramaswamii, adopting light microscopic histologica... | 18,777,571 |
Protein adsorption resistance and oxygen permeability of chemically crosslinked phospholipid polymer hydrogel for ophthalmologic biomaterials. | The biomimetic structure of a polymer hydrogel bearing phosphorylcholine groups was obtained from 2-methacryloyloxyethylphosphorylcholline (MPC) and a novel crosslinker, 2-(methacryloyloxy)ethyl-N-(2-methacryloyloxy)ethyl]phosphorylcholine (MMPC), to prepare biocompatible ocular materials. MMPC is a dimethacrylate with... | 18,777,582 |
Enhanced therapeutic effects for human pancreatic cancer by application K-ras and IGF-IR antisense oligodeoxynucleotides. | To investigate the combined effects of K-ras antisense oligodeoxynucleotide (K-ras ASODN) specific to GTT point mutation at codon 12 and type I insulin-like growth factor receptor (IGF-IR) antisense oligodeoxynucleotide (IGF-IR ASODN) on proliferation and apoptosis of human pancreatic cancer Patu8988 cells in vitro and... | 18,777,594 |
Nigella sativa relieves the deleterious effects of ischemia reperfusion injury on liver. | To determine whether Nigella sativa prevents hepatic ischemia-reperfusion injury to the liver. Thirty rats were divided into three groups as sham (Group 1), control (Group 2), and Nigella sativa (NS) treatment group (Group 3). All rats underwent hepatic ischemia for 45 min followed by 60 min period of reperfusion. Rats... | 18,777,598 |
Innate immunity to Paracoccidioides brasiliensis infection. | Innate immunity is based in pre-existing elements of the immune system that directly interact with all types of microbes leading to their destruction or growth inhibition. Several elements of this early defense mechanism act in concert to control initial pathogen growth and have profound effect on the adaptative immune... | 18,777,631 |
Coma falsely attributed to Lyme disease. | Neuroborreliosis has very low prevalence in Kentucky and coma due to Lyme disease is uncommon in North America. A patient diagnosed with Lyme disease in Kentucky, based on coma, typical inflammatory changes on brain imaging, and a positive ELISA resulted in an erroneous clinical impression. Diagnosis should have been c... | 18,777,697 |
[Frequency of diseases and injuries in the Swiss horse population]. | Through a written questionnaire, which was sent to a representatively distributed and randomly selected sample of Swiss horse owners, data of 2912 horses and ponies were acquired to extrapolate prevalence data of health disorders. General questions about the horse and associated factors of housing and use, as well as q... | 18,777,726 |
[Acromioclavicular lesions: diagnosis and treatment]. | Acromioclavicular trauma is a frequent pathology of the upper limb. Stages 1 and 2 don't required surgery. On the other hand more severe lesions (stages 3-6) often need a surgical care, even if there is not any consensus about the most appropriate treatment. We reviewed here the main steps in the diagnosis and treatmen... | 18,777,734 |
[Treatment by enlargement of septal perforations]. | Assessment of surgical posterior enlargement for septal perforation. Ten patients included had a symptomatic perforation in area 2 and/or 3 of Cottle. The size of the perforations was superior at 10 mm. This is a retrospective study. The surgical procedure has consisted of an initial corection of anterior septal deviat... | 18,777,768 |
[Reconstruction of a transfixing partial loss of substance from the wing of nose with the upper pedicled nasolabial flap]. | The reconstruction of the wing of the nose is a surgical challenge. The aim of the reconstruction is both aesthetic and functional. The nasolabial flap with upper pedicule returned, described by Préaux in 1994, appears to be successful for this challenge. The advantages of this flap include simplicity, reliability, one... | 18,777,769 |
Post-traumatic otosclerosis: coincidence or trigger factor? | The etiology of otosclerosis is poorly understood and environmental as well as genetic factors have been implicated. In this paper we will present 3 cases of otosclerosis with a clinical history of trauma and we will discuss with a literature review the place of trauma in otosclerosis etiology. 3 patients with clinical... | 18,777,771 |
