title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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[Results of the operative treatment of the ruptured aneurysm: prospective clinical study]. | Aneurysmal subarachnoid hemorrhage (SAH) is a dramatic, frequently fatal event. With the incidence of 10 to 15 in 100 000 and a total mortality which even today is 40-50%, it represents a significant problem. Early surgical care for the hemorrhaging aneurysms has, without doubt, an importance in prevention of the ruptu... | 18,792,579 |
Identifying variables that predict falling asleep at the wheel among long-haul truck drivers. | Analysis of data from 843 long-haul truck drivers was conducted to determine the variables that predicted falling asleep at the wheel. Demographics, sleep-specific questions, and the Epworth Sleepiness Scale were used for analysis. More than 25% of the participants (n = 247) scored 10 or higher on the Epworth Sleepines... | 18,792,612 |
[True aneurysm of common digital artery--case report]. | Aneurysms of digital arteries are considered to be rarity. They could be true or false. False aneurysms are usually the result of penetrating trauma, while the causes of development of true aneurysms are various, such as blunt trauma, and rarely atherosclerosis, vasculitis and infection. Also, they can be idiopathic. R... | 18,792,628 |
[Impact of valproates on haemostasis and blood cell count in children]. | Epilepsy is a highly prevalent disease affecting 0.5-1.5% of the world's population. One of the most frequently used antiepileptics are valproates. These medicines show a negative impact on haemostasis and peripheral blood count. The objective of the study was to examine the negative impact of valproates on haemostasis... | 18,792,624 |
[Detection of bone marrow-derived cells in neointimal thickening in the rat carotid artery by nested polymerase chain reaction]. | The bone marrow origin of cells involved in neointimal formation after injury of the luminal surface of the vessel was confirmed by highly sensitive nested polymerase chain reaction on isolated vascular wall cells. The model of intimal hyperplasia after balloon angioplasty of the carotid artery in radiation bone marrow... | 18,792,640 |
Integrative Self-Knowledge Scale: correlations and incremental validity of a cross-cultural measure developed in Iran and the United States. | The authors used Iranian (N = 723) and American (N = 900) samples to develop an Integrative Self-Knowledge Scale for measuring a temporally integrated understanding of processes within the self. They administered this new instrument, the Mindfulness Scale (K. W. Brown & R. M. Ryan, 2003), the Reflective and Experie... | 18,792,651 |
Reproductive interference between animal species. | Although sexual interactions between species (reproductive interference) have been reported from a wide range of animal taxa, their potential for determining species coexistence is often disregarded. Here, we review evidence from laboratory and field studies illustrating that heterospecific sexual interactions are freq... | 18,792,662 |
Building type study 883: Introduction: Health care. Flex and flow. | Hospital owners know that spalike environments mean shorter, more healing hospital stays, and flexible and expandable facilities are essential for growing communities. Enter the architects. | 18,792,663 |
[Impact of the anxiety characteristics and depression on clinical aspects and quality of life in patients with irritable bowel syndrome]. | Anxiety and depression have been related with seeking medical care by IBS patients, however their impact over the clinical characteristics and health related quality of life (HRQOL) of the patients, is unknown. To evaluate the impact of these traits over the symptoms, number of consultations and HRQOL in IBS. Consecuti... | 18,792,667 |
The two-component network and the general stress sigma factor RpoS (sigma S) in Escherichia coli. | The general stress sigma factor RpoS (sigma s) is induced during entry into stationary phase and in response to multiple stress conditions. RpoS is regulated at the levels of transcription, translation, proteolysis and protein activity. A key factor in RpoS control is the two-component response regulator RssB, which ac... | 18,792,681 |
Small RNAs controlled by two-component systems. | Two-component systems (TCSs) allow bacteria to monitor diverse environmental cues and to adjust gene expression accordingly at the transcriptional level. It has been recently recognized that prokaryotes also regulate many genes and operons at a posttranscriptional level with the participation of small, noncoding RNAs w... | 18,792,682 |
Adhesive luting of all-ceramic restorations--the impact of cementation variables and short-term water storage on the strength of a feldspathic dental ceramic. | To investigate the impact of resin cement luting variables and short-term water storage on the strength of an adhesively luted all-ceramic restorative material. An understanding of the strengthening mechanisms will result in optimisation of operative techniques and materials selection criteria. The "fit" surfaces of 48... | 18,792,699 |
Influence of free-hand vs uniform irradiation on tensile bond strength in Er:YAG-lased dentin. | To compare effects of free-hand and mechanically applied uniform irradiation on tensile bond strength of 4-META/MMA-TBB resin to Er:YAG laser-irradiated dentin using an X-Y moving stage. Three different laser conditions were evaluated: 1.0 W, 100 mJ/pulse, 10 pps; 1.0 W, 50 mJ/pulse, 20 pps; 1.0 W, 33 mJ/pulse, 30 pps.... | 18,792,700 |
