title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Carbamazepine and diclofenac: removal in wastewater treatment plants and occurrence in water bodies. | In the aquatic environment, pharmaceuticals have been widely found. Among them, carbamazepine and diclofenac were detected at the highest frequency. To evaluate the worldwide environmental impacts of both drugs, their global consumption volumes are estimated, based on the dose per capita. The metabolites of these pharm... | 18,793,791 |
Right atrium contractility and right ventricular diastolic function assessed by pulsed tissue Doppler imaging can predict brain natriuretic peptide in adults with acquired pulmonary hypertension. | We evaluated right atrial (RA) contractility and right ventricular (RV) diastolic function in adult patients with acquired chronic pulmonary hypertension (PH) by pulsed Tissue Doppler Imaging (TDI) and assessed their relationship with serum brain natriuretic peptide (BNP). Systolic myocardial wave (Sa), early diastolic... | 18,793,807 |
Insulin-like growth factor binding protein-1 is a long-term predictor of heart failure in survivors of a first acute myocardial infarction and population controls. | Only a few studies have investigated the prospective relationship between insulin-like growth factor binding protein-1 (IGFBP-1) and cardiovascular events and the results are conflicting. In this prospective cohort study, we followed both cases, i.e. survivors of a first acute myocardial infarction (AMI) and their age,... | 18,793,810 |
Bilateral adrenal hyperplasia complicated with severe ischemic stroke in a young patient. | A young patient suffered from acute right hemiparesis, facial weakness and Broca's aphasia with multiple brain lesions due to severe hypertension. His evaluation for secondary causes of hypertension revealed hyperaldosteronism due to bilateral adrenal hyperplasia. Treatment is based primarily on spironolactone and ACE ... | 18,793,812 |
Impact of gender in primary prevention of coronary heart disease with statin therapy: a meta-analysis. | Evidence of lipid-lowering from clinical trials that included women is adequate to support their use in secondary prevention in women with known coronary disease. However the role of statin therapy in primary prevention is still controversial, in particular for female gender. The aim of our study is to perform a meta-a... | 18,793,814 |
Effect of capric, lauric and alpha-linolenic acids on the division time distributions of single cells of Staphylococcus aureus. | The effect of non-inhibitory concentrations of capric, lauric and alpha-linolenic acids (C10:0, C12:0 and C18:3 respectively) on the division time distribution of single cells of Staphylococcus aureus was evaluated at pH 7 and pH 5. The effect of the initial cell concentration on the lag time of growing cell population... | 18,793,815 |
Cutaneous manifestations of human toxocariasis. | Human toxocariasis is a parasitic disease characterized by the presence of larvae of the genus Toxocara in human tissues. T canis and T cati, the adult roundworms of which are found in dog and cat intestines, respectively, are the most common causative agents of the disease. Toxocaral larvae usually cause two severe sy... | 18,793,816 |
Investigation of the accumulation of aromatic compounds during biogas production from kitchen waste. | This paper presents laboratory scale studies on the anaerobic degradation of kitchen waste, with a high protein and fat content, using a quasi-continuous co-digestion process. The increased accumulation of non-degraded intermediates as an indication of process imbalances was examined in experiments where the substrate ... | 18,793,837 |
The effect of disk rotational speed on oxygen transfer in rotating biological contactors. | Lab-scale experiments using a synthetic wastewater were carried out to assess the influence of disk rotational speed on oxygen transfer rate in a RBC unit in the presence of biomass. The overall oxygen transfer coefficient (K(L)a) was computed. Five different disk rotational speeds were tested, in the typical RBC opera... | 18,793,838 |
Postoperative analgesia and early rehabilitation after total knee replacement: a comparison of continuous low-dose intravenous ketamine versus nefopam. | The effects of nefopam and ketamine on pain control and rehabilitation after total knee replacement were compared in a prospective, double blinded study. Seventy-five patients were randomly assigned to receive a 0.2mg kg(-1) bolus of nefopam or ketamine, followed by a 120microg kg(-1) h(-1) continuous infusion until th... | 18,793,861 |
Is 'ideal' sitting posture real? Measurement of spinal curves in four sitting postures. | There is a lack of quantitative evidence for spinal postures that are advocated as 'ideal' in clinical ergonomics for sitting. This study quantified surface spinal curves and examined whether subjects could imitate clinically 'ideal' directions of spinal curve at thoraco-lumbar and lumbar regions: (i) flat - at both re... | 18,793,867 |
The Mycobacterium tuberculosis MEP (2C-methyl-d-erythritol 4-phosphate) pathway as a new drug target. | Tuberculosis (TB) is still a major public health problem, compounded by the human immunodeficiency virus (HIV)-TB co-infection and recent emergence of multidrug-resistant (MDR) and extensively drug resistant (XDR)-TB. Novel anti-TB drugs are urgently required. In this context, the 2C-methyl-d-erythritol 4-phosphate (ME... | 18,793,870 |
