title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Comparison of kidney size between patients with Balkan endemic nephropathy and other kidney diseases. | The aim of this study was to assess the relationship between kidney dimensions and creatinine clearance (Ccr) in patients with Balkan endemic nephropathy (BEN), nephrosclerosis (NSc), glomerulonephritis (GN), diabetic nephropathy (DN) and in healthy persons. The main objective was to find out at which stage of BEN the ... | 18,781,078 |
p27Kip1 promotes migration of metastatic hepatocellular carcinoma cells. | p27(Kip1) (p27) is a member of the Cip/Kip family of cyclin/cyclin-dependent kinase inhibitors (CKIs), and its CKI-independent function regarding cell motility modulation has been discovered. However, it is controversial whether p27 promotes or inhibits cell migration. This study investigates the migration regulatory r... | 18,781,093 |
[The evaluation of the distal airway inflammation of well controlled asthmatic patients using sputum induction by inhalation of 10% hypertonic saline for 15 minutes]. | As the clinical importance of treatment to asthmatic distal airway has been recognized, this study aimed to evaluate the efficacy of the 10% hypertonic saline-induced 15 minutes long-inhaled method to assess the inflammatory situation in the distal airways. The subjects were 16 healthy volunteers and 29 patients with w... | 18,781,105 |
Pediatric anxiety disorders: management in primary care. | Anxiety disorders are common in children and adolescents, with prevalence rates varying from 6 to 20%. These disorders can result in significant academic, social, and familial impairment. Early identification in pediatric primary care and effective management may help improve outcomes. Self-report measures of pediatric... | 18,781,116 |
Fusion in the ETS gene family and prostate cancer. | It has recently been shown that the majority of prostate cancers harbour a chromosomal rearrangement that fuses the gene for an androgen-regulated prostate-specific serine protease, TMPRSS2, with a member of the ETS family of transcription factors, most commonly ERG. These are among the most common genetic alterations ... | 18,781,147 |
Trends in large-scale mouse mutagenesis: from genetics to functional genomics. | The primary goal of mouse mutagenesis programmes is to develop a fundamental research infrastructure for mammalian functional genomics and to produce human disease models. Many large-scale programmes have been ongoing since 1997; these culminated in the International Knockout Mouse Consortium (IKMC) in 2007 with the ai... | 18,781,157 |
Genome-wide linkage screen for stature and body mass index in 3.032 families: evidence for sex- and population-specific genetic effects. | Stature (adult body height) and body mass index (BMI) have a strong genetic component explaining observed variation in human populations; however, identifying those genetic components has been extremely challenging. It seems obvious that sample size is a critical determinant for successful identification of quantitativ... | 18,781,184 |
The E-cadherin (CDH1)--160 C/A polymorphism and prostate cancer risk: a meta-analysis. | Published data on the association between E-cadherin (CDH1) -160 C/A polymorphism and prostate cancer (PCA) risk are inconclusive. To derive a more precise estimation of the relationship, a meta-analysis was performed. A logistic regression approach proposed for molecular association studies was used to estimate a biol... | 18,781,193 |
Uric acid nephrolithias in the era of noncontrast computed tomography. | We report 2 patients who presented with uric acid renal calculi. Both patients had previously been treated unsuccessfully for their stones with shock wave lithotripsy and were referred to our centre for percutaneous nephrolithomy. We were able to avoid surgery in both cases owing to the recognition of uric acid stone c... | 18,781,215 |
Retrospective assessment of the association between drinking and condom use. | Retrospective reports of the association between drinking and high-risk sexual behavior can be biased by implicit theories of the effects of drinking or may represent post hoc justifications instead of accurate reports of behavior. Using data from a daily diary study, we compared daily reports of condom use when drinki... | 18,781,253 |
Effects of elevated CO(2) and O(3) on phenolic compounds in spring wheat and maize leaves. | C(3) crops are generally considered more sensitive than C(4) crops to the elevated CO(2) and O(3), but it is unclear whether the concentrations of phenolic compounds in them are affected. In this paper, an enrichment experiment with open-top chamber was conducted to examine the effects of elevated CO(2), O(3), and thei... | 18,781,273 |
[Hereditary Alzheimer's disease with amyloid angiopathy caused by amyloid precursor protein locus]. | We report a patient with early-onset autosomal dominant dementia. The CSF showed increased levels of tau protein and decreased amyloid beta (ratio 42:40) typical for Alzheimer's disease. Cerebral MRI revealed vascular lesions and white-matter changes around the posterior horns of the ventricles with only moderate atrop... | 18,781,290 |
