title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Post-exposure targeting of specific epitopes on ricin toxin abrogates toxin-induced hypoglycemia, hepatic injury, and lethality in a mouse model. | Effects in the liver of fatal intoxication with the binary toxin ricin are unclear. We report a robust neutrophil influx into the liver of C57BL/6 mice after lethal parenteral ricin challenge, occurring in peri-portal and centro-lobular hepatic areas within 2 h, followed by the abrupt disappearance of hepatic macrophag... | 18,779,782 |
DNA-based patents: an empirical analysis. | The perception of rising litigation rates is driving the push for patent reform. | 18,779,808 |
Behavioral immunization: immunity to self-antigens contributes to psychological stress resilience. | The psychobiological mechanisms that contribute to the development of stress resilience are not fully elucidated. One potential approach for enhancing resilience is the exposure to mild challenges. According to this approach, a mildly stressful episode may immunize the individual, thereby strengthening resistance to su... | 18,779,818 |
Association of maternal dopamine transporter genotype with negative parenting: evidence for gene x environment interaction with child disruptive behavior. | Although maternal parenting is central to child development, little is known about the interplay between molecular genetic and environmental factors that influence parenting. We tested the association of the 40-bp variable number tandem repeat polymorphism of the dopamine transporter (DAT1; SLC6A3) gene with three dime... | 18,779,819 |
Thalidomide plus dexamethasone as primary therapy for newly diagnosed patients with multiple myeloma. | Thalidomide with dexamethasone (thal-dex) is an active therapy for patients with relapsed or refractory multiple myeloma (MM). In this Practice Point, we discuss the findings of a trial by Rajkumar et al. that aimed to compare the response rate, time to progression and progression-free survival among previously untreat... | 18,779,849 |
Elevated systemic antibodies towards commensal gut microbiota in autoinflammatory condition. | Familial Mediterranean fever (FMF) is an autoinflammatory condition, which is characterized by acute, self-limiting episodes of fever and serositis and chronic subclinical inflammation in remission. Here we investigated the consequence of this condition on the level of systemic antibodies directed towards common intest... | 18,779,861 |
Change in long-spacing collagen in Descemet's membrane of diabetic Goto-Kakizaki rats and its suppression by antidiabetic agents. | We examined changes in the ultrastructure and localization of major extracellular matrix components, including 5 types of collagen (type I, III, IV, VI, and VIII), laminin, fibronectin, and heparan sulfate proteoglycan in Descemet's membrane of the cornea of diabetic GK rats. In the cornea of diabetic GK rats, more lon... | 18,779,868 |
Pathogenicity of Chinese H5N1 highly pathogenic avian influenza viruses in pigeons. | It has long been thought that pigeons are resistant against H5 highly pathogenic avian influenza (HPAI) viruses. Recently, however, highly pathogenic H5N1 avian influenza viruses have demonstrated distinct biological properties that may be capable of causing disease in pigeons. To examine the susceptibility of domestic... | 18,779,923 |
Sequential anaerobic-aerobic degradation of munitions waste. | A sequential anaerobic-aerobic biodegradation of hexahydro-1,3,5-trinitro-1,3,5-triazine (RDX) was studied. The results demonstrated that: (i) a complete degradation of RDX was achieved within 20 days using a consortium of bacteria from a wastewater activated sludge, (ii) RDX degradation did not occur under aerobic con... | 18,779,925 |
Seasonal trends and tissue distribution of organochlorine pollutants in wild and farmed gilthead sea bream (Sparus aurata) from the Western Mediterranean Sea and their relationship with environmental and biological factors. | Seasonal trends and tissue distribution of organochlorine pesticides (OCPs) and polychlorinated biphenyls (PCBs) in gilthead sea bream (Sparus aurata) samples from the Western Mediterranean were investigated. Hexane extracts of white and red muscle, liver, and gills from wild and cultured specimens were purified by nor... | 18,779,940 |
Uterotrophic assay, Hershberger assay, and subacute oral toxicity study of 3-amino-1,2,4-triazole based on the Organization for Economic Co-operation and Development draft protocols. | We performed a uterotrophic assay, the Hershberger assay, and the 28-day repeated-dose toxicity study (enhanced OECD test guideline no. 407) of 3-amino-1,2,4-triazole based on the OECD draft protocols. In the uterotrophic assay, female SD rats were subcutaneously injected with the chemical at doses of 0, 100, 300, and ... | 18,779,953 |
Treatment of patients with advanced cardiac AL amyloidosis with oral melphalan, dexamethasone, and thalidomide. | Patients with primary (AL) amyloidosis and heart failure have a very poor prognosis and cannot tolerate aggressive therapy, such as autologous stem cell transplantation and high-dose dexamethasone-based regimens. We prospectively treated 22 patients with advanced cardiac amyloidosis combining oral melphalan, thalidomid... | 18,779,964 |
[Sudden visual loss in a 7-year old patient]. | A 7-year-old boy presented to us with a sudden bilateral decrease in visual acuity. At the age of 4 months bilateral congenital glaucoma had been diagnosed and trabeculotomy performed. Eye pressure and fundus were monitored regularly. Both magnetic resonance imaging and computed tomography revealed a giant supraclinoid... | 18,779,968 |