Pain relief to a point. | Acupuncture can help to relieve some of the discomfort and pain associated with pregnancy. Midwife Sarah Budd has been practising the technique for 20 years. | 18,777,832 |
Correlation of Fourier domain optical coherence tomography retinal nerve fiber layer maps with visual fields in nonarteritic ischemic optic neuropathy. | To correlate peripapillary retinal nerve fiber layer (NFL) loss and visual field defects in nonarteritic ischemic optic neuropathy (NAION). Patients with NAION and control subjects were enrolled in a case-control study. Participants were scanned with a Fourier domain optical coherence tomography (OCT) system. Peripapil... | 18,777,877 |
These are wonderful people. | The position of academic dean in a dental school affords an opportunity to observe young men and women growing into professionals. I have seen numerous quite acts of thoughtful kindness and unselfish service. I have also witnessed the personal struggles of students working through their academic dishonesty and the chal... | 18,777,884 |
Dental students persuade the Michigan Dental Association to strengthen its codes of ethics: do actions speak louder than words? | This is a case study of how four different groups viewed proposed language in professional ethics codes regarding personal relationships with patients. The ADA Council on Ethics, Bylaws, and Judicial Affairs; the House of Delegates of the Michigan State Dental Association; and first-year students at the University of M... | 18,777,889 |
Novel approach for the Monte Carlo calculation of free-air chamber correction factors. | A self-consistent approach for the Monte Carlo calculation of free-air chamber (FAC) correction factors needed to convert the chamber reading into the quantity air-kerma at the point of measurement is introduced, and its implementation in the new EGSnrc user code egs_fac is discussed. To validate the method, comparison... | 18,777,925 |
Accuracy of cranial coplanar beam therapy using an oblique, stereoscopic x-ray image guidance system. | A system for measuring two-dimensional (2D) dose distributions in orthogonal anatomical planes in the cranium was developed and used to evaluate the accuracy of coplanar conformal therapy using ExacTrac image guidance. Dose distributions were measured in the axial, sagittal, and coronal planes using a CIRS (Computerize... | 18,777,940 |
Helping parents decide on ADHD treatment for their children. | In the United States, medication is often the first intervention used to treat attention-deficit/hyperactivity disorder (ADHD). Yet psychosocial interventions with both parents and teachers working together to shape the child's behavior can also be an effective approach, enabling smaller amounts of medication to be use... | 18,777,965 |
Health services utilization and cost utility analysis of a walking program for residential community elderly. | Promoting the health and improving the ability and confidence of the elderly to live independently can reduce health care expenditures and increase the health of society as a whole. However, the evidence to promote physical activity in order to promote health among the aged population is weak, especially in regards to ... | 18,777,976 |
[Anticardiolipin and anti-beta2 glycoprotein-1 antibodies patients with breast carcinoma: a pilot study]. | Thrombosis - the main manifestation of antiphospholipid syndrome (APS) - is at the same time observed in some patients with malignancies. Evaluation of prevalence of some antiphospholipid antibodies (aPL) in serum of patients with breast carcinoma and the possible correlation between aPL seropositivity and clinical sym... | 18,778,015 |
[The management of pregnant women with antiphospholipid syndrome]. | Antiphospholipid syndrome (APS) is associated with several pregnancy complications as: intrauterine growth restriction, preeclampsia, premature abrubtion of the placenta as well as an increased risk of deep vein thrombosis (DVT). Treatment in this disease is still equivocal. The aim is to reduce the level of circulatin... | 18,778,021 |
[Beta2 glycoprotein-I--the main antigen in antiphospholipid syndrome]. | The term "antiphospholipid antibodies" describing a laboratory hallmark of antiphospholipid syndrome (APS) is a misnomer. It suggests that antibodies are directed against phospholipids. Meanwhile the specific antigens are in fact proteins demonstrating an affinity to phospholipids. In APS antibodies directed against a ... | 18,778,023 |