Histological and ultrastructural evaluation of Leeds-Keio ligament 20 years after implant: a case report. | We were capable of undertaking a histological and ultrastructural evaluation of an intact Leeds-Keio ligament implanted 20 years ago to assess the neoligamentization process inside this artificial ligament. The histological evaluation disclosed a collagen fibrils orientation very close to the structure of a normal ante... | 18,781,294 |
[Endophthalmitis after repeated bevacizumab injections]. | Symptoms resembling endophthalmitis developed 1 day after the seventh injection of bevacizumab in a 76-year-old woman with extrafoveal occult choroidal neovascularization in conjunction with age-related macular degeneration. The diagnosis reached was an immune reaction with pseudohypopyon after repeated bevacizumab inj... | 18,781,307 |
Tumor-infiltrating macrophages can predict favorable prognosis in hepatocellular carcinoma after resection. | To evaluate the prognostic value of tumor-associated macrophages (TAM), individually or synergistically with CD45RO + memory T cells (T(M)), in hepatocellular carcinoma (HCC) patients following resection. The infiltration of TAM and T(M) was assessed by immunohistochemistry in tissue microarray containing 302 HCC speci... | 18,781,326 |
Blood volume monitoring to adjust dry weight in hypertensive pediatric hemodialysis patients. | The aim of this study was to adjust dry weight by short-term blood volume monitoring (BVM)-guided ultrafiltration and evaluate the effects of optimizing dry weight on blood pressure (BP) control and intradialytic symptoms (IDS) in a group of hypertensive hemodialysis (HD) patients. The study was performed in four seque... | 18,781,335 |
Medical management of children with primary hypertension by pediatric subspecialists. | Our aim was to characterize medical management of children with primary hypertension (HTN) by pediatric subspecialists. We performed a medical-record review of children < or = 18 years with primary HTN seen at pediatric cardiology or pediatric nephrology clinics at an academic center. Main outcomes were whether trea... | 18,781,337 |
Sesamin supplementation increases white muscle docosahexaenoic acid (DHA) levels in rainbow trout (Oncorhynchus mykiss) fed high alpha-linolenic acid (ALA) containing vegetable oil: metabolic actions. | The effects of including an equi-mixture of sesamin and episesamin in fish diets based on vegetable oils of different fatty acid composition were examined. Sesamin/episesamin (hereafter named sesamin) was included at 0.58 g/100 g diet. The oil used in the feed was either a mixture of linseed and sunflower oils (6:4, by... | 18,781,351 |
Fluence-response dynamics of the UV-induced SOS response in Escherichia coli. | Bacteria in nature often suffer sudden stresses, such as ultraviolet (UV) irradiation, nutrient deprivation, and chemotoxins that would cause DNA damage and DNA replication failure, which in turn trigger SOS response. According to the strength and duration of the stress, the SOS system not only repairs DNA damage but a... | 18,781,362 |
Effect of sibutramine HCl on cardiac hERG K+ channel. | Common clinically used drugs block the delayed rectifier K(+) channels and prolong the cardiac action potential duration associated with long QT syndrome. Here, we investigated the mechanism of hERG K(+) channel current (I(hERG)) blockade expressed in HEK-293 cells by sibutramine HCl, a serotonin-norepinephrine reuptak... | 18,781,376 |
Semiparametric mixed-effects analysis of PK/PD models using differential equations. | Motivated by the use of semiparametric nonlinear mixed-effects modeling on longitudinal data, we develop a new semiparametric modeling approach to address potential structural model misspecification for population pharmacokinetic/pharmacodynamic (PK/PD) analysis. Specifically, we use a set of ordinary differential equa... | 18,781,382 |
Replication kinetics of Salmonella enteritidis in internal organs of ducklings after oral challenge: a quantitative time-course study using real-time PCR. | This research was undertaken to understand the replication kinetics of Salmonella enteritidis (S. enteritidis) in the internal organs of ducklings after oral challenge over a 2 wk period. A serovar-specific real-time, fluorescence-based quantitative polymerase chain reaction (FQ-PCR) assay was used to detect genomic DN... | 18,781,393 |
Frequency of Candida spp. in the oral cavity of Brazilian HIV-positive patients and correlation with CD4 cell counts and viral load. | The aim of this study was to evaluate the prevalence of Candida spp., and particularly C. dubliniensis, among oral isolates from Brazilian HIV-positive patients correlating these results with CD4 cell counts and viral load. Forty-five individuals (23 female and 22 male) diagnosed as HIV-positive by ELISA and Western-bl... | 18,781,394 |
[Non-occlusive mesenteric ischemia in a chronic dialysis patient: a case report]. | We report non-occlusive mesenteric ischemia (NOMI) in a patient with hemodialysis-dependent chronic renal failure who presented with acute onset of abdominal pain. On abdominal computed tomography (CT) and CT angiography, pneumatosis intestinalis of the small intestine and mesenteric venous gas were found with patent s... | 18,781,426 |
Dexamphetamine normalises electrophysiological activity in attention deficit-hyperactivity disorder during the Stroop task. | A case study was conducted to investigate whether dexamphetamine enhances interference control in an adult with attention deficit/hyperactivity disorder. Continuous electroencephalography was recorded both on and off dexamphetamine during performance on a Stroop task. An age-, gender- and IQ-matched control also comple... | 18,781,428 |
