title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Obesity as a perceived social signal. | Fat accumulation has been classically considered as a means of energy storage. Obese people are theorized as metabolically 'thrifty', saving energy during times of food abundance. However, recent research has highlighted many neuro-behavioral and social aspects of obesity, with a suggestion that obesity, abdominal obes... | 18,784,836 |
Tumor growth decreases NK and B cells as well as common lymphoid progenitor. | It is well established that chronic tumor growth results in functional inactivation of T cells and NK cells. It is less clear, however, whether lymphopoeisis is affected by tumor growth. In our efforts of analyzing the impact of tumor growth on NK cell development, we observed a major reduction of NK cell numbers in mi... | 18,784,839 |
A new storage medium for an avulsed tooth. | The purpose of this study is to determine the efficacy of egg white in maintaining the viability of human periodontal ligament (PDL) cells on avulsed teeth. The experimental media were: egg white, milk, Hanks' Balanced Salt Solution (HBSS) as the positive control, and tap water as the negative control. The storage time... | 18,784,856 |
The efficacy of distraction and counterstimulation in the reduction of pain reaction to intraoral injection by pediatric patients. | The aim of this clinical investigation was to determine the efficacy of distraction and counterstimulation in the reduction of pain during the administration of local anesthetics in pediatric dental patients. A total of 78 healthy children (male: 40, female: 38) ages four to five years (mean age: 4.72 years old) withou... | 18,784,857 |
Squamous cell carcinoma arising in a residual cyst: a case report. | The purpose of this report is to present a case of squamous cell carcinoma (SCC) arising from a mandibular residual cyst. Although rare, SCC may arise in the epithelial lining of odontogenic cysts. The diagnosis of the development of carcinoma from the cyst lining can only be established by histopatologic examination. ... | 18,784,867 |
[The effects of epidermal growth factor on the wound repair of junctional epithelial cells and gingival epithelial cells in vitro]. | To study the effects of epidermal growth factor (EGF) on the proliferation and cellular fill of junctional epithelium (JE) and gingival epithelium (GE) by using an in vitro wound model. EGFR mRNA was semiquantitatively determined by reverse transcriptase polymerase chain reaction (RT-PCR) and immunocytochemistry was pe... | 18,784,880 |
[Expression and activity of Cdk5/p39 during rats Vc development]. | To evaluate the different expression of Cdk5 two activators, p35 and p39 throughout rats Vc development. The changes of Cdk5 activity, expression of Cdk5 and p39 in the development in spinal trigeminal subnucleus caudalis(Vc) were studied by Western blotting, immunoprecipitation and kinase assay. Statistical analysis w... | 18,784,888 |
[Significance of emissary veins in surgical treatment of temporal paragangliomas]. | With the surgical removal of temporal paraganglioma, possible changes of the cerebral blood pathways of the Circle of Willis should be considered. If the cerebral blood drains dominates unilaterally and the pathway of drainage over the Bulbus venae jugularis is inadequate due to vessel malformation or variations or by ... | 18,784,910 |
Increased nitric oxide synthase activity and Hsp90 association in skeletal muscle following chronic exercise. | Exercise training results in dynamic changes in skeletal muscle blood flow and metabolism. Nitric oxide (NO) influences blood flow, oxidative stress, and glucose metabolism. Hsp90 interacts directly with nitric oxide synthases (NOS), increasing NOS activity and altering the balance of superoxide versus NO production. I... | 18,784,937 |
Ca(2+) signaling by T-type Ca(2+) channels in neurons. | Among the major families of voltage-gated Ca(2+) channels, the low-voltage-activated channels formed by the Ca(v)3 subunits, referred to as T-type Ca(2+) channels, have recently gained increased interest in terms of the intracellular Ca(2+) signals generated upon their activation. Here, we provide an overview of recent... | 18,784,939 |
Identifying modifier genes of monogenic disease: strategies and difficulties. | Substantial clinical variability is observed in many Mendelian diseases, so that patients with the same mutation may develop a very severe form of disease, a mild form or show no symptoms at all. Among the factors that may explain these differences in disease expression are modifier genes. In this paper, we review the ... | 18,784,943 |
Sesamin increases alpha-linolenic acid conversion to docosahexaenoic acid in atlantic salmon (Salmo salar L.) hepatocytes: role of altered gene expression. | In vitro cultivated Atlantic salmon (Salmo salar L.), hepatocytes were incubated without or with a mixture of sesamin and episesamin in order to test for possible effects on lipid metabolism. Sesamin/episesamin exposure (0.05 mM, final concentration) led to increased elongation and desaturation of (14)C 18:3n-3 to doco... | 18,784,949 |
Operative modalities and exposure to pesticides during open field treatments among a group of agricultural subcontractors. | This paper reports the results of a field study of occupational pesticide exposure (respiratory and dermal) among a group of Italian agricultural subcontractors. These workers consistently use pesticides during much of the year, thus resulting in a high exposure risk. Ten complete treatments were monitored during sprin... | 18,784,953 |