[Therapy resistance antiphosholipid syndrome in the course of systemic lupus erythematosus: case report]. | Antiphospholipid syndrome (APS) is one of the most common reasons of thromboembolic complications in the course of connective tissue diseases. There is a strong relationship between presence of antiphospholipid antibodies and the risk of thrombosis. APS related thromboembolic complications range from superficial vein t... | 18,778,025 |
Directed assembly of chiral oxidovanadium(V) methoxides into C4-symmetric metal(I) vanadate-centered quadruplexes: synergistic K+- and Ag+-specific transport. | A directed assembly process to form C4-symmetric, vanadate-centered quadruplexes, for the first time, from a given chiral oxidovanadium(V) complex allows for highly efficient K+- and Ag+-specific transport from aqueous phase containing three other alkali metal cations into organic solvents, reminiscent of the K+ specif... | 18,778,056 |
Intra/intermolecular direct allylic alkylation via Pd(II)-catalyzed allylic C-H activation. | The first catalytic direct alkylation of allylic C-H bonds via Pd(II)-catalysis is described in the absence of base. Polysubstituted cyclic compounds can also be constructed by the intramolecular direct allylic alkylation. | 18,778,061 |
Energy transfer in new D-pi-A conjugated dendrimers: their synthesis and photophysical properties. | A series of new D-pi-A conjugated dendrimers based on benzothiadiazole and triphenylamine were developed via facile synthetic approaches. By changing the types of bridges between the different functional moieties of these dendrimers, their photophysical properties, especially the intramolecular energy transfer process,... | 18,778,080 |
Identification of cytochrome P450 enzymes involved in the metabolism of the designer drugs N-(1-phenylcyclohexyl)-3-ethoxypropanamine and N-(1-phenylcyclohexyl)-3-methoxypropanamine. | The involvement of human hepatic cytochrome P450 isoenzymes (P450s) in the metabolism of the designer drugs N-(1-phenylcyclohexyl)-3-ethoxypropanamine (PCEPA) and N-(1-phenylcyclohexyl)-3-methoxypropanamine (PCMPA) to the common metabolite N-(1-phenylcyclohexyl)-3-hydroxypropanamine (PCHPA) was studied using insect cel... | 18,778,087 |
Potent inhibition of human phosphodiesterase-5 by icariin derivatives. | Plant extracts traditionally used for male impotence (Tribulus terrestris, Ferula hermonis, Epimedium brevicornum, Cinnamomum cassia), and the individual compounds cinnamaldehyde, ferutinin, and icariin, were screened against phosphodiesterase-5A1 (PDE5A1) activity. Human recombinant PDE5A1 was used as the enzyme sourc... | 18,778,098 |
Intramolecular 1,8-hydrogen atom transfer. Stereoselectivity of the hexopyranos-5'-yl radical reactions in Hex p-(1-->4)-Hex p disaccharide systems. | The stereoselective reduction of hexopyranos-5'-yl radicals in alpha-D-Hex p-(1-->4)-D-Hex p disaccharide models is described. These radicals are generated from a 6-O-yl radical located in the other monosaccharic unit through a 1,8-hydrogen atom transfer. The reaction, which is strongly influenced by steric and ster... | 18,778,104 |
Spotlight on enoxaparin in ST-segment elevation myocardial infarction. | Enoxaparin (enoxaparin sodium; Lovenox) is a low-molecular-weight heparin (LMWH) that has recently been approved by the US FDA for use in patients with medically managed ST-segment myocardial infarction (STEMI), or STEMI with subsequent percutaneous coronary intervention. It binds to and potentiates the action of antit... | 18,778,116 |
The magnitude of binocular disparity modulates search time for targets defined by a conjunction of depth and colour. | Nakayama and Silverman (1986) proposed that, when searching for a target defined by a conjunction of color and stereoscopic depth, observers partition 3D space into separate depth planes and then rapidly search each such plane in turn, thereby turning a conjunctive search into a "feature" search. In their study, they f... | 18,778,143 |
Assessment of generalized anxiety disorder diagnostic criteria in the National Comorbidity Survey and Virginia Adult Twin Study of Psychiatric and Substance Use Disorders. | The authors investigated measurement properties of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition, generalized anxiety disorder (GAD) criteria in the National Comorbidity Survey and the Virginia Adult Twin Study of Psychiatric and Substance Use Disorders (VATSPSUD). The two studies used diffe... | 18,778,157 |