Reshaping students' attitudes toward individuals with mental illness through a clinical nursing clerkship. | The purpose of this study was to evaluate the degree to which a psychiatric clinical clerkship alters nursing students' attitudes toward individuals with mental illness. The goal of the 4-week clerkship is to provide students with the knowledge, skills, and professional attitudes that will enable them to care for indiv... | 18,792,706 |
Back to the future with hands-on science: students' perceptions of learning anatomy and physiology. | This article examines student perceptions of learning related to anatomy and physiology in a bachelor of nursing program. One strategy to teach the sciences is simulated learning, a technology that offers exciting potential. Virtual environments for laboratory learning may offer numerous benefits: teachers can convey i... | 18,792,709 |
Self-assembly drives quantum dot photoluminescence. | Engineering the spectral properties of quantum dots can be achieved by a control of the quantum dots organization on a substrate. Indeed, many applications of quantum dots as LEDs are based on the realization of a 3D architecture of quantum dots. In this contribution, we present a systematic study of the quantum dot or... | 18,792,763 |
Characterization and membrane gene-based phylogenetic analysis of avian infectious bronchitis virus Chinese strain HH06. | A Chinese isolate of avian infectious bronchitis virus (IBV) designated HH06 was isolated from the kidney tissues of a chicken flock experiencing an outbreak of nephritis. In vivo pathogenicity of the IBV isolate HH06 was determined by inoculating specific pathogen-free (SPF) chickens. The clinical signs and related gr... | 18,792,774 |
Coordinate expression of the human pregnancy-specific glycoprotein gene family during induced and replicative senescence. | Pregnancy-specific glycoproteins (PSGs) comprise a family of highly similar polypeptides encoded by 11 transcriptionally active genes that compactly cluster on band 19q13.2. All members of the PSG family were found to be markedly up-regulated by addition of 5-bromodeoxyuridine in HeLa cells. Similarly, all of the membe... | 18,792,801 |
Association between the G1001C polymorphism in the GRIN1 gene promoter and schizophrenia in the Iranian population. | Schizophrenia is a complex genetic disorder to which genetic variation in the glutamatergic signaling pathways is believed to play a substantial role in the etiology of the disease. Association studies have implicated the N-methyl-D-aspartate receptor subunit gene, GRIN1, as a candidate gene for schizophrenia. In this ... | 18,792,810 |
Evolution of antimicrobial susceptibility patterns of aerobic and facultative gram-negative bacilli causing intra-abdominal infections: results from the SMART studies 2003-2007. | Study for Monitoring Antimicrobial Resistance Trends (SMART) is an ongoing global antimicrobial surveillance program focused on clinical isolates from intra-abdominal infections (IAI). The objective of this subanalysis was to assess the evolution of the antimicrobial susceptibility patterns among aerobic and facultativ... | 18,792,817 |
Knowing where but not what: impaired thematic roles and spatial language. | We describe case J.P. who, following a left inferior frontal lesion, made frequent role confusions in comprehension and production (e.g., saying "The boy kicks the girl" for a picture showing a girl kicking a boy). J.P.'s preserved ability to judge the grammaticality of sentences rules out a syntactic deficit as the pr... | 18,792,829 |
Computational study of growth and remodelling in the aortic arch. | Opening angles (OAs) are associated with growth and remodelling in arteries. One curiosity has been the relatively large OAs found in the aortic arch of some animals. Here, we use computational models to explore the reasons behind this phenomenon. The artery is assumed to contain a smooth muscle/collagen phase and an e... | 18,792,831 |
A community study of psychosocial functioning and weight in young children and adolescents. | Children with either underweight or overweight may be at risk for mental health problems and require mental health service use. The present study investigated the relationship between weight status and psychosocial dysfunctioning in children of two different age groups (5-6 and 13-14 years). Using height and weight mea... | 18,792,853 |
Cognitive profiles of healthy siblings of schizophrenia patients: application of the cognitive domains of the MATRICS consensus battery. | Even though a large body of data suggests the presence of various types of cognitive deficits in the unaffected relatives of schizophrenia patients, more study is needed to clarify the comparative sensitivities of specific cognitive measures for relative-control differences. In this study, the authors compared the cogn... | 18,792,857 |
[Postoperative cognitive dysfunction in geriatric patients]. | Postoperative cognitive dysfunction occurs in geriatric patients after major operations and influences morbidity and mortality of these patients. Clinical observations and neuropsychological tests can be used to diagnose cognitive disorders after an operation. Until today no specific medical treatment is known for the ... | 18,792,864 |