Isolation and biological activity of the multi-component sea lamprey migratory pheromone. | Migratory adult sea lampreys locate spawning streams by using a pheromone released by stream-resident conspecific larvae. It was recently reported that this pheromone is comprised of a mixture of three sulfated steroids: petromyzonamine disulfate (PADS), petromyzosterol disulfate (PSDS), and petromyzonol sulfate (PS). ... | 18,784,958 |
CCN3: Doctor Jekyll and Mister Hyde. | CCN proteins are key regulators of signaling pathways that are essential for the control of normal life, from birth to death. As such, they make use of their unique mosaic structure to interact with several other regulatory proteins and ligands that control the fate of living cells. The various functions attributed to ... | 18,784,988 |
High level of genetic diversity among the selected accessions of tea (Camellia sinensis) from abandoned tea gardens in western Himalaya. | To revive cultivation of the tea unique to the western Himalayan region, it is important to evaluate the seed-derived bushes available in the area's abandoned gardens. This study used quantitative leaf characters, catechin content, and AFLP markers to assess these China cultivar type bushes. Compared with other China c... | 18,784,998 |
Differential induction of apoptosis and inhibition of the PI3-kinase pathway by saturated, monounsaturated and polyunsaturated fatty acids in a colon cancer cell model. | Although numerous studies have shown that certain long chain fatty acids can induce apoptosis in cancer cells, the molecular mechanisms for this phenomenon are still poorly elucidated. The phosphoinositide 3-kinase (PI3-kinase) signaling pathway plays a pivotal role in the regulation of cell growth and can also contrib... | 18,785,011 |
The Emergency Headache Center at the Lariboisière Hospital: 7 years with more than 70,000 patients. | After 7 years and 70,000 patients of whom two-thirds women and one-third men, 77% aged 20-50 years, 90% residing in Paris or the suburban areas, we report our experience at the Lariboisière hospital Emergency headache Center. About two-thirds of our patients complained of primary headache, i.e., migraine, but the numbe... | 18,785,014 |
Highly efficient regioselective synthesis of 5'-O-lauroyl-5-azacytidine catalyzed by Candida antarctica Lipase B. | Enzymatic regioselective acylation of 5-azacytidine with vinyl laurate was successfully conducted with an immobilized lipase from Candida antarctica type B (i.e., Novozym 435) for the first time. The acylation of 5-azacytidine took place at its primary hydroxyl group and the desired product 5'-O -lauroyl-5-azacytidine ... | 18,785,019 |
Refolding of a staphylokinase variant y1-Sak by reverse dilution. | To develop more potent thrombolytic agents with fibrinolytic and antiplatelet aggregation activity, staphylokinase (Sak) variant Y1-Sak, a recombinant mutant of the Staphylococcus aureus protein Sak, was constructed. Y1-Sak formed an insoluble inclusion body when overexpressed in Escherichia coli strain JF1125. To obta... | 18,785,020 |
Initial experience of 3-tesla apparent diffusion coefficient values in characterizing squamous cell carcinomas of the head and neck. | With the increased clinical use of 3-Tesla (3T) magnets, it becomes important to identify the potential applications of advanced magnetic resonance (MR) imaging techniques such as diffusion-weighted imaging in head and neck pathologies. To establish the 3T apparent diffusion coefficient (ADC) values for normal neck str... | 18,785,024 |
A validated HPLC method for separation and determination of promethazine enantiomers in pharmaceutical formulations. | A simple, rapid, and validated method for separation and determination of promethazine enantiomers was developed. Promethazine was separated and quantitated on a Vancomycin Chirobiotic V column (250 x 4.6 mm), using a mixture of methanol, acetic acid, and triethylamine (100:0.1:0.1%, by volume) as a mobile phase at 20 ... | 18,785,041 |
Exercise intensity and blood pressure during sleep. | Exercise, of appropriate intensity and duration, could help maintain normotension if post-exercise hypotension persists over subsequent everyday activities. Therefore, we monitored ambulatory blood pressure (BP) for 24 h following four separate exercise bouts which differed in intensity, duration and total work complet... | 18,785,091 |
[From psychiatric symptoms to paraneoplastic syndrome]. | Two patients, a 38-year-old man and a 32-year-old woman, were admitted to a psychiatric ward. The first patient suffered from a mood disorder, personality changes and complained of several, hitherto unexplained physical symptoms. Finally the patient was diagnosed with paraneoplastic cerebellar degeneration associated w... | 18,785,107 |
Fli-1 expression in malignant melanoma. | Friend leukemia integration site 1 (Fli-1) has been reported as the first nuclear marker of endothelial differentiation; it is expressed in leukocytes and recently demonstrated in melanomas. Formalin-fixed, paraffin-embedded tissue sections from 97 melanomas including 69 cases of primary and 28 metastatic melanomas wer... | 18,785,112 |