Overcoming pubic arch interference with free-hand needle placement in men undergoing prostate brachytherapy. | The present study evaluates the postimplant dosimetry when free-hand needles were placed to overcome interference from the pubic arch. A review of all patients who underwent prostate brachytherapy at our institution from 2001 to 2006 was performed. Postimplant dosimetry in men requiring free-hand needle placement was c... | 18,793,877 |
Prion disease: the implications for dentistry. | The aim of this article was to provide the dental community with a brief overview of the characteristics, risk of transmission, and the infection-control implications of prions in dentistry. MEDLINE, EMBASE, CINAHL, The Cochrane Library, and relevant databases were searched, and a targeted internet search was conducted... | 18,793,912 |
Confocal laser scanning microscopy is appropriate to detect viability of Enterococcus faecalis in infected dentin. | The purpose of this study was to explore the potential of confocal laser scanning microscopy (CLSM) for in situ identification of live and dead Enterococcus faecalis in infected dentin. Eight cylindrical dentin specimens were infected with Enterococcus faecalis in BHI for 21 days. After the experimental period, the spe... | 18,793,919 |
Comparison of effects of ProTaper, HeroShaper, and Gates Glidden Burs on cervical dentin thickness and root canal volume by using multislice computed tomography. | The purpose of this study was to compare the effects of 3 different instruments used to prepare curved root canals on the remaining cervical dentin thickness and total amount of dentin removed from root canals during instrumentation by using multislice computed tomography. Mesiobuccal canals of 45 mandibular first mola... | 18,793,924 |
A scanning electron microscopic evaluation of the effectiveness of the F-file versus ultrasonic activation of a K-file to remove smear layer. | The objective of this study was to compare the effectiveness of F-files and ultrasonics to remove the smear layer from instrumented root canals when irrigated with sodium hypochlorite and EDTA. Sixty healthy human premolar teeth were instrumented with ProTaper file series to F3, and the canals were enlarged with Profil... | 18,793,930 |
Therapeutic interventions for vitiligo. | Current treatments for vitiligo, a common pigmentary disorder affecting around 1% of the world's population, are largely unsatisfactory. We sought to report a Cochrane review of all interventions for the treatment of vitiligo. We systematically searched a range of databases for randomized controlled trials. At least tw... | 18,793,940 |
Targeting pro-apoptotic trail receptors sensitizes HeLa cervical cancer cells to irradiation-induced apoptosis. | To investigate the potential of irradiation in combination with drugs targeting the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) death receptor (DR)4 and DR5 and their mechanism of action in a cervical cancer cell line. Recombinant human TRAIL (rhTRAIL) and the agonistic antibodies against DR4 and DR... | 18,793,956 |
RLIP76 in defense of radiation poisoning. | To determine the role of RLIP76 in providing protection from radiation and chemotherapy. In the present report, we used RLIP76 to refer to both the mouse (Ralbp1) and the human (RLIP76) 76-kDa splice variant proteins (RLIP76) for convenience and to avoid confusion. In other reports, Ralbp1 refers to the mouse enzyme (e... | 18,793,957 |
Alpha-1-antitrypsin deficiency panniculitis. | Alpha-1-antitrypsin deficiency is a congenital error of metabolism linked to pulmonary (emphysema) and liver (cirrhosis) disease. Since 1972, panniculitis has been associated with this deficiency, initially related to Weber-Christian syndrome and finally as a differentiated entity. Clinical manifestations typically con... | 18,793,976 |
Sclerosing panniculitis. | Sclerosing panniculitis is a chronic panniculitis characterized by skin induration and hyperpigmentation of one or both legs that often occurs in patients who have venous insufficiency. The indurated plaques are often painful and the legs frequently have a characteristic "inverted wine bottle" appearance. Histopatholog... | 18,793,983 |
Factitial panniculitis. | Factitial panniculitides are subcutaneous tissue injuries produced by external agents or actions. In most cases, factitial panniculitis is caused by self-injection of different substances. Factitial panniculitis can also appear as an iatrogenic consequence of injections of drugs or immunization agents. The clinical fea... | 18,793,986 |
Urodynamic evaluation of the bladder and pelvic floor. | Pelvic floor disorders including lower urinary tract dysfunction are common, and may be evaluated by urodynamic tests, such as cystometry, uroflowmetry, pressure flow studies, electromyography, and video-urodynamics. These urodynamic tests provide objective information regarding the normal and abnormal function of the ... | 18,793,995 |
Hemorrhoids and fissure in ano. | Hemorrhoids and anal fissures are common benign anorectal conditions that form a significant part of a colorectal surgeon's workload. This review summarizes and evaluates the current techniques available in their management. | 18,794,000 |
