title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Refractory benign esophageal strictures: extending the role of expandable stents. | It is challenging to manage benign refractory esophageal strictures. We have now moved on from instant dilators to prolonged gradual dilatations using expandable stents that can be removed or biodegradable after a period of time left in situ. Recent published experience and the present study by Dua et al. have demonstr... | 18,786,109 |
Wireless pH recording immediately above the squamocolumnar junction improves the diagnostic performance of esophageal pH studies. | The optimal position for pH electrode placement in the diagnosis of gastroesophageal reflux disease (GERD) is unknown. The aim of this study was to evaluate the discriminatory power of targeted pH recording immediately above the squamocolumnar junction (SCJ) and to compare the results with those obtained by simultaneou... | 18,786,112 |
Transcription factors Sp1 and C/EBP regulate NRAMP1 gene expression. | The natural resistance-associated macrophage protein 1 (Nramp1), which belongs to a conserved family of membrane metal transporters, contributes to phagocyte-autonomous antimicrobial defense mechanisms. Genetic polymorphisms in the human NRAMP1 gene predispose to susceptibility to infectious or inflammatory diseases. T... | 18,786,141 |
Localization of general and regulatory proteolysis in Bacillus subtilis cells. | Protein degradation mediated by ATP-dependent proteases, such as Hsp100/Clp and related AAA+ proteins, plays an important role in cellular protein homeostasis, protein quality control and the regulation of, e.g. heat shock adaptation and other cellular differentiation processes. ClpCP with its adaptor proteins and othe... | 18,786,145 |
The porcine fat mass and obesity associated (FTO) gene is associated with fat deposition in Italian Duroc pigs. | In humans, common variants in the fat mass and obesity associated (FTO) gene are associated with body mass index and obesity. Here we sequenced exon 4, parts of introns 3 and 4 and two portions of the 3'-untranslated region of the porcine FTO gene in a panel of nine pigs of different breeds and identified three SNPs. A... | 18,786,155 |
Opioidergic regulation of astroglial/neuronal proliferation: where are we now? | Opiate drugs, such as codeine, morphine, and heroin, are powerful analgesics, but also are used as drugs of abuse because of their psychogenic properties. Many studies have shown that opiates impact on cellular proliferation in the adult and developing brain, although anatomical pathologies are lacking in in utero expo... | 18,786,168 |
Neuroprotective effect of sonic hedgehog up-regulated in Schwann cells following sciatic nerve injury. | The physiological roles of sonic hedgehog (Shh) have been intensively characterized in development of various organs. However, their functions in adult tissues have not been fully elucidated. We investigated the expression and the potential function of Shh in crush-injured adult rat sciatic nerves. The Shh expression w... | 18,786,173 |
VEGFR-2-mediated increased proliferation and survival in response to oxygen and glucose deprivation in PlGF knockout astrocytes. | In hypoxic/ischemic conditions, astrocytes are involved in neuroprotection and angiogenesis. Vascular endothelial growth factor (VEGF) induces angiogenesis and exhibits neuroprotective and neurotrophic properties. However, the role of placental growth factor (PlGF), a VEGF homolog, in these processes is unclear. Theref... | 18,786,179 |
Penile malignant melanoma in a hemodialysis patient. | A patient who was receiving hemodialysis treatment developed melanotic macules on the surface of the penis in 2002 and showed a tumor-like mass in the same region in July 2006. The patient presented with a pedunculated tumor of 3 cm in diameter on the right side of his penis. The tumor was resected for biopsy and was d... | 18,786,196 |
Personality disorders: illegitimate subject positions. | The diagnosis of personality disorder is common in mental health nurse settings and is a term often used without critical consideration. In clinical practice, the term personality disorder has pejorative connotations, which arise out of the way in which these behaviours are constructed as behavioural rather than psychi... | 18,786,214 |
Humanism in forensic psychiatry: the use of the tidal nursing model. | The humanist school of thought, which finds resonance in many conceptual models and theories designed to guide nursing practice, needs to be understood in the context of the total institution, where the individual is subjected to a mortification of the self, and denied autonomy. This article will engage in a critical r... | 18,786,215 |
Comparative risk of impaired glucose metabolism associated with cyclosporine versus tacrolimus in the late posttransplant period. | New onset diabetes after transplantation (NODAT) and impaired fasting glucose (IFG) are common in kidney transplant recipients (KTRs). Calcinuerin inhibitor (CNI) therapy is a causal risk factor. NODAT is associated with increased mortality and diminished graft survival. We studied the incidence of NODAT and IFG in KTR... | 18,786,231 |
Pressure support ventilation attenuates ventilator-induced protein modifications in the diaphragm. | Controlled mechanical ventilation (CMV) induces profound modifications of diaphragm protein metabolism, including muscle atrophy and severe ventilator-induced diaphragmatic dysfunction. Diaphragmatic modifications could be decreased by spontaneous breathing. We hypothesized that mechanical ventilation in pressure suppo... | 18,786,263 |