Asymptomatic motor cortex displacement due to a giant arachnoid cyst. | Cerebral lesions are held to induce plastic changes of the brain. Less well established, however, is how much space-occupying brain lesions may only displace functional representations. In a 66-year-old man we show, by means of functional magnetic resonance imaging and transcranial magnetic stimulation, a profound disp... | 18,781,430 |
Psychogenic memory deficits associated with functional cerebral changes: an FMRI study. | We studied a case of psychogenic amnesia by means of a functional magnetic resonance imaging (fMRI) experiment involving the retrieval of autobiographical memories. The 38-year-old patient was unable to access most of her autobiographical memories from her childhood up to 16 years of age. Compared with the forgotten pe... | 18,781,436 |
Exaggerated color perception in a patient with visual form agnosia. | Previous studies on visual form agnosic patients have shown that their color perception is relatively preserved when monochromatic figures are used. However, it is unclear whether their color perception remains normal when figures are composed of two parts in different colors. The results showed that patient X.F. had d... | 18,781,440 |
Differential reorganization of fusiform gyrus in two types of alexia after stroke. | Lesions affecting the left fusiform gyrus (FG) commonly result in dyslexia and recovery largely depends on efficient reorganization of the reading network. We performed a follow-up fMRI study to elucidate the reorganization patterns of the FG according to the recovery of reading ability in two patients (MH with pure al... | 18,781,441 |
A feeding education program to prevent mother-to-child transmission of HIV in Haiti. | In Haiti, as in most of the developing world, vertical transmission of HIV from infected mother to infant through postpartum breastfeeding remains a significant mode of transmission. As part of their prevention of mother-to-child transmission program, the Groupe Haitien d'Etude du Sarcome de Kaposi et des Infections Op... | 18,781,456 |
Being Bleuler: the second century of schizophrenia. | The aim of this paper is to examine the background to the emblematic psychiatric term, schizophrenia, the historical, cultural and social factors affecting the two men who defined modern psychiatric practice, and anticipate what lies ahead in the next century. The term schizophrenia was created by Swiss psychiatrist Eu... | 18,781,458 |
Predictors of autoimmune disease: autoantibodies and beyond. | Increased emphasis has been placed in recent years on predictive biomarkers to foretell the onset or future course of disease. In autoimmune diseases, autoantibodies have proven to be valuable biomarkers because of their technical sensitivity, specificity, and stability during storage. Their predictive value is limited... | 18,781,467 |
Cross-talk between anti-beta1-adrenoceptor antibodies in dilated cardiomyopathy and Chagas' heart disease. | Anti-beta(1)-adrenoceptor autoantibodies, first described in sera of patients with Chagas' disease, are now well documented in patients with idiopathic dilated cardiomyopathy. The following review summarizes the knowledge we have about the structural basis of receptor-antibody interactions, about their mechanisms of ac... | 18,781,468 |
Recombinant cardiac myosin fragment induces experimental autoimmune myocarditis via activation of Th1 and Th17 immunity. | The specificity and function of T helper (Th) immune responses underlying the induction, progression, and resolution of experimental autoimmune myocarditis (EAM) in A/J mice are unclear. Published data suggest involvement of both Th1 and Th2 responses in EAM; however, the previous inability to assess antigen-specific i... | 18,781,477 |
Conjugated equine estrogen, raloxifene and arterial stiffness in postmenopausal women. | We analyzed the influence of conjugated equine estrogen (CEE) and raloxifene on arterial stiffness. Sixty-seven healthy, normotensive women 1-10 years into menopause were assigned to receive oral placebo, conjugated equine estrogen 0.625 mg, or raloxifene 60 mg. Arterial stiffness was evaluated by measuring the carotid... | 18,781,483 |
Restless legs syndrome among women: prevalence, co-morbidity and possible relationship to menopause. | Restless legs syndrome (RLS) is a common neurological movement disorder with a female preponderance and an increasing prevalence with age. During the menopausal transition, sleep is affected. Prior studies suggest that female hormones are associated with the clinical manifestation of RLS. A random sample of 5000 women ... | 18,781,488 |
Infant hearing loss in South Africa: age of intervention and parental needs for support. | Hearing loss is referred to as the silent, overlooked epidemic in developing countries, and data reporting the mean age of diagnosis and intervention is virtually non-existent due to limited systematic or routine screening programs. The objective of this paper is to present findings of recent practice in early diagnosi... | 18,781,511 |
Statistical assessment of analytical method transfer. | Analytical method transfer is an important part of analytical method development and maintenance. The current common practice of analytical method transfer is based on the equivalence of the means between the original laboratory and the receiving laboratory. However, for some assays the most scientifically sound approa... | 18,781,532 |