Economic antecedents of prone infant sleep placement among black mothers. | Black infants die from sudden infant death syndrome at twice the incidence observed among non-Hispanic white infants. Explanations for this disparity include a two-fold greater prevalence of prone (i.e., stomach) infant sleep placement among black caregivers. I test the hypothesis that the contraction of state economie... | 18,794,008 |
Nitric oxide and cardiovascular and renal effects. | Nitric oxide (NO) has multiple protective effects for regulating the cardiovascular and renal systems. The major functions include endothelium-dependent relaxation, anti-inflammatory effects, as well as antihypertrophic and antithrombotic activities. Many of the activities mediated by NO are systematically antagonized ... | 18,794,014 |
Adolescent pregnancy in a Greek public hospital during a six-year period (2000-2005)--a retrospective study. | Adolescent pregnancy constitutes a multidimensional social problem in modern Greece. The purpose of this study was to investigate the trends of teenage childbearing and to determine the relationship between the incidence of teenage pregnancy and immigrant status of the mother. This is a retrospective correlational stud... | 18,794,021 |
Hormonal contraception and blood lead levels in inner-city adolescent girls. | Physiological states of estrogen deficiency can lead to bone demineralization. Lead is stored in bone and may be released into blood during demineralization. The contraceptive injection depomedroxyprogesterone acetate (DMPA) is associated with estrogen deficiency and bone demineralization and, we hypothesized, may be a... | 18,794,022 |
Use/misuse of over-the-counter medications and associated adverse drug events among HIV-infected patients. | Self-medication practices and polypharmacy are common among human immunodeficiency virus (HIV)-infected patients. Inappropriate use of over-the-counter (OTC) medications potentiates the risk for drug misuse and adverse drug events (ADEs). To investigate use and misuse of OTC medications in HIV-infected patients and det... | 18,794,039 |
The Translational Research Working Group developmental pathway for image-based assessment modalities. | The Image-based assessment modality (IM) pathway refers to one of six Translational Research Working Group (TRWG) pathways that, together, describe the core domains of early translational cancer research. This pathway focuses on approaches that are based on the interaction of energy and living organisms to analyze tiss... | 18,794,075 |
Translational Research Working Group developmental pathway for immune response modifiers. | The Translational Research Working Group (TRWG) was created as a national initiative to evaluate the current status of the investment of National Cancer Institute in translational research and envision its future. The Translational Research Working Group conceptualized translational research as a set of six development... | 18,794,077 |
The Translational Research Working Group developmental pathway for lifestyle alterations. | The Translational Research Working Group (TRWG) was created as a national initiative to evaluate the current status of National Cancer Institute's investment in translational research and envision its future. The TRWG conceptualized translational research as a set of six developmental processes or pathways focused on v... | 18,794,079 |
Control of cell growth and survival by enzymes of the fatty acid synthesis pathway in HCT-116 colon cancer cells. | For many tumor cells, de novo lipogenesis is a requirement for growth and survival. A considerable body of work suggests that inhibition of this pathway may be a powerful approach to antineoplastic therapy. It has recently been shown that inhibition of various steps in the lipogenic pathway individually can induce apop... | 18,794,082 |
Chlamydia infection and lymphomas: association beyond ocular adnexal lymphomas highlighted by multiple detection methods. | Chlamydia psittaci (Cp) has been associated to ocular adnexal lymphomas (OAL) with variable geographic distribution. Herein, we used multiple Chlamydia detection tools to identify Cp elementary bodies-containing cell and to assess Cp prevalence in both nodal and extranodal lymphomas. TETR-PCR, immunohistochemistry, imm... | 18,794,089 |
Prognostic impact of bim, puma, and noxa expression in human colon carcinomas. | Proapoptotic BH3-only proteins (Bim, Bad, Bid, Puma, and Noxa) initiate apoptosis by binding to regulatory sites on antiapoptotic Bcl-2 proteins, directly neutralizing their cytoprotective function. Expression of these proteins in colon cancer patients may account for differences in recurrence and survival rates. Archi... | 18,794,091 |
WNT5A expression increases during melanoma progression and correlates with outcome. | Wnt ligands play a major role in development and are important in cancer. Expression microarray analysis correlates one member of this family, WNT5A, to a subclass of melanomas with increased motility and invasion. There are no large studies of clinical samples primarily addressing the importance of WNT5A in melanoma p... | 18,794,093 |
Gene expression profile and angiogenic marker correlates with response to neoadjuvant bevacizumab followed by bevacizumab plus chemotherapy in breast cancer. | To identify biomarkers and gene expression profile signatures to distinguish patients with partial response (PR) from those with stable disease (SD) and progressive disease (PD). Twenty patients with inflammatory breast cancer and one patient with locally advanced breast cancer received one cycle of bevacizumab followe... | 18,794,102 |
