title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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[Isolated ACTH deficiency in a late onset case of hypogonadism (LOH) not diagnosed by examination in an internal medicine clinic]. | We present a case of isolated adrenocorticotrophic hormone (ACTH) deficiency (IAD) in a late onset hypogonadism (LOH) clinic, not diagnosed by examinations in internal medicine. A 54-year-old man showed body weight loss with severe appetite loss, general malaise and hypotension. He visited our clinic for a checkup for ... | 18,788,451 |
Modulation of cardiac contractility through endothelin-1 release and myocardial mast cell degranulation. | The aim of this study was to outline the consequences of a hypertonic saline-dextran-40 (HSD) infusion-induced peripheral flow stimulus on the ventricular function in closed-chest, pentobarbital-anesthetized dogs. We hypothesized that HSD-induced elevation in endothelin-1 (ET-1) and nitric oxide (NO) release can have a... | 18,788,466 |
[Long-term paratesticular leiomyosarcoma. Conceptual and literature review]. | To know the incidence and clinical and pathologic characteristics of the paratesticular leiomyosarcoma (LMS) with the contribution of a case of long evolution, studying the histopathologic criteria that must be valued for this type of tumours. A 73-year-old patient includes for study with scrotal tumour present left si... | 18,788,490 |
[Molecular typing of isolates from two dysentery outbreaks in Chengdu, through pulsed field gel electrophoresis technology]. | Using pulsed field gel electrophoresis (PFGE) and polymerase chain reaction (PCR) typing to analyze strains isolated from two outbreaks caused by Shigella sonnei and to trace the source of infection. Virulence genes ipaH and ial were detected by PCR and PFGE was used to subtype the isolates. Patterns were compared, usi... | 18,788,530 |
[Ultrasonographic fetal nasal bone assessment in prenatal screening for Down syndrome]. | To investigate the clinic value of ultrasonographic fetal nasal bone examination as a screening marker for Down syndrome (DS). The study was conducted in the First Affiliated Hospital of Sun Yat-sen University from Oct 2004 to Mar 2007. Two-dimensional ultrasound was used to assess the fetal nasal bone of 1863 normal p... | 18,788,563 |
[Clinical analysis of six cases of vaginal intraepithelial neoplasia]. | To investigate the clinical characteristics, diagnosis and treatment of vaginal intraepithelial neoplasia (VAIN). A retrospective study was made of 6 patients with VAIN, who were hospitalized at Peking Union Medical College Hospital from 1980 to 2006. Five cases had a history of hysterectomy, two of whom were because o... | 18,788,568 |
[Regional lymph nodes targetting with enrichment of polyphase liposome]. | To investigate the feasibility of regional lymph nodes targetting with enrichment of radioactive 99mTc-polyphase liposome of 5-fluorouracil (99mTc-FL, FL). 18 rabbits were randomly divided into 3 groups, 6 rabbits per group. All rabbits were injected hypodermally with of 99mTc-FL in the right and left big toe webs, 18.... | 18,788,628 |
[Relationship of ezrin protein expression to the carcinogenesis and prognosis of infitrating breast ductal carcinoma]. | To investigate the relationship of ezrin protein expression to the carcinogenesis and prognosis of infiltrating breast ductal carcinoma. S-P immunohistochemical staining was used to detect the ezrin protein expression in 88 patients with infiltrating ductal carcinoma, and in 54 patients with intraductal hyperplastic le... | 18,788,632 |
More daytime sleeping predicts less functional recovery among older people undergoing inpatient post-acute rehabilitation. | To study the association between sleep/wake patterns among older adults during inpatient post-acute rehabilitation and their immediate and long-term functional recovery Prospective, observational cohort study. Two inpatient post-acute rehabilitation sites (one community and one Veterans Administration). Older patients ... | 18,788,654 |
Eszopiclone improves overnight polysomnography and continuous positive airway pressure titration: a prospective, randomized, placebo-controlled trial. | To assess whether premedication with eszopiclone would improve sleep duration and continuity during polysomnography, thereby improving the quality of diagnostic and CPAP titration studies. Prospective, double-blinded, placebo-controlled trial Academic, multidisciplinary sleep center. 226 adult subjects undergoing polys... | 18,788,656 |
Initial experience and result of thoracoscopic and laparoscopic esophagectomy. | Conventional esophagectomy requires either a laparotomy or a thoracotomy. Currently, the minimally invasive esophagectomy is an evolving alternative to the open technique. Assess and evaluate the early outcomes of the authors' experiences with the minimally invasive esophagectomy for esophageal cancer. Outcome data wer... | 18,788,691 |
Biochemical and spectroscopic characterization of morning glory peroxidase from an invasive and hallucinogenic plant weed Ipomoea carnea. | A novel heme peroxidase MGP from the latex of Ipomoea carnea subsp. fistulosa (morning glory) belonging to the Convolvulaceae family was purified to homogeneity using ammonium sulfate precipitation, anion exchange, hydrophobic interaction, and gel filtration chromatography. The enzyme is glycosylated and has a molecula... | 18,788,710 |
