title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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FcgammaRIIB signals inhibit BLyS signaling and BCR-mediated BLyS receptor up-regulation. | These studies investigate how interactions between the BCR and FcgammaRIIB affect B lymphocyte stimulator (BLyS) recep-tor expression and signaling. Previous studies showed that BCR ligation up-regulates BLyS binding capacity in mature B cells, reflecting increased BLyS receptor levels. Here we show that FcgammaRIIB co... | 18,791,164 |
Regulated expression of caspase-12 gene in human retinal pigment epithelial cells suggests its immunomodulating role. | To investigate the expression and regulation of the short form of caspase-12, caspase-12S, in human retinal pigment epithelial (hRPE) cells. hRPE cells were stimulated by the proinflammatory agents IL-1beta (2 ng/mL) and TNF-alpha (20 ng/mL); LPS (1000 ng/mL); coculture with monocytes; the immunomodulating agent cyclos... | 18,791,174 |
Coping with chronic pain among younger, middle-aged, and older adults living with neurological injury and disease. | Objective. This article compares use of pain coping strategies among older, middle-aged, and younger adults living with chronic pain and seeks to determine whether the relationship between pain severity and coping is moderated by age. Method. Participants were 464 adults reporting chronic pain secondary to multiple scl... | 18,791,184 |
A method for generating natural and user-defined sniffing patterns in anesthetized or reduced preparations. | Sniffing has long been thought to play a critical role in shaping neural responses to odorants at multiple levels of the nervous system. However, it has been difficult to systematically examine how particular parameters of sniffing behavior shape odorant-evoked activity, in large part because of the complexity of sniff... | 18,791,186 |
Expression of Xhdsi-1VOC, a novel member of the vicinal oxygen chelate (VOC) metalloenzyme superfamily, is up-regulated in leaves and roots during desiccation in the resurrection plant Xerophyta humilis (Bak) Dur and Schinz. | The annotation of novel plant genes is frequently based on sequence and structural similarity to known protein motifs. Understanding the biological function of these genes is dependent on identifying conditions under which they are activated, however. The resurrection plant, Xerophyta humilis is a good model system for... | 18,791,196 |
Insulator and Ovo proteins determine the frequency and specificity of insertion of the gypsy retrotransposon in Drosophila melanogaster. | The gypsy retrovirus of Drosophila is quite unique among retroviruses in that it shows a strong preference for integration into specific sites in the genome. In particular, gypsy integrates with a frequency of > 10% into the regulatory region of the ovo gene. We have used in vivo transgenic assays to dissect the rol... | 18,791,225 |
Dominance, overdominance and epistasis condition the heterosis in two heterotic rice hybrids. | Two recombinant inbred (RI) populations having 194 and 222 lines each, derived, respectively, from a highly heterotic inter- (IJ) and intrasubspecific (II) hybrid, were backcrossed to their respective parents. The RI and two backcross populations along with F1 and its two parents of each hybrid were evaluated for nine ... | 18,791,236 |
A novel septin-associated protein, Syp1p, is required for normal cell cycle-dependent septin cytoskeleton dynamics in yeast. | Septins are a family of GTP-binding proteins whose heterooligomeric complex is the basic structural element of the septin filaments found in many eukaryotic organisms. In budding yeast, septins are mainly confined at the mother-daughter junction and are required for cell morphogenesis and division. Septins undergo asse... | 18,791,237 |
Selective transcriptional profiling and data analysis strategies for expression quantitative trait loci mapping in outbred F2 populations. | Genetic analysis of transcriptional profiling experiments is emerging as a promising approach for unraveling genes and pathways that underlie variation of complex biological traits. However, these genetical genomics approaches are currently limited by the high cost of microarrays. We studied five different strategies t... | 18,791,244 |
Identification of single-nucleotide polymorphism in the progesterone receptor gene and its association with reproductive traits in rabbits. | A total of 598 F2 does from a cross between the high and low lines selected divergently for uterine capacity during 10 generations were used in a candidate gene analysis. The presence of major genes affecting the number of implanted embryos and uterine capacity has been suggested in lines divergently selected for uteri... | 18,791,246 |
Suppression of pleiotropic effects of functional cryptochrome genes by Terminal Flower 1. | TERMINAL FLOWER 1 (TFL1) encodes a protein with similarity to animal phosphatidylethanolamine-binding proteins and is required for normal trafficking to the protein storage vacuole. In Arabidopsis thaliana the tfl1 mutation produces severe developmental abnormalities. Here we show that most aspects of the tfl1 phenotyp... | 18,791,256 |
In vitro hemorheological study on the hematocrit effect of human blood flow in a microtube. | In vitro experiments to investigate the hematocrit effect on human blood flow in microcirculation were carried out using a micro-PIV technique. The micro-PIV system consisted of a 2 head Nd:YAG laser as a illumination light, a cooled CCD camera, a delay generator and a personal computer for control and data processing.... | 18,791,264 |