Hepatocyte nuclear phenotype: the cross-talk between anabolic androgenic steroids and exercise in transgenic mice. | The growing and indiscriminate use of high doses of anabolic androgenic steroid (AAS) among youth and athletes has raised serious concerns about its hepatotoxic effects. Herein, the influence of AAS in the nuclear phenotype of hepatocytes was investigated in sedentary and trained mice heterozygous for the human CETP (c... | 18,785,119 |
[The diagnostic differences of asthma in the elderly]. | Asthma is a common disease among elderly persons. The prevalence of asthma in subjects aged over 65 years is 6.5-17%. The diagnosis of asthma is based on typical symptoms with confirmatory information gained from physical examination and laboratory studies. Respiratory symptoms are less specific in older people. Additi... | 18,785,129 |
Pulmonary epithelioid haemangioendothelioma--interferon 2-alpha treatment--case report. | A 62-year-old, obese woman, smoking 10 pack/year was admitted to the National Tuberculosis and Lung Diseases Research Institute to diagnose small, round opacities revealed by routine chest X-ray examination. These lesions had been observed for 5 years. The patient had been treated for psoriasis, hypertension, and insul... | 18,785,134 |
A novel method for protein-ligand binding affinity prediction and the related descriptors exploration. | In this study, a novel method was developed to predict the binding affinity of protein-ligand based on a comprehensive set of structurally diverse protein-ligand complexes (PLCs). The 1300 PLCs with binding affinity (493 complexes with K(d) and 807 complexes with K(i)) from the refined dataset of PDBbind Database (rele... | 18,785,151 |
Differentiation of embryonic stem cells into cartilage cells. | Embryonic stem (ES) cells have complete potential to form all types of cells. Although these cells have indefinite capacity for self-renewal, the mechanisms that control their lineage-restricted differentiation are not well understood. Due to their potential to form all types of cells, these cells are expected to have ... | 18,785,169 |
Differentiation of human embryonic stem cells to cardiomyocytes by coculture with endoderm in serum-free medium. | Many of the applications envisaged for human embryonic stem cells (hESC) undergoing cardiomyogenesis require that the differentiation procedure is robust and high yield. For many hESC lines currently available this is a challenge; beating areas are often obtained but subsequent analysis shows only few (<1%) cardiomy... | 18,785,170 |
Isolation of mononuclear cells from human cord blood by Ficoll-Paque density gradient. | When preparing stem cell specimens from cord blood, pre-enrichment of mononuclear cells is highly recommended to improve the recovery of rare stem cells. Mononuclear cells are easily isolated by density gradient centrifugation. In Ficoll-Paque density gradient centrifugation, anticoagulant-treated and diluted cord bloo... | 18,785,173 |
Ultrasonographic swelling ratio in the diagnosis of ulnar neuropathy at the elbow. | High-resolution ultrasound can demonstrate focal nerve enlargement in entrapment neuropathies. We hypothesized that a ratio between the nerve cross-sectional area at the site of maximal enlargement and at an unaffected site may improve diagnostic accuracy in ulnar neuropathy at the elbow (UNE), when compared to a singl... | 18,785,184 |
Characterization of humoral immune responses against p16, p53, HPV16 E6 and HPV16 E7 in patients with HPV-associated cancers. | The cellular tumor suppressor p16 is strongly overexpressed in cervical cancers and precancers. We have previously demonstrated that infiltrating T lymphocytes reactive against p16 can be found in cervical cancer patients. Here, we analyzed whether p16 induces humoral immune responses. Sera of patients with cervical ca... | 18,785,210 |
Amphiphilic branched polymers as antimicrobial agents. | Cationic amphiphilic polymers were prepared from PEI and functional ethylene carbonates bearing cationic, hydrophobic or amphiphilic groups. The polymers are designed to exhibit antimicrobial properties. In a one-step addition, different functional ethylene carbonates were added to react with the primary amine groups o... | 18,785,211 |
Isobutyl amides--potent compounds for controlling Diatraea saccharalis. | A dichloromethane-methanol extract of the seeds of Piper tuberculatum Jacq. (Piperaceae) and two isobutyl amides, 4,5-dihydropiperlonguminine (1) and pellitorine (2), which were isolated by chromatographic methods, were assayed for their lethality against the sugarcane borer Diatraea saccharalis F. (Lepidoptera: Pyrali... | 18,785,219 |
Germination requirements for 29 terrestrial and wetland wild plant species appropriate for phytotoxicity testing. | Species selected for phytotoxicity testing have been limited to a few standard crop species owing to restrictive recommendations at the regulatory level. However, guidelines by the Organisation for Economic Development and Cooperation (OECD) were recently amended in 2006 to include a list of herbaceous non-crop plant s... | 18,785,223 |
Chorea-acanthocytosis: report of two Brazilian cases. | Chorea-acanthocytosis (ChAc) is a neurodegenerative disorder characterized by chorea, neuropsychiatric disturbances and acanthocytosis, caused by mutations of VPS13A. This gene produces the protein chorein which is absent in patients with ChAc on Western blot assay. We report the first two Brazilian patients with ChAc ... | 18,785,241 |