Excitation energy dependence of photoinduced processes in pentathiophene-perylene bisimide dyads with a flexible linker. | In the present paper, photoinduced processes in the dyad molecules of pentathiophene (5T) and perylene-3,4:9,10-bis(dicarboximide) (PDI) with a flexible alkyl linker (propyl or hexyl) were investigated by using femtosecond laser flash spectroscopy in various solvents. Since absorption of 5T covers the wavelength region... | 18,788,715 |
Antitumor compounds based on a natural product consensus pharmacophore. | We report the design and highly enantioselective synthesis of a potent analogue of the spliceosome inhibitor FR901464, based on a non-natural product scaffold. The design of this compound was facilitated by a pharmacophore hypothesis that assumed key interaction types that are common to FR901464 and an otherwise unrela... | 18,788,726 |
Glycol porphyrin derivatives as potent photodynamic inducers of apoptosis in tumor cells. | The design and synthesis of glycol-functionalized porphyrins that contain one to four low molecular weight glycol chains that are linked via ether bonds to the meta-phenyl positions of meso-tetraphenylporphyrin and the comparison of fluorinated and nonfluorinated para derivatives are reported. The cellular uptake and p... | 18,788,727 |
Structure-activity relationship studies for the peptide portion of the bladder epithelial cell antiproliferative factor from interstitial cystitis patients. | We performed comprehensive structure-activity relationship (SAR) studies on the peptide portion of antiproliferative factor (APF), a sialylated frizzled-8 related glycopeptide that inhibits normal bladder epithelial and urothelial carcinoma cell proliferation. Glycopeptide derivatives were synthesized by solid-phase me... | 18,788,730 |
Heteroarylnitrones as drugs for neurodegenerative diseases: synthesis, neuroprotective properties, and free radical scavenger properties. | New 1,2,4-thiadiazolylnitrones and furoxanylnitrones were developed and evaluated as neuroprotective agents on a human neuroblastoma (SH-SY5Y) cells model. They inhibited at low micromolar concentrations the oxidative damage and the death induced by exposure to hydrogen peroxide. These heteroarylnitrones showed excelle... | 18,788,732 |
A rational basis for the axial ligand effect in C-H oxidation by [MnO(porphyrin)(X)]+ (X = H2O, OH-, O2-) from a DFT study. | Oxyl radical character in the MnO group of the title system is shown from a density functional theory study to be essential for efficient C-H cleavage, which is a key step in C-H oxidation. Since oxyl species have elongated Mn-O bonds relative to the more usual oxo species of type MnO, the normal expectation would be t... | 18,788,735 |
Influence of altitudinal variation on the content of phenolic compounds in wild populations of Calluna vulgaris, Sambucus nigra, and Vaccinium myrtillus. | This study deals with the effect of altitudinal variation on the content of phenolic compounds in three traditional herbal plants, which are also consumed as food in Central Europe. Herbs of Calluna vulgaris (L.) HULL, flowers and fruits of Sambucus nigra L., and berries of Vaccinium myrtillus L. collected in the Natur... | 18,788,745 |
Sequential interval motif search: unrestricted database surveys of global MS/MS data sets for detection of putative post-translational modifications. | Tandem mass spectrometry is the prevailing approach for large-scale peptide sequencing in high-throughput proteomic profiling studies. Effective database search engines have been developed to identify peptide sequences from MS/MS fragmentation spectra. Since proteins are polymorphic and subject to post-translational mo... | 18,788,753 |
Reversible UV-light-induced ultrahydrophobic-to-ultrahydrophilic transition in an alpha-Fe2O3 nanoflakes film. | We describe a simple and robust approach to fabricating an alpha-Fe2O3 switchable surface. The hydrophobicity of alpha-Fe2O3 nanostructures was observed for the first time. A remarkable surface wettability transition can be easily achieved by ultraviolet (UV) illumination. The distinctive properties of surface defects ... | 18,788,762 |
Linkage isomerism in the binding of pentapeptide Ac-His(Ala)3His-NH2 to (ethylenediamine)palladium(II): effect of the binding mode on peptide conformation. | The reaction of the pentapeptide Ac-His1-Ala2-Ala3-Ala4-His5-NH2 (AcHAAAHNH2) (1) with [Pd(en)(ONO2)2] (en = NH2CH2CH2NH2) in either DMF-d(7) or H2O:D2O (90%:10%) gave three linkage isomers of [Pd(en)(AcHAAAHNH2)](2+) (2), 2a, 2b, and 2c, which differ only in which pair of imidazole nitrogen atoms bind to Pd. In the mo... | 18,788,796 |
Supramolecular chemistry in the structure direction of microporous materials from aromatic structure-directing agents. | A combination of fluorescence spectroscopy, thermogravimetric analysis, and molecular mechanics calculations has been used to study the structure-directing effect of the aromatic benzylpyrrolidine (BP) molecule (and its monofluorinated derivatives), and (S)-(-)-N-benzylpyrrolidine-2-methanol (BPM) in the synthesis of t... | 18,788,801 |
Fullerene-based anchoring groups for molecular electronics. | We present results on a new fullerene-based anchoring group for molecular electronics. Using lithographic mechanically controllable break junctions in vacuum we have determined the conductance and stability of single-molecule junctions of 1,4-bis(fullero[c]pyrrolidin-1-yl)benzene. The compound can be self-assembled fro... | 18,788,808 |
Guar foaming albumin: a low molecular mass protein with high foaming activity and foam stability isolated from guar meal. | The water extract of guar meal ( Cyamopsis tetragonolobus) was examined for its foamability. Compared with egg white, the extract showed an extraordinary foam stability: no drainage after 3 h of standing in contrast to 65% drainage for egg white at the same protein concentration. The acid-precipitated protein from the ... | 18,788,814 |