Comparison of the adjuvanticity of aluminum salts and their combination in hepatitis B recombinant protein vaccine in assessed mice. | Several adjuvants have been evaluated for vaccine formulations but aluminum salts will continue to be used for many years due to their safety, low cost and adjuvanticity with different antigens. Two commonly used aluminum adjuvants, aluminum hydroxide and aluminum phosphate have different adjuvanticity properties. Comm... | 18,791,283 |
Hamstring injuries in sprinting - the role of eccentric exercise. | This paper assesses a specific connective tissue insufficiency induced hamstring injury occurring in the late swing/early stance phase of sprinting and jumping activities. A literature review related to hamstring injury demonstrates that eccentric muscle action is capable of producing very high forces within the series... | 18,791,318 |
Nutrition knowledge of sports physical therapists. | This descriptive study determined the nutrition knowledge of sports physical therapists. A Nutrition Knowledge Test was designed and mailed to 1000 members of the Sports Section of the American Physical Therapy Association. The 498 therapists who returned completed questionnaires achieved an overall mean knowledge scor... | 18,791,320 |
Biochemical markers in glucocorticoid-induced osteoporosis. | Following the introduction of corticosteroids as therapeutic agents in the 1950s, their use has been expanded so that today glucocorticoids are widely used. There are few studies in the literature directly aimed at describing the changes of bone markers following glucocorticoid administration. The interpretation of som... | 18,791,348 |
Regional recurrence after negative sentinel lymph node biopsy for melanoma. | Sentinel lymph node (SLN) biopsy has shown great utility in the management of melanoma. An analysis of regional recurrence in previously mapped negative SLN basins as the first site of relapse is performed. A retrospective query of a prospective melanoma database from 1994 to 2006 identified 1287 patients who underwent... | 18,791,358 |
The effect of age on short-term outcomes after pancreatic resection: a population-based study. | To use a large population-based cohort to determine age-dependent short-term outcomes after pancreatic resection. We identified all pancreatic resections in Texas from 1999 to 2005. Patients were stratified into 4 age groups (<60, 60-69, 70-79, and 80+ years). Bivariate and multivariate analyses were performed to de... | 18,791,366 |
Experience with more than 500 minimally invasive hepatic procedures. | To evaluate our experience with more than 500 minimally invasive hepatic procedures. Recent data have confirmed the safety and efficacy of minimally invasive liver surgery. Despite these reports, no programmatic approach to minimally invasive liver surgery has been proposed. We retrospectively reviewed all patients who... | 18,791,368 |
A third study on predicting NCLEX success with the HESI exit exam. | This was the third annual validity study designed to assess the accuracy of the HESI Exit Exam (E) in predicting NCLEX success for graduating registered and practical nursing students. As in year I (N = 2,725) and year II (N = 3,752), in year III (N = 6,277), the E was highly predictive of NCLEX success for associate d... | 18,791,386 |
Predicting NCLEX success with the HESI Exit Exam: fourth annual validity study. | The fourth annual validity study of the Health Education Systems, Inc. (HESI) Exit Exam was designed to examine not only the accuracy of the examination in predicting NCLEX success but also the degree of risk for failure of the licensure examination associated with specific scoring intervals. A descriptive comparative ... | 18,791,387 |
Designing and delivering effective online nursing courses with the evolve electronic classroom. | This case study describes how the Evolve electronic course management system was used to deliver an online Trends and Issues in Nursing course for 53 nurses-in-training at Our Lady of Lourdes School of Nursing. Evolve provided an open-ended, electronic course shell that supported the instructor's efforts to create an o... | 18,791,392 |
Critical pathway for the management of acute heart failure at the Veterans Affairs San Diego Healthcare System: transforming performance measures into cardiac care. | Acute decompensated heart failure (ADHF) is a major public health problem and leading cause for hospitalization in people 65 years and older. Admission rates for ADHF, accounted for more than 1 million heart failure (HF) hospitalizations in 2004, and more than 6.5 million inpatient hospital days. Despite significant ad... | 18,791,404 |
Nursing program assessment and evaluation: evidence-based decision making improves outcomes. | The authors explore how an evidence-based decision-making process improved National Council Licensure Examination passing rates for a bachelor of science in nursing program. The process is one that may be applicable to other nursing programs despite differences in school mission, philosophy, and student population. The... | 18,791,402 |