Design and analysis of analytical method transfer studies. | A method transfer study is designed to successfully transfer technology from an origination laboratory to a destination laboratory. Following quality by design principles, a method transfer study is part of an analytical process to confirm the repeatability and ruggedness of the technology to be transferred. The primar... | 18,781,533 |
[Psychological consequences of perinatal loss in subsequent pregnancies--a comparative study]. | Pregnancies after perinatal loss occur often. However, little is known about the need of secondary psychological prevention in these instances. Therefore we investigated psychological disorder and distress during the subsequent pregnancy after perinatal loss. We compared psychological symptoms in pregnant women with an... | 18,781,543 |
[Differential indication of inpatient and day clinic treatment in psychosomatics]. | Aim of the "DINSTAP"-study is to identify criteria that are of importance for a decision between inpatient or day clinic treatment in patients that are usually admitted to psychosomatic clinics in Germany. 299 inpatient and 268 day clinic treatment episodes from 10 clinics were included in the study. Next to basic data... | 18,781,542 |
Modified chitosans for oral drug delivery. | The cationic polysaccharide chitosan has been extensively studied for oral drug delivery. In recent years, chemically modified chitosans developed in order to improve the properties of chitosan for oral drug delivery have gained increasing attention. Representatives of these novel polymers are trimethyl-chitosans, thio... | 18,781,621 |
Improving powder flow properties of citric acid by crystal hydration. | A batch of poorly flowing citric acid anhydrate was exposed to 69.9% relative humidity to prepare pure monohydrate with nearly identical particle size and morphology but different surface properties. Flow properties of the powders were tested using a ring shear cell. Results show the hydration can significantly improve... | 18,781,624 |
Oxidation of methionine residue at hydrophobic core destabilizes p53 tetrameric structure. | The tumor suppressor protein p53 is a tetrameric phosphoprotein that induces cell cycle, development, and differentiation by regulating the expression of target genes. The tetramerization of p53 is essential for its tumor suppressor functions. It has been known that oxidation of proteins affects their structure and fun... | 18,781,628 |
The impact of protein concentration on mannitol and sodium chloride crystallinity and polymorphism upon lyophilization. | The effect of protein concentration, in the range of 0-26 mg/mL for two Fc-fusion proteins, on the crystallinity and polymorphism of mannitol and sodium chloride in a lyophilized model formulation was examined. Mannitol hydrate levels were quantified based on moisture data and correlated to the X-ray diffraction peak a... | 18,781,637 |
Annual assessment spirometry, plethysmography, and gas transfer in cystic fibrosis: do they predict death or transplantation. | The long- and short-term prognostic value of pediatric spirometry, plethysmography, and gas transfer measurements in cystic fibrosis (CF) were assessed. Two hundred ninety-eight children with CF and >or=4 annual assessment lung function measurements at a single institution were analyzed in mid childhood. Long-term o... | 18,781,653 |
Functional organization of the basal ganglia: therapeutic implications for Parkinson's disease. | The basal ganglia (BG) are a highly organized network, where different parts are activated for specific functions and circumstances. The BG are involved in movement control, as well as associative learning, planning, working memory, and emotion. We concentrate on the "motor circuit" because it is the best understood an... | 18,781,672 |
Molecular mechanisms underlying levodopa-induced dyskinesia. | Although levodopa remains the most effective drug for the symptomatic treatment of Parkinson's disease, chronic therapy with this pharmacological compound initiates a complex cascade of cellular and molecular downstream effects resulting in the development of abnormal involuntary movements. The precise mechanisms under... | 18,781,674 |
Effect of enzyme supplementation at moderate cellulase loadings on initial glucose and xylose release from corn stover solids pretreated by leading technologies. | Moderate loadings of cellulase enzyme supplemented with beta-glucosidase were applied to solids produced by ammonia fiber expansion (AFEX), ammonia recycle (ARP), controlled pH, dilute sulfuric acid, lime, and sulfur dioxide pretreatments to better understand factors that control glucose and xylose release following 24... | 18,781,688 |
A population analysis of VEGF transgene expression and secretion. | The induction of therapeutic angiogenesis with gene therapy approaches has received considerable interest and some limited clinical success. A major drawback to this approach is a lack of understanding of the pharmacokinetics of therapeutic protein delivery. This has become increasingly more relevant as recent studies ... | 18,781,692 |