Interaction of Muc2 and Apc on Wnt signaling and in intestinal tumorigenesis: potential role of chronic inflammation. | Somatic mutations of the adenomatous polyposis coli (APC) gene are initiating events in the majority of sporadic colon cancers. A common characteristic of such tumors is reduction in the number of goblet cells that produce the mucin MUC2, the principal component of intestinal mucus. Consistent with these observations, ... | 18,794,118 |
CYR61 and alphaVbeta5 integrin cooperate to promote invasion and metastasis of tumors growing in preirradiated stroma. | Radiotherapy is widely used to treat human cancer. Patients locally recurring after radiotherapy, however, have increased risk of metastatic progression and poor prognosis. The clinical management of postradiation recurrences remains an unresolved issue. Tumors growing in preirradiated tissues have an increased fractio... | 18,794,119 |
Systemic targeting of CpG-ODN to the tumor microenvironment with anti-neu-CpG hybrid molecule and T regulatory cell depletion induces memory responses in BALB-neuT tolerant mice. | We have shown that neu transgenic mice are immunotolerant and that immunizations with dendritic cells (DC) pulsed with neu-derived antigens were not able to control tumor growth in these animals. We tested whether, by modulating the tumor microenvironment with Toll-like receptor ligands, it could be possible to induce ... | 18,794,141 |
Cyclin-dependent kinase 3-mediated activating transcription factor 1 phosphorylation enhances cell transformation. | Cyclin-dependent kinase (cdk)-3, a member of the cdk family of kinases, plays a critical role in cell cycle regulation and is involved in G(0)-G(1) and G(1)-S cell cycle transitions. However, the role of cdk3 in cell proliferation, as well as cell transformation, is not yet clearly understood. Here, we report that the ... | 18,794,154 |
Randomized controlled trial comparing laparoscopic ovarian diathermy with clomiphene citrate as a first-line method of ovulation induction in women with polycystic ovary syndrome. | Laparoscopic ovarian diathermy (LOD) is currently accepted as a successful second-line treatment for ovulation induction (OI) in clomiphene citrate (CC)-resistant women with polycystic ovary syndrome (PCOS). The aim of this study was to test the hypothesis that LOD may be superior to CC as a first-line treatment. The s... | 18,794,162 |
Eligibility of rheumatoid arthritis patients for anti-TNF-alpha therapy according to the 2005 recommendations of the French and British Societies for Rheumatology. | Several anti-TNF-alpha prescription guidelines in RA have been published, among which those issued by the British (BSR) and French (SFR) Societies for Rheumatology in 2005 are the most comprehensive. Objectives of the PRISME II survey were to assess and compare eligibility for anti-TNF-alpha therapy of RA patients cons... | 18,794,185 |
The efficacy of an internet-based cognitive-behavioral therapy intervention for child anxiety disorders. | To evaluate the efficacy of an Internet-based cognitive-behavioral therapy (CBT) approach to the treatment of child anxiety disorders. Seventy-three children with anxiety disorders, aged 7-12 years, and their parents were randomly assigned to either an Internet-based CBT (NET) or wait-list (WL) condition. Clinical diag... | 18,794,187 |
In-transit lymph node metastases in breast cancer: a possible source of local recurrence after Sentinel Node procedure. | In-transit lymph node metastases are a common phenomenon in melanoma patients and have been increasingly recognised since the introduction of the Sentinel Node (SN) procedure. To which extent this also occurs in patients with breast cancer has not been studied yet. The aim of this study was therefore to explore the occ... | 18,794,198 |
Oestrogen-receptor-positive breast cancer: towards bridging histopathological and molecular classifications. | The oestrogen receptor (ER) pathway is key for survival and progression in a significant proportion of breast cancers. The ER can be activated by oestrogen or activated due to "crosstalk" with growth factor receptor pathways. Activated ER signals through transcriptional and non-transcriptional mechanisms. Immunohistoch... | 18,794,199 |
What do case-control studies estimate? Survey of methods and assumptions in published case-control research. | To evaluate strategies used to select cases and controls and how reported odds ratios are interpreted, the authors examined 150 case-control studies published in leading general medicine, epidemiology, and clinical specialist journals from 2001 to 2007. Most of the studies (125/150; 83%) were based on incident cases; a... | 18,794,220 |
Using "spinal shrinkage" as a trigger for motivating students to learn about obesity and adopt a healthy lifestyle. | Obesity is a global problem; however, relatively little attention is directed toward preparing and inspiring students of medicine and allied medical sciences to address this serious matter. Students are not routinely exposed to the assessment methods for obesity, its overall prevalence, causative factors, short- and lo... | 18,794,247 |
Association of IS1016 with the hia adhesin gene and biotypes V and I in invasive nontypeable Haemophilus influenzae. | A subset of invasive nontypeable Haemophilus influenzae (NTHI) strains has evidence of IS1016, an insertion element associated with division I H. influenzae capsule serotypes. We examined IS1016-positive invasive NTHI isolates collected as part of Active Bacterial Core Surveillance within the Georgia Emerging Infection... | 18,794,287 |