Diffusion tensor imaging of the kidney with parallel imaging: initial clinical experience. | To evaluate the clinical feasibility of diffusion tensor imaging (DTI) of the kidney in volunteers and patients with renal diseases. Ten volunteers and 22 patients (mean age, 56 +/- 14.3) with renal masses and renal artery stenosis underwent breath-hold coronal fat-saturated echo-planar DTI (as provided by the manufact... | 18,791,409 |
Evaluation of ovarian tumors by proton magnetic resonance spectroscopy at three Tesla. | The purpose of this study was to determine the feasibility of acquiring in vivo proton magnetic resonance spectroscopy of ovarian lesions at a magnetic field strength of 3 Tesla (T). The goal was to provide potentially diagnostic biochemical information that may aid in the characterization of ovarian neoplasms detected... | 18,791,417 |
Left lateral segmentectomy for pediatric live-donor liver transplantation: special attention to segment IV complications. | During left lateral segmentectomy for live-donor liver transplant, the vascular inflow to segment IV can be compromised. An area of ischemia can be seen intraoperatively and further segment IV resection may be needed to prevent necrosis and abscess formation. From July 1995 to February 2007, 324 consecutive living dono... | 18,791,451 |
Atorvastatin down-regulates the primate cellular response to porcine aortic endothelial cells in vitro. | Using mixed lymphocyte reaction (MLR), the effect of atorvastatin on proliferation of human and baboon peripheral blood mononuclear cells (PBMCs) and human CD4+ T cells in response to wild-type (WT) and alpha-1,3-galactosyltransferase gene-knockout (GTKO) porcine aortic endothelial cells (pAECs) was investigated. swine... | 18,791,456 |
Evaluation of thalamocortical impulse propagation in the akinetic Rigd type of Parkinson's disease using high-frequency (600 Hz) SEP oscillations. | Human median nerve somatosensory evoked potentials exhibit low-amplitude, high-frequency (600 Hz) oscillations (HFOs) superimposed onto the primary cortical response 'N20.' Previous EEG-studies indicated the HFOs to reflect in part activity generated at the thalamus and within the thalamocortical radiation. Expecting i... | 18,791,468 |
Pneumococcal purpura fulminans successfully treated with activated protein C. | Evidence suggests that sepsis is a systemic inflammatory condition complicated by dysequilibrium in coagulation and fibrinolytic homeostasis, with a shift in the balance towards increased coagulation over fibrinolysis. Protein C is a natural anticoagulant consumed and inactivated during sepsis. We present the case of a... | 18,791,506 |
Anemia following Roux-en-Y surgery for morbid obesity: a review. | Morbid obesity is a significant problem in the Western world. Recently, there has been an increase in the number of patients undergoing surgical weight loss procedures. Currently, the most widely performed procedure is the Roux-en-Y gastric bypass operation which combines restriction of food intake with malabsorption o... | 18,791,538 |
Determinants of cataract surgical opportunities and complication rates in UK higher specialist training. | The volume of cataract surgery performed by trainee ophthalmologists in the UK, and the complication rates experienced by those trainees is unknown. As a result, no appropriate audit benchmark exists for trainees or their trainers. This study describes the surgical opportunities and rates of posterior capsule rupture (... | 18,791,546 |
Retinal microstructure in patients with EFEMP1 retinal dystrophy evaluated by Fourier domain OCT. | To investigate retinal microstructure of patients affected with malattia leventinese (MLVT) and mutation in the EFEMP1 gene using high-resolution optical coherence tomography (OCT). Patients diagnosed with MLVT received a comprehensive eye exam, full-field and multifocal electroretinogram testing and imaging with a hig... | 18,791,549 |
Pain perception during inferior alveolar injection administered with the Wand or conventional syringe. | This study compared a computerised device (the Wand) with a conventional syringe in terms of the pain of needle insertion and injection during inferior alveolar nerve (IAN) block injection. The subjects were 40 patients between the ages of 18 and 30 years requiring local anaesthesia for dental restoration in the mandib... | 18,791,585 |
Unusual complications of the subcutaneous port catheter. | Several complications following both implantation and long-term usage of port catheters have been documented in many reports. With this article, we want to report two rare complications of the port-a-cath. Retrospective chart analysis was performed on 178 patients, who received a subcutaneous port catheter between 2002... | 18,791,623 |
Preparation and properties of a novel drug delivery system with both magnetic and biomolecular targeting. | By loading doxorubicin (DOX) on 5-carboxyl-fluorescein (FAM) labeled AGKGTPSLETTP peptide (A54) coupled starch-coated iron oxide nanoparticles (SIONs), we prepared a novel aqueous drug delivery system with both magnetic and biomolecular targeting, which was specific to human hepatocellular carcinoma cell line BEL-7402.... | 18,791,664 |
Transthoracic Collis-Nissen repair for massive type IV paraesophageal hernia. | An 80-year-old woman presented with type IV massive hiatal hernia with intrathoracic upside-down stomach and transverse colon. She was dyspneic and vomited upon consuming food or water. Consequently, she developed aspiration pneumonia. Both esophagoscopy and upper gastrointestinal series demonstrated significant cephal... | 18,791,669 |
