title stringlengths 0 1.13k | abstract stringlengths 1 15.7k | PMID int64 22 36.5M |
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Role of DNA double-strand break repair genes in cell proliferation under low dose-rate irradiation conditions. | Radiation-induced DNA double-stand breaks (DSBs) lead to numerous biological effects. To elucidate the molecular mechanisms involved in cellular responses to low dose and low dose-rate radiation, it is informative to clarify the roles of DSB repair related genes. In higher vertebrate cells, there are at least two major... | 18,797,158 |
Cows milk-dependent exercise-induced anaphylaxis under the condition of a premenstrual or ovulatory phase following skin sensitization. | A 24 year-old woman with atopic dermatitis occasionally developed symptoms, including dyspnea and generalized urticaria, following ingestion of food containing cows milk. Similar episodes had continued, and had been treated empirically since the age of 16 years. Although a skin test and IgE RAST showed positive reactio... | 18,797,181 |
Correlation between the prostaglandin D(2)/E(2) ratio in nasal polyps and the recalcitrant pathophysiology of chronic rhinosinusitis associated with bronchial asthma. | The prevalence of patients with chronic rhinosinusitis (CRS) refractory to traditional therapy appears to be on the increase. In these cases, CRS tends to be associated with bronchial asthma (BA), especially, aspirin-intolerant asthma (AIA). On the other hand, arachidonic acid metabolites have been extensively investig... | 18,797,183 |
Risk factors for death in children and adolescents with cancer and sepsis/septic shock. | To assess risk factors for mortality in children and adolescents with cancer and sepsis/septic shock, admitted to intensive care unit. Retrospective study of a cohort of cancer and sepsis/septic shock patients (n=155) admitted to Oncological Pediatric Intensive Care Unit, between October 1998 and October 2001, with ass... | 18,797,197 |
Metastatic hepatic epithelioid hemangioendothelioma in a teenage girl. | Hepatic epithelioid hemangioendothelioma (HEHE) is a rare malignant tumor characterized by its epithelioid structure and vascular endothelium origin. The clinical course of HEHE is variable, ranging from long-term survival without treatment to a rapidly progressive course with a fatal outcome. As a consequence, no stan... | 18,797,205 |
Asymmetrical visual-spatial attention in college students diagnosed with ADD/ADHD. | Research indicates that individuals with attention deficit disorder (ADD)/attention deficit hyperactivity disorder (ADHD) may exhibit left-right asymmetric spatial attention, with deficient processing of stimuli in the left visual hemispace. However, there is controversy as to when this phenomenon can be observed. Peop... | 18,797,260 |
Human papillomavirus vaccine and adolescents. | The present review describes recent advances in our understanding about the epidemiology of human papillomavirus infection among female adolescents and describes several adolescent-specific issues related to administering human papillomavirus vaccines. National estimates demonstrate that human papillomavirus infection ... | 18,797,267 |
Intrauterine devices and adolescents. | The purpose of this review is to inform the reader of new information published on intrauterine devices (IUDs) and adolescents. There are few studies on the use of IUDs in adolescents. The article reviews topics related to IUD use such as adolescents' knowledge of and attitudes toward IUDs, mechanism of action of coppe... | 18,797,269 |
The use of grafts for anterior vaginal prolapse repair: pros and cons. | To review the advantages and disadvantages of ungrafted and grafted methods of anterior vaginal prolapse repair. Successful correction of anterior vaginal prolapse remains one of the most challenging aspects of pelvic reconstructive surgery. Anterior colporrhaphy is associated with an unacceptably high recurrence rate.... | 18,797,276 |
Migraine-associated vestibulopathy. | In the past few years, otologists have been seeing an increasing number of patients with vestibular disorders due to migraine-associated vestibulopathy. This article reviews some of the latest developments in the understanding of this disease process, specifically its incidence, symptoms, diagnosis, and treatment. Migr... | 18,797,281 |
Gap junctions and connexins in the inner ear: their roles in homeostasis and deafness. | Mutations in GJB2 and GJB6, the genes encoding the gap-junction proteins connexin 26 and connexin 30, are the most common cause of autosomal recessive nonsyndromic deafness in many populations across the world. In this review, we discuss current ideas about the roles of gap junctions in the inner ear and the implicatio... | 18,797,288 |
Neuroanatomy of verbal working memory as a diagnostic biomarker for depression. | The functional neuroanatomy of verbal working memory is a potential diagnostic biomarker for depression. Twenty patients with unipolar depression and 20 healthy controls performed a variable load version (n-back) of the task. Functional MRI data were analysed with support vector machine methods. Diagnostic classificati... | 18,797,307 |
Cerebellar deficits in schizophrenia are associated with executive dysfunction. | Cerebellar abnormalities have been documented in schizophrenia in postmortem, functional and volumetric neuroimaging studies. This study aims to establish the relationship between structural changes in the cerebellum and executive dysfunction in patients with schizophrenia using voxel-based morphometry. We compared 28 ... | 18,797,308 |