Embedding 3D models of biological specimens in PDF publications. | By providing two examples, the option for embedding 3D models in electronic versions of life science publications is presented. These examples, presumably representing the first such models published, are developmental stages of an evertebrate (Patella caerulea, Mollusca) and a vertebrate species (Psetta maxima, Teleos... | 18,785,246 |
The use of smell identification tests in the diagnosis of Parkinson's disease in Brazil. | Smell identification tests may be of routine clinical value in the differential diagnosis of PD but are subject to cultural variation and have not been systematically evaluated in the Brazilian population. We have applied culturally adapted translations of the University of Pennsylvania 40-item smell identification tes... | 18,785,265 |
Patency and Agile capsules. | Small bowel strictures can be missed by current diagnostic methods. The Patency capsule is a new non-endoscopic dissolvable capsule which has as an objective of checking the patency of digestive tract, in a non-invasive manner. The available clinical trials have demonstrated that the Patency capsule is a good tool for ... | 18,785,278 |
Halothane hepatitis in Iran: a review of 59 cases. | To study halothane hepatitis (HH) in Iran and its associated risk factors. We retrospectively studied files of all cases diagnosed with HH referred to three referral hospitals and four private centers in Iran from April 1994 to September 2006. Information on age at surgery, gender, medications history, obesity, history... | 18,785,286 |
Effect of music on procedure time and sedation during colonoscopy: a meta-analysis. | To integrate results from different studies in examining the effectiveness of music in reducing the procedure time and the amount of sedation used during colonoscopic procedure. An electronic search in various databases was performed to identify related articles. Study quality was evaluated by the Jadad's scale. The ra... | 18,785,289 |
Effect of mutant p27(kipl) gene on human cholangiocarcinoma cell line, QBC(939). | To investigate the effects of exogenously mutated p27(kipl) (p27) on proliferation and apoptosis of human cholangiocarcinoma cell line, QBC(939)in vivo. Adenviral vectors were used to transfect mutated p27 cDNA into human QBC(939)cell line. Expression of p27 was detected by RT-PCR. Western blot. Cell growth, morphologi... | 18,785,290 |
Functional polymorphisms of folate-metabolizing enzymes in relation to homocysteine concentrations in systemic lupus erythematosus. | To determine if functional polymorphisms of folate/homocysteine pathway enzymes are associated with homocysteine concentrations and/or coronary artery calcification (CAC) scores in patients with systemic lupus erythematosus (SLE) and controls. We investigated 163 SLE patients and 160 controls. Functional polymorphisms ... | 18,785,313 |
Dismissing the disgruntled: Swedish patient complaints management. | Over the past decade the Swedish system for dealing with patient complaints has come under increasingly intense scrutiny from both healthcare providers and consumers. This article summarizes contemporary Swedish viewpoints on the debate by using sociological theory combined with anthropological field data. Its purpose ... | 18,785,347 |
Comparison of the effects of a home-based and group-based resistance training program on functional ability in older adults. | To compare the effectiveness of home- and group-based, progressive resistance training programs and a group walking program in improving functional performance in older adults. A quasi-experimental trial, in which retirement villages were assigned to one of three groups: home-based resistance training, group-based resi... | 18,785,369 |
Tobacco use assessment: what exactly is your patient using and why is it important to know? | This article was presented as part of the 2007 International Society on Hypertension in Blacks (ISHIB) lifestyle modification workshop focusing on smoking cessation. The three objectives addressed included 1) identification of the known and little-known health effects of cigarette smoking (eg, endocrine effects on the ... | 18,785,400 |
Safety and efficacy of intra-articular sodium hyaluronate (Hyalgan) in a randomized, double-blind study for osteoarthritis of the ankle. | The potential benefit of hyaluronans in alleviating pain associated with osteoarthritis (OA) in joints other than the knee is of increasing interest. This double-blind, randomized, controlled study examined the safety and efficacy of intraarticular sodium hyaluronate (Hyalgan) in the treatment of pain associated with a... | 18,785,414 |
Acute and overuse injuries correlated to hours of training in master running athletes. | The goal of the study was to determine the rate of running-associated tendinopathy in light of the amount of time training and other risk factors. 291 elite runners (average age 42 +/- 9 years) who ran an average of 65.2 +/- 28.3 km/week were included with an overall distance of 9,980,852 km (34,416 km/athlete). Descri... | 18,785,416 |
Changes in length of the first ray with two different first MTP fusion techniques: a cadaveric study. | First metatarsophalangeal joint (MTP) fusions are performed as salvage procedures for a variety of conditions ranging from osteoarthritis, rheumatoid arthritis, hallux valgus, and failed first MTP arthroplasty. A number of bone preparation techniques have been described to fuse the first MTP joint, with varying degrees... | 18,785,423 |