Interaction of Fe(III) tetrakis(4-N-methylpyridinium)porphyrin with sodium dodecyl sulfate at submicellar concentrations. | Interaction of water soluble Fe(III) tetrakis(4- N-methylpyridinium)porphyrin (Fe(III)TMPyP) with sodium dodecyl sulfate (SDS) in submicellar concentrations has been studied by surface tension, optical absorption, resonance light scattering (RLS), zeta-potential, and energy dispersive X-ray spectroscopy (EDS) measureme... | 18,788,822 |
Resolving sub-diffraction limit encounters in nanoparticle tracking using live cell plasmon coupling microscopy. | We use plasmon coupling between individual gold nanoparticle labels to monitor subdiffraction limit distances in live cell nanoparticle tracking experiments. While the resolving power of our optical microscope is limited to approximately 500 nm, we improve this by more than an order of magnitude by detecting plasmon co... | 18,788,826 |
Double-walled boron nitride nanotubes grown by floating catalyst chemical vapor deposition. | One-dimensional nanostructures exhibit quantum confinement which leads to unique electronic properties, making them attractive as the active elements for nanoscale electronic devices. Boron nitride nanotubes are of particular interest since, unlike carbon nanotubes, all chiralities are semiconducting. Here, we report a... | 18,788,828 |
Best practice in diagnostic immunohistochemistry: prostate carcinoma and its mimics in needle core biopsies. | The unrelenting challenge encountered when differentiating limited-volume prostate carcinoma and sometimes subtle variants from its many morphologic mimics has increased the use of ancillary immunohistochemistry in routine prostate needle biopsies. The availability of prostate cancer-associated and basal cell-associate... | 18,788,849 |
Dental anomalies of number in the permanent dentition of patients with bilateral cleft lip: radiographic study. | To radiographically evaluate the prevalence of dental anomalies in patients with complete and incomplete bilateral cleft lip, comparing the prevalence of anomalies between genders and cleft types. Hospital for Rehabilitation of Craniofacial Anomalies, University of São Paulo (HRAC/USP), Bauru, São Paulo, Brazil. 150 ra... | 18,788,864 |
DNA methylation changes during cleft palate formation induced by retinoic acid in mice. | The aim of this study was to analyze epigenetic (specifically, DNA methylation) participation in the mechanisms of cleft palate only induced by maternal exposure to all-trans retinoic acid in mice. Cleft palate only was induced in fetuses by maternal exposure to all-trans retinoic acid. Their secondary palates were exc... | 18,788,878 |
Architectural malformation of the muscularis propria as a cause for intestinal pseudo-obstruction: two cases and a review of the literature. | Two patients are presented with intestinal pseudo-obstruction and malformations of their intestinal muscularis propria. Histopathological findings in each case indicate a distinct alteration of intestinal muscle architecture. The 1st patient, a teenager with lifelong constipation, had an additional circular muscle tuni... | 18,788,889 |
Endogenous thyrotropin and triiodothyronine concentrations in individuals with thyroid cancer. | Thyroid hormone suppression therapy is associated with decreased recurrence rates and improved survival in patients with differentiated thyroid cancer. Recently higher baseline thyrotropin (TSH) levels have been found to be associated with a postoperative diagnosis of differentiated thyroid cancer. Our objective was to... | 18,788,918 |
Exophytic and ulcerated local recurrence of papillary thyroid carcinoma with spectacular response to external beam radiotherapy. | A 60-year-old female patient with a history of multifocal papillary thyroid carcinoma was referred to the endocrinology clinic for an exophytic and ulcerated lesion at the right base of the neck. Twelve years earlier she had undergone a total thyroidectomy for multinodular goiter. Four years after the total thyroidecto... | 18,788,923 |
Fibroblast growth factor-2 and -4 promote the proliferation of bone marrow mesenchymal stem cells by the activation of the PI3K-Akt and ERK1/2 signaling pathways. | Bone marrow mesenchymal stem cells (BMMSCs) have the capacity for self-renewal, and differentiation into a variety of cell types. They thus represent an attractive source of material for cell therapy. However, little is known about the mechanisms underlying the proliferation of BMMSCs. The purpose of this study was to ... | 18,788,932 |
Differences in clinical disease and immune response of pigs challenged with a high-dose versus low-dose inoculum of porcine reproductive and respiratory syndrome virus. | Porcine reproductive and respiratory syndrome virus (PRRSV) continues to be an economically important infectious disease of swine. Mechanisms governing activation of the innate immune response to PRRSV remain to be elucidated. Virulence differences observed between PRRSV isolates have been attributed to replication abi... | 18,788,940 |
Differential regulation of GM1 and asialo-GM1 expression by T cells and natural killer (NK) cells in respiratory syncytial virus infection. | We previously reported that respiratory syncytial virus (RSV) infection increases lung CD8(+) T cell GM1 expression. The related lipid asialo-GM1 (ASGM1) is expressed by T cells in viral infection and by natural killer (NK) cells. The in vivo co-expression of GM1 and ASGM1 by immune cells is not defined. Here we analyz... | 18,788,941 |