Computational detection of significant variation in binding affinity across two sets of sequences with application to the analysis of replication origins in yeast. | In analyzing the stability of DNA replication origins in Saccharomyces cerevisiae we faced the question whether one set of sequences is significantly enriched in the number and/or the quality of the matches of a particular position weight matrix relative to another set. We present SADMAMA, a computational solution to a... | 18,786,274 |
[The potential role of high mobility group box 1 protein in immune dysfunction and its regulatory mechanism after major trauma]. | To investigate the potential effect of high mobility group box 1 protein (HMGB1) on host immune response and its molecular regulation mechanism as well as its interventional pathway following major burns/trauma. With both animal experiments and clinical investigation, serial studies were conducted to observe the effect... | 18,786,304 |
[The relationship between dysfunction of cell-mediated immunity and prognosis in severely burned patients]. | To investigate the relationship between dysfunction of cell-mediated immunity and prognosis in severely burned patients. Twenty-six patients with total burn surface area larger than 70% total body surface area (TBSA) were included in the present study, and they were divided into non-survival group (14 cases) and surviv... | 18,786,305 |
Perspectives on the etiology of chronic rhinosinusitis: an immune barrier hypothesis. | Chronic rhinosinusitis (CRS) has been defined as persistent symptomatic inflammation of the nasal and sinus mucosa resulting from the interaction of multiple host and environmental factors. Recent studies have implicated Alternaria fungi or toxigenic Staphylococcus aureus as critical agents in CRS pathogenesis. The emp... | 18,786,300 |
How to implement incretin therapy. | The roles of glucagon-like peptide-1 (GLP-1) receptor agonists and dipeptidyl peptidase-4 (DPP-4) inhibitors are rapidly evolving, despite limited recommendations on their use in current guidelines. This evolution is based on data from the large number of clinical trials demonstrating the clinical efficacy and favorabl... | 18,786,341 |
[Not Available]. | Severe tooth wear is discussed from the perspective of appreciating the aetiologic background of the problem. A multifactorial basis is acknowledged for the extensively worn dentition and efforts to eliminate or minimize these underlying factors are important. The management of a case of severe incisal and occlusal wea... | 18,786,347 |
Scent of a fly. | Sexual courtship is a highly ritualized behavior in many animals. Recent work in the vinegar fly, Drosophila melanogaster, has illuminated how the pheromone cis-vaccenyl acetate modulates sexual behavior in the fly. Chemosensory receptors and a sexually dimorphic circuit activated by this pheromone have been identified... | 18,786,353 |
p73 regulates neurodegeneration and phospho-tau accumulation during aging and Alzheimer's disease. | The genetic mechanisms that regulate neurodegeneration are only poorly understood. We show that the loss of one allele of the p53 family member, p73, makes mice susceptible to neurodegeneration as a consequence of aging or Alzheimer's disease (AD). Behavioral analyses demonstrated that old, but not young, p73+/- mice d... | 18,786,355 |
Large-scale movement within the voltage-sensor paddle of a potassium channel-support for a helical-screw motion. | The size of the movement and the molecular identity of the moving parts of the voltage sensor of a voltage-gated ion channel are debated. In the helical-screw model, the positively charged fourth transmembrane segment S4 slides and rotates along negative counter charges in S2 and S3, while in the paddle model, S4 carri... | 18,786,360 |
New insights into ancient seasonal life timers. | Organisms must adapt to seasonal changes in the environment and time their physiology accordingly. In vertebrates, the annual change in photoperiod is often critical for entraining the neuroendocrine pathways, which drive seasonal metabolic and reproductive cycles. These cycles depend on thyroid hormone (TH), reflectin... | 18,786,385 |
Notch signaling specifies megakaryocyte development from hematopoietic stem cells. | In the hematopoietic system, Notch signaling specifies T cell lineage fate, in part through negative regulation of B cell and myeloid lineage development. However, we unexpectedly observed the development of megakaryocytes when using heterotypic cocultures of hematopoietic stem cells with OP9 cells expressing Delta-lik... | 18,786,418 |
A drug-inducible system for direct reprogramming of human somatic cells to pluripotency. | Current approaches to reprogram human somatic cells to pluripotent iPSCs utilize viral transduction of different combinations of transcription factors. These protocols are highly inefficient because only a small fraction of cells carry the appropriate number and stoichiometry of proviral insertions to initiate the repr... | 18,786,421 |
Recurrent der(9;18) in essential thrombocythemia with JAK2 V617F is highly linked to myelofibrosis development. | We studied JAK2 mutational status, in combination with cytogenetic analysis in 54 patients with essential thrombocythemia (ET), and attempted to obtain greater insight into the correlation between clinicohematologic features and genetic abnormalities. We found that six ET patients developed myelofibrosis and four of th... | 18,786,436 |