Projections of olfactory bulbs to the olfactory and vomeronasal cortices. | Projections from the olfactory bulbs have been traditionally described as 'nontopographically organized'. Olfactory and vomeronasal projections have been reported to reach nonoverlapping cortical areas. Four receptor expression zones have been described in the olfactory epithelium, maintained in the main olfactory bulb... | 18,797,313 |
Morphology parameters for intracranial aneurysm rupture risk assessment. | The aim of this study is to identify image-based morphological parameters that correlate with human intracranial aneurysm (IA) rupture. For 45 patients with terminal or sidewall saccular IAs (25 unruptured, 20 ruptured), three-dimensional geometries were evaluated for a range of morphological parameters. In addition to... | 18,797,347 |
Outcomes after repeat transsphenoidal surgery for recurrent Cushing's disease. | To systematically analyze patient outcomes after repeat transsphenoidal (TS) surgery for recurrent Cushing's disease. We retrospectively reviewed records of all patients with recurrent Cushing's disease who underwent repeat TS surgery for resection of a pituitary corticotroph adenoma at the University of Virginia Medic... | 18,797,356 |
Ecstasy (3,4-methylenedioxymethamphetamine)-induced inappropriate antidiuretic hormone secretion. | 3,4-Methylenedioxymethamphetamine (MDMA), popularly known as the illicit drug "Ecstasy," is an amphetamine derivative that has become widely abused throughout the United States and other industrialized nations. 3,4-Methylenedioxymethamphetamine has an undeserved reputation as a "safe" drug among its users, but MDMA sha... | 18,797,371 |
Faster than a speeding bullet: changes in medicare rules for the hospital case manager. | Compliance with the various Centers for Medicare & Medicaid Services rules and regulations is rapidly becoming a challenge in hospitals as the frequency and complexity of the new mandates have increased. Although compliance officers may oversee major elements emanating from the regulatory agencies, practical applic... | 18,797,384 |
Fibrogenic polymorphisms (TGF-beta, PAI-1, AT) in Mexican patients with established liver fibrosis. Potential correlation with pirfenidone treatment. | The aim of this work was to establish a potential correlation between specific polymorphisms and presence of hepatic fibrosis in Mexican patients with established liver fibrosis (ELF). Second, necroinflammatory index improvement was correlated with Pirfenidone (PFD) treatment response and the same polymorphisms. We ana... | 18,797,412 |
Longitudinal study of self-reported sexually transmitted infection incidence by gender and age up to age thirty-two years. | To examine how incidence of self-reported sexually transmitted infections (STIs) varies by gender and age, and the factors that influence this. A longitudinal study of a cohort born in Dunedin, New Zealand in 1972/1973. They were questioned about STIs and sexual behavior at age 21, 26, and 32 years (1993-2005). Inciden... | 18,797,425 |
Ethnic differences in cardiovascular disease risk factors and diabetes status for Pacific ethnic groups and Europeans in the Diabetes Heart and Health Survey (DHAH) 2002-2003, Auckland New Zealand. | The aim of this paper is to provide levels of cardiovascular disease (CVD) risk factors and diabetes status for Pacific ethnic groups and make comparisons amongst these groups (Samoan, Tongan, Niuean, Cook Islanders) with European New Zealanders by gender from the 2002-03 DHAH Survey. The DHAH was a cross-sectional pop... | 18,797,481 |
Ethnic counts on mortality and census data (mostly) agree for 2001-2004: New Zealand Census-Mortality Study update. | The New Zealand Census-Mortality Study (NZCMS) previously demonstrated substantial undercounting of Maori and Pacific deaths on mortality data relative to census data for the 1980s and 1990s. The recent linkage of 2001-04 mortality data to 2001 census data allows us to determine whether any such 'numerator-denominator'... | 18,797,482 |
Neural correlates of perceiving emotional faces and bodies in developmental prosopagnosia: an event-related fMRI-study. | Many people experience transient difficulties in recognizing faces but only a small number of them cannot recognize their family members when meeting them unexpectedly. Such face blindness is associated with serious problems in everyday life. A better understanding of the neuro-functional basis of impaired face recogni... | 18,797,499 |
Unveiling the bmp13 enigma: redundant morphogen or crucial regulator? | Bone morphogenetic proteins are a diverse group of morphogens with influences not only on bone tissue, as the nomenclature suggests, but on multiple tissues in the body and often at crucial and influential periods in development. The purpose of this review is to identify and discuss current knowledge of one vertebrate ... | 18,797,508 |
The role of general practice in cancer care. | The incidence of cancer is rising, so the workload of managing cancer is increasing rapidly. Among the advances in cancer care are advances in coordination of care, with team care being a preferred method. This article examines the role of the general practitioner, by looking at each step in the patient's cancer journe... | 18,797,526 |