Alcoholism screening in patients with advanced cancer: impact on symptom burden and opioid use. | Alcoholism is a devastating disease that can cause patient and family suffering and is frequently underdiagnosed. Preliminary studies suggest that it is associated with increased symptom expression and opioid dose escalation. The CAGE questionnaire is a widely used tool for alcoholism screening. The purpose of this stu... | 18,788,955 |
Staff experiences with end-of-life care in the pediatric intensive care unit. | The purposes of this study were to describe the experiences of pediatric intensive care unit (PICU) staff caring for a child who dies, and to determine whether responses included unprompted indications of moral distress as described in the literature. This qualitative, descriptive study consisted of semistructured inte... | 18,788,959 |
Palliative care telephone consultation: who calls and what do they need to know? | Access to expertise in palliative management in areas not served by palliative care consultants is an ongoing challenge. This study examines a unique service offered in British Columbia: a 24-hour telephone hotline available to physicians, nurses, and pharmacists across the province. Records of calls to the hotline ove... | 18,788,963 |
Risk of alcohol-exposed pregnancies among low-income, illicit drug-using women. | Poor women of childbearing age who use crack, cocaine, marijuana, and heroin may be at risk for having an alcohol-exposed pregnancy because of concurrent alcohol use. Women who use illicit drugs may not know the harmful effects of fetal alcohol exposure. Fetal alcohol exposure is a leading cause of developmental disabi... | 18,788,989 |
[First results of open randomized clinical study of Acridilol in combination therapy of patients with arterial hypertension and obesity or type 2 diabetes (Mellitus-Open Multicenter Clinical Study ACCORD)]. | To study efficacy and safety of a preparation of carvedilol Acridilol (Akrikhin, Russia) in patients with mild and moderate arterial hypertension (AH) and obesity and/or compensated type 2 diabetes mellitus (DM). Patients (n=592) suffering from mild to moderate AH in combination with DM and/or obesity participated in a... | 18,789,007 |
[Molecular mechanisms of effects of rosuvastatin on systemic oxidative stress and endogenous inflammation in patients with atherosclerosis]. | Aim of the study was to investigate peculiarities of effects of rosuvastatin on the state of oxidative stress and endogenous inflammation in patients with extensive atherosclerosis. Patients with extensive atherosclerosis included into the study (n=46, mean age 56.5 +/- 2.2 years) were distributed to 2 equivalent accor... | 18,789,009 |
[The influence of purine nucleotides and adenosine on bioelectrical activity of bat (Pipistrellus nathusii) heart]. | The aim of work was to investigate effects of adenosine, AMP, GMP and ADP-ribose on bioelectric activity of bat heart. Purine nucleotides decreased action potential duration at level of 90% (APD90) repolarization in bat ventricular myocardium. When preparation of right ventricle was paced with frequency of 6 Hz, APD50 ... | 18,789,010 |
[Prognostication of results of coronary artery bypass surgery in men living in the North]. | We analyzed immediate and remote results of coronary artery bypass surgery and prognostication of outcome of the intervention in dependence on various risk factors in 576 men aged 29 - 71 years living in the North. We formed a model with strong prognostic effect on lethal outcome during in-hospital postoperative period... | 18,789,024 |
The importance of clinical experience for mental health nursing - part 2: relationships between undergraduate nursing students' attitudes, preparedness, and satisfaction. | Clinical experience is consistently emphasized in research findings as the primary influence in encouraging more positive attitudes to mental health nursing. The available research, however, presents two major limitations. First, it does not measure the specific factors that might contribute to a positive clinical expe... | 18,789,043 |
Hydrolysis of arbutin to hydroquinone by human skin bacteria and its effect on antioxidant activity. | Arbutin, the beta-D-glucopyranoside of hydroquinone, is a skin whitening cosmetic ingredient. Compared with arbutin, hydroquinone is a more potent skin lightening agent, but shows cytotoxicity, nephrotoxicity, and genotoxicity. To evaluate whether skin microflora can hydrolyze arbutin to hydroquinone, we measured the h... | 18,789,053 |
Effects of various concentrations of glycolic acid at the corneoxenometry and collaxenometry bioassays. | Glycolic acid is an alpha-hydroxy acid used as a chemical peeling for more than a quarter century. The primary tissue target is the stratum corneum. This study aims to assess the effects of various concentrations of glycolic acid on the stratum corneum and collagen fibers using two selected bioassays. Corneoxenometry w... | 18,789,054 |
Effect of Cuscuta reflexa Roxb on androgen-induced alopecia. | Alopecia is a psychologically distressing condition. Androgenetic alopecia, which affects millions of men and women, is an androgen-driven disorder. Here, Cuscuta reflexa Roxb is evaluated for hair growth activity in androgen-induced alopecia. Petroleum ether extract of C. reflexa was studied for its hair growth-promot... | 18,789,055 |