[Incident reporting systems in anesthesiology--methods and benefits using the example of PaSOS]. | Preventing patient harm is one of the main tasks for the field of anesthesiology from early on. With the introduction of the national German incident reporting system PaSOS, which is hosted by the German anesthesia society, anesthesiology is again leading the field of patient safety. Important elements, success factors... | 18,792,866 |
Effects of acute and chronic attenuation of postprandial hyperglycemia on postglucose-load endothelial function in insulin resistant individuals: is stimulation of first phase insulin secretion beneficial for the endothelial function? | The aim of the study is to determine if attenuation of postprandial hyperglycemia, by acutely and chronically enhancing postprandial insulin secretion in insulin-resistant individuals, improves the endothelial dysfunction. We assessed postoral glucose-load endothelial function in 56 insulin-resistant subjects with the ... | 18,792,871 |
The role of inflammation in vascular insulin resistance with focus on IL-6. | The present review focuses on the possible role of interleukin-(IL)-6 in vascular insulin resistance. The endothelium plays an important role in regulating the tone of the vasculature by releasing nitric oxide (NO) to the smooth muscles of the vessels, thereby regulating the distribution of blood flow to the various ti... | 18,792,875 |
Leptin decreases postprandially in people with type 2 diabetes, an effect reduced by the cooking method. | Leptin modulates satiety and increases in obesity and type 2 diabetes mellitus in parallel with leptin resistance. Postprandial leptin regulation has been previously postulated to depend on meal composition, but data are controversial. The hypothesis of our study was that in people with type 2 diabetes mellitus, a post... | 18,792,885 |
Effects of postpartum exercise program on fatigue and depression during "doing-the-month" period. | This study explored the effectiveness of an exercise program on reducing levels of fatigue and depression among postpartum women who were "doing-the-month" in a maternity center in Taiwan. Previous studies related to postpartum have focused on depression rather than women's feelings of fatigue, and no study related to ... | 18,792,887 |
Role of the feline immunodeficiency virus L-domain in the presence or absence of Gag processing: involvement of ubiquitin and Nedd4-2s ligase in viral egress. | RNA-enveloped viruses bud from infected cells by exploiting the multivesicular body (MVB) pathway. In this context, ubiquitination of structural viral proteins and their direct interaction with cellular factors involved in the MVB biogenesis through short proline rich regions, named late domains (L-domains), are crucia... | 18,792,916 |
Oxidation products of polyunsaturated fatty acids in infant formulas compared to human milk--a preliminary study. | Information about lipid oxidation in fresh and stored human milk compared with infant formulas is scarce. We aimed to assess n-6 and n-3 PUFA oxidation in these milks by measuring the 4-hydroxynonenal (4-HNE) and 4-hydroxyhexenal (4-HHE) content. Human milk samples (n = 4), obtained from volunteer mothers, were analyze... | 18,792,926 |
The Gene Ontology (GO) project: structured vocabularies for molecular biology and their application to genome and expression analysis. | Scientists wishing to utilize genomic data have quickly come to realize the benefit of standardizing descriptions of experimental procedures and results for computer-driven information retrieval systems. The focus of the Gene Ontology project is three-fold. First, the project goal is to compile the Gene Ontologies; str... | 18,792,943 |
Creating databases for biological information: an introduction. | The essence of bioinformatics is dealing with large quantities of information. Whether it be sequencing data, microarray data files, mass spectrometric data (e.g., fingerprints), the catalog of strains arising from an insertional mutagenesis project, or even large numbers of PDF files, there inevitably comes a time whe... | 18,792,944 |
Biodegradable honeycomb collagen scaffold for dermal tissue engineering. | Tissue engineering requires a mechanically stable, biocompatible, and biodegradable scaffold that permits cell adherence and proliferation, allows preservation of cell-specific properties, and suitable for surgical implantations. In this study, honeycomb collagen sheet was used for three-dimensional (3D) cultures of hu... | 18,792,951 |
Laurin-Sandrow syndrome: review and redefinition. | We report on a newborn infant with characteristics of Laurin-Sandrow syndrome (LSS). She had hypertelorism, flat nose with grooved collumella, "V" shaped mouth with thin lips, 7 well-recognized and fused digits and 1 additional postaxial bilateral appendix on each hand. The right and left feet had 12 and 11 toes, respe... | 18,792,985 |
Time-of-day differences in dopamine clearance in the rat medial prefrontal cortex and nucleus accumbens. | Circadian rhythms influence cocaine-seeking behavior in rats, and this behavior may be mediated by variability in the rate of extracellular dopamine clearance across the day:night cycle. We used rotating disk electrode voltammetry to examine dopamine clearance and inhibition of clearance by cocaine in the rat medial pr... | 18,792,987 |