The role of expectations in patient assessments of hospital care: an example from a university hospital network, Turkey. | The aim of this paper is to document a study, in which the SERVQUAL scale was used to evaluate hospital services, conducting a preliminary assessment of patient attitudes regarding the important aspects of service dimensions. The SERVQUAL scale was implemented into routine use at the Baskent University Hospitals Networ... | 18,785,460 |
[Construction of RevS gene knock-out mutant of Streptococcus suis serotype 2]. | To construct a gene knock-out mutant of response regulator named RevS in Streptococcus suis serotype 2 virulent strain 05ZYH33, and to investigate the effects of its deletion on the biological characters of this pathogen and the pathogenesis to mice and piglets. Recombinant gene knock-out vector consisting of Spc(r) ca... | 18,785,481 |
[Comparison of ultrasound biomicroscopy and CT in diagnosis of anterior segment intraocular foreign body]. | To report the appearance of anterior segment intraocular foreign body in ultrasound biomicroscopy (UBM) and CT. To investigate the advantage and disadvantage of these two imaging methods and to evaluate the value of combining application of these methods in the diagnosis of anterior segment intraocular foreign body. It... | 18,785,546 |
[Clinical analysis of 73 cases of macrodactyly]. | To analyze the clinical characteristics of 73 cases of macrodactyly. Review the incidence, distribution, characteristic, X-rays, pathogenesis and treatment of involved digits on the base of the clinical documents of 73 macrodactyly which were treated from 1965 to 2006. Twenty-eight cases had been followed-up. Unilatera... | 18,785,561 |
[Injuries after lobectomy: a prospective randomized comparison of video-assisted thoracoscopic surgery and mini-thoracotomy]. | To compare the differences of injuries and recovery between video-assisted thoracoscopic surgery (VATS) and mini-thoracotomy (MT) in patients with clinical early stage non-small cell lung cancer (NSCLC) after lobectomy. From March 2004 to December 2006, 47 consecutive patients with early stage NSCLC with a diameter of ... | 18,785,569 |
[Acute mesenteric venous thrombosis: experience of 27 cases]. | To summarize the diagnostic and therapeutic experiences of acute mesenteric venous thrombosis (MVT). The clinical data of 27 cases of acute MVT treated between 1983 and July 2007 were analyzed retrospectively. The courses of disease were from 1 to 14 days (mean, 6.1 days). Eighteen cases (66.7%) had the history of port... | 18,785,575 |
Molecular phylogeny of pneumocystis based on 5.8S rRNA gene and the internal transcribed spacers of rRNA gene sequences. | To clarify the phylogenetic relationships and species status of Pneumocystis, the 5.8S rRNA gene and the internal transcribed spacers (ITS, 1 and 2) of Pneumocystis rRNA derived from rat, gerbil and human were amplified, cloned and sequenced. The genetic distance matrix of six Pneumocystis species compared with other f... | 18,785,590 |
Study on the interaction between palladium(II)-lincomycin chelate and erythrosine by absorption, fluorescence and resonance Rayleigh scattering spectra and its analytical applications. | In pH 5.0-5.4 HAc-NaAc buffer solution, lincomycin (Linco) reacted with Pd(II) to form 1:1 cationic chelate, which could further react with erythrosine (Ery) to form 1:1 ion-association complexes (Pd-Linco)Ery. As a result, not only were the absorption and fluorescence spectra changed, but also the resonance Rayleigh s... | 18,785,616 |
Effectiveness of saliva collection and enzyme-immunoassay for the quantification of cortisol in socially housed baboons. | Circulating cortisol levels are often used to assess the biological stress response in captive primates. Some methods commonly used to collect blood samples may alter the stress response. As such, noninvasive means to analyze cortisol levels are increasingly being developed. We adapted an existing collection method to ... | 18,785,637 |
Using the CORE-R battery in group psychotherapy. | This article applies and illustrates the American Group Psychotherapy Association (AGPA) revised CORE battery to daily practice. The CORE can assist practitioners in periodically or continuously monitoring outcome and process factors to determine patient status (e.g., improved, deteriorated, or no change), and ruptures... | 18,785,650 |
Retracted: A catechol type siderophore, bacillibactin: biosynthesis, regulation and transport in Bacillus subtilis. | Retraction: The following article from the Journal of Basic Microbiology, "A catechol type siderophore, bacillibactin: biosynthesis, regulation and transport in Bacillus subtilis" by Waseem Raza, Hongsheng Wu, Muhammad Ali Abdullah Shah and Qirong Shen, published online on 11 September 2008 in Wiley InterScience (www.i... | 18,785,660 |
Molecular mechanisms causing anomalously high thermal expansion of nanoconfined water. | Anomalously high thermal expansion is measured in water confined in nanoscale pores in amorphous silica and the molecular mechanisms are identified by molecular dynamics (MD) simulations using an accurate dissociative water potential. The experimentally measured coefficient of thermal expansion (CTE) of nanoconfined wa... | 18,785,675 |