Hybrid myocardial revascularization complicated by delayed anastomotic bleeding. | We present a case of hybrid coronary revascularization complicated by delayed bleeding from an anastomotic site. Anastomosis of the left internal mammary artery to the left anterior descending coronary artery was successfully performed via a lateral anterior small thoracotomy. Scheduled subsequent percutaneous coronary... | 18,791,671 |
Glyceraldehyde-derived advanced glycation end products (AGEs). A novel biomarker of postprandial hyperglycaemia in diabetic rats. | There is a growing body of evidence that postprandial hyperglycaemia plays an important role in accelerated atherosclerosis and may be a therapeutic target for preventing cardiovascular disease (CVD) in diabetes. However, there is no convenient biomarker that could reflect cumulative postprandial hyperglycaemia in diab... | 18,791,692 |
In vitro nonenzymatic glycation of guanosine 5'-triphosphate by dihydroxyacetone phosphate. | Dihydroxyacetone phosphate (DHAP) is a glycolytic intermediate that has been found to be significantly elevated in the erythrocytes of diabetic patients and patients with triosephosphate isomerase deficiency. DHAP spontaneously breaks down to methylglyoxal, a potent glycating agent that reacts with proteins and nucleic... | 18,791,706 |
New available SCAR markers: potentially useful in distinguishing a commercial strain of the superior type from other strains of Lentinula edodes in China. | At present, more than 100 strains of Lentinula edodes are cultivated on a commercial scale in China. A simple, reliable, and effective method to distinguish some commercial strains of the superior type from other commercial strains is very important for the Lentinula industry. In this study, 23 commercial strains of L.... | 18,791,710 |
Laparoscopic and conventional appendicectomy in children: outcomes in English hospitals between 1996 and 2006. | Laparoscopic appendicectomy is increasingly used in children. This national retrospective study compared outcomes of paediatric open and laparoscopic appendicectomy. Length of stay, readmission rates and mortality in children undergoing open and laparoscopic appendicectomy in English NHS Trusts between 1 April 1996 and... | 18,791,723 |
Growth-inhibitory effect of a fucoidan from brown seaweed Undaria pinnatifida on Plasmodium parasites. | The present study was undertaken to investigate the inhibitory effects of fucoidan, a sulfated polysaccharide isolated from the edible brown seaweed Undaria pinnatifida, on the growth of Plasmodium parasites. In order to assess the anti-malarial activity of fucoidan, growth inhibition activities were evaluated using cu... | 18,791,738 |
Dynamical density functional theory for colloidal dispersions including hydrodynamic interactions. | A dynamical density functional theory (DDFT) for translational Brownian dynamics is derived which includes hydrodynamic interactions. The theory reduces to the simple Brownian DDFT proposed by Marconi and Tarazona (U. Marini Bettolo Marconi and P. Tarazona, J. Chem. Phys. 110, 8032 (1999); J. Phys.: Condens. Matter 12,... | 18,791,754 |
Studies of membrane topology of mitochondrial cholesterol hydroxylases CYPs 27A1 and 11A1. | Mitochondrial cytochrome P450 enzymes (CYP or P450, EC 1.14.13.15) play an important role in metabolism of cholesterol. CYP27A1 hydroxylates cholesterol at position 27 and, thus, initiates cholesterol removal from many extrahepatic tissues. CYP11A1 is a steroidogenic P450 that converts cholesterol to pregnenolone, the ... | 18,791,760 |
Femoral osteolysis around the unrevised stem during isolated acetabular revision. | Many surgeons treat progressive femoral osteolysis in association with a well-fixed stem with bone grafting but in uncontained proximal defects the graft could get into the joint, raising a question regarding whether the osteolysis can be treated by simple débridement without bone grafting. We investigated whether the ... | 18,791,773 |
Pediatric deformity correction using a multiaxial correction fixator. | Circular fixators have been used successfully to correct multiplanar deformities but are often cumbersome and may be difficult to apply. We determined whether a monolateral fixator, which allows for correction of angular deformity and displacement in three planes, can correct lower extremity deformities to within norma... | 18,791,777 |
Case report: protothecal tenosynovitis. | Protothecosis is a rare infection caused by achlorophyllic algae called Prototheca. Approximately 117 cases have been described in the literature world wide, the majority caused by the species P. wickerhamii. Cutaneous infection is the most common and cases of tenosynovitis are very rare. A local or systemic immunosupp... | 18,791,778 |
Amyand's hernia in premature twins. | Amyand's hernia (AH) is the presence of a normal or inflamed vermiform appendix in an inguinal hernia sac. This condition is unusual in neonates and in infants, and it has not been described in premature twins. We present two 32-day-old biovular twins with a right AH, treated with sparing of the appendix and herniotomy... | 18,791,780 |
Plasma levels of fibroblast growth factor-23 and mineral metabolism in diabetic and non-diabetic patients on chronic hemodialysis. | Fibroblast growth factor (FGF) 23 is a circulating factor that regulates phosphate (P) metabolism. Since higher P levels are associated with vascular calcification, we examined the role of serum FGF-23 levels in P metabolism and vascular calcification in hemodialysis (HD) patients with and without diabetes mellitus (DM... | 18,791,804 |