Peace psychology for a peaceful world. | Although the literature in peace psychology has been growing rapidly, many American psychologists are unaware of how conflict is resolved and peace is conceptualized and achieved. This article reviews the long history and broadening scope of peace psychology and introduces a model of peace that is useful for organizing... | 18,793,041 |
Locomotor experience affects self and emotion. | Two studies investigated the role of locomotor experience on visual proprioception in 8-month-old infants. Visual proprioception refers to the sense of self-motion induced in a static person by patterns of optic flow. A moving room apparatus permitted displacement of an entire enclosure (except for the floor) or the si... | 18,793,056 |
The prevalence of perceived discrimination among African American and Caribbean Black youth. | The present study examined ethnic, gender, and age differences in perceived discrimination and the association between perceived discrimination and psychological well-being in a nationally representative sample of Black adolescents. Data are from the National Survey of African Life (NSAL), which includes 810 African Am... | 18,793,063 |
Follow-up of HIV-infected women diagnosed by antenatal screening in Barbados from 1996-2004. | A follow-up study was undertaken to analyze the impact of the early diagnosis of HIV in women by antenatal voluntary counseling and testing (VCT) by way of making a difference to their health status and the social behavior of these women. This is a descriptive study. The study population included all HIV-infected women... | 18,793,086 |
Assuring the quality of clinical microbiology test results. | The role of microbiology laboratories in the care of patients with suspected or known infections has been described in previous articles in this series of medical microbiology updates. This review addresses the broader role of clinical microbiology laboratories in the quality of care and patient safety. The importance ... | 18,793,099 |
Monogamy and the battle of the sexes. | Sexual conflict has been suggested to be important in the evolution of reproductive traits, with much recent theoretical and empirical evidence emphasizing its role in generating sexually antagonistic coevolution in the context of promiscuous mating. Here we shift attention to the role of sexual conflict in a monogamou... | 18,793,102 |
Cellular and molecular aspects of rhabdovirus interactions with insect and plant hosts. | The rhabdoviruses form a large family (Rhabdoviridae) whose host ranges include humans, other vertebrates, invertebrates, and plants. There are at least 90 plant-infecting rhabdoviruses, several of which are economically important pathogens of various crops. All definitive plant-infecting and many vertebrate-infecting ... | 18,793,103 |
Off-label use of stents: bare-metal versus drug-eluting stents. | Drug-eluting stents (DES) became the default strategy for percutaneous revascularization due to their improved intermediate-term outcomes when compared with bare-metal stents (BMS) in the pivotal randomized, controlled trials. The excellent results of DES in on-label or US FDA-approved indications led to extrapolation ... | 18,793,112 |
Cardiovascular disease prevention tailored for women. | Cardiovascular disease prevention is most effective when it is tailored for individual risk, since the benefit of any preventive intervention should outweigh its potential side effects and costs. Recognition of important gender differences in cardiovascular disease prevention has led to the formulation of specific guid... | 18,793,115 |
Modelling the dynamics of signalling pathways. | In the present chapter we discuss methodologies for the modelling, calibration and validation of cellular signalling pathway dynamics. The discussion begins with the typical range of techniques for modelling that might be employed to go from the chemical kinetics to a mathematical model of biochemical pathways. In part... | 18,793,120 |
Parameter estimation and optimal experimental design. | Mathematical models are central in systems biology and provide new ways to understand the function of biological systems, helping in the generation of novel and testable hypotheses, and supporting a rational framework for possible ways of intervention, like in e.g. genetic engineering, drug development or treatment of ... | 18,793,133 |
Much to know about proteolysis: intricate proteolytic machineries compromise essential cellular functions. | Proteolysis has traditionally been considered as a radical way to terminate the function of a protein. However, protein destruction also is the starting point for many processes as they can only occur when the way has been cleared for the action of other proteins. Protein destruction can occur virtually in all compartm... | 18,793,136 |
Chaperone-driven proteasome assembly. | Assembly of the 34-subunit, 2.5 MDa 26S proteasome is a carefully choreographed intricate process. It starts with formation of a seven-membered alpha-ring that serves as a template for assembly of the complementary beta-ring-forming 'half-proteasomes'. Dimerization results in a latent 20S core particle that can serve f... | 18,793,141 |
Is there an alternative to the proteasome in cytosolic protein degradation? | While it is clear that the proteasome is the major player in degradative proteolysis in the nucleus and cytosol, there is a lack of complete agreement on whether there are alternative proteolytic pathways or activities responsible for a significant degradation of cytosolic/nuclear substrates. Particularly relevant is t... | 18,793,147 |