Distinct karyotypes in three breast cancer cell lines --21PTCi, 21NTCi, and 21MT-1 --derived from the same patient and representing different stages of tumor progression. | Three breast carcinoma cell lines --21PTCi, 21NTCi, and 21MT-1 --all originating from a 36-year-old woman with metastatic breast cancer, have been characterized previously as stably representing different stages of progression: (nontumorigenic [21PTCi]; tumorigenic, nonmetastatic [21NTCi]; and tumorigenic, weakly metas... | 18,786,440 |
Adherence to hand hygiene in an Italian long-term care facility. | In an Italian long-term-care facility (LTCF), we observed a 17.5% adherence to hand hygiene (HH), as well as 47.5% rate of glove use. Performing a procedure at high risk for cross-transmission of germs was the factor most strongly associated with noncompliance (odds ratio = 13.3; 95% confidence interval = 6.2 to 28.8; ... | 18,786,454 |
Protective effect of aspartate and glutamate on cardiac mitochondrial function during myocardial infarction in experimental rats. | The present study investigates the effect of aspartate and glutamate on mitochondrial function during myocardial infarction (MI) in wistar rats. Male albino wistar rats were pretreated with aspartate [100 mg(kgbody weight)(-1) day(-1)] or glutamate [100 mg(kg body weight)(-1) day(-1)] intraperitoneally for a period of ... | 18,786,522 |
Importance of the C-terminus of the human 5-HT3A receptor subunit. | Amongst the family members of Cys-loop LGICs, the atypical ability of the 5-HT3A subunit to form functional homomeric receptors allowed a direct investigation of the role of the C-terminus. Deletion of the three C-terminal amino acids (DeltaGln453-DeltaTyr454-DeltaAla455) from the h5-HT3A subunit prevented formation of... | 18,786,552 |
Indirubin-3'-oxime impairs mitochondrial oxidative phosphorylation and prevents mitochondrial permeability transition induction. | Indirubin, a red colored 3,2'-bisindole isomer, is a component of Indigo naturalis and is an active ingredient used in traditional Chinese medicine for the treatment of chronic diseases. The family of indirubin derivatives, such as indirubin-3'-oxime, has been suggested for various therapeutic indications. However, pot... | 18,786,556 |
The yeast lysosome-like vacuole: endpoint and crossroads. | Fungal vacuoles are acidic organelles with degradative and storage capabilities that have many similarities to mammalian lysosomes and plant vacuoles. In the past several years, well-developed genetic, genomic, biochemical and cell biological tools in S. cerevisiae have provided fresh insights into vacuolar protein sor... | 18,786,576 |
Impaired frontal synchronization of spontaneous magnetoencephalographic activity in patients with bipolar disorder. | Recent functional imaging studies demonstrated that brain exhibit coherent, synchronized activities during resting state and the dynamics may be impaired in various psychiatric illnesses. In order to investigate the change of neural dynamics in bipolar disorder, we used a new nonlinear measurement "similarity index" to... | 18,786,606 |
Calpastatin overexpression attenuates amyloid-beta-peptide toxicity in differentiated PC12 cells. | Amyloid beta peptide (Abeta) plays a major role in the pathogenesis of Alzheimer's disease (AD). Abeta is toxic to neurons, possibly through causing initial synaptic dysfunction and neuronal membrane dystrophy, promoted by increased cellular Ca(2+). Calpain (Ca(2+)-dependent protease) and caspase have been implicated i... | 18,786,620 |
Transfection activity of layer-by-layer plasmid DNA/poly(ethylenimine) films deposited on PLGA microparticles. | Layer-by-layer (LbL) assemblies of DNA and polycations on the surface of colloidal templates can be used for gene delivery. Plasmid DNA encoding for secreted alkaline phosphatase (SEAP) was used to deposit LbL films with poly(ethylenimine) (PEI) on the surface of polystyrene and poly(lactide-co-glycolide) microparticle... | 18,786,622 |
Microfluidic-based enzymatic on-chip labeling of miRNAs. | Small noncoding RNAs (sncRNAs) have moved from oddity to recognized important players in gene regulation. Next generation sequencing approaches discover more and more such molecules from a variety of different groups, but flexible tools translating this sequence information into affordable high-throughput assays are mi... | 18,786,664 |
In situ fabrication of silver nanoarrays in hyaluronan/PDDA layer-by-layer assembled structure. | We present a simple in situ method to fabricate silver (Ag) nanoparticle arrays in a layer-by-layer (LBL) assembled hyaluronan (HA)/poly(dimethyldiallylammonium chloride) (PDDA) multilayer structure, in which the LBL multilayered film is constructed by electrostatic attraction between positively charged PDDA and negati... | 18,786,677 |
Influence of pharmaceutical residues on the structure of activated sludge bacterial communities in wastewater treatment bioreactors. | Concern is growing over contamination of the environment with pharmaceuticals because of their widespread use and incomplete removal during wastewater treatment, where microorganisms drive the key processes. The influence of pharmaceuticals on bacterial community structure in activated sludge was assessed in small-scal... | 18,786,690 |