Methanosarcina as the dominant aceticlastic methanogens during mesophilic anaerobic digestion of putrescible waste. | Taking into account isotope (13)C value a mathematical model was developed to describe the dynamics of methanogenic population during mesophilic anaerobic digestion of putrescible solid waste and waste imitating Chinese municipal solid waste. Three groups of methanogens were considered in the model including unified hy... | 18,791,805 |
Isolation and characterization of a gene encoding cinnamate 4-hydroxylase from Parthenocissus henryana. | Cinnamate 4-hydroxylase (C4H, EC 1.14.13.11) plays an important role in the phenylpropanoid pathway, which produces many economically important secondary metabolites. A gene coding for C4H, designated as PhC4H (GenBank accession no. DQ211885) was isolated from Parthenocissus henryana. The full-length PhC4H cDNA is 1,74... | 18,791,809 |
A pilot study of a family history risk assessment tool for cardiovascular disease. | This study evaluated the effectiveness of using a family history questionnaire to ascertain patients and families at-risk for inherited cardiovascular disease. A questionnaire composed of 21 questions was developed based on the experience of a cardiovascular genetic counselor. This questionnaire was administered to 39 ... | 18,791,812 |
Gastrointestinal symptoms in a sample of children with pervasive developmental disorders. | Objective To evaluate gastrointestinal (GI) problems in a large, well-characterized sample of children with pervasive developmental disorders (PDDs). Methods One hundred seventy two children entering one of two trials conducted by the Research Units on Pediatric Psychopharmacology (RUPP) Autism Network were assessed co... | 18,791,817 |
Non-Newtonian bile flow in elastic cystic duct: one- and three-dimensional modeling. | Bile flow is thought to play an essential role in the pathophysiological genesis of cholelithiasis (gallstone formation) and in gallbladder pain. In this paper, we extend our previous study of the human biliary system (Li et al., 2007, J. Biomech. Eng., 129:164-173) to include two important factors: the non-Newtonian p... | 18,791,826 |
Light-harvesting complexes of vascular plants. | Light-harvesting complexes (LHCs) located in the thylakoid membrane of plant chloroplasts are the collectors of solar radiation that fuel photosynthesis, and thus enable life on our planet. They consist of pigments that are non-covalently bound to light-harvesting proteins (Lhc proteins), which form a family whose memb... | 18,791,846 |
Protein assemblies with palindromic structure motifs. | Symmetric DNA sequence motifs allow the formation of palindromic protein/DNA complexes. Although symmetric protein sequence motifs are less common, recent structural discoveries have unraveled a few protein/protein complexes with palindromic symmetry. Remarkably, symmetric protein/protein complexes can be generated eit... | 18,791,850 |
Synthesis and assessment of molecular recognizability by RP-HPLC of an N-alkyl-beta-Ala-L: -Phe-derived organic phase with self-assembling ability. | An N-alky-beta-Ala-L: -Phe derivative, N'-octadecyl-N ( alpha )-[(N-acryloyl)-beta-alanyl]-L: -phenylalanineamide (1), with a polymerizable head group has been synthesized and telomerized with the silane coupling agent 3-mercaptopropyltrimethoxysilane (MPS). SEM and DSC observations indicated that both 1 and its telome... | 18,791,858 |
Adjusted estimates for time-to-event endpoints. | In the analysis of retrospective data or when interpreting results from a single-arm phase II clinical trial relative to historical data, it is often of interest to show plots summarizing time-to-event outcomes comparing treatment groups. If the groups being compared are imbalanced with respect to factors known to infl... | 18,791,867 |
Numerical modelling of foam Couette flows. | A numerical computation based on a tensorial visco-elasto-plastic model based on continuous mechanics is compared to experimental measurements on liquid foams for a bidimensional Couette flow between two glass plates, both in stationary and transient cases. The main features of the model are elasticity up to a plastic ... | 18,791,872 |
[Why not revisiting tinidazole as potential treatment of odontogenic infections?]. | Tinidazole is a 5-nitroimidazole initially introduced into clinical medicine in 1969 for the treatment of unicellular parasites. Tinidazole offers selective bactericidal activity, not influenced by the inoculum size, against anaerobic bacteria, that make it of theoretical interest against periodontopathogen infections.... | 18,791,873 |
Early counselling and support for patients with mild Alzheimer's disease and their caregivers: a qualitative study on outcome. | The aim of this qualitative study was to identify and analyse the participants' experienced outcome of an intensive structured psychosocial intervention programme with tailored counselling, education and support groups for home-living patients with mild Alzheimer's disease and their spousal caregivers. Data were collec... | 18,791,891 |
Social integration, a sense of belonging and the Cenotaph Service: old soldiers reminisce about Remembrance. | This study explored how war commemorations such as the Cenotaph Service in the UK enable older veterans to benefit from a feeling of integration and belonging gained from both comradeship and acknowledgement from wider society. Focus groups preceded by a video clip of the Cenotaph Service with 45 veterans were used to ... | 18,791,900 |