Sensitive liquid chromatography tandem mass spectrometry method for the quantification of Quetiapine in plasma. | A sensitive high-performance liquid chromatography-tandem mass spectrometry method was developed and validated for the quantification of quetiapine in rat plasma. Following liquid-liquid extraction, the analyte was separated using a gradient mobile phase on a reverse-phase column and analyzed by MS/MS in the multiple r... | 18,781,706 |
Coexistence of two aggregation modes in exotic liquid-crystalline superstructure: systematic maximum entropy analysis for cubic mesogen, 1,2-bis(4'-n-alkoxybenzoyl)hydrazine [BABH(n)]. | Structure of a complex superstructure self-organized by thermotropic mesogen, 1,2-bis(4'- n-alkoxybenzoyl)hydrazine [BABH(n), where n is the number of carbon atoms in an alkoxy chain] was studied while paying special attention to the structure at the molecular level. Maximum entropy (MEM) analysis revealed that the mol... | 18,781,713 |
A polarizable force field for computing the infrared spectra of the polypeptide backbone. | The shapes of the amide bands in the infrared (IR) spectra of proteins and peptides are caused by electrostatically coupled vibrations within the polypeptide backbone and code the structures of these biopolymers. A structural decoding of the amide bands has to resort to simplified models because the huge size of these ... | 18,781,720 |
Marangoni flow of Ag nanoparticles from the fluid-fluid interface. | Fluid flow is observed when a volume of passivated Ag nanoparticles suspended in chloroform is mixed with a water/ethanol (v/v) mixture containing acidified 11-mercaptoundecanoic acid. Following mechanical agitation, Ag nanoparticles embedded in a film are driven from the organic-aqueous interface. A reddish-brown colo... | 18,781,724 |
Thermally induced magnetic anomalies in solvates of the bis(hexafluoroacetylacetonate)copper(II) complex with pyrazolyl-substituted nitronyl nitroxide. | We succeeded in synthesizing of a whole family of isostructural solvates of the copper(II) hexafluoroacetylacetonate complex with pyrazolyl-substituted nitronyl nitroxide (L): Cu(hfac)2L x 0.Solv. The main feature inherent in nature of Cu(hfac)2L x 0.5 Solv single crystals is their incredible mechanical stability and a... | 18,781,735 |
Unsymmetrical platinum(II) phosphido derivatives: oxidation and reductive coupling processes involving platinum(III) complexes as intermediates. | Reaction of the trinuclear [NBu 4] 2[(R F) 2Pt(mu-PPh 2) 2Pt(mu-PPh 2) 2Pt(R F) 2] ( 1, R F = C 6F 5) with HCl results in the formation of the unusual anionic hexanuclear derivative [NBu 4] 2[{(R F) 2Pt(mu-PPh 2) 2Pt(mu-PPh 2) 2Pt(mu-Cl)} 2] ( 4, 96 e (-) skeleton) through the cleavage of two Pt-C 6F 5 bonds. The react... | 18,781,738 |
The difference a Se makes? Oxygen-tolerant hydrogen production by the [NiFeSe]-hydrogenase from Desulfomicrobium baculatum. | Protein film voltammetry studies of the [NiFeSe]-hydrogenase from Desulfomicrobium baculatum show it to be a highly efficient H2 cycling catalyst. In the presence of 100% H2, the ratio of H2 production to H2 oxidation activity is higher than for any conventional [NiFe]-hydrogenases (lacking a selenocysteine ligand) tha... | 18,781,742 |
Oxidation of a mustard gas analogue using an aldehyde/O2 system catalyzed by V-doped mesoporous silica. | Vanadium-doped mesoporous silica was shown to be an effective heterogeneous catalyst for the oxidation of a mustard gas analogue, 2-chloroethyl ethyl sulfide (CEES), in the presence of an aldehyde and molecular oxygen. The oxidation was shown to involve a radical mechanism, which was indicated by the appearance of an i... | 18,781,745 |
In situ observation of the internal structure and composition of biomineralized Emiliania huxleyi calcite by solid-state NMR Spectroscopy. | Biomineralization, particularly the formation of calcium carbonate structures by organisms under ambient conditions, is of vast fundamental and applied interest. Organisms finely control all aspects of the formation of the biomaterials: composition, polymorph, morphology, and macroscopic properties. While in situ molec... | 18,781,749 |
Solution structure of a peptide nucleic acid duplex from NMR data: features and limitations. | This paper describes the results of a 1D and 2D NMR spectroscopy study of a palindromic 8-base pair PNA duplex GGCATGCC in H2O and H2O-D2O solutions. The (1)H NMR peaks have been assigned for most of the protons of the six central base pairs, as well as for several amide protons of the backbone. The resulting 36 interb... | 18,781,753 |
Development of a capillary electrophoresis-based immunoassay with laser-induced fluorescence for the detection of carbaryl in rice samples. | A capillary electrophoresis-based competitive immunoassay (CEIA) with a laser-induced fluorescence (LIF) detector for the determination of carbaryl was developed. The method was based on the competitive reactions between fluorescently labeled carbaryl tracer (Ag*) and free carbaryl (Ag) with a limited amount of anticar... | 18,781,759 |
Algicidal activity of stilbene analogues. | Continuing our search for natural product and natural product-based compounds for the control of off-flavor in catfish, 29 stilbene analogues were synthesized and evaluated for algicidal activity against the 2-methylisoborneol (MIB)-producing cyanobacterium Oscillatoria perornata. The cis and trans isomers of 4-(3,5-di... | 18,781,760 |