Linkage of 35S and 5S rRNA genes in Artemisia (family Asteraceae): first evidence from angiosperms. | Typically in plants, the 5S and 35S ribosomal DNA (rDNA) encoding two major ribosomal RNA species occur at separate loci. However, in some algae, bryophytes and ferns, they are at the same locus (linked arranged). Southern blot hybridisation, polymerase chain reactions (PCR), fluorescent in situ hybridisation, cloning ... | 18,779,974 |
Development of Thanatophilus micans (Fabricius 1794) (Coleoptera: Silphidae) at constant temperatures. | Thanatophilus micans is capable of finding corpses at least as quickly as most fly species and, as the most widespread species of the Silphidae in Africa, offers a useful model for estimating post-mortem interval. Larvae were reared at ten constant temperatures from 15 degrees C to 35 degrees C and their length measure... | 18,779,975 |
Monitoring demyelination and remyelination by magnetization transfer imaging in the mouse brain at 9.4 T. | The aim of this study was to assess quantitatively structural changes in myelin content occurring during demyelination and remyelination by magnetization transfer imaging (MTI). In a reversible model of demyelination with no axonal loss, mice intoxicated by cuprizone were studied by MTI in vivo at 9.4 T. MRI data were ... | 18,779,984 |
Correlation of echocardiographic markers and therapy in persistent pulmonary hypertension of the newborn. | Persistent pulmonary hypertension of the newborn (PPHN) causes morbidity and mortality in neonates. High-frequency ventilation (HFV), inhaled nitric oxide (iNO), and extracorporeal membrane oxygenation (ECMO) are used when conventional treatment fails. This study aimed to identify echocardiographic predictors of progre... | 18,779,989 |
Tuberculous pyomyositis of forearm muscles. | Tuberculous pyomyositis is a rare entity reported in literature. The presented case reports the occurrence of such a lesion in forearm muscles, without any bony involvement. The ambiguity in its diagnosis led to inadequate management by the primary care physician. Clinical suspicion, positive tuberculin test, culture o... | 18,780,002 |
Surgical treatment of thumb carpometacarpal joint arthritis: a single institution experience from 1995-2005. | There are numerous techniques for the surgical management of thumb carpometacarpal (CMC) joint arthritis. The four senior authors of this study employ three such techniques: trapeziectomy with hematoma distraction arthroplasty, hemitrapeziectomy with osteochondral allograft, and ligament reconstruction tendon interposi... | 18,780,018 |
Absent flexor pollicis longus: case report with review of literature. | An asymptomatic absence of flexor pollicis longus without association with any other anomaly or hypoplasia of the thenar muscles in a 28-year-old patient is reported due to its rarity. The inability to flex the interphalangeal joint of the thumb and the absent flexor crease of the thumb led us to identify the absent te... | 18,780,020 |
Flucloxacillin reduces stiffness following flexor tendon repair. | To determine the benefit of antibiotic prophylaxis on postoperative mobility in flexor tendon repairs, case notes of 72 flexor tendon injuries in twenty four patients were analyzed retrospectively (2001-2003). Only patients with non-contaminated injuries from sharp instruments in flexor zone 2 were included in the stud... | 18,780,024 |
Compression of the deep palmar branch of the ulnar nerve by a ganglion : a case report. | A ganglion originating from the pisotriquetral joint is the most common cause of distal ulnar nerve compression. Midpalmar ganglions causing ulnar nerve compression are rare. This case describes a ganglion arising from the third carpometacarpal joint causing compression of the deep motor branch of the ulnar nerve. | 18,780,033 |
Current status of outcomes research in carpal tunnel surgery. | More than 3,000 publications on carpal tunnel syndrome (CTS) have been presented in the literature. Although surgery for treating CTS is commonly performed, the outcomes of these surgical procedures are still relatively unclear. This paper will summarize relevant publications on the surgical treatment of CTS to critica... | 18,780,037 |
Treatment of distal radius fractures with percutaneous pinning and pin-in-plaster. | This article describes a modified technique that combines percutaneous pinning and casting. A prospective study was conducted on 54 patients with distal radius fracture who were treated with percutaneous Kirschner wire (K-wire) fixation and pin-in-plaster technique. The surgical indications of this technique included d... | 18,780,104 |
Cryopreservation of composite tissue transplants. | Composite tissue allotransplantation holds great promise for upper extremity reconstruction but is limited by donor part availability. Cryopreservation may increase the availability of donor parts and even reduce antigenicity. The purpose of the study was to evaluate the viability of cryopreserved composite tissues and... | 18,780,115 |
The safety of percutaneous trigger finger release. | This study attempted to determine the safety of percutaneous release of trigger fingers, with particular attention given to border digits and the thumb. We performed percutaneous release of the A1 pulley in six fresh frozen cadaveric hands utilizing established surface landmarks. After freezing all specimens, we perfor... | 18,780,120 |