Analyzing the convergent and discriminant validity of states and traits: development and applications of multimethod latent state-trait models. | The analysis of convergent and discriminant validity is an integral part of the construct validation process. Models for analyzing the convergent and discriminant validity have typically been developed for cross-sectional data. There exist, however, only a few approaches for longitudinal data that can be applied for an... | 18,778,163 |
On the dimensionality of the Dispositional Hope Scale. | The Dispositional Hope Scale (DHS; C. R. Snyder et al., 1991) consists of two subsets of items measuring Agency and Pathways. The authors used bifactor analysis to evaluate the dimensionality structure of the scale. Data from 676 persons (295 psychiatric patients, 112 delinquents, and 269 students) were analyzed. The a... | 18,778,168 |
Advances in the medical management of Cushing's syndrome. | Management of Cushing's syndrome, that is, excess cortisol secretion, has undergone considerable advances since the pioneering studies by Harvey Cushing. Surgery is clearly first choice for all etiologies of Cushing's syndrome, and medical therapy is largely administered in the interim between other therapeutic options... | 18,778,181 |
Effects of shielding adenoviral vectors with polyethylene glycol on vector-specific and vaccine-mediated immune responses. | Many individuals have been previously exposed to human adenovirus serotype 5 (Ad5). This prior immunity has long been known to hinder its use for gene therapy and as a gene-based vaccine. Given these immunogenicity problems, we have tested whether polyethylene glycol (PEG) can blunt immune effects against Ad5 during sy... | 18,778,197 |
Effect of IL-6 deficiency on susceptibility to HSV-1 respiratory infection and intrinsic macrophage antiviral resistance. | Cytokines play important roles in the mechanisms of disease development. Interleukin-6 (IL-6) is associated with clearance of herpes simplex virus (HSV) infections and in virus-induced immunopathology. However, the importance of IL-6 in host defense against HSV-1 respiratory infection is unknown. This study tested the ... | 18,778,200 |
Assessing the validity of measures of an instrument designed to measure employees' perceptions of workplace breastfeeding support. | Breastfeeding rates among working mothers are lower than among mothers who are not employed. An ecological framework suggests that health behaviors, such as breastfeeding, are influenced by intrapersonal and environmental factors. There is no existing instrument to measure women's perception of the workplace environmen... | 18,778,210 |
Health care-associated infection (HAI): a critical appraisal of the emerging threat-proceedings of the HAI Summit. | During the Health Care-Associated Pneumonia Summit conducted in June 2007, it was found that there is a need for educational efforts in several areas of health care-associated infections (HAI) that extend beyond pneumonia. This supplement to Clinical Infectious Diseases represents the proceedings of the HAI Summit, a d... | 18,778,223 |
A low-cost flow cytometric assay for the detection and quantification of apoptosis using an anionic halogenated fluorescein dye. | We describe here a technical improvement of an established colorimetric method used to detect and measure the occurrence of apoptosis in mammalian cells during in vitro cell culture. This assay uses an anionic halogenated fluorescein dye that is taken up by apoptotic cells at the stage of phosphatidylserine externaliza... | 18,778,255 |
Modeling the effects of anthropogenic habitat change on savanna snake invasions into African rainforest. | We used a species-distribution modeling approach, ground-based climate data sets, and newly available remote-sensing data on vegetation from the MODIS and Quick Scatterometer sensors to investigate the combined effects of human-caused habitat alterations and climate on potential invasions of rainforest by 3 savanna sna... | 18,778,269 |