The effect of topical caffeine on the morphology of swine hypodermis as measured by ultrasound. | Cellulite or lipodystrophy involves the modification of the subcutaneous adipose tissue. A wide variety of topical products is available to combat cellulite, but these have difficulties in being absorbed through the skin. One option is the therapeutic use of the ultrasound to enhance the trans-dermic transport of these... | 18,789,063 |
Neonatal pemphigus vulgaris. | A male newborn with skin erosions was born to a 32-year-old woman who was under treatment for pemphigus vulgaris that had been diagnosed 16 months earlier. Antibodies to desmoglein (Dsg)1 and Dsg3 were analyzed by enzyme-linked immunosorbent assay. Index values of antibodies to Dsg1 and Dsg3 were 49 (normal index value... | 18,789,074 |
Pilomatricomas in Turner syndrome. | Pilomatricomas are benign, cutaneous tumors of the hair matrix cells, which present predominantly in childhood. Although usually an isolated finding, they have been described in association with several inherited conditions. We report a 10-year-old girl with Turner syndrome who has two pilomatricomas, including one gia... | 18,789,085 |
Intrapulmonary administration of recombinant activated factor VII in diffuse alveolar haemorrhage: a report of two case stories. | Diffuse alveolar haemorrhage (DAH) is a serious pulmonary complication characterised by a high mortality rate and the absence of specific treatment. The intrapulmonary administration of activated recombinant factor VII (rFVIIa) in DAH was recently published in six patients by Heslet et al with an efficient hemostatic e... | 18,789,132 |
Fibrolipoma of the lip treated by diode laser surgery: a case report. | Several neoplasms of the adipose tissue can involve the soft tissues of the head and neck region. These neoplasms are mainly treated surgically and an accurate histological examination is mandatory for a precise diagnosis. We report a case of fibrolipoma involving the lower lip of a 43-year-old man, which was successfu... | 18,789,134 |
Magnet therapy for the relief of pain and inflammation in rheumatoid arthritis (CAMBRA): a randomised placebo-controlled crossover trial. | Rheumatoid arthritis is a common inflammatory autoimmune disease. Although disease activity may be managed effectively with prescription drugs, unproven treatments such as magnet therapy are sometimes used as an adjunct for pain control. Therapeutic devices incorporating permanent magnets are widely available and easy ... | 18,789,135 |
Role of hypoxia-inducible factor 1 alpha in the integrity of articular cartilage in murine knee joints. | Chondrocytes have to withstand considerable hypoxic conditions within the avascular articular cartilage. The present study investigated the effects of inhibiting or stabilizing hypoxia-inducible factor (HIF)-1 alpha by 2-methoxyestradiol or dimethyloxaloylglycine on the progression of osteoarthritis in murine knee join... | 18,789,153 |
Programmed inappropriate ICD ventricular defibrillation for cardioversion of persistent atrial fibrillation. | In this report we briefly describe a patient with a dual chamber implantable cardioverter defibrillator in the context of severe ischemic cardiomyopathy who developed persistent atrial fibrillation. After appropriate anticoagulation and under mild sedation the patient was successfully cardioverted to sinus rhythm afte... | 18,789,158 |
Predictors of nutritional status among community-dwelling older adults in Wuhan, China. | To examine the nutritional and functional status of community older adults in China, to identify the related factors and best predictors of elder nutrition. A cross-sectional, descriptive correlation design was utilized. A convenience sample of 162 community older adults (aged > or = 65 years) were administered thre... | 18,789,169 |
Priming a perspective in Spanish monolingual children: the use of syntactic alternatives. | We used a syntactic priming paradigm to show priming effects for active and passive forms in monolingual Spanish-speaking four- and five-year-olds. In a baseline experiment, we examined children's use of the fue-passive form and found it was virtually non-existent in their speech, although they produced important eleme... | 18,789,181 |
A preliminary study of negative appraisals and dysfunctional coping associated with post-traumatic stress disorder symptoms following myocardial infarction. | To investigate associations between post-traumatic stress disorder (PTSD) symptoms following myocardial infarction (MI) and subjective experience of MI, negative perception of consequences, negative appraisals of symptoms, and use of dysfunctional coping strategies, as described by Ehlers and Clark's (2000) model of PT... | 18,789,186 |
Effects of psychological state on pain perception in the dental environment. | Psychological factors have an important influence on pain perception. Both in the clinic and in experimental settings, distraction has been shown to reduce pain. Further, negative emotions increase pain, whereas positive emotions have the opposite effect. Other more complex psychological states alter the way we feel pa... | 18,789,200 |
[Histone deacetylases: a new class of efficient anti-tumor drugs]. | Circa twenty-five years ago, cancer research was dominated by the concept that the origin of cancer was genetic. Thousands of genetic alterations have indeed been identified involving more than hundred different genes in cancer development. Today, the model has evolved: it has been demonstrated that malignancies can be... | 18,789,222 |