Exploring dendrimer towards dual drug delivery: pH responsive simultaneous drug-release kinetics. | A major problem associated with conventional leukaemia chemotherapy is the development of resistance that can be surmounted well by combination chemotherapy. The objective of the present investigation is to report a novel technology to load two anti-leukaemic drugs of choice simultaneously inside the PAMAM dendrimer. U... | 18,791,906 |
New operative technique for treatment of arthroscopically-confirmed injury to the scapholunate ligament by volar capsuloplasty augmented with a free tendon graft. | We report how scapholunate (SL) lesions found during arthroscopy were treated using a new palmar operation based on the use of a tendon loop formed using the palmaris longus tendon, with promising preliminary results. Scapholunate instability induced by hyperextension injury was diagnosed and graded arthroscopically. V... | 18,791,908 |
Dietary intake of soy protein and tofu in association with breast cancer risk based on a case-control study. | Soy food and its constituents may protect against breast cancer, but the association between soy intake and decreased breast cancer risk is inconsistent. We evaluated the relationship between breast cancer risk and the dietary intake of soy protein as measured by total soy food and tofu intake. Histologically confirmed... | 18,791,919 |
AlphaIIbG236E causes Glanzmann thrombasthenia by impairing association with beta3. | Glanzmann thrombasthenia (GT) is a recessively inherited bleeding disorder caused by the quantitative or qualitative deficiency of the platelet fibrinogen receptor, integrin alphaIIbbeta3. The N-terminal domain of the alphaIIb subunit is folded in a beta-propeller that plays the role of binding fibrinogen and associati... | 18,791,937 |
Color Doppler US evaluation of feeding artery after balloon angioplasty of the drainage vein in dysfunctional hemodialysis AVF. | The aim of this study was to investigate flow rate and resistive index (RI) parameters of the feeding artery after balloon angioplasty of the drainage vein in dysfunctional hemodialysis arteriovenous fistula (AVF) due to venous stenosis/thrombosis. A cohort of 10 patients with native dysfunctional hemodialysis AVF was ... | 18,791,955 |
[Psychotherapy for traumatized children and adolescents--cognitive-behavioral treatments]. | According to cognitive-behavioral models, both the avoidance of trauma-associated cues, as well as cognitive distortions of the trauma and the initial symptoms thereof lead to and subsequently maintain traumatic disorders. Trauma-focused cognitive behavioral therapy often starts with stabilizing interventions such as r... | 18,791,984 |
Facial nerve aberrations and their implications for cochlear implantation. | Cochlear implantation is a surgical procedure with progressively widening indications in the management of profound deafness. In the majority of cases the operation involves the formation of a posterior tympanotomy for electrode insertion. This process carries documented risks to the mastoid portion of the facial nerve... | 18,791,997 |
Meningitis and cochlear implantation in Scotland. | Meningitis is responsible for a considerable proportion of profoundly deafened children. At the Scottish Cochlear Implant Centre, those attending for cochlear implant assessment with post-meningitic deafness were identified from 1989 to 1999. In those found suitable, findings at surgery were recorded. Meningitis notifi... | 18,791,999 |
Multidimensional LC x LC analysis of phenolic and flavone natural antioxidants with UV-electrochemical coulometric and MS detection. | A comprehensive 2-D LC x LC system was developed for the separation of phenolic and flavone antioxidants, using a PEG-silica column in the first dimension and a C(18) column with porous-shell particles or a monolithic column in the second dimension. Combination of PEG and C18 or C8 stationary phase chemistries provide ... | 18,792,009 |
Construction of a new interface for comprehensive supercritical fluid chromatography x reversed phase liquid chromatography (SFC x RPLC). | The design of a new interface to hyphen high efficiency supercritical fluid chromatography (SFC) and fast RPLC in a comprehensive configuration is described. SFC x RPLC is a viable alternative to normal phase (NP) LC x RPLC and is characterized by high orthogonality. Compared to NPLC x RPLC an additional advantage is t... | 18,792,011 |
Fluorescent magnesium(II) coordination polymeric hydrogel. | A pH and mechano-responsive coordination polymeric gel was developed without the use of long chain hydrophobic groups. The hydrogel was synthesised by reacting the aqueous solution of Mg2+ with the basic aqueous solution of N-(7-hydroxyl-4-methyl-8-coumarinyl)-alanine. The gelation is attributed to the self-aggregation... | 18,792,021 |
New DNA polymerase IIIC inhibitors: 3-subtituted anilinouracils with potent antibacterial activity in vitro and in vivo. | The development of resistance has rendered several antibiotics clinically ineffective, and there is an urgent medical need for potent and safe antibacterials with a novel and valid mode of action. To avoid cross-resistance, they should preferably inhibit targets that are not addressed by established antibiotics. In thi... | 18,792,034 |