[Prevalence and co-occurrence of five types of ill-treatment in relation with depression and conduct disorder in adolescent mothers]. | In this article, the authors reflect on co-occurrence of different types of maltreatment that adolescent mothers have suffered during their childhood in order to better understand intergenerational transmission of maltreatment. They underline that studies on maltreatment that adults or adolescents have been subjected t... | 18,797,540 |
[The influence of estrogen and progestogen replacement on growth hormone activity in women with hypopituitarism]. | Treatment of hypogonadotropic hypogonadism in adult women with hypopituitarism can include a wide range of estrogen and progestogen treatment alternatives and oral administration is the route of least cost and greatest patient comfort. The oral estrogen route has a major impact on the growth hormone-insulin-like growth... | 18,797,598 |
Ethical analysis to improve decision-making on health technologies. | Health technology assessment (HTA) is the multidisciplinary study of the implications of the development, diffusion and use of health technologies. It supports health-policy decisions by providing a joint knowledge base for decision-makers. To increase its policy relevance, HTA tries to extend beyond effectiveness and ... | 18,797,620 |
Methods of suicide: international suicide patterns derived from the WHO mortality database. | Accurate information about preferred suicide methods is important for devising strategies and programmes for suicide prevention. Our knowledge of the methods used and their variation across countries and world regions is still limited. The aim of this study was to provide the first comprehensive overview of internation... | 18,797,649 |
Age norms for monocular grating acuity measured by sweep-VEP in the first three years of age. | To determine age norms for grating visual acuity and interocular acuity differences measured by the sweep-visually evoked potentials (VEP) technique in the first three years of life. Monocular grating visual acuity was measured using the sweep-VEP in 67 healthy normal infants and children in the first 36 months of life... | 18,797,653 |
[Results and complications of bicanalicular intubation in external dacryocystorhinostomy]. | To analyze the success rate and complications in patients with lacrimal obstruction submitted to surgeries. The data of patients operated in the "Hospital do Servidor Público Estadual of São Paulo" were analyzed. The lacrimal intubation was performed with a silicone tube, removed after 8 weeks. Surgeries were considere... | 18,797,663 |
[Association between optic disc hemorrhages and the position of central retinal vessels]. | To investigate the correlation between optic disc hemorrhages (ODHs) and the position of the central retinal vessel trunk (RVT) in patients with glaucoma. Fundus photographs of 1,830 participants were reviewed. The exit position of the central retinal vessel trunk was classified as being in the superior or inferior hem... | 18,797,668 |
Perineural arachnoidal gliomatosis: case report. | Gliomas are the most common infiltrative neoplasms of the optic nerve and can present as two distinct growth patterns: intraneural glial proliferation and perineural arachnoidal gliomatosis (PAG). It has been suggested that perineural arachnoidal gliomatosis is seen almost exclusively in the setting of neurofibromatosi... | 18,797,677 |
The effect of gastric dilatation in rats submitted to gasified water ingestion under the hepatic metabolic function. | The amounts of people that are overweight have been increasing within the population in significant ways during the last decades. In this view, gasified beverages have become an important environmental concern in relation to the eating habits of people, especially who lives in the USA, Mexico, and Brazil. In this order... | 18,797,684 |
Rosuvastatin and vascular dysfunction markers in pulmonary arterial hypertension: a placebo-controlled study. | We investigated whether chronic rosuvastatin administration could improve the abnormalities of the circulating levels of vascular dysfunction markers in pulmonary arterial hypertension (PAH). Sixty patients, aged 13 to 60 years, with idiopathic (N = 14) or congenital heart disease-associated PAH (N = 46) were equally b... | 18,797,697 |
N-terminal prohormone brain natriuretic peptide (NT-proBNP) as a noninvasive marker for restrictive syndromes. | Constrictive pericarditis (CP) and restrictive cardiomyopathy share many similarities in both their clinical and hemodynamic characteristics and N-terminal prohormone brain natriuretic peptide (NT-proBNP) is a sensitive marker of cardiac diastolic dysfunction. The objectives of the present study were to determine wheth... | 18,797,698 |
Vascular complications of black patients with type 2 diabetes mellitus in Southern Brazil. | Ethnicity has been shown to be associated with micro- and macrovascular complications of diabetes in European and North American populations. We analyzed the contribution of ethnicity to the prevalence of micro- and macrovascular complications in Brazilian subjects with type 2 diabetes attending the national public hea... | 18,797,699 |