Txt u ltr: using cellular phone technology to enhance a parenting intervention for families at risk for neglect. | One of the biggest challenges facing home visiting programs aimed at high-risk families is keeping families involved in the intervention. Cellular phones afford the opportunity for home visitors to maintain regular communication with parents between intervention visits and thus retain high-risk families in parenting in... | 18,794,303 |
EPB41L5 functions to post-transcriptionally regulate cadherin and integrin during epithelial-mesenchymal transition. | EPB41L5 belongs to the band 4.1 superfamily. We investigate here the involvement of EPB41L5 in epithelial-mesenchymal transition (EMT) during mouse gastrulation. EPB41L5 expression is induced during TGFbeta-stimulated EMT, whereas silencing of EPB41L5 by siRNA inhibits this transition. In EPB41L5 mutants, cell-cell adh... | 18,794,329 |
Orientation and structure of the Ndc80 complex on the microtubule lattice. | The four-subunit Ndc80 complex, comprised of Ndc80/Nuf2 and Spc24/Spc25 dimers, directly connects kinetochores to spindle microtubules. The complex is anchored to the kinetochore at the Spc24/25 end, and the Ndc80/Nuf2 dimer projects outward to bind to microtubules. Here, we use cryoelectron microscopy and helical imag... | 18,794,333 |
The Tsc1-Tsc2 complex influences neuronal polarity by modulating TORC1 activity and SAD levels. | Neuronal function depends on the specification of neuronal processes as axons or dendrites. In this issue of Genes & Development Choi and colleagues (2485-2495) show that without Tuberous Sclerosis Complex 1 (Tsc1) or Tsc2, molecules linked to the autosomal dominant disease tuberous sclerosis, an increase in the ac... | 18,794,342 |
The nuclear receptor tailless is required for neurogenesis in the adult subventricular zone. | The tailless (Tlx) gene encodes an orphan nuclear receptor that is expressed by neural stem/progenitor cells in the adult brain of the subventricular zone (SVZ) and the dentate gyrus (DG). The function of Tlx in neural stem cells of the adult SVZ remains largely unknown. We show here that in the SVZ of the adult brain ... | 18,794,344 |
Defining the regulatory network of the tissue-specific splicing factors Fox-1 and Fox-2. | The precise regulation of many alternative splicing (AS) events by specific splicing factors is essential to determine tissue types and developmental stages. However, the molecular basis of tissue-specific AS regulation and the properties of splicing regulatory networks (SRNs) are poorly understood. Here we comprehensi... | 18,794,351 |
A novel H19 antisense RNA overexpressed in breast cancer contributes to paternal IGF2 expression. | The H19/IGFf2 locus belongs to a large imprinted domain located on human chromosome 11p15.5 (homologue to mouse distal chromosome 7). The H19 gene is expressed from the maternal allele, while IGF2 is paternally expressed. Natural antisense transcripts and intergenic transcription have been involved in many aspects of e... | 18,794,369 |
A functional interaction between RIP140 and PGC-1alpha regulates the expression of the lipid droplet protein CIDEA. | Nuclear receptors activate or repress target genes depending on the recruitment of coactivators or corepressors. The corepressor RIP140 and the PPAR coactivator 1alpha (PGC-1alpha) both play key roles in the regulated transcription of genes involved in energy homeostasis. We investigated the roles of RIP140 and PGC-1al... | 18,794,372 |
Caspofungin-resistant Candida tropicalis strains causing breakthrough fungemia in patients at high risk for hematologic malignancies. | We identified three cases of C. tropicalis strains causing breakthrough fungemia in allogeneic stem cell recipients receiving caspofungin prophylaxis and treatment. Three genetically unrelated isolates with high echinocandin MICs were identified. Each strain carried a characteristic mutation conferring an amino acid su... | 18,794,386 |
Simultaneous measurement of beat-to-beat carotid diameter and pressure changes to assess arterial mechanical properties. | Use of local arterial distensibility measurements by change in carotid artery diameter divided by pulse pressure has limitations because blood pressure is often taken in a vessel distant or at a time different from where and when change in diameter is taken. In 92 subjects (23 to 91 years of age), carotid artery diamet... | 18,794,405 |
The importance of auricular prostheses for speech recognition. | To examine the effects of an auricular prosthesis on sound levels at the entrance of the ear canal by measuring the auricular prosthesis transfer function (APTF) and to determine the effect of the prosthesis on speech recognition in noisy hearing conditions. Eight prostheses were used to measure the APTF. A microphone ... | 18,794,410 |
Decreased bile duct injury rate during laparoscopic cholecystectomy in the era of the 80-hour resident workweek. | Considerable concern has been raised about the effects of restricted duty hours on surgical training. However, to our knowledge, the effect of the 80-hour resident workweek on operative outcomes after laparoscopic cholecystectomy has not been well studied. To compare the rates of bile duct injury and overall complicati... | 18,794,421 |