Lipases in the pancreatic beta-cell: implications for insulin secretion. | Lipids have been implicated in beta-cell stimulus-secretion coupling. In such a role, lipases in beta-cells would be required to generate lipid coupling factors. We have shown previously that glucose stimulates lipolysis in rodent islets. In addition, lipolysis and diacylglycerol lipase activity in islets are abolished... | 18,793,156 |
Significance of protein crowding, order and mobility for photosynthetic membrane functions. | Natural photosynthesis requires diffusion-based processes either for the functional communication of protein complexes or for the adaptation, maintenance and biogenesis of the photosynthetic apparatus. A conceptual problem with lateral diffusion in photosynthetic membranes arises from the fact that these membranes are ... | 18,793,171 |
The role of multihaem cytochromes in the respiration of nitrite in Escherichia coli and Fe(III) in Shewanella oneidensis. | The periplasmic nitrite reductase system from Escherichia coli and the extracellular Fe(III) reductase system from Shewanella oneidensis contain multihaem c-type cytochromes as electron carriers and terminal reductases. The position and orientation of the haem cofactors in multihaem cytochromes from different bacteria ... | 18,793,179 |
Wine yeasts for the future. | International competition within the wine market, consumer demands for newer styles of wines and increasing concerns about the environmental sustainability of wine production are providing new challenges for innovation in wine fermentation. Within the total production chain, the alcoholic fermentation of grape juice by... | 18,793,201 |
Mexiletine for refractory chronic daily headache: a report of nine cases. | To describe the use of mexiletine in the treatment of chronic daily headache in a refractory headache population. Intravenous lidocaine is a novel treatment for chronic daily headache with medication overuse and SUNCT syndrome. Mexiletine is a similar but orally active anti-arrhythmic that has been demonstrated to be a... | 18,793,209 |
Regulation of macrophage nitric oxide production by the protein tyrosine phosphatase Src homology 2 domain phosphotyrosine phosphatase 1 (SHP-1). | Nitric oxide (NO) is a potent molecule involved in the cytotoxic effects mediated by macrophages (MØ) against microorganisms. We previously reported that Src homology 2 domain phosphotyrosine phosphatase 1 (SHP-1)-deficient cells generate a greater amount of NO than wild-type cells in response to interferon-gamma (IFN-... | 18,793,215 |
A ceramide-1-phosphate analogue, PCERA-1, simultaneously suppresses tumour necrosis factor-alpha and induces interleukin-10 production in activated macrophages. | Tight regulation of the production of the key pro-inflammatory cytokine tumour necrosis factor-alpha (TNF-alpha) is essential for the prevention of chronic inflammatory diseases. In vivo administration of a synthetic phospholipid, named hereafter phospho-ceramide analogue-1 (PCERA-1), was previously found to suppress l... | 18,793,216 |
Thoracoscopic pulmonary vein isolation after previous percutaneous atrial septal defect closure. | Atrial fibrillation (AF) is the main cause of morbidity among patients over 40 years of age with atrial septal defect (ASD). The closure of ASD in older patients does not decrease the occurrence of AF.(1-3) However, percutaneous ASD closure devices eliminate the possibility of a transseptal approach for future catheter... | 18,793,225 |
Occurrence of enteric viruses in shellfish and relation to climatic-environmental factors. | To investigate the presence of enteric viruses [hepatitis A (HAV) and norovirus (NoV)] in shellfish harvested from the deltaic area of the Po river in relation to environmental factors. Fortnightly sampling of shellfish was carried out in two lagoon areas (category B production areas) and one sea area (category A). Env... | 18,793,257 |
Plant pharming of a full-sized, tumour-targeting antibody using different expression strategies. | The aims of this work were to obtain a human antibody against the tumour-associated antigen tenascin-C (TNC) and to compare the yield and quality of plant-produced antibody in either stable transgenics or using a transient expression system. To this end, the characterization of a full-sized human immunoglobulin G (IgG)... | 18,793,269 |
Development and growth in very preterm infants in relation to NIDCAP in a Dutch NICU: two years of follow-up. | To study development and growth in relation to newborn individualized developmental and assessment program (NIDCAP) for infants born with a gestational age of less than 30 weeks. Developmental outcome of surviving infants, 25 in the NIDCAP group and 24 in the conventional care group, in a prospective phase-lag cohort s... | 18,793,293 |
Complex seasonal patterns of primary producers at the land-sea interface. | Seasonal fluctuations of plant biomass and photosynthesis are key features of the Earth system because they drive variability of atmospheric CO(2), water and nutrient cycling, and food supply to consumers. There is no inventory of phytoplankton seasonal cycles in nearshore coastal ecosystems where forcings from ocean, ... | 18,793,308 |