Breastfeeding and feeding patterns in three birth cohorts in Southern Brazil: trends and differentials. | Breastfeeding is fundamental for child health. Changes in the duration of breastfeeding are compared for three population-based cohorts of children born in 1982, 1993 and 2004 in the city of Pelotas, Southern Brazil. Samples of the 1982 and 1993 children and all of the children from the 2004 cohort study were sought at... | 18,797,716 |
Infant mortality in three population-based cohorts in Southern Brazil: trends and differentials. | We studied time trends in infant mortality and associated factors between three cohort studies carried out in Pelotas, Rio Grande do Sul State, Brazil, in 1982, 1993, and 2004. All hospital births and deaths were determined by means of regular visits to hospitals, registrar's offices, and cemeteries. This data was used... | 18,797,721 |
PAH biomarkers for human health risk assessment: a review of the state-of-the-art. | Polycyclic aromatic hydrocarbons (PAH) are widely distributed in the environment, and some are carcinogenic to human beings. The study of biomarkers has helped clarify the nature and magnitude of the human health risks posed by such substances. This article provides a review of the state-of-the-art on PAH biomarkers fo... | 18,797,723 |
A salutogenic approach to oral health promotion. | Theoretical frameworks on health promotion focusing on social determinants of oral health have highlighted promising approaches for improving the oral health of populations and reducing inequities in oral health. In the last two decades the salutogenic theory has gained ground in the field of health promotion, but not ... | 18,797,728 |
Physical activity during pregnancy and maternal-child health outcomes: a systematic literature review. | A systematic literature review was conducted to investigate the effects of physical activity during pregnancy on selected maternal-child health outcomes. The search included articles published from 1980 to 2005 in the MEDLINE and LILACS databases using key words such as physical activity, physical exercise, pregnancy, ... | 18,797,729 |
Antimicrobial resistance among Brazilian Corynebacterium diphtheriae strains. | The increasing problems with multidrug resistance in relation to Corynebacterium, including C. diphtheriae, are examples of challenges confronting many countries. For this reason, Brazilian C. diphtheriae strains were evaluated by the E-Test for their susceptibility to nine antibacterial drugs used in therapy. Resistan... | 18,797,769 |
[Educational obstacles in the everyday living of the nurse teacher's pedagogical practice]. | University teaching emerges as a theme frequently discussed in the educational scene. This article aims to investigate the educational obstacles emerging in the everyday living of the pedagogical practice of the nurse teacher from the Nursing Graduation Course at UEPSI, wishing to subsidize the elaboration of proposals... | 18,797,777 |
[Sexual violence against children in a family environment attended by SAMVVIS, Teresina, PI]. | This study deals with the characterization of sexual violence in children seen at the Services for the Assistance of Women Victims of Sexual Violence (SAMVVIS) from 2004 to 2007 in Teresina, PI. Data collected from 229 charts indicate that the age of the children varies from less than one year up to 12 years of age. Th... | 18,797,781 |
[Nature, classification and nursing interventions for patients with mediastinitis]. | This is a descriptive and retrospective study that aimed at analyzing the nature and classification of nursing interventions for patients with mediastinitis following cardiac surgery. The results obtained from the surgical wards show an incidence of mediastinitis of 3%. The subjects studies were primarily male, all of ... | 18,797,783 |
Superoxide dismutase and lipid hydroperoxides in blood and endometrial tissue of patients with benign, hyperplastic and malignant endometrium. | Epidemiological and experimental data point to involvement of oxygen derived radicals in the pathogenesis of gynecological disorders, as well as in cancer development. The objective of the present study was to examine changes in activities and levels of copper/zinc superoxide dismutase (CuZnSOD) and lipid hydroperoxide... | 18,797,802 |
Secular trends in hip fracture incidence and recurrence. | The decline in hip fracture incidence is now accompanied by a further reduction in the likelihood of a recurrent hip fracture among survivors of the first fracture. Hip fracture incidence is declining in North America, but trends in hip fracture recurrence have not been described. All hip fracture events among Olmsted ... | 18,797,813 |
Effects of exhaustion and calcium supplementation on adrenocorticotropic hormone and cortisol levels in athletes. | The present study was performed to investigate the effects of strenuous exercise and calcium supplementation on cortisol and adrenocorticotropic hormone levels in athletes at rest and exhaustion. Thirty male athletes, ages 17-21 years, were enrolled in the 4-week study. They were divided into three groups as follows: g... | 18,797,825 |
Analysis of condylar differences in functional unilateral posterior crossbite during early treatment--a randomized clinical study. | The analysis of potential discrepancies in condyle position among different occlusal relations (centric relation and maximum intercuspidation) is a key diagnostic component when treating children with unilateral posterior crossbite. Due to strict requirements imposed by ethics committees, and new regulations regarding ... | 18,797,832 |