Posttraumatic stress and complicated grief in family members of patients in the intensive care unit. | Family members of patients in intensive care units (ICUs) are at risk for mental health morbidity both during and after a patient's ICU stay. To determine prevalences of and factors associated with anxiety, depression, posttraumatic stress and complicated grief in family members of ICU patients. Prospective, longitudin... | 18,780,129 |
Bariatric surgery improves atherogenic LDL profile by triglyceride reduction. | Small dense low-density lipoprotein (LDL) are atherogenic particles frequently observed in obese patients. Fatty acids modulate LDL. Objective of this study was to determine the relations between plasma phospholipid fatty acid composition and the presence of small dense LDL particles in morbidly obese patients treated ... | 18,780,133 |
Role of protein flexibility in the design of Bcl-X(L) targeting agents: insight from molecular dynamics. | Detailed understanding of protein-ligand interactions is crucial to the design of more effective drugs. This is particularly true when targets are protein interfaces which have flexible, shallow binding sites that exhibit substantial structural rearrangement upon ligand binding. In this study, we use molecular dynamics... | 18,780,145 |
Structural and functional aspects of the MSP (PsbO) and study of its differences in thermophilic versus mesophilic organisms. | The Manganese Stabilizing Protein (MSP) of Photosystem II (PSII) is a so-called extrinsic subunit, which reversibly associates with the other membrane-bound PSII subunits. The MSP is essential for maximum rates of O(2) production under physiological conditions as stabilizes the catalytic [Mn(4)Ca] cluster, which is the... | 18,780,158 |
The multisite violence prevention project: impact of a universal school-based violence prevention program on social-cognitive outcomes. | This study evaluated the impact of a universal school-based violence prevention program on social-cognitive factors associated with aggression and nonviolent behavior in early adolescence. The effects of the universal intervention were evaluated within the context of a design in which two cohorts of students at 37 scho... | 18,780,181 |
Effects of Ramadan upon fluid and food intake, fatigue, and physical, mental, and social activities: a comparison between the UK and Libya. | Two studies were performed during Ramadan, one in the UK (N=31) and the other in Libya (N=33). The aims were to assess some changes to lifestyle that are produced by fasting as well as effects due to culture. Subjects were studied on eight separate occasions: four control days (two before and two after Ramadan) and fou... | 18,780,199 |
Day-night variations of serum interleukin-6 in patients with severe obstructive sleep apnea syndrome before and after continuous positive airway pressure (CPAP). | Obstructive sleep apnea syndrome (OSAS) causes intermittent hypoxia and increases in sympathetic activity and contributes to cardiovascular disorders. Interleukin-6 (IL-6) is one of the important proinflammatory cytokines. We examined the levels of serum IL-6 concentrations in nine patients with severe OSAS at four dif... | 18,780,208 |
Lead removal and toxicity reduction from industrial wastewater through biological sulfate reduction process. | The practicability of lead removal from sulfate-rich wastewater through biological sulfate reduction process with hydrogen as electron donor was investigated. Sulfide, which was converted from sulfate by a sulfate-reducing bacteria (SRB) in a gas-lift reactor, was used to remove lead as lead sulfide precipitate. Furthe... | 18,780,220 |
Soil-skin adherence from carpet: use of a mechanical chamber to control contact parameters. | A computer-controlled mechanical chamber was used to control the contact between carpet samples laden with soil, and human cadaver skin and cotton sheet samples for the measurement of mass soil transfer. Mass soil transfers were converted to adherence factors (mg/cm2) for use in models that estimate dermal exposure to ... | 18,780,223 |
Virus-host interaction in the simian immunodeficiency virus-infected brain. | With the increased survival of human immunodeficiency virus (HIV)-infected individuals resulting from therapy, disorders in other target organs of the virus, such as the brain, are becoming more prevalent. Here the author reviews his laboratory's work on the simian immunodeficiency virus (SIV)/nonhuman model of acquire... | 18,780,229 |
Behavioral and neurophysiological hallmarks of simian immunodeficiency virus infection in macaque monkeys. | Macaque monkeys infected with various neurovirulent forms of simian immunodeficiency virus (SIV) represent highly effective models, not only of systemic acquired immunodeficiency virus (AIDS), but also neuroAIDS. Behavioral studies with this model have clearly established that SIV-infected monkeys show both cognitive a... | 18,780,231 |
Characteristics of fatty acids and essential oil from sweet fennel (Foeniculum vulgare Mill. var. dulce) and bitter fennel fruits (F. vulgare Mill. var. vulgare) growing in Turkey. | Oil content in sweet and bitter fennels was obtained 12.22% and 14.41%, respectively. The C(18:1 c6), C(18:2), C(18:1 c9) and C(16:0) acids corresponding to approximately 97% of total oil was recorded as principal fatty acids. The ratios of essential oil from sweet and bitter fennels were found similar (average 3.00%).... | 18,780,240 |