Benzimidazolium salts as small, nonpeptidic and BBB-permeable human prolyl oligopeptidase inhibitors. | Prolyl oligopeptidase (POP) is a cytosolic serine peptidase that hydrolyzes proline-containing peptides at the carboxy terminus of proline residues. This peptidase has gained importance as a target for the treatment of cognitive disturbances of patients with neuropsychiatric diseases. Our research addresses the identif... | 18,792,035 |
Glutathione transferase: new model for glutathione activation. | Glutathione transferases are enzymes of the cellular detoxification system that metabolize a vast spectrum of xenobiotic and endobiotic toxic compounds. They are homodimers or heterodimers and each monomer has an active center composed of a G-site in which glutathione (GSH) binds and an H-site for the electrophilic sub... | 18,792,041 |
A dinuclear iron complex based on parallel malonate binding sites: cooperative activation of dioxygen and biomimetic ligand oxidation. | A ligand that offers two parallel malonate binding sites linked by a xanthene backbone, namely, Xanthmal2-, has been utilised to synthesise dinuclear FeII complex [Fe2(Xanthmal)2] (1). The reactivity of 1 in contact with O2 was investigated at -40 degrees C and room temperature. After activation of O2 through interacti... | 18,792,042 |
Growth of three bacteria in arsenic solution and their application for arsenic removal from wastewater. | The present paper compares the arsenic removal capacities of three bacterial strains namely, Ralstonia eutropha MTCC 2487, Pseudomonas putida MTCC 1194 and Bacillus indicus MTCC 4374 form wastewater (simulated acid mine drainage) containing arsenic (As(III):As(V)::1:1), Fe, Mn, Cu and Zn in the concentration of 15 mg/l... | 18,792,057 |
Reliability and validity of the Childhood Cancer Survivor Study Neurocognitive Questionnaire. | Up to 40% of childhood cancer survivors may experience neurocognitive impairment in 1 or more specific domains. As such, regular monitoring has been recommended for patients exposed to cranial irradiation and/or antimetabolite chemotherapy. This study reports the results of a questionnaire developed to identify those s... | 18,792,068 |
Identification of CXCL13 as a new marker for follicular dendritic cell sarcoma. | The homeostatic chemokine CXCL13 is preferentially produced in B-follicles and is crucial in the lymphoid organ development by attracting B-lymphocytes that express its selective receptor CXCR5. Follicular dendritic cells (FDCs) have been identified as the main cellular source of this chemokine in lymphoid organs. Rece... | 18,792,075 |
Early phase of maternal skin carcinogenesis recruits long-term engrafted fetal cells. | During pregnancy, fetal cells enter the maternal circulation. These may be mesenchymal stem cells, haematopoietic or endothelial progenitors, which may persist for decades and be recruited to damaged maternal tissues. Recently, fetal cells were also identified in tumour tissues such as cervical cancer and breast carcin... | 18,792,101 |
Recognition of familiar melodies by adult cochlear implant recipients and normal-hearing adults. | The purpose of this study was to compare melody recognition and pitch perception of adult cochlear implant recipients and normal-hearing adults and to identify factors that influence the ability of implant users to recognize familiar melodies. Forty-nine experienced cochlear implant recipients and 18 normal-hearing adu... | 18,792,110 |
Localization performance of unilateral cochlear implant users for speech, tones and noise. | Bilateral cochlear implants aim to improve sound localization compared to monaural implants, among other potential benefits. Monaural cochlear implants should not support localization in the horizontal plane as there are no interaural level and time difference cues available, although some previous studies have suggest... | 18,792,202 |
Refractory severe facial nerve cross-stimulation and loss of auditory sensation after ten years of uneventful cochlear implant use. A rare and challenging case. | Facial nerve stimulation after cochlear implantation has been well described. When the implant is first activated it is usually possible to 'programme out' the unwanted cross-stimulation. We report an exceptional case of delayed facial nerve stimulation and auditory failure after ten years of uncomplicated implant use.... | 18,792,205 |
Research directions for future generations of cochlear implants. | Physiological and psychophysical research indicates that improved hearing in noise and music appreciation are likely with cochlear implants, with better reproduction of the fine temporospatial patterns of neural response in the auditory pathways due to phase differences in neuron firing patterns as the result of the ba... | 18,792,214 |
Sound localization in patients with unilateral cochlear implants. | To evaluate sound localization ability in totally deaf patients with unilateral cochlear implants and to estimate the ability to improve this function by training. A controlled case series. Nine patients with monaural cochlear implants were asked to identify the source of 50 randomly distributed sound stimuli coming fr... | 18,792,315 |
A comparison of cochlear implant processing strategies in children using speech pattern audiometry. | The aim of this study was to use Speech Pattern Audiometry (SPA) to compare phoneme perception performance between SPEAK and ACE processing strategies with children using the Nucleus 24 cochlear implant. Listeners were evaluated in terms of ability to identify two synthetic word pairs, one signalling a voicing contrast... | 18,792,337 |