A 57-year follow-up study of occlusion. Part 2: oral health and attitudes to teeth among individuals with deep overbite at the age of 8 years. | To analyze changes in occlusion between the ages of 8 and 65 years in persons with a deep overbite at the age of 8 who did not receive orthodontic treatment. To describe their experiences regarding their own dentition as well as their opinions on dental esthetics and oral health. To compare these findings with those of... | 18,797,834 |
Phenotypic and genetic characterization of the pistillate mutation in tomato. | Many floral phenotypes have been described in decades of tomato genetics, but for very few of them the underlying genes have been identified so far. Because the increasing availability of genome sequence data will facilitate forward genetics in tomato, novel descriptive and map information will help the attribution of ... | 18,797,840 |
Evaluation of a pharmacokinetic hypothesis for reduced locomotor stimulation from methamphetamine and cocaine in adolescent versus adult male C57BL/6J mice. | Adolescent mice display reduced locomotor stimulation to cocaine and amphetamine compared to adults, but the mechanisms are not known. The primary aim of the current study is to test a possible pharmacokinetic explanation for the attenuated locomotor stimulation seen in adolescents. A secondary aim is to extend the cur... | 18,797,848 |
Static-dynamic sequential superheated liquid extraction of phenols and fatty acids from alperujo. | Superheated liquids of different polarity have been used for sequential extraction of fatty acids and phenols from alperujo. Multivariate methodology has been used to optimise the static-dynamic extraction. Forty-two minutes are required to complete extraction (20 mg/kg of fatty acids and up to 2,200 mg/kg of hydroxyty... | 18,797,851 |
Cortical and cerebellar activation induced by reflexive and voluntary saccades. | Reflexive saccades are driven by visual stimulation whereas voluntary saccades require volitional control. Behavioral and lesional studies suggest that there are two separate mechanisms involved in the generation of these two types of saccades. This study investigated differences in cerebral and cerebellar activation b... | 18,797,855 |
Ethnic differences in immunogenetic features and photosensitivity of cutaneous lupus erythematosus. | Genetic differences are involved in the development of lupus erythematosus (LE). Skin lesions are influenced by environmental triggers such as ultraviolet light, temperature, and chemical stresses, and the patterns of skin lesion are variable in cutaneous LE such as systemic LE (SLE), chronic discoid LE (CDLE), subacut... | 18,797,890 |
Two methods for determining plasma IL-6 in humans at rest and following exercise. | We compared two methods to determine IL-6 at rest and following exercise. On two occasions, plasma IL-6 was determined in 10 men and 13 women before and immediately following 90 min of cycling at 65% V(O)(2max) using a cytometric bead array (CBA) and an ELISA. The CBA detected IL-6 in 63% of pre-exercise samples and 84... | 18,797,920 |
Sponge OAS has a distinct genomic structure within the 2-5A synthetase family. | 2',5'-Oligoadenylate synthetases (2-5A synthetases, OAS) are enzymes that play an important role in the interferon-induced antiviral defense mechanisms in mammals. Sponges, the evolutionarily lowest multicellular animals, also possess OAS; however, their function is presently unclear. Low homology between primary struc... | 18,797,928 |
Course of distress in breast cancer patients, their partners, and matched control couples. | Previous studies offer a limited perspective on the dynamic course of distress in cancer patients and their partners, owing to a restricted number of assessment points and the absence of comparison controls drawn from the general population. This study investigated the course of distress among breast cancer patients an... | 18,797,979 |
Gallstone ileus: a difficult emergency diagnosis! | Gallstone ileus (GSI) is a rare cause of mechanical small bowel obstruction. It occurs when a fistula between the gallbladder and the small bowel facilitates the migration of gallstone(s) into the small bowel. The commonest site of impaction is in the terminal ileum. We report the case of a 71-year-old female presentin... | 18,797,981 |
Protective potential of SCF for mice preimplantation embryos cultured in vitro in suboptimal conditions. | To examine the effect of stem cell factor (SCF) to embryos exposed to detrimental factors. Mice embryos cultured in control medium or Exp.1. with FasL or FasL+SCF Exp.2. with hydrogen peroxide (HP) or HP+SCF; Exp.3. frozen-thawed and cultured with or without SCF. Immunohistochemistry for Fas and c-kit receptors was per... | 18,797,989 |
Colonic carcinoma presenting as strangulated inguinal hernia: report of two cases and review of the literature. | Inguinal hernia and colonic carcinoma are common surgical conditions, yet carcinoma of the colon occurring within an inguinal hernia sac is rare. Of 25 reported cases, only one was a perforated sigmoid colon carcinoma in an inguinal hernia. We report two cases of sigmoid colon carcinoma, one of which had locally perfor... | 18,798,013 |