Micropropagation and production of Camptothecin from in vitro plants of Ophiorrhiza rugosa var. decumbens. | Camptothecin and its derivatives are used as anticancer alkaloids. At present, they are obtained by the extraction from the Chinese tree Camptotheca acuminata and the indigenous tree Nothapodytes foetida. Identification of alternate species of plants like Ophiorrhiza species and development of tissue culture methods ma... | 18,780,241 |
Chemical composition of essential oil and headspace-solid microextracts from fruits of Myrica gale L. and antifungal activity. | The essential oil and the volatile compounds of Myrica gale fruits were analysed by gas chromatography (GC) and GC-mass spectrometry (GC-MS). The volatile compounds were detected using two different fibres for headspace-solid phase microextraction (HS-SPME), Carboxen/PDMS and PDMS. Sixty two compounds were identified, ... | 18,780,242 |
Isolation of antibacterial diterpenoids from Cryptomeria japonica bark. | The aims of the present study were to determine the antibacterial activity of bark extract of Cryptomeria japonica D. Don and to isolate potential antibacterial constituents. The results showed that the ethanolic extract of C. japonica bark possessed a good antibacterial activity. Nine compounds including seven diterpe... | 18,780,250 |
Maternal demographic and socioeconomic characteristics of live-born infants with isolated ocular congenital abnormalities. | To evaluate maternal age and birth order, in addition socioeconomic status and finally occupational background of mothers who delivered babies with different isolated ocular congenital abnormalities. The data set of the Hungarian Case-Control Surveillance of Congenital Abnormalities, 1980-2002 was used and the evaluati... | 18,780,259 |
[Poor premorbid adjustment linked to deterioration in theory of mind skills: a study in stabilised schizophrenic patients]. | Previous studies suggest that there is a deficit in theory of mind (ToM) in stabilised schizophrenic patients. More specifically, it has been claimed that poor premorbid adjustment covaries with the abnormalities in ToM skills detected in such patients. It has also been suggested that this deficit could be a trait mark... | 18,780,269 |
Architectonic subdivisions of neocortex in the gray squirrel (Sciurus carolinensis). | Squirrels are highly visual mammals with an expanded cortical visual system and a number of well-differentiated architectonic fields. To describe and delimit cortical fields, subdivisions of cortex were reconstructed from serial brain sections cut in the coronal, sagittal, or horizontal planes. Architectonic characteri... | 18,780,299 |
Parallels between the development of therapeutic drugs and cancer health disparity programs: implications for Disparities Reduction. | There are analogies between the development of therapeutic drugs for cancer and the development of interventions for reducing cancer health disparities. In both cases, it can take between 12 and 15 years for the benefits to become apparent. The initial preclinical phase of drug development is analogous to the developme... | 18,780,311 |
Receipt of guideline-recommended follow-up in older colorectal cancer survivors : a population-based analysis. | After curative resection for colorectal cancer, routine follow-up with office visits, carcinoembryonic antigen (CEA), and colonoscopy is recommended. The actual adherence to these guidelines as well as the potential overuse of testing in routine practice has not been well studied. The authors identified 9426 eligible p... | 18,780,338 |
Synthesis and characterization of semi-interpenetrating polymer networks based on polyurethane and N-isopropylacrylamide for wound dressing. | Thermosensitive semi-interpenetrating polymer networks (semi-IPNs) composed of crosslinked poly(N-isopropylacrylamide) (PNiPAAm) and linear segmented polyurethane urea (SPUU) were synthesized via thermal initiated free radical polymerization. Synthesized semi-IPNs of various compositions were characterized by Fourier t... | 18,780,359 |
Chiral HPLC separation and absolute configuration of novel S-DABO derivatives. | Chiral 2-(sec-butylthio)-6-[1-(2,6-dichlorophenyl)propyl]-5-methylpyrimidin-4(3H)-one (compound 1) was synthesized to serve as a model compound for structural elucidation of novel S-DABO (dihydroalkoxybenzyloxopyrimidine) derivatives endowed with potential HIV-1 reverse transcriptase inhibitory activity. Stereochemical... | 18,780,368 |
Breast filariasis: real-time sonographic imaging of the filarial dance. | A 50-year-old woman presented with a palpable tender nodule in the upper quadrant of the breast that was clinically thought to be a fibroadenoma, with mammographic findings of a well-defined lobulated density. Sonographic examination revealed a "filarial dance sign" within the cystic lesion, which is diagnostic of lymp... | 18,780,376 |
DNA with branched internal side chains: synthesis of 5-tripropargylamine-dU and conjugation by an azide-alkyne double click reaction. | 5-Tripropargylamine-2'-deoxyuridine (1 a) containing two terminal triple bonds was synthesized by a Pd-assisted Sonogashira cross-coupling reaction and was subsequently converted into the corresponding phosphoramidite building block (9) and employed in solid-phase oligonucleotide synthesis. T(m) experiments demonstrate... | 18,780,386 |