Diversity of deep-water cetaceans in relation to temperature: implications for ocean warming. | Understanding the effects of natural environmental variation on biodiversity can help predict response to future anthropogenic change. Here we analyse a large, long-term data set of sightings of deep-water cetaceans from the Atlantic, Pacific and Indian Oceans. Seasonal and geographic changes in the diversity of these ... | 18,793,309 |
Yeast Yak1 kinase, a bridge between PKA and stress-responsive transcription factors, Hsf1 and Msn2/Msn4. | Hsf1 and Msn2/Msn4 transcription factors in Saccharomyces cerevisiae play important roles in cellular homeostasis by activating gene expression in response to multiple stresses including heat shock, oxidative stress and nutrient starvation. Although it has been known that nuclear import of Msn2 is inhibited by PKA-depe... | 18,793,336 |
PDCD4 gene silencing in gliomas is associated with 5'CpG island methylation and unfavourable prognosis. | Programmed cell death 4 (PDCD4) is a newly described tumour suppressor that inhibits oncogenesis by suppressing gene transcription and translation. Loss of PDCD4 expression has been found in several types of human cancers including the most common cancer of the brain, the gliomas. However, the molecular mechanisms resp... | 18,793,349 |
Immunohistochemical localization of Toll-like receptors 1-10 in periodontitis. | In periodontitis, bacteria and pathogen-associated molecular patterns are sensed by Toll-like receptors (TLRs), which initiate intracellular signaling cascades that may lead to host inflammation. In this study, the expression and distribution of TLRs (TLR-1 to TLR-10) were immunohistochemically detected in gingival epi... | 18,793,367 |
Ecology and ethnoecology of dusky grouper [garoupa, Epinephelus marginatus (Lowe, 1834)] along the coast of Brazil. | Dusky grouper (garoupa, Epinephelus marginatus) is an important catch for several artisanal small-scale fisheries along the Brazilian coast. It is a sedentary, monandric, and late maturing protogynous species, which makes it vulnerable to overharvesting even though it is mainly caught through hook and line or spear fis... | 18,793,394 |
Design and methods for a randomized clinical trial treating comorbid obesity and major depressive disorder. | Obesity is often comorbid with depression and individuals with this comorbidity fare worse in behavioral weight loss treatment. Treating depression directly prior to behavioral weight loss treatment might bolster weight loss outcomes in this population, but this has not yet been tested in a randomized clinical trial. T... | 18,793,398 |
Ultrasonographically detected gallbladder polyps: a reason for concern? A seven-year follow-up study. | The management of coincidental detected gallbladder polyps (GP) is still nebulous. There are few published data regarding their long-term growth. Objective of the present study was to investigate the prevalence and growth of gallbladder polyps in a survey of unselected subjects from the general population of a complete... | 18,793,401 |
Should countries implementing an artemisinin-based combination malaria treatment policy also introduce rapid diagnostic tests? | Within the context of increasing antimalarial costs and or decreasing malaria transmission, the importance of limiting antimalarial treatment to only those confirmed as having malaria parasites becomes paramount. This motivates for this assessment of the cost-effectiveness of routine use of rapid diagnostic tests (RDTs... | 18,793,410 |
Serum anticholinergic activity and cerebral cholinergic dysfunction: an EEG study in frail elderly with and without delirium. | Delirium increases morbidity, mortality and healthcare costs especially in the elderly. Serum anticholinergic activity (SAA) is a suggested biomarker for anticholinergic burden and delirium risk, but the association with cerebral cholinergic function remains unclear. To clarify this relationship, we prospectively asses... | 18,793,418 |
Allele distribution and genetic diversity of VNTR loci in Salmonella enterica serotype Enteritidis isolates from different sources. | Salmonella enterica serotype Enteritidis (S. Enteritidis) is a zoonotic pathogen, which can be found in many sources including animals and the environment. However, little is known about the molecular relatedness among S. Enteritidis isolates from different sources. We have applied multiple-locus variable number tandem... | 18,793,420 |
Targeted physiotherapy for patellofemoral joint osteoarthritis: a protocol for a randomised, single-blind controlled trial. | The patellofemoral joint (PFJ) is one compartment of the knee that is frequently affected by osteoarthritis (OA) and is a potent source of OA symptoms. However, there is a dearth of evidence for compartment-specific treatments for PFJ OA. Therefore, this project aims to evaluate whether a physiotherapy treatment, targe... | 18,793,446 |
Social capital, economics, and health: new evidence. | In introducing this Special Issue on Social Capital and Health, this article tracks the popularization of the term and sheds light on the controversy surrounding the term and its definitions. It sets out four mechanisms that link social capital with health: making information available to community members, impacting s... | 18,793,475 |
Social capital and the social formation of health-related preferences and behaviours. | Social capital appears to be an important determinant of health production and health utilization and demand. However, there is limited evidence on the mechanisms underlying this relationship. In this article we draw on the evidence and insights reported in this special issue along with findings from the economic and o... | 18,793,480 |