Changes in subpopulations of boar sperm defined according to viability and plasma and acrosome membrane status observed during storage at 15 degrees C. | Four boar ejaculates were preserved for 42d at 15 degrees C to examine the changes produced in the quality of sperm membranes according to their response to a combined short hypoosmotic swelling test (sHOST) plus viability test designated the sHV test. Every 1 or 2d, a sample from each ejaculate preserved in long-term ... | 18,786,721 |
Clinical correlates of depersonalization symptoms in patients with bipolar disorder. | Prevalence and clinical correlates of dissociative symptoms in general, and depersonalization (DP) in particular, in patients with mood disorders have received limited attention in the literature. Nevertheless, the identification of these symptoms may have important implications in terms of a better definition of clini... | 18,786,726 |
Expression of neurotrophin receptors by proliferating glia in postischemic hippocampal CA1 sector of adult monkeys. | Transient global cerebral ischemia elicits a nearly total neuronal cell death in the hippocampal CA1 sector, accompanied by a marked microglial and astroglial proliferation. The molecular mechanisms regulating the postischemic glial reaction in the primate brain remain obscure. Here we present in situ evidence that pro... | 18,786,730 |
Rat area postrema microglial cells act as sensors for the toll-like receptor-4 agonist lipopolysaccharide. | The area postrema (AP) represents the sensory circumventricular organ lacking endothelial blood-brain barrier function in direct vicinity to the 4th cerebral ventricle. Administration of lipopolysaccharide (LPS), as opposed to muramyldipeptide (MDP) or fibroblast-stimulating lipopeptide-1 (FSL-1), caused fast transient... | 18,786,731 |
Attenuated metabolic effect of waist measurement in Japanese female patients with type 2 diabetes mellitus. | Waist circumference (WC) was measured in 200 Japanese patients with type 2 diabetes mellitus (T2DM: male 106, female 94, mean age 61 years old) who had been admitted in our hospital, and relationship with various risk factors to predict future cardiovascular disease (CVD) was analyzed. There was a positive and statisti... | 18,786,739 |
Widespread conservation of genetic redundancy during a billion years of eukaryotic evolution. | Genetic redundancy means that two genes can perform the same function. Using a comprehensive phylogenetic analysis, we show here in both Saccharomyces cerevisiae and Caenorhabditis elegans that genetic redundancy is not just a transient consequence of gene duplication, but is often an evolutionary stable state. In mult... | 18,786,741 |
Randomized placebo-controlled trial assessing a treatment strategy consisting of pravastatin, vitamin E, and homocysteine lowering on plasma asymmetric dimethylarginine concentration in mild to moderate CKD. | Chronic kidney disease (CKD) is associated with an increased incidence of cardiovascular disease (CVD). The Anti-oxidant Therapy In Chronic Renal Insufficiency (ATIC) Study showed that a multistep treatment strategy improved carotid intima-media thickness, endothelial function, and microalbuminuria in patients with sta... | 18,786,751 |
Dentin tubule numerical density variations below the CEJ. | To evaluate dentin tubule numerical density variations below the CEJ. Three human non-carious permanent canines were sectioned parallel to the CEJ to obtain dentin disks 1mm thick whose surfaces were 1mm and 2mm below the CEJ. Each disk was sectioned into quarters resulting in four segment locations: facial, lingual, m... | 18,786,756 |
The effect of mifepristone on apoptosis and caspase-3 activation in human ovarian luteinized granulosa cells. | To investigate the effect of mifepristone, an oral contraceptive, on apoptosis in human ovarian luteinized granulosa cells. Human ovarian luteinized granulosa cells were treated in vitro with 1.25, 2.5, 5.0, 10.0, or 20.0 microM of mifepristone. Nuclear morphology, apoptosis ratio, and level of caspase-3 expression wer... | 18,786,757 |
Interaction of malachite green with bovine serum albumin: determination of the binding mechanism and binding site by spectroscopic methods. | The interaction between malachite green (MG) and bovine serum albumin (BSA) under simulative physiological conditions was investigated by the methods of fluorescence spectroscopy, UV-vis absorption and circular dichroism (CD) spectroscopy. Fluorescence data showed that the fluorescence quenching of BSA by MG was the re... | 18,786,760 |
The year in burns 2007. | In the year 2007, approximately 1000 original burn research articles were published in scientific journals using the English language. This article reviews approximately 90 of these which were deemed by the author to be the most important in terms of clinical burn care. Relevant topics include epidemiology, wound chara... | 18,786,767 |
Endoplasmic reticulum stress in beta cells: latent mechanism of secondary sulfonylurea failure in type 2 diabetes? | Sulfonylureas, by stimulating beta cell to secrete insulin, are still largely used for treatment of type 2 diabetic patients. More recently concern has been raised with respect to possible adverse effects associated with the use of these agents, like favoring beta cell apoptosis and beta cell exhaustion, which is belie... | 18,786,775 |