Modelling Aspergillus fumigatus infections in racing pigeons (Columba livia domestica). | In vivo modelling of aspergillosis in birds allows the evaluation of control measures and the study of host-pathogen interactions. In this study the impact of the use of different inoculation routes and immunosuppression on the course of an infection with Aspergillus fumigatus in racing pigeons (Columba livia domestica... | 18,798,031 |
Use of computerized models to reduce the consequences of major outbreaks of food-borne illness. | Food-borne outbreak modelling is a technique by which statistical methodologies and data are used to model various aspects of food contamination outbreaks, with the primary goal of helping to reduce the threat of food-borne illness. There are two primary approaches to such modelling: risk ranking and pathway analysis. ... | 18,798,035 |
Measurement of nitric oxide in the vagina. | Local measurement of nitric oxide (NO) gas has been used to detect and monitor inflammatory processes in the airways, the colon and in the urinary bladder, but so far NO has not been studied in the lower female genital tract. The objective of this study is to measure NO gas directly in the vaginal lumen of healthy wome... | 18,798,053 |
Over-expression of COX-2 induces human ovarian cancer cells (CAOV-3) viability, migration and proliferation in association with PI3-k/Akt activation. | COX-2 is involved in several pathological processes. The action of COX-2 on human ovarian cancer cell line (CAOV-3) and relative signal pathway has not been demonstrated. We explored the effects of COX-2 on the CAOV-3 viability and migration, moreover the proliferation of CAOV-3, and then ascertained the roles of PI3-k... | 18,798,061 |
Overexpression of high mobility group (HMG) B1 and B2 proteins directly correlates with the progression of squamous cell carcinoma in skin. | High mobility group B (HMGB) chromosomal proteins, which plays important role in cancer and inflammation, were followed at various stages of the squamous cell carcinoma of skin. Present results were analyzed by histopathology, BrdU assay, immunohistochemistry, western blot and RT-PCR, which indicate that at early stage... | 18,798,064 |
Retinal function in X-linked ocular albinism (OA1). | To characterize retinal function in human recessive X-linked ocular albinism (OA1) across the normal lifespan. Retinal function was evaluated in 14 OA1 patients (ages 11 to 71 years) and five obligate carriers (ages 41 to 50 years) and compared to normal controls using full-field and multi-focal electroretinograms (ERG... | 18,798,082 |
Multiparticulate drug delivery system of aceclofenac: development and in vitro studies. | The aim of this study was to develop an enteric-coated multiunit dosage form containing aceclofenac, a nonsteroidal anti-inflammatory drug. The pellets were prepared by using extrusion/spheronization method, and the core pellets were coated with a pH-sensitive poly(meth) acrylate copolymer (Eudragit L100-55) to achieve... | 18,798,090 |
Biologic features of Hodgkin lymphoma and the development of biologic prognostic factors in Hodgkin lymphoma: tumor and microenvironment. | Classical Hodgkin lymphoma is now recognised as a B-cell lymphoma. Improved therapy has increased cure rates dramatically; however, relapse and death still occurs in a minority of patients. Much has been learned about the biology of Hodgkin and Reed Sternberg cells and their interactions with the microenvironment, whic... | 18,798,102 |
Positron emission tomography in mantle cell lymphoma. | Mantle cell lymphoma (MCL) is a rare but aggressive non-Hodgkin lymphoma subtype with a poor prognosis; most patients relapse despite initial response to therapy. Response was traditionally evaluated by computed tomography (CT), but the introduction of [(18)F]Fluorine-Deoxyglucose Positron Emission Tomography (PET) cha... | 18,798,104 |
Long-term outcome of allogeneic stem cell transplantation in chronic lymphocytic leukemia: analysis after a minimum follow-up of 5 years. | In order to evaluate the long-term results of allogeneic stem cell transplantation (ASCT) in B-cell chronic lymphocytic leukemia (CLL), we reviewed the outcome of 12 consecutive CLL patients, who underwent ASCT at the Mayo Clinic prior to July, 2004. Median age was 44 years (range 18-55) and median time from diagnosis ... | 18,798,106 |
Hepatobiliary disposition of rhodamine 123 in isolated perfused rat livers. | The disposition of rhodamine 123 (RH-123), a known marker of P-glycoprotein, and its liver-generated glucuronide metabolite (RH-Glu), a marker of Mrp2, was studied in an isolated perfused rat liver model. Livers were perfused with a buffer containing 0.1 microg ml(-1) RH-123 for 30 or 60 min or for 30 min followed by 9... | 18,798,123 |
Increased transendothelial permeability of anti-cancer agent carboplatin with the aid of hyperbaric oxygenation. | 1. The objective was to investigate the transport of an anticancer agent carboplatin across the blood-brain barrier in combination with hyperbaric oxygenation treatment. An in vitro well-validated model of bovine brain capillary endothelial cells was used. 2. A transendothelial transport of doxorubicin, a known P-glyco... | 18,798,124 |
Use of partially porous column as second dimension in comprehensive two-dimensional system for analysis of polyphenolic antioxidants. | In the present work, a comprehensive LC system using a microbore HPLC column in the first dimension and a partially porous column in the second dimension was developed and applied to the separation of polyphenolic components in a red wine sample. The performance of the partially porous short column (3.0 cm) was compare... | 18,798,217 |