The role of crystallization parameters for the synthesis of germanosilicate with UTL topology. | The investigation of the critical synthesis parameters of germanosilicate of UTL topology, possessing 14- and 12-rings, has been carried out in detail. (6R,10S)-6,10-Dimethyl-5-azoniaspiro[4.5]decane hydroxide was used as the structure-directing agent (SDA). The kinetics of the synthesis, the role of the Si/Ge ratio in... | 18,785,677 |
Adsorption and structure of water on kaolinite surfaces: possible insight into ice nucleation from grand canonical monte carlo calculations. | Grand canonical Monte Carlo calculations are used to determine water adsorption and structure on defect-free kaolinite surfaces as a function of relative humidity at 235 K. This information is then used to gain insight into ice nucleation on kaolinite surfaces. Results for both the SPC/E and TIP5P-E water models are co... | 18,785,690 |
Spectroscopic characterization of phenazinium dye aggregates in water and acetonitrile media: effect of methyl substitution on the aggregation phenomenon. | Absorption, fluorescence, and fluorescence excitation spectral studies of two planar, cationic phenazinium dyes, namely, phenosafranin (PSF) and safranin-T (ST), have been performed in protic and aprotic polar solvents. The studies reveal the formation of both J- and H-aggregates in concentrated solutions. The planarit... | 18,785,692 |
Study of film structure and adsorption kinetics of polyelectrolyte multilayer films: effect of pH and polymer concentration. | The alternate adsorption of polycation poly(allylamine hydrochloride)(PAH) and the sodium salt of the polymeric dye poly(1-[ p-(3'-carboxy-4'-hydroxyphenylazo)benzenesulfonamido]-1,2-ethandiyl)(PCBS) on quartz crystals coated with silica was studied to understand the structural properties and adsorption kinetics of the... | 18,785,708 |
Raman enhancement of azobenzene monolayers on substrates prepared by Langmuir-Blodgett deposition and electron-beam lithography techniques. | Nanostructured metallic platforms for Raman enhancement were fabricated using Langmuir-Blodgett and electron beam (e-beam) lithography techniques. The gold platforms were inscribed on thin glass slides with the purpose of using them in a transmission geometry experimental setup under a confocal microscope. The plasmon ... | 18,785,712 |
Mannose-based molecular patterns on stealth microspheres for receptor-specific targeting of human antigen-presenting cells. | The targeting of antigen-presenting cells has recently gained strong attention for both targeted vaccine delivery and immunomodulation. We prepared surface-modified stealth microspheres that display various mannose-based ligands at graded ligand densities to target phagocytic C-type lectin receptors (CLRs) on human den... | 18,785,716 |
Electrochemical synthesis of silver polyhedrons and dendritic films with superhydrophobic surfaces. | Single-crystalline Ag dendrites are grown on a Ni/Cu substrate by using a simple templateless, surfactantless electrochemical technique. Controlling only the applied potential causes a change in the deposited silver morphology from polyhedrons to dendrites. Microstructure characterization suggests that preferential gro... | 18,785,717 |
Self-associative behavior and drug-solubilizing ability of poloxamine (tetronic) block copolymers. | The incidence of the structural features on the self-assembly of different poloxamines (the conventional sequential Tetronic 304, 901, 904, 908, 1107, 1301, and 1307; a reverse-sequential counterpart Tetronic 150R1; and a chemically modified derivative, N-methylated Tetronic 1107) was thoroughly studied in 10 mM HCl by... | 18,785,722 |
In vivo positron emission tomography (PET) imaging with an alphavbeta6 specific peptide radiolabeled using 18F-"click" chemistry: evaluation and comparison with the corresponding 4-[18F]fluorobenzoyl- and 2-[18F]fluoropropionyl-peptides. | Numerous radiolabeled peptides have been utilized for in vivo imaging of a variety of cell surface receptors. For applications in PET using [(18)F]fluorine, peptides are radiolabeled via a prosthetic group approach. We previously developed solution-phase (18)F-"click" radiolabeling and solid-phase radiolabeling using 4... | 18,785,727 |
Discovery of inhibitors of Escherichia coli methionine aminopeptidase with the Fe(II)-form selectivity and antibacterial activity. | Methionine aminopeptidase (MetAP) is a promising target to develop novel antibiotics, because all bacteria express MetAP from a single gene that carries out the essential function of removing N-terminal methionine from nascent proteins. Divalent metal ions play a critical role in the catalysis, and there is an urgent n... | 18,785,729 |
Decarboxylative allylation using sulfones as surrogates of alkanes. | Alpha-sulfonyl functional groups are traceless activating groups that facilitate catalytic decarboxylative allylations in high yield yet can be cleaved to allow the synthesis of simple allylated alkanes. Substrate studies suggest that decarboxylation to form an alpha-sulfonyl anion is rate-limiting. Furthermore, the an... | 18,785,744 |
A novel beta-defensin structure: a potential strategy of big defensin for overcoming resistance by Gram-positive bacteria. | Big defensin is a 79-residue peptide derived from hemocytes of the Japanese horseshoe crab. It has antimicrobial activities against Gram-positive and -negative bacteria. The amino acid sequence of big defensin can be divided into an N-terminal hydrophobic half and a C-terminal cationic half. Interestingly, the trypsin ... | 18,785,751 |