Rhinocerebral Mucormycosis: consideration of prognostic factors and treatment modality. | Rhinocerebral mucormycosis is rare, rapidly progressive, potentially life-threatening disease, and it usually occurs in immunocompromised patients. We present our clinical experience with 12 cases and we attempt to identify the prognostic features and proper treatment protocols. All the cases of mucormycosis were prove... | 18,786,790 |
Pattern recognition system for the discrimination of multiple sclerosis from cerebral microangiopathy lesions based on texture analysis of magnetic resonance images. | In this study, a pattern recognition system has been developed for the discrimination of multiple sclerosis (MS) from cerebral microangiopathy (CM) lesions based on computer-assisted texture analysis of magnetic resonance images. Twenty-three textural features were calculated from MS and CM regions of interest, delinea... | 18,786,795 |
[What should be known for the introduction of an HPV vaccine?]. | Genital human papillomavirus (HPV) infection is one of the most common sexually transmitted infections worldwide. Two HPV vaccines are now available in many countries: (i) the first vaccine is quadrivalent and indicated in the prevention of CIN 2/3, cervical cancers, VIN 2/3, VaIN 2/3 and genital warts associated with ... | 18,786,806 |
A theory-based cross-sectional survey demonstrated the important role of awareness in guideline implementation. | To assess physiotherapists' adherence to the Dutch guidelines for nonspecific low back pain, the motivational determinants related to guideline adherence, and the role of physiotherapists' awareness of their performance in this respect. This was a cross-sectional survey among a random sample of 1,500 private practice p... | 18,786,808 |
Taq1A polymorphism in the dopamine D2 receptor gene as a predictor of clinical response to aripiprazole. | We investigated whether the clinical response to aripiprazole differed according to the Taq1A polymorphism in the dopamine D2 receptor (DRD2) gene. In this 26-week, prospective, open-label, double-blind, parallel-group study, 90 patients with schizophrenia, schizoaffective disorder, or schizophreniform disorder were re... | 18,786,813 |
High-flexion implants in primary total knee arthroplasty: a meta-analysis. | We asked whether a high-flexion design implant improves patient functional outcomes or range of motion (ROM) after primary knee arthroplasty. We searched the major medical databases for randomized trials and comparison observational studies comparing high-flexion and conventional knee implants. After testing for public... | 18,786,829 |
Soft and hard tissue changes after bimaxillary surgery in Turkish female Class III patients. | Treatment of severe Class III malocclusion frequently requires a combination of orthodontics and orthognathic surgical procedures. The aims of this retrospective study were to assess the results of bimaxillary surgery on Turkish female subjects presenting with Class III malocclusions and to evaluate the correlation bet... | 18,786,833 |
Prevalence of Rickettsia species antibodies and Rickettsia species DNA in the blood of cats with and without fever. | Rickettsia species antibodies have been detected in some cats but it is unknown whether infected cats develop clinical signs. The prevalence of Rickettsia species deoxyribonucleic acid (DNA) in blood from clinically ill cats has not been determined. The objective of this study was to determine if cats with fever (body ... | 18,786,845 |
A new family of Ru(II) polypyridyl complexes containing open-chain crown ether for Mg2+ and Ca2+ probing. | Six polypyridyl bridging ligands BL(1-6) containing open-chain crown ether, where BL(1-3) formed by the condensation of 4,5-diazafluoren-9-hydrazine with 1,7-bis-(4-formylphenyl)-1,4,7-trioxaheptane, 1,10-bis-(4-formylphenyl)-1,4,7,10-tetraoxadecane, and 1,13-bis-(4-formylphenyl)-1,4,7,10,13-pentaoxatridecane, respecti... | 18,786,850 |
The unintended consequences of computerized provider order entry: findings from a mixed methods exploration. | To describe the foci, activities, methods, and results of a 4-year research project identifying the unintended consequences of computerized provider order entry (CPOE). Using a mixed methods approach, we identified and categorized into nine types 380 examples of the unintended consequences of CPOE gleaned from fieldwor... | 18,786,852 |
Links between eye movement preparation and the attentional processing of tactile events: an event-related brain potential study. | We investigated whether the covert preparation of saccadic eye movements results in spatially specific modulations of somatosensory processing. ERPs were recorded in a spatial cueing experiment where auditory cues preceded tactile stimuli delivered to the left or right hand. In the Saccade task, cues signalled that an ... | 18,786,857 |
Candidate gene polymorphisms and the 9p21 locus in acute coronary syndromes. | It is now widely accepted that the classic environmental risk factors for atherosclerosis only partly explain the incidence of coronary artery disease and the development of acute coronary syndromes. Therefore, genetic factors that vary among human populations seem to be involved in the clinical manifestations of such ... | 18,786,860 |
Inverse coupling between respiratory and cardiac oscillators in a life-threatening event in a neonate. | The authors report the case of a baby boy born at a gestational age of 32 weeks who experienced a life-threatening event triggered by vagal overactivity, associated with a transient phase of inverse coupling with a 1:1 phase ratio between ECG and respiration, resulting in respiratory arrest. This case report highlights... | 18,786,867 |