Treatment with LXR agonists after focal cerebral ischemia prevents brain damage. | Stroke is characterized by massive inflammation in areas surrounding the injury that magnifies damage to the brain. The liver X receptors (LXRs) are nuclear receptors that regulate cholesterol, lipid, and glucose metabolism. Synthetic LXR agonists have potent anti-inflammatory properties in a variety of settings, inclu... | 18,789,330 |
A generalized compartmental model to estimate the fibre mass in the ruminoreticulum: 1. Estimating parameters of digestion. | Parameters related to the microbial digestion of nutrients in the ruminoreticulum have been estimated by fitting mathematical models to degradation profiles generated from kinetic studies. In the present paper, we propose a generalized compartmental model of digestion (GCMD) based on implicit theoretical concepts and t... | 18,789,339 |
Chlordecone, a mixed pregnane X receptor (PXR) and estrogen receptor alpha (ERalpha) agonist, alters cholesterol homeostasis and lipoprotein metabolism in C57BL/6 mice. | Chlordecone (CD) is one of many banned organochlorine (OC) insecticides that are widespread persistent organic pollutants. OC insecticides alter lipid homeostasis in rodents at doses that are not neurotoxic or carcinogenic. Pretreatment of mice or rats with CD altered tissue distribution of a subsequent dose of [(14)C]... | 18,789,348 |
Involvement of cytoskeleton in Junín virus entry. | The early events in Junín virus (JUNV) infection are not thoroughly understood. We have previously shown that JUNV enter cells by clathrin-mediated endocytosis. In this report we examine the role of microfilaments and microtubules during early virus infection. Inhibitory effects of drugs affecting main cytoskeletal com... | 18,789,362 |
Construction and evaluation of live attenuated myxoma virus vaccines with targeted virulence gene deletions. | Three deletion mutant viruses were constructed as potential vaccines against myxomatosis using the naturally attenuated Uriarra strain of myxoma virus. The viruses had the M007 (encodes a secreted gamma-interferon receptor homologue), M010 (encodes an epidermal growth factor homologue) and M011 (encodes an inhibitor of... | 18,789,367 |
Lipid peroxidation products do not activate hepatic stellate cells. | Lipid peroxidation (LPO) is known to be associated with liver fibrosis in chronic liver injury. However, direct effects of the products of LPO on liver fibrogenesis are still not clear. In this study, we examined the LPO products, such as malondiladehyde (MDA), 8-iso-prostaglandin F(2alpha) (8-iso-PGF(2alpha)), and 15-... | 18,789,371 |
Effect of the organophosphorus pesticide diazinon on glucose tolerance in type 2 diabetic rats. | We have reported that the toxicity of the organophosphorus pesticide diazinon (DZN) and its metabolites is increased in streptozotocin-induced diabetic rats (type 1 diabetic rats). In the present study, we have investigated the effect of DZN on glucose tolerance in genetic type 2 diabetic rats, Goto-Kakizaki (GK) rats.... | 18,789,379 |
The effect of lead on intracellular Ca(2+) in mouse lymphocytes. | Lead exposure is one of major public health problems. The aim of this study was to examine in vitro the effect of lead on lymphocyte intracellular Ca(2+) ([Ca(2+)]i). Lymphocytes were separated from mice spleen and treated with three doses of PbCl(2) (1, 10 and 100 micromol/L). [Ca(2+)]i was measured in a Thermo Labsys... | 18,789,383 |
Novel expression of importin alpha homologue in marine teleost, Pagrus major. | Importin alpha proteins are critical modulators of the classical nuclear protein import pathway. Although the physiological roles of importin alpha have been extensively studied in invertebrates and mammals, very little is known about their counterparts in lower vertebrates. In this study, to elucidate the roles of imp... | 18,789,395 |
The extent of lower extremity occlusive disease predicts short- and long-term patency following endovascular infrainguinal arterial intervention. | Endovascular revascularization of the femoral-politeal arterial segment has gained acceptance despite lower patency than surgical bypass due to lower morbidity. Choosing patients that are ideal candidates for endovascular therapy remains controversial. We have assessed hemodynamic factors that might predict longer prim... | 18,789,419 |
Musculoskeletal complaints among nurses related to patient handling tasks and psychosocial factors--based on logbook registrations. | The aims were to evaluate the inter-method reliability of a registration sheet for patient handling tasks, to study the day-to-day variation of musculoskeletal complaints (MSC) and to examine whether patient handling tasks and psychosocial factors were associated with MSC. Nurses (n=148) fulfilled logbooks for three co... | 18,789,431 |
Reductive openings of benzylidene acetals. Kinetic studies of borane and alane activation by Lewis acids. | The reaction kinetics for a number of reductive openings of methyl 2,3-di-O-benzyl-4,6-O-benzylidene-alpha-D-glucopyranoside have been investigated. Openings to give free HO-6 (using BH(3) x THF-AlCl(3)-THF or LiAlH(4)-AlCl(3)-Et(2)O) follow first order kinetics, while reactions yielding free HO-4 (using BH(3) x NMe(3)... | 18,789,434 |
The stiffness characteristics of hybrid Ilizarov fixators. | The use of hybrid Ilizarov models around femoral area is gaining clinical popularity lately. Hybrid systems show different mechanical properties. The purpose of this report is to examine the stiffness characteristics of the C-arch and half-pins on the hybrid Ilizarov fixators. Eight models that included standard Ilizar... | 18,789,446 |