Nasal-air conditioning in patients with chronic rhinosinusitis and nasal polyposis. | To compare nasal-air conditioning in patients with chronic rhinosinusitis with nasal polyposis with healthy control subjects without nasal pathologic conditions, to investigate nasal-air conditioning after endoscopic sinus surgery with and without septoplasty and turbinoplasty 4 to 6 weeks after surgery, to examine the... | 18,794,436 |
Induction of collagen by estradiol: difference between sun-protected and photodamaged human skin in vivo. | To evaluate the effectiveness of topical estradiol in stimulating collagen I and III production in naturally aged and photoaged human skin of postmenopausal women and age-matched men. Vehicle-controlled treatment followed by biochemical and immunohistochemical analyses of skin biopsy specimens. Academic referral center... | 18,794,456 |
Variation in care for recurrent nonmelanoma skin cancer in a university-based practice and a veterans affairs clinic. | To learn if treatment of recurrent nonmelanoma skin cancer (NMSC) varied in different practice settings. Prospective cohort study of consecutive patients with recurrent NMSC. A university-based dermatology practice and the dermatology clinic at the affiliated Veterans Affairs Medical Center (VAMC). Conventional therapi... | 18,794,460 |
Site matters: winning the hearts and minds of patients in a cardiology clinic. | In medical care settings, mental health symptoms of depression and distress are associated with poor medical outcomes, yet they are often underrecognized. Authors sought to examine the effect of having immediate mental-health screening in the cardiology clinic. The Patient Health Questionnaire and the Impact of Event S... | 18,794,506 |
Breast cancer and psychosocial factors: early stressful life events, social support, and well-being. | The allostasis theory postulates that stress causes the body to activate physiologic systems in order to maintain stability. The authors sought to examine the relationship between earlier stress and later development of breast cancer (BC). Authors correlated discrete and interactive relationships of stressful life even... | 18,794,509 |
Mania: psychiatric manifestations of the antiphospholipid syndrome. | Antiphospholipid syndrome (APS) is a prothrombotic condition characterized by recurrent vascular thrombosis and/or pregnancy morbidity in the presence of circulating antiphospholipid antibodies. Central nervous system (CNS) involvement is a prominent feature of APS, and many neurological manifestations have been descri... | 18,794,513 |
Prokaryote-eukaryote interactions identified by using Caenorhabditis elegans. | Prokaryote-eukaryote interactions are ubiquitous and have important medical and environmental significance. Despite this, a paucity of data exists on the mechanisms and pathogenic consequences of bacterial-fungal encounters within a living host. We used the nematode Caenorhabditis elegans as a substitute host to study ... | 18,794,525 |
Prospective randomized study comparing docetaxel, estramustine, and prednisone with docetaxel and prednisone in metastatic hormone-refractory prostate cancer. | To assess the efficacy and toxicity of the addition of estramustine to docetaxel (D) for the treatment of metastatic hormone-refractory prostate cancer. One hundred fifty patients were randomly assigned to D alone (35 mg/m(2) on days 2 and 9, every 3 weeks) or D in combination with estramustine (D/E; 280 mg orally thre... | 18,794,543 |
Prognostic significance of disseminated tumor cells in the bone marrow of prostate cancer patients treated with neoadjuvant hormone treatment. | To explore whether the presence of occult disseminated tumor cells (DTCs) in the bone marrow before neoadjuvant hormone therapy influences the prognosis of patients with organ confined prostate cancer treated by radical prostatectomy. Pretreatment bone marrow aspirates from 193 cT (1-4) pN0M0 prostate cancer patients s... | 18,794,550 |
Pharmacologic treatment of low bone density or osteoporosis to prevent fractures: a clinical practice guideline from the American College of Physicians. | The American College of Physicians (ACP) developed this guideline to present the available evidence on various pharmacologic treatments to prevent fractures in men and women with low bone density or osteoporosis. Published literature on this topic was identified by using MEDLINE (1966 to December 2006), the ACP Journal... | 18,794,560 |
PAI-1 and TAFI in inflammatory bowel disease: the yin and yang of the fibrinolytic system. | In both Crohn's disease and ulcerative colitis, the two major forms of inflammatory bowel disease (IBD), an increased risk of thrombotic events has been demonstrated. Pathogenesis of thrombosis is multifactorial as various primary coagulation system abnormalities other than acquired factors have been reported. The fibr... | 18,794,594 |
Prevalence and sociodemographic determinants of uninvestigated dyspepsia in the Czech Republic. | There are no data on the epidemiology of dyspepsia in Central Europe. The aim of this study was to evaluate the prevalence of uninvestigated dyspepsia in a representative sample of the Czech population. A total of 2509 persons, aged 5-100 years, randomly selected from 30 012 individuals in the general population, enter... | 18,794,604 |