Doubly responsive polymer-microgel composites: rheology and structure. | Mixtures of alkali swellable microgels and linear PNIPAm chains exhibit doubly responsive properties both with pH and temperature. Below the lower critical solution temperature (LCST), the linear chains of PNIPAm are soluble and increase the osmotic pressure outside the microgels, which causes them to deswell. Above th... | 18,781,781 |
Local concentration of gel phase domains in supported lipid bilayers under light irradiation in binary mixture of phospholipids doped with dyes for photoinduced activation. | Recently, lipid bilayers supported on solid substrates are considered to offer potential as biological devices utilizing biological membranes and membrane proteins. In particular, artificially patterned supported bilayers hold great promise for the development of biological devices. In this study, we show control of th... | 18,781,791 |
Quantitative analysis of global ubiquitination in HeLa cells by mass spectrometry. | Ubiquitination regulates a host of cellular processes by labeling proteins for degradation, but also by functioning as a regulatory, nonproteolytic posttranslational modification. Proteome-wide strategies to monitor changes in ubiquitination profiles are important to obtain insight into the various cellular functions o... | 18,781,797 |
Wafer-scale reduced graphene oxide films for nanomechanical devices. | We report a process to form large-area, few-monolayer graphene oxide films and then recover the outstanding mechanical properties found in graphene to fabricate high Young's modulus (<E> =185 GPa), low-density nanomechanical resonators. Wafer-scale films as thin as 4 nm are sufficiently robust that they can be de... | 18,781,807 |
Chromatin-modifying enzymes as therapeutic targets--Part 1. | Disease pathogenesis may result from genetic alterations and/or a more diverse group of epigenetic changes. While events such as DNA methylation are well established, there is significant interest in nucleosome remodeling, RNA interference and histone modifications, as mechanisms that underlie epigenetic effects. While... | 18,781,828 |
Inferring ancestral gene orders for a family of tandemly arrayed genes. | Tandemly arrayed genes (TAG) constitute a large fraction of most genomes and play important biological roles. They evolve through unequal recombination, which places duplicated genes next to the original ones (tandem duplications). Many algorithms have been proposed to infer a tandem duplication history for a TAG clust... | 18,781,832 |
Magnetic reconstruction of three-dimensional tissues from multicellular spheroids. | Multicellular spheroids are useful building blocks for tissue reconstruction. This study reports a simple technique called magnetic organoid patterning for assembly of spheroids into a complex tissue-mimicking construct. Spheroids were labeled magnetically using co-incubation of RGD peptide-conjugated magnetic micropar... | 18,781,835 |
CYP2C19 and nongenetic factors predict poor responsiveness to clopidogrel loading dose after coronary stent implantation. | To investigate an association of responsiveness to clopidogrel loading dose with genotypes of cytochrome P450 (CYP) 2C19, other CYP isozymes and nongenetic factors in patients with coronary artery disease. Genotyping for CYP2C19 (*2, *3 and *17), CYP3A4*1B and CYP3A5*3 variants was performed in patients (n = 237) who u... | 18,781,853 |
Influence of enzyme-inducing antiepileptic drugs on trough level of imatinib in glioblastoma patients. | Imatinib mesylate is used in combination with hydroxyurea (HU) in ongoing clinical phase II studies in recurrent glioblastoma multiforme (GBM). CYP3A4 enzyme-inducing antiepileptic drugs (EIAEDs) like carbamazepine, phenytoin, and oxcarbazepine--as well as non-EIAEDs like valproic acid, levetiracetam, and lamotrigine--... | 18,781,906 |
New methods for the identification of efflux mediated MDR bacteria, genetic assessment of regulators and efflux pump constituents, characterization of efflux systems and screening for inhibitors of efflux pumps. | We have developed a number of methods that identify efflux pump mediated multi-drug resistant bacteria, characterize efflux systems and screen for inhibitors of efflux pumps. These approaches were complemented by the quantification of the expression of genes that regulate and code for constituents of efflux pumps. The ... | 18,781,922 |
Biophysical characterization of in- and efflux in Gram-negative bacteria. | Gram-negative bacteria developed a number of tools to avoid accumulation of cell-toxic compounds. The outer membrane as a first defense system is tightly packed reducing permeation through the lipid membrane. Water-soluble compounds may penetrate through membrane channels called porins. Once inside the periplasmic spac... | 18,781,924 |
Status of cytokines in ischemia reperfusion induced heart injury. | Extensive investigations have implicated cytokines such as tumour necrosis factor (TNF)- alpha and interleukin (IL)-1, and IL-6 as contributing to the pathology of ischemia-reperfusion (I/R) injury, since an increase in the production of those cytokines was clinically detected after myocardial infarction and cardiopulm... | 18,781,928 |
Extra-hematopoietic effects of erythropoietin. | Erythropoietin (Epo) has a long-lasting history as the hormon that allows production of red blood cells. It is now well established that, besides erythropoiesis, Epo has the ability to sustain proliferation of myeloid lineages. More recently, extra-haematological roles have been described for Epo. Its receptor, EpoR, h... | 18,781,929 |