Language and theory-of-mind development in prelingually deafened children with cochlear implants: a preliminary investigation. | One cognitive domain in which deaf children are known to lag behind their hearing peers is that of 'theory of mind'. Impoverished early conversational experience and deprivation of discussion about intangible mental states are seen as likely contributors to this deficit. The present study explored the relation between ... | 18,792,371 |
Symposium on Training Programs in Pathology (VII European Congress of Pathology, Valencia, 1979). An introduction to the symposium: participants, aims--the Spanish programme; proposed general conclusions. | The need for learning pathology as a physical substratum of disease is unquestioned. Thus at the undergraduate level opinions vary only on the best time for teaching pathology, the length and the depth of teaching, the degree of integration with clinical disciplines, the use of audiovisual aids, the direct involvement ... | 18,792,466 |
The risk of cancer in relationship to diet. | Globally, colorectal cancer is the leading cause of mortality due to malignant diseases. Probiotics are live microbial food supplements or functional foods containing specific nonpathogenic organisms that beneficially affect the host by improving the intestinal microbial balance. Therefore they can be used as an innova... | 18,792,488 |
The comparative study of metacognition: sharper paradigms, safer inferences. | Results that point to animals' metacognitive capacity bear a heavy burden, given the potential for competing behavioral descriptions. In this article, formal models are used to evaluate the force of these descriptions. One example is that many existing studies have directly rewarded so-called uncertainty responses. Mod... | 18,792,496 |
Evidence against a speed limit in multiple-object tracking. | Everyday tasks often require us to keep track of multiple objects in dynamic scenes. Past studies show that tracking becomes more difficult as objects move faster. In the present study, we show that this trade-off may not be due to increased speed itself but may, instead, be due to the increased crowding that usually a... | 18,792,507 |
An attentional blink for sequentially presented targets: evidence in favor of resource depletion accounts. | Several accounts of the attentional blink (AB) have postulated that this dual-target deficit occurs because of limited-capacity attentional resources being devoted to processing the first target at the expense of the second (resource depletion accounts; e.g., Chun & Potter, 1995). Recent accounts have challenged th... | 18,792,508 |
Memorial consequences of imagination in children and adults. | Recent work with adults suggests that imagination can impair later recall of previously encoded events but can improve recall of subsequently encoded events. The present study examined the memorial consequences of imagination in children. Kindergartners, first and fourth graders, and young adults studied two successive... | 18,792,512 |
Embodied relations are encoded in language. | Studies of embodied cognition have shown that comprehenders process iconic word pairs (attic-basement) more quickly than reverse-iconic pairs (basement-attic) when the pairs are presented to them in a vertical spatial arrangement. This effect disappears in a horizontal spatial arrangement. This has been claimed to show... | 18,792,513 |
Seroprevalence study on the diffusion of the West Nile virus among blood donors, healthcare workers, jockeys, grooms and fowlers, veterinary surgeons and hunters in Messina (Italy). | West Nile virus (WNV) is a mosquito-transmitted flavivirus widely distributed in Africa, Middle East, Asia, Southern Europe and in 1999 was first identified in the United States as a cause of disease in New York City. It mainly circulates among birds, but can infect many species of mammals. Epidemics can occur in rural... | 18,792,530 |
[Epidemiology of cardiac tumors in adults in Lebanon]. | Primary cardiac tumors are rare but potentially fatal. No studies have discussed this issue yet on the national level. We describe the epidemiology of cardiac tumors in adults in Lebanon. The data were taken from the hospitals, the patients and/or their doctors by means of a questionnaire. Fifty-seven cases of cardiac ... | 18,792,552 |
[Evidence for expression of a nifedipine resistant L-type calcium current in human atrial cardiomyocytes]. | In the heart, two types of calcium currents were described, the L- and T-type. In addition to these two types, a dihydropyridine-resistant Ca2+ component has been described to be up-regulated in rat ventricular cardiomyocytes during their differentiation- dedifferentiation process. The aim of our study is to examine if... | 18,792,554 |
[Screening of risk groups for discovering intracranial aneurysms before rupture]. | In development of intracranial aneurysms contribute genetic factors together with smoking, hypertension, diabetes mellitus. Epidemiology studies suggest that as many as 5% of people harbour a cerebral aneurysm by age 75. Rupture of cerebral aneurysm is the most frequent cause of spontaneous subarachnoid haemorrhage (up... | 18,792,572 |
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