Reactivity of the 4-amino-5H-1,2-oxathiole-2,2-dioxide heterocyclic system: a combined experimental and theoretical study. | The reactivity of the 4-amino-5H-1,2-oxathiole-2,2-dioxide (or beta-amino-gamma-sultone) heterocyclic system has scarcely been studied. Here we describe the reactivity of this system towards electrophiles and amines on readily available model substrates differently substituted at the C-5 position. A variety of C-electr... | 18,780,390 |
In situ proteomics with imaging mass spectrometry and principal component analysis in the Scrapper-knockout mouse brain. | Imaging MS is emerging as a useful tool for proteomic analysis. We utilized this technique to analyze gene knockout (KO) mice in addition to traditional 2-DE analysis. The Scrapper-knockout (SCR-KO) mouse brain showed two types of neurodegenerative pathologies, the spongiform neurodegeneration and shrinkage of neuronal... | 18,780,397 |
Healthcare in the cross hairs. California patient-dumping investigation unwinds into billing probe, fueling enforcers' national fraud-fighting efforts. | Fraud enforcers say the FBI's raid of three Southern California hospitals last week offered new evidence that aggressive measures are needed to battle abuse. Los Angeles City Attorney Rocky Delgadillo, left, sees the case as emblematic. "Our healthcare system in America is broken--it's never been more clear to me that ... | 18,780,442 |
[Three-dimensional finite element analyses of bone surface stress of two kinds of conjunction implant]. | To establish a three-dimension finite element model of mandible with two kinds of dental implant and to study the stress of implant-bone interface. Measuring the data of the components of the dental implant and using spiral CT image reconstruction technique to scan the cross section of the mandible. Three-dimension fin... | 18,780,511 |
History of dyspepsia in Scotland. Admissions to the Edinburgh Royal Infirmary 1729-1830, doctoral theses 1726-1823, and contemporary British publications. | The aim of the study was to assess whether the rise in the occurrence of dyspepsia in Scotland during the eighteenth century was a true epidemiologic phenomenon or just an increase in medical awareness. Admissions for dyspepsia to the Edinburgh Royal Infirmary from 1729 until 1830 were analysed by consecutive five-year... | 18,780,526 |
Short-term effectiveness of a prefabricated occlusal appliance in patients with myofascial pain. | To compare the short-term effectiveness of a stabilization appliance with a prefabricated occlusal appliance in myofascial pain patients in a randomized controlled trial. Sixty-five patients at 2 centers were assigned to a stabilization appliance group (S group, n = 33) or a prefabricated appliance (Relax) group (R gro... | 18,780,534 |
The jaw functional limitation scale: development, reliability, and validity of 8-item and 20-item versions. | To develop the Jaw Functional Limitation Scale (JFLS), comprising 3 constructs and a global scale, based on a preliminary instrument, and to investigate content validity of the overall functional limitation construct, reliability, and generalizability. A temporomandibular disorders (TMD) patient group, compared to othe... | 18,780,535 |
[Ethnic origin and alveolar bone loss in Israeli adults]. | The aim of this study was to evaluate the association of alveolar bone loss and ethnic origin among Israeli adults. The study population consisted of 815 male military personnel, aged 25 to 60 years (average 38.1 +/- 7.0 yr), who arrived at a military dental clinic for routine dental examination during 2004-5. The dist... | 18,780,541 |
3D-VAS--initial results from computerized visualization of dynamic occlusion. | Visualization of the dynamic occlusion is one of the central tasks in both clinical dentistry and dental engineering. Many aspects of dynamic occlusion, such as the interocclusal function in the posterior region, cannot be seen directly clinically and at best can be recorded with contact paper. Therefore, analyses of t... | 18,780,558 |
[Urgent states in hematology: acute promyelocytic leukemia--principles of diagnosis]. | A review of diagnosis of acute promyelocytic leukemia (APL) is presented. There are still many patients with progressive disease with leukocytosis at presentation. These are at greater risk of early death due to bleeding (often intracranial), or, less frequently, due to thrombotic complications. In Czechia, we have, in... | 18,780,572 |
[Leukemogenesis and therapy of acute promyelocytic leukemia: from the worse to the most favorable subtype of acute myeloid leukemia]. | The evolution of therapy of acute promyelocytic leukemia (APL) from 1964 to present is reviewed. The paper is focused on the main findings and key studies which formed current and almost standard therapeutic approach to APL. The first important development was the use of anthracyclines for the initial therapy of APL in... | 18,780,571 |
Gender role across development in adults with 46,XY disorders of sex development including perineoscrotal hypospadias and small phallus raised male or female. | Self-rated degree of femininity and masculinity across development were evaluated for 40 adults affected by 46,XY disorders of sex development (DSDs) who presented at birth with a small phallus and perineoscrotal hypospadias, raised either male (n = 22) or female (n = 18). Most participants were confirmed or presumed t... | 18,780,596 |