Effect of dental finishing instruments on the surface roughness of composite resins as elucidated by atomic force microscopy. | Roughness increases significantly after finishing procedures. The aim of this study was to assess by the atomic force microscope (AFM) the effect of finishing instruments on the surface roughness of composite resins. A nanofiller composite resin (Filtek Supreme, 3M-F) and a microhybrid composite resin (Point 4, Kerr-P)... | 18,793,482 |
A new evaluation tool to obtain practice-based evidence of worksite health promotion programs. | The Centers for Disease Control and Prevention developed the Swift Worksite Assessment and Translation (SWAT) evaluation method to identify promising practices in worksite health promotion programs. The new method complements research studies and evaluation studies of evidence-based practices that promote healthy weigh... | 18,793,506 |
Enforcement of state indoor tanning laws in the United States. | Twenty-eight US states have passed legislation for indoor tanning facilities. To our knowledge, whether these state laws are actually enforced has not been evaluated previously in all 28 states. Therefore, we interviewed key informants in these states to assess enforcement practices. Two trained interviewers used a str... | 18,793,513 |
Conversion from sirolimus to everolimus in maintenance renal transplant recipients within a calcineurin inhibitor-free regimen: results of a 6-month pilot study. | To provide data on conversion of kidney transplant patients from sirolimus to everolimus. In this 6-month prospective, open-label pilot study, maintenance renal transplant patients receiving sirolimus, mycophenolic acid and corticosteroids without concomitant calcineurin inhibitor (CNI) therapy were converted to everol... | 18,793,527 |
Is Cystatin C more sensitive than creatinine in detecting early chronic allograft nephropathy? | Cystatin C (CyC) has been suggested as a more accurate indicator of renal function than creatinine (Crea). CyC performance against graft histopathology has not been investigated. To compare CyC and Crea-based methods as predictors of chronic allograft damage index (CADI). 105 protocol biopsies obtained at 6 months post... | 18,793,544 |
Sexual function in women undergoing hemodialytic treatment assessed using the female sexual function index (FSFI) and the somatic inkblot series (SIS) test. | Female sexuality in end-stage renal disease has so far only been explored using non-validated tools. The aim of this study was to compare sexual function among hemodialyzed (HD) patients and healthy controls using validated questionnaires. Two internationally validated tests have been administrated: the female sexual f... | 18,793,548 |
Population pharmacokinetics study of remifentanil in Chinese adult patients determined by an LC-MS/MS method. | The aim of this study was to construct the population pharmacokinetic model in Chinese adult patients and to characterize the factors that affect the parameters of remifentanil pharmacokinetics. 15 patients were divided randomly into two groups: Index (modeling) group and validation group. 10 patients including 99 bloo... | 18,793,578 |
Utility of the Roussel Uclaf Causality Assessment Method (RUCAM) to analyze the hepatic findings in a clinical trial program: evaluation of the direct thrombin inhibitor ximelagatran. | Causality assessment in drug-induced liver injury is often based on circumstantial evidence rather than a formal, systematic review. The Roussel Uclaf Causality Assessment Method (RUCAM) provides a more objective means of assessing causality of a suspected hepatotoxin but, to our knowledge, has never been used in the a... | 18,793,587 |
Periodontal conditions in Williams Beuren syndrome: a series of 8 cases. | Williams Beuren syndrome (WBS) is an unusual hereditary connective tissue disease caused by a microdeletion at position 7q11-23 and a haploinsufficiency at the elastin gene. The most frequent specific features are elf-like face, alteration of cognitive functions and cardiovascular diseases including isolated supravalvu... | 18,793,597 |
Case report: scurvy in an epileptic child on a ketogenic diet with oral complications. | Epilepsy is a symptom of cerebral dysfunction, where there is a sudden and disorganised discharge of electrical activity from a group of neurones, producing symptoms that range from sensory absences to convulsive movements and unconsciousness. Fasting is recognised as reducing the frequency of epileptic seizures in dif... | 18,793,598 |
A high-throughput assay based on fluorescence polarization for inhibitors of the polo-box domain of polo-like kinase 1. | The serine/threonine kinase polo-like kinase 1 (Plk1) is critically involved in multiple mitotic processes and has been established as an adverse prognostic marker for tumor patients. Plk1 localizes to its substrates and its intracellular anchoring sites via its polo-box domain (PBD), which is unique to the family of p... | 18,793,607 |
Serum nitric oxide metabolites in subjects with metabolic syndrome. | Evidence are available showing that higher nitric oxide production is associated with metabolic disorders. The aim of this study was to determine serum nitric oxide metabolites (NOx) concentration in subjects with metabolic syndrome (MetS). In a cross-sectional study, NOx was measured in 3505 subjects, aged 20-94 years... | 18,793,628 |