Direct probe-atmospheric pressure chemical ionization mass spectrometry of cross-linked copolymers and copolymer blends. | Complex copolymers are heated to slowly increasing temperatures on a direct probe (DP) inside the plasma of the atmospheric pressure chemical ionization (APCI) source of a quadrupole ion trap. Slow heating allows for temporal separation of the thermal degradation products according to the stabilities of the bonds being... | 18,785,760 |
Rhodotorula infection. A systematic review of 128 cases from literature. | Rhodotorula is an emerging opportunistic pathogen, particularly in immunocompromised patients. Many cases of fungemia associated with catheters, endocarditis, peritonitis, meningitis, and endophthalmitis are infections incited by this yeast. The main purpose of this study was to review all cases of Rhodotorula infectio... | 18,785,780 |
Occurrence of fungi and mycotoxins in corn silage, Jalisco State, Mexico. | The aim of this study was to evaluate the chemical composition, mold count and mycotoxin contamination of corn silage collected during a six month-period. The results indicated that the chemical composition and the physicochemical parameters evaluated did not show significant variation during the sampling time. Fungal ... | 18,785,791 |
Improved splicing of adeno-associated viral (AAV) capsid protein-supplying pre-mRNAs leads to increased recombinant AAV vector production. | Adeno-associated viral (AAV) capsid proteins, thought to be a rate-limiting step in the production of recombinant AAV (rAAV), are translated from spliced mRNAs. Improvement of the native AAV nonconsensus donor sequence increases splicing yet leaves the relative levels of VP1- and VP2/3-encoding mRNAs unchanged, and thu... | 18,785,816 |
Evolution of intracellular pathogens. | The evolution of intracellular pathogens is considered in the context of ambiguities in basic definitions and the diversity of host-microbe interactions. Intracellular pathogenesis is a subset of a larger world of host-microbe interactions that includes amoeboid predation and endosymbiotic existence. Intracellular path... | 18,785,836 |
Cell biology of HIV-1 infection of macrophages. | HIV infection of macrophages is a critically important component of viral pathogenesis and progression to AIDS. Although the virus follows the same life cycle in macrophages and T lymphocytes, several aspects of the virus-host relationship are unique to macrophage infection. Examples of these are the long-term persiste... | 18,785,842 |
Study of autonomic nervous activity of night shift workers treated with laser acupuncture. | The aim of this study was to evaluate the impact of laser acupuncture on the autonomic nervous system (ANS) of the night shift worker. Many articles have demonstrated that levels of affective disorders and stress are high in night shift workers. We applied laser energy to the Neiguan point (PC6) to examine the impact o... | 18,785,846 |
Angiotensin II modulates CD40 expression in vascular smooth muscle cells. | The signalling pathway CD40/CD40L (CD40 ligand) plays an important role in atherosclerotic plaque formation and rupture. AngII (angiotensin II), which induces oxidative stress and inflammation, is also implicated in the progression of atherosclerosis. In the present study, we tested the hypothesis that AngII increases ... | 18,785,879 |
Role of hydrogen peroxide in competition and cooperation between Streptococcus gordonii and Actinomyces naeslundii. | In dental plaque alpha-haemolytic streptococci, including Streptococcus gordonii, are considered beneficial for oral health. These organisms produce hydrogen peroxide (H(2)O(2)) at concentrations sufficient to kill many oral bacteria. Streptococci do not produce catalase yet tolerate H(2)O(2). We recently demonstrated ... | 18,785,881 |
Tolterodine immediate release improves sexual function in women with overactive bladder. | Quality of life studies indicate that overactive bladder (OAB) has a greater negative impact on everyday life than other serious conditions such as diabetes. The detrimental effect of OAB on female sexual health is more prominent than urinary incontinence. We know that tolterodine immediate release (IR) has a beneficia... | 18,785,896 |
Sulfur starvation in rice: the effect on photosynthesis, carbohydrate metabolism, and oxidative stress protective pathways. | Sulfur-deficient plants generate a lower yield and have a reduced nutritional value. The process of sulfur acquisition and assimilation play an integral role in plant metabolism, and response to sulfur deficiency involves a large number of plant constituents. Rice (Oryza sativa) is the second most consumed cereal grain... | 18,785,901 |
Tradition in transition--intergenerational relations with focus on the aged and their family members in a South African context. | This study describes the intergenerational relations influence on the care of the aged in a transitional period expressed by a group of aged South Africans and their family members. Focused ethnographic research was carried out from 2001 to 2006 in a semi-rural area in central South Africa. Twenty-nine participants rep... | 18,785,915 |
Non-enzymatic developmental functions of acetylcholinesterase--the question of redundancy. | Despite in vitro demonstrations of non-enzymatic morphogenetic functions in acetylcholinesterase (AChE), the AChE knockout phenotype is milder than might be expected, casting doubt upon the relevance of such functions in vivo. Functional redundancy is a possible explanation. Using in vitro findings that AChE is able to... | 18,785,927 |