Determination of organochlorine pesticides in sediment using graphitized carbon black solid-phase extraction and gas chromatography/mass spectrometry. | An analytical method for the determination of organochlorine pesticides (OCPs) in sediment samples involves ultrasonic extraction, solid-phase extraction (SPE), gas-chromatography (GC)/electron-capture detection (ECD), and GC/mass spectrometry (MS). OCPs were extracted from sediment samples by ultrasonication in mixtur... | 18,789,449 |
Drug resistance profile of Mycobacterium tuberculosis isolates from pulmonary tuberculosis patients in Jos, Nigeria. | The drug resistance profile of 100 Mycobacterium tuberculosis isolates from pulmonary tuberculosis (PTB) cases in Jos, Nigeria, was investigated between August 2006 and September 2007. Drug susceptibility testing for 50 new, 11 follow-up and 39 unclassified cases of PTB was performed on Löwenstein-Jensen medium by the ... | 18,789,463 |
Microsurgical removal of sylvian fissure lipoma with pterion keyhole approach-case report and review of the literature. | Intracranial lipomas are thought to be congenital in origin and are very rare, representing 0.1% to 1.7% of all intracranial tumors. Most ICLs are located at midline. Lipomas at sylvian fissure are extremely rare. They are slow growing, and biological course is favorable even without surgical treatment. A Medline searc... | 18,789,493 |
Endonasal transsphenoidal endoscopy-assisted removal of a shotgun pellet in the sphenoid sinus: a case report. | Gunshot accidents are not uncommon in Taiwan, but involvement limited to the ocular region and sphenoid sinus is rare. Minimal invasive treatment by endonasal transsphenoidal endoscopy-assisted procedure should be considered if there are no additional injuries in the craniocerebral region. A 39-year-old man had severe ... | 18,789,498 |
Retroperitoneal lymph node dissection (RPLND). | Pelvic and paraaortic lymph nodes are common sites of metastases from gynecologic malignancies and may act as a sanctuary of chemoresistant tumor cells in some patients. There is no doubt that the evaluation of the regional lymph nodes provides important prognostic information for patients with gynecologic malignancies... | 18,789,513 |
Tyrosine kinase-independent inhibition by genistein on spermatogenic T-type calcium channels attenuates mouse sperm motility and acrosome reaction. | Although the protein tyrosine kinase (PTK) inhibitor, genistein, has been widely used to investigate the possible involvement of PTK during reproductive functions, it is unknown whether it modulates sperm calcium channel activity. In the present study, we recorded T-type calcium currents (I(Ca,T)) in mouse spermatogeni... | 18,789,523 |
Associations between depression subtypes and substance use disorders. | Evaluating whether certain subtypes of Major Depressive Disorder (MDD) are more strongly associated with Substance Use Disorders (SUDs) may help clarify reasons for MDD-SUD relations. Therefore, this study compared DSM-IV-defined non-atypical/non-melancholic depression (undifferentiated depression; n=365), atypical dep... | 18,789,540 |
Are relational style and neuropsychological performance predictors of social attributions in chronic schizophrenia? | Attributional style is defined as the pervasive tendency to explain the cause of social actions in terms of oneself, or others, or the context of the event. While the clinical correlates of this aspect of social cognition have been widely researched, its links with relationship style and neuropsychological performance,... | 18,789,541 |
Good grief: staff responses to childbearing loss. | The emotional implications for staff of loss in childbearing have been inadequately addressed. In this paper I focus on maternity situations, but it is necessary to draw on other areas' findings. I address crying by the care provider and its association with staff grief. The conclusion emerges that education is likely ... | 18,789,560 |
Adenovirus-mediated ING4 expression suppresses lung carcinoma cell growth via induction of cell cycle alteration and apoptosis and inhibition of tumor invasion and angiogenesis. | Previous studies demonstrated that ING4 as a novel member of ING (inhibitor of growth) family has potential effect on tumor inhibition via multiple pathways. However, adenovirus-mediated ING4 expression in inhibition of human tumors has not been reported. To explore its therapeutic effect on human lung carcinoma, we co... | 18,789,575 |
Perchlorate adsorption and desorption on activated carbon and anion exchange resin. | The mechanisms of perchlorate adsorption on activated carbon (AC) and anion exchange resin (SR-7 resin) were investigated using Raman, FTIR, and zeta potential analyses. Batch adsorption and desorption results demonstrated that the adsorption of perchlorate by AC and SR-7 resin was reversible. The reversibility of perc... | 18,789,577 |
Pharmacokinectics of vancomycin and amikacin in the subeschar tissue fluid in patients with severe burn. | The specific aim of this study was to investigate the pharmacokinetic parameters of antibiotics represented by vancomycin and amikacin in the subeschar tissue fluid (STF) in patients with early stage severe burn. Twenty patients were studied: age 30.7+/-8.0 years old, weight 60.6+/-8.4 kg, total burn surface area (TBSA... | 18,789,586 |
The comparative study of solvents to expedite removal of bitumen. | Hot-bitumen burn is a unique case in all types of burns. This melting substance is difficult to remove when it adheres to the skin and solidifies. It causes burns and sticks to the skin when it is cooled to the skin temperature. Some reports are available on many kinds of solvents for the removal of solid bitumen. Howe... | 18,789,588 |