LAU-0901, a novel platelet-activating factor antagonist, is highly neuroprotective in cerebral ischemia. | Platelet-activating factor (PAF) is a bioactive phospholipid that accumulates during ischemia-reperfusion and is involved in the activation of platelets, neutrophils, and pro-inflammatory signaling. PAF has been suggested to enhance brain ischemia-reperfusion damage. LAU-0901, a novel PAF receptor antagonist, was exami... | 18,793,637 |
Cysteine peptidases in the tomato trypanosomatid Phytomonas serpens: influence of growth conditions, similarities with cruzipain and secretion to the extracellular environment. | We have characterized the cysteine peptidase production by Phytomonas serpens, a tomato trypanosomatid. The parasites were cultivated in four distinct media, since growth conditions could modulate the synthesis of bioactive molecules. The proteolytic profile has not changed qualitatively regardless the media, showing t... | 18,793,639 |
Thermodynamics, kinetics, and salt dependence of folding of YopM, a large leucine-rich repeat protein. | Small globular proteins have many contacts between residues that are distant in primary sequence. These contacts create a complex network between sequence-distant segments of secondary structure, which may be expected to promote the cooperative folding of globular proteins. Although repeat proteins, which are composed ... | 18,793,647 |
Aspects of the progesterone response in Hortaea werneckii: Steroid detoxification, protein induction and remodelling of the cell wall. | Progesterone in sublethal concentrations temporarily inhibits growth of Hortaea werneckii. This study investigates some of the compensatory mechanisms which are activated in the presence of progesterone and are most probably contributing to escape from growth inhibition. These mechanisms lead on the one hand to progest... | 18,793,662 |
Proprioceptive sensibility in the elderly: degeneration, functional consequences and plastic-adaptive processes. | As the percentage of individuals over the age of 60 years continues to rise, determining the extent and functional significance of age-related declines in sensorimotor performance is of increasing importance. This review examines the specific contribution of proprioceptive feedback to sensorimotor performance in older ... | 18,793,668 |
Synthesis and characterization of PEG-PCL-PEG thermosensitive hydrogel. | In this work, a series of biodegradable triblock poly(ethylene glycol)-poly(epsilon-caprolactone)-poly(ethylene glycol) (PEG-PCL-PEG, PECE) copolymers were successfully synthesized by ring-opening copolymerization, and were characterized by (1)H NMR, FT-IR, GPC, and DSC. Aqueous solutions of PECE copolymers underwent t... | 18,793,709 |
Immunological and pathological changes in the placenta during infection with Listeria monocytogenes in pregnant guinea pigs. | Exposure to Listeria monocytogenes during pregnancy can result in spontaneous abortion and stillbirths; however, the mechanisms are unknown. Our objective was to determine the effects of infection on specific inflammatory and anti-inflammatory cytokine mRNA expression and apoptosis in the placenta after infection with ... | 18,793,713 |
Recombinant expression, purification, and characterization of XorKII: a restriction endonuclease from Xanthomonas oryzae pv. oryzae. | An endonuclease from Xanthomonas oryzae pathovar oryzae (Xoo) KACC10331, XorKII, was recombinantly produced in Escherichia coli by applying the stationary state induction method, which was necessary to prevent the unwanted lysis of E. coli cells. XorKII was purified by immobilized metal affinity chromatography on an FP... | 18,793,728 |
Evidence for abnormalities of cortical development in adolescent-onset schizophrenia. | Voxel-Based Morphometry (VBM) identifies differences in grey matter brain structure in patients with schizophrenia relative to healthy controls, with particularly prominent differences found in patients with the more severe, adolescent-onset form of the disease. However, as VBM is sensitive to a combination of changes ... | 18,793,730 |
Large-scale brain networks account for sustained and transient activity during target detection. | Target detection paradigms have been widely applied in the study of human cognitive functions, particularly those associated with arousal, attention, stimulus processing and memory. In EEG recordings, the detection of task-relevant stimuli elicits the P300 component, a transient response with latency around 300 ms. The... | 18,793,734 |
Natural-cycle in vitro fertilization in poor responder patients: a survey of 500 consecutive cycles. | To determine the role of the natural cycle for in vitro fertilization (IVF) in poor responder patients. Retrospective survey. Private center for assisted reproduction. 294 women who were poor responders in a previous IVF cycle. Analysis of 500 consecutive natural cycles IVF. Number of cycles with oocytes, pregnancy rat... | 18,793,777 |
Induction of the cytokine TWEAK and its receptor Fn14 in ischemic stroke. | Stroke outcome is determined by delayed neuronal cell death and edema formation. TWEAK, a cytokine of the TNF superfamily, and its membrane receptor Fn14 promote ischemia-induced neuronal apoptosis and leakage of the blood-brain barrier. Both TWEAK and Fn14 are upregulated in experimental stroke models. In this study, ... | 18,793,781 |
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