Characterization of inhibitory mechanism and antifungal activity between group-1 and group-2 phytocystatins from taro (Colocasia esculenta). | Tarocystatin from Colocasia esculenta, a group-2 phytocystatin, is a defense protein against phytopathogenic nematodes and fungi. It is composed of a highly conserved N-terminal region, which is homological to group-1 cystatin, and a repetitive peptide at the C-terminus. The purified recombinant proteins of tarocystati... | 18,785,929 |
Discontinuous drug combination therapy in autoimmune ocular disorders. | This study aimed to assess the effectiveness of a steroid-sparing immunosuppressive treatment (IST) protocol in the control of severe or steroid-resistant autoimmune ocular inflammatory diseases. We carried out a prospective, non-randomized clinical study. Patients presenting with ocular inflammations that failed to re... | 18,785,963 |
Serum thymus and activation regulated chemokine levels post-lung transplantation as a predictor for the bronchiolitis obliterans syndrome. | The main reason for mortality after lung transplantation is the bronchiolitis obliterans syndrome (BOS), which represents chronic rejection. As soluble CD30, which is produced mainly by activated T helper 2 (Th2) cells, was shown to be related to development of BOS, we aimed to investigate the relation between developm... | 18,785,972 |
Attenuation of monocyte proinflammatory cytokine responses to Neisseria meningitidis in children by erythropoietin. | Meningococcal disease is a leading infectious cause of death in children in industrialized countries. The induction of high levels of proinflammatory cytokines has been implicated in the pathogenesis of Neisseria meningitidis-related multi-organ failure. Here, we demonstrate that N. meningitidis serotypes A and B induc... | 18,785,973 |
Irritable bowel syndrome and dyspepsia among women veterans: prevalence and association with psychological distress. | The burden of functional GI disorders and their associations with psychological distress in women veterans is unclear. To examine 1-year prevalence of irritable bowel syndrome (IBS) and dyspepsia symptoms and their associations with anxiety, depression and post-traumatic stress disorder (PTSD) among women veterans rece... | 18,785,989 |
Dynamic behavior of Salmonella-induced membrane tubules in epithelial cells. | Salmonella Typhimurium is a facultative intracellular pathogen that causes acute gastroenteritis in man. Intracellular Salmonella survive and replicate within a modified phagosome known as the Salmonella-containing vacuole (SCV). The onset of intracellular replication is accompanied by the appearance of membrane tubule... | 18,785,994 |
Function of von Willebrand factor in haemostasis and thrombosis. | The physiological protection against bleeding is secured by platelet adhesion to the site of injury and sealing of the defect. The first step involves the arrest of platelets that have adhered to subendothelial structures, primarily collagen, at the site of injury. Under conditions of low shear rates, platelet adhesion... | 18,786,007 |
Caregiver burden among dementia patient caregivers: a review of the literature. | To identify current evidence of factors influencing dementia-related caregiver burden (CB), describe patient and caregiver characteristics associated with CB, and describe evidence-based interventions designed to lessen the burden of caregiving. Comprehensive literature review of Cumulative Index of Nursing and Allied ... | 18,786,017 |
Body mass index and nutritional intake in patients with HIV and chronic diarrhea: a secondary analysis. | The purpose of this study was to examine the differences in nutritional intake and body mass index (BMI) in HIV patients with chronic diarrhea via secondary analysis of patients' nutritional diaries. A secondary purpose was to evaluate the quality of diets against national dietary guidelines. Seventy-five ambulatory pa... | 18,786,023 |
Epidemiological characteristics of the 2002 outbreak of foot-and-mouth disease in the Republic of Korea. | The Republic of Korea experienced a foot-and-mouth disease (FMD) outbreak during May-June 2002. The present study describes epidemiological characteristics of the 2002 FMD outbreak in Korea, including the pattern of the outbreak in both time and space, transmission routes among infected farms, and control measures. One... | 18,786,074 |
Development of a self-management package for people with diabetes at risk of chronic kidney disease (CKD). | Kidney disease progression in diabetes can be slowed by strict blood pressure and blood sugar control, prescription of medicines that modify the renin-angiotensin system and lifestyle changes, such as smoking cessation. This paper describes the development of a self-management package for people with diabetes at risk o... | 18,786,082 |
Combating the illegal trade in African elephant ivory with DNA forensics. | International wildlife crime is burgeoning in this climate of global trade. We contend that the most effective way to contain this illegal trade is to determine where the wildlife is being removed. This allows authorities to direct law enforcement to poaching hot spots, potentially stops trade before the wildlife is ac... | 18,786,100 |
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