title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Transumbilical single-port laparoscopic partial nephrectomy. | To present the initial experience with laparoscopic partial nephrectomy (LPN) performed through a transumbilical single port. Between November 2007 and April 2008, five selected patients underwent single-port LPN (SPLPN) for renal tumours. All procedures were performed through a single intraumbilical multichannel lapar... | 18,778,351 |
A RNA transcript (Heg) in mononuclear cells is negatively correlated with CD14 mRNA and TSH receptor autoantibodies. | During a study of gene expression of foxp3 in blood mononuclear cells we observed a DNA product of an unknown RNA fragment. The area of this peak correlated with CD14 mRNA in a small group of subjects. The sequence was localized to chromosome 1. We tested the hypothesis that gene expression of the poly A(-) transcript ... | 18,778,364 |
Impaired immune responses in streptozotocin-induced type I diabetes in mice. Involvement of high glucose. | Diabetes is widely believed to predispose to serious infections. However, the mechanisms linking diabetes and immunosuppression are not well defined. One potential mediator of the altered defence mechanisms is hyperglycaemia. It has been identified as the main factor contributing to the development of diseases associat... | 18,778,365 |
Deliberate practice and acquisition of expert performance: a general overview. | Traditionally, professional expertise has been judged by length of experience, reputation, and perceived mastery of knowledge and skill. Unfortunately, recent research demonstrates only a weak relationship between these indicators of expertise and actual, observed performance. In fact, observed performance does not nec... | 18,778,378 |
The waterpipe: time for action. | The waterpipe, known in many cultures under different shapes and names (e.g. hookah, shisha, narghile), is a centuries-old tobacco use method that is witnessing a world-wide surge in popularity. This popularity is most noticeable among youths, and is surpassing cigarette smoking among this group in some societies. Many... | 18,778,388 |
Hypothyroidism is associated with signs of endothelial dysfunction despite 1-year replacement therapy with levothyroxine. | Hypothyroidism is associated with elevated cardiovascular risk, not fully explained by classical risk factors. Instead, endothelial dysfunction may link hypothyroidism to atherosclerosis. The effect of levothyroxine substitution on endothelial function has been sparsely studied and the results are unclear. This study t... | 18,778,398 |
Reduced expression of the vesicular acetylcholine transporter causes learning deficits in mice. | Storage of acetylcholine in synaptic vesicles plays a key role in maintaining cholinergic function. Here we used mice with a targeted mutation in the vesicular acetylcholine transporter (VAChT) gene that reduces transporter expression by 40% to investigate cognitive processing under conditions of VAChT deficiency. Moto... | 18,778,400 |
Effect of a family psychoeducational program on relatives of schizophrenia patients. | Family psychoeducational programs have been shown to be effective in terms of knowledge acquirement and relapse prevention, but few studies have looked at whether one mode of educational method is more effective than another. The aim of the present study was to compare several modes of educational approaches and to elu... | 18,778,434 |
Relationship between exploratory eye movement, P300, and reaction time in schizophrenia. | Exploratory eye movement (EEM), P300 and reaction time (RT) tests may relate to the important parts of information processing in the human brain. Therefore the aim of the present study was to compare EEM, P300 and RT test data in schizophrenic and normal control groups to investigate whether schizophrenic patients have... | 18,778,436 |
Predictors of subjective and objective quality of life in outpatients with schizophrenia. | In recent years, greater attention has been given to quality of life (QOL) in schizophrenia and several studies reported that negative and depressive symptoms and cognitive dysfunction are related to patient QOL. But because a variety of QOL measures have been used in the previous studies, there seems to be no unanimou... | 18,778,437 |
Relationship of attention-deficit-hyperactivity disorder symptoms, depressive/anxiety symptoms, and life quality in young men. | Attention-deficit-hyperactivity disorder (ADHD) continues to be among the most frequently missed of psychiatric diagnoses in adults because its presentation in adulthood so often mimics those of better-known disorders. The aim of the present study was to examine the relationship between ADHD symptoms, depression/anxiet... | 18,778,439 |
Restless legs symptoms with sleepiness in relation to mortality: 20-year follow-up study of a middle-aged Swedish population. | The aim of the present study was to investigate restless legs symptoms with concomitant daytime sleepiness as a risk factor for mortality in a middle-aged population. A cohort of 5102 subjects aged 30-65 years in mid-Sweden who responded to a postal questionnaire in 1983 was followed up. The questionnaire included ques... | 18,778,444 |
Dynamics of positional warfare malaria: Finland and Korea compared. | A sudden outbreak of vivax malaria among Finnish troops in SE-Finland and along the front line in Hanko peninsula in the southwest occurred in 1941 during World War II. The common explanation has been an invasion of infective Anopheles mosquitoes from the Russian troops crossing the front line between Finland and Sovie... | 18,778,473 |
Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival. | We have engaged in an international program designated the Bank On A Cure, which has established DNA banks from multiple cooperative and institutional clinical trials, and a platform for examining the association of genetic variations with disease risk and outcomes in multiple myeloma. We describe the development and c... | 18,778,477 |
Gene expression variation to predict 10-year survival in lymph-node-negative breast cancer. | It is of great significance to find better markers to correctly distinguish between high-risk and low-risk breast cancer patients since the majority of breast cancer cases are at present being overtreated. 46 tumours from node-negative breast cancer patients were studied with gene expression microarrays. A t-test was c... | 18,778,486 |
Association between obesity indices and blood pressure or hypertension: which index is the best? | The association between obesity and blood pressure is well documented and a series of obesity indices are used as risk factors or indicators of blood pressure and/or the presence of hypertension. The aim of the present study was to explore and determine which obesity index is the best indicator of blood pressure and th... | 18,778,533 |
[Surgeon's role in diabetic retinopathy]. | Diabetic retinopathy (DR) is the most frequent cause of blindness during the patient's economically active years. The probability of developing this disease increases with the number of diabetic patients in our country, as well as their survival. In general, DR progression is predictable, from minimum changes (barely d... | 18,778,535 |
A review of intensity-modulated radiation therapy. | Intensity-modulated radiation therapy (IMRT) is a sophisticated form of three-dimensional treatment planning and delivery. In some situations, IMRT allows more conformal radiation therapy to complex targets within the lung. As problems related to organ motion are increasingly addressed, the use of IMRT in the treatment... | 18,778,554 |
Insights from experimental studies into allodynia and its treatment. | Migraine is a common disorder that often is accompanied by cutaneous allodynia. Cutaneous allodynia on the head has been linked to sensitization of neurons in the trigeminal nucleus caudalis in animal models of migraine. In addition, migraine with allodynia is refractory to acute treatment with triptans. Understanding ... | 18,778,578 |
The Why WAIT program: improving clinical outcomes through weight management in type 2 diabetes. | Targeting body weight, as an alternative model to targeting hemoglobin A(1c), is emerging as a viable and potentially cost-effective approach to diabetes management in clinical practice. Why WAIT (Weight Achievement and Intensive Treatment) is a 12-week multidisciplinary program for weight control and intensive diabete... | 18,778,592 |
Ultrasonographic examination of the deltoid ligament in bimalleolar equivalent fractures. | Lauge-Hansen supination-external rotation Stage IV ankle injuries may simulate a Stage II or Stage III injury radiographically if the medial disruption occurred through the deltoid ligament instead of the medial malleolus, making it difficult to determine whether an operation is indicated. Seventeen patients presented ... | 18,778,665 |
Effect of glycyrrhetinic acid on membrane band 3 in human erythrocytes. | Glycyrrhetinic acid (GA) is a hydrolytic product of the triterpene glycoside of glycyrrhizic acid, one of the main constituents of licorice root, which has long been studied, due to its several biological and endocrine properties. In this paper, GA was tested on human erythrocytes, and GA-induced alterations were compa... | 18,778,682 |
Oleanolic acid derivative NPLC441 potently stimulates glucose transport in 3T3-L1 adipocytes via a multi-target mechanism. | The natural product oleanolic acid (OA) has been discovered to exhibit varied pharmacological functions including anti-inflammation, anti-tumor and anti-diabetes, while appropriate synthetic oleanolic acid derivatives seem to possess more potent activities. Here we identified a new oleanolic acid derivative, 3-beta-(2-... | 18,778,688 |
Membrane disruption: an early event of hair cell apoptosis induced by exposure to intense noise. | Membrane leakage has been found in hair cells undergoing apoptosis following exposure to intense noise. However, it is not known whether this membrane damage is the consequence of apoptotic degeneration or direct mechanical stress. The current study was designed to investigate whether membrane damage occurred before th... | 18,778,691 |
Transcriptional and epigenetic regulations of embryonic stem cells. | Embryonic stem cells (ESCs) are characterized by their broad developmental potential and the capacity to self-renew. The advent of high-throughput technologies has facilitated genome-wide studies of transcriptional network, resulting in an ever-increasing repertoire of transcription factors implicated in the maintenanc... | 18,778,721 |
Four different integrative recombination events involved in the mobilization of the gonococcal 5.2 kb beta-lactamase plasmid pSJ5.2 in Escherichia coli. | We identified and characterized four different recombination mechanisms involved in the cointegrative transfer of the Neisseria gonorrhoeae beta-lactamase plasmid pSJ5.2 by the gonococcal 41 kb tet(M) and the Gram negative self-transmissible plasmids N3 and R64 drd-33 using an Escherichia colirecA-background. Mobilizat... | 18,778,732 |