Breast cancer special types: why bother? | Breast cancer is a heterogeneous disease, encompassing multiple entities associated with distinct biological features and clinical behaviours. Microarray-based expression profiling analysis has been used to unravel the molecular underpinning of several characteristics of breast cancer, including its proclivity to disse... | 18,798,222 |
Low gradient aortic stenosis: assessment, treatment, and outcome. | Aortic stenosis is a commonly encountered valvular disorder in the treatment of cardiovascular disease. Generally, symptomatic patients who undergo valve replacement experience a vast reduction in symptoms and a great improvement in survival. A subset of symptomatic patients in whom management is less clear are those w... | 18,798,234 |
Transcatheter closure of patent ductus arteriosus and aorto-pulmonary vessels using non-ferromagnetic Inconel MReye embolization coils. | We report the use of non-ferromagnetic embolization coils for transcatheter PDA closure. Transcatheter patent ductus arteriosus (PDA) closure has been performed for 40 years. A number of devices have been used with varying degrees of success. Gianturco embolization coils have been used frequently since 1992 with excell... | 18,798,238 |
Biophysical and biochemical characterization of a liposarcoma-derived recombinant MnSOD protein acting as an anticancer agent. | A recombinant MnSOD (rMnSOD) synthesized by specific cDNA clones derived from a liposarcoma cell line was shown to have the same sequence as the wild-type MnSOD expressed in the human myeloid leukaemia cell line U937, except for the presence of the leader peptide at the N-terminus. These results were fully confirmed by... | 18,798,256 |
Probability of parenthood after early onset cancer: a population-based study. | We evaluated in a population-based setting the postdiagnosis parenthood among survivors compared with the fertility patterns of siblings. Cancer patients aged 0-34 years at diagnosis were identified from the Finnish Cancer Registry (N = 25,784), and their siblings (N = 44,611) by registry linkage. Further linkage ident... | 18,798,259 |
Anti-adult T-cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol. | Adult T-cell leukemia (ATL) is a fatal malignancy of T lymphocytes caused by human T-cell leukemia virus type 1 (HTLV-1) infection and remains incurable. Carotenoids are a family of natural pigments and have several biological functions. Among carotenoids, fucoxanthin is known to have antitumorigenic activity, but the ... | 18,798,263 |
Tumor microenvironment: Modulation by decorin and related molecules harboring leucine-rich tandem motifs. | Decorin, the prototype member of the small leucine-rich proteoglycans, resides in the tumor microenvironment and affects the biology of various types of cancer by downregulating the activity of several receptors involved in cell growth and survival. Decorin binds to and modulates the signaling of the epidermal growth f... | 18,798,267 |
Disruption of the blood-brain barrier following ALA-mediated photodynamic therapy. | Photodynamic therapy (PDT) is a local antineoplastic treatment with the potential for tumor cell specificity. PDT using either hematoporphyrin derivatives or 5-aminolevulinic acid (ALA) has been reported to induce brain edema indicating disruption of the blood-brain barrier (BBB). We have evaluated the ability of ALA-m... | 18,798,293 |
Comparison of ultrasound-guided core-needle biopsy and fine-needle aspiration in the assessment of head and neck lesions. | Core-needle biopsy (CNB) has been successfully applied in other medical specialties, but its value is undetermined in otolaryngology. This prospective study includes 75 patients, who were seen at our institution with a cervical mass. The results of CNB were compared with those of fine-needle aspiration (FNA) in the 68 ... | 18,798,314 |
Validation and assessment of voice-related quality of life in Indian patients undergoing total laryngectomy and primary tracheoesophageal puncture. | Voice-related quality of life (V-RQOL) has never been studied in Indian patients. This study was planned to validate and assess V-RQOL in patients using tracheoesophageal puncture (TEP). A cross-sectional study was undertaken to validate V-RQOL questionnaire by testing reliability, validity, and responsiveness. V-RQOL ... | 18,798,315 |
Mutation analysis of B3GALTL in Peters Plus syndrome. | Peters Plus syndrome comprises ocular anterior segment dysgenesis (most commonly Peters anomaly), short stature, hand anomalies, distinctive facial features, and often other additional defects and is inherited in an autosomal-recessive pattern. Mutations in the beta1,3-glucosyltransferase gene (B3GALTL) were recently r... | 18,798,333 |
[Monitoring of patients with breast cancer after multimodal treatment]. | Breast cancer is a frequent neoplasm in Latin America. Its control implies surveillance for about 10 years after diagnosis. The possibilities of metastatic disease depend on stage at diagnosis and the treatment administered to the patient. It is important that all medical centers implement their own follow-up that fits... | 18,798,403 |