A delayed time of the peak tricuspid regurgitation signal: marker of right ventricular dysfunction. | Worsening degrees of tricuspid regurgitation (TR) have been associated with worse outcomes. We investigated the time it takes for the TR jet to attain its maximum peak (tmpTR) with measures of right ventricular (RV) function. Several echocardiographic variables of RV size and function and tmpTR corrected for heart rate... | 18,794,616 |
Cerebral vascular accident in a patient with reactive thrombocytosis: a rare cause of stroke. | Reactive thrombocytosis (RT) is usually a benign process and is not associated with thrombotic or hemorrhagic events We report a case of a young man who suffers a stroke caused by RT, which was secondary to splenectomy, iron deficiency, and infection. : Although rarely documented, RT can be the cause of a major vascula... | 18,794,625 |
The association of Hashimoto disease and Congo red negative amyloidosis. | Systemic amyloidosis which is characterized by extracellular deposition of monoclonal immunoglobulin light chains in various organs may be difficult to diagnose at an early stage, especially when the Congo red stain is negative. We describe herein a case of Congo red negative primary amyloidosis associated with Hashimo... | 18,794,630 |
Australia and New Zealand survey of antimetabolite and steroid use in trabeculectomy surgery. | To assess the pattern of use of antimetabolites and steroids in trabeculectomy surgery among consultant ophthalmologists in Australia and New Zealand. A postal questionnaire of 25 questions regarding current glaucoma practices and antimetabolite and steroid use in trabeculectomy surgery was sent to all practicing Austr... | 18,794,674 |
Internal glaucoma drainage device tube fenestration for uncontrolled postoperative intraocular pressure. | To describe a novel approach to early postoperative intraocular pressure (IOP) control after glaucoma drainage device (GDD) implantation. Two patients with elevated IOP after GDD implantation underwent internal GDD tube fenestration using a 30-gauge needle to perforate the GDD tube. IOP was lowered in each case by over... | 18,794,687 |
Selective laser trabeculoplasty: a review. | The introduction of selective laser trabeculoplasty (SLT) has renewed interest in laser trabeculoplasty for the reduction of intraocular pressure (IOP) in eyes with glaucoma. This review was undertaken to address frequently raised issues pertinent to SLT in clinical practice. On the basis of the peer-reviewed medical l... | 18,794,688 |
Ostomy pouch wear time in the United States. | The purpose of this study was to determine average pouch wear times of persons with an ostomy living in the United States. In this national survey, subjects were identified by ostomy nurses and through ostomy support groups in the United States. Participants responding to a survey represented all 6 geographic regions o... | 18,794,702 |
The effects of time pressure and experience on nurses' risk assessment decisions: a signal detection analysis. | Time pressure and, occasionally, suboptimal assessment decisions are features of nursing in acute care. To explore the effect of generic and specialist clinical experience on the ability to detect the need to take action in acute care and the impact of time pressure on nurses' decision-making performance. Experienced a... | 18,794,714 |
Reducing my risk of intrusion: an intention of old homebound women who live alone. | In assessing home safety for older persons, nurses have checked home security or assessed fear of crime but neglected to explore intentions to reduce the risk of intrusion. To describe the intentions of old homebound women relative to reducing the risk of intrusion. A descriptive phenomenological method was used. The 4... | 18,794,719 |
Genetic and gene expression studies implicate renin and endothelin-1 in edema caused by peroxisome proliferator-activated receptor gamma agonists. | Peroxisome proliferator-activated receptor gamma (PPARgamma) agonists can cause peripheral edema in susceptible individuals. To investigate the mechanistic basis underlying this adverse event, we performed a candidate gene analysis of patients enrolled in clinical trials of muraglitazar, an investigational PPARalpha/ga... | 18,794,727 |
Preventable hospital-acquired conditions: the whys and wherefores. | The changes to the Centers for Medicare & Medicaid Services (CMS) Inpatient Prospective Payment System published in the Federal Register (, Vol. 72, No. 162) on August 22, 2007, introduced the term preventable "hospital-acquired conditions" (HACs). These printed rules and regulations came about through a provision ... | 18,794,745 |
In vitro disc pressure profiles below scoliosis fusion constructs. | Biomechanical human cadaveric study comparing straight and scoliotic spines with healthy and degenerated L4/5 discs. To describe the biomechanical environment of discs under various spinal alignments by measuring the coronal intradiscal pressure profiles. Abnormal loading of the lumbar discs in the concavity of scoliot... | 18,794,754 |
Adolescent idiopathic scoliosis and exercising: is there truly a liaison? | Cross-sectional observational study. Evaluation and comparison of the prevalence of adolescent idiopathic scoliosis (AIS) among 2 groups of patients (athletes and nonathletes) to determine whether athletic activities are related to the development of AIS. The potential association between AIS and exercising remains unc... | 18,794,756 |