Comparative genome analysis of a Saccharomyces cerevisiae wine strain. | Many industrial strains of Saccharomyces cerevisiae have been selected primarily for their ability to convert sugars into ethanol efficiently despite exposure to a variety of stresses. To begin investigation of the genetic basis of phenotypic variation in industrial strains of S. cerevisiae, we have sequenced the genom... | 18,778,279 |
Genomic expression analysis by single-cell mRNA differential display of quiescent CD8 T cells from tumour-infiltrating lymphocytes obtained from in vivo liver tumours. | We performed a genomic study combining single-cell mRNA differential display and RNA subtractive hybridization to elucidate CD8 T-cell quiescence/ignorance. By comparing actively maintained quiescent CD8 T cells from liver tumour tumour-infiltrating lymphocytes (TILs) with quiescent T cells at the single-cell level, we... | 18,778,280 |
Increased secretion of hyperimmune antibodies following lipopolysaccharide stimulation of CD40-activated human B cells in vitro. | Human B cells can be cultured ex vivo for a few weeks, following stimulation of the CD40 cell surface molecule in the presence of recombinant cytokines such as interleukin-4 (IL-4). However, attempts to produce polyclonal antigen-specific human antibodies by in vitro culture of human B cells obtained from immunized don... | 18,778,289 |
Characterization of the recognition and functional heterogeneity exhibited by cytokine-induced killer cell subsets against acute myeloid leukaemia target cell. | The polyclonal cytokine-induced killer (CIK) cells exhibit potent cytotoxicity against a variety of tumour cells including autologous and allogeneic acute myeloid leukaemic (AML) targets. At maturity, three lymphocyte subsets: CD3(-) CD56(+), CD3(+) CD56(-) and CD3(+) CD56(+), constitute the bulk of the CIK cell cultur... | 18,778,291 |
Mechanisms for recycling and biosynthesis of endogenous cannabinoids anandamide and 2-arachidonylglycerol. | The mechanisms of endogenous cannabinoid biosynthesis are not completely understood. We hypothesized that anandamide could be recycled by the cell to form new endocannabinoid molecules and released into the extracellular space. We determined that new endocannabinoids derived from exogenous anandamide or arachidonic aci... | 18,778,304 |
Obesity status and sick leave: a systematic review. | This review identified 36 studies on the relation between obesity status and sick leave. Pooling of effect estimates was not possible due to great heterogeneity between studies regarding definition of sick leave (short-term/long-term), measure of obesity (body mass index/waist circumference/percentage body fat), defini... | 18,778,315 |
Expression of rat beta(1,4)-N-acetylglucosaminyltransferase III in Nicotiana tabacum remodels the plant-specific N-glycosylation. | Plant N-linked glycans differ substantially from their mammalian counterparts, mainly with respect to modifications of the core glycan, which typically contains a beta(1,2)-xylose and an alpha(1,3)-fucose. The addition of a bisecting N-acetylglucosamine residue by beta(1,4)-N-acetylglucosaminyltransferase III (GnTIII) ... | 18,778,316 |
Syntactic anomaly elicits a lexico-semantic (N400) ERP effect in the second language but not the first. | Recent brain potential research into first versus second language (L1 vs. L2) processing revealed striking responses to morphosyntactic features absent in the mother tongue. The aim of the present study was to establish whether the presence of comparable morphosyntactic features in L1 leads to more similar electrophysi... | 18,778,320 |
Polymorphism of HLA-DRB1, -DQB1 and -DPB1 genes in Bai ethnic group in southwestern China. | In this work, polymorphism of human leukocyte antigen (HLA)-DRB1, -DQB1 and -DPB1 genes was detected using polymerase chain reaction-sequence-based typing method in 128 healthy unrelated volunteers from the Bai ethnic group of Yunnan province of southwest China. Among all the 28 alleles detected for the DRB1 gene, the ... | 18,778,327 |
Harry Moss Traquair (1875-1954), Scottish ophthalmologist and perimetrist. | Harry Moss Traquair (1875-1954) was an Edinburgh Ophthalmologist, who was especially involved in the studies of perimetry and neuro-ophthalmology. In his monumental work, An Introduction to Clinical Perimetry, which for years was the standard textbook of perimetry, he included the description of the visual field as "an... | 18,778,336 |
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