[Evidence-based medicine: benefits, inconveniences and risks of a new dogma]. | Progress in biostatistics and epidemiology during twentieth century contributed to clinical research development. Controversy about the real role of these disciplines in validating clinical activity isn't new: in history of medicine there are evidence since nineteenth century. Evidence-based medicine is a recent method... | 18,798,412 |
[Anemic syndrome frequency in complicated obstetrical patients]. | The prevalence of anemia varies from country to country and there is not a trustworthy record. To determine the frequency of anemia in obstetric patients and the association among healthy pregnancy and aggregate complications. Was carried out as transversal, observational and comparative study. Obstetrical patients ent... | 18,798,460 |
[Surgical treatment of temporal lobe epilepsy]. | The surgical treatment of epilepsy is a therapeutic procedure aimed at removal of the brain tissue responsible for seizures. Neurological examinations are performed to delineate the epileptic zone, which is then removed, without causing a functional deficit. In order to fulfill these goals, it is essential to localize ... | 18,798,470 |
[Construction and expression of replication-deficient recombinant adenovirus vector with hNET gene by adeasy-1 system]. | To construct and identify the recombinant replication deficient adenovirus vector which codes for human Norepinephrine Transporter (hNET) gene by using the method of homogenous recombination in bacteria. hNET gene was obtained from the recombinant plasmid pCMV5 via Kpn I + Xba I digestion, and subcloned into E1 deleted... | 18,798,484 |
[Research on construction and expression of recombinant eukaryotic expression plasmid for mouse adiponectin]. | To construct the recombinant eukaryotic expression plasmid for mouse adiponectin so as to supply experimental basis for research further on the function of adiponectin. Extracting the total RNA from mouse adipose tissue, applying RT-PCR to amplify the complete coding region of mouse adiponectin cDNA and connecting the ... | 18,798,486 |
[Protective effect of capsaicin on against myocardial ischemia-reperfusion injury of rat in vivo]. | To explore whether the capsaicin offers protective effect and possible mechanism on against myocardial ischemia-reperfusion injury of rat in vivo. Ligating the left anterior descending coronary artery for 45 min and loosing it for 120 min were performed to establish the rat model of local myocardial ischemia-reperfusio... | 18,798,491 |
[The research of animal model setting-up in human intra-utero fetal cardiac intervention]. | To research the techniques and correlated issues during analogous procedure of human intro-utero fetal cardiac intervention in animal model, so as to impulse the clinical utilizing of cardiac intervention in human fetus with severe cardiovascular malformations. Eight bigeminal pregnant ewes in latter 2nd-trimester and ... | 18,798,514 |
[Determination of trace ammonia in indoor air by ninhydrin spectrophotometry]. | To develop a new spectrophotometric method to detect trace ammonia in indoor air. Ammonia in the air was absorbed by 0.01 mol/L sulfuric acid in a bubbling absorption tube. With 95 degrees C of water bath and pH 5.5-6.0 of buffer solution of acetic acid-sodium acetate, the ammonium in the solution reacted with ninhydri... | 18,798,521 |
The seminal role of Cancer in our understanding of sarcoma. | The journal Cancer has played a critical role in advancing our understanding of sarcoma, a remarkable cluster of malignancies that arise from tissues of mesenchymal origin throughout the human body and indeed across the entire vertebrate animal spectrum. Approximately equally divided between soft tissue and bone origin... | 18,798,535 |
Prenatal and perinatal risk factors for neuroblastoma. | Neuroblastoma is a rare embryonal tumor of childhood for which risk factors are not well known. Using a nested case-control design, we investigated prenatal, perinatal and neonatal risk factors in detail by linking 245 pediatric neuroblastoma cases identified in the Swedish Cancer Register diagnosed in the year 1973-19... | 18,798,548 |
Conservation of notochord gene expression across chordates: insights from the Leprecan gene family. | The notochord is a defining character of the chordates, and the T-box transcription factor Brachyury has been shown to be required for notochord development in all chordates examined. In the ascidian Ciona intestinalis, at least 44 notochord genes have been identified as bona fide transcriptional targets of Brachyury. ... | 18,798,549 |
Accelerated embryonic development associated with increased risk of neural tube defects induced by maternal diet in offspring of SELH/Bc mice. | The SELH/Bc mouse strain has a high risk of the NTD, exencephaly, caused by multifactorial genetics. All SELH/Bc embryos have delayed elevation of neural folds; some never elevate (future exencephalics). Maternal diets affect SELH/Bc exencephaly rates: 25-35% on Purina Diet 5015 versus 5-10% on Purina Diet 5001. We hyp... | 18,798,560 |
Serum antithyroid antibodies in female patients with chronic urticaria. | To determine the frequencies of serum antithyroglobulin and antimicrosomal autoantibodies in female patients with chronic urticaria, and the association between thyroid autoantibodies and chronic urticaria, if any. Non-interventional, case-control analytic study. This study was carried out by the Department of Physiolo... | 18,798,586 |
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