Influence of sacral morphology in developmental spondylolisthesis. | A radiographic study was conducted to investigate sacral morphology in a children and adolescent population with developmental L5-S1 spondylolisthesis. To determine the relationship between sacral morphology and developmental L5-S1 spondylolisthesis. The morphology of the adult sacrum has been recently shown to be abno... | 18,794,760 |
Isolation and characterization of phenolic compounds from the leaves of Salix matsudana. | A bioassay-guided in vitro screen has revealed that a 70% methanol extract of the leaves of Salix matsudana shows considerable inhibitory activity against cyclooxygenases (COX-1 and COX-2). A subsequent phytochemical study led to the isolation of a new flavonoid, matsudone A (1), together with five known flavonoids--lu... | 18,794,770 |
Chemical and enzymatic approaches to carbohydrate-derived spiroketals: di-D-fructose dianhydrides (DFAs). | Di-D-fructose dianhydrides (DFAs) comprise a unique family of stereoisomeric spiro-tricyclic disaccharides formed upon thermal and/or acidic activation of sucrose- and/ or D-fructose-rich materials. The recent discovery of the presence of DFAs in food products and their remarkable nutritional features has attracted con... | 18,794,777 |
Amifostine protection against mitomycin-induced chromosomal breakage in fanconi anaemia lymphocytes. | Fanconi anaemia (FA) is a rare genetic chromosomal instability syndrome caused by impairment of DNA repair and reactive oxygen species (ROS) imbalance. This disease is also related to bone marrow failure and cancer. Treatment of these complications with radiation and alkylating agents may enhance chromosomal breakage. ... | 18,794,784 |
Uremic lung: new insights into a forgotten condition. | The high mortality rate of acute kidney injury (AKI) despite advances in dialysis led to a renewed appreciation of the impact of AKI on distant organ dysfunction. Mechanistic studies demonstrated that AKI induces increased lung vascular permeability, soluble and cellular inflammation, and dysregulated salt and water ch... | 18,794,816 |
Sparse odor representation and olfactory learning. | Sensory systems create neural representations of environmental stimuli and these representations can be associated with other stimuli through learning. Are spike patterns the neural representations that get directly associated with reinforcement during conditioning? In the moth Manduca sexta, we found that odor present... | 18,794,840 |
Phosphorylation switches the general splicing repressor SRp38 to a sequence-specific activator. | SRp38 is an atypical SR protein that functions as a general splicing repressor when dephosphorylated. We now show that phosphorylated SRp38 functions as a sequence-specific splicing activator. Unlike characterized splicing activators, SRp38 functions in the absence of other SR proteins but requires a cofactor for activ... | 18,794,844 |
Asymmetric caging in soft colloidal mixtures. | The long-standing observations that different amorphous materials exhibit a pronounced enhancement of viscosity and eventually vitrify on compression or cooling continue to fascinate and challenge scientists, on the ground of their physical origin and practical implications. Glass formation is a generic phenomenon, obs... | 18,794,859 |
Optogenetic analysis of synaptic function. | We introduce optogenetic investigation of neurotransmission (OptIoN) for time-resolved and quantitative assessment of synaptic function via behavioral and electrophysiological analyses. We photo-triggered release of acetylcholine or gamma-aminobutyric acid at Caenorhabditis elegans neuromuscular junctions using targete... | 18,794,862 |
CDK8 is a colorectal cancer oncogene that regulates beta-catenin activity. | Aberrant activation of the canonical WNT/beta-catenin pathway occurs in almost all colorectal cancers and contributes to their growth, invasion and survival. Although dysregulated beta-catenin activity drives colon tumorigenesis, further genetic perturbations are required to elaborate full malignant transformation. To ... | 18,794,900 |
Genetic co-transfer of CCR7 ligands enhances immunity and prolongs survival against virulent challenge of pseudorabies virus. | The CC chemokine receptor 7 (CCR7) and cognate CCR7 ligands, CCL19 and CCL21, help establish microenvironments in lymphoid tissue that can facilitate encounters between naive T cells and mature dendritic cells (DCs). This study was conducted to determine if CCR7 ligands can augment the immunogenicity of a DNA vaccine t... | 18,794,906 |
Designing pharmacogenetic projects in industry: practical design perspectives from the Industry Pharmacogenomics Working Group. | Pharmacogenetic association studies have the potential to identify variations in DNA sequence which impact drug response. Identifying these DNA variants can help to explain interindividual variability in drug response; this is the first step in personalizing dosing and treatment regimes to a patient's needs. There are ... | 18,794,908 |
Symbiotic diversity in marine animals: the art of harnessing chemosynthesis. | Chemosynthetic symbioses between bacteria and marine invertebrates were discovered 30 years ago at hydrothermal vents on the Galapagos Rift. Remarkably, it took the discovery of these symbioses in the deep sea for scientists to realize that chemosynthetic symbioses occur worldwide in a wide range of habitats, including... | 18,794,911 |
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