The extent of thermal injury affects fractions of mononuclear cells. | The mononuclear cell (MNC) fraction contains a variety of cell types, including stem cells such as endothelial progenitor cells (EPCs). EPC can rapidly revascularise ischaemic areas, but their role in burns is unclear. This study investigates how thermal injury to the skin might influence mononuclear cells, CD34(+) cel... | 18,789,594 |
Genistein and phycocyanobilin may prevent hepatic fibrosis by suppressing proliferation and activation of hepatic stellate cells. | Hepatic fibrosis reflects hepatotoxin-mediated activation of hepatic stellate cells, resulting in their proliferation and transformation to myofibroblasts that secrete collagen. This activation is suppressed by estrogen, an effect which explains the decreased risk for hepatic fibrosis enjoyed by premenopausal women and... | 18,789,597 |
Sex and race differences in the relative lengths of metacarpals and metatarsals in human skeletons. | Previous research has revealed that the ratios of the lengths of various pairs of human fingers differ in males and females. In an attempt to determine whether parallel sex differences also exist in the relative lengths of human metacarpals and metatarsals, the lengths of the metapodials for both hands and both feet we... | 18,789,613 |
Actin depolymerization contributes to ethanol inhibition of NMDA receptors in primary cultured cerebellar granule cells. | We have previously reported that a 30s ethanol (10 and 100mM) pre-exposure significantly enhanced EtOH inhibition of N-methyl-d-aspartate (NMDA-induced currents)-induced peak currents in primary cultured cerebellar granule cells (CGCs). The purpose of this study was to determine if intracellular factors play a role in ... | 18,789,629 |
Sinus membrane elevation in combination with placement of blasted implants: a 3-year case report of sinus augmentation without grafting material. | Owing to the increasing use of dental implants to restore edentulous conditions, clinicians often face situations where available bone volumes are reduced and need to be augmented before implant placement. This is common in the posterior maxilla, where the presence of the maxillary sinus combined with severe atrophy of... | 18,789,651 |
The social and recreational characteristics of adults with intellectual disability and pica living in institutions. | This paper reports on the social life of adults with intellectual disability (ID) who engage in pica behaviour (i.e., ingestion of non-food items). Secondary analyses were conducted on the population of adults residing in Ontario's three remaining specialized institutions for persons with ID (N=1008); 220 individuals (... | 18,789,647 |
Effects of food fortification on nutritional and functional status in frail elderly nursing home residents at risk of malnutrition. | Malnutrition is a frequent problem in the elderly and is associated with an impaired functional status and higher morbidity and mortality. In this study we evaluated the effect of a 12-wk nutritional intervention with fortified food on nutritional and functional status in nursing home residents at risk of malnutrition.... | 18,789,649 |
Temporal similarity measures for querying clinical workflows. | In this paper, we extend a preliminary proposal and discuss in a deeper and more formal way an approach to evaluate temporal similarity between clinical workflow cases (i.e., executions of clinical processes). More precisely, we focus on (i) the representation of clinical processes by using a temporal conceptual workfl... | 18,789,660 |
Lysosomal and proteasome-dependent proteolysis are differentially regulated by insulin and/or amino acids following feeding in young, mature and old rats. | Skeletal muscle proteolysis is inhibited by oral feeding in the young and mature but not in the elderly. However, the proteolytic pathway(s) responsible for the decreased muscle proteolysis in the postprandial (PP) state is (are) unknown in the young. Moreover, muscle proteolysis is inhibited by both insulin (INS) and ... | 18,789,664 |
Dihydroxy-cholecalciferol stimulates adipocytic differentiation of porcine mesenchymal stem cells. | Dihydroxy-cholecalciferol [1,25(OH)2D3] has been shown to have pleiotropic effects on the differentiation of mesenchymal stem cells (MSC) based on species and culture conditions. We have examined the effects of 1,25(OH)2D3 on the differentiation of porcine MSC under culture conditions designed to promote proliferation ... | 18,789,667 |
Design, synthesis and characterization of podocarpate derivatives as openers of BK channels. | We found that the podocarpic acid structure provides a new scaffold for chemical modulators of large-conductance calcium-activated K(+) channels (BK channels). Structure-activity analysis indicates the importance of both the arrangement (i.e., location and orientation) of the carboxylic acid functionality of ring A and... | 18,789,683 |
Artificial neural network model for earthquake prediction with radon monitoring. | Apart from the linear monitoring studies concerning the relationship between radon and earthquake, an artificial neural networks (ANNs) model approach is presented starting out from non-linear changes of the eight different parameters during the earthquake occurrence. A three-layer Levenberg-Marquardt feedforward learn... | 18,789,709 |
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