Iron involvement in multiple signaling pathways of atherosclerosis: a revisited hypothesis. | Atherosclerosis being a leading death cause in many countries is a chronic inflammatory process in which inflammation, immune activation, and oxidative stress are interactively involved. Some epidemiological and many experimental studies suggest that development of atherosclerosis is associated with the amount of iron ... | 18,781,942 |
HGF/MET signaling in ovarian cancer. | Ovarian cancer is the leading cause of death from gynecological cancers in North America and Europe. Despite its clinical significance, the factors that regulate the development and progression of ovarian cancer are among the least understood of all major human malignancies. A growth factor with pleiotropic effects, wh... | 18,781,954 |
Cardiovascular disease in patients with diabetic nephropathy. | Diabetic nephropathy, which represents a major form of chronic kidney disease (CKD), is a leading cause of end-stage renal disease worldwide, and is also a risk factor for cardiovascular disease (CVD). Patients with diabetes and CKD have poorer outcomes after myocardial infarction. The underlying pathogenic mechanism t... | 18,781,960 |
Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands: novel pharmacological agents in the treatment of ischemia reperfusion injury. | Peroxisome proliferator-activated receptor-gamma (PPAR-gamma) ligands constitute important insulin sensitizers that have already been used for the treatment of human metabolic disorders, exerting also pleiotropic effects on inflammatory related diseases and cancer. Ischemia-reperfusion injury that is mainly associated ... | 18,781,963 |
The many faces of amyloid beta in Alzheimer's disease. | The 'amyloid cascade hypothesis' links amyloid beta peptide (Abeta) with the pathological process of Alzheimer's disease (AD) and it still awaits universal acceptance. Amyloid precursor protein (APP), through the actions of the gamma-secretase complex, eventually becomes a different Abetaspecies. The various Abeta spec... | 18,781,964 |
CNS immune surveillance and neuroinflammation: endocannabinoids keep control. | To avoid inflammatory escalation, the central nervous system (CNS) harbors an impressive arsenal of cellular and molecular mechanisms enabling strict control of immune reactions. We here summarize studies suggesting that the old paradigm of the "CNS immune privilege" is overly simplistic. The immune system is allowed t... | 18,781,977 |
The endocannabinoid system in amyotrophic lateral sclerosis. | Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative condition characterised by the selective loss of motor neurons from the spinal cord, brainstem and motor cortex. Although the pathogenic mechanisms that underlie ALS are not yet fully understood, there is significant evidence that several neurotoxic mecha... | 18,781,981 |
The endocannabinoid system and multiple sclerosis. | Multiple sclerosis (MS) is a neurodegenerative disease that is characterised by repeated inflammatory/demyelinating events within the central nervous system (CNS). In addition to relapsing-remitting neurological insults, leading to loss of function, patients are often left with residual, troublesome symptoms such as sp... | 18,781,983 |
Brain tumour stem cells: implications for cancer therapy and regenerative medicine. | The cancer relapse and mortality rate suggest that current therapies do not eradicate all malignant cells. Currently, it is accepted that tumorigenesis and organogenesis are similar in many respects, as for example, homeostasis is governed by a distinct sub-population of stem cells in both situations. There is increasi... | 18,782,002 |
Trends in metabolic syndrome and gene networks in human and rodent models. | Metabolic syndrome (MetS) can be considered a pheno-physiological cluster of metabolically interrelated risk factors for diabetes mellitus and cardiovascular disease. MetS has emerged as a result of complex interactions among environmental stresses and MetS gene networks and their products. In this review we summarize ... | 18,782,016 |
Potassium channel openers and improvement of toxic stress: do they have role in the management of inflammatory bowel disease? | Inflammatory bowel disease (IBD) is a progressive condition in gastrointestinal tract, which refers to two idiopathic diseases; ulcerative colitis and Crohn's disease. Although certain etiology of these conditions is not known, it seems that an abnormality in reaction and regulation of the immune system plays an import... | 18,782,019 |
Synthesis and antimalarial activity of new amino analogues of amodiaquine. | Amodiaquine remains one of the most prescribed antimalarial 4-aminoquinoline. To assess the importance of the 4'-hydroxyl group and subsequent hydrogen bond in the antimalarial activity of amodiaquine (AQ), a series of new analogues in which this functionality was replaced by various amino groups was synthesized. The i... | 18,782,038 |
N,N-Bis(trifluoromethylquinolin-4-yl)diamino alkanes: synthesis and antimalarial activity. | A series of N,N-bis(trifluoromethylquinolin-4-yl)- and N,N-bis[2,8-bis(trifluoromethyl)quinolin-4-yl] diamino alkane and piperazine derivatives were synthesised by employing a simple and rapid displacement reaction of the 4-chloro group on the 2-trifluoromethyl- and 2,8-bis(trifluoromethyl)-quinoline by diaminoalkane o... | 18,782,040 |