[Role of retroperitoneal laparoscopic nephroureterectomy in the current treatment of upper urinary tract urothelial carcinoma]. | Nowadays, the standard treatment for upper tract transitional cell carcinoma is open nephroureterectomy, by double lumbar and iliac approach, with peri-meat bladder cuff excision. Since the first laparoscopic nephroureterectomy was performed, several surgical teams were interested by this approach for the treatment of ... | 18,780,617 |
[Development of infectious pseudo-particle harboring three subtypes hepatitis C virus glycoproteins and their application in neutralization assays]. | In this study, three expression vectors encoding unmodified glycoproteins E1 and E2 from H77 (1a), Hebei (1b) and JFH1 (2a) strains were constructed to form pVRC-H77-E1E2, pVRC-HeBei-E1E2 and pVRC-JFH1-E1E2 expressing constructs. The protein expression was confirmed by immunofluorescene assay(IFA) and Western blot. The... | 18,780,632 |
[Development and comparison of real-time and conventional RT-PCR assay for detection of human coronavirus NL63 and HKU1]. | We designed specific primers and fluorescence-labeled probes to develop real-time and conventional RT-PCR assays for detection of human coronavirus NL63 or HKU1. Subsequently, experiments were undertaken to assess diagnostic criteria such as specificity, sensitivity and reproducibility. The detection limit of the real-... | 18,780,635 |
Comparison of lipid lowering effect of sibutramine in patients treated or not treated with statins--3 month follow-up. | Older sibutramine studies showed beneficial effects on lipid profile compared to placebo. However, nowadays many obese patients are treated with lipid lowering drugs before the start of sibutramine therapy and their effects in these patients have not been investigated. Therefore we started a long-term follow up of pati... | 18,780,645 |
The values of estimated glomerular filtration rate calculated with creatinine and cystatin C based equations in healthy adults. | The glomerular filtration rate (GFR) is widely accepted as the best overall index of kidney function. GFR can be measured as the clearance of exogenous or endogenous filtration markers or clinically estimated from serum concentrations of creatinine or cystatin C. Recently, it has been recommended that an estimated GFR ... | 18,780,660 |
Ionized calcium: whole blood, plasma or serum? | To determine an optimal specimen type to be used for measurements of ionized calcium (iCa) so that it applies properly to the reference interval. Also to determine the validity of the pH correction that is applied to iCa measurements. A reference interval study of normal volunteers was performed using four sample types... | 18,780,665 |
Adjusting to personal and organisational change: views and experiences of female nurses aged 40-60 years. | The Australian nursing workforce is ageing and there is a well-documented shortage of nurses. This global phenomenon means that retaining nurses in the workforce is gaining in importance as older nurses retire and leave nursing. The existing literature reveals deficiencies in knowledge about older nurses as they adapt ... | 18,780,674 |
How to choose a mentor. | Mentors will play important roles in the careers of most successful scientists. Mentors are trusted advisors that give constructive criticism and provide information in many areas of a scientific life. Mentors will likely change throughout your career as your position changes and thus the areas of advice needed changes... | 18,780,679 |
In vivo analysis of key elements within the renin regulatory region. | Renin is responsible for initiating the enzymatic cascade that results in the production of angiotensin II, the major effector molecule of the renin-angiotensin system (RAS). Extensive information on the regulatory region of the renin gene has been derived by transient transfection studies in vitro, particularly using ... | 18,780,761 |
Study of hypothalamic leptin receptor expression in low-birth-weight piglets and effects of leptin supplementation on neonatal growth and development. | Low birth weight resulting from intrauterine growth retardation (IUGR) is a risk factor for further development of metabolic diseases. The pig appears to reproduce nearly all of the phenotypic pathological consequences of human IUGR and is likely to be more relevant than rodents in studies of neonatal development. In t... | 18,780,769 |
Contractile C2C12 myotube model for studying exercise-inducible responses in skeletal muscle. | Adequate exercise leads to a vast variety of physiological changes in skeletal muscle as well as other tissues/organs and is also responsible for maintaining healthy muscle displaying enhanced insulin-responsive glucose uptake via GLUT4 translocation. We generated highly developed contractile C(2)C(12) myotubes by mani... | 18,780,777 |
Creatine supplementation does not affect clinical health markers in football players. | To study the effects of 8-week creatine monohydrate (CrM) supplementation on blood and urinary clinical health markers in football players. 14 football players were randomly assigned in a double-blinded fashion to Cre (n = 7) or Pla (n = 7) group. The Cre group ingested 15 g/day of CrM for 7 days and 3 g/day for the re... | 18,780,799 |
Compatibility and aerosol characteristics of formoterol fumarate mixed with other nebulizing solutions. | Patients with chronic obstructive pulmonary disease (COPD) are often given admixtures of nebulizable drugs to minimize the time of administration in treatment regimens. To evaluate the physicochemical compatibility and aerodynamic characteristics of formoterol fumarate 20 microg/2 mL when mixed or sequentially nebulize... | 18,780,805 |
Pharmacology of macitentan, an orally active tissue-targeting dual endothelin receptor antagonist. | Macitentan, also called Actelion-1 or ACT-064992 [N-[5-(4-bromophenyl)-6-(2-(5-bromopyrimidin-2-yloxy)ethoxy)-pyrimidin-4-yl]-N'-propylaminosulfonamide], is a new dual ET(A)/ET(B) endothelin (ET) receptor antagonist designed for tissue targeting. Selection of macitentan was based on inhibitory potency on both ET recept... | 18,780,830 |
Tumor-penetrating microparticles for intraperitoneal therapy of ovarian cancer. | Intraperitoneal chemotherapy prolongs survival of ovarian cancer patients, but its utility is limited by treatment-related complications and inadequate drug penetration in larger tumors. Previous intraperitoneal therapy used the paclitaxel/Cremophor EL (polyethoxylated castor oil) formulation designed for intravenous u... | 18,780,831 |
CD20 up-regulation in pediatric B-cell precursor acute lymphoblastic leukemia during induction treatment: setting the stage for anti-CD20 directed immunotherapy. | CD20 is expressed in approximately one- half of pediatric acute lymphoblastic leukemia (ALL) cases with B-cell precursor (BCP) origin. We observed that it is occasionally up-regulated during treatment. To understand the impact of this on the potential effectiveness of anti-CD20 immunotherapy, we studied 237 CD10(+) ped... | 18,780,832 |
US residency training before and after the 1997 Balanced Budget Act. | Graduate medical education (GME) determines the size and characteristics of the future workforce. The 1997 Balanced Budget Act (BBA) limited Medicare funding for additional trainees in GME. There has been concern that because Medicare is the primary source of GME funding, the BBA would discourage growth in GME. To exam... | 18,780,846 |
The frequency of regulatory CD3+CD8+CD28- CD25+ T lymphocytes in human peripheral blood increases with age. | Aging is commonly associated with immune deficiency and dysregulation. The aging of the immune system involves a progressive reduction in naïve T cell output associated with thymic involution and peripheral expansion of oligoclonal memory T cells. We have investigated frequency, phenotype, and function of CD3+CD8+CD28(... | 18,780,874 |
Swing phase resistance enhances flexor muscle activity during treadmill locomotion in incomplete spinal cord injury. | This study investigated whether loading the legs during the swing phase of walking enhances flexor muscle activity in ambulatory patients with incomplete spinal cord injury (SCI). Nine patients had surface electromyography (EMG) and joint kinematics recorded from the lower extremities during treadmill walking. Swing ph... | 18,780,879 |
Motor imagery to enhance recovery after subcortical stroke: who might benefit, daily dose, and potential effects. | Motor imagery may enhance motor recovery after stroke. To estimate the proportion of patients able to perform motor imagery, the feasibility of delivery of motor imagery training (MIT), and the effects of MIT on motor recovery in an exploratory study. An immediate pretreatment and posttreatment single-group design was ... | 18,780,881 |
Accounting for health spending in developing countries. | Data on health system financing and spending, together with information on the disease prevalence and cost-effectiveness of interventions, constitute essential input into health policy. It is particularly critical in developing countries, where resources are scarce and the marginal dollar has a major impact. Yet regula... | 18,780,927 |
Aligning Forces for Quality: a program to improve health and health care in communities across the United States. | The Robert Wood Johnson Foundation's Aligning Forces for Quality program features partnerships with leaders in targeted communities. The program is working to achieve dramatic, sustainable improvements in quality across the continuum of care by 2015. These improvements will affect patients of all races and ethnicities. | 18,780,937 |
The effects of cured dentin bonding agents on secretion of pro-inflammatory cytokines, IL-1beta and TNF-alpha, by human monocytes. | Dentin Bonding Agents (DBA) have been used as root-end filling materials. Present study evaluated the effects of polymerized DBA on secretion of pro-inflammatory cytokines by normal human monocytes. In this study, monocytes were directly isolated from human peripheral blood, and exposed to cured Scotch Bond 1 (single b... | 18,780,953 |
Adaptive fractionation therapy: II. Biological effective dose. | Radiation therapy is fractionized to differentiate the cell killing between the tumor and organ at risk (OAR). Conventionally, fractionation is done by dividing the total dose into equal fraction sizes. However, as the relative positions (configurations) between OAR and the tumor vary from fractions to fractions, intui... | 18,780,956 |
High-speed evaluation of track-structure Monte Carlo electron transport simulations. | There are many instances where Monte Carlo simulation using the track-structure method for electron transport is necessary for the accurate analytical computation and estimation of dose and other tally data. Because of the large electron interaction cross-sections and highly anisotropic scattering behavior, the track-s... | 18,780,958 |
Management of synchronized network activity by highly active neurons. | Increasing evidence supports the idea that spontaneous brain activity may have an important functional role. Cultured neuronal networks provide a suitable model system to search for the mechanisms by which neuronal spontaneous activity is maintained and regulated. This activity is marked by synchronized bursting events... | 18,780,962 |
Effects of sildenafil on nigrostriatal dopamine neurons in a murine model of Parkinson's disease. | The objective of this study was to determine if the phosphodiesterase 5 (PDE-5) inhibitor, sildenafil, could be used as a neuroprotective agent in a chronic 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine (MPTP) murine model of Parkinson's disease. The underlying hypothesis of these studies is that blockade of PDE-5 catab... | 18,780,970 |
Differential changes in synaptic proteins in the Alzheimer frontal cortex with marked increase in PSD-95 postsynaptic protein. | We investigated how synaptic plasticity is related to the neurodegeneration process in the human dorsolateral prefrontal cortex. Pre- and postsynaptic proteins of Brodmann's area 9 from patients with Alzheimer's disease (AD) and age-matched controls were quantified by immunohistochemical methods and Western blots. The ... | 18,780,974 |
A comparison of selected isokinetic trunk strength parameters of elite male judo competitors and cyclists. | Each sporting activity appears to require some distinctive motor functions. The purpose of this study was to establish referential isokinetic strength parameters in competitive judo athletes because no previous studies have examined trunk strength of judo athletes isokinetically and to test the hypothesis that the isok... | 18,780,991 |
Current concepts in the treatment of anterior cruciate ligament disruption. | Treatment of anterior cruciate ligament injuries has changed considerably in recent years. The purpose of this paper is to discuss the past and present treatment for anterior cruciate ligament (ACL) disruptions in athletic individuals. In addition, this paper will discuss current trends in rehabilitation, such as immed... | 18,781,001 |
The Editor's Role in the Science and Art of Physical Therapy. | James A. Gould, MS, PT, delivered the Paris Distinguished Service Award Lecture at the Combined Sections meeting in San Francisco in February. Gould is the second recipient of the Orthopaedic Section's Paris Award, which was named for its first recipient and the founder of the Orthopaedic Section, Stanley Paris, PhD, P... | 18,781,005 |
Ion exchange and protonation equilibria of an amphoteric ion-exchange resin in the presence of simple salt. | The influence of simple salts on the ion exchange and protonation equilibria of an amphoteric ion-exchange resin, which has strong base and weak acid moieties in a single functional group fixed onto the styrene-DVB matrix, has been investigated. Concentrations of ionic species in the amphoteric ion-exchange resin in eq... | 18,781,023 |
Determination of psoralen in human plasma using excitation-emission matrix fluorescence coupled to second-order calibration. | A new algorithm, an alternating normalization-weighted error (ANWE) method, and the parallel factor analysis (PARAFAC) have been used to directly determine psoralen (PSO) in human plasma. The two methods fully exploit the second-order advantage of the applied three-way fluorescence data. Interestingly, the calibration ... | 18,781,031 |
Folic acid prevents congenital malformations in the offspring of diabetic mice. | It is well known that maternal diabetes causes various congenital malformations. Although there are many reports that folic acid (FA) administration in pregnancy reduces the risk of birth defects including neural tube defects (NTDs), a precise analysis on the preventive effect of FA against diabetic embryopathy has not... | 18,781,038 |
Rat gastric banding model for bariatric surgery. | Adjustable gastric banding is a surgical approach to weight reduction. In this study we created a gastric banding model in rats to better understand the mechanism of body weight loss. Male Sprague-Dawley rats weighing 260 to 280 g were subjected to gastric banding (band group) (n=8) or to a sham operation (control grou... | 18,781,041 |
The excellent water-solubility of N-[3-(dimethyl-amino)propyl] docosanamide chloride : the most eco-friendly cationic hair conditioning agent. | A new hair-conditioning agent, N-[3-(dimethylamino)propyl]docosanamide (APA-22) hydrochloric acid salt (APA-22 HCl), has excellent solubility in water with a solubility limit over 10-times larger than that of other APA hydrochloric salts with shorter alkyl chain lengths. The physicochemical characteristics of APA-22 HC... | 18,781,052 |
Effect of starch and sucrose on dental biofilm formation and on root dentine demineralization. | The cariogenicity of starch alone or in combination with sucrose is controversial and the effect on dentine demineralization and on the dental biofilm formed has not been explored under controlled conditions. A crossover, single-blind study was conducted in four steps of 14 days each, during which 11 volunteers wore pa... | 18,781,066 |
Calcium pre-rinse greatly increases overnight salivary fluoride after a 228 ppm fluoride rinse. | Large increases in salivary fluoride were reported 1 h after a calcium pre-rinse/NaF rinse. This study examined the persistence of these increases. 12 subjects rinsed in the evening with water, with a 228 microg/g (ppm) F rinse or with 150 mmol/l calcium lactate followed by a 228 microg/g F rinse. In a second experimen... | 18,781,069 |
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