Longitudinal changes in quality of life and costs in long-term survivors of tumors of the oropharynx treated with brachytherapy or surgery. | Based on earlier studies we were interested in finding out if longitudinal assessment of quality of life (QoL) and costs in long-term survivors of oropharyngeal cancers treated with external beam radiation therapy and brachytherapy (BT) or surgery and postoperative radiotherapy showed a change in QoL over the years. Be... | 18,786,864 |
[Non-verbal communication in Alzheimer's disease]. | This review underlines the importance of non-verbal communication in Alzheimer's disease. A social psychological perspective of communication is privileged. Non-verbal behaviors such as looks, head nods, hand gestures, body posture or facial expression provide a lot of information about interpersonal attitudes, behavio... | 18,786,877 |
Psychiatriform disorders: psychiatric analogues of somatoform disorders. | Somatoform disorders can be understood to mimic supposedly more 'legitimate' physical disorders. To the extent that mental disorders are now also often considered legitimate, might clinicians expect to encounter the psychiatric equivalent of somatoform disorders, 'psychiatriform disorders'? The relevant literature on s... | 18,786,901 |
The relationship between staff members' working conditions and patients' perceptions of the treatment environment. | The psychosocial climate of inpatient units has proved to be related to both patient satisfaction and outcome. The aims of the study were twofold: to study the relationship between patient and staff satisfaction, and to study the relationship between the patients' perception of the treatment environment and the perceiv... | 18,786,905 |
Identification of a link between the SAMP repeats of adenomatous polyposis coli tumor suppressor and the Src homology 3 domain of DDEF. | The adenomatous polyposis coli (APC) tumor suppressor protein is a multifunctional protein with a well characterized role in the Wnt signal transduction pathway and in cytoskeletal regulation. The SAMP repeats region of APC, an Axin-binding site, is known to be important for tumor suppression and for the developmental ... | 18,786,926 |
Interaction between S100A8/A9 and annexin A6 is involved in the calcium-induced cell surface exposition of S100A8/A9. | The calcium binding S100A8/A9 complex (MRP8/14; calgranulin) is considered as an important proinflammatory mediator in acute and chronic inflammation and has recently gained attention as a molecular marker up-regulated in various human cancers. Here, we report that S100A8/A9 is expressed in breast cancer cell lines and... | 18,786,929 |
Factors affecting outcome of punctoplasty surgery: a review of 205 cases. | We reviewed retrospectively the indications, surgical techniques and outcomes of punctoplasty surgery for 205 consecutive patients in order to identify factors that influence success. We identified all patients who underwent punctoplasty surgery from April 2002 to June 2006 within the Royal Berkshire NHS Trust, UK. No ... | 18,786,958 |
IL-6 trans-signalling directly induces RANKL on fibroblast-like synovial cells and is involved in RANKL induction by TNF-alpha and IL-17. | We investigated the influence of cytokines on the expression of RANK ligand (RANKL) in fibroblast-like synoviocytes from RA patients (RA-FLS). RA-FLS were stimulated by IL-6, TNF-alpha, IL-17 and IL-1beta with or without soluble IL-6 receptor (sIL-6R) for 24 h. The expression of RANKL was measured by real-time PCR, wes... | 18,786,965 |
Adherence to Mediterranean diet and health status: meta-analysis. | To systematically review all the prospective cohort studies that have analysed the relation between adherence to a Mediterranean diet, mortality, and incidence of chronic diseases in a primary prevention setting. Meta-analysis of prospective cohort studies. English and non-English publications in PubMed, Embase, Web of... | 18,786,971 |
Adventitial transplantation of blood outgrowth endothelial cells in porcine haemodialysis grafts alleviates hypoxia and decreases neointimal proliferation through a matrix metalloproteinase-9-mediated pathway--a pilot study. | Purpose. We hypothesized that adventitial transplantation of blood outgrowth endothelial cells (BOEC) to the vein-to-graft anastomosis of polytetrafluoroethylene grafts will reduce neointimal hyperplasia by reducing hypoxia inducible factor-1alpha (HIF-1alpha), by increasing angiogenesis in a porcine model of chronic r... | 18,786,975 |
Can medical students identify recreational drugs by name? | Recreational drug toxicity is a common reason for presentation to the Emergency Department. Knowledge of recreational drug names is important to allow targeted assessment of patients presenting with recreational drug toxicity. To assess final year medical student knowledge of proper and street names for recreational dr... | 18,786,980 |
Group A human rotavirus genomics: evidence that gene constellations are influenced by viral protein interactions. | Group A human rotaviruses (HRVs) are the major cause of severe viral gastroenteritis in infants and young children. To gain insight into the level of genetic variation among HRVs, we determined the genome sequences for 10 strains belonging to different VP7 serotypes (G types). The HRVs chosen for this study, D, DS-1, P... | 18,786,998 |