Dibenzoylmethane activates Nrf2-dependent detoxification pathway and inhibits benzo(a)pyrene induced DNA adducts in lungs. | Cigarette smoke derived carcinogens have been identified as the main agents implicated in lung carcinogenesis. Epidemiological as well as animal studies have indicated that certain phytochemicals can block the carcinogenic process by enhancing the detoxification of environmental and or dietary carcinogens. Dibenzoylmet... | 18,782,044 |
Synthesis and biological evaluation of naphthalene-1,4-dione derivatives as potent antimycobacterial agents. | The recent increase in the incidence of tuberculosis with the emergence of multi-drug resistant (MDR) cases has lead to the search for new drugs that are effective against MDR strains of Mycobacterium tuberculosis (M. tb) and can augment the potential of existing drugs against tuberculosis. In the present study a serie... | 18,782,046 |
Crystal structure of SCO6571 from Streptomyces coelicolor A3(2). | SCO6571 protein from Streptomyces coelicolor A3(2) was overexpressed and purified using Rhodococcus erythropolis as an expressing host. Crystals of selenomethionine-substituted SCO6571 have been obtained by vapor diffusion method. SCO6571 crystals diffract to 2.3 A and were found to belong to the orthorhombic space gro... | 18,782,066 |
Chemotherapy in addition to preoperative radiotherapy in locally advanced rectal cancer - a systematic overview. | The value of chemotherapy with radiotherapy has been explored in recent randomised clinical trials in locally advanced rectal cancer (LARC). An overview of these trials was made together with a discussion of what constitutes LARC. Although imaging is required for adequate staging of primary rectal cancer, the term 'loc... | 18,782,078 |
The role of cetuximab and other epidermal growth factor receptor monoclonal antibodies in the treatment of advanced non-small cell lung cancer. | Lung cancer continues to be the leading cause of cancer-related deaths in the western civilization and developing countries. Non-small cell lung cancer (NSCLC) accounts for > 85% of all cases of lung cancer. Since most patients with NSCLC have advanced disease at diagnosis, to date chemotherapy with third-generation... | 18,782,080 |
Mediterranean diet is associated with reduced asthma and rhinitis in Mexican children. | Diet during pregnancy and childhood has been suggested to play an important role in children's asthma risk. We assessed whether the adherence to a Mediterranean dietary pattern, for children in the last 12 months and their mothers during pregnancy, was associated with both childhood asthma and allergic rhinitis. A cros... | 18,782,109 |
Alterations of the ocular surface epithelial MUC16 and goblet cell MUC5AC in patients with atopic keratoconjunctivitis. | An increased understanding of the ocular surface at cellular level in the conjunctiva and the cornea may help explain the pathogenesis and the subsequent clinical appearance of atopic ocular allergies, which may be potentially blinding. To investigate the MUC16 and MUC5AC alterations, tear function and the ocular surfa... | 18,782,111 |
Histamine H4 receptors modulate dendritic cell migration through skin--immunomodulatory role of histamine. | Dendritic cells (DC) are the major antigen-presenting cells and play a key role in adaptive immunity as they are able to activate naive T cells. It was recently described, that the histamine H(4) receptor (H4R) is present on human monocyte-derived DC and that chemotaxis and T-helper (Th)1-Th2 polarization is mediated b... | 18,782,117 |
Clinical practice of functional electrical stimulation: from "Yesterday" to "Today". | Functional electrical stimulation (FES) is an accepted treatment method for paresis or paralysis after spinal cord and head injury as well as stroke and other neurological upper motor neuron disorders. At the beginning, FES worked like an electrophysiological brace for the correction of drop foot of patients after a st... | 18,782,124 |
Searching for realism, structure and agency in Actor Network Theory. | Superficially, Actor Network Theory (ANT) and critical realism (CR) are radically opposed research traditions. Written from a realist perspective, this paper asks whether there might be a basis for finding common ground between these two traditions. It looks in turn at the questions of realism, structure, and agency, a... | 18,782,150 |
Reconceptualizing reflexivity and dissonance in professional and personal domains. | Debates around 'reflexivity' and the construction of the gendered self within late modernity have occupied the attention of both 'reflexive modernization' theorists (Beck, Giddens and Lash 1994; Beck and Beck-Gernsheim 1996; Giddens 1991, 1992) as well as gender and feminist theorists. While theorists such as Beck and ... | 18,782,154 |
Dental utilization for Medicaid-enrolled adults with developmental disabilities in Iowa residential care facilities. | The goal of this study was to evaluate the dental utilization of Medicaid-enrolled adults in Iowa residential care facilities (n=1423). Medicaid enrollment and claims files for 2003 were used, as well as information from the Iowa Department of Inspections and Appeals. Dental utilization was defined as having any dental... | 18,782,194 |
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