Involvement of striatal lipid peroxidation and inhibition of calcium influx into brain slices in neurobehavioral alterations in a rat model of short-term oral exposure to manganese. | Manganese is an essential element for biological systems, nevertheless occupational exposure to high levels of Mn can lead to neurodegenerative disorder, characterized by excessive Mn accumulation, especially in astrocytes of basal ganglia and symptoms closely resembling idiopathic Parkinson's disease (PD). The purpose... | 18,778,733 |
The effect of suppressing negative emotions on eating behavior in binge eating disorder. | Overeating may be a consequence of the suppression of negative emotions, by depleting self-control resources. This experiment investigated whether (a) there is a causal relationship between the suppression of negative emotions, negative mood, and overeating in people with binge eating disorder (BED) and whether (b) thi... | 18,778,742 |
Cannabinoid receptor 2 is increased in acutely and chronically inflamed bladder of rats. | Cannabinoid receptors 1 and 2 (CB1 and CB2) are G-protein coupled receptors that are expressed throughout the body. Cannabinoid receptors are expressed in the urinary bladder and may affect bladder function. The purpose of this study was twofold: to confirm the presence of cannabinoid receptors in the bladder, the L6/S... | 18,778,751 |
The effect of intra-arterial papaverine on ECoG activity in the ketamine anesthetized rat. | The opium alkaloid papaverine (PPV) causes vasodilatation of the cerebral arteries through direct action on smooth muscle that reduces the constriction of smooth muscle. Intra-arterial papaverine (IAP) has been used widely to increase the regional cerebral blood flow in order to reverse the cerebral vasospasm that occu... | 18,778,752 |
Investigation of the carbopol gel of solid lipid nanoparticles for the transdermal iontophoretic delivery of triamcinolone acetonide acetate. | The purpose of this study was to investigate solid lipid nanoparticles (SLN) hydrogel for transdermal iontophoretic drug delivery. Triamcinolone acetonide acetate (TAA), a glucocorticoids compound, was employed as the model drug. SLN containing the drug triamcinolone acetonide acetate (TAA-SLN) and their carbopol gel w... | 18,778,760 |
Central effects of isolated fractions from the root of Petiveria alliacea L. (tipi) in mice. | Petiveria alliacea L. (tipi) a shrub from Phytolaccaceae family is popularly used in folk medicine for treating a wide variety of disorders in South and Central America. To investigate the neuropharmacological properties on experimental animals. The acetate (FA), hexanic (FH), hydroalcoholic (FHA) and precipitated hydr... | 18,778,763 |
Application of high pressure laser flash photolysis in studies on selected hemoprotein reactions. | This article focuses on the application of high pressure laser flash photolysis for studies on selected hemoprotein reactions with the objective to establish details of the underlying reaction mechanisms. In this context, particular attention is given to the reactions of small molecules such as dioxygen, carbon monoxid... | 18,778,796 |
Risk factors of liver dysfunction after extended hepatic resection in biliary tract malignancies. | Postoperative hepatic insufficiency is a critical complication after extended hepatic resection in patients with biliary tract malignancies, the majority of whom suffer from obstructive jaundice. The aim of this study was to assess clinical parameters linked to this type of liver dysfunction. A total of 111 patients we... | 18,778,802 |
Efficacy of diagnostic upper-node procedures during laryngectomy for glottic carcinoma. | Regional recurrence of glottic squamous cell carcinoma was evaluated in patients with a clinically N0 neck who underwent selective upper-node dissection (SUND) or selective upper-node inspection (SUNI; surgical visualization and palpation of jugular lymph nodes at levels II and III) during (salvage) laryngectomy. In 15... | 18,778,803 |
Life-threatening postoperative pancreatic fistula (grade C) after pancreaticoduodenectomy: incidence, prognosis, and risk factors. | Pancreatic fistula (PF) is one of the most common postoperative complications of pancreatoduodenectomy (PD). A recent International Study Group on Pancreatic Fistula (ISGPF) definition grades the severity of PF according to the clinical impact on the patient's hospital course. Although PF is generally treated conservat... | 18,778,804 |
Does the duration of surgery affect outcomes in patients undergoing coronary artery bypass grafting? | Numerous predictors of coronary artery bypass grafting (CABG) outcomes have been identified. We aimed to determine whether the duration of surgery independently predicts outcome in patients undergoing CABG. We retrospectively reviewed data from 337 patients (mean age 62 +/- 7 years) who underwent CABG consecutively at ... | 18,778,805 |
Effect of tamoxifen treatment on global and insulin-like growth factor 2-H19 locus-specific DNA methylation in rat spermatozoa and its association with embryo loss. | To determine the effect of tamoxifen treatment on global and insulin-like growth factor 2-H19 imprinting control region (Igf2-H19 ICR)-specific DNA methylation in rat spermatozoa and analyze its association with postimplantation loss. Experimental prospective study. Animal research and academic research facility. Male ... | 18,778,817 |
Serum levels of soluble vascular cell adhesion molecule-1, tumor necrosis factor-alpha, and interleukin-6 in in vitro fertilization cycles. | To assess whether gonadotropin-induced changes in E(2) alter serum levels of soluble vascular cell adhesion molecule-1 (sVCAM-1) and proinflammatory cytokines. Prospective collection of serum in patients undergoing IVF. University hospital. Twenty-four infertile women. Serum collection at baseline, in the mid and late ... | 18,778,820 |
Simultaneous characterization of selenium and arsenic analytes via ion-pairing reversed phase chromatography with inductively coupled plasma and electrospray ionization ion trap mass spectrometry for detection applications to river water, plant extract and urine matrices. | With an increased awareness and concern for varying toxicities of the different chemical forms of environmental contaminants such as selenium and arsenic, effective methodologies for speciation are paramount. In general, chromatographic methodologies have been developed using a particular detection system and a unique ... | 18,778,826 |
Optimisation of asymmetrical flow field flow fractionation for environmental nanoparticles separation. | The fractionation of natural nanoparticles by Asymmetrical Flow Field Flow Fractionation (As-Fl-FFF) was optimised by considering the following operating conditions: ionic strength, surfactant concentration and crossflow rate. The method performances such as fractionation recovery and fractionation efficiency were eval... | 18,778,831 |
Strategies for monitoring the emerging polar organic contaminants in water with emphasis on integrative passive sampling. | Although polar organic contaminants (POCs) such as pharmaceuticals are considered as some of today's most emerging contaminants few of them are regulated or included in on-going monitoring programs. However, the growing concern among the public and researchers together with the new legislature within the European Union... | 18,778,833 |
Sleep problems and suicidality in the National Comorbidity Survey Replication. | Links between sleep problems and suicidality have been frequently described in clinical samples; however, this issue has not been well-studied in the general population. Using data from a nationally representative survey, we examined the association between self-reported sleep difficulties and suicidality in the United... | 18,778,837 |
Optimization of nutrient component for diesel oil degradation by Rhodococcus erythropolis. | A novel bacterium T7-2 was isolated from the oil-polluted sea-bed mud of Bohai Sea, northern China, which can degrade diesel oil at 15 degrees C. This bacterium was identified as a strain of Rhodococcus erythropolis according to its 16S rDNA gene. In order to enhance degradation efficiency, a five-level, three-factor c... | 18,778,839 |
The genetic diversity of human noroviruses detected in river water in Korea. | We studied the genetic diversity of human noroviruses in river waters by RT-nested PCR and phylogenetic analysis. During 2002-2003, water samples were collected from four rivers in Gyeonggi Province, South Korea. Among the 58 samples, 32 (55.2%) and 26 (44.8%) showed positive results with noroviruses belonging to genog... | 18,778,846 |
Relationships among specific reasons for culling, reproductive data, and gross morphology of the genital tracts in gilts culled due to reproductive failure in Thailand. | The present study aims to investigate genital organs of replacement gilts culled due to reproductive failure, and the relationship between gross morphological findings and historical reproductive data. The study was conducted from July 2005 to September 2006 and included a random sample of 200 genital organs from six s... | 18,778,851 |
Physicians' multitasking and incentives: empirical evidence from a natural experiment. | We analyse how physicians respond to contractual changes and incentives within a multitasking environment. In 1999 the Quebec government (Canada) introduced an optional mixed compensation (MC) system, combining a fixed per diem with a partial (relative to the traditional fee-for-service (FFS) system) fee for services p... | 18,778,862 |
Changes in leaf water relations, gas exchange, growth and flowering quality in potted geranium plants irrigated with different water regimes. | Geranium plants are an important part of urban green areas but suffer from drought, especially when grown in containers with a limited volume of medium. In this experiment, we examined the response of potted geraniums to different irrigation levels. Geranium (Pelargoniumxhortorum L.) seedlings were grown in a growth ch... | 18,778,872 |
Changes in the protein profile of Quercus ilex leaves in response to drought stress and recovery. | To characterize the molecular response of holm oak to drought stress and its capacity to recover 9-month-old Quercus ilex seedlings were subjected to three treatments for a 14-d period: (i) continuous watering to field capacity (control plants, W), (ii) no irrigation (drought treatment, D), and (iii) no irrigation for ... | 18,778,874 |
Immucillins in custom catalytic-site cavities. | Neighboring-group participation in the reaction catalyzed by purine nucleoside phosphorylase involves a compression mode between the 5'- and 4'-ribosyl oxygens, facilitated by His257. The His257Gly mutant opens a space in the catalytic site. Hydrophobic 5'-substituted Immucillins are transition-state analogue inhibitor... | 18,778,937 |
Tuberous sclerosis: localizing the epileptogenic tuber with synthetic aperture magnetometry with excess kurtosis analysis. | The hallmark of tuberous sclerosis is the presence of multiple cortical tubers. Identifying the epileptogenic tubers is difficult and often requires invasive intracranial electroencephalograph (EEG) monitoring. We report on a patient with tuberous sclerosis upon whom the novel magnetoencephalography (MEG) technique of ... | 18,778,940 |
Endoscopic management of pancreatic pseudocyst in children-a long-term follow-up. | Literature on long-term outcome after endoscopic management of pediatric pancreatic pseudocyst is not available. The aim of the present study is to report long-term outcome after endoscopic drainage of pancreatic pseudocyst in children. Nine patients younger than 15 years, subjected to endoscopic pseudocyst drainage, w... | 18,778,998 |
Cervical spine injury in young children: a National Trauma Data Bank review. | Blunt cervical spine injury (CSI) is rare in the pediatric population. The objective of this study was to better characterize the incidence and type of CSI in young children (age <3 years) using a large, trauma center-based data set. The National Trauma Data Bank (NTDB) was reviewed for the period January 2001 to De... | 18,779,013 |
Active for life: final results from the translation of two physical activity programs. | Most evidence-based programs are never translated into community settings and thus never make a public health impact. Active for Life (AFL) was a 4-year translational initiative using a pre-post, quasi-experimental design. Data were collected from 2003 to 2007. Analyses were conducted in 2005 and 2008. Nine lead organi... | 18,779,028 |
A novel technique for distal locking of intramedullary nail based on two non-constrained fluoroscopic images and navigation. | Distal locking is one of the most difficult steps in intramedullary nailing. Numerous methods can help the surgeon, but all are time-consuming and involve much irradiation. We have developed and tested a new method based on only two fluoroscopic shots that do not need to be taken in the axes of the holes. This avoids r... | 18,779,062 |
Sparsity-enforced slice-selective MRI RF excitation pulse design. | We introduce a novel algorithm for the design of fast slice-selective spatially-tailored magnetic resonance imaging (MRI) excitation pulses. This method, based on sparse approximation theory, uses a second-order cone optimization to place and modulate a small number of slice-selective sinc-like radio-frequency (RF) pul... | 18,779,063 |
Continuous and discrete data rebinning in time-of-flight PET. | This paper investigates data compression methods for time-of-flight (TOF) positron emission tomography (PET), which rebin the 3-D TOF measurements into a set of 2-D TOF data for a stack of transaxial slices. The goal of this work is to develop rebinning algorithms that are more accurate than the TOF single-slice-rebinn... | 18,779,067 |
A healthcare integration system for disease assessment and safety monitoring of dementia patients. | Elderly dementia patients often get lost due to lack of a sense of direction. This may put them at risk and cause their families much worry. The goal of this study is to use information technology to enhance the professional judgment of caregivers, strengthen internal safety monitoring at care organizations, and improv... | 18,779,072 |
A generic framework for internet-based interactive applications of high-resolution 3-D medical image data. | With the advances in medical imaging devices, large volumes of high-resolution 3-D medical image data have been produced. These high-resolution 3-D data are very large in size, and severely stress storage systems and networks. Most existing Internet-based 3-D medical image interactive applications therefore deal with o... | 18,779,076 |
The effects of cell sizes, environmental conditions, and growth phases on the strength of individual W303 yeast cells inside ESEM. | We performed in situ measurements of mechanical properties of individual W303 wild-type yeast cells by using an integrated environmental scanning electron microscope (ESEM)-nanomanipulator system. Compression experiments to penetrate the cell walls of single cells of different cell sizes (about 3-6 micro m diameter), e... | 18,779,098 |
[Advance in human free circulating DNA]. | Free circulating DNA is one kind of extracellular free DNA, which was examined in the zoology, botany and the human's body fluid. The detection of free circulating DNA had already been applied in monitoring the disease, embryo's pre-natal diagnosis, tumor research. This article reviewed some biology characteristics of ... | 18,779,122 |
[Genetic diversity of Mongolian gerbils (Meriones unguiculatus)]. | Genetic diversity of Z:ZCLA Mongolian gerbils, wild Mongolian gerbils and 3 inbred M. gerbil strains was evaluated with 17 microsatellite loci. The genetic variabilities within and between populations were estimated. The results showed that 9 microsatellite DNA, AF200940, AF200941, AF200942, AF200945, AF200946, AF20094... | 18,779,131 |
[Genetic effects of MC4R and POU1F1 gene on the growth performance in Jinghai yellow chicken]. | Melanocortin-4 receptor (MC4R) gene and pituitary specific transcription factor 1 (POU1F1) gene were studied as candidate genes on the Jinghai yellow chicken in this study. Polymorphisms of MC4R and POU1F1 gene had been analyzed by PCR-SSCP and DNA sequencing method. The relationship between two candidate genes and the... | 18,779,134 |
[Polymorphisms of mitochondrial Cyt b gene and D-loop region in sweetfish (Plecoglossus altivelis Temminck et Schlegel) from Zhejiang and Fujian Provinces]. | We reported here the molecular analysis of mitochondrial genomes in sweetfish (Plecoglossus altivelis). Thirty-one specimens were recruited from Ruian, Zhejiang Province, Ningde, Fujian Province, and Dongzhang reservoir, Fujian Province. DNA segments spanning cytochrome b gene and D-loop region derived from these speci... | 18,779,137 |
[Development and application of EST-derived SSR markers for bananas (Musa nana Lour.)]. | A total of 2,284 banana unigene sequences were mined, resulting in the identification of 122 SSRs in 110 sequences. Among them, there were 37 motifs the overall average length of SSRs was 20 bp. The trinucleotide repeats appeared to be the most abundant SSRs (47.6%), followed by dinucleotide repeats (33.1%), whereas th... | 18,779,139 |
[A girl with partial monosomy 18q21: cytogenetic and molecular genetics studies]. | This study is about a girl with chromosome deletion of 18q and with mental retardation and mild delay of physical development. Based on karyotyping of high resolution, fluorescence in situ hybridization (FISH) and microsatellite analysis mapping to 18q, we found that the patient's karyotype was interpreted as 46,XX,del... | 18,779,147 |
[Mapping of the yellow inhibitor gene I in silkworm Bombyx mori using SSR markers]. | The yellow color of silkworm (Bombyx mori) cocoon is mainly controlled by three genes, Y (yellow blood), I (yellow inhibitor) and C (out-layer yellow cocoon) genes. I gene locates on the 9th chromosome of silkworm and prevents the transport of carotenoid from epithelia of midgut into hemolymph. Owning to a lack of cros... | 18,779,155 |
[The study on inhabiting endothelial cell aging by targeted silencing of p22phox]. | The aim of the study was to determine the importance and possible mechanism of NAD (P)H oxidase subunits P (superscript 22phox) involved in human umbilical endothelial cell lines ECV-304 aging by special short interference RNA (siRNA). Three siRNAs targeting p22phox were designed and synthesized in vitro, which were us... | 18,779,176 |
[Integrating genetic and gene expression data: methods and applications of eQTL mapping]. | The availability of high-throughput genotyping technologies and microarray assays has allowed researchers to investigate genetic variations that influence levels of gene expression. Expression Quantitative Trait Locus (eQTL) mapping methods have been used to identify the genetic basis of gene expression. Similar to tra... | 18,779,184 |
Diagnosis and management of work-related asthma: American College Of Chest Physicians Consensus Statement. | A previous American College of Chest Physicians Consensus Statement on asthma in the workplace was published in 1995. The current Consensus Statement updates the previous one based on additional research that has been published since then, including findings relevant to preventive measures and work-exacerbated asthma (... | 18,779,187 |
Surfactant protein D and bronchial dysplasia in smokers at high risk of lung cancer. | Surfactant dysfunction has been implicated in both lung cancer and COPD. This study evaluated the relationship between surfactant protein D (SP-D) and the progression of bronchial dysplasia in heavy smokers. SP-D and oxidized glutathione levels were determined in samples of BAL fluid from 71 ex-smokers and current heav... | 18,779,194 |
Dementia prevention: methodological explanations for inconsistent results. | The prevention of neurodegenerative dementias, such as Alzheimer disease, is a growing public health concern, because of a lack of effective curative treatment options and a rising global prevalence. Various potential risk or preventive factors have been suggested by epidemiologic research, including modifiable lifesty... | 18,779,228 |
Continuous glucose monitoring and intensive treatment of type 1 diabetes. | The value of continuous glucose monitoring in the management of type 1 diabetes mellitus has not been determined. In a multicenter clinical trial, we randomly assigned 322 adults and children who were already receiving intensive therapy for type 1 diabetes to a group with continuous glucose monitoring or to a control g... | 18,779,236 |
UK epidemic Escherichia coli strains A-E, with CTX-M-15 beta-lactamase, all belong to the international O25:H4-ST131 clone. | Uropathogenic and invasive Escherichia coli O25:H4-ST131 isolates producing CTX-M-15 extended-spectrum beta-lactamase (ESBL) enzymes have recently been shown to be disseminated across the globe. In the UK, many CTX-M-15 ESBL-producing E. coli strains have been previously defined as belonging to the epidemic strains A-E... | 18,779,256 |
Association between non-subcutaneous adiposity and calcified coronary plaque: a substudy of the Multi-Ethnic Study of Atherosclerosis. | Excessive non-subcutaneous fat deposition may impair the functions of surrounding tissues and organs through the release of inflammatory cytokines and free fatty acids. We examined the cross-sectional association between non-subcutaneous adiposity and calcified coronary plaque, a noninvasive measure of coronary artery ... | 18,779,279 |
Present situation of biomarkers for copper status. | Serum or plasma copper and ceruloplasmin concentrations are the most widely used laboratory indicators to evaluate copper status. Both indicators are decreased in moderate or severe copper deficiency. The activity of several cuproenzymes is decreased in mild copper deficiency. However, their use is limited by the nonex... | 18,779,309 |
The ING4 tumor suppressor attenuates NF-kappaB activity at the promoters of target genes. | The NF-kappaB family mediates immune and inflammatory responses. In many cancers, NF-kappaB is constitutively activated and induces the expression of genes that facilitate tumorigenesis. ING4 is a tumor suppressor that is absent or mutated in several cancers. Herein, we demonstrate that in human gliomas, NF-kappaB is c... | 18,779,315 |
Paradoxical effect of mitochondrial respiratory chain impairment on insulin signaling and glucose transport in adipose cells. | Adipocyte function is crucial for the control of whole body energy homeostasis. Pathway analysis of differentiating 3T3-L1 adipocytes reveals that major metabolic pathways induced during differentiation involve mitochondrial function. However, it is not clear why differentiated white adipocytes require enhanced respira... | 18,779,333 |
Recruitment of Rab27a to phagosomes controls microbial antigen cross-presentation by dendritic cells. | Polyreactive immunoglobulins (Ig) and complement components are present in tissues and blood of healthy individuals. They facilitate pathogen uptake and inactivation in lysosomes of phagocytes and thereby provide rapid protection against infection. Dendritic cells (DCs) are phagocytes that can acquire peptides from pha... | 18,779,337 |
Functional characterization and novel rickettsiostatic effects of a Kunitz-type serine protease inhibitor from the tick Dermacentor variabilis. | Here we report the novel bacteriostatic function of a five-domain Kunitz-type serine protease inhibitor (KPI) from the tick Dermacentor variabilis. As ticks feed, they release anticoagulants, anti-inflammatory and immunosuppressive molecules that mediate the formation of the feeding lesion on the mammalian host. A numb... | 18,779,339 |
Efficacy of the combination of tachyplesin III and clarithromycin in rat models of Escherichia coli sepsis. | We investigated the efficacy of tachyplesin III and clarithromycin in two experimental rat models of severe gram-negative bacterial infections. Adult male Wistar rats were given either (i) an intraperitoneal injection of 1 mg/kg Escherichia coli 0111:B4 lipopolysaccharide or (ii) 2 x 10(10) CFU of E. coli ATCC 25922. F... | 18,779,356 |
The mouth of a dense-core vesicle opens and closes in a concerted action regulated by calcium and amphiphysin. | Secretion of hormones and peptides by neuroendocrine cells occurs through fast and slow modes of vesicle fusion but the mechanics of these processes are not understood. We used interference reflection microscopy to monitor deformations of the membrane surface and found that both modes of fusion involve the tightly coup... | 18,779,374 |
Time-dependent block of ultrarapid-delayed rectifier K+ currents by aconitine, a potent cardiotoxin, in heart-derived H9c2 myoblasts and in neonatal rat ventricular myocytes. | Aconitine (ACO), a highly toxic diterpenoid alkaloid, is recognized to have effects on cardiac voltage-gated Na(+) channels. However, it remains unknown whether it has any effects on K(+) currents. The effects of ACO on ion currents in differentiated clonal cardiac (H9c2) cells and in cultured neonatal rat ventricular ... | 18,779,382 |
The protein and the gene encoding the receptor for the cellular uptake of transcobalamin-bound cobalamin. | The transcobalamin (TC, TCII) receptor (TCblR) on the plasma membrane binds TC- cobalamin (Cbl) and internalizes the complex by endocytosis. This receptor was purified from human placental membranes by affinity chromatography. Tryptic digest of the protein extracted from a sodium dodecyl sulfate-polyacrylamide gel elec... | 18,779,389 |
Natural killer T-cell autoreactivity leads to a specialized activation state. | Natural killer T (NKT) cells are innate-like T cells that recognize specific microbial antigens and also display autoreactivity to self-antigens. The nature of NKT-cell autoreactive activation remains poorly understood. We show here that the mitogen-activated protein kinase (MAPK) pathway is operative during human NKT-... | 18,779,390 |
Cardiac involvement in patients with limb-girdle muscular dystrophy type 2 and Becker muscular dystrophy. | To investigate the extent of cardiac involvement in patients with 1 of the 12 groups of recessively inherited limb-girdle muscular dystrophy type 2 (LGMD2A-L) and Becker muscular dystrophy (BMD). Prospective screening. Neuromuscular Clinic and Department of Cardiology at Rigshospitalet. Patients One hundred one patient... | 18,779,423 |
Role of the neuropathology of Alzheimer disease in dementia in the oldest-old. | Neuritic plaques (NPs) and neurofibrillary tangles (NFTs) in the brain, especially in the hippocampus, entorhinal cortex, and isocortex, are hallmark lesions of Alzheimer disease and dementia in the elderly. However, this association has not been extensively studied in the rapidly growing population of the very old. To... | 18,779,425 |
Particulate air pollution as a risk factor for ST-segment depression in patients with coronary artery disease. | The association of particulate matter (PM) with cardiovascular morbidity and mortality is well documented. PM-induced ischemia is considered a potential mechanism linking PM to adverse cardiovascular outcomes. In a repeated-measures study including 5979 observations on 48 patients 43 to 75 years of age, we investigated... | 18,779,445 |
Actigraphy-measured sleep characteristics and risk of falls in older women. | Prior studies have suggested that insomnia and self-reported poor sleep are associated with increased risk of falls. However, no previous study, to our knowledge, has tested the independent associations of objectively estimated characteristics of sleep and risk of falls, accounting for the use of commonly prescribed tr... | 18,779,464 |
Consensus conference: multimodality management of early- and intermediate-stage non-small cell lung cancer. | Surgery is the mainstay of treatment in early- and intermediate-stage non-small cell lung cancer (NSCLC), yet recurrences are frequent. Studies have documented the benefits of chemotherapy administered after resection, but a number of questions remain regarding how overall outcomes can be further improved. To provide t... | 18,779,538 |
An intervention for treating alcohol dependence: relating elements of Medical Management to patient outcomes with implications for primary care. | Alcohol dependence, frequently seen in medical settings, is a major problem that affects the health and well-being of many individuals and their families. The purpose of this study was to examine the relationship between treatment outcomes and patient and clinician factors specifically associated with a medically orien... | 18,779,548 |
Peripheral Abeta subspecies as risk biomarkers of Alzheimer's disease. | Plasma Abeta42 and Abeta40 levels are putative biomarkers for Alzheimer's disease (AD), but their significance and predictive value have been inconclusive. In AD transgenic models, plasma and cerebrospinal fluid levels of Abeta42 and Abeta40 increase with age but subsequently decrease when Abeta begins to accumulate in... | 18,779,561 |
Hierarchies of networked phases induced by multiple liquid-liquid critical points. | Nanoparticles and colloids functionalized by four single strands of DNA can be thought of as designed analogs to tetrahedral network-forming atoms and molecules, with a difference that the attached DNA strands allow for control of the length scale of bonding relative to the core size. We explore the behavior of an expe... | 18,779,565 |
Sinusoidal obstructive syndrome diagnosed with superparamagnetic iron oxide-enhanced magnetic resonance imaging in patients with chemotherapy-treated colorectal liver metastases. | To assess the predictive value of superparamagnetic iron oxide (SPIO) -enhanced T2-weighted gradient echo (GRE) imaging to determine the presence and severity of sinusoidal obstructive syndrome (SOS). Sixty hepatic resection patients with colorectal metastases treated with chemotherapy underwent unenhanced magnetic res... | 18,779,617 |
Nanofiber applications for burn care. | Nanotechnology is a growing field of manufactured materials with sizes less than 1 mum, and it is particularly useful in the field of medicine because these applications replicate components of a cell's in vivo environment. Nanofibers, which mimic collagen fibrils in the extracellular matrix (ECM), can be created from ... | 18,779,672 |
The relationship of self-reported sleep disturbance, mood, and menopause in a community study. | The aim of this study was to assess the relationship between sleep disturbance, mood, menopausal status, and vasomotor symptoms in middle-aged women in Kinmen. A community-based sample of 1,113 Taiwanese women aged 43 to 57 years who were living on the island of Kinmen were recruited in this cross-sectional study. Meno... | 18,779,680 |
The role of high frequency oscillatory ventilation in the management of children with severe traumatic brain injury and concomitant lung pathology. | To report the use of high frequency oscillatory ventilation (HFOV) in two children with severe traumatic brain injury and concurrent lung pathology where conventional mechanical ventilation was ineffective. : Case report. Regional intensive care unit in a pediatric teaching hospital. Two severely head-injured children ... | 18,779,699 |
Peripheral T-cell lymphoma with follicular T-cell markers. | Peripheral T-cell lymphomas (PTCLs) in western countries are uncommon tumors with unfavorable prognosis. They may be subclassified as anaplastic large-cell lymphomas (ALCLs), angioimmunoblastic-T-cell lymphomas (AITLs), or unspecified peripheral T-cell lymphomas (PTCLs-U). It has recently been demonstrated that AITLs o... | 18,779,728 |
Compartment syndrome of the foot after calcaneal fractures. | A compartment syndrome is a condition in which high pressure within a closed fascial space causes reduced blood flow with nerve and muscle ischaemia. Untreated compartment syndrome leads to ischaemia with necrosis, contractures, myofibrosis and irreversible functional impairment in the involved part of the limb. Calcan... | 18,779,771 |
Characterization of pancreatic ductal cells in human islet preparations. | Substantial amounts of nonendocrine cells are implanted as part of human islet grafts, and a possible influence of nonendocrine cells on clinical islet transplantation outcome has been postulated. There are currently no product release criteria specific for nonendocrine cells due to lack of available methods. The aims ... | 18,779,781 |
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