Engineered expression of the TLR5 ligand flagellin enhances paramyxovirus activation of human dendritic cell function. | The paramyxovirus simian virus 5 (SV5) is a poor activator of human dendritic cell (DC) maturation pathways in vitro, and infected DC do not upregulate cell surface costimulatory proteins or secretion of immunomodulatory cytokines. We evaluated the hypothesis that activation of SV5-infected DC would be enhanced by engi... | 18,787,007 |
Impact of epitope specificity and precursor maturation in pro-B-type natriuretic peptide measurement. | Cardiac-derived natriuretic peptides are sensitive plasma markers of cardiac dysfunction. Recent reports have disclosed a more complex molecular heterogeneity of B-type natriuretic peptide precursor (proBNP)-derived peptides than previously suggested. In this study, we examined the impact of epitope specificity and pre... | 18,787,017 |
The role of redox signaling in cardiac hypertrophy induced by experimental hyperthyroidism. | This study was conducted to test whether oxidative stress activates the intracellular protein kinase B (AKT1) signaling pathway, which culminates with cardiac hypertrophy in experimental hyperthyroidism. Male Wistar rats were divided into four groups: control, vitamin E, thyroxine (T(4)), and T(4)+vitamin E. Hyperthyro... | 18,787,053 |
Canalicular Mrp2 localization is reversibly regulated by the intracellular redox status. | Oxidative stress is known to be a common feature of cholestatic syndrome. We have described the internalization of multidrug resistance-associated protein 2 (Mrp2), a biliary transporter involved in bile salt-independent bile flow, under acute oxidative stress, and a series of signaling pathways finally leading to the ... | 18,787,061 |
Secreted bioactive factors from Bifidobacterium infantis enhance epithelial cell barrier function. | Live probiotic bacteria are effective in reducing gut permeability and inflammation. We have previously shown that probiotics release peptide bioactive factors that modulate epithelial resistance in vitro. The objectives of this study were to determine the impact of factors released from Bifidobacteria infantis on inte... | 18,787,064 |
Age-dependent FOXO regulation of p27Kip1 expression via a conserved binding motif in rat muscle precursor cells. | Previously, we have demonstrated that forkhead box O3a (FOXO3a) overexpression increased p27(Kip1) promoter activity and protein expression, whereas it decreased proliferation in muscle precursor cells (MPCs). The objectives of the present study were to 1) locate and identify FOXO regulatory elements in the rat p27(Kip... | 18,787,071 |
Oxidant-induced inhibition of the plasma membrane Ca2+-ATPase in pancreatic acinar cells: role of the mitochondria. | Impairment of the normal spatiotemporal pattern of intracellular Ca(2+) ([Ca(2+)](i)) signaling, and in particular, the transition to an irreversible "Ca(2+) overload" response, has been implicated in various pathophysiological states. In some diseases, including pancreatitis, oxidative stress has been suggested to med... | 18,787,078 |
Eccentric contractions do not induce rhabdomyolysis in malignant hyperthermia susceptible mice. | Recent studies suggest a link between exercise-induced rhabdomyolysis and mutations of the ryanodine receptor (RYR1) associated with malignant hyperthermia (MH). We hypothesized that MH-susceptible mice (RYR1Y522S/wt) would exhibit greater anterior crural muscle [tibialis anterior (TA) and extensor digitorum longus (ED... | 18,787,086 |
Heme oxygenase-1 prevents airway mucus hypersecretion induced by cigarette smoke in rodents and humans. | We investigated the role of heme oxygenase-1 (HO-1), a powerful anti-inflammatory and anti-oxidant enzyme, in modulating cigarette smoke (CS)-induced mucus secretion. In both rats and mice, 5-day CS exposure increased HO-1 expression and activity, mucus secretion, MUCIN 5AC (MUC5AC) gene and protein expression, and loc... | 18,787,101 |
Tumor recovery by angiogenic switch from sprouting to intussusceptive angiogenesis after treatment with PTK787/ZK222584 or ionizing radiation. | Inhibitors of angiogenesis and radiation induce compensatory changes in the tumor vasculature both during and after treatment cessation. To assess the responses to irradiation and vascular endothelial growth factor-receptor tyrosine kinase inhibition (by the vascular endothelial growth factor tyrosine kinase inhibitor ... | 18,787,105 |
The membrane repair response masks membrane disturbances caused by cell-penetrating peptide uptake. | Although cell-penetrating peptides are able to deliver cargo into cells, their uptake mechanism is still not fully understood and needs to be elucidated to improve their delivery efficiency. Herein, we present evidence of a new mechanism involved in uptake, the membrane repair response. Recent studies have suggested th... | 18,787,109 |
Quantum chemical 13C(alpha) chemical shift calculations for protein NMR structure determination, refinement, and validation. | A recently determined set of 20 NMR-derived conformations of a 48-residue all-alpha-helical protein, (PDB ID code 2JVD), is validated here by comparing the observed (13)C(alpha) chemical shifts with those computed at the density functional level of theory. In addition, a recently introduced physics-based method, aimed ... | 18,787,110 |
Quantitative visualization of passive transport across bilayer lipid membranes. | The ability to predict and interpret membrane permeation coefficients is of critical importance, particularly because passive transport is crucial for the effective delivery of many pharmaceutical agents to intracellular targets. We present a method for the quantitative measurement of the permeation coefficients of pro... | 18,787,114 |
CD4 memory T cells divide poorly in response to antigen because of their cytokine profile. | Immunological memory is a hallmark of adaptive immunity, and understanding T cell memory will be central to the development of effective cell-mediated vaccines. The characteristics and functions of CD4 memory cells have not been well defined. Here we demonstrate that the increased size of the secondary response is sole... | 18,787,120 |
Modes of heme binding and substrate access for cytochrome P450 CYP74A revealed by crystal structures of allene oxide synthase. | Cytochrome P450s exist ubiquitously in all organisms and are involved in many biological processes. Allene oxide synthase (AOS) is a P450 enzyme that plays a key role in the biosynthesis of oxylipin jasmonates, which are involved in signal and defense reactions in higher plants. The crystal structures of guayule (Parth... | 18,787,124 |
Atypical E2F activity restrains APC/CCCS52A2 function obligatory for endocycle onset. | The endocycle represents an alternative cell cycle that is activated in various developmental processes, including placental formation, Drosophila oogenesis, and leaf development. In endocycling cells, mitotic cell cycle exit is followed by successive doublings of the DNA content, resulting in polyploidy. The timing of... | 18,787,127 |
Distinct TRP channels are required for warm and cool avoidance in Drosophila melanogaster. | The ability to sense and respond to subtle variations in environmental temperature is critical for animal survival. Animals avoid temperatures that are too cold or too warm and seek out temperatures favorable for their survival. At the molecular level, members of the transient receptor potential (TRP) family of cation ... | 18,787,131 |
Comment on "A global map of human impact on marine ecosystems". | Halpern et al. (Reports, 15 February 2008, p. 948) integrated spatial data on 17 drivers of change in the oceans to map the global distribution of human impact. Although fishery catches are a dominant driver, the data reflect activity while impacts occur at different space and time scales. Failure to account for this s... | 18,787,153 |
Cooling, heating, generating power, and recovering waste heat with thermoelectric systems. | Thermoelectric materials are solid-state energy converters whose combination of thermal, electrical, and semiconducting properties allows them to be used to convert waste heat into electricity or electrical power directly into cooling and heating. These materials can be competitive with fluid-based systems, such as two... | 18,787,160 |
Imaging of transient structures using nanosecond in situ TEM. | The microstructure and properties of a material depend on dynamic processes such as defect motion, nucleation and growth, and phase transitions. Transmission electron microscopy (TEM) can spatially resolve these nanoscale phenomena but lacks the time resolution for direct observation. We used a photoemitted electron pu... | 18,787,163 |
Postseismic relaxation along the San Andreas fault at Parkfield from continuous seismological observations. | Seismic velocity changes and nonvolcanic tremor activity in the Parkfield area in California reveal that large earthquakes induce long-term perturbations of crustal properties in the San Andreas fault zone. The 2003 San Simeon and 2004 Parkfield earthquakes both reduced seismic velocities that were measured from correl... | 18,787,165 |
Expansion of T-cell receptor zeta dim effector T cells in acute coronary syndromes. | The T-cell receptor zeta (TCR zeta)-chain is a master sensor and regulator of lymphocyte responses. Loss of TCR zeta-chain expression has been documented during infectious and inflammatory diseases and defines a population of effector T cells (TCR zeta(dim) T cells) that migrate to inflamed tissues. We assessed the exp... | 18,787,188 |
Role of the ATP-binding cassette transporter Abcg2 in the phenotype and function of cardiac side population cells. | Recently, the side population (SP) phenotype has been introduced as a reliable marker to identify subpopulations of cells with stem/progenitor cell properties in various tissues. We and others have identified SP cells from postmitotic tissues, including adult myocardium, in which they have been suggested to contribute ... | 18,787,193 |
Novel fold of VirA, a type III secretion system effector protein from Shigella flexneri. | VirA, a secreted effector protein from Shigella sp., has been shown to be necessary for its virulence. It was also reported that VirA might be related to papain-like cysteine proteases and cleave alpha-tubulin, thus facilitating intracellular spreading. We have now determined the crystal structure of VirA at 3.0 A reso... | 18,787,201 |
Transformation by retroviral vectors of bone marrow-derived mesenchymal cells induces mitochondria-dependent cAMP-sensitive reactive oxygen species production. | Retroviral vectors are used in human gene therapy trials to stably introduce therapeutic genes in the genome of patients' cells. Their applicability, however, is frustrated by the limited viability of transformed cells and/or by risks linked to selection of oncogene-mutated clones. The reasons for these drawbacks are n... | 